{
  "name": "H2Medicine",
  "language": "en",
  "url": "https://h2medicine.org",
  "other_language_url": "https://h2medizin.org",
  "description": "Scientific evidence overview of molecular hydrogen (H₂) in humans — not medical advice. Null and negative results are included.",
  "license": "Study metadata compiled from public sources (PubMed, CrossRef). Facts, freely reusable with attribution.",
  "endpoints": {
    "meta": "https://h2medicine.org/api/meta.json",
    "catalog": "https://h2medicine.org/api/catalog.json",
    "full": "https://h2medicine.org/api/studies.json",
    "llms": "https://h2medicine.org/llms.txt"
  },
  "total": 731,
  "human": 212,
  "therapeutic": 144,
  "by_evidence_level": {
    "1": 350,
    "2": 148,
    "3": 64,
    "4": 169
  },
  "studies": [
    {
      "pmid": "42050215",
      "year": 2026,
      "title": "The essential role of hydrogen gas recycling by gut microbes in reducing deuterium load in host mitochondria: is trimethylamine oxide a deuterium sensor?",
      "title_en": null,
      "title_de": "Die wesentliche Rolle des Wasserstoffgas-Recyclings durch Darmmikroben bei der Reduzierung der Deuterium-Last in den Mitochondrien des Wirts: Ist Trimethylaminoxid ein Deuterium-Sensor?",
      "journal": "Metabolomics : Official journal of the Metabolomic Society",
      "authors": "Seneff et al.",
      "author_search": "seneff seneff",
      "doi": "10.1007/s11306-026-02443-3",
      "doi_url": "https://doi.org/10.1007/s11306-026-02443-3",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/42050215/",
      "url": "https://h2medicine.org/studies/study-seneff-2026-essential-recycling-gut-microbes/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "diabetes",
        "metabolic",
        "liver",
        "neurology",
        "cardiovascular",
        "cancer",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "41747800",
      "year": 2026,
      "title": "The protective effects of molecular hydrogen in sepsis-associated encephalopathy: current status.",
      "title_en": null,
      "title_de": "Die schützenden Wirkungen von molekularem Wasserstoff bei sepsisassoziierter Enzephalopathie: aktueller Stand.",
      "journal": "European journal of pharmacology",
      "authors": "Dumbuya et al.",
      "author_search": "dumbuya dumbuya",
      "doi": "10.1016/j.ejphar.2026.178693",
      "doi_url": "https://doi.org/10.1016/j.ejphar.2026.178693",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41747800/",
      "url": "https://h2medicine.org/studies/study-dumbuya-2026-protective-sepsis-associated-encephalopathy/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver",
        "neurology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "41641928",
      "year": 2026,
      "title": "New progress in hydrogen-synergistic diagnostic and therapeutic nanoplatforms for tumor treatment.",
      "title_en": null,
      "title_de": "Neue Fortschritte bei wasserstoff-synergistischen diagnostischen und therapeutischen Nanoplattformen für die Tumorbehandlung.",
      "journal": "Biomaterials science",
      "authors": "Shi et al.",
      "author_search": "shi shi",
      "doi": "10.1039/d5bm01802a",
      "doi_url": "https://doi.org/10.1039/d5bm01802a",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41641928/",
      "url": "https://h2medicine.org/studies/study-shi-2026-progress-synergistic-diagnostic-therapeutic/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "41496215",
      "year": 2026,
      "title": "Revisiting molecular hydrogen signaling in mitochondria: Is the Rieske protein the entry point or a downstream sentinel?",
      "title_en": null,
      "title_de": "Erneute Betrachtung der molekularen Wasserstoff-Signalübertragung in Mitochondrien: Ist das Rieske-Protein der Eintrittspunkt oder ein nachgeschalteter Wächter?",
      "journal": "Redox biology",
      "authors": "Ostojic",
      "author_search": "ostojic ostojic",
      "doi": "10.1016/j.redox.2026.104003",
      "doi_url": "https://doi.org/10.1016/j.redox.2026.104003",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41496215/",
      "url": "https://h2medicine.org/studies/study-ostojic-2026-revisiting-signaling-mitochondria-rieske/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "41482991",
      "year": 2026,
      "title": "Medical Gases as Emerging Regulators of Paediatric Endocrine and Neurodevelopmental Pathways: A Mini-Review.",
      "title_en": null,
      "title_de": "Medizinische Gase als aufkommende Regulatoren pädiatrischer endokriner und neuronaler Entwicklungspfade: Ein Mini-Review",
      "journal": "Acta paediatrica (Oslo, Norway : 1992)",
      "authors": "Paparella et al.",
      "author_search": "paparella paparella",
      "doi": "10.1111/apa.70429",
      "doi_url": "https://doi.org/10.1111/apa.70429",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41482991/",
      "url": "https://h2medicine.org/studies/study-paparella-2026-medical-gases-emerging-regulators/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver",
        "neurology",
        "eye",
        "joints-rheumatology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "41449652",
      "year": 2026,
      "title": "Emerging Clinical Applications for Molecular Hydrogen.",
      "title_en": null,
      "title_de": "Aufkommende klinische Anwendungen für molekularen Wasserstoff",
      "journal": "Respiratory care",
      "authors": "Nguyen Puente et al.",
      "author_search": "nguyen puente nguyen puente",
      "doi": "10.1177/19433654251398759",
      "doi_url": "https://doi.org/10.1177/19433654251398759",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41449652/",
      "url": "https://h2medicine.org/studies/study-nguyenpuente-2026-emerging-applications/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "liver",
        "neurology",
        "cardiovascular",
        "cancer",
        "respiratory",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "41260719",
      "year": 2026,
      "title": "Gas Therapies for Neuro-Protection.",
      "title_en": null,
      "title_de": "Gastherapien zur Neuroprotektion",
      "journal": "Critical care clinics",
      "authors": "Merigo et al.",
      "author_search": "merigo merigo",
      "doi": "10.1016/j.ccc.2025.08.004",
      "doi_url": "https://doi.org/10.1016/j.ccc.2025.08.004",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41260719/",
      "url": "https://h2medicine.org/studies/study-merigo-2026-therapies-neuro-protection/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "neurology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "41232804",
      "year": 2026,
      "title": "Advances in hydrogen delivery strategies for therapeutic applications.",
      "title_en": null,
      "title_de": "Fortschritte bei Strategien zur Wasserstoff-Verabreichung für therapeutische Anwendungen",
      "journal": "Advanced drug delivery reviews",
      "authors": "Nguyen et al.",
      "author_search": "nguyen nguyen",
      "doi": "10.1016/j.addr.2025.115734",
      "doi_url": "https://doi.org/10.1016/j.addr.2025.115734",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41232804/",
      "url": "https://h2medicine.org/studies/study-nguyen-2026-advances-delivery-strategies-therapeutic/",
      "methods": [
        "inhalation",
        "saline-iv",
        "drinking-hrw"
      ],
      "indications": [
        "liver",
        "cancer",
        "skin-aging",
        "immune-system",
        "oxidative-stress",
        "fundamentals-safety"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "41144865",
      "year": 2026,
      "title": "Stimuli-Responsive Hydrogen Production from Nanomaterials: Design, Regulation and Biomedical Applications.",
      "title_en": null,
      "title_de": "Stimuli-responsive Wasserstoffproduktion aus Nanomaterialien: Design, Regulation und biomedizinische Anwendungen",
      "journal": "Advanced healthcare materials",
      "authors": "Pan et al.",
      "author_search": "pan pan",
      "doi": "10.1002/adhm.202503077",
      "doi_url": "https://doi.org/10.1002/adhm.202503077",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41144865/",
      "url": "https://h2medicine.org/studies/study-pan-2026-stimuli-responsive-production-nanomaterials/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "liver",
        "neurology",
        "cardiovascular",
        "cancer",
        "skin-aging",
        "immune-system",
        "fundamentals-safety"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "40826940",
      "year": 2026,
      "title": "Molecular hydrogen and kidney diseases: a scoping review based on scientometry and data analytics.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff und Nierenerkrankungen: eine Scoping-Review auf Basis von Szientometrie und Datenanalytik",
      "journal": "Medical gas research",
      "authors": "Viana et al.",
      "author_search": "viana viana",
      "doi": "10.4103/mgr.medgasres-d-25-00047",
      "doi_url": "https://doi.org/10.4103/mgr.medgasres-d-25-00047",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40826940/",
      "url": "https://h2medicine.org/studies/study-viana-2026-kidney-diseases-scoping-review/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "kidney-dialysis",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "41401441",
      "year": 2026,
      "title": "Sixty-minute inhalation of molecular hydrogen decreases blood oxygen saturation but does not alter autonomic cardiac regulation at rest in healthy females: a randomized, double-blind, placebo-controlled crossover study",
      "title_en": null,
      "title_de": "Sechzigminütige Inhalation von molekularem Wasserstoff senkt die Blutsauerstoffsättigung, verändert aber die autonome Herzregulation in Ruhe bei gesunden Frauen nicht: eine randomisierte, doppelblinde, placebokontrollierte Crossover-Studie",
      "journal": "Canadian Journal of Physiology and Pharmacology",
      "authors": "Grepl et al.",
      "author_search": "grepl grepl",
      "doi": "10.1139/cjpp-2025-0228",
      "doi_url": "https://doi.org/10.1139/cjpp-2025-0228",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41401441/",
      "url": "https://h2medicine.org/studies/study-grepl-2026-60-minute-inhalation-blood-oxygen-saturation-cardiac-regulation/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "fundamentals",
        "cardiovascular",
        "womens-health"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "41754211",
      "year": 2026,
      "title": "Redox Water Consumption Attenuates Exercise-Induced Inflammation and Oxidative Stress in Physically Active Adults: A Randomized Controlled Trial",
      "title_en": null,
      "title_de": "Der Konsum von Redox-Wasser dämpft belastungsbedingte Entzündung und oxidativen Stress bei körperlich aktiven Erwachsenen: eine randomisierte kontrollierte Studie",
      "journal": "Nutrients",
      "authors": "Stolecka-Warzecha et al.",
      "author_search": "stolecka-warzecha stolecka-warzecha",
      "doi": "10.3390/nu18040694",
      "doi_url": "https://doi.org/10.3390/nu18040694",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41754211/",
      "url": "https://h2medicine.org/studies/study-stolecka-warzecha-2026-redox-water-exercise-inflammation-oxidative-stress/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "oxidative-stress",
        "immune-system"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "41545661",
      "year": 2026,
      "title": "Exploratory Evaluation of Hydrogen-Rich Water Therapy for Keloid Management: A Double-Blinded Randomized Pilot Trial",
      "title_en": null,
      "title_de": "Explorative Evaluation einer Therapie mit wasserstoffreichem Wasser zur Behandlung von Keloiden: eine doppelblinde, randomisierte Pilotstudie",
      "journal": "Aesthetic Plastic Surgery",
      "authors": "Kuang et al.",
      "author_search": "kuang kuang",
      "doi": "10.1007/s00266-025-05512-5",
      "doi_url": "https://doi.org/10.1007/s00266-025-05512-5",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41545661/",
      "url": "https://h2medicine.org/studies/study-kuang-2026-keloid-management-pilot-trial/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "skin-aging",
        "oxidative-stress",
        "immune-system"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "41859790",
      "year": 2026,
      "title": "The combined use of inhaled nitric oxide and molecular hydrogen in patients with post-COVID-19 syndrome",
      "title_en": null,
      "title_de": "Der kombinierte Einsatz von inhaliertem Stickstoffmonoxid und molekularem Wasserstoff bei Patienten mit Post-COVID-19-Syndrom",
      "journal": "Terapevticheskii arkhiv",
      "authors": "Pozdnyakova et al.",
      "author_search": "pozdnyakova pozdnyakova",
      "doi": "10.26442/00403660.2026.03.203537",
      "doi_url": "https://doi.org/10.26442/00403660.2026.03.203537",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41859790/",
      "url": "https://h2medicine.org/studies/study-pozdnyakova-2026-inhaled-nitric-oxide-post-covid-19-syndrome/",
      "methods": [
        "inhalation",
        "bath-topical"
      ],
      "indications": [
        "respiratory",
        "oxidative-stress",
        "immune-system"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "42139605",
      "year": 2026,
      "title": "Hydration bioanalyses of the effects of hydrogen-rich water (HRW).",
      "title_en": null,
      "title_de": "Hydratations-Bioanalysen der Wirkungen von wasserstoffreichem Wasser (HRW)",
      "journal": "Wiadomosci lekarskie (Warsaw, Poland : 1960)",
      "authors": "Pesotskaya et al.",
      "author_search": "pesotskaya pesotskaya",
      "doi": "10.36740/wlek/218738",
      "doi_url": "https://doi.org/10.36740/wlek/218738",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/42139605/",
      "url": "https://h2medicine.org/studies/study-pesotskaya-2026-hydration-bioanalyses-hrw/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "kidney-dialysis"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "42049414",
      "year": 2026,
      "title": "Adjunctive Molecular Hydrogen Capsule Therapy in Empyema Complicated by Chronic Inflammatory Demyelinating Polyneuropathy: A Case Report.",
      "title_en": null,
      "title_de": "Adjunktive Therapie mit molekularem Wasserstoff in Kapselform bei Empyem mit komplizierender chronischer inflammatorischer demyelinisierender Polyneuropathie: Ein Fallbericht",
      "journal": "In vivo (Athens, Greece)",
      "authors": "Li et al.",
      "author_search": "li li",
      "doi": "10.21873/invivo.14337",
      "doi_url": "https://doi.org/10.21873/invivo.14337",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/42049414/",
      "url": "https://h2medicine.org/studies/study-li-2026-adjunctive-capsule-empyema-complicated/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "neurology",
        "respiratory",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "42049119",
      "year": 2026,
      "title": "Hydrogen gas inhalation alleviated cerebral ischemia/reperfusion injury by regulating mitophagy in SH-SY5Y cells and mice via PTEN-induced kinase 1/Parkin pathway.",
      "title_en": null,
      "title_de": "Wasserstoffgas-Inhalation linderte zerebrale Ischämie-/Reperfusionsschäden durch Regulierung der Mitophagie in SH-SY5Y-Zellen und Mäusen über den PTEN-induzierten Kinase-1/Parkin-Signalweg.",
      "journal": "Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1016/j.jstrokecerebrovasdis.2026.108645",
      "doi_url": "https://doi.org/10.1016/j.jstrokecerebrovasdis.2026.108645",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/42049119/",
      "url": "https://h2medicine.org/studies/study-wang-2026-inhalation-alleviated-cerebral-ischemia/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "neurology",
        "cardiovascular",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "42035551",
      "year": 2026,
      "title": "Molecular hydrogen suppresses gut inflammation and pyroptosis in ulcerative colitis through promoting PKM2 lactylation to block NLRP3 inflammasome activation.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff unterdrückt Darmentzündung und Pyroptose bei Colitis ulcerosa durch Förderung der PKM2-Laktylierung zur Blockierung der NLRP3-Inflammasom-Aktivierung.",
      "journal": "International immunopharmacology",
      "authors": "Yang et al.",
      "author_search": "yang yang",
      "doi": "10.1016/j.intimp.2026.116726",
      "doi_url": "https://doi.org/10.1016/j.intimp.2026.116726",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/42035551/",
      "url": "https://h2medicine.org/studies/study-yang-2026-suppresses-gut-inflammation-pyroptosis/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "immune-system",
        "fundamentals-safety"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "41986239",
      "year": 2026,
      "title": "Self-Adaptive Hydrogen Nano-Delivery System in Glaucoma Management: Synergistic Antioxidation and Anti-inflammation Therapeutic Strategy.",
      "title_en": null,
      "title_de": "Selbstadaptives Wasserstoff-Nanoabgabesystem im Glaukom-Management: Eine synergistische antioxidative und entzündungshemmende therapeutische Strategie",
      "journal": "ACS nano",
      "authors": "Zhu et al.",
      "author_search": "zhu zhu",
      "doi": "10.1021/acsnano.6c01611",
      "doi_url": "https://doi.org/10.1021/acsnano.6c01611",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41986239/",
      "url": "https://h2medicine.org/studies/study-zhu-2026-self-adaptive-nano-delivery/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver",
        "eye",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "41931901",
      "year": 2026,
      "title": "Optimization of lens size and ion source parameters for gas chromatography/mass spectrometry-based metabolomics using hydrogen as a carrier gas.",
      "title_en": null,
      "title_de": "Optimierung der Linsengröße und der Ionenquellenparameter für gaschromatographie-/massenspektrometriebasierte Metabolomik unter Verwendung von Wasserstoff als Trägergas",
      "journal": "Journal of chromatography. A",
      "authors": "Sato et al.",
      "author_search": "sato sato",
      "doi": "10.1016/j.chroma.2026.466945",
      "doi_url": "https://doi.org/10.1016/j.chroma.2026.466945",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41931901/",
      "url": "https://h2medicine.org/studies/study-sato-2026-optimization-lens-size-ion/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cancer"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "41923649",
      "year": 2026,
      "title": "The Far Side of Carboranes: Anticancer Active Monocations and Ambiently Stable Dications.",
      "title_en": null,
      "title_de": "Die abgewandte Seite der Carborane: antikanzerogen aktive Monokationen und umgebungsstabile Dikationen",
      "journal": "Angewandte Chemie (International ed. in English)",
      "authors": "Němec et al.",
      "author_search": "němec němec",
      "doi": "10.1002/anie.202521595",
      "doi_url": "https://doi.org/10.1002/anie.202521595",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41923649/",
      "url": "https://h2medicine.org/studies/study-nemec-2026-far-side-carboranes-anticancer/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "41906653",
      "year": 2026,
      "title": "Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via Promoting Mitophagy.",
      "title_en": null,
      "title_de": "Wasserstoffangereicherter Hyaluronsäure-Wundverband verbessert das diabetische Fußulkus durch Förderung der Mitophagie",
      "journal": "Journal of diabetes",
      "authors": "Xu et al.",
      "author_search": "xu xu",
      "doi": "10.1111/1753-0407.70209",
      "doi_url": "https://doi.org/10.1111/1753-0407.70209",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41906653/",
      "url": "https://h2medicine.org/studies/study-xu-2026-enriched-hyaluronic-acid-dressing/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "diabetes",
        "cardiovascular",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "41799190",
      "year": 2026,
      "title": "Molecular hydrogen triggers TRPC4-TRPC4AP-dependent reversible calcium transients via extracellular influx.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff löst TRPC4-TRPC4AP-abhängige reversible Calcium-Transienten über extrazellulären Einstrom aus",
      "journal": "Theranostics",
      "authors": "Zhao et al.",
      "author_search": "zhao zhao",
      "doi": "10.7150/thno.124352",
      "doi_url": "https://doi.org/10.7150/thno.124352",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41799190/",
      "url": "https://h2medicine.org/studies/study-zhao-2026-triggers-trpc4-trpc4ap-dependent/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "liver",
        "neurology",
        "skin-aging"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "41760342",
      "year": 2026,
      "title": "Adjunctive Molecular Hydrogen Therapy Modulates T Cell Markers and Reduces Anti-Ro Antibody in Refractory Oral Ulcers of Behçet's Disease and Sjögren's Syndrome: A Case Report.",
      "title_en": null,
      "title_de": "Adjunktive Therapie mit molekularem Wasserstoff moduliert T-Zell-Marker und reduziert Anti-Ro-Antikörper bei refraktären oralen Ulzera des Morbus Behçet und des Sjögren-Syndroms: Ein Fallbericht",
      "journal": "In vivo (Athens, Greece)",
      "authors": "Lin et al.",
      "author_search": "lin lin",
      "doi": "10.21873/invivo.14274",
      "doi_url": "https://doi.org/10.21873/invivo.14274",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41760342/",
      "url": "https://h2medicine.org/studies/study-lin-2026-adjunctive-modulates-cell-markers/",
      "methods": [
        "saline-iv",
        "drinking-hrw"
      ],
      "indications": [
        "cardiovascular",
        "joints-rheumatology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "41752368",
      "year": 2026,
      "title": "Ru-Based NSAIDs as Potential Anticancer Therapeutics.",
      "title_en": null,
      "title_de": "Ru-basierte NSAR als potenzielle antikanzerogene Therapeutika",
      "journal": "Molecules (Basel, Switzerland)",
      "authors": "Bordoni et al.",
      "author_search": "bordoni bordoni",
      "doi": "10.3390/molecules31040589",
      "doi_url": "https://doi.org/10.3390/molecules31040589",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41752368/",
      "url": "https://h2medicine.org/studies/study-bordoni-2026-nsaids-anticancer-therapeutics/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "41749059",
      "year": 2026,
      "title": "Transcriptome-Based Evaluation of Hydrogen Gas Effects for Preventing UVA-Induced Photoaging Using an Artificial Skin Model.",
      "title_en": null,
      "title_de": "Transkriptombasierte Bewertung der Wirkungen von Wasserstoffgas zur Vorbeugung von UVA-induzierter Photoalterung anhand eines künstlichen Hautmodells",
      "journal": "Geriatrics & gerontology international",
      "authors": "Kiyoi et al.",
      "author_search": "kiyoi kiyoi",
      "doi": "10.1111/ggi.70401",
      "doi_url": "https://doi.org/10.1111/ggi.70401",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41749059/",
      "url": "https://h2medicine.org/studies/study-kiyoi-2026-transcriptome-preventing-uva-induced/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "skin-aging",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "41709731",
      "year": 2026,
      "title": "MXene-Engineered MgB2 Nanoprodrugs with Acid-Responsive Hydrogen Evolution for Cooperative Photothermal Cancer Ablation.",
      "title_en": null,
      "title_de": "MXene-konstruierte MgB₂-Nanoprodrugs mit säureresponsiver Wasserstoffentwicklung für kooperative photothermische Krebsablation",
      "journal": "ACS applied materials & interfaces",
      "authors": "Li et al.",
      "author_search": "li li",
      "doi": "10.1021/acsami.5c25581",
      "doi_url": "https://doi.org/10.1021/acsami.5c25581",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41709731/",
      "url": "https://h2medicine.org/studies/study-li-2026-mxene-engineered-mgb2-nanoprodrugs/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cancer",
        "skin-aging",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "41702867",
      "year": 2026,
      "title": "Electrolyzed Hydrogen Water Improves Chemosensitivity to Anticancer Drugs by Potently Suppressing Autophagy.",
      "title_en": null,
      "title_de": "Elektrolysiertes Wasserstoffwasser verbessert die Chemosensitivität gegenüber Antikrebsmedikamenten durch starke Unterdrückung der Autophagie",
      "journal": "Journal of cellular and molecular medicine",
      "authors": "Yano et al.",
      "author_search": "yano yano",
      "doi": "10.1111/jcmm.71011",
      "doi_url": "https://doi.org/10.1111/jcmm.71011",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41702867/",
      "url": "https://h2medicine.org/studies/study-yano-2026-electrolyzed-improves-chemosensitivity-anticancer/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "cancer",
        "fundamentals-safety"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "41697782",
      "year": 2026,
      "title": "Sub-nano molybdenum oxide nanorings as amplified atomic efficiency sonosensitizers for highly efficient sonodynamic tumor ablation.",
      "title_en": null,
      "title_de": "Sub-Nano-Molybdänoxid-Nanoringe als Sonosensibilisatoren mit verstärkter atomarer Effizienz für hocheffiziente sonodynamische Tumorablation",
      "journal": "Nanoscale",
      "authors": "Zhang et al.",
      "author_search": "zhang zhang",
      "doi": "10.1039/d5nr05289k",
      "doi_url": "https://doi.org/10.1039/d5nr05289k",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41697782/",
      "url": "https://h2medicine.org/studies/study-zhang-2026-sub-nano-molybdenum-oxide/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "41655909",
      "year": 2026,
      "title": "A hydrogen generator enhances immunogenic transarterial chemoembolization in hepatocellular carcinoma.",
      "title_en": null,
      "title_de": "Ein Wasserstoffgenerator verstärkt die immunogene transarterielle Chemoembolisation beim hepatozellulären Karzinom",
      "journal": "Journal of controlled release : official journal of the Controlled Release Society",
      "authors": "Cao et al.",
      "author_search": "cao cao",
      "doi": "10.1016/j.jconrel.2026.114694",
      "doi_url": "https://doi.org/10.1016/j.jconrel.2026.114694",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41655909/",
      "url": "https://h2medicine.org/studies/study-cao-2026-generator-enhances-immunogenic-transarterial/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "liver",
        "cardiovascular",
        "cancer",
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "41582106",
      "year": 2026,
      "title": "Hydrogen inhalation is associated with a transient rightward shift in prefrontal oxyhemoglobin asymmetry and autonomic modulation.",
      "title_en": null,
      "title_de": "Wasserstoff-Inhalation ist mit einer vorübergehenden rechtsgerichteten Verschiebung der präfrontalen Oxyhämoglobin-Asymmetrie und autonomer Modulation assoziiert",
      "journal": "Scientific reports",
      "authors": "Moriya et al.",
      "author_search": "moriya moriya",
      "doi": "10.1038/s41598-026-36599-8",
      "doi_url": "https://doi.org/10.1038/s41598-026-36599-8",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41582106/",
      "url": "https://h2medicine.org/studies/study-moriya-2026-inhalation-associated-transient-rightward/",
      "methods": [
        "inhalation",
        "bath-topical"
      ],
      "indications": [
        "liver",
        "sports-exercise",
        "neurology",
        "cardiovascular",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "41580925",
      "year": 2026,
      "title": "Synergistic Calcium Overload and Hydrogen Release Potentiate Robust Antitumor Immunity.",
      "title_en": null,
      "title_de": "Synergistische Calcium-Überladung und Wasserstofffreisetzung verstärken eine robuste Antitumor-Immunität",
      "journal": "Advanced healthcare materials",
      "authors": "Liang et al.",
      "author_search": "liang liang",
      "doi": "10.1002/adhm.202505332",
      "doi_url": "https://doi.org/10.1002/adhm.202505332",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41580925/",
      "url": "https://h2medicine.org/studies/study-liang-2026-synergistic-calcium-overload-release/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "liver",
        "cancer",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "41533764",
      "year": 2026,
      "title": "Hydrogen ameliorates psoriasis-like skin inflammation via inhibiting the cGAS-STING pathway.",
      "title_en": null,
      "title_de": "Wasserstoff lindert psoriasisartige Hautentzündung durch Hemmung des cGAS-STING-Signalwegs",
      "journal": "Clinical and experimental immunology",
      "authors": "Wu et al.",
      "author_search": "wu wu",
      "doi": "10.1093/cei/uxaf081",
      "doi_url": "https://doi.org/10.1093/cei/uxaf081",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41533764/",
      "url": "https://h2medicine.org/studies/study-wu-2026-ameliorates-psoriasis-like-skin/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "41482402",
      "year": 2026,
      "title": "Rhupus Syndrome With Multiple Drug Intolerances Managed by Reduced-dose Rituximab and Adjunctive Molecular Hydrogen Therapy: A Case Report.",
      "title_en": null,
      "title_de": "Rhupus-Syndrom mit multiplen Arzneimittelunverträglichkeiten, behandelt mit dosisreduziertem Rituximab und adjunktiver Therapie mit molekularem Wasserstoff: Ein Fallbericht",
      "journal": "In vivo (Athens, Greece)",
      "authors": "Tsai et al.",
      "author_search": "tsai tsai",
      "doi": "10.21873/invivo.14221",
      "doi_url": "https://doi.org/10.21873/invivo.14221",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41482402/",
      "url": "https://h2medicine.org/studies/study-tsai-2026-rhupus-syndrome-multiple-drug/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "cardiovascular",
        "joints-rheumatology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "41482388",
      "year": 2026,
      "title": "Adjuvant Molecular Hydrogen Therapy in SLE-associated Pulmonary Arterial Hypertension: A Case Report on Immunomodulatory Effects on Regulatory and Effector Lymphocytes.",
      "title_en": null,
      "title_de": "Adjuvante Therapie mit molekularem Wasserstoff bei SLE-assoziierter pulmonalarterieller Hypertonie: Ein Fallbericht über immunmodulatorische Effekte auf regulatorische und Effektor-Lymphozyten",
      "journal": "In vivo (Athens, Greece)",
      "authors": "Liu et al.",
      "author_search": "liu liu",
      "doi": "10.21873/invivo.14220",
      "doi_url": "https://doi.org/10.21873/invivo.14220",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41482388/",
      "url": "https://h2medicine.org/studies/study-liu-2026-adjuvant-sle-associated-pulmonary/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "neurology",
        "cardiovascular",
        "respiratory",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "41420835",
      "year": 2026,
      "title": "Pearl-Like Bioinspired Coating Enables Regulation of Mg Degradation for Osteoporotic Bone Repair.",
      "title_en": null,
      "title_de": "Perlenartige bioinspirierte Beschichtung ermöglicht die Regulierung des Mg-Abbaus für die osteoporotische Knochenheilung",
      "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
      "authors": "Zhang et al.",
      "author_search": "zhang zhang",
      "doi": "10.1002/advs.202521927",
      "doi_url": "https://doi.org/10.1002/advs.202521927",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41420835/",
      "url": "https://h2medicine.org/studies/study-zhang-2026-pearl-like-bioinspired-coating/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cardiovascular",
        "joints-rheumatology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "41308938",
      "year": 2026,
      "title": "Therapeutic potential of magnesium diboride nanosheets in PAH-associated right heart failure: Integrated multi-omics analysis reveals ferroptosis suppression via LC3/ATG5/NCOA4/FTH1 pathway.",
      "title_en": null,
      "title_de": "Therapeutisches Potenzial von Magnesiumdiborid-Nanoblättern bei PAH-assoziierter Rechtsherzinsuffizienz: Integrierte Multi-Omics-Analyse zeigt Ferroptose-Unterdrückung über den LC3/ATG5/NCOA4/FTH1-Signalweg",
      "journal": "Free radical biology & medicine",
      "authors": "Jiao et al.",
      "author_search": "jiao jiao",
      "doi": "10.1016/j.freeradbiomed.2025.11.030",
      "doi_url": "https://doi.org/10.1016/j.freeradbiomed.2025.11.030",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41308938/",
      "url": "https://h2medicine.org/studies/study-jiao-2026-therapeutic-magnesium-diboride-nanosheets/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver",
        "cardiovascular",
        "respiratory",
        "immune-system",
        "oxidative-stress",
        "fundamentals-safety"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "41198323",
      "year": 2026,
      "title": "Synergistic stretching-annealing and salting-out enabling ultrastrong, ultratough anisotropic bacterial cellulose conductive hydrogels for bioelectric sensors.",
      "title_en": null,
      "title_de": "Synergistisches Strecken-Tempern und Aussalzen ermöglichen ultrastarke, ultrazähe anisotrope leitfähige Hydrogele aus bakterieller Cellulose für bioelektrische Sensoren",
      "journal": "Carbohydrate polymers",
      "authors": "Lei et al.",
      "author_search": "lei lei",
      "doi": "10.1016/j.carbpol.2025.124513",
      "doi_url": "https://doi.org/10.1016/j.carbpol.2025.124513",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41198323/",
      "url": "https://h2medicine.org/studies/study-lei-2026-synergistic-stretching-annealing-salting/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise",
        "cardiovascular"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "40944582",
      "year": 2026,
      "title": "Tumor Microenvironment-Responsive Hydrogen-Generating Zn-Doped ReZIF-8 Nanoplatform for Enhanced Tumor Suppression.",
      "title_en": null,
      "title_de": "Tumormikroumgebungs-responsive wasserstofferzeugende Zn-dotierte ReZIF-8-Nanoplattform zur verstärkten Tumorunterdrückung",
      "journal": "Advanced healthcare materials",
      "authors": "Qin et al.",
      "author_search": "qin qin",
      "doi": "10.1002/adhm.202502489",
      "doi_url": "https://doi.org/10.1002/adhm.202502489",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40944582/",
      "url": "https://h2medicine.org/studies/study-qin-2026-tumor-microenvironment-responsive-generating/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "cancer",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "41382996",
      "year": 2025,
      "title": "[Mechanisms and protective strategies for astronaut skin injury in deep space environments].",
      "title_en": null,
      "title_de": "Mechanismen und Schutzstrategien für Hautverletzungen von Astronauten in Tiefraumumgebungen",
      "journal": "Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences",
      "authors": "Xie et al.",
      "author_search": "xie xie",
      "doi": "10.11817/j.issn.1672-7347.2025.250443",
      "doi_url": "https://doi.org/10.11817/j.issn.1672-7347.2025.250443",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41382996/",
      "url": "https://h2medicine.org/studies/study-xie-2025-mechanisms-protective-strategies-astronaut/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "skin-aging",
        "immune-system",
        "oxidative-stress",
        "fundamentals-safety"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "41373725",
      "year": 2025,
      "title": "Exploring the Potential of Molecular Hydrogen in Different Heart Failure Models: A Review.",
      "title_en": null,
      "title_de": "Erkundung des Potenzials von molekularem Wasserstoff in verschiedenen Herzinsuffizienz-Modellen: Eine Übersichtsarbeit",
      "journal": "International journal of molecular sciences",
      "authors": "Kornieieva et al.",
      "author_search": "kornieieva kornieieva",
      "doi": "10.3390/ijms262311574",
      "doi_url": "https://doi.org/10.3390/ijms262311574",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41373725/",
      "url": "https://h2medicine.org/studies/study-kornieieva-2025-exploring-different-heart-failure/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cardiovascular",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "41285129",
      "year": 2025,
      "title": "Innovations in peritoneal dialysis fluid: biocompatible formulations and expanded therapeutic applications.",
      "title_en": null,
      "title_de": "Innovationen bei Peritonealdialyse-Flüssigkeit: biokompatible Formulierungen und erweiterte therapeutische Anwendungen",
      "journal": "Renal failure",
      "authors": "Xu et al.",
      "author_search": "xu xu",
      "doi": "10.1080/0886022x.2025.2583626",
      "doi_url": "https://doi.org/10.1080/0886022x.2025.2583626",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41285129/",
      "url": "https://h2medicine.org/studies/study-xu-2025-innovations-peritoneal-dialysis-fluid/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cardiovascular",
        "kidney-dialysis"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "41194243",
      "year": 2025,
      "title": "Molecular mechanisms associated with effects of hydrogen molecule in liver diseases: the review of current evidence.",
      "title_en": null,
      "title_de": "Molekulare Mechanismen im Zusammenhang mit den Wirkungen des Wasserstoffmoleküls bei Lebererkrankungen: eine Übersicht der aktuellen Evidenz",
      "journal": "European journal of medical research",
      "authors": "Zhu et al.",
      "author_search": "zhu zhu",
      "doi": "10.1186/s40001-025-03347-z",
      "doi_url": "https://doi.org/10.1186/s40001-025-03347-z",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41194243/",
      "url": "https://h2medicine.org/studies/study-zhu-2025-mechanisms-associated-molecule-liver/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "metabolic",
        "liver",
        "cancer",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "40619605",
      "year": 2025,
      "title": "Delivery of Molecular Hydrogen for Precision Immunomodulation: Mechanisms, Detection Methods, and Applications.",
      "title_en": null,
      "title_de": "Verabreichung von molekularem Wasserstoff zur präzisen Immunmodulation: Mechanismen, Nachweismethoden und Anwendungen",
      "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
      "authors": "Li et al.",
      "author_search": "li li",
      "doi": "10.1002/advs.202500283",
      "doi_url": "https://doi.org/10.1002/advs.202500283",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40619605/",
      "url": "https://h2medicine.org/studies/study-li-2025-delivery-precision-immunomodulation-mechanisms/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "40569354",
      "year": 2025,
      "title": "Molecular hydrogen as a novel regulator of cellular pyroptosis: mechanistic insights and therapeutic implications.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff als neuartiger Regulator der zellulären Pyroptose: mechanistische Einblicke und therapeutische Implikationen",
      "journal": "Molecular biology reports",
      "authors": "Ye et al.",
      "author_search": "ye ye",
      "doi": "10.1007/s11033-025-10757-z",
      "doi_url": "https://doi.org/10.1007/s11033-025-10757-z",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40569354/",
      "url": "https://h2medicine.org/studies/study-ye-2025-regulator-cellular-pyroptosis-mechanistic/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "liver",
        "neurology",
        "cancer",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "40518021",
      "year": 2025,
      "title": "Molecular hydrogen therapy: A \"democratic\" emerging strategy against aging and age-related diseases.",
      "title_en": null,
      "title_de": "Therapie mit molekularem Wasserstoff: Eine „demokratische” aufkommende Strategie gegen Alterung und altersbedingte Erkrankungen",
      "journal": "Ageing research reviews",
      "authors": "Brandi et al.",
      "author_search": "brandi brandi",
      "doi": "10.1016/j.arr.2025.102802",
      "doi_url": "https://doi.org/10.1016/j.arr.2025.102802",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40518021/",
      "url": "https://h2medicine.org/studies/study-brandi-2025-democratic-emerging-strategy-against/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "neurology",
        "cardiovascular",
        "cancer",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "40362357",
      "year": 2025,
      "title": "Molecular Hydrogen in the Treatment of Respiratory Diseases.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff bei der Behandlung von Atemwegserkrankungen",
      "journal": "International journal of molecular sciences",
      "authors": "Zajac et al.",
      "author_search": "zajac zajac",
      "doi": "10.3390/ijms26094116",
      "doi_url": "https://doi.org/10.3390/ijms26094116",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40362357/",
      "url": "https://h2medicine.org/studies/study-zajac-2025-respiratory-diseases/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise",
        "cancer",
        "respiratory",
        "immune-system",
        "allergy",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "40289982",
      "year": 2025,
      "title": "Advanced Glycation End Products and Skin Autoimmune Disorders: Pathogenic Insights into Vitiligo, Bullous Pemphigoid, and Type 1 Diabetes Mellitus.",
      "title_en": null,
      "title_de": "Advanced Glycation End Products und autoimmune Hauterkrankungen: Pathogenetische Einblicke in Vitiligo, bullöses Pemphigoid und Diabetes mellitus Typ 1",
      "journal": "Current medicinal chemistry",
      "authors": "Bjørklund et al.",
      "author_search": "bjørklund bjørklund",
      "doi": "10.2174/0109298673374335250410074811",
      "doi_url": "https://doi.org/10.2174/0109298673374335250410074811",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40289982/",
      "url": "https://h2medicine.org/studies/study-bjrklund-2025-advanced-glycation-end-products/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "diabetes",
        "metabolic",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "40243461",
      "year": 2025,
      "title": "Antioxidant Therapies as Emerging Adjuncts in Rheumatoid Arthritis: Targeting Oxidative Stress to Enhance Treatment Outcomes.",
      "title_en": null,
      "title_de": "Antioxidative Therapien als aufkommende adjunktive Behandlungen bei rheumatoider Arthritis: Oxidativer Stress als Zielstruktur zur Verbesserung der Behandlungsergebnisse",
      "journal": "International journal of molecular sciences",
      "authors": "Bilski et al.",
      "author_search": "bilski bilski",
      "doi": "10.3390/ijms26072873",
      "doi_url": "https://doi.org/10.3390/ijms26072873",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40243461/",
      "url": "https://h2medicine.org/studies/study-bilski-2025-antioxidant-therapies-emerging-adjuncts/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "joints-rheumatology",
        "immune-system",
        "oxidative-stress",
        "fundamentals-safety"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "40088576",
      "year": 2025,
      "title": "Activation, interaction and intimation of Nrf2 pathway and their mutational studies causing Nrf2 associated cancer.",
      "title_en": null,
      "title_de": "Aktivierung, Interaktion und Signalvermittlung des Nrf2-Signalwegs und ihre Mutationsstudien als Ursache Nrf2-assoziierter Krebserkrankungen",
      "journal": "Biochimica et biophysica acta. Molecular basis of disease",
      "authors": "Sahu et al.",
      "author_search": "sahu sahu",
      "doi": "10.1016/j.bbadis.2025.167764",
      "doi_url": "https://doi.org/10.1016/j.bbadis.2025.167764",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40088576/",
      "url": "https://h2medicine.org/studies/study-sahu-2025-activation-interaction-intimation-nrf2/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "40068089",
      "year": 2025,
      "title": "Molecular hydrogen: Mechanism against oxidative stress and application in periodontitis: A review.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff: Mechanismus gegen oxidativen Stress und Anwendung bei Parodontitis: Eine Übersichtsarbeit",
      "journal": "Medicine",
      "authors": "Ying et al.",
      "author_search": "ying ying",
      "doi": "10.1097/md.0000000000041800",
      "doi_url": "https://doi.org/10.1097/md.0000000000041800",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40068089/",
      "url": "https://h2medicine.org/studies/study-ying-2025-mechanism-against-oxidative-stress/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "oral-health",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "40044939",
      "year": 2025,
      "title": "Aging, vascular dysfunction, and the blood-brain barrier: unveiling the pathophysiology of stroke in older adults.",
      "title_en": null,
      "title_de": "Alterung, vaskuläre Dysfunktion und die Blut-Hirn-Schranke: Aufdeckung der Pathophysiologie des Schlaganfalls bei älteren Erwachsenen",
      "journal": "Biogerontology",
      "authors": "Alaqel et al.",
      "author_search": "alaqel alaqel",
      "doi": "10.1007/s10522-025-10209-y",
      "doi_url": "https://doi.org/10.1007/s10522-025-10209-y",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40044939/",
      "url": "https://h2medicine.org/studies/study-alaqel-2025-aging-vascular-dysfunction-blood/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "neurology",
        "cardiovascular",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "40026178",
      "year": 2025,
      "title": "The Roles of Neuroinflammation in l-DOPA-Induced Dyskinesia: Dissecting the Roles of NF-κB and TNF-α for Novel Pharmacological Therapeutic Approaches.",
      "title_en": null,
      "title_de": "Die Rolle der Neuroinflammation bei L-DOPA-induzierter Dyskinesie: Aufschlüsselung der Rollen von NF-κB und TNF-α für neuartige pharmakologische therapeutische Ansätze",
      "journal": "The European journal of neuroscience",
      "authors": "Zamanian et al.",
      "author_search": "zamanian zamanian",
      "doi": "10.1111/ejn.70034",
      "doi_url": "https://doi.org/10.1111/ejn.70034",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40026178/",
      "url": "https://h2medicine.org/studies/study-zamanian-2025-roles-neuroinflammation-dopa-induced/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "neurology",
        "skin-aging",
        "immune-system"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "40017254",
      "year": 2025,
      "title": "Exploring the Potential of H2 Therapy in Reducing Surgical Complications: A Review on Anti-inflammatory, Antioxidant, and Anti-fibrotic Mechanisms.",
      "title_en": null,
      "title_de": "Erkundung des Potenzials der H₂-Therapie zur Reduzierung chirurgischer Komplikationen: Eine Übersichtsarbeit über entzündungshemmende, antioxidative und antifibrotische Mechanismen",
      "journal": "Current pharmaceutical design",
      "authors": "Neykhonji et al.",
      "author_search": "neykhonji neykhonji",
      "doi": "10.2174/0113816128354067250211052237",
      "doi_url": "https://doi.org/10.2174/0113816128354067250211052237",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40017254/",
      "url": "https://h2medicine.org/studies/study-neykhonji-2025-exploring-reducing-surgical-complications/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "respiratory",
        "immune-system",
        "oxidative-stress",
        "fundamentals-safety"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "39810534",
      "year": 2025,
      "title": "Oral Administration of Hydrogen-rich Water: Biomedical Activities, Potential Mechanisms, and Clinical Applications.",
      "title_en": null,
      "title_de": "Orale Verabreichung von wasserstoffreichem Wasser: Biomedizinische Aktivitäten, mögliche Mechanismen und klinische Anwendungen",
      "journal": "Current pharmaceutical design",
      "authors": "Meng et al.",
      "author_search": "meng meng",
      "doi": "10.2174/0113816128330516241121150719",
      "doi_url": "https://doi.org/10.2174/0113816128330516241121150719",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39810534/",
      "url": "https://h2medicine.org/studies/study-meng-2025-oral-administration-biomedical-activities/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "metabolic",
        "cardiovascular",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "39807026",
      "year": 2025,
      "title": "Application trends of hydrogen-generating nanomaterials for the treatment of ROS-related diseases.",
      "title_en": null,
      "title_de": "Anwendungstrends wasserstofferzeugender Nanomaterialien zur Behandlung ROS-assoziierter Erkrankungen",
      "journal": "Biomaterials science",
      "authors": "Li et al.",
      "author_search": "li li",
      "doi": "10.1039/d4bm01450b",
      "doi_url": "https://doi.org/10.1039/d4bm01450b",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39807026/",
      "url": "https://h2medicine.org/studies/study-li-2025-application-trends-generating-nanomaterials/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "liver",
        "neurology",
        "cardiovascular",
        "cancer",
        "kidney-dialysis",
        "skin-aging",
        "immune-system",
        "oxidative-stress",
        "fundamentals-safety"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "39042916",
      "year": 2025,
      "title": "Hydrogen as an innovative nootropic in health and disease.",
      "title_en": null,
      "title_de": "Wasserstoff als innovatives Nootropikum bei Gesundheit und Krankheit",
      "journal": "Nutrition and health",
      "authors": "Todorović et al.",
      "author_search": "todorović todorović",
      "doi": "10.1177/02601060241266389",
      "doi_url": "https://doi.org/10.1177/02601060241266389",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39042916/",
      "url": "https://h2medicine.org/studies/study-todorovic-2025-innovative-nootropic-health-disease/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "neurology",
        "cancer",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "39923133",
      "year": 2025,
      "title": "Molecular hydrogen inhalation modulates resting metabolism in healthy females: findings from a randomized, double-blind, placebo-controlled crossover study",
      "title_en": null,
      "title_de": "Die Inhalation von molekularem Wasserstoff moduliert den Ruhe-Stoffwechsel bei gesunden Frauen: Ergebnisse einer randomisierten, doppelblinden, placebokontrollierten Crossover-Studie",
      "journal": "Medical Gas Research",
      "authors": "Grepl et al.",
      "author_search": "grepl grepl",
      "doi": "10.4103/mgr.medgasres-d-24-00085",
      "doi_url": "https://doi.org/10.4103/mgr.medgasres-d-24-00085",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39923133/",
      "url": "https://h2medicine.org/studies/study-grepl-2025-inhalation-resting-metabolism-healthy-females/",
      "methods": [
        "inhalation",
        "bath-topical"
      ],
      "indications": [
        "metabolic",
        "oxidative-stress"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "40376695",
      "year": 2025,
      "title": "Hydrogen-Rich Water Decreases Muscle Damage and Improves Power Endurance in Elite Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial",
      "title_en": null,
      "title_de": "Wasserstoffreiches Wasser verringert Muskelschäden und verbessert die Kraftausdauer bei Spitzensportlern: eine randomisierte, doppelblinde, placebokontrollierte Studie",
      "journal": "Journal of Lifestyle Medicine",
      "authors": "Ogannisyan et al.",
      "author_search": "ogannisyan ogannisyan",
      "doi": "10.15280/jlm.2025.15.1.8",
      "doi_url": "https://doi.org/10.15280/jlm.2025.15.1.8",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40376695/",
      "url": "https://h2medicine.org/studies/study-ogannisyan-2025-hydrogen-rich-water-muscle-damage-power-endurance-elite-athletes/",
      "methods": [
        "tablets",
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "oxidative-stress"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "40525414",
      "year": 2025,
      "title": "The effects of drinking hydrogen-rich water for six weeks on exercise-related biomarkers in exercise-naïve men and women over 50 years following resistance training program: a randomized controlled pilot trial",
      "title_en": null,
      "title_de": "Die Effekte des sechswöchigen Trinkens von wasserstoffreichem Wasser auf belastungsbezogene Biomarker bei sportungewohnten Männern und Frauen über 50 Jahren nach einem Krafttrainingsprogramm: eine randomisierte, kontrollierte Pilotstudie",
      "journal": "Research in Sports Medicine",
      "authors": "Kuzmanovic et al.",
      "author_search": "kuzmanovic kuzmanovic",
      "doi": "10.1080/15438627.2025.2521474",
      "doi_url": "https://doi.org/10.1080/15438627.2025.2521474",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40525414/",
      "url": "https://h2medicine.org/studies/study-kuzmanovic-2025-drinking-hrw-exercise-biomarkers-over-50-resistance/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "metabolic",
        "oxidative-stress"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "40731803",
      "year": 2025,
      "title": "Pre-Exercise Ingestion of Hydrogen-Rich Cold Water Enhances Endurance Performance and Lactate Response in Heat",
      "title_en": null,
      "title_de": "Die Einnahme von wasserstoffreichem Kaltwasser vor dem Sport verbessert die Ausdauerleistung und die Laktatreaktion bei Hitze",
      "journal": "Medicina (Kaunas)",
      "authors": "Khlifi et al.",
      "author_search": "khlifi khlifi",
      "doi": "10.3390/medicina61071173",
      "doi_url": "https://doi.org/10.3390/medicina61071173",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40731803/",
      "url": "https://h2medicine.org/studies/study-khlifi-2025-pre-exercise-cold-water-endurance-heat/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "oxidative-stress"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "40731927",
      "year": 2025,
      "title": "The Effects of 8-Week Hydrogen-Rich Water Consumption on Appetite, Body Composition, Sleep Quality, and Circulating Glucagon-like Peptide-1 in Obese Men and Women (HYDRAPPET): A Randomized Controlled Trial",
      "title_en": null,
      "title_de": "Die Effekte des achtwöchigen Konsums von wasserstoffreichem Wasser auf Appetit, Körperzusammensetzung, Schlafqualität und zirkulierendes Glucagon-like Peptide-1 bei adipösen Männern und Frauen (HYDRAPPET): eine randomisierte kontrollierte Studie",
      "journal": "Medicina (Kaunas)",
      "authors": "Todorovic et al.",
      "author_search": "todorovic todorovic",
      "doi": "10.3390/medicina61071299",
      "doi_url": "https://doi.org/10.3390/medicina61071299",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40731927/",
      "url": "https://h2medicine.org/studies/study-todorovic-2025-8-week-appetite-body-composition-sleep-glp-1-obese/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "metabolic",
        "neurology"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "40922182",
      "year": 2025,
      "title": "Hydrogen-rich water supplementation attenuates oxidative stress and inflammation in chronic high-altitude disease patients: A double-blind randomized placebo-controlled study",
      "title_en": null,
      "title_de": "Die Supplementierung mit wasserstoffreichem Wasser dämpft oxidativen Stress und Entzündung bei Patienten mit chronischer Höhenkrankheit: eine doppelblinde, randomisierte, placebokontrollierte Studie",
      "journal": "Food Research International",
      "authors": "Zhang et al.",
      "author_search": "zhang zhang",
      "doi": "10.1016/j.foodres.2025.117118",
      "doi_url": "https://doi.org/10.1016/j.foodres.2025.117118",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40922182/",
      "url": "https://h2medicine.org/studies/study-zhang-2025-high-altitude-disease-oxidative-stress-inflammation/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "oxidative-stress",
        "immune-system",
        "respiratory"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "41384523",
      "year": 2025,
      "title": "[Effectiveness of using non-drug technologies to increase stress resistance in persons with extreme work profile and susceptible for professional burnout].",
      "title_en": null,
      "title_de": "Wirksamkeit nichtmedikamentöser Technologien zur Steigerung der Stressresistenz bei Personen mit extremem Arbeitsprofil und Anfälligkeit für berufliches Burnout",
      "journal": "Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury",
      "authors": "Korchazhkina et al.",
      "author_search": "korchazhkina korchazhkina",
      "doi": "10.17116/kurort202510205291",
      "doi_url": "https://doi.org/10.17116/kurort202510205291",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41384523/",
      "url": "https://h2medicine.org/studies/study-korchazhkina-2025-non-drug-technologies-increase/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "40327618",
      "year": 2025,
      "title": "[Efficiency and safety of the integrated use of medical gases thermal heliox, nitric oxide and molecular hydrogen in patients with exacerbation of chronic obstructive pulmonary disease complicated by hypoxemic, hypercapnic respiratory failure and secondary pulmonary arterial hypertension in the post-COVID period].",
      "title_en": null,
      "title_de": "Effizienz und Sicherheit des kombinierten Einsatzes medizinischer Gase – thermisches Heliox, Stickstoffmonoxid und molekularer Wasserstoff – bei Patienten mit COPD-Exazerbation, respiratorischer Insuffizienz und pulmonalarterieller Hypertonie in der Post-COVID-Phase",
      "journal": "Terapevticheskii arkhiv",
      "authors": "Shogenova",
      "author_search": "shogenova shogenova",
      "doi": "10.26442/00403660.2025.03.203131",
      "doi_url": "https://doi.org/10.26442/00403660.2025.03.203131",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40327618/",
      "url": "https://h2medicine.org/studies/study-shogenova-2025-efficiency-integrated-use-medical/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver",
        "sports-exercise",
        "cardiovascular",
        "respiratory",
        "fundamentals-safety"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "41384514",
      "year": 2025,
      "title": "[Biochemical markers of stress in medical workers with occupational burnout syndrome and their dynamics in the application of physiotherapeutic factors].",
      "title_en": null,
      "title_de": "Biochemische Stressmarker bei medizinischem Personal mit berufsbedingtem Burnout-Syndrom und ihre Dynamik unter Anwendung physiotherapeutischer Faktoren",
      "journal": "Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury",
      "authors": "Kotenko et al.",
      "author_search": "kotenko kotenko",
      "doi": "10.17116/kurort202510205217",
      "doi_url": "https://doi.org/10.17116/kurort202510205217",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41384514/",
      "url": "https://h2medicine.org/studies/study-kotenko-2025-biochemical-markers-stress-medical/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "metabolic",
        "sports-exercise",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "41376217",
      "year": 2025,
      "title": "Four-dimensional data independent acquisition proteomics and metabolomics reveal mechanisms of hydrogen-rich water at Zusanli (ST36) point against triple-negative breast cancer in mice.",
      "title_en": null,
      "title_de": "Vierdimensionale datenunabhängige Akquisitions-Proteomik und -Metabolomik enthüllen Mechanismen von wasserstoffreichem Wasser am Zusanli-Punkt (ST36) gegen dreifach-negativen Brustkrebs bei Mäusen",
      "journal": "Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan",
      "authors": "Jingxuan et al.",
      "author_search": "jingxuan jingxuan",
      "doi": "10.19852/j.cnki.jtcm.20250929.002",
      "doi_url": "https://doi.org/10.19852/j.cnki.jtcm.20250929.002",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41376217/",
      "url": "https://h2medicine.org/studies/study-jingxuan-2025-four-dimensional-data-independent/",
      "methods": [
        "saline-iv",
        "drinking-hrw"
      ],
      "indications": [
        "cancer",
        "joints-rheumatology"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "41330217",
      "year": 2025,
      "title": "The Rieske iron-sulfur protein is a primary target of molecular hydrogen.",
      "title_en": null,
      "title_de": "Das Rieske-Eisen-Schwefel-Protein ist ein primäres Ziel von molekularem Wasserstoff",
      "journal": "Redox biology",
      "authors": "Negishi et al.",
      "author_search": "negishi negishi",
      "doi": "10.1016/j.redox.2025.103952",
      "doi_url": "https://doi.org/10.1016/j.redox.2025.103952",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41330217/",
      "url": "https://h2medicine.org/studies/study-negishi-2025-rieske-iron-sulfur-protein/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver",
        "sports-exercise"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "41204320",
      "year": 2025,
      "title": "Hydrogen's Feasibility and Safety as a Therapy in Extracorporeal Cardiopulmonary Resuscitation (Hydrogen-FAST): study protocol for a trial of inhaled hydrogen gas as an adjunctive therapy in refractory cardiac arrest.",
      "title_en": null,
      "title_de": "Hydrogen-FAST: Studienprotokoll für inhaliertes Wasserstoffgas als adjunktive Therapie bei refraktärem Herzstillstand (ECPR)",
      "journal": "Trials",
      "authors": "Habet et al.",
      "author_search": "habet habet",
      "doi": "10.1186/s13063-025-09217-7",
      "doi_url": "https://doi.org/10.1186/s13063-025-09217-7",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41204320/",
      "url": "https://h2medicine.org/studies/study-habet-2025-feasibility-extracorporeal-cardiopulmonary-resuscitation/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "liver",
        "neurology",
        "cardiovascular",
        "respiratory",
        "fundamentals-safety"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "41176039",
      "year": 2025,
      "title": "Hydrogen enhanced photothermal therapy for redox-regulated tumor apoptosis and immune reprogramming.",
      "title_en": null,
      "title_de": "Wasserstoffverstärkte photothermische Therapie für redox-regulierte Tumorapoptose und Immun-Reprogrammierung",
      "journal": "Acta biomaterialia",
      "authors": "Chu et al.",
      "author_search": "chu chu",
      "doi": "10.1016/j.actbio.2025.10.059",
      "doi_url": "https://doi.org/10.1016/j.actbio.2025.10.059",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41176039/",
      "url": "https://h2medicine.org/studies/study-chu-2025-enhanced-photothermal-redox-regulated/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "neurology",
        "cancer",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "41167690",
      "year": 2025,
      "title": "A Case Report of Adjuvant Molecular Hydrogen Therapy in Refractory Rheumatoid Arthritis With Atlantoaxial Subluxation.",
      "title_en": null,
      "title_de": "Ein Fallbericht über adjuvante Therapie mit molekularem Wasserstoff bei refraktärer rheumatoider Arthritis mit atlantoaxialer Subluxation",
      "journal": "In vivo (Athens, Greece)",
      "authors": "Ren et al.",
      "author_search": "ren ren",
      "doi": "10.21873/invivo.14166",
      "doi_url": "https://doi.org/10.21873/invivo.14166",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41167690/",
      "url": "https://h2medicine.org/studies/study-ren-2025-adjuvant-refractory-rheumatoid-arthritis/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "neurology",
        "skin-aging",
        "joints-rheumatology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "41167678",
      "year": 2025,
      "title": "Dynamic Immunomodulation by Hydrogen Capsule Therapy in SLE-associated Pulmonary Arterial Hypertension: A Case Report.",
      "title_en": null,
      "title_de": "Dynamische Immunmodulation durch Wasserstoff-Kapseltherapie bei SLE-assoziierter pulmonalarterieller Hypertonie: Ein Fallbericht",
      "journal": "In vivo (Athens, Greece)",
      "authors": "Liu et al.",
      "author_search": "liu liu",
      "doi": "10.21873/invivo.14165",
      "doi_url": "https://doi.org/10.21873/invivo.14165",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41167678/",
      "url": "https://h2medicine.org/studies/study-liu-2025-dynamic-immunomodulation-capsule-sle/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cardiovascular",
        "respiratory",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "41083007",
      "year": 2025,
      "title": "Transdermal hydrogen therapy for psoriasis using cavity-embedded double-conical microneedles.",
      "title_en": null,
      "title_de": "Transdermale Wasserstofftherapie bei Psoriasis unter Verwendung von hohlraumeingebetteten doppelkonischen Mikronadeln",
      "journal": "Journal of controlled release : official journal of the Controlled Release Society",
      "authors": "Zhu et al.",
      "author_search": "zhu zhu",
      "doi": "10.1016/j.jconrel.2025.114313",
      "doi_url": "https://doi.org/10.1016/j.jconrel.2025.114313",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41083007/",
      "url": "https://h2medicine.org/studies/study-zhu-2025-transdermal-psoriasis-cavity-embedded/",
      "methods": [
        "bath-topical"
      ],
      "indications": [
        "liver",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "41076526",
      "year": 2025,
      "title": "Spontaneous hydrogen-releasing nanoenzyme alleviates osteoarthritis via oxidative stress reduction and mitochondrial dysfunction reversal.",
      "title_en": null,
      "title_de": "Spontan wasserstofffreisetzendes Nanoenzym lindert Osteoarthritis durch Reduktion von oxidativem Stress und Umkehrung der mitochondrialen Dysfunktion",
      "journal": "Journal of nanobiotechnology",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1186/s12951-025-03716-0",
      "doi_url": "https://doi.org/10.1186/s12951-025-03716-0",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41076526/",
      "url": "https://h2medicine.org/studies/study-wang-2025-spontaneous-releasing-nanoenzyme-alleviates/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "skin-aging",
        "joints-rheumatology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "41063273",
      "year": 2025,
      "title": "Biomechanical analysis of biodegradable magnesium, zinc, and polylactide pins for fixation of radial head fractures.",
      "title_en": null,
      "title_de": "Biomechanische Analyse biologisch abbaubarer Stifte aus Magnesium, Zink und Polylactid zur Fixierung von Radiusköpfchenfrakturen",
      "journal": "Journal of orthopaedic surgery and research",
      "authors": "Maier et al.",
      "author_search": "maier maier",
      "doi": "10.1186/s13018-025-06346-2",
      "doi_url": "https://doi.org/10.1186/s13018-025-06346-2",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41063273/",
      "url": "https://h2medicine.org/studies/study-maier-2025-biomechanical-analysis-biodegradable-magnesium/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "sports-exercise",
        "joints-rheumatology"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "41043278",
      "year": 2025,
      "title": "Hydrogen-rich gas enhances mitochondrial membrane potential and respiratory function recovery in Caco-2 cells post-ischemia-reperfusion injury.",
      "title_en": null,
      "title_de": "Wasserstoffreiches Gas verstärkt das mitochondriale Membranpotenzial und die Erholung der Atmungsfunktion in Caco-2-Zellen nach Ischämie-Reperfusionsschaden",
      "journal": "Biochemical and biophysical research communications",
      "authors": "Seya et al.",
      "author_search": "seya seya",
      "doi": "10.1016/j.bbrc.2025.152753",
      "doi_url": "https://doi.org/10.1016/j.bbrc.2025.152753",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41043278/",
      "url": "https://h2medicine.org/studies/study-seya-2025-enhances-mitochondrial-membrane-respiratory/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "respiratory",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "41013628",
      "year": 2025,
      "title": "Research on the inhibitory effect of hydrogen gas on ovarian cancer and potential mechanisms.",
      "title_en": null,
      "title_de": "Forschung zur hemmenden Wirkung von Wasserstoffgas auf Eierstockkrebs und mögliche Mechanismen",
      "journal": "European journal of medical research",
      "authors": "Yin et al.",
      "author_search": "yin yin",
      "doi": "10.1186/s40001-025-03111-3",
      "doi_url": "https://doi.org/10.1186/s40001-025-03111-3",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41013628/",
      "url": "https://h2medicine.org/studies/study-yin-2025-research-inhibitory-ovarian-cancer/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cancer",
        "womens-health"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "40976279",
      "year": 2025,
      "title": "Hierarchical ROS-scavenging platform breaks vicious cycle of stem cell senescence, angiogenesis arrest, and immune dysregulation in diabetic wounds.",
      "title_en": null,
      "title_de": "Hierarchische ROS-eliminierende Plattform durchbricht den Teufelskreis aus Stammzellseneszenz, Angiogenese-Stillstand und Immundysregulation bei diabetischen Wunden.",
      "journal": "Journal of controlled release : official journal of the Controlled Release Society",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1016/j.jconrel.2025.114247",
      "doi_url": "https://doi.org/10.1016/j.jconrel.2025.114247",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40976279/",
      "url": "https://h2medicine.org/studies/study-wang-2025-hierarchical-ros-scavenging-platform/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "diabetes",
        "cardiovascular",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "40931918",
      "year": 2025,
      "title": "Nanobiocatalyst-Driven Spatiotemporal Hydrogen Delivery Induces Dormancy Potentiated Catalytic Tumor Therapy.",
      "title_en": null,
      "title_de": "Nanobiokatalysator-gesteuerte raumzeitliche Wasserstoffabgabe induziert dormanz-potenzierte katalytische Tumortherapie.",
      "journal": "ACS nano",
      "authors": "Cao et al.",
      "author_search": "cao cao",
      "doi": "10.1021/acsnano.5c10754",
      "doi_url": "https://doi.org/10.1021/acsnano.5c10754",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40931918/",
      "url": "https://h2medicine.org/studies/study-cao-2025-nanobiocatalyst-driven-spatiotemporal-delivery/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "liver",
        "cancer",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "40885754",
      "year": 2025,
      "title": "Pyroptosis-responsive microspheres modulate the inflammatory microenvironment to retard osteoporosis in female mice.",
      "title_en": null,
      "title_de": "Pyroptose-responsive Mikrosphären modulieren die entzündliche Mikroumgebung zur Verzögerung der Osteoporose bei weiblichen Mäusen.",
      "journal": "Nature communications",
      "authors": "Lu et al.",
      "author_search": "lu lu",
      "doi": "10.1038/s41467-025-63456-5",
      "doi_url": "https://doi.org/10.1038/s41467-025-63456-5",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40885754/",
      "url": "https://h2medicine.org/studies/study-lu-2025-pyroptosis-responsive-microspheres-modulate/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "joints-rheumatology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "40877145",
      "year": 2025,
      "title": "Immunomodulatory Effects of Molecular Hydrogen Therapy in Systemic Lupus Erythematosus With Pericarditis and Pleuritis: A Case Report.",
      "title_en": null,
      "title_de": "Immunmodulatorische Effekte der Therapie mit molekularem Wasserstoff bei systemischem Lupus erythematodes mit Perikarditis und Pleuritis: Ein Fallbericht",
      "journal": "In vivo (Athens, Greece)",
      "authors": "Tu et al.",
      "author_search": "tu tu",
      "doi": "10.21873/invivo.14103",
      "doi_url": "https://doi.org/10.21873/invivo.14103",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40877145/",
      "url": "https://h2medicine.org/studies/study-tu-2025-immunomodulatory-systemic-lupus-erythematosus/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "cardiovascular",
        "immune-system",
        "oxidative-stress",
        "fundamentals-safety"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "40874435",
      "year": 2025,
      "title": "Hydrogen attenuates the senescence of adipose-derived stem cells and enhances their myogenic differentiation via modulation of the PRDX6/SIRT1/PGC-1α signaling pathway.",
      "title_en": null,
      "title_de": "Wasserstoff dämpft die Seneszenz von aus Fettgewebe gewonnenen Stammzellen und verstärkt deren myogene Differenzierung durch Modulation des PRDX6/SIRT1/PGC-1α-Signalwegs.",
      "journal": "Human & experimental toxicology",
      "authors": "Zhang et al.",
      "author_search": "zhang zhang",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40874435/",
      "url": "https://h2medicine.org/studies/study-zhang-2025-attenuates-senescence-adipose-derived/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "metabolic",
        "sports-exercise",
        "skin-aging",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "40864154",
      "year": 2025,
      "title": "Local Delivery of Molecular Hydrogen by Fluorinated Zeolitic Imidazole Framework Nanosheets Boosts Cancer Immunotherapy.",
      "title_en": null,
      "title_de": "Lokale Verabreichung von molekularem Wasserstoff durch fluorierte zeolithische Imidazol-Gerüst-Nanoblätter verstärkt die Krebs-Immuntherapie.",
      "journal": "ACS applied materials & interfaces",
      "authors": "Liu et al.",
      "author_search": "liu liu",
      "doi": "10.1021/acsami.5c15739",
      "doi_url": "https://doi.org/10.1021/acsami.5c15739",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40864154/",
      "url": "https://h2medicine.org/studies/study-liu-2025-local-delivery-fluorinated-zeolitic/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver",
        "cancer",
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "40850177",
      "year": 2025,
      "title": "Integrating QSAR modeling, ADMET screening, molecular docking, and molecular dynamics simulations to identify potential MCF-7 inhibitors.",
      "title_en": null,
      "title_de": "Integration von QSAR-Modellierung, ADMET-Screening, molekularem Docking und Molekulardynamik-Simulationen zur Identifizierung potenzieller MCF-7-Inhibitoren.",
      "journal": "Computers in biology and medicine",
      "authors": "Valizadeh et al.",
      "author_search": "valizadeh valizadeh",
      "doi": "10.1016/j.compbiomed.2025.110972",
      "doi_url": "https://doi.org/10.1016/j.compbiomed.2025.110972",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40850177/",
      "url": "https://h2medicine.org/studies/study-valizadeh-2025-integrating-qsar-modeling-admet/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "40845957",
      "year": 2025,
      "title": "Hydrogen promoted mitochondrial autophagy and alleviated CIH-induced vascular endothelial cell senescence by regulating oxidative stress.",
      "title_en": null,
      "title_de": "Wasserstoff förderte die mitochondriale Autophagie und linderte die CIH-induzierte Seneszenz vaskulärer Endothelzellen durch Regulierung von oxidativem Stress.",
      "journal": "European journal of pharmacology",
      "authors": "Li et al.",
      "author_search": "li li",
      "doi": "10.1016/j.ejphar.2025.178078",
      "doi_url": "https://doi.org/10.1016/j.ejphar.2025.178078",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40845957/",
      "url": "https://h2medicine.org/studies/study-li-2025-promoted-mitochondrial-autophagy-alleviated/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "neurology",
        "cardiovascular",
        "respiratory",
        "skin-aging",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "40833316",
      "year": 2025,
      "title": "Nano-Bubble Hydrogen Water in Wet-Wrap Dressing Improves the Severity of Pediatric Patients With Atopic Dermatitis.",
      "title_en": null,
      "title_de": "Nanobläschen-Wasserstoffwasser im Wet-Wrap-Verband verbessert den Schweregrad bei pädiatrischen Patienten mit atopischer Dermatitis",
      "journal": "Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners",
      "authors": "Wong et al.",
      "author_search": "wong wong",
      "doi": "10.1016/j.pedhc.2025.07.005",
      "doi_url": "https://doi.org/10.1016/j.pedhc.2025.07.005",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40833316/",
      "url": "https://h2medicine.org/studies/study-wong-2025-nano-bubble-wet-wrap/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "skin-aging",
        "immune-system",
        "allergy",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "40733848",
      "year": 2025,
      "title": "3D printing combined with pH-induced 4D printed iron(III)-oxidized starch gels for controlled iron delivery and enhanced iron supplementation.",
      "title_en": null,
      "title_de": "3D-Druck kombiniert mit pH-induzierten 4D-gedruckten Gelen aus Eisen(III)-oxidierter Stärke zur kontrollierten Eisenabgabe und verbesserten Eisensupplementierung.",
      "journal": "Carbohydrate polymers",
      "authors": "Qiu et al.",
      "author_search": "qiu qiu",
      "doi": "10.1016/j.carbpol.2025.123933",
      "doi_url": "https://doi.org/10.1016/j.carbpol.2025.123933",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40733848/",
      "url": "https://h2medicine.org/studies/study-qiu-2025-printing-combined-induced-printed/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "liver",
        "sports-exercise",
        "oxidative-stress",
        "fundamentals-safety"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "40694834",
      "year": 2025,
      "title": "Hydrogen-Rich Water Consumption for Acute and Residual Fatigue After Simulated Football Matches: Protocol for a Randomized, Double-Blinded, Placebo-Controlled, Parallel Trial.",
      "title_en": null,
      "title_de": "Konsum von wasserstoffreichem Wasser gegen akute und residuale Ermüdung nach simulierten Fußballspielen: Protokoll für eine randomisierte, doppelblinde, placebokontrollierte Parallelstudie",
      "journal": "JMIR research protocols",
      "authors": "Hruby et al.",
      "author_search": "hruby hruby",
      "doi": "10.2196/69744",
      "doi_url": "https://doi.org/10.2196/69744",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40694834/",
      "url": "https://h2medicine.org/studies/study-hruby-2025-consumption-acute-residual-fatigue/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "neurology",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "40621736",
      "year": 2025,
      "title": "Magnesium hydride-induced hydrogen therapy for enhanced sonodynamic therapy.",
      "title_en": null,
      "title_de": "Magnesiumhydrid-induzierte Wasserstofftherapie zur verstärkten sonodynamischen Therapie.",
      "journal": "Materials horizons",
      "authors": "Huang et al.",
      "author_search": "huang huang",
      "doi": "10.1039/d5mh00585j",
      "doi_url": "https://doi.org/10.1039/d5mh00585j",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40621736/",
      "url": "https://h2medicine.org/studies/study-huang-2025-magnesium-hydride-induced-enhanced/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "40590161",
      "year": 2025,
      "title": "Predicting Therapeutic Response to Molecular Hydrogen in Autoimmune Diseases via Immunophenotyping.",
      "title_en": null,
      "title_de": "Vorhersage des therapeutischen Ansprechens auf molekularen Wasserstoff bei Autoimmunerkrankungen mittels Immunphänotypisierung",
      "journal": "APMIS : acta pathologica, microbiologica, et immunologica Scandinavica",
      "authors": "Lui et al.",
      "author_search": "lui lui",
      "doi": "10.1111/apm.70040",
      "doi_url": "https://doi.org/10.1111/apm.70040",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40590161/",
      "url": "https://h2medicine.org/studies/study-lui-2025-predicting-therapeutic-response-autoimmune/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "respiratory",
        "joints-rheumatology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "40579028",
      "year": 2025,
      "title": "Molecular Hydrogen Therapy in Rheumatoid Arthritis: A Case Report on the Amelioration of Methotrexate-induced Myelosuppression and Immune Modulation.",
      "title_en": null,
      "title_de": "Therapie mit molekularem Wasserstoff bei rheumatoider Arthritis: Ein Fallbericht über die Besserung der Methotrexat-induzierten Myelosuppression und Immunmodulation",
      "journal": "In vivo (Athens, Greece)",
      "authors": "Tu et al.",
      "author_search": "tu tu",
      "doi": "10.21873/invivo.14014",
      "doi_url": "https://doi.org/10.21873/invivo.14014",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40579028/",
      "url": "https://h2medicine.org/studies/study-tu-2025-rheumatoid-arthritis-amelioration-methotrexate/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "liver",
        "neurology",
        "kidney-dialysis",
        "joints-rheumatology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "40579023",
      "year": 2025,
      "title": "Molecular Hydrogen as an Adjuvant Therapy in Comorbid Sjögren's Syndrome, SLE, and ILD: A Case Report on Immune Modulation and Fatigue Reduction.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff als adjuvante Therapie bei komorbidem Sjögren-Syndrom, SLE und ILD: Ein Fallbericht über Immunmodulation und Reduktion der Ermüdung",
      "journal": "In vivo (Athens, Greece)",
      "authors": "Tsai et al.",
      "author_search": "tsai tsai",
      "doi": "10.21873/invivo.14018",
      "doi_url": "https://doi.org/10.21873/invivo.14018",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40579023/",
      "url": "https://h2medicine.org/studies/study-tsai-2025-adjuvant-comorbid-sjoegren-syndrome/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver",
        "sports-exercise",
        "respiratory",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "40295001",
      "year": 2025,
      "title": "Molecular Hydrogen Capsule Therapy for Primary Biliary Cholangitis With Elevated IgG4: A Case Report on Immune Marker Normalization.",
      "title_en": null,
      "title_de": "Therapie mit molekularem Wasserstoff in Kapselform bei primär biliärer Cholangitis mit erhöhtem IgG4: Ein Fallbericht über die Normalisierung von Immunmarkern",
      "journal": "In vivo (Athens, Greece)",
      "authors": "Lin et al.",
      "author_search": "lin lin",
      "doi": "10.21873/invivo.13968",
      "doi_url": "https://doi.org/10.21873/invivo.13968",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40295001/",
      "url": "https://h2medicine.org/studies/study-lin-2025-capsule-primary-biliary-cholangitis/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver",
        "sports-exercise",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "40259480",
      "year": 2025,
      "title": "RNA-Seq Reveals the Mechanism of Synergistic Hydrogen-Chemotherapy Based on Active Magnesium Micromotors for Inhibiting Glioblastoma Recurrence by Modulating Tumor Microenvironment.",
      "title_en": null,
      "title_de": "RNA-Seq enthüllt den Mechanismus der synergistischen Wasserstoff-Chemotherapie auf Basis aktiver Magnesium-Mikromotoren zur Hemmung des Glioblastom-Rezidivs durch Modulation der Tumormikroumgebung.",
      "journal": "Small (Weinheim an der Bergstrasse, Germany)",
      "authors": "Zhang et al.",
      "author_search": "zhang zhang",
      "doi": "10.1002/smll.202408809",
      "doi_url": "https://doi.org/10.1002/smll.202408809",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40259480/",
      "url": "https://h2medicine.org/studies/study-zhang-2025-rna-seq-reveals-mechanism/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "liver",
        "neurology",
        "cancer",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "40251018",
      "year": 2025,
      "title": "Dietary addition of magnesium hydride nanoparticles: a breakthrough in combating high-fat diet-induced chronic kidney disease.",
      "title_en": null,
      "title_de": "Diätetische Zugabe von Magnesiumhydrid-Nanopartikeln: ein Durchbruch bei der Bekämpfung der durch fettreiche Ernährung induzierten chronischen Nierenerkrankung.",
      "journal": "Medical gas research",
      "authors": "Lu et al.",
      "author_search": "lu lu",
      "doi": "10.4103/mgr.medgasres-d-24-00090",
      "doi_url": "https://doi.org/10.4103/mgr.medgasres-d-24-00090",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40251018/",
      "url": "https://h2medicine.org/studies/study-lu-2025-dietary-addition-magnesium-hydride/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "metabolic",
        "kidney-dialysis",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "40238879",
      "year": 2025,
      "title": "Hydrogen-induced disruption of the airway mucus barrier enhances nebulized RNA delivery to reverse pulmonary fibrosis.",
      "title_en": null,
      "title_de": "Wasserstoff-induzierte Störung der Atemwegsschleimbarriere verstärkt die vernebelte RNA-Abgabe zur Umkehrung der Lungenfibrose.",
      "journal": "Science advances",
      "authors": "Liu et al.",
      "author_search": "liu liu",
      "doi": "10.1126/sciadv.adt2752",
      "doi_url": "https://doi.org/10.1126/sciadv.adt2752",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40238879/",
      "url": "https://h2medicine.org/studies/study-liu-2025-induced-disruption-airway-mucus/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "metabolic",
        "liver",
        "respiratory"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "40189120",
      "year": 2025,
      "title": "A partially degradable composite consisting of Ti-Zr-Cu-Pd-Sn metallic glass and Fe-Mg alloy for orthopedic applications.",
      "title_en": null,
      "title_de": "Ein teilweise abbaubarer Verbundwerkstoff aus metallischem Ti-Zr-Cu-Pd-Sn-Glas und Fe-Mg-Legierung für orthopädische Anwendungen.",
      "journal": "Acta biomaterialia",
      "authors": "Du et al.",
      "author_search": "du du",
      "doi": "10.1016/j.actbio.2025.04.011",
      "doi_url": "https://doi.org/10.1016/j.actbio.2025.04.011",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40189120/",
      "url": "https://h2medicine.org/studies/study-du-2025-partially-degradable-composite-consisting/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "40077785",
      "year": 2025,
      "title": "Hydrogen and Methane Detection in Breath in Response to Two Different Types of Dietary Fiber and Its Relationship to Postprandial Glucose Concentration in Obese Patients with Type 2 Diabetes and Normoglycemic Subjects.",
      "title_en": null,
      "title_de": "Wasserstoff- und Methannachweis in der Atemluft als Reaktion auf zwei verschiedene Ballaststoffarten und dessen Zusammenhang mit der postprandialen Glukosekonzentration bei adipösen Patienten mit Typ-2-Diabetes und normoglykämischen Probanden",
      "journal": "Nutrients",
      "authors": "Misnikova et al.",
      "author_search": "misnikova misnikova",
      "doi": "10.3390/nu17050917",
      "doi_url": "https://doi.org/10.3390/nu17050917",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40077785/",
      "url": "https://h2medicine.org/studies/study-misnikova-2025-methane-detection-breath-response/",
      "methods": [],
      "indications": [
        "diabetes",
        "metabolic"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "40066473",
      "year": 2025,
      "title": "Galvanic Cell Bipolar Microneedle Patches for Reversing Photoaging Wrinkles.",
      "title_en": null,
      "title_de": "Galvanische bipolare Mikronadel-Pflaster zur Umkehrung von Photoalterungs-Falten.",
      "journal": "Advanced materials (Deerfield Beach, Fla.)",
      "authors": "Lin et al.",
      "author_search": "lin lin",
      "doi": "10.1002/adma.202500552",
      "doi_url": "https://doi.org/10.1002/adma.202500552",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40066473/",
      "url": "https://h2medicine.org/studies/study-lin-2025-galvanic-cell-bipolar-microneedle/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cancer",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "40010997",
      "year": 2025,
      "title": "Molecular Hydrogen Therapy Enhances Immune Markers in Treg, Plasma, Tr1 Cells, and KLRG1 Expression on Tc Cells: A Case of Acute SDH With Midline Shift and Uncal Herniation Post-decompressive Craniectomy.",
      "title_en": null,
      "title_de": "Therapie mit molekularem Wasserstoff verstärkt Immunmarker in Treg-, Plasma-, Tr1-Zellen und die KLRG1-Expression auf Tc-Zellen: Ein Fall von akutem Subduralhämatom mit Mittellinienverlagerung und Unkusherniation nach dekompressiver Kraniektomie",
      "journal": "In vivo (Athens, Greece)",
      "authors": "Hsu et al.",
      "author_search": "hsu hsu",
      "doi": "10.21873/invivo.13923",
      "doi_url": "https://doi.org/10.21873/invivo.13923",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40010997/",
      "url": "https://h2medicine.org/studies/study-hsu-2025-enhances-immune-markers-treg/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise",
        "neurology",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "40010970",
      "year": 2025,
      "title": "Molecular Hydrogen Therapy for SLE-PAH: Case Report on Immune Marker Modulation.",
      "title_en": null,
      "title_de": "Therapie mit molekularem Wasserstoff bei SLE-PAH: Fallbericht über die Modulation von Immunmarkern",
      "journal": "In vivo (Athens, Greece)",
      "authors": "Tu et al.",
      "author_search": "tu tu",
      "doi": "10.21873/invivo.13926",
      "doi_url": "https://doi.org/10.21873/invivo.13926",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40010970/",
      "url": "https://h2medicine.org/studies/study-tu-2025-sle-pah-immune-marker/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cardiovascular",
        "respiratory",
        "immune-system"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "40010949",
      "year": 2025,
      "title": "Molecular Hydrogen as an Adjuvant Therapy in Severe Lupus Serositis With Heart Failure: A Case Report on Immune Modulation and Fatigue Reduction.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff als adjuvante Therapie bei schwerer Lupus-Serositis mit Herzinsuffizienz: Ein Fallbericht über Immunmodulation und Reduktion der Ermüdung",
      "journal": "In vivo (Athens, Greece)",
      "authors": "Lin et al.",
      "author_search": "lin lin",
      "doi": "10.21873/invivo.13924",
      "doi_url": "https://doi.org/10.21873/invivo.13924",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40010949/",
      "url": "https://h2medicine.org/studies/study-lin-2025-adjuvant-severe-lupus-serositis/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise",
        "cardiovascular",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "39969918",
      "year": 2025,
      "title": "Performance of Unmodified Mechanical Ventilators With 2% Hydrogen Gas Mixtures.",
      "title_en": null,
      "title_de": "Leistung unmodifizierter mechanischer Beatmungsgeräte mit 2%-Wasserstoffgasgemischen.",
      "journal": "Respiratory care",
      "authors": "Mancebo et al.",
      "author_search": "mancebo mancebo",
      "doi": "10.4187/respcare.12371",
      "doi_url": "https://doi.org/10.4187/respcare.12371",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39969918/",
      "url": "https://h2medicine.org/studies/study-mancebo-2025-performance-unmodified-mechanical-ventilators/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "liver",
        "sports-exercise",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "39934143",
      "year": 2025,
      "title": "Hemodialysis employing molecular hydrogen (H2) enriched dialysis solution may improve dialysis related fatigue through impact on energy metabolism.",
      "title_en": null,
      "title_de": "Hämodialyse mit molekularem Wasserstoff (H₂)-angereicherter Dialyselösung könnte die dialysebedingte Ermüdung durch Einfluss auf den Energiestoffwechsel verbessern",
      "journal": "Scientific reports",
      "authors": "Nakayama et al.",
      "author_search": "nakayama nakayama",
      "doi": "10.1038/s41598-025-88827-2",
      "doi_url": "https://doi.org/10.1038/s41598-025-88827-2",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39934143/",
      "url": "https://h2medicine.org/studies/study-nakayama-2025-hemodialysis-employing-enriched-dialysis/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "metabolic",
        "sports-exercise",
        "kidney-dialysis"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "39921438",
      "year": 2025,
      "title": "Ternary Schottky Junction for Sonocatalytic Water Splitting in Gas-Immunotherapy-Mediated Cancer Treatment.",
      "title_en": null,
      "title_de": "Ternärer Schottky-Übergang zur sonokatalytischen Wasserspaltung in der gas-immuntherapie-vermittelten Krebsbehandlung.",
      "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
      "authors": "Zhang et al.",
      "author_search": "zhang zhang",
      "doi": "10.1002/advs.202413519",
      "doi_url": "https://doi.org/10.1002/advs.202413519",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39921438/",
      "url": "https://h2medicine.org/studies/study-zhang-2025-ternary-schottky-junction-sonocatalytic/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "39838815",
      "year": 2025,
      "title": "A Sustained H2/Fluorouracil-Releasing Suppository for High-efficacy and Low-Toxicity Hydrogenochemotherapy of Colon Cancer.",
      "title_en": null,
      "title_de": "Ein H₂/Fluorouracil-freisetzendes Suppositorium mit anhaltender Wirkung für die hocheffiziente und niedertoxische Hydrogeno-Chemotherapie von Dickdarmkrebs.",
      "journal": "Advanced healthcare materials",
      "authors": "Chen et al.",
      "author_search": "chen chen",
      "doi": "10.1002/adhm.202404054",
      "doi_url": "https://doi.org/10.1002/adhm.202404054",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39838815/",
      "url": "https://h2medicine.org/studies/study-chen-2025-sustained-fluorouracil-releasing-suppository/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "oxidative-stress",
        "fundamentals-safety"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "39804806",
      "year": 2025,
      "title": "Hydrogen-Rich Saline Combined With Vacuum Sealing Drainage Promotes Wound Healing by Altering Biotin Metabolism.",
      "title_en": null,
      "title_de": "Wasserstoffreiche Kochsalzlösung in Kombination mit Vakuumversiegelungsdrainage fördert die Wundheilung durch Veränderung des Biotin-Stoffwechsels",
      "journal": "Journal of cellular and molecular medicine",
      "authors": "Kuang et al.",
      "author_search": "kuang kuang",
      "doi": "10.1111/jcmm.70292",
      "doi_url": "https://doi.org/10.1111/jcmm.70292",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39804806/",
      "url": "https://h2medicine.org/studies/study-kuang-2025-saline-combined-vacuum-sealing/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "39791170",
      "year": 2025,
      "title": "Protective Effects of Hydrogen Treatment Against High Glucose-Induced Oxidative Stress and Apoptosis via Inhibition of the AGEs/RAGE/NF-κB Signaling Pathway in Skin Cells.",
      "title_en": null,
      "title_de": "Schützende Wirkungen der Wasserstoffbehandlung gegen durch hohe Glukose induzierten oxidativen Stress und Apoptose über die Hemmung des AGEs/RAGE/NF-κB-Signalwegs in Hautzellen.",
      "journal": "Endocrine, metabolic & immune disorders drug targets",
      "authors": "Yu et al.",
      "author_search": "yu yu",
      "doi": "10.2174/0118715303369584241231141001",
      "doi_url": "https://doi.org/10.2174/0118715303369584241231141001",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39791170/",
      "url": "https://h2medicine.org/studies/study-yu-2025-protective-against-high-glucose/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "diabetes",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "39775989",
      "year": 2025,
      "title": "Manganese Galvanic Cells Intervene in Tumor Metabolism to Reinforce cGAS-STING Activation for Bidirectional Synergistic Hydrogen-Immunotherapy.",
      "title_en": null,
      "title_de": "Mangan-Galvanikzellen greifen in den Tumorstoffwechsel ein, um die cGAS-STING-Aktivierung für eine bidirektionale synergistische Wasserstoff-Immuntherapie zu verstärken.",
      "journal": "Advanced materials (Deerfield Beach, Fla.)",
      "authors": "Yang et al.",
      "author_search": "yang yang",
      "doi": "10.1002/adma.202414929",
      "doi_url": "https://doi.org/10.1002/adma.202414929",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39775989/",
      "url": "https://h2medicine.org/studies/study-yang-2025-manganese-galvanic-cells-intervene/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "liver",
        "cardiovascular",
        "cancer",
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "39740897",
      "year": 2025,
      "title": "Molecular Hydrogen as a Potential Adjunctive Therapy to Improve Renal Function and Reduce Fatigue in an Elderly Patient With Chronic Comorbidities: A Case Report.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff als potenzielle adjunktive Therapie zur Verbesserung der Nierenfunktion und Reduktion der Ermüdung bei einem älteren Patienten mit chronischen Komorbiditäten: Ein Fallbericht",
      "journal": "In vivo (Athens, Greece)",
      "authors": "Lin et al.",
      "author_search": "lin lin",
      "doi": "10.21873/invivo.13862",
      "doi_url": "https://doi.org/10.21873/invivo.13862",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39740897/",
      "url": "https://h2medicine.org/studies/study-lin-2025-adjunctive-improve-renal-function/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "diabetes",
        "sports-exercise",
        "cardiovascular",
        "kidney-dialysis",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "39740868",
      "year": 2025,
      "title": "Precision Assessment of Anti-NMDA Receptor Encephalitis: A Case Report on Integrating Clinical Course, Immunophenotyping, and Comprehensive Symptomatology in a Pediatric Patient With Adjunctive Hydrogen Therapy.",
      "title_en": null,
      "title_de": "Präzise Bewertung der Anti-NMDA-Rezeptor-Enzephalitis: Ein Fallbericht über die Integration von klinischem Verlauf, Immunphänotypisierung und umfassender Symptomatologie bei einem pädiatrischen Patienten mit adjunktiver Wasserstofftherapie",
      "journal": "In vivo (Athens, Greece)",
      "authors": "Lin et al.",
      "author_search": "lin lin",
      "doi": "10.21873/invivo.13858",
      "doi_url": "https://doi.org/10.21873/invivo.13858",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39740868/",
      "url": "https://h2medicine.org/studies/study-lin-2025-precision-anti-nmda-receptor/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "immune-system"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "39737874",
      "year": 2025,
      "title": "Multifaceted Immunomodulatory Nanocomplexes Target Neutrophilic-ROS Inflammation in Acute Lung Injury.",
      "title_en": null,
      "title_de": "Vielseitige immunmodulatorische Nanokomplexe zielen auf neutrophile ROS-Entzündung bei akuter Lungenschädigung ab.",
      "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
      "authors": "Su et al.",
      "author_search": "su su",
      "doi": "10.1002/advs.202411823",
      "doi_url": "https://doi.org/10.1002/advs.202411823",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39737874/",
      "url": "https://h2medicine.org/studies/study-su-2025-multifaceted-immunomodulatory-nanocomplexes-target/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "respiratory",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "39726077",
      "year": 2025,
      "title": "Hydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis.",
      "title_en": null,
      "title_de": "Hydrolyse von 2D-Nanoblättern kehrt rheumatoide Arthritis durch Entzündungshemmung und Osteogenese um.",
      "journal": "Advanced materials (Deerfield Beach, Fla.)",
      "authors": "Ji et al.",
      "author_search": "ji ji",
      "doi": "10.1002/adma.202415543",
      "doi_url": "https://doi.org/10.1002/adma.202415543",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39726077/",
      "url": "https://h2medicine.org/studies/study-ji-2025-hydrolysis-nanosheets-reverses-rheumatoid/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "sports-exercise",
        "joints-rheumatology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "39656877",
      "year": 2025,
      "title": "Hydrogen-Generating Magnesium Alloy Seed Strand Sensitizes Solid Tumors to Iodine-125 Brachytherapy.",
      "title_en": null,
      "title_de": "Wasserstofferzeugender Magnesiumlegierungs-Seed-Strang sensibilisiert solide Tumoren für die Iod-125-Brachytherapie.",
      "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
      "authors": "Hu et al.",
      "author_search": "hu hu",
      "doi": "10.1002/advs.202412263",
      "doi_url": "https://doi.org/10.1002/advs.202412263",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39656877/",
      "url": "https://h2medicine.org/studies/study-hu-2025-generating-magnesium-alloy-seed/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "liver",
        "cancer",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "39495651",
      "year": 2025,
      "title": "Living Therapeutics for Synergistic Hydrogen-Photothermal Cancer Treatment by Photosynthetic Bacteria.",
      "title_en": null,
      "title_de": "Lebende Therapeutika für die synergistische photothermische Wasserstoff-Krebsbehandlung durch photosynthetische Bakterien.",
      "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
      "authors": "Zhang et al.",
      "author_search": "zhang zhang",
      "doi": "10.1002/advs.202408807",
      "doi_url": "https://doi.org/10.1002/advs.202408807",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39495651/",
      "url": "https://h2medicine.org/studies/study-zhang-2025-living-therapeutics-synergistic-photothermal/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cancer",
        "fundamentals-safety"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "39426122",
      "year": 2025,
      "title": "Engineering probiotic biohydrogen micro-factories to initiate reductive stress for boosting tumor vulnerability.",
      "title_en": null,
      "title_de": "Entwicklung probiotischer Biowasserstoff-Mikrofabriken zur Auslösung von reduktivem Stress zur Verstärkung der Tumorvulnerabilität.",
      "journal": "Biomaterials",
      "authors": "Jiang et al.",
      "author_search": "jiang jiang",
      "doi": "10.1016/j.biomaterials.2024.122892",
      "doi_url": "https://doi.org/10.1016/j.biomaterials.2024.122892",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39426122/",
      "url": "https://h2medicine.org/studies/study-jiang-2025-engineering-probiotic-biohydrogen-micro/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver",
        "cancer",
        "respiratory",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "39190941",
      "year": 2025,
      "title": "Mitochondrial 'Birth-Death' coordinator: An intelligent hydrogen nanogenerator to enhance intervertebral disc regeneration.",
      "title_en": null,
      "title_de": "Mitochondrialer ‚Geburt-Tod'-Koordinator: Ein intelligenter Wasserstoff-Nanogenerator zur Verstärkung der Bandscheibenregeneration",
      "journal": "Biomaterials",
      "authors": "Ji et al.",
      "author_search": "ji ji",
      "doi": "10.1016/j.biomaterials.2024.122764",
      "doi_url": "https://doi.org/10.1016/j.biomaterials.2024.122764",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39190941/",
      "url": "https://h2medicine.org/studies/study-ji-2025-mitochondrial-birth-death-coordinator/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "38634423",
      "year": 2025,
      "title": "Effect of hydrogen-rich saline on melanopsin after acute blue light-induced retinal damage in rats",
      "title_en": null,
      "title_de": "Wirkung von wasserstoffreicher Kochsalzlösung auf Melanopsin nach akutem blaulichtinduziertem Netzhautschaden bei Ratten",
      "journal": "Photochemistry and Photobiology",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1111/php.13952",
      "doi_url": "https://doi.org/10.1111/php.13952",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38634423/",
      "url": "https://h2medicine.org/studies/study-wang-2025-hydrogen-rich-saline-melanopsin-blue-light-retina/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "eye",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "40411985",
      "year": 2025,
      "title": "Hydrogen activates ACOD1-itaconate pathway to ameliorate steroid-associated osteonecrosis",
      "title_en": null,
      "title_de": "Wasserstoff aktiviert den ACOD1-Itaconat-Signalweg zur Linderung steroidassoziierter Osteonekrose",
      "journal": "Biomaterials",
      "authors": "An et al.",
      "author_search": "an an",
      "doi": "10.1016/j.biomaterials.2025.123428",
      "doi_url": "https://doi.org/10.1016/j.biomaterials.2025.123428",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40411985/",
      "url": "https://h2medicine.org/studies/study-an-2025-acod1-itaconate-steroid-osteonecrosis/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "joints-rheumatology",
        "oxidative-stress",
        "fundamentals"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "40705191",
      "year": 2025,
      "title": "Molecular hydrogen attenuates cisplatin-induced nephrotoxicity by modulating β-hydroxybutyrate metabolism",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff mildert die durch Cisplatin ausgelöste Nierentoxizität durch Modulation des β-Hydroxybutyrat-Stoffwechsels",
      "journal": "Molecular Biology Reports",
      "authors": "Tian et al.",
      "author_search": "tian tian",
      "doi": "10.1007/s11033-025-10845-0",
      "doi_url": "https://doi.org/10.1007/s11033-025-10845-0",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40705191/",
      "url": "https://h2medicine.org/studies/study-tian-2025-cisplatin-nephrotoxicity-beta-hydroxybutyrate/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "kidney-dialysis",
        "cancer",
        "oxidative-stress",
        "metabolic"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "38256045",
      "year": 2024,
      "title": "Hydrogen Water: Extra Healthy or a Hoax?-A Systematic Review",
      "title_en": null,
      "title_de": "Wasserstoffwasser: extra gesund oder Schwindel? — Eine systematische Übersicht",
      "journal": "International Journal of Molecular Sciences",
      "authors": "Dhillon et al.",
      "author_search": "dhillon dhillon",
      "doi": "10.3390/ijms25020973",
      "doi_url": "https://doi.org/10.3390/ijms25020973",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38256045/",
      "url": "https://h2medicine.org/studies/study-dhillon-2024-hydrogen-water-hoax-systematic-review/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "fundamentals",
        "oxidative-stress",
        "sports-exercise",
        "liver",
        "cardiovascular",
        "neurology",
        "respiratory",
        "skin-aging"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "39808170",
      "year": 2024,
      "title": "New possibilities of the prevention and treatment of cardiovascular pathologies. the potential of molecular hydrogen in the reduction of oxidative stress and its consequences.",
      "title_en": null,
      "title_de": "Neue Möglichkeiten der Prävention und Behandlung kardiovaskulärer Pathologien: Das Potenzial von molekularem Wasserstoff bei der Reduzierung von oxidativem Stress",
      "journal": "Physiological research",
      "authors": "Slezák et al.",
      "author_search": "slezák slezák",
      "doi": "10.33549/physiolres.935491",
      "doi_url": "https://doi.org/10.33549/physiolres.935491",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39808170/",
      "url": "https://h2medicine.org/studies/study-slezak-2024-possibilities-prevention-cardiovascular-pathologies/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "metabolic",
        "sports-exercise",
        "neurology",
        "cardiovascular",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "39487838",
      "year": 2024,
      "title": "Perspective targeted diagnosis and therapy of mitochondrial bioenergetics across different diagnoses.",
      "title_en": null,
      "title_de": "Perspektivische gezielte Diagnose und Therapie der mitochondrialen Bioenergetik bei verschiedenen Diagnosen",
      "journal": "Bratislavske lekarske listy",
      "authors": "Glevicka et al.",
      "author_search": "glevicka glevicka",
      "doi": "10.4149/bll_2024_105",
      "doi_url": "https://doi.org/10.4149/bll_2024_105",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39487838/",
      "url": "https://h2medicine.org/studies/study-glevicka-2024-perspective-targeted-diagnosis-mitochondrial/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "39166484",
      "year": 2024,
      "title": "The Landscape of Smart Biomaterial-Based Hydrogen Therapy.",
      "title_en": null,
      "title_de": "Die Landschaft der auf intelligenten Biomaterialien basierenden Wasserstofftherapie",
      "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
      "authors": "Xu et al.",
      "author_search": "xu xu",
      "doi": "10.1002/advs.202401310",
      "doi_url": "https://doi.org/10.1002/advs.202401310",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39166484/",
      "url": "https://h2medicine.org/studies/study-xu-2024-landscape-smart-biomaterial/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "metabolic",
        "liver",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "39111696",
      "year": 2024,
      "title": "Evolution of therapeutic strategy based on oxidant-antioxidant balance for fuchs endothelial corneal dystrophy.",
      "title_en": null,
      "title_de": "Entwicklung therapeutischer Strategien auf Basis des Oxidantien-Antioxidantien-Gleichgewichts bei der Fuchs-Endotheldystrophie der Hornhaut",
      "journal": "The ocular surface",
      "authors": "Wu et al.",
      "author_search": "wu wu",
      "doi": "10.1016/j.jtos.2024.08.003",
      "doi_url": "https://doi.org/10.1016/j.jtos.2024.08.003",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39111696/",
      "url": "https://h2medicine.org/studies/study-wu-2024-evolution-therapeutic-strategy-oxidant/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cardiovascular",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "39063126",
      "year": 2024,
      "title": "The Protective Role of Molecular Hydrogen in Ischemia/Reperfusion Injury.",
      "title_en": null,
      "title_de": "Die schützende Rolle von molekularem Wasserstoff bei Ischämie-/Reperfusionsschäden",
      "journal": "International journal of molecular sciences",
      "authors": "Kura et al.",
      "author_search": "kura kura",
      "doi": "10.3390/ijms25147884",
      "doi_url": "https://doi.org/10.3390/ijms25147884",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39063126/",
      "url": "https://h2medicine.org/studies/study-kura-2024-protective-ischemia-reperfusion-injury/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "neurology",
        "cardiovascular",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "38850720",
      "year": 2024,
      "title": "Idiopathic sudden sensorineural hearing loss: A review focused on the contribution of vascular pathologies.",
      "title_en": null,
      "title_de": "Idiopathischer plötzlicher sensorineuraler Hörverlust: Eine Übersichtsarbeit mit Fokus auf den Beitrag vaskulärer Pathologien",
      "journal": "Auris, nasus, larynx",
      "authors": "Tsuzuki et al.",
      "author_search": "tsuzuki tsuzuki",
      "doi": "10.1016/j.anl.2024.05.009",
      "doi_url": "https://doi.org/10.1016/j.anl.2024.05.009",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38850720/",
      "url": "https://h2medicine.org/studies/study-tsuzuki-2024-idiopathic-sudden-sensorineural-hearing/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "diabetes",
        "metabolic",
        "neurology",
        "cardiovascular"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "38795643",
      "year": 2024,
      "title": "Potential role of molecular hydrogen therapy on oxidative stress and redox signaling in chronic kidney disease.",
      "title_en": null,
      "title_de": "Potenzielle Rolle der Therapie mit molekularem Wasserstoff bei oxidativem Stress und Redox-Signalübertragung bei chronischer Nierenerkrankung",
      "journal": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie",
      "authors": "Zheng et al.",
      "author_search": "zheng zheng",
      "doi": "10.1016/j.biopha.2024.116802",
      "doi_url": "https://doi.org/10.1016/j.biopha.2024.116802",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38795643/",
      "url": "https://h2medicine.org/studies/study-zheng-2024-oxidative-stress-redox-signaling/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "kidney-dialysis",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "38707612",
      "year": 2024,
      "title": "The Molecular Biological Mechanism of Hydrogen Therapy and Its Application in Spinal Cord Injury.",
      "title_en": null,
      "title_de": "Der molekularbiologische Mechanismus der Wasserstofftherapie und ihre Anwendung bei Rückenmarksverletzungen",
      "journal": "Drug design, development and therapy",
      "authors": "Hu et al.",
      "author_search": "hu hu",
      "doi": "10.2147/dddt.s463177",
      "doi_url": "https://doi.org/10.2147/dddt.s463177",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38707612/",
      "url": "https://h2medicine.org/studies/study-hu-2024-biological-mechanism-application-spinal/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "38661046",
      "year": 2024,
      "title": "Exploring approaches to pulp vitality assessment: A scoping review of nontraditional methods.",
      "title_en": null,
      "title_de": "Untersuchung von Ansätzen zur Beurteilung der Pulpavitalität: Ein Scoping Review nichttraditioneller Methoden",
      "journal": "International endodontic journal",
      "authors": "Afkhami et al.",
      "author_search": "afkhami afkhami",
      "doi": "10.1111/iej.14073",
      "doi_url": "https://doi.org/10.1111/iej.14073",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38661046/",
      "url": "https://h2medicine.org/studies/study-afkhami-2024-exploring-approaches-pulp-vitality/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "skin-aging",
        "oral-health"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "38638053",
      "year": 2024,
      "title": "The Therapeutic Application of Hydrogen in Cancer: The Potential and Challenges.",
      "title_en": null,
      "title_de": "Die therapeutische Anwendung von Wasserstoff bei Krebs: Das Potenzial und die Herausforderungen",
      "journal": "Current pharmaceutical design",
      "authors": "Khiji et al.",
      "author_search": "khiji khiji",
      "doi": "10.2174/0113816128296710240404040232",
      "doi_url": "https://doi.org/10.2174/0113816128296710240404040232",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38638053/",
      "url": "https://h2medicine.org/studies/study-khiji-2024-therapeutic-application-cancer-challenges/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "immune-system",
        "oxidative-stress",
        "fundamentals-safety"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "38615891",
      "year": 2024,
      "title": "The role of hydrogen in the prevention and treatment of coronary atherosclerotic heart disease.",
      "title_en": null,
      "title_de": "Die Rolle von Wasserstoff bei der Prävention und Behandlung der koronaren atherosklerotischen Herzkrankheit",
      "journal": "European journal of pharmacology",
      "authors": "Chen et al.",
      "author_search": "chen chen",
      "doi": "10.1016/j.ejphar.2024.176586",
      "doi_url": "https://doi.org/10.1016/j.ejphar.2024.176586",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38615891/",
      "url": "https://h2medicine.org/studies/study-chen-2024-prevention-coronary-atherosclerotic-heart/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "metabolic",
        "cardiovascular",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "38377746",
      "year": 2024,
      "title": "Catalytic innovations: Improving wastewater treatment and hydrogen generation technologies.",
      "title_en": null,
      "title_de": "Katalytische Innovationen: Verbesserung von Abwasserbehandlungs- und Wasserstofferzeugungstechnologien.",
      "journal": "Journal of environmental management",
      "authors": "Khan et al.",
      "author_search": "khan khan",
      "doi": "10.1016/j.jenvman.2024.120228",
      "doi_url": "https://doi.org/10.1016/j.jenvman.2024.120228",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38377746/",
      "url": "https://h2medicine.org/studies/study-khan-2024-catalytic-innovations-improving-wastewater/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "38532373",
      "year": 2024,
      "title": "The effect of hydrogen-rich water consumption on premenstrual symptoms and quality of life: a randomized controlled trial",
      "title_en": null,
      "title_de": "Die Wirkung des Konsums von wasserstoffreichem Wasser auf prämenstruelle Symptome und Lebensqualität: eine randomisierte kontrollierte Studie",
      "journal": "BMC Women's Health",
      "authors": "Aker et al.",
      "author_search": "aker aker",
      "doi": "10.1186/s12905-024-03029-8",
      "doi_url": "https://doi.org/10.1186/s12905-024-03029-8",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38532373/",
      "url": "https://h2medicine.org/studies/study-aker-2024-premenstrual-symptoms-quality-of-life/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "womens-health",
        "oxidative-stress"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "38996821",
      "year": 2024,
      "title": "The impact of hydrogen inhalation therapy on blood reactive oxygen species levels: A randomized controlled study",
      "title_en": null,
      "title_de": "Der Einfluss einer Wasserstoff-Inhalationstherapie auf den Spiegel reaktiver Sauerstoffspezies im Blut: eine randomisierte kontrollierte Studie",
      "journal": "Free Radical Biology & Medicine",
      "authors": "Chair et al.",
      "author_search": "chair chair",
      "doi": "10.1016/j.freeradbiomed.2024.07.010",
      "doi_url": "https://doi.org/10.1016/j.freeradbiomed.2024.07.010",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38996821/",
      "url": "https://h2medicine.org/studies/study-chair-2024-inhalation-reactive-oxygen-species/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "oxidative-stress",
        "fundamentals"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "39703911",
      "year": 2024,
      "title": "Hydrogen gas inhalation prior to high-intensity training reduces attenuation of nitric oxide bioavailability in male rugby players",
      "title_en": null,
      "title_de": "Das Einatmen von Wasserstoffgas vor intensivem Training reduziert die Abnahme der Stickstoffmonoxid-Verfügbarkeit bei männlichen Rugby-Spielern",
      "journal": "PeerJ",
      "authors": "Zhao et al.",
      "author_search": "zhao zhao",
      "doi": "10.7717/peerj.18503",
      "doi_url": "https://doi.org/10.7717/peerj.18503",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39703911/",
      "url": "https://h2medicine.org/studies/study-zhao-2024-gas-inhalation-nitric-oxide-rugby-players/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "oxidative-stress",
        "cardiovascular"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "39064785",
      "year": 2024,
      "title": "Hydrogen-Rich Gas Enhanced Sprint-Interval Performance: Metabolomic Insights into Underlying Mechanisms.",
      "title_en": null,
      "title_de": "Wasserstoffreiches Gas verbessert die Sprint-Intervall-Leistung: Metabolomische Einblicke in die zugrunde liegenden Mechanismen",
      "journal": "Nutrients",
      "authors": "Dong et al.",
      "author_search": "dong dong",
      "doi": "10.3390/nu16142341",
      "doi_url": "https://doi.org/10.3390/nu16142341",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39064785/",
      "url": "https://h2medicine.org/studies/study-dong-2024-enhanced-sprint-interval-performance/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "metabolic",
        "sports-exercise"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "38698624",
      "year": 2024,
      "title": "Inhalation of Hydrogen-rich Gas before Acute Exercise Alleviates Exercise Fatigue: A Randomized Crossover Study.",
      "title_en": null,
      "title_de": "Inhalation von wasserstoffreichem Gas vor akuter Belastung lindert die Belastungsermüdung: Eine randomisierte Crossover-Studie",
      "journal": "International journal of sports medicine",
      "authors": "Dong et al.",
      "author_search": "dong dong",
      "doi": "10.1055/a-2318-1880",
      "doi_url": "https://doi.org/10.1055/a-2318-1880",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38698624/",
      "url": "https://h2medicine.org/studies/study-dong-2024-inhalation-before-acute-exercise/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "sports-exercise",
        "oxidative-stress"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "38232698",
      "year": 2024,
      "title": "Early time-restricted eating improves markers of cardiometabolic health but has no impact on intestinal nutrient absorption in healthy adults.",
      "title_en": null,
      "title_de": "Frühes zeitlich begrenztes Essen verbessert Marker der kardiometabolischen Gesundheit, hat aber keinen Einfluss auf die intestinale Nährstoffaufnahme bei gesunden Erwachsenen.",
      "journal": "Cell reports. Medicine",
      "authors": "Dawson et al.",
      "author_search": "dawson dawson",
      "doi": "10.1016/j.xcrm.2023.101363",
      "doi_url": "https://doi.org/10.1016/j.xcrm.2023.101363",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38232698/",
      "url": "https://h2medicine.org/studies/study-dawson-2024-early-time-restricted-eating/",
      "methods": [],
      "indications": [
        "diabetes",
        "cardiovascular"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "38713041",
      "year": 2024,
      "title": "[Rehabilitation program of post-COVID-19 syndrome with the use of nitric oxide and molecular hydrogen].",
      "title_en": null,
      "title_de": "Rehabilitationsprogramm des Post-COVID-19-Syndroms unter Einsatz von Stickstoffmonoxid und molekularem Wasserstoff",
      "journal": "Terapevticheskii Arkhiv",
      "authors": "Pozdnyakova et al.",
      "author_search": "pozdnyakova pozdnyakova",
      "doi": "10.26442/00403660.2024.03.202639",
      "doi_url": "https://doi.org/10.26442/00403660.2024.03.202639",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38713041/",
      "url": "https://h2medicine.org/studies/study-pozdnyakova-2024-nitric-oxide-post-covid-19-rehabilitation/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "respiratory",
        "oxidative-stress",
        "cardiovascular"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "38794767",
      "year": 2024,
      "title": "The Effect of 14-Day Consumption of Hydrogen-Rich Water Alleviates Fatigue but Does Not Ameliorate Dyspnea in Long-COVID Patients: A Pilot, Single-Blind, and Randomized, Controlled Trial",
      "title_en": null,
      "title_de": "Der 14-tägige Konsum von wasserstoffreichem Wasser lindert Müdigkeit, bessert jedoch nicht die Atemnot bei Long-COVID-Patienten: eine einfach-verblindete, randomisierte, kontrollierte Pilotstudie",
      "journal": "Nutrients",
      "authors": "Tan et al.",
      "author_search": "tan tan",
      "doi": "10.3390/nu16101529",
      "doi_url": "https://doi.org/10.3390/nu16101529",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38794767/",
      "url": "https://h2medicine.org/studies/study-tan-2024-long-covid-fatigue-dyspnea/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "respiratory",
        "immune-system",
        "sports-exercise"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "39016593",
      "year": 2024,
      "title": "H2 inhalation therapy in patients with moderate COVID-19 (H2COVID): a prospective ascending-dose phase I clinical trial.",
      "title_en": null,
      "title_de": "H2-Inhalationstherapie bei Patienten mit moderatem COVID-19 (H2COVID): eine prospektive Phase-I-Studie mit ansteigender Dosis",
      "journal": "Antimicrobial Agents and Chemotherapy",
      "authors": "Salomez-Ihl et al.",
      "author_search": "salomez-ihl salomez-ihl",
      "doi": "10.1128/aac.00573-24",
      "doi_url": "https://doi.org/10.1128/aac.00573-24",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39016593/",
      "url": "https://h2medicine.org/studies/study-salomez-ihl-2024-h2covid-phase-i-moderate-covid-19/",
      "methods": [
        "inhalation",
        "bath-topical"
      ],
      "indications": [
        "respiratory",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "39133068",
      "year": 2024,
      "title": "Combination of Hydrogen Inhalation and Hypothermic Temperature Control After Out-of-Hospital Cardiac Arrest: A Post hoc Analysis of the Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During PostCardiac Arrest Care II Trial",
      "title_en": null,
      "title_de": "Kombination aus Wasserstoff-Inhalation und hypothermer Temperaturkontrolle nach außerklinischem Herzstillstand: eine Post-hoc-Analyse der HYBRID-II-Studie zur Wirksamkeit inhalierten Wasserstoffs auf das neurologische Ergebnis nach zerebraler Ischämie",
      "journal": "Critical Care Medicine",
      "authors": "Tamura et al.",
      "author_search": "tamura tamura",
      "doi": "10.1097/ccm.0000000000006395",
      "doi_url": "https://doi.org/10.1097/ccm.0000000000006395",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39133068/",
      "url": "https://h2medicine.org/studies/study-tamura-2024-cardiac-arrest-hypothermic-neurologic-outcome/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "neurology",
        "cardiovascular"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "39310256",
      "year": 2024,
      "title": "Using oral molecular hydrogen supplements to combat microinflammation in humans: a pilot observational study.",
      "title_en": null,
      "title_de": "Einsatz oraler molekularer Wasserstoff-Präparate zur Bekämpfung von Mikroinflammation beim Menschen: eine Pilot-Beobachtungsstudie",
      "journal": "International Journal of Medical Sciences",
      "authors": "Lu et al.",
      "author_search": "lu lu",
      "doi": "10.7150/ijms.101114",
      "doi_url": "https://doi.org/10.7150/ijms.101114",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39310256/",
      "url": "https://h2medicine.org/studies/study-lu-2024-oral-supplements-microinflammation/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "immune-system",
        "oxidative-stress",
        "metabolic"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "39477420",
      "year": 2024,
      "title": "Molecular Hydrogen Therapy in Aneurysmal SAH With RA and Newly-diagnosed SLE, Complicated With Acute Ischemic Infarction: A Case Report of Improved Immune Markers Including Tr1 Cells, Breg Cells and TIM3 Expression on Tc Cells.",
      "title_en": null,
      "title_de": "Molekulare Wasserstofftherapie bei aneurysmatischer SAB mit RA und neu diagnostiziertem SLE, kompliziert durch akuten ischämischen Infarkt: Ein Fallbericht über verbesserte Immunmarker einschließlich Tr1-Zellen, Breg-Zellen und TIM3-Expression auf Tc-Zellen.",
      "journal": "In vivo (Athens, Greece)",
      "authors": "Chen et al.",
      "author_search": "chen chen",
      "doi": "10.21873/invivo.13799",
      "doi_url": "https://doi.org/10.21873/invivo.13799",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39477420/",
      "url": "https://h2medicine.org/studies/study-chen-2024-aneurysmal-sah-newly-diagnosed/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "neurology",
        "skin-aging",
        "joints-rheumatology",
        "immune-system"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "39477378",
      "year": 2024,
      "title": "Molecular Hydrogen Therapy in Sjögren's Syndrome With Pulmonary Arterial Hypertension and Right-sided Heart Failure: A Case Report of Improved Immune Markers Including Treg, B Cells and Plasma Cell.",
      "title_en": null,
      "title_de": "Molekulare Wasserstofftherapie beim Sjögren-Syndrom mit pulmonaler arterieller Hypertonie und Rechtsherzinsuffizienz: Ein Fallbericht über verbesserte Immunmarker einschließlich Treg, B-Zellen und Plasmazellen.",
      "journal": "In vivo (Athens, Greece)",
      "authors": "Lin et al.",
      "author_search": "lin lin",
      "doi": "10.21873/invivo.13797",
      "doi_url": "https://doi.org/10.21873/invivo.13797",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39477378/",
      "url": "https://h2medicine.org/studies/study-lin-2024-sjoegren-syndrome-pulmonary-arterial/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cardiovascular",
        "respiratory",
        "skin-aging",
        "immune-system"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "39400361",
      "year": 2024,
      "title": "Modulating the Electronic Structure of MnNi2S3 Nanoelectrodes to Activate Pyroptosis for Electrocatalytic Hydrogen-Immunotherapy.",
      "title_en": null,
      "title_de": "Modulation der elektronischen Struktur von MnNi₂S₃-Nanoelektroden zur Aktivierung der Pyroptose für die elektrokatalytische Wasserstoff-Immuntherapie.",
      "journal": "Advanced materials (Deerfield Beach, Fla.)",
      "authors": "Li et al.",
      "author_search": "li li",
      "doi": "10.1002/adma.202412925",
      "doi_url": "https://doi.org/10.1002/adma.202412925",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39400361/",
      "url": "https://h2medicine.org/studies/study-li-2024-modulating-electronic-structure-mnni2s3/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver",
        "cancer",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "39271809",
      "year": 2024,
      "title": "The effect of hydrogen gas on the oxidative stress response in adipose tissue.",
      "title_en": null,
      "title_de": "Die Wirkung von Wasserstoffgas auf die Reaktion auf oxidativen Stress im Fettgewebe.",
      "journal": "Scientific reports",
      "authors": "Tumurbaatar et al.",
      "author_search": "tumurbaatar tumurbaatar",
      "doi": "10.1038/s41598-024-72626-2",
      "doi_url": "https://doi.org/10.1038/s41598-024-72626-2",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39271809/",
      "url": "https://h2medicine.org/studies/study-tumurbaatar-2024-oxidative-stress-response-adipose/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "metabolic",
        "cardiovascular",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "39216558",
      "year": 2024,
      "title": "Hydrogen regulated pyroptosis through NLRP3-GSDMD pathway to improve airway mucosal oxidative stress injury induced by endotracheal tube cuff compression.",
      "title_en": null,
      "title_de": "Wasserstoff reguliert die Pyroptose über den NLRP3-GSDMD-Signalweg zur Verbesserung der durch Endotrachealtubus-Cuff-Kompression induzierten oxidativen Stressschädigung der Atemwegsschleimhaut.",
      "journal": "Free radical biology & medicine",
      "authors": "Mu et al.",
      "author_search": "mu mu",
      "doi": "10.1016/j.freeradbiomed.2024.08.035",
      "doi_url": "https://doi.org/10.1016/j.freeradbiomed.2024.08.035",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39216558/",
      "url": "https://h2medicine.org/studies/study-mu-2024-regulated-pyroptosis-through-nlrp3/",
      "methods": [
        "inhalation",
        "saline-iv"
      ],
      "indications": [
        "respiratory",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "39173802",
      "year": 2024,
      "title": "Multifaceted exploration of acylthiourea compounds: In vitro cytotoxicity, DFT calculations, molecular docking and dynamics simulation studies.",
      "title_en": null,
      "title_de": "Vielschichtige Untersuchung von Acylthioharnstoff-Verbindungen: In-vitro-Zytotoxizität, DFT-Berechnungen, molekulares Docking und Dynamiksimulationsstudien.",
      "journal": "International journal of biological macromolecules",
      "authors": "Haribabu et al.",
      "author_search": "haribabu haribabu",
      "doi": "10.1016/j.ijbiomac.2024.134870",
      "doi_url": "https://doi.org/10.1016/j.ijbiomac.2024.134870",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39173802/",
      "url": "https://h2medicine.org/studies/study-haribabu-2024-multifaceted-exploration-acylthiourea-compounds/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "respiratory"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "39147072",
      "year": 2024,
      "title": "Hydrogen-rich water alleviates asthma airway inflammation by modulating tryptophan metabolism and activating aryl hydrocarbon receptor via gut microbiota regulation.",
      "title_en": null,
      "title_de": "Wasserstoffreiches Wasser lindert die Atemwegsentzündung bei Asthma durch Modulation des Tryptophan-Stoffwechsels und Aktivierung des Aryl-Hydrocarbon-Rezeptors über die Regulation der Darmmikrobiota.",
      "journal": "Free radical biology & medicine",
      "authors": "Li et al.",
      "author_search": "li li",
      "doi": "10.1016/j.freeradbiomed.2024.08.009",
      "doi_url": "https://doi.org/10.1016/j.freeradbiomed.2024.08.009",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39147072/",
      "url": "https://h2medicine.org/studies/study-li-2024-alleviates-asthma-airway-inflammation/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "respiratory",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "39116782",
      "year": 2024,
      "title": "A novel intervention of molecular hydrogen on the unbalance of the gut microbiome in opioid addiction: Experimental and human studies.",
      "title_en": null,
      "title_de": "Eine neuartige Intervention mit molekularem Wasserstoff bei der Dysbalance des Darmmikrobioms bei Opioidabhängigkeit: Experimentelle und Humanstudien.",
      "journal": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie",
      "authors": "Xie et al.",
      "author_search": "xie xie",
      "doi": "10.1016/j.biopha.2024.117273",
      "doi_url": "https://doi.org/10.1016/j.biopha.2024.117273",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39116782/",
      "url": "https://h2medicine.org/studies/study-xie-2024-intervention-unbalance-gut-microbiome/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "metabolic",
        "neurology"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "39073335",
      "year": 2024,
      "title": "Realizing brain therapy with \"smart medicine\": mechanism and case report of molecular hydrogen inhalation for Parkinson's disease.",
      "title_en": null,
      "title_de": "Hirntherapie mit „intelligenter Medizin“ verwirklichen: Mechanismus und Fallbericht zur Inhalation von molekularem Wasserstoff bei Parkinson-Krankheit.",
      "journal": "Medical gas research",
      "authors": "Ichikawa et al.",
      "author_search": "ichikawa ichikawa",
      "doi": "10.4103/2045-9912.385949",
      "doi_url": "https://doi.org/10.4103/2045-9912.385949",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39073335/",
      "url": "https://h2medicine.org/studies/study-ichikawa-2024-realizing-brain-smart-medicine/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "neurology"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "38945250",
      "year": 2024,
      "title": "d-aspartate, an amino-acid important for human health, supports anaerobic respiration in several Campylobacter species.",
      "title_en": null,
      "title_de": "d-Aspartat, eine für die menschliche Gesundheit wichtige Aminosäure, unterstützt die anaerobe Atmung bei mehreren Campylobacter-Arten.",
      "journal": "Research in microbiology",
      "authors": "Benoit et al.",
      "author_search": "benoit benoit",
      "doi": "10.1016/j.resmic.2024.104219",
      "doi_url": "https://doi.org/10.1016/j.resmic.2024.104219",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38945250/",
      "url": "https://h2medicine.org/studies/study-benoit-2024-aspartate-amino-acid-important/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise",
        "neurology"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "38934271",
      "year": 2024,
      "title": "Poly(ionic liquid)-Flocculated Chlorella Loading Bactericidal and Antioxidant Hydrogel as a Biological Hydrogen Therapy for Diabetic Wound Dressing.",
      "title_en": null,
      "title_de": "Poly(ionische Flüssigkeit)-geflocktes Chlorella mit bakteriziden und antioxidativen Hydrogel als biologische Wasserstofftherapie für diabetische Wundauflagen.",
      "journal": "ACS applied materials & interfaces",
      "authors": "Xu et al.",
      "author_search": "xu xu",
      "doi": "10.1021/acsami.4c07104",
      "doi_url": "https://doi.org/10.1021/acsami.4c07104",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38934271/",
      "url": "https://h2medicine.org/studies/study-xu-2024-poly-ionic-liquid-flocculated/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "diabetes",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "38895823",
      "year": 2024,
      "title": "Hydrogen-treated CoCrMo alloy: a novel approach to enhance biocompatibility and mitigate inflammation in orthopedic implants.",
      "title_en": null,
      "title_de": "Mit Wasserstoff behandelte CoCrMo-Legierung: Ein neuartiger Ansatz zur Verbesserung der Biokompatibilität und Abschwächung von Entzündungen bei orthopädischen Implantaten.",
      "journal": "Journal of materials chemistry. B",
      "authors": "Lin et al.",
      "author_search": "lin lin",
      "doi": "10.1039/d4tb00725e",
      "doi_url": "https://doi.org/10.1039/d4tb00725e",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38895823/",
      "url": "https://h2medicine.org/studies/study-lin-2024-treated-cocrmo-alloy-approach/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "joints-rheumatology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "38863026",
      "year": 2024,
      "title": "Early Hydrogen-Oxygen Gas Mixture Inhalation in Patients with Aneurysmal Subarachnoid Hemorrhage (HOMA): study protocol for a randomized controlled trial.",
      "title_en": null,
      "title_de": "Frühe Inhalation eines Wasserstoff-Sauerstoff-Gasgemischs bei Patienten mit aneurysmatischer Subarachnoidalblutung (HOMA): Studienprotokoll für eine randomisierte kontrollierte Studie.",
      "journal": "Trials",
      "authors": "Lin et al.",
      "author_search": "lin lin",
      "doi": "10.1186/s13063-024-08231-5",
      "doi_url": "https://doi.org/10.1186/s13063-024-08231-5",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38863026/",
      "url": "https://h2medicine.org/studies/study-lin-2024-early-oxygen-mixture-inhalation/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "neurology",
        "skin-aging",
        "fundamentals-safety"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "38855154",
      "year": 2024,
      "title": "Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway.",
      "title_en": null,
      "title_de": "Wasserstoffreiches Wasser lindert Verstopfung durch Abschwächung des oxidativen Stresses über den Sirtuin1/Nuclear-Factor-Erythroid-2-related-Factor-2/Häm-Oxygenase-1-Signalweg.",
      "journal": "World journal of gastroenterology",
      "authors": "Chen et al.",
      "author_search": "chen chen",
      "doi": "10.3748/wjg.v30.i20.2709",
      "doi_url": "https://doi.org/10.3748/wjg.v30.i20.2709",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38855154/",
      "url": "https://h2medicine.org/studies/study-chen-2024-alleviates-constipation-attenuating-oxidative/",
      "methods": [
        "saline-iv",
        "drinking-hrw"
      ],
      "indications": [
        "neurology",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "38795705",
      "year": 2024,
      "title": "Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas.",
      "title_en": null,
      "title_de": "Darmbakterien wandeln Glucocorticoide in Gegenwart von Wasserstoffgas in Gestagene um.",
      "journal": "Cell",
      "authors": "McCurry et al.",
      "author_search": "mccurry mc curry",
      "doi": "10.1016/j.cell.2024.05.005",
      "doi_url": "https://doi.org/10.1016/j.cell.2024.05.005",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38795705/",
      "url": "https://h2medicine.org/studies/study-mccurry-2024-gut-bacteria-convert-glucocorticoids/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "neurology",
        "pregnancy"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "38757665",
      "year": 2024,
      "title": "Hydrogen Therapy Reverses Cancer-Associated Fibroblasts Phenotypes and Remodels Stromal Microenvironment to Stimulate Systematic Anti-Tumor Immunity.",
      "title_en": null,
      "title_de": "Die Wasserstofftherapie kehrt die Phänotypen krebsassoziierter Fibroblasten um und remodelliert die Stroma-Mikroumgebung, um eine systemische Antitumor-Immunität zu stimulieren.",
      "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
      "authors": "Meng et al.",
      "author_search": "meng meng",
      "doi": "10.1002/advs.202401269",
      "doi_url": "https://doi.org/10.1002/advs.202401269",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38757665/",
      "url": "https://h2medicine.org/studies/study-meng-2024-reverses-cancer-associated-fibroblasts/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "38688598",
      "year": 2024,
      "title": "Molecular Hydrogen as a Promising Therapy Could Be Linked With Increased Resting Treg Cells or Decreased Fas+ T Cell Subsets in a IgG4-PF-ILD Patient: A Case Report.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff als vielversprechende Therapie könnte mit erhöhten ruhenden Treg-Zellen oder verminderten Fas+-T-Zell-Subpopulationen bei einem IgG4-PF-ILD-Patienten zusammenhängen: Ein Fallbericht.",
      "journal": "In vivo (Athens, Greece)",
      "authors": "Lui et al.",
      "author_search": "lui lui",
      "doi": "10.21873/invivo.13600",
      "doi_url": "https://doi.org/10.21873/invivo.13600",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38688598/",
      "url": "https://h2medicine.org/studies/study-lui-2024-promising-could-linked-increased/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "respiratory",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "38679666",
      "year": 2024,
      "title": "Combined use of hydrogen-rich water and enzyme-digested edible bird's nest improves PMA/LPS-impaired wound healing in human inflammatory gingival tissue equivalents.",
      "title_en": null,
      "title_de": "Die kombinierte Anwendung von wasserstoffreichem Wasser und enzymatisch verdautem essbarem Vogelnest verbessert die durch PMA/LPS beeinträchtigte Wundheilung in humanen entzündlichen Zahnfleischgewebe-Äquivalenten.",
      "journal": "Human cell",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1007/s13577-024-01065-y",
      "doi_url": "https://doi.org/10.1007/s13577-024-01065-y",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38679666/",
      "url": "https://h2medicine.org/studies/study-wang-2024-combined-use-enzyme-digested/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "skin-aging",
        "immune-system",
        "oral-health",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "38666450",
      "year": 2024,
      "title": "Endogenous Melanin and Hydrogen-Based Specific Activated Theranostics Nanoagents: A Novel Multi-Treatment Paradigm for Rheumatoid Arthritis.",
      "title_en": null,
      "title_de": "Endogenes Melanin und wasserstoffbasierte spezifisch aktivierte theranostische Nanoagenzien: Ein neuartiges Multi-Behandlungsparadigma für rheumatoide Arthritis",
      "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
      "authors": "Chen et al.",
      "author_search": "chen chen",
      "doi": "10.1002/advs.202401046",
      "doi_url": "https://doi.org/10.1002/advs.202401046",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38666450/",
      "url": "https://h2medicine.org/studies/study-chen-2024-endogenous-melanin-specific-activated/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "skin-aging",
        "joints-rheumatology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "38642971",
      "year": 2024,
      "title": "The synergistic potential of hydrogen inhalation and hyperbaric oxygen therapy.",
      "title_en": null,
      "title_de": "Das synergistische Potenzial von Wasserstoffinhalation und hyperbarer Sauerstofftherapie",
      "journal": "Journal of vascular surgery",
      "authors": "James et al.",
      "author_search": "james james",
      "doi": "10.1016/j.jvs.2023.11.067",
      "doi_url": "https://doi.org/10.1016/j.jvs.2023.11.067",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38642971/",
      "url": "https://h2medicine.org/studies/study-james-2024-synergistic-inhalation-hyperbaric-oxygen/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "38637698",
      "year": 2024,
      "title": "Hydrogen inhalation therapy for inflammation and eye diseases: a review of the literature.",
      "title_en": null,
      "title_de": "Wasserstoffinhalationstherapie bei Entzündungen und Augenerkrankungen: Eine Übersichtsarbeit der Literatur",
      "journal": "Eye (London, England)",
      "authors": "Takefuji",
      "author_search": "takefuji takefuji",
      "doi": "10.1038/s41433-024-03083-4",
      "doi_url": "https://doi.org/10.1038/s41433-024-03083-4",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38637698/",
      "url": "https://h2medicine.org/studies/study-takefuji-2024-inhalation-inflammation-eye-diseases/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "eye",
        "immune-system"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "38479178",
      "year": 2024,
      "title": "Decoupling the mutual promotion of inflammation and oxidative stress mitigates cognitive decline and depression-like behavior in rmTBI mice by promoting myelin renewal and neuronal survival.",
      "title_en": null,
      "title_de": "Die Entkopplung der gegenseitigen Förderung von Entzündung und oxidativem Stress mildert den kognitiven Abbau und depressionsähnliches Verhalten bei rmTBI-Mäusen durch Förderung der Myelinerneuerung und des Neuronenüberlebens",
      "journal": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie",
      "authors": "Lu et al.",
      "author_search": "lu lu",
      "doi": "10.1016/j.biopha.2024.116419",
      "doi_url": "https://doi.org/10.1016/j.biopha.2024.116419",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38479178/",
      "url": "https://h2medicine.org/studies/study-lu-2024-decoupling-mutual-promotion-inflammation/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "neurology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "38399533",
      "year": 2024,
      "title": "The Benefit of Hydrogen Gas as an Adjunctive Therapy for Chronic Obstructive Pulmonary Disease.",
      "title_en": null,
      "title_de": "Der Nutzen von Wasserstoffgas als adjuvante Therapie bei chronisch obstruktiver Lungenerkrankung.",
      "journal": "Medicina (Kaunas, Lithuania)",
      "authors": "Liu et al.",
      "author_search": "liu liu",
      "doi": "10.3390/medicina60020245",
      "doi_url": "https://doi.org/10.3390/medicina60020245",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38399533/",
      "url": "https://h2medicine.org/studies/study-liu-2024-benefit-adjunctive-chronic-obstructive/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "neurology",
        "respiratory",
        "immune-system",
        "oxidative-stress",
        "fundamentals-safety"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "38395800",
      "year": 2024,
      "title": "Molecular hydrogen attenuates sepsis-induced cardiomyopathy in mice by promoting autophagy.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff schwächt die sepsisinduzierte Kardiomyopathie bei Mäusen durch Förderung der Autophagie ab",
      "journal": "BMC anesthesiology",
      "authors": "Cui et al.",
      "author_search": "cui cui",
      "doi": "10.1186/s12871-024-02462-4",
      "doi_url": "https://doi.org/10.1186/s12871-024-02462-4",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38395800/",
      "url": "https://h2medicine.org/studies/study-cui-2024-attenuates-sepsis-induced-cardiomyopathy/",
      "methods": [
        "inhalation",
        "saline-iv"
      ],
      "indications": [
        "cardiovascular",
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "38382672",
      "year": 2024,
      "title": "Charge neutralization and β-elimination cleavage mechanism of family 42 L-rhamnose-α-1,4-D-glucuronate lyase revealed using neutron crystallography.",
      "title_en": null,
      "title_de": "Ladungsneutralisierung und β-Eliminierungs-Spaltungsmechanismus der L-Rhamnose-α-1,4-D-Glucuronat-Lyase der Familie 42, aufgeklärt mittels Neutronenkristallographie",
      "journal": "The Journal of biological chemistry",
      "authors": "Yano et al.",
      "author_search": "yano yano",
      "doi": "10.1016/j.jbc.2024.105774",
      "doi_url": "https://doi.org/10.1016/j.jbc.2024.105774",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38382672/",
      "url": "https://h2medicine.org/studies/study-yano-2024-charge-neutralization-elimination-cleavage/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "joints-rheumatology"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "38284276",
      "year": 2024,
      "title": "Successful treatment of Behçet's disease ulcers and skin lesions with hydrogen water.",
      "title_en": null,
      "title_de": "Erfolgreiche Behandlung von Ulzera und Hautläsionen beim Morbus Behçet mit Wasserstoffwasser.",
      "journal": "International journal of dermatology",
      "authors": "Guan et al.",
      "author_search": "guan guan",
      "doi": "10.1111/ijd.16958",
      "doi_url": "https://doi.org/10.1111/ijd.16958",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38284276/",
      "url": "https://h2medicine.org/studies/study-guan-2024-successful-behcet-disease-ulcers/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "skin-aging"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "37929512",
      "year": 2024,
      "title": "Successful treatment of myalgic encephalomyelitis/chronic fatigue syndrome using hydrogen gas: four case reports.",
      "title_en": null,
      "title_de": "Erfolgreiche Behandlung der myalgischen Enzephalomyelitis/des chronischen Erschöpfungssyndroms mit Wasserstoffgas: Vier Fallberichte.",
      "journal": "Medical gas research",
      "authors": "Hirano et al.",
      "author_search": "hirano hirano",
      "doi": "10.4103/2045-9912.385441",
      "doi_url": "https://doi.org/10.4103/2045-9912.385441",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/37929512/",
      "url": "https://h2medicine.org/studies/study-hirano-2024-successful-myalgic-encephalomyelitis-chronic/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "39258790",
      "year": 2024,
      "title": "High-concentration hydrogen inhalation mitigates sepsis-associated encephalopathy in mice by improving mitochondrial dynamics",
      "title_en": null,
      "title_de": "Das Einatmen von hochkonzentriertem Wasserstoff mildert die sepsisassoziierte Enzephalopathie bei Mäusen durch Verbesserung der Mitochondrien-Dynamik",
      "journal": "CNS Neuroscience & Therapeutics",
      "authors": "Cui et al.",
      "author_search": "cui cui",
      "doi": "10.1111/cns.70021",
      "doi_url": "https://doi.org/10.1111/cns.70021",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39258790/",
      "url": "https://h2medicine.org/studies/study-cui-2024-high-concentration-sepsis-encephalopathy-mitochondrial/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "neurology",
        "fundamentals",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "39328786",
      "year": 2024,
      "title": "Natural hydrogen gas and engineered microalgae prevent acute lung injury in sepsis",
      "title_en": null,
      "title_de": "Natürliches Wasserstoffgas und maßgeschneiderte Mikroalgen verhindern akuten Lungenschaden bei Sepsis",
      "journal": "Materials Today Bio",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1016/j.mtbio.2024.101247",
      "doi_url": "https://doi.org/10.1016/j.mtbio.2024.101247",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39328786/",
      "url": "https://h2medicine.org/studies/study-wang-2024-engineered-microalgae-acute-lung-injury-sepsis/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "respiratory",
        "oxidative-stress",
        "fundamentals"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "36708550",
      "year": 2023,
      "title": "A Systematic Review of Molecular Hydrogen Therapy in Cancer Management.",
      "title_en": null,
      "title_de": "Ein systematischer Review der molekularen Wasserstofftherapie in der Krebsbehandlung",
      "journal": "Asian Pacific Journal of Cancer Prevention",
      "authors": "Mohd Noor et al.",
      "author_search": "mohd noor mohd noor",
      "doi": "10.31557/apjcp.2023.24.1.37",
      "doi_url": "https://doi.org/10.31557/apjcp.2023.24.1.37",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36708550/",
      "url": "https://h2medicine.org/studies/study-mohd-noor-2023-cancer-management-systematic-review/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "oxidative-stress",
        "immune-system"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "36978884",
      "year": 2023,
      "title": "Molecular Hydrogen: From Molecular Effects to Stem Cells Management and Tissue Regeneration",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff: Von molekularen Effekten bis zum Stammzell-Management und zur Geweberegeneration",
      "journal": "Antioxidants (Basel)",
      "authors": "Artamonov et al.",
      "author_search": "artamonov artamonov",
      "doi": "10.3390/antiox12030636",
      "doi_url": "https://doi.org/10.3390/antiox12030636",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36978884/",
      "url": "https://h2medicine.org/studies/study-artamonov-2023-stem-cells-tissue-regeneration/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "fundamentals",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "37988743",
      "year": 2023,
      "title": "Molecular Hydrogen: Emerging Treatment for Stroke Management",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff: Aufkommende Behandlung für das Schlaganfall-Management",
      "journal": "Chemical Research in Toxicology",
      "authors": "Kuo et al.",
      "author_search": "kuo kuo",
      "doi": "10.1021/acs.chemrestox.3c00259",
      "doi_url": "https://doi.org/10.1021/acs.chemrestox.3c00259",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/37988743/",
      "url": "https://h2medicine.org/studies/study-kuo-2023-stroke-management/",
      "methods": [
        "inhalation",
        "saline-iv",
        "drinking-hrw"
      ],
      "indications": [
        "neurology",
        "cardiovascular",
        "fundamentals",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "38067515",
      "year": 2023,
      "title": "Molecular Hydrogen Therapy-A Review on Clinical Studies and Outcomes.",
      "title_en": null,
      "title_de": "Molekulare Wasserstofftherapie – Eine Übersichtsarbeit zu klinischen Studien und Ergebnissen",
      "journal": "Molecules (Basel, Switzerland)",
      "authors": "Johnsen et al.",
      "author_search": "johnsen johnsen",
      "doi": "10.3390/molecules28237785",
      "doi_url": "https://doi.org/10.3390/molecules28237785",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38067515/",
      "url": "https://h2medicine.org/studies/study-johnsen-2023-review-outcomes/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cardiovascular",
        "cancer",
        "respiratory",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "37913734",
      "year": 2023,
      "title": "The role of hydrogen therapy in Alzheimer's disease management: Insights into mechanisms, administration routes, and future challenges.",
      "title_en": null,
      "title_de": "Die Rolle der Wasserstofftherapie im Management der Alzheimer-Krankheit: Einblicke in Mechanismen, Verabreichungswege und zukünftige Herausforderungen",
      "journal": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie",
      "authors": "He et al.",
      "author_search": "he he",
      "doi": "10.1016/j.biopha.2023.115807",
      "doi_url": "https://doi.org/10.1016/j.biopha.2023.115807",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/37913734/",
      "url": "https://h2medicine.org/studies/study-he-2023-alzheimer-disease-management-insights/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "neurology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "37269385",
      "year": 2023,
      "title": "Hydrogen therapy as a potential therapeutic intervention in heart disease: from the past evidence to future application.",
      "title_en": null,
      "title_de": "Die Wasserstofftherapie als potenzielle therapeutische Intervention bei Herzerkrankungen: Von der bisherigen Evidenz zur zukünftigen Anwendung",
      "journal": "Cellular and molecular life sciences : CMLS",
      "authors": "Saengsin et al.",
      "author_search": "saengsin saengsin",
      "doi": "10.1007/s00018-023-04818-4",
      "doi_url": "https://doi.org/10.1007/s00018-023-04818-4",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/37269385/",
      "url": "https://h2medicine.org/studies/study-saengsin-2023-therapeutic-intervention-heart-disease/",
      "methods": [
        "inhalation",
        "saline-iv",
        "bath-topical",
        "drinking-hrw"
      ],
      "indications": [
        "cardiovascular",
        "cancer",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "36930488",
      "year": 2023,
      "title": "Novel therapeutic approaches based on the pathological role of gut dysbiosis on the link between nonalcoholic fatty liver disease and insulin resistance.",
      "title_en": null,
      "title_de": "Neuartige therapeutische Ansätze auf Basis der pathologischen Rolle der Darmdysbiose für den Zusammenhang zwischen nichtalkoholischer Fettlebererkrankung und Insulinresistenz",
      "journal": "European review for medical and pharmacological sciences",
      "authors": "Bellucci et al.",
      "author_search": "bellucci bellucci",
      "doi": "10.26355/eurrev_202303_31558",
      "doi_url": "https://doi.org/10.26355/eurrev_202303_31558",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36930488/",
      "url": "https://h2medicine.org/studies/study-bellucci-2023-therapeutic-approaches-pathological-gut/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "diabetes",
        "metabolic",
        "liver",
        "immune-system"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "36571374",
      "year": 2023,
      "title": "The overlooked benefits of hydrogen-producing bacteria.",
      "title_en": null,
      "title_de": "Die übersehenen Vorteile wasserstoffproduzierender Bakterien",
      "journal": "Medical gas research",
      "authors": "Ichikawa et al.",
      "author_search": "ichikawa ichikawa",
      "doi": "10.4103/2045-9912.344977",
      "doi_url": "https://doi.org/10.4103/2045-9912.344977",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36571374/",
      "url": "https://h2medicine.org/studies/study-ichikawa-2023-overlooked-benefits-producing-bacteria/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "36567361",
      "year": 2023,
      "title": "Molecular Hydrogen: an Emerging Therapeutic Medical Gas for Brain Disorders.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff: Ein aufkommendes therapeutisches medizinisches Gas für Hirnerkrankungen",
      "journal": "Molecular neurobiology",
      "authors": "Wu et al.",
      "author_search": "wu wu",
      "doi": "10.1007/s12035-022-03175-w",
      "doi_url": "https://doi.org/10.1007/s12035-022-03175-w",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36567361/",
      "url": "https://h2medicine.org/studies/study-wu-2023-emerging-therapeutic-medical-brain/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "neurology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "36204784",
      "year": 2023,
      "title": "Molecular hydrogen exposure improves functional state of red blood cells in the early postoperative period: a randomized clinical study",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff verbessert den Funktionszustand roter Blutkörperchen in der frühen postoperativen Phase: eine randomisierte klinische Studie",
      "journal": "Medical Gas Research",
      "authors": "Deryugina et al.",
      "author_search": "deryugina deryugina",
      "doi": "10.4103/2045-9912.356473",
      "doi_url": "https://doi.org/10.4103/2045-9912.356473",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36204784/",
      "url": "https://h2medicine.org/studies/study-deryugina-2023-red-blood-cells-postoperative/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cardiovascular",
        "oxidative-stress"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "36675728",
      "year": 2023,
      "title": "Hydrogen Gas Treatment Improves Postoperative Delirium and Cognitive Dysfunction in Elderly Noncardiac Patients",
      "title_en": null,
      "title_de": "Wasserstoffgas-Behandlung verbessert postoperatives Delir und kognitive Dysfunktion bei älteren nicht-kardialen Patienten",
      "journal": "Journal of Personalized Medicine",
      "authors": "Lin et al.",
      "author_search": "lin lin",
      "doi": "10.3390/jpm13010067",
      "doi_url": "https://doi.org/10.3390/jpm13010067",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36675728/",
      "url": "https://h2medicine.org/studies/study-lin-2023-gas-treatment-postoperative-delirium-elderly/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "neurology"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "37567773",
      "year": 2023,
      "title": "EFFECT OF ACUTE HYDROGEN-RICH WATER INTAKE ON INTRAOCULAR PRESSURE IN HEALTHY SUBJECTS",
      "title_en": null,
      "title_de": "Effekt der akuten Aufnahme von wasserstoffreichem Wasser auf den Augeninnendruck bei gesunden Probanden",
      "journal": "Ceska a slovenska oftalmologie",
      "authors": "Najmanová et al.",
      "author_search": "najmanová najmanová",
      "doi": "10.31348/2023/23",
      "doi_url": "https://doi.org/10.31348/2023/23",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/37567773/",
      "url": "https://h2medicine.org/studies/study-najmanova-2023-intraocular-pressure-healthy-subjects/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "eye",
        "oxidative-stress"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "38156844",
      "year": 2023,
      "title": "The Inhibition Mechanism of Pancreatic Ductal Adenocarcinoma via LXR Receptors: A Multifaceted Approach Integrating Molecular Docking, Molecular Dynamics and Post-MD Inter-Molecular Contact Analysis.",
      "title_en": null,
      "title_de": "Der Hemmmechanismus des duktalen Pankreasadenokarzinoms über LXR-Rezeptoren: Ein vielschichtiger Ansatz unter Integration von molekularem Docking, Moleküldynamik und Post-MD-Intermolekular-Kontaktanalyse",
      "journal": "Asian Pacific journal of cancer prevention : APJCP",
      "authors": "Agar et al.",
      "author_search": "agar agar",
      "doi": "10.31557/apjcp.2023.24.12.4103",
      "doi_url": "https://doi.org/10.31557/apjcp.2023.24.12.4103",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38156844/",
      "url": "https://h2medicine.org/studies/study-agar-2023-inhibition-mechanism-pancreatic-ductal/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "metabolic",
        "liver",
        "cancer",
        "skin-aging",
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "37797471",
      "year": 2023,
      "title": "The effect of hydrogen-rich water on letrozole-induced polycystic ovary syndrome in rats.",
      "title_en": null,
      "title_de": "Die Wirkung von wasserstoffreichem Wasser auf das letrozolinduzierte polyzystische Ovarialsyndrom bei Ratten",
      "journal": "Reproductive biomedicine online",
      "authors": "Makav et al.",
      "author_search": "makav makav",
      "doi": "10.1016/j.rbmo.2023.103332",
      "doi_url": "https://doi.org/10.1016/j.rbmo.2023.103332",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/37797471/",
      "url": "https://h2medicine.org/studies/study-makav-2023-letrozole-induced-polycystic-ovary/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "womens-health",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "37734117",
      "year": 2023,
      "title": "Hydrogen-rich water upregulates fecal propionic acid levels in overweight adults.",
      "title_en": null,
      "title_de": "Wasserstoffreiches Wasser erhöht die fäkalen Propionsäurespiegel bei übergewichtigen Erwachsenen.",
      "journal": "Nutrition (Burbank, Los Angeles County, Calif.)",
      "authors": "Korovljev et al.",
      "author_search": "korovljev korovljev",
      "doi": "10.1016/j.nut.2023.112200",
      "doi_url": "https://doi.org/10.1016/j.nut.2023.112200",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/37734117/",
      "url": "https://h2medicine.org/studies/study-korovljev-2023-upregulates-fecal-propionic-acid/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "metabolic"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "37726384",
      "year": 2023,
      "title": "Changes in the negative logarithm of end-tidal hydrogen partial pressure indicate the variation of electrode potential in healthy Japanese subjects.",
      "title_en": null,
      "title_de": "Veränderungen im negativen Logarithmus des endexspiratorischen Wasserstoffpartialdrucks weisen auf die Variation des Elektrodenpotenzials bei gesunden japanischen Probanden hin.",
      "journal": "Scientific reports",
      "authors": "Kiyama et al.",
      "author_search": "kiyama kiyama",
      "doi": "10.1038/s41598-023-42651-8",
      "doi_url": "https://doi.org/10.1038/s41598-023-42651-8",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/37726384/",
      "url": "https://h2medicine.org/studies/study-kiyama-2023-changes-negative-logarithm-end/",
      "methods": [],
      "indications": [
        "other"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "37587791",
      "year": 2023,
      "title": "Ultrasound-Driven Piezoelectrocatalytic Immunoactivation of Deep Tumor.",
      "title_en": null,
      "title_de": "Ultraschallgetriebene piezoelektrokatalytische Immunaktivierung tiefer Tumoren",
      "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
      "authors": "Wu et al.",
      "author_search": "wu wu",
      "doi": "10.1002/advs.202303016",
      "doi_url": "https://doi.org/10.1002/advs.202303016",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/37587791/",
      "url": "https://h2medicine.org/studies/study-wu-2023-ultrasound-driven-piezoelectrocatalytic-immunoactivation/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "liver",
        "cancer"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "37572992",
      "year": 2023,
      "title": "Attenuation of pulmonary damage in aged lipopolysaccharide-induced inflammation mice through continuous 2 % hydrogen gas inhalation: A potential therapeutic strategy for geriatric inflammation and survival.",
      "title_en": null,
      "title_de": "Abschwächung pulmonaler Schäden bei gealterten, lipopolysaccharidinduzierten Entzündungsmäusen durch kontinuierliche Inhalation von 2 % Wasserstoffgas: Eine potenzielle therapeutische Strategie für geriatrische Entzündung und Überleben",
      "journal": "Experimental gerontology",
      "authors": "Aokage et al.",
      "author_search": "aokage aokage",
      "doi": "10.1016/j.exger.2023.112270",
      "doi_url": "https://doi.org/10.1016/j.exger.2023.112270",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/37572992/",
      "url": "https://h2medicine.org/studies/study-aokage-2023-attenuation-pulmonary-damage-aged/",
      "methods": [
        "inhalation",
        "saline-iv"
      ],
      "indications": [
        "liver",
        "sports-exercise",
        "cancer",
        "respiratory",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "37569850",
      "year": 2023,
      "title": "The Effect of Adjuvant Therapy with Molecular Hydrogen on Endogenous Coenzyme Q10 Levels and Platelet Mitochondrial Bioenergetics in Patients with Non-Alcoholic Fatty Liver Disease.",
      "title_en": null,
      "title_de": "Die Wirkung der adjuvanten Therapie mit molekularem Wasserstoff auf die endogenen Coenzym-Q10-Spiegel und die mitochondriale Bioenergetik der Thrombozyten bei Patienten mit nichtalkoholischer Fettlebererkrankung.",
      "journal": "International journal of molecular sciences",
      "authors": "Sumbalová et al.",
      "author_search": "sumbalová sumbalová",
      "doi": "10.3390/ijms241512477",
      "doi_url": "https://doi.org/10.3390/ijms241512477",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/37569850/",
      "url": "https://h2medicine.org/studies/study-sumbalova-2023-adjuvant-endogenous-coenzyme-q10/",
      "methods": [
        "tablets",
        "drinking-hrw"
      ],
      "indications": [
        "liver",
        "sports-exercise",
        "immune-system",
        "oxidative-stress",
        "fundamentals-safety"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "37556997",
      "year": 2023,
      "title": "Hydrogen-rich saline regulates NLRP3 inflammasome activation in sepsis-associated encephalopathy rat model.",
      "title_en": null,
      "title_de": "Wasserstoffreiche Kochsalzlösung reguliert die Aktivierung des NLRP3-Inflammasoms in einem Rattenmodell der sepsisassoziierten Enzephalopathie",
      "journal": "International immunopharmacology",
      "authors": "Dumbuya et al.",
      "author_search": "dumbuya dumbuya",
      "doi": "10.1016/j.intimp.2023.110758",
      "doi_url": "https://doi.org/10.1016/j.intimp.2023.110758",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/37556997/",
      "url": "https://h2medicine.org/studies/study-dumbuya-2023-saline-regulates-nlrp3-inflammasome/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "neurology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "37397014",
      "year": 2023,
      "title": "Hydrogen-rich water treatment targets RT1-Db1 and RT1-Bb to alleviate premature ovarian failure in rats.",
      "title_en": null,
      "title_de": "Die Behandlung mit wasserstoffreichem Wasser zielt auf RT1-Db1 und RT1-Bb ab, um vorzeitiges Ovarialversagen bei Ratten zu lindern",
      "journal": "PeerJ",
      "authors": "Meng et al.",
      "author_search": "meng meng",
      "doi": "10.7717/peerj.15564",
      "doi_url": "https://doi.org/10.7717/peerj.15564",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/37397014/",
      "url": "https://h2medicine.org/studies/study-meng-2023-targets-rt1-db1-rt1/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "womens-health"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "37322527",
      "year": 2023,
      "title": "H2 generated by fermentation in the human gut microbiome influences metabolism and competitive fitness of gut butyrate producers.",
      "title_en": null,
      "title_de": "Durch Fermentation im menschlichen Darm erzeugter H₂ beeinflusst den Stoffwechsel und die kompetitive Fitness von Darmbutyratproduzenten.",
      "journal": "Microbiome",
      "authors": "Campbell et al.",
      "author_search": "campbell campbell",
      "doi": "10.1186/s40168-023-01565-3",
      "doi_url": "https://doi.org/10.1186/s40168-023-01565-3",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/37322527/",
      "url": "https://h2medicine.org/studies/study-campbell-2023-generated-fermentation-gut-microbiome/",
      "methods": [],
      "indications": [
        "immune-system"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "byproduct"
    },
    {
      "pmid": "37196556",
      "year": 2023,
      "title": "Hydrogen gas ameliorates acute alcoholic liver injury via anti-inflammatory and antioxidant effects and regulation of intestinal microbiota.",
      "title_en": null,
      "title_de": "Wasserstoffgas lindert akute alkoholische Leberschäden über entzündungshemmende und antioxidative Wirkungen sowie die Regulation der Darmmikrobiota",
      "journal": "International immunopharmacology",
      "authors": "Liu et al.",
      "author_search": "liu liu",
      "doi": "10.1016/j.intimp.2023.110252",
      "doi_url": "https://doi.org/10.1016/j.intimp.2023.110252",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/37196556/",
      "url": "https://h2medicine.org/studies/study-liu-2023-ameliorates-acute-alcoholic-liver/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "metabolic",
        "liver",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "37077121",
      "year": 2023,
      "title": "Trend of research on the medical use of molecular hydrogen: a bibliometric analysis.",
      "title_en": null,
      "title_de": "Trend der Forschung zur medizinischen Anwendung von molekularem Wasserstoff: Eine bibliometrische Analyse",
      "journal": "Medical gas research",
      "authors": "Li et al.",
      "author_search": "li li",
      "doi": "10.4103/2045-9912.344980",
      "doi_url": "https://doi.org/10.4103/2045-9912.344980",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/37077121/",
      "url": "https://h2medicine.org/studies/study-li-2023-trend-research-medical-use/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "respiratory",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "36912868",
      "year": 2023,
      "title": "Inorganic Nanosheet-Shielded Probiotics: A Self-Adaptable Oral Delivery System for Intestinal Disease Treatment.",
      "title_en": null,
      "title_de": "Mit anorganischen Nanoschichten abgeschirmte Probiotika: Ein selbstanpassendes orales Verabreichungssystem zur Behandlung von Darmerkrankungen",
      "journal": "Nano letters",
      "authors": "Zhu et al.",
      "author_search": "zhu zhu",
      "doi": "10.1021/acs.nanolett.3c00118",
      "doi_url": "https://doi.org/10.1021/acs.nanolett.3c00118",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36912868/",
      "url": "https://h2medicine.org/studies/study-zhu-2023-inorganic-nanosheet-shielded-probiotics/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "liver",
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "36807963",
      "year": 2023,
      "title": "Intermittent environmental exposure to hydrogen prevents skin photoaging through reduction of oxidative stress.",
      "title_en": null,
      "title_de": "Intermittierende umweltbedingte Exposition gegenüber Wasserstoff verhindert Hautphotoalterung durch Reduktion von oxidativem Stress",
      "journal": "Geriatrics & gerontology international",
      "authors": "Kiyoi et al.",
      "author_search": "kiyoi kiyoi",
      "doi": "10.1111/ggi.14562",
      "doi_url": "https://doi.org/10.1111/ggi.14562",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36807963/",
      "url": "https://h2medicine.org/studies/study-kiyoi-2023-intermittent-environmental-exposure-prevents/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cancer",
        "skin-aging",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "36778204",
      "year": 2023,
      "title": "pH-Responsive Delivery of H2 through Ammonia Borane-Loaded Hollow Polydopamine for Intervertebral Disc Degeneration Therapy.",
      "title_en": null,
      "title_de": "pH-responsive Abgabe von H₂ durch Ammoniak-Boran-beladenes hohles Polydopamin zur Therapie der Bandscheibendegeneration",
      "journal": "Oxidative medicine and cellular longevity",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1155/2023/7773609",
      "doi_url": "https://doi.org/10.1155/2023/7773609",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36778204/",
      "url": "https://h2medicine.org/studies/study-wang-2023-responsive-delivery-through-ammonia/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "36768345",
      "year": 2023,
      "title": "Biological Activity of Novel Organotin Compounds with a Schiff Base Containing an Antioxidant Fragment.",
      "title_en": null,
      "title_de": "Biologische Aktivität neuartiger Organozinnverbindungen mit einer Schiff-Base, die ein antioxidatives Fragment enthält",
      "journal": "International journal of molecular sciences",
      "authors": "Antonenko et al.",
      "author_search": "antonenko antonenko",
      "doi": "10.3390/ijms24032024",
      "doi_url": "https://doi.org/10.3390/ijms24032024",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36768345/",
      "url": "https://h2medicine.org/studies/study-antonenko-2023-biological-activity-organotin-compounds/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "36596238",
      "year": 2023,
      "title": "PdO-Nanoparticle-Embedded Carbon Nanotube Yarns for Wearable Hydrogen Gas Sensing Platforms with Fast and Sensitive Responses.",
      "title_en": null,
      "title_de": "PdO-Nanopartikel-eingebettete Kohlenstoffnanoröhren-Garne für tragbare Wasserstoffgas-Sensorplattformen mit schnellen und empfindlichen Reaktionen",
      "journal": "ACS sensors",
      "authors": "Son et al.",
      "author_search": "son son",
      "doi": "10.1021/acssensors.2c01743",
      "doi_url": "https://doi.org/10.1021/acssensors.2c01743",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36596238/",
      "url": "https://h2medicine.org/studies/study-son-2023-pdo-nanoparticle-embedded-carbon/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "sports-exercise",
        "joints-rheumatology",
        "fundamentals-safety"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "36571379",
      "year": 2023,
      "title": "H2-induced transient upregulation of phospholipids with suppression of energy metabolism.",
      "title_en": null,
      "title_de": "H₂-induzierte vorübergehende Hochregulierung von Phospholipiden bei gleichzeitiger Unterdrückung des Energiestoffwechsels",
      "journal": "Medical gas research",
      "authors": "Iketani et al.",
      "author_search": "iketani iketani",
      "doi": "10.4103/2045-9912.344973",
      "doi_url": "https://doi.org/10.4103/2045-9912.344973",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36571379/",
      "url": "https://h2medicine.org/studies/study-iketani-2023-induced-transient-upregulation-phospholipids/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "metabolic",
        "sports-exercise",
        "neurology",
        "cardiovascular",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "36546774",
      "year": 2023,
      "title": "Two-Dimensional Mg2 Si Nanosheet-Enabled Sustained Hydrogen Generation for Improved Repair and Regeneration of Deeply Burned Skin.",
      "title_en": null,
      "title_de": "Zweidimensionale Mg₂Si-Nanoschichten ermöglichen eine anhaltende Wasserstofferzeugung zur verbesserten Reparatur und Regeneration tief verbrannter Haut",
      "journal": "Advanced healthcare materials",
      "authors": "Zhu et al.",
      "author_search": "zhu zhu",
      "doi": "10.1002/adhm.202201705",
      "doi_url": "https://doi.org/10.1002/adhm.202201705",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36546774/",
      "url": "https://h2medicine.org/studies/study-zhu-2023-two-dimensional-mg2-nanosheet/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "skin-aging",
        "immune-system",
        "oxidative-stress",
        "fundamentals-safety"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "36529921",
      "year": 2023,
      "title": "Hydrogen-producing Photocatalyst at Sunscreen for Athletes in Preventing and Healing Muscle-nerve-skin Injuries.",
      "title_en": null,
      "title_de": "Wasserstoffproduzierender Photokatalysator in Sonnenschutzmitteln für Sportler zur Prävention und Heilung von Muskel-Nerven-Haut-Verletzungen",
      "journal": "Current topics in medicinal chemistry",
      "authors": "Sahoo",
      "author_search": "sahoo sahoo",
      "doi": "10.2174/1568026623666221216142158",
      "doi_url": "https://doi.org/10.2174/1568026623666221216142158",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36529921/",
      "url": "https://h2medicine.org/studies/study-sahoo-2023-producing-photocatalyst-sunscreen-athletes/",
      "methods": [
        "bath-topical"
      ],
      "indications": [
        "liver",
        "sports-exercise",
        "neurology",
        "cancer",
        "skin-aging"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "36516898",
      "year": 2023,
      "title": "Effects of molecular hydrogen intervention on the gut microbiome in methamphetamine abusers with mental disorder.",
      "title_en": null,
      "title_de": "Auswirkungen einer Intervention mit molekularem Wasserstoff auf das Darmmikrobiom bei Methamphetaminkonsumenten mit psychischer Störung.",
      "journal": "Brain research bulletin",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1016/j.brainresbull.2022.12.003",
      "doi_url": "https://doi.org/10.1016/j.brainresbull.2022.12.003",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36516898/",
      "url": "https://h2medicine.org/studies/study-wang-2023-intervention-gut-microbiome-methamphetamine/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "neurology"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "36460289",
      "year": 2023,
      "title": "Long-term in vivo observations show biocompatibility and performance of ZX00 magnesium screws surface-modified by plasma-electrolytic oxidation in Göttingen miniature pigs.",
      "title_en": null,
      "title_de": "Langzeit-In-vivo-Beobachtungen zeigen Biokompatibilität und Leistung von ZX00-Magnesiumschrauben, deren Oberfläche durch plasmaelektrolytische Oxidation modifiziert wurde, bei Göttinger Miniaturschweinen",
      "journal": "Acta biomaterialia",
      "authors": "Kopp et al.",
      "author_search": "kopp kopp",
      "doi": "10.1016/j.actbio.2022.11.052",
      "doi_url": "https://doi.org/10.1016/j.actbio.2022.11.052",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36460289/",
      "url": "https://h2medicine.org/studies/study-kopp-2023-long-term-vivo-observations/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "36330842",
      "year": 2023,
      "title": "Hydrogen suppresses oxidative stress by inhibiting the p38 MAPK signaling pathway in preeclampsia.",
      "title_en": null,
      "title_de": "Wasserstoff unterdrückt oxidativen Stress durch Hemmung des p38-MAPK-Signalwegs bei Präeklampsie",
      "journal": "Advances in clinical and experimental medicine : official organ Wroclaw Medical University",
      "authors": "Guo et al.",
      "author_search": "guo guo",
      "doi": "10.17219/acem/154623",
      "doi_url": "https://doi.org/10.17219/acem/154623",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36330842/",
      "url": "https://h2medicine.org/studies/study-guo-2023-suppresses-oxidative-stress-inhibiting/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "cardiovascular",
        "cancer",
        "kidney-dialysis",
        "pregnancy",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "36307299",
      "year": 2023,
      "title": "A potential clinical application of hydrogen-rich saline in postoperative care.",
      "title_en": null,
      "title_de": "Eine potenzielle klinische Anwendung von wasserstoffreicher Kochsalzlösung in der postoperativen Versorgung",
      "journal": "Journal of pediatric surgery",
      "authors": "Wong et al.",
      "author_search": "wong wong",
      "doi": "10.1016/j.jpedsurg.2022.09.041",
      "doi_url": "https://doi.org/10.1016/j.jpedsurg.2022.09.041",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36307299/",
      "url": "https://h2medicine.org/studies/study-wong-2023-application-saline-postoperative-care/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "36165523",
      "year": 2023,
      "title": "Molecular Hydrogen Promotes Adipose-derived Stem Cell Myogenic Differentiation via Regulation of Mitochondria.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff fördert die myogene Differenzierung von aus Fettgewebe stammenden Stammzellen über die Regulation der Mitochondrien",
      "journal": "Current stem cell research & therapy",
      "authors": "Yang et al.",
      "author_search": "yang yang",
      "doi": "10.2174/1574888x17666220926115240",
      "doi_url": "https://doi.org/10.2174/1574888x17666220926115240",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36165523/",
      "url": "https://h2medicine.org/studies/study-yang-2023-promotes-adipose-derived-stem/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "metabolic",
        "sports-exercise",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "35962590",
      "year": 2023,
      "title": "Hydrogen Gas Inhalation Attenuates Acute Impulse Noise Trauma: A Preclinical In Vivo Study.",
      "title_en": null,
      "title_de": "Die Inhalation von Wasserstoffgas schwächt akute Impulslärm-Traumata ab: Eine präklinische In-vivo-Studie",
      "journal": "The Annals of otology, rhinology, and laryngology",
      "authors": "Videhult Pierre et al.",
      "author_search": "videhult pierre videhult pierre",
      "doi": "10.1177/00034894221118764",
      "doi_url": "https://doi.org/10.1177/00034894221118764",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35962590/",
      "url": "https://h2medicine.org/studies/study-videhultpierre-2023-inhalation-attenuates-acute-impulse/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "36499079",
      "year": 2022,
      "title": "Electrolyzed-Reduced Water: Review I. Molecular Hydrogen Is the Exclusive Agent Responsible for the Therapeutic Effects",
      "title_en": null,
      "title_de": "Elektrolytisch reduziertes Wasser, Review I: Molekularer Wasserstoff ist der alleinige Wirkstoff für die therapeutischen Effekte",
      "journal": "International Journal of Molecular Sciences",
      "authors": "LeBaron et al.",
      "author_search": "lebaron le baron",
      "doi": "10.3390/ijms232314750",
      "doi_url": "https://doi.org/10.3390/ijms232314750",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36499079/",
      "url": "https://h2medicine.org/studies/study-lebaron-2022-electrolyzed-reduced-water-exclusive-agent/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "fundamentals",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "35920994",
      "year": 2022,
      "title": "Impact of nutraceuticals and dietary supplements on mitochondria modifications in healthy aging: a systematic review of randomized controlled trials.",
      "title_en": null,
      "title_de": "Auswirkungen von Nutrazeutika und Nahrungsergänzungsmitteln auf mitochondriale Veränderungen beim gesunden Altern: Eine systematische Übersichtsarbeit randomisierter kontrollierter Studien",
      "journal": "Aging clinical and experimental research",
      "authors": "Lippi et al.",
      "author_search": "lippi lippi",
      "doi": "10.1007/s40520-022-02203-y",
      "doi_url": "https://doi.org/10.1007/s40520-022-02203-y",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35920994/",
      "url": "https://h2medicine.org/studies/study-lippi-2022-impact-nutraceuticals-dietary-supplements/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "skin-aging",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "35489460",
      "year": 2022,
      "title": "Electrocoagulation and electrooxidation technologies for pesticide removal from water or wastewater: A review.",
      "title_en": null,
      "title_de": "Elektrokoagulations- und Elektrooxidationstechnologien zur Entfernung von Pestiziden aus Wasser oder Abwasser: Eine Übersichtsarbeit",
      "journal": "Chemosphere",
      "authors": "Biswas et al.",
      "author_search": "biswas biswas",
      "doi": "10.1016/j.chemosphere.2022.134709",
      "doi_url": "https://doi.org/10.1016/j.chemosphere.2022.134709",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35489460/",
      "url": "https://h2medicine.org/studies/study-biswas-2022-electrocoagulation-electrooxidation-technologies-pesticide/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "neurology",
        "cancer",
        "respiratory"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "35340218",
      "year": 2022,
      "title": "Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases.",
      "title_en": null,
      "title_de": "Die Rolle von molekularem Wasserstoff beim Altern und alternsbedingten Erkrankungen",
      "journal": "Oxidative medicine and cellular longevity",
      "authors": "Fu et al.",
      "author_search": "fu fu",
      "doi": "10.1155/2022/2249749",
      "doi_url": "https://doi.org/10.1155/2022/2249749",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35340218/",
      "url": "https://h2medicine.org/studies/study-fu-2022-ageing-ageing-related-diseases/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "diabetes",
        "neurology",
        "cardiovascular",
        "cancer",
        "respiratory",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "35240982",
      "year": 2022,
      "title": "Molecular hydrogen is a potential protective agent in the management of acute lung injury.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff ist ein potenzielles Schutzmittel im Management der akuten Lungenschädigung",
      "journal": "Molecular medicine (Cambridge, Mass.)",
      "authors": "Zhang et al.",
      "author_search": "zhang zhang",
      "doi": "10.1186/s10020-022-00455-y",
      "doi_url": "https://doi.org/10.1186/s10020-022-00455-y",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35240982/",
      "url": "https://h2medicine.org/studies/study-zhang-2022-protective-agent-management-acute/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "respiratory",
        "immune-system"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "33555824",
      "year": 2022,
      "title": "Hydrogen Rich Water Consumption Positively Affects Muscle Performance, Lactate Response, and Alleviates Delayed Onset of Muscle Soreness After Resistance Training",
      "title_en": null,
      "title_de": "Der Konsum von wasserstoffreichem Wasser wirkt sich positiv auf Muskelleistung und Laktatantwort aus und lindert den verzögert auftretenden Muskelkater nach Krafttraining",
      "journal": "Journal of Strength and Conditioning Research",
      "authors": "Botek et al.",
      "author_search": "botek botek",
      "doi": "10.1519/jsc.0000000000003979",
      "doi_url": "https://doi.org/10.1519/jsc.0000000000003979",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33555824/",
      "url": "https://h2medicine.org/studies/study-botek-2022-muscle-performance-delayed-onset-soreness-resistance-training/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "oxidative-stress"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "35206179",
      "year": 2022,
      "title": "Molecular Hydrogen Positively Affects Physical and Respiratory Function in Acute Post-COVID-19 Patients: A New Perspective in Rehabilitation",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff beeinflusst die körperliche und respiratorische Funktion bei akuten Post-COVID-19-Patienten positiv: eine neue Perspektive in der Rehabilitation",
      "journal": "International Journal of Environmental Research and Public Health",
      "authors": "Botek et al.",
      "author_search": "botek botek",
      "doi": "10.3390/ijerph19041992",
      "doi_url": "https://doi.org/10.3390/ijerph19041992",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35206179/",
      "url": "https://h2medicine.org/studies/study-botek-2022-post-covid-19-respiratory-rehabilitation/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "respiratory",
        "immune-system",
        "oxidative-stress",
        "sports-exercise"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "35276867",
      "year": 2022,
      "title": "Molecular Hydrogen Mitigates Performance Decrement during Repeated Sprints in Professional Soccer Players",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff mildert den Leistungsabfall bei wiederholten Sprints bei Profi-Fußballern",
      "journal": "Nutrients",
      "authors": "Botek et al.",
      "author_search": "botek botek",
      "doi": "10.3390/nu14030508",
      "doi_url": "https://doi.org/10.3390/nu14030508",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35276867/",
      "url": "https://h2medicine.org/studies/study-botek-2022-repeated-sprints-soccer-players/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "oxidative-stress"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "35734974",
      "year": 2022,
      "title": "A randomized, placebo-controlled clinical trial of hydrogen/oxygen inhalation for non-alcoholic fatty liver disease",
      "title_en": null,
      "title_de": "Eine randomisierte, placebokontrollierte klinische Studie zur Wasserstoff/Sauerstoff-Inhalation bei nicht-alkoholischer Fettlebererkrankung",
      "journal": "Journal of Cellular and Molecular Medicine",
      "authors": "Tao et al.",
      "author_search": "tao tao",
      "doi": "10.1111/jcmm.17456",
      "doi_url": "https://doi.org/10.1111/jcmm.17456",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35734974/",
      "url": "https://h2medicine.org/studies/study-tao-2022-oxygen-inhalation-nonalcoholic-fatty-liver/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "liver",
        "metabolic",
        "oxidative-stress"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "36538554",
      "year": 2022,
      "title": "Acute pre-exercise hydrogen rich water intake does not improve running performance at maximal aerobic speed in trained track and field runners: A randomized, double-blind, placebo-controlled crossover study",
      "title_en": null,
      "title_de": "Akute Einnahme von wasserstoffreichem Wasser vor der Belastung verbessert die Laufleistung bei maximaler aerober Geschwindigkeit bei trainierten Leichtathletik-Läufern nicht: eine randomisierte, doppelblinde, placebokontrollierte Crossover-Studie",
      "journal": "PLoS ONE",
      "authors": "Valenta et al.",
      "author_search": "valenta valenta",
      "doi": "10.1371/journal.pone.0279307",
      "doi_url": "https://doi.org/10.1371/journal.pone.0279307",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36538554/",
      "url": "https://h2medicine.org/studies/study-valenta-2022-pre-exercise-maximal-aerobic-speed-runners/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "36235628",
      "year": 2022,
      "title": "The Acute Effects of a Single Dose of Molecular Hydrogen Supplements on Responses to Ergogenic Adjustments during High-Intensity Intermittent Exercise in Humans",
      "title_en": null,
      "title_de": "Die akuten Effekte einer Einzeldosis molekularer Wasserstoff-Supplemente auf die Reaktionen ergogener Anpassungen während hochintensiver intermittierender Belastung beim Menschen",
      "journal": "Nutrients",
      "authors": "Alharbi et al.",
      "author_search": "alharbi alharbi",
      "doi": "10.3390/nu14193974",
      "doi_url": "https://doi.org/10.3390/nu14193974",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36235628/",
      "url": "https://h2medicine.org/studies/study-alharbi-2022-single-dose-ergogenic-intermittent-exercise/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "oxidative-stress"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "36432562",
      "year": 2022,
      "title": "Effects of Intestinal Bacterial Hydrogen Gas Production on Muscle Recovery following Intense Exercise in Adult Men: A Pilot Study",
      "title_en": null,
      "title_de": "Effekte der intestinalen bakteriellen Wasserstoffgas-Produktion auf die Muskelerholung nach intensiver Belastung bei erwachsenen Männern: eine Pilotstudie",
      "journal": "Nutrients",
      "authors": "Eda et al.",
      "author_search": "eda eda",
      "doi": "10.3390/nu14224875",
      "doi_url": "https://doi.org/10.3390/nu14224875",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36432562/",
      "url": "https://h2medicine.org/studies/study-eda-2022-intestinal-bacterial-gas-muscle-recovery/",
      "methods": [],
      "indications": [
        "sports-exercise",
        "oxidative-stress"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": false,
      "h2category": "byproduct"
    },
    {
      "pmid": "36743938",
      "year": 2022,
      "title": "Effectiveness and safety of hydrogen inhalation as an adjunct treatment in Chinese type 2 diabetes patients: A retrospective, observational, double-arm, real-life clinical study.",
      "title_en": null,
      "title_de": "Wirksamkeit und Sicherheit der Wasserstoff-Inhalation als Zusatzbehandlung bei chinesischen Typ-2-Diabetes-Patienten: eine retrospektive, beobachtende, zweiarmige Real-Life-Studie",
      "journal": "Frontiers in Endocrinology",
      "authors": "Zhao et al.",
      "author_search": "zhao zhao",
      "doi": "10.3389/fendo.2022.1114221",
      "doi_url": "https://doi.org/10.3389/fendo.2022.1114221",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36743938/",
      "url": "https://h2medicine.org/studies/study-zhao-2022-inhalation-type-2-diabetes-adjunct/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "diabetes",
        "metabolic",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "36334558",
      "year": 2022,
      "title": "Research on red tide short-time prediction using GRU network model based on multi-feature Factors--A case in Xiamen sea area.",
      "title_en": null,
      "title_de": "Kurzzeitvorhersage von Rote-Tide-Ereignissen mittels GRU-Netzwerkmodell auf Basis von Multi-Merkmal-Faktoren — Fallstudie im Seegebiet Xiamen",
      "journal": "Marine environmental research",
      "authors": "Xiao et al.",
      "author_search": "xiao xiao",
      "doi": "10.1016/j.marenvres.2022.105727",
      "doi_url": "https://doi.org/10.1016/j.marenvres.2022.105727",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36334558/",
      "url": "https://h2medicine.org/studies/study-xiao-2022-research-red-tide-short/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "fundamentals-safety"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "36239123",
      "year": 2022,
      "title": "A bio-inspired, ultra-tough, high-sensitivity, and anti-swelling conductive hydrogel strain sensor for motion detection and information transmission.",
      "title_en": null,
      "title_de": "Bioinspirierter, ultrazäher, hochempfindlicher und quellungsresistenter leitfähiger Hydrogel-Dehnungssensor für Bewegungserkennung und Informationsübertragung",
      "journal": "Materials horizons",
      "authors": "Di et al.",
      "author_search": "di di",
      "doi": "10.1039/d2mh00456a",
      "doi_url": "https://doi.org/10.1039/d2mh00456a",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36239123/",
      "url": "https://h2medicine.org/studies/study-di-2022-bio-inspired-ultra-tough/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "36210415",
      "year": 2022,
      "title": "Dynamics of Metabolic and Oxidative Parameters of Erythrocytes during Treatment of Chronic Heart Failure with Molecular Hydrogen.",
      "title_en": null,
      "title_de": "Dynamik metabolischer und oxidativer Parameter von Erythrozyten während der Behandlung der chronischen Herzinsuffizienz mit molekularem Wasserstoff.",
      "journal": "Bulletin of experimental biology and medicine",
      "authors": "Deryugina et al.",
      "author_search": "deryugina deryugina",
      "doi": "10.1007/s10517-022-05595-z",
      "doi_url": "https://doi.org/10.1007/s10517-022-05595-z",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36210415/",
      "url": "https://h2medicine.org/studies/study-deryugina-2022-dynamics-metabolic-oxidative-parameters/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cardiovascular",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "36190308",
      "year": 2022,
      "title": "Using a high-throughput, whole-cell hydrogenase assay to identify potential small molecule inhibitors of [NiFe]-hydrogenase.",
      "title_en": null,
      "title_de": "Verwendung eines Hochdurchsatz-Ganzzell-Hydrogenase-Assays zur Identifizierung potenzieller niedermolekularer Inhibitoren der [NiFe]-Hydrogenase",
      "journal": "Metallomics : integrated biometal science",
      "authors": "Sebastiampillai et al.",
      "author_search": "sebastiampillai sebastiampillai",
      "doi": "10.1093/mtomcs/mfac073",
      "doi_url": "https://doi.org/10.1093/mtomcs/mfac073",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36190308/",
      "url": "https://h2medicine.org/studies/study-sebastiampillai-2022-high-throughput-whole-cell/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "36167814",
      "year": 2022,
      "title": "Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing.",
      "title_en": null,
      "title_de": "Photokatalytische Glukosedepletion und Wasserstofferzeugung zur diabetischen Wundheilung",
      "journal": "Nature communications",
      "authors": "Chen et al.",
      "author_search": "chen chen",
      "doi": "10.1038/s41467-022-33475-7",
      "doi_url": "https://doi.org/10.1038/s41467-022-33475-7",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36167814/",
      "url": "https://h2medicine.org/studies/study-chen-2022-photocatalytic-glucose-depletion-generation/",
      "methods": [
        "bath-topical",
        "drinking-hrw"
      ],
      "indications": [
        "diabetes",
        "skin-aging",
        "joints-rheumatology",
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "36014314",
      "year": 2022,
      "title": "Dehydrochlorination of PCDDs on SWCN-Supported Ni10 and Ni13 Clusters, a DFT Study.",
      "title_en": null,
      "title_de": "Dehydrochlorierung von PCDDs an SWCN-getragenen Ni₁₀- und Ni₁₃-Clustern: Eine DFT-Studie",
      "journal": "Molecules (Basel, Switzerland)",
      "authors": "González et al.",
      "author_search": "gonzález gonzález",
      "doi": "10.3390/molecules27165074",
      "doi_url": "https://doi.org/10.3390/molecules27165074",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36014314/",
      "url": "https://h2medicine.org/studies/study-gonzalez-2022-dehydrochlorination-pcdds-swcn-supported/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "35970006",
      "year": 2022,
      "title": "Hydrogen production from urea in human urine using segregated systems.",
      "title_en": null,
      "title_de": "Wasserstofferzeugung aus Harnstoff im menschlichen Urin unter Verwendung getrennter Systeme",
      "journal": "Water research",
      "authors": "Asiain-Mira et al.",
      "author_search": "asiain-mira asiain-mira",
      "doi": "10.1016/j.watres.2022.118931",
      "doi_url": "https://doi.org/10.1016/j.watres.2022.118931",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35970006/",
      "url": "https://h2medicine.org/studies/study-asiainmira-2022-production-urea-urine-segregated/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "35909288",
      "year": 2022,
      "title": "Narrative on Hydrogen Therapy and its Clinical Applications: Safety and Efficacy.",
      "title_en": null,
      "title_de": "Bericht über die Wasserstofftherapie und ihre klinischen Anwendungen: Sicherheit und Wirksamkeit",
      "journal": "Current pharmaceutical design",
      "authors": "Ahmad et al.",
      "author_search": "ahmad ahmad",
      "doi": "10.2174/1381612828666220728104200",
      "doi_url": "https://doi.org/10.2174/1381612828666220728104200",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35909288/",
      "url": "https://h2medicine.org/studies/study-ahmad-2022-narrative-applications/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "neurology",
        "cardiovascular",
        "respiratory",
        "immune-system",
        "oxidative-stress",
        "fundamentals-safety"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "35843727",
      "year": 2022,
      "title": "A potential clinical application of hydrogen-rich saline in patients with traumatic brain injury.",
      "title_en": null,
      "title_de": "Eine potenzielle klinische Anwendung von wasserstoffreicher Kochsalzlösung bei Patienten mit Schädel-Hirn-Trauma.",
      "journal": "Journal of pediatric surgery",
      "authors": "Benjamin et al.",
      "author_search": "benjamin benjamin",
      "doi": "10.1016/j.jpedsurg.2022.06.007",
      "doi_url": "https://doi.org/10.1016/j.jpedsurg.2022.06.007",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35843727/",
      "url": "https://h2medicine.org/studies/study-benjamin-2022-application-saline-traumatic-brain/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "neurology"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "35705974",
      "year": 2022,
      "title": "Microbial hydrogen \"manufactory\" for enhanced gas therapy and self-activated immunotherapy via reduced immune escape.",
      "title_en": null,
      "title_de": "Mikrobielle Wasserstoff-„Manufaktur” für verbesserte Gastherapie und selbstaktivierte Immuntherapie durch reduziertes Immune Escape",
      "journal": "Journal of nanobiotechnology",
      "authors": "Yan et al.",
      "author_search": "yan yan",
      "doi": "10.1186/s12951-022-01440-7",
      "doi_url": "https://doi.org/10.1186/s12951-022-01440-7",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35705974/",
      "url": "https://h2medicine.org/studies/study-yan-2022-microbial-manufactory-enhanced-self/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "35700582",
      "year": 2022,
      "title": "Hydrogen helps to ameliorate Staphylococcus aureus-induced mastitis in mice.",
      "title_en": null,
      "title_de": "Wasserstoff hilft, die durch Staphylococcus aureus induzierte Mastitis bei Mäusen zu lindern",
      "journal": "International immunopharmacology",
      "authors": "Geng et al.",
      "author_search": "geng geng",
      "doi": "10.1016/j.intimp.2022.108940",
      "doi_url": "https://doi.org/10.1016/j.intimp.2022.108940",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35700582/",
      "url": "https://h2medicine.org/studies/study-geng-2022-helps-ameliorate-staphylococcus-aureus/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "35675761",
      "year": 2022,
      "title": "Hydrogen-Rich Water as a Dietary Activator of Brown Adipose Tissue and UCP1?",
      "title_en": null,
      "title_de": "Wasserstoffreiches Wasser als diätetischer Aktivator von braunem Fettgewebe und UCP1?",
      "journal": "Annals of nutrition & metabolism",
      "authors": "Ostojic",
      "author_search": "ostojic ostojic",
      "doi": "10.1159/000525175",
      "doi_url": "https://doi.org/10.1159/000525175",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35675761/",
      "url": "https://h2medicine.org/studies/study-ostojic-2022-dietary-activator-brown-adipose/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "metabolic"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "35606529",
      "year": 2022,
      "title": "Radiographic features of magnesium-based bioabsorbable screw resorption in paediatric fractures.",
      "title_en": null,
      "title_de": "Radiographische Merkmale der Resorption von magnesiumbasierten bioresorbierbaren Schrauben bei pädiatrischen Frakturen",
      "journal": "Pediatric radiology",
      "authors": "Waelti et al.",
      "author_search": "waelti waelti",
      "doi": "10.1007/s00247-022-05383-x",
      "doi_url": "https://doi.org/10.1007/s00247-022-05383-x",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35606529/",
      "url": "https://h2medicine.org/studies/study-waelti-2022-radiographic-features-magnesium-bioabsorbable/",
      "methods": [],
      "indications": [
        "joints-rheumatology"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "byproduct"
    },
    {
      "pmid": "35605978",
      "year": 2022,
      "title": "Development of a Model System for Gas Cavity Formation Behavior of Magnesium Alloy Implantation.",
      "title_en": null,
      "title_de": "Entwicklung eines Modellsystems für das Verhalten der Gashohlraumbildung bei der Implantation von Magnesiumlegierungen",
      "journal": "ACS biomaterials science & engineering",
      "authors": "Yamamoto et al.",
      "author_search": "yamamoto yamamoto",
      "doi": "10.1021/acsbiomaterials.1c01429",
      "doi_url": "https://doi.org/10.1021/acsbiomaterials.1c01429",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35605978/",
      "url": "https://h2medicine.org/studies/study-yamamoto-2022-development-model-system-cavity/",
      "methods": [
        "inhalation",
        "bath-topical"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "35564808",
      "year": 2022,
      "title": "Short-Term Consumption of Hydrogen-Rich Water Enhances Power Performance and Heart Rate Recovery in Dragon Boat Athletes: Evidence from a Pilot Study.",
      "title_en": null,
      "title_de": "Kurzfristiger Konsum von wasserstoffreichem Wasser verbessert die Kraftleistung und die Herzfrequenzerholung bei Drachenboot-Athleten",
      "journal": "International journal of environmental research and public health",
      "authors": "Dong et al.",
      "author_search": "dong dong",
      "doi": "10.3390/ijerph19095413",
      "doi_url": "https://doi.org/10.3390/ijerph19095413",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35564808/",
      "url": "https://h2medicine.org/studies/study-dong-2022-short-term-consumption-enhances/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "cardiovascular",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "35536023",
      "year": 2022,
      "title": "Metabolic Synergy between Human Symbionts Bacteroides and Methanobrevibacter.",
      "title_en": null,
      "title_de": "Metabolische Synergie zwischen den menschlichen Symbionten Bacteroides und Methanobrevibacter",
      "journal": "Microbiology spectrum",
      "authors": "Catlett et al.",
      "author_search": "catlett catlett",
      "doi": "10.1128/spectrum.01067-22",
      "doi_url": "https://doi.org/10.1128/spectrum.01067-22",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35536023/",
      "url": "https://h2medicine.org/studies/study-catlett-2022-metabolic-synergy-between-symbionts/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "metabolic",
        "sports-exercise"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "35484138",
      "year": 2022,
      "title": "Magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer growth.",
      "title_en": null,
      "title_de": "Magnesium-Galvanikzellen erzeugen Wasserstoff und modulieren die Tumormikroumgebung, um das Krebswachstum zu hemmen",
      "journal": "Nature communications",
      "authors": "Yang et al.",
      "author_search": "yang yang",
      "doi": "10.1038/s41467-022-29938-6",
      "doi_url": "https://doi.org/10.1038/s41467-022-29938-6",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35484138/",
      "url": "https://h2medicine.org/studies/study-yang-2022-magnesium-galvanic-cells-produce/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "35300173",
      "year": 2022,
      "title": "Local Treatment of Hydrogen-Rich Saline Promotes Wound Healing In Vivo by Inhibiting Oxidative Stress via Nrf-2/HO-1 Pathway.",
      "title_en": null,
      "title_de": "Die lokale Behandlung mit wasserstoffreicher Kochsalzlösung fördert die Wundheilung in vivo durch Hemmung des oxidativen Stresses über den Nrf-2/HO-1-Signalweg",
      "journal": "Oxidative medicine and cellular longevity",
      "authors": "Li et al.",
      "author_search": "li li",
      "doi": "10.1155/2022/2949824",
      "doi_url": "https://doi.org/10.1155/2022/2949824",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35300173/",
      "url": "https://h2medicine.org/studies/study-li-2022-local-saline-promotes-wound/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "metabolic",
        "cancer",
        "skin-aging",
        "immune-system",
        "oxidative-stress",
        "fundamentals-safety"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "35273249",
      "year": 2022,
      "title": "Long-term and daily use of molecular hydrogen induces reprogramming of liver metabolism in rats by modulating NADP/NADPH redox pathways.",
      "title_en": null,
      "title_de": "Die langfristige und tägliche Anwendung von molekularem Wasserstoff induziert eine Reprogrammierung des Leberstoffwechsels bei Ratten durch Modulation der NADP/NADPH-Redox-Signalwege",
      "journal": "Scientific reports",
      "authors": "Adzavon et al.",
      "author_search": "adzavon adzavon",
      "doi": "10.1038/s41598-022-07710-6",
      "doi_url": "https://doi.org/10.1038/s41598-022-07710-6",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35273249/",
      "url": "https://h2medicine.org/studies/study-adzavon-2022-long-term-daily-use/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "metabolic",
        "liver",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "35258003",
      "year": 2022,
      "title": "Hydrogen-rich water can reduce the formation of biogenic amines in butter.",
      "title_en": null,
      "title_de": "Wasserstoffreiches Wasser kann die Bildung biogener Amine in Butter reduzieren",
      "journal": "Food chemistry",
      "authors": "Bulut et al.",
      "author_search": "bulut bulut",
      "doi": "10.1016/j.foodchem.2022.132613",
      "doi_url": "https://doi.org/10.1016/j.foodchem.2022.132613",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35258003/",
      "url": "https://h2medicine.org/studies/study-bulut-2022-can-reduce-formation-biogenic/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "35187885",
      "year": 2022,
      "title": "Molecular hydrogen is a promising therapeutic agent for pulmonary disease.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff ist ein vielversprechendes Therapeutikum für Lungenerkrankungen",
      "journal": "Journal of Zhejiang University. Science. B",
      "authors": "Fu et al.",
      "author_search": "fu fu",
      "doi": "10.1631/jzus.b2100420",
      "doi_url": "https://doi.org/10.1631/jzus.b2100420",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35187885/",
      "url": "https://h2medicine.org/studies/study-fu-2022-promising-therapeutic-agent-pulmonary/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cardiovascular",
        "cancer",
        "respiratory",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "35075943",
      "year": 2022,
      "title": "Quantification of dissolved H2 and continuous monitoring of hydrogen-rich water for haemodialysis applications: An experimental study.",
      "title_en": null,
      "title_de": "Quantifizierung von gelöstem H₂ und kontinuierliche Überwachung von wasserstoffreichem Wasser für Hämodialyseanwendungen: Eine experimentelle Studie",
      "journal": "The International journal of artificial organs",
      "authors": "Mouzakis et al.",
      "author_search": "mouzakis mouzakis",
      "doi": "10.1177/03913988211070588",
      "doi_url": "https://doi.org/10.1177/03913988211070588",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35075943/",
      "url": "https://h2medicine.org/studies/study-mouzakis-2022-quantification-dissolved-continuous-monitoring/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "kidney-dialysis",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "35025709",
      "year": 2022,
      "title": "Microbial hydrogen economy alleviates colitis by reprogramming colonocyte metabolism and reinforcing intestinal barrier.",
      "title_en": null,
      "title_de": "Die mikrobielle Wasserstoffökonomie lindert Kolitis durch Reprogrammierung des Kolonozytenstoffwechsels und Stärkung der Darmbarriere",
      "journal": "Gut microbes",
      "authors": "Ge et al.",
      "author_search": "ge ge",
      "doi": "10.1080/19490976.2021.2013764",
      "doi_url": "https://doi.org/10.1080/19490976.2021.2013764",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35025709/",
      "url": "https://h2medicine.org/studies/study-ge-2022-microbial-economy-alleviates-colitis/",
      "methods": [
        "inhalation",
        "saline-iv"
      ],
      "indications": [
        "metabolic",
        "sports-exercise",
        "immune-system",
        "oxidative-stress",
        "fundamentals-safety"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "34995727",
      "year": 2022,
      "title": "Gender-based differences in neuroprotective effects of hydrogen gas against intracerebral hemorrhage-induced depression.",
      "title_en": null,
      "title_de": "Geschlechtsspezifische Unterschiede in den neuroprotektiven Wirkungen von Wasserstoffgas gegen durch intrazerebrale Blutung induzierte Depression",
      "journal": "Neurochemistry international",
      "authors": "An et al.",
      "author_search": "an an",
      "doi": "10.1016/j.neuint.2022.105276",
      "doi_url": "https://doi.org/10.1016/j.neuint.2022.105276",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34995727/",
      "url": "https://h2medicine.org/studies/study-an-2022-gender-differences-neuroprotective-against/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "neurology",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "34854421",
      "year": 2022,
      "title": "In vivo microelectrode monitoring of real-time hydrogen concentration in different tissues of rats after inhaling hydrogen gas.",
      "title_en": null,
      "title_de": "In-vivo-Mikroelektroden-Überwachung der Echtzeit-Wasserstoffkonzentration in verschiedenen Geweben von Ratten nach Inhalation von Wasserstoffgas",
      "journal": "Medical gas research",
      "authors": "Liu et al.",
      "author_search": "liu liu",
      "doi": "10.4103/2045-9912.330694",
      "doi_url": "https://doi.org/10.4103/2045-9912.330694",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34854421/",
      "url": "https://h2medicine.org/studies/study-liu-2022-vivo-microelectrode-monitoring-real/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "metabolic",
        "liver",
        "sports-exercise",
        "neurology",
        "kidney-dialysis"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "34854419",
      "year": 2022,
      "title": "Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity based on oxygen radical absorbing and inflammation levels in human serum.",
      "title_en": null,
      "title_de": "Wasserstoffreiches Bad mit nanogroßen Bläschen verbessert die antioxidative Kapazität und die Entzündungswerte im menschlichen Serum",
      "journal": "Medical gas research",
      "authors": "Tanaka et al.",
      "author_search": "tanaka tanaka",
      "doi": "10.4103/2045-9912.330692",
      "doi_url": "https://doi.org/10.4103/2045-9912.330692",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34854419/",
      "url": "https://h2medicine.org/studies/study-tanaka-2022-bath-nano-sized-bubbles/",
      "methods": [
        "bath-topical"
      ],
      "indications": [
        "skin-aging",
        "immune-system",
        "oxidative-stress",
        "fundamentals-safety"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "34655499",
      "year": 2022,
      "title": "Metal-Organic-Framework-Based Hydrogen-Release Platform for Multieffective Helicobacter Pylori Targeting Therapy and Intestinal Flora Protective Capabilities.",
      "title_en": null,
      "title_de": "Metallorganische-Gerüstverbindungs-basierte Wasserstofffreisetzungsplattform für eine multieffektive zielgerichtete Helicobacter-pylori-Therapie und intestinale-Flora-schützende Fähigkeiten",
      "journal": "Advanced materials (Deerfield Beach, Fla.)",
      "authors": "Zhang et al.",
      "author_search": "zhang zhang",
      "doi": "10.1002/adma.202105738",
      "doi_url": "https://doi.org/10.1002/adma.202105738",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34655499/",
      "url": "https://h2medicine.org/studies/study-zhang-2022-metal-organic-framework-release/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "34583156",
      "year": 2022,
      "title": "Regulation of chlorothalonil degradation by molecular hydrogen.",
      "title_en": null,
      "title_de": "Regulation des Chlorothalonil-Abbaus durch molekularen Wasserstoff",
      "journal": "Journal of hazardous materials",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1016/j.jhazmat.2021.127291",
      "doi_url": "https://doi.org/10.1016/j.jhazmat.2021.127291",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34583156/",
      "url": "https://h2medicine.org/studies/study-wang-2022-regulation-chlorothalonil-degradation/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "34533646",
      "year": 2022,
      "title": "Molecular hydrogen suppresses Porphyromonas gingivalis lipopolysaccharide-induced increases in interleukin-1 alpha and interleukin-6 secretion in human gingival cells.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff unterdrückt die durch Porphyromonas-gingivalis-Lipopolysaccharid induzierte Erhöhung der Interleukin-1-alpha- und Interleukin-6-Sekretion in menschlichen Zahnfleischzellen.",
      "journal": "Molecular and cellular biochemistry",
      "authors": "Saitoh et al.",
      "author_search": "saitoh saitoh",
      "doi": "10.1007/s11010-021-04262-7",
      "doi_url": "https://doi.org/10.1007/s11010-021-04262-7",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34533646/",
      "url": "https://h2medicine.org/studies/study-saitoh-2022-suppresses-porphyromonas-gingivalis-lipopolysaccharide/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "immune-system",
        "oral-health",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "34365467",
      "year": 2022,
      "title": "Hydrogen-rich water reduced oxidative stress and renal fibrosis in rats with unilateral ureteral obstruction.",
      "title_en": null,
      "title_de": "Wasserstoffreiches Wasser reduzierte oxidativen Stress und renale Fibrose bei Ratten mit einseitiger Ureterobstruktion.",
      "journal": "Pediatric research",
      "authors": "Mizutani et al.",
      "author_search": "mizutani mizutani",
      "doi": "10.1038/s41390-021-01648-7",
      "doi_url": "https://doi.org/10.1038/s41390-021-01648-7",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34365467/",
      "url": "https://h2medicine.org/studies/study-mizutani-2022-reduced-oxidative-stress-renal/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "kidney-dialysis",
        "skin-aging",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "36115583",
      "year": 2022,
      "title": "Molecular hydrogen has a positive impact on pregnancy maintenance through enhancement of mitochondrial function and immunomodulatory effects on T cells",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff hat durch die Verbesserung der Mitochondrienfunktion und immunmodulatorische Effekte auf T-Zellen einen positiven Einfluss auf den Schwangerschaftserhalt",
      "journal": "Life Sciences",
      "authors": "Aoki et al.",
      "author_search": "aoki aoki",
      "doi": "10.1016/j.lfs.2022.120955",
      "doi_url": "https://doi.org/10.1016/j.lfs.2022.120955",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36115583/",
      "url": "https://h2medicine.org/studies/study-aoki-2022-pregnancy-maintenance-mitochondrial-t-cells/",
      "methods": [],
      "indications": [
        "pregnancy",
        "womens-health",
        "immune-system",
        "mechanism"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "32912119",
      "year": 2021,
      "title": "Perspective of Molecular Hydrogen in the Treatment of Sepsis",
      "title_en": null,
      "title_de": "Perspektive des molekularen Wasserstoffs in der Behandlung der Sepsis",
      "journal": "Current Pharmaceutical Design",
      "authors": "Qi et al.",
      "author_search": "qi qi",
      "doi": "10.2174/1381612826666200909124936",
      "doi_url": "https://doi.org/10.2174/1381612826666200909124936",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32912119/",
      "url": "https://h2medicine.org/studies/study-qi-2021-sepsis-treatment/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "fundamentals",
        "oxidative-stress",
        "respiratory"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "33076798",
      "year": 2021,
      "title": "Neuroprotective and Preventative Effects of Molecular Hydrogen",
      "title_en": null,
      "title_de": "Neuroprotektive und präventive Effekte des molekularen Wasserstoffs",
      "journal": "Current Pharmaceutical Design",
      "authors": "Noda et al.",
      "author_search": "noda noda",
      "doi": "10.2174/1381612826666201019103020",
      "doi_url": "https://doi.org/10.2174/1381612826666201019103020",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33076798/",
      "url": "https://h2medicine.org/studies/study-noda-2021-neuroprotective-preventative/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "neurology",
        "oxidative-stress",
        "fundamentals"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "34717628",
      "year": 2021,
      "title": "Cell surface sphingomyelin: key role in cancer initiation, progression, and immune evasion.",
      "title_en": null,
      "title_de": "Sphingomyelin der Zelloberfläche: Schlüsselrolle bei Krebsentstehung, -progression und Immunevasion.",
      "journal": "Lipids in health and disease",
      "authors": "Tallima et al.",
      "author_search": "tallima tallima",
      "doi": "10.1186/s12944-021-01581-y",
      "doi_url": "https://doi.org/10.1186/s12944-021-01581-y",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34717628/",
      "url": "https://h2medicine.org/studies/study-tallima-2021-cell-surface-sphingomyelin-key/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "immune-system"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "34646423",
      "year": 2021,
      "title": "Combating Oxidative Stress and Inflammation in COVID-19 by Molecular Hydrogen Therapy: Mechanisms and Perspectives.",
      "title_en": null,
      "title_de": "Bekämpfung von oxidativem Stress und Entzündung bei COVID-19 durch molekulare Wasserstofftherapie: Mechanismen und Perspektiven.",
      "journal": "Oxidative medicine and cellular longevity",
      "authors": "Alwazeer et al.",
      "author_search": "alwazeer alwazeer",
      "doi": "10.1155/2021/5513868",
      "doi_url": "https://doi.org/10.1155/2021/5513868",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34646423/",
      "url": "https://h2medicine.org/studies/study-alwazeer-2021-combating-oxidative-stress-inflammation/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "respiratory",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "34643743",
      "year": 2021,
      "title": "Amyloid β structural polymorphism, associated toxicity and therapeutic strategies.",
      "title_en": null,
      "title_de": "Strukturelle Polymorphie von Amyloid β, assoziierte Toxizität und therapeutische Strategien.",
      "journal": "Cellular and molecular life sciences : CMLS",
      "authors": "Oren et al.",
      "author_search": "oren oren",
      "doi": "10.1007/s00018-021-03954-z",
      "doi_url": "https://doi.org/10.1007/s00018-021-03954-z",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34643743/",
      "url": "https://h2medicine.org/studies/study-oren-2021-amyloid-structural-polymorphism-associated/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "metabolic",
        "sports-exercise",
        "neurology"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "34538034",
      "year": 2021,
      "title": "[Intestinal microbiote of athletes].",
      "title_en": null,
      "title_de": "Darmmikrobiota von Sportlern.",
      "journal": "Voprosy pitaniia",
      "authors": "Bragina et al.",
      "author_search": "bragina bragina",
      "doi": "10.33029/0042-8833-2021-90-4-36-52",
      "doi_url": "https://doi.org/10.33029/0042-8833-2021-90-4-36-52",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34538034/",
      "url": "https://h2medicine.org/studies/study-bragina-2021-intestinal-microbiote-athletes/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "cardiovascular",
        "respiratory",
        "eye"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "34445428",
      "year": 2021,
      "title": "Molecular Hydrogen as a Novel Antitumor Agent: Possible Mechanisms Underlying Gene Expression.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff als neuartiges Antitumormittel: Mögliche zugrunde liegende Mechanismen der Genexpression.",
      "journal": "International journal of molecular sciences",
      "authors": "Hirano et al.",
      "author_search": "hirano hirano",
      "doi": "10.3390/ijms22168724",
      "doi_url": "https://doi.org/10.3390/ijms22168724",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34445428/",
      "url": "https://h2medicine.org/studies/study-hirano-2021-antitumor-agent-possible-mechanisms/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "immune-system",
        "oxidative-stress",
        "fundamentals-safety"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "34281264",
      "year": 2021,
      "title": "Molecular Hydrogen as a Novel Protective Agent against Pre-Symptomatic Diseases.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff als neuartiges Schutzmittel gegen präsymptomatische Erkrankungen.",
      "journal": "International journal of molecular sciences",
      "authors": "Yamamoto et al.",
      "author_search": "yamamoto yamamoto",
      "doi": "10.3390/ijms22137211",
      "doi_url": "https://doi.org/10.3390/ijms22137211",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34281264/",
      "url": "https://h2medicine.org/studies/study-yamamoto-2021-protective-agent-against-pre/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "33945834",
      "year": 2021,
      "title": "How the brain fights fatty acids' toxicity.",
      "title_en": null,
      "title_de": "Wie das Gehirn die Toxizität von Fettsäuren bekämpft.",
      "journal": "Neurochemistry international",
      "authors": "Schönfeld et al.",
      "author_search": "schönfeld schönfeld",
      "doi": "10.1016/j.neuint.2021.105050",
      "doi_url": "https://doi.org/10.1016/j.neuint.2021.105050",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33945834/",
      "url": "https://h2medicine.org/studies/study-schoenfeld-2021-how-brain-fights-fatty/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "metabolic",
        "neurology",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "33925430",
      "year": 2021,
      "title": "Molecular Hydrogen as a Potential Clinically Applicable Radioprotective Agent.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff als potenziell klinisch anwendbares Radioprotektivum.",
      "journal": "International journal of molecular sciences",
      "authors": "Hirano et al.",
      "author_search": "hirano hirano",
      "doi": "10.3390/ijms22094566",
      "doi_url": "https://doi.org/10.3390/ijms22094566",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33925430/",
      "url": "https://h2medicine.org/studies/study-hirano-2021-clinically-applicable-radioprotective-agent/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "33899545",
      "year": 2021,
      "title": "Protective effects of molecular hydrogen on lung injury from lung transplantation.",
      "title_en": null,
      "title_de": "Schützende Wirkungen von molekularem Wasserstoff auf Lungenschäden bei Lungentransplantation.",
      "journal": "Experimental biology and medicine (Maywood, N.J.)",
      "authors": "Quan et al.",
      "author_search": "quan quan",
      "doi": "10.1177/15353702211007084",
      "doi_url": "https://doi.org/10.1177/15353702211007084",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33899545/",
      "url": "https://h2medicine.org/studies/study-quan-2021-protective-lung-injury-lung/",
      "methods": [
        "inhalation",
        "saline-iv",
        "bath-topical",
        "drinking-hrw"
      ],
      "indications": [
        "respiratory",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "33806292",
      "year": 2021,
      "title": "Potential Therapeutic Applications of Hydrogen in Chronic Inflammatory Diseases: Possible Inhibiting Role on Mitochondrial Stress.",
      "title_en": null,
      "title_de": "Mögliche therapeutische Anwendungen von Wasserstoff bei chronisch-entzündlichen Erkrankungen: Mögliche hemmende Rolle bei mitochondrialem Stress.",
      "journal": "International journal of molecular sciences",
      "authors": "Hirano et al.",
      "author_search": "hirano hirano",
      "doi": "10.3390/ijms22052549",
      "doi_url": "https://doi.org/10.3390/ijms22052549",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33806292/",
      "url": "https://h2medicine.org/studies/study-hirano-2021-therapeutic-applications-chronic-inflammatory/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "respiratory",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "33769417",
      "year": 2021,
      "title": "Inhaled gases as novel neuroprotective therapies in the postcardiac arrest period.",
      "title_en": null,
      "title_de": "Inhalierte Gase als neuartige neuroprotektive Therapien in der Phase nach Herzstillstand.",
      "journal": "Current opinion in critical care",
      "authors": "Magliocca et al.",
      "author_search": "magliocca magliocca",
      "doi": "10.1097/mcc.0000000000000820",
      "doi_url": "https://doi.org/10.1097/mcc.0000000000000820",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33769417/",
      "url": "https://h2medicine.org/studies/study-magliocca-2021-inhaled-gases-neuroprotective-therapies/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "neurology",
        "fundamentals-safety"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "33762390",
      "year": 2021,
      "title": "Hydrogen treatment: a novel option in liver diseases.",
      "title_en": null,
      "title_de": "Wasserstoffbehandlung: eine neuartige Option bei Lebererkrankungen.",
      "journal": "Clinical medicine (London, England)",
      "authors": "Shi et al.",
      "author_search": "shi shi",
      "doi": "10.7861/clinmed.2020-0370",
      "doi_url": "https://doi.org/10.7861/clinmed.2020-0370",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33762390/",
      "url": "https://h2medicine.org/studies/study-shi-2021-option-liver-diseases/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver",
        "sports-exercise",
        "cancer",
        "immune-system",
        "oxidative-stress",
        "fundamentals-safety"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "33719401",
      "year": 2021,
      "title": "Chemical and Biochemical Aspects of Molecular Hydrogen in Treating Kawasaki Disease and COVID-19.",
      "title_en": null,
      "title_de": "Chemische und biochemische Aspekte von molekularem Wasserstoff bei der Behandlung des Kawasaki-Syndroms und von COVID-19.",
      "journal": "Chemical research in toxicology",
      "authors": "Chen et al.",
      "author_search": "chen chen",
      "doi": "10.1021/acs.chemrestox.0c00456",
      "doi_url": "https://doi.org/10.1021/acs.chemrestox.0c00456",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33719401/",
      "url": "https://h2medicine.org/studies/study-chen-2021-chemical-biochemical-aspects-treating/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cardiovascular",
        "respiratory",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "33510842",
      "year": 2021,
      "title": "Hydrogen Gas: A Novel Type of Antioxidant in Modulating Sexual Organs Homeostasis.",
      "title_en": null,
      "title_de": "Wasserstoffgas: Ein neuartiger Typ von Antioxidans bei der Modulation der Homöostase der Geschlechtsorgane.",
      "journal": "Oxidative medicine and cellular longevity",
      "authors": "Zhang et al.",
      "author_search": "zhang zhang",
      "doi": "10.1155/2021/8844346",
      "doi_url": "https://doi.org/10.1155/2021/8844346",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33510842/",
      "url": "https://h2medicine.org/studies/study-zhang-2021-type-antioxidant-modulating-sexual/",
      "methods": [
        "inhalation",
        "bath-topical"
      ],
      "indications": [
        "cancer",
        "immune-system",
        "womens-health",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "33349213",
      "year": 2021,
      "title": "Hydrogen Gas Therapy: From Preclinical Studies to Clinical Trials.",
      "title_en": null,
      "title_de": "Wasserstoffgas-Therapie: Von präklinischen Studien zu klinischen Studien.",
      "journal": "Current pharmaceutical design",
      "authors": "Sano et al.",
      "author_search": "sano sano",
      "doi": "10.2174/1381612826666201221150857",
      "doi_url": "https://doi.org/10.2174/1381612826666201221150857",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33349213/",
      "url": "https://h2medicine.org/studies/study-sano-2021-preclinical-trials/",
      "methods": [
        "inhalation",
        "saline-iv"
      ],
      "indications": [
        "sports-exercise",
        "cardiovascular",
        "cancer",
        "respiratory",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "33290194",
      "year": 2021,
      "title": "Hydrogen Commonly Applicable from Medicine to Agriculture: From Molecular Mechanisms to the Field.",
      "title_en": null,
      "title_de": "Wasserstoff – allgemein anwendbar von der Medizin bis zur Landwirtschaft: Von molekularen Mechanismen bis zur Praxis.",
      "journal": "Current pharmaceutical design",
      "authors": "Li et al.",
      "author_search": "li li",
      "doi": "10.2174/1381612826666201207220051",
      "doi_url": "https://doi.org/10.2174/1381612826666201207220051",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33290194/",
      "url": "https://h2medicine.org/studies/study-li-2021-commonly-applicable-medicine-agriculture/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "fundamentals-safety"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "33185158",
      "year": 2021,
      "title": "Hydrogen-induced Neuroprotection in Neonatal Hypoxic-ischemic Encephalopathy.",
      "title_en": null,
      "title_de": "Wasserstoffinduzierte Neuroprotektion bei neonataler hypoxisch-ischämischer Enzephalopathie.",
      "journal": "Current pharmaceutical design",
      "authors": "Domoki",
      "author_search": "domoki domoki",
      "doi": "10.2174/1381612826666201113095720",
      "doi_url": "https://doi.org/10.2174/1381612826666201113095720",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33185158/",
      "url": "https://h2medicine.org/studies/study-domoki-2021-induced-neuroprotection-neonatal-hypoxic/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "neurology",
        "cardiovascular",
        "immune-system",
        "oxidative-stress",
        "fundamentals-safety"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "33185152",
      "year": 2021,
      "title": "Recent Advances in Molecular Hydrogen Research Reducing Exercise-Induced Oxidative Stress and Inflammation.",
      "title_en": null,
      "title_de": "Aktuelle Fortschritte in der Forschung zu molekularem Wasserstoff zur Reduktion von belastungsinduziertem oxidativem Stress und Entzündung.",
      "journal": "Current pharmaceutical design",
      "authors": "Nogueira et al.",
      "author_search": "nogueira nogueira",
      "doi": "10.2174/1381612826666201113100245",
      "doi_url": "https://doi.org/10.2174/1381612826666201113100245",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33185152/",
      "url": "https://h2medicine.org/studies/study-nogueira-2021-recent-advances-research-reducing/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "33183204",
      "year": 2021,
      "title": "An Overview of Ovarian Cancer: Molecular Processes Involved and Development of Target-based Chemotherapeutics.",
      "title_en": null,
      "title_de": "Ein Überblick über Ovarialkarzinom: Beteiligte molekulare Prozesse und Entwicklung zielgerichteter Chemotherapeutika.",
      "journal": "Current topics in medicinal chemistry",
      "authors": "Shaik et al.",
      "author_search": "shaik shaik",
      "doi": "10.2174/1568026620999201111155426",
      "doi_url": "https://doi.org/10.2174/1568026620999201111155426",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33183204/",
      "url": "https://h2medicine.org/studies/study-shaik-2021-overview-ovarian-cancer-processes/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "womens-health"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "33148420",
      "year": 2021,
      "title": "Recent advances in studies of molecular hydrogen in the treatment of pancreatitis.",
      "title_en": null,
      "title_de": "Aktuelle Fortschritte in Studien zu molekularem Wasserstoff bei der Behandlung der Pankreatitis.",
      "journal": "Life sciences",
      "authors": "Li et al.",
      "author_search": "li li",
      "doi": "10.1016/j.lfs.2020.118641",
      "doi_url": "https://doi.org/10.1016/j.lfs.2020.118641",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33148420/",
      "url": "https://h2medicine.org/studies/study-li-2021-recent-advances-pancreatitis/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "33078374",
      "year": 2021,
      "title": "Neuroprotective Effects of Molecular Hydrogen: A Critical Review.",
      "title_en": null,
      "title_de": "Neuroprotektive Wirkungen von molekularem Wasserstoff: Eine kritische Übersichtsarbeit.",
      "journal": "Neuroscience bulletin",
      "authors": "Chen et al.",
      "author_search": "chen chen",
      "doi": "10.1007/s12264-020-00597-1",
      "doi_url": "https://doi.org/10.1007/s12264-020-00597-1",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33078374/",
      "url": "https://h2medicine.org/studies/study-chen-2021-neuroprotective-critical-review/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "neurology",
        "immune-system",
        "fundamentals-safety"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "32981497",
      "year": 2021,
      "title": "Role of Molecular Hydrogen in Skin Diseases and its Impact in Beauty.",
      "title_en": null,
      "title_de": "Die Rolle von molekularem Wasserstoff bei Hauterkrankungen und seine Auswirkung auf die Schönheit.",
      "journal": "Current pharmaceutical design",
      "authors": "Bajgai et al.",
      "author_search": "bajgai bajgai",
      "doi": "10.2174/1381612826666200925124235",
      "doi_url": "https://doi.org/10.2174/1381612826666200925124235",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32981497/",
      "url": "https://h2medicine.org/studies/study-bajgai-2021-skin-diseases-impact-beauty/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise",
        "skin-aging",
        "immune-system",
        "allergy",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "32767925",
      "year": 2021,
      "title": "Direct Targets and Subsequent Pathways for Molecular Hydrogen to Exert Multiple Functions: Focusing on Interventions in Radical Reactions.",
      "title_en": null,
      "title_de": "Direkte Zielstrukturen und nachgeschaltete Signalwege, über die molekularer Wasserstoff vielfältige Funktionen ausübt: Mit Fokus auf Eingriffe in Radikalreaktionen",
      "journal": "Current pharmaceutical design",
      "authors": "Ohta",
      "author_search": "ohta ohta",
      "doi": "10.2174/1381612826666200806101137",
      "doi_url": "https://doi.org/10.2174/1381612826666200806101137",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32767925/",
      "url": "https://h2medicine.org/studies/study-ohta-2021-direct-targets-subsequent-pathways/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "metabolic",
        "neurology",
        "cancer",
        "respiratory",
        "immune-system",
        "allergy",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "32505123",
      "year": 2021,
      "title": "Hydrogen and therapeutic gases for neonatal hypoxic-ischemic encephalopathy: potential neuroprotective adjuncts in translational research.",
      "title_en": null,
      "title_de": "Wasserstoff und therapeutische Gase bei neonataler hypoxisch-ischämischer Enzephalopathie: potenzielle neuroprotektive Zusatztherapien in der translationalen Forschung",
      "journal": "Pediatric research",
      "authors": "Htun et al.",
      "author_search": "htun htun",
      "doi": "10.1038/s41390-020-0998-z",
      "doi_url": "https://doi.org/10.1038/s41390-020-0998-z",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32505123/",
      "url": "https://h2medicine.org/studies/study-htun-2021-therapeutic-gases-neonatal-hypoxic/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "neurology",
        "oxidative-stress",
        "fundamentals-safety"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "33356580",
      "year": 2021,
      "title": "Hydrotherapy with hydrogen-rich water compared with RICE protocol following acute ankle sprain in professional athletes: a randomized non-inferiority pilot trial",
      "title_en": null,
      "title_de": "Hydrotherapie mit wasserstoffreichem Wasser im Vergleich zum RICE-Protokoll nach akuter Knöchelverstauchung bei Profisportlern: eine randomisierte Nicht-Unterlegenheits-Pilotstudie",
      "journal": "Research in Sports Medicine",
      "authors": "Javorac et al.",
      "author_search": "javorac javorac",
      "doi": "10.1080/15438627.2020.1868468",
      "doi_url": "https://doi.org/10.1080/15438627.2020.1868468",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33356580/",
      "url": "https://h2medicine.org/studies/study-javorac-2021-ankle-sprain-rice-protocol-athletes/",
      "methods": [
        "bath-topical",
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "joints-rheumatology",
        "oxidative-stress"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "33573133",
      "year": 2021,
      "title": "Application of Molecular Hydrogen as an Antioxidant in Responses to Ventilatory and Ergogenic Adjustments during Incremental Exercise in Humans",
      "title_en": null,
      "title_de": "Anwendung von molekularem Wasserstoff als Antioxidans bei den Reaktionen von Atmung und ergogenen Anpassungen während stufenweiser Belastung beim Menschen",
      "journal": "Nutrients",
      "authors": "Alharbi et al.",
      "author_search": "alharbi alharbi",
      "doi": "10.3390/nu13020459",
      "doi_url": "https://doi.org/10.3390/nu13020459",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33573133/",
      "url": "https://h2medicine.org/studies/study-alharbi-2021-antioxidant-ventilatory-ergogenic-incremental-exercise/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "oxidative-stress"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "34319514",
      "year": 2021,
      "title": "Randomized double-blind placebo-controlled trial of hydrogen inhalation for Parkinson's disease: a pilot study",
      "title_en": null,
      "title_de": "Randomisierte doppelblinde placebokontrollierte Studie zur Wasserstoff-Inhalation bei der Parkinson-Krankheit: eine Pilotstudie",
      "journal": "Neurological Sciences",
      "authors": "Yoritaka et al.",
      "author_search": "yoritaka yoritaka",
      "doi": "10.1007/s10072-021-05489-4",
      "doi_url": "https://doi.org/10.1007/s10072-021-05489-4",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34319514/",
      "url": "https://h2medicine.org/studies/study-yoritaka-2021-inhalation-parkinson-disease/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "neurology",
        "oxidative-stress"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "33349011",
      "year": 2021,
      "title": "Intravenous Hydrogen Therapy With Intracisternal Magnesium Sulfate Infusion in Severe Aneurysmal Subarachnoid Hemorrhage.",
      "title_en": null,
      "title_de": "Intravenöse Wasserstofftherapie mit intrazisternaler Magnesiumsulfat-Infusion bei schwerer aneurysmatischer Subarachnoidalblutung",
      "journal": "Stroke",
      "authors": "Takeuchi et al.",
      "author_search": "takeuchi takeuchi",
      "doi": "10.1161/strokeaha.120.031260",
      "doi_url": "https://doi.org/10.1161/strokeaha.120.031260",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33349011/",
      "url": "https://h2medicine.org/studies/study-takeuchi-2021-intravenous-intracisternal-magnesium-sulfate/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "sports-exercise",
        "neurology"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "33454037",
      "year": 2021,
      "title": "Heat-retention effects of hydrogen-rich water bath assessed by thermography for humans",
      "title_en": null,
      "title_de": "Wärmespeichernde Effekte eines Bades mit wasserstoffreichem Wasser, mittels Thermografie beim Menschen untersucht",
      "journal": "Journal of Thermal Biology",
      "authors": "Kato et al.",
      "author_search": "kato kato",
      "doi": "10.1016/j.jtherbio.2020.102805",
      "doi_url": "https://doi.org/10.1016/j.jtherbio.2020.102805",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33454037/",
      "url": "https://h2medicine.org/studies/study-kato-2021-heat-retention-bath-thermography/",
      "methods": [
        "bath-topical",
        "drinking-hrw"
      ],
      "indications": [
        "skin-aging",
        "cardiovascular",
        "fundamentals"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "33530211",
      "year": 2021,
      "title": "Effects of concomitant use of hydrogen water and photobiomodulation on Parkinson disease: A pilot study",
      "title_en": null,
      "title_de": "Auswirkungen der kombinierten Anwendung von Wasserstoffwasser und Photobiomodulation auf die Parkinson-Krankheit: Eine Pilotstudie",
      "journal": "Medicine",
      "authors": "Hong et al.",
      "author_search": "hong hong",
      "doi": "10.1097/md.0000000000024191",
      "doi_url": "https://doi.org/10.1097/md.0000000000024191",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33530211/",
      "url": "https://h2medicine.org/studies/study-hong-2021-photobiomodulation-parkinson-disease/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "neurology",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "33742060",
      "year": 2021,
      "title": "Randomized, crossover clinical efficacy trial in humans and mice on tear secretion promotion and lacrimal gland protection by molecular hydrogen",
      "title_en": null,
      "title_de": "Randomisierte Crossover-Studie zur klinischen Wirksamkeit an Mensch und Maus zur Förderung der Tränensekretion und zum Schutz der Tränendrüse durch molekularen Wasserstoff",
      "journal": "Scientific Reports",
      "authors": "Kubota et al.",
      "author_search": "kubota kubota",
      "doi": "10.1038/s41598-021-85895-y",
      "doi_url": "https://doi.org/10.1038/s41598-021-85895-y",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33742060/",
      "url": "https://h2medicine.org/studies/study-kubota-2021-tear-secretion-lacrimal-gland/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "eye",
        "oxidative-stress",
        "skin-aging"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "33942780",
      "year": 2021,
      "title": "Protective effects of hydrogen gas inhalation on radiation-induced bone marrow damage in cancer patients: a retrospective observational study",
      "title_en": null,
      "title_de": "Schützende Wirkungen der Wasserstoffgas-Inhalation auf strahleninduzierte Knochenmarkschäden bei Krebspatienten: eine retrospektive Beobachtungsstudie",
      "journal": "Medical Gas Research",
      "authors": "Hirano et al.",
      "author_search": "hirano hirano",
      "doi": "10.4103/2045-9912.314329",
      "doi_url": "https://doi.org/10.4103/2045-9912.314329",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33942780/",
      "url": "https://h2medicine.org/studies/study-hirano-2021-gas-inhalation-radiation-bone-marrow-cancer/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cancer",
        "oxidative-stress",
        "immune-system"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "34601077",
      "year": 2021,
      "title": "The effects of 6-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in older adults aged 70 years and over: A randomized controlled pilot trial",
      "title_en": null,
      "title_de": "Die Wirkungen einer 6-monatigen Einnahme von wasserstoffreichem Wasser auf molekulare und phänotypische Biomarker des Alterns bei älteren Erwachsenen ab 70 Jahren: Eine randomisierte kontrollierte Pilotstudie",
      "journal": "Experimental Gerontology",
      "authors": "Zanini et al.",
      "author_search": "zanini zanini",
      "doi": "10.1016/j.exger.2021.111574",
      "doi_url": "https://doi.org/10.1016/j.exger.2021.111574",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34601077/",
      "url": "https://h2medicine.org/studies/study-zanini-2021-6-month-biomarkers-aging-older-adults/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "skin-aging",
        "neurology",
        "oxidative-stress",
        "metabolic"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "35046230",
      "year": 2021,
      "title": "[ASSOCIATION OF BREATH HYDROGEN CONCENTRATION WITH ORAL INTAKE AND URINARY DISEASES].",
      "title_en": null,
      "title_de": "Zusammenhang der Wasserstoffkonzentration in der Atemluft mit oraler Nahrungsaufnahme und Harnwegserkrankungen",
      "journal": "Nihon Hinyokika Gakkai zasshi. The japanese journal of urology",
      "authors": "Sugaya et al.",
      "author_search": "sugaya sugaya",
      "doi": "10.5980/jpnjurol.112.11",
      "doi_url": "https://doi.org/10.5980/jpnjurol.112.11",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35046230/",
      "url": "https://h2medicine.org/studies/study-sugaya-2021-association-breath-concentration-oral/",
      "methods": [],
      "indications": [
        "skin-aging",
        "fundamentals-safety"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "34830187",
      "year": 2021,
      "title": "Ammonium Formate-Pd/C as a New Reducing System for 1,2,4-Oxadiazoles. Synthesis of Guanidine Derivatives and Reductive Rearrangement to Quinazolin-4-Ones with Potential Anti-Diabetic Activity.",
      "title_en": null,
      "title_de": "Ammoniumformiat-Pd/C als neues Reduktionssystem für 1,2,4-Oxadiazole: Synthese von Guanidin-Derivaten und reduktive Umlagerung zu Chinazolin-4-onen mit potenzieller antidiabetischer Aktivität",
      "journal": "International journal of molecular sciences",
      "authors": "Marzullo et al.",
      "author_search": "marzullo marzullo",
      "doi": "10.3390/ijms222212301",
      "doi_url": "https://doi.org/10.3390/ijms222212301",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34830187/",
      "url": "https://h2medicine.org/studies/study-marzullo-2021-ammonium-formate-reducing-system/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "diabetes",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "34781966",
      "year": 2021,
      "title": "Hydrogen gas with extracorporeal cardiopulmonary resuscitation improves survival after prolonged cardiac arrest in rats.",
      "title_en": null,
      "title_de": "Wasserstoffgas in Kombination mit extrakorporaler kardiopulmonaler Reanimation verbessert das Überleben nach längerem Herzstillstand bei Ratten",
      "journal": "Journal of translational medicine",
      "authors": "Yin et al.",
      "author_search": "yin yin",
      "doi": "10.1186/s12967-021-03129-1",
      "doi_url": "https://doi.org/10.1186/s12967-021-03129-1",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34781966/",
      "url": "https://h2medicine.org/studies/study-yin-2021-extracorporeal-cardiopulmonary-resuscitation-improves/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "neurology",
        "cardiovascular",
        "cancer",
        "respiratory",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "34674744",
      "year": 2021,
      "title": "Effect of hydrogen gas inhalation on patient QOL after hepatectomy: protocol for a randomized controlled trial.",
      "title_en": null,
      "title_de": "Wirkung der Inhalation von Wasserstoffgas auf die Lebensqualität von Patienten nach Hepatektomie: Protokoll für eine randomisierte kontrollierte Studie",
      "journal": "Trials",
      "authors": "Kaibori et al.",
      "author_search": "kaibori kaibori",
      "doi": "10.1186/s13063-021-05697-5",
      "doi_url": "https://doi.org/10.1186/s13063-021-05697-5",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34674744/",
      "url": "https://h2medicine.org/studies/study-kaibori-2021-inhalation-qol-after-hepatectomy/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "liver",
        "sports-exercise",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "34645100",
      "year": 2021,
      "title": "An H2-infused, nitric oxide-producing functional beverage as a neuroprotective agent for TBIs and concussions.",
      "title_en": null,
      "title_de": "Ein H₂-angereichertes, Stickstoffmonoxid-produzierendes funktionelles Getränk als neuroprotektives Mittel bei Schädel-Hirn-Traumata und Gehirnerschütterungen",
      "journal": "Journal of integrative neuroscience",
      "authors": "LeBaron et al.",
      "author_search": "lebaron le baron",
      "doi": "10.31083/j.jin2003071",
      "doi_url": "https://doi.org/10.31083/j.jin2003071",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34645100/",
      "url": "https://h2medicine.org/studies/study-lebaron-2021-infused-nitric-oxide-producing/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "liver",
        "sports-exercise",
        "neurology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "34585957",
      "year": 2021,
      "title": "Reply to \"Discussion: Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study\".",
      "title_en": null,
      "title_de": "Erwiderung auf „Diskussion: Das Trinken von Wasserstoffwasser steigert die Ausdauer und lindert psychometrische Erschöpfung: eine randomisierte, doppelblinde, placebokontrollierte Studie”",
      "journal": "Canadian journal of physiology and pharmacology",
      "authors": "Ohta et al.",
      "author_search": "ohta ohta",
      "doi": "10.1139/cjpp-2021-0151",
      "doi_url": "https://doi.org/10.1139/cjpp-2021-0151",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34585957/",
      "url": "https://h2medicine.org/studies/study-ohta-2021-reply-discussion-drinking-enhances/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "34585956",
      "year": 2021,
      "title": "Discussion: Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study.",
      "title_en": null,
      "title_de": "Diskussion: Das Trinken von Wasserstoffwasser steigert die Ausdauer und lindert psychometrische Erschöpfung: eine randomisierte, doppelblinde, placebokontrollierte Studie",
      "journal": "Canadian journal of physiology and pharmacology",
      "authors": "Falster et al.",
      "author_search": "falster falster",
      "doi": "10.1139/cjpp-2021-0031",
      "doi_url": "https://doi.org/10.1139/cjpp-2021-0031",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34585956/",
      "url": "https://h2medicine.org/studies/study-falster-2021-discussion-drinking-enhances-endurance/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "34524338",
      "year": 2021,
      "title": "In situ hydrogen nanogenerator for bimodal imaging guided synergistic photothermal/hydrogen therapies.",
      "title_en": null,
      "title_de": "In-situ-Wasserstoff-Nanogenerator für bimodal bildgebungsgeführte synergistische photothermische/Wasserstoff-Therapien",
      "journal": "Nanoscale",
      "authors": "Yuan et al.",
      "author_search": "yuan yuan",
      "doi": "10.1039/d1nr03260g",
      "doi_url": "https://doi.org/10.1039/d1nr03260g",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34524338/",
      "url": "https://h2medicine.org/studies/study-yuan-2021-situ-nanogenerator-bimodal-imaging/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cancer",
        "skin-aging"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "34513069",
      "year": 2021,
      "title": "Application of Molecular Hydrogen in Heart Surgery under Cardiopulmonary Bypass.",
      "title_en": null,
      "title_de": "Anwendung von molekularem Wasserstoff in der Herzchirurgie unter Einsatz der Herz-Lungen-Maschine",
      "journal": "Sovremennye tekhnologii v meditsine",
      "authors": "Danilova et al.",
      "author_search": "danilova danilova",
      "doi": "10.17691/stm2021.13.1.09",
      "doi_url": "https://doi.org/10.17691/stm2021.13.1.09",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34513069/",
      "url": "https://h2medicine.org/studies/study-danilova-2021-application-heart-surgery-under/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "metabolic",
        "cardiovascular",
        "respiratory",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "34426524",
      "year": 2021,
      "title": "H2 in Antarctic firn air: Atmospheric reconstructions and implications for anthropogenic emissions.",
      "title_en": null,
      "title_de": "H₂ in antarktischer Firnluft: Atmosphärische Rekonstruktionen und Implikationen für anthropogene Emissionen",
      "journal": "Proceedings of the National Academy of Sciences of the United States of America",
      "authors": "Patterson et al.",
      "author_search": "patterson patterson",
      "doi": "10.1073/pnas.2103335118",
      "doi_url": "https://doi.org/10.1073/pnas.2103335118",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34426524/",
      "url": "https://h2medicine.org/studies/study-patterson-2021-antarctic-firn-air-atmospheric/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cardiovascular"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "34328487",
      "year": 2021,
      "title": "A PdMo bimetallene with precise wavelength adjustment and catalysis for synergistic photothermal ablation and hydrogen therapy of cancer at different depths.",
      "title_en": null,
      "title_de": "Ein PdMo-Bimetallen mit präziser Wellenlängenanpassung und Katalyse für synergistische photothermische Ablation und Wasserstofftherapie von Krebs in unterschiedlichen Tiefen",
      "journal": "Journal of materials chemistry. B",
      "authors": "Bai et al.",
      "author_search": "bai bai",
      "doi": "10.1039/d1tb01284c",
      "doi_url": "https://doi.org/10.1039/d1tb01284c",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34328487/",
      "url": "https://h2medicine.org/studies/study-bai-2021-pdmo-bimetallene-precise-wavelength/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver",
        "cancer",
        "fundamentals-safety"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "34251693",
      "year": 2021,
      "title": "Safety of electrooxidation for urea removal in a wearable artificial kidney is compromised by formation of glucose degradation products.",
      "title_en": null,
      "title_de": "Die Sicherheit der Elektrooxidation zur Harnstoffentfernung in einer tragbaren künstlichen Niere wird durch die Bildung von Glukose-Abbauprodukten beeinträchtigt",
      "journal": "Artificial organs",
      "authors": "van Gelder et al.",
      "author_search": "van gelder van gelder",
      "doi": "10.1111/aor.14040",
      "doi_url": "https://doi.org/10.1111/aor.14040",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34251693/",
      "url": "https://h2medicine.org/studies/study-vangelder-2021-electrooxidation-urea-removal-wearable/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "kidney-dialysis",
        "fundamentals-safety"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "34120062",
      "year": 2021,
      "title": "Microbial food from light, carbon dioxide and hydrogen gas: Kinetic, stoichiometric and nutritional potential of three purple bacteria.",
      "title_en": null,
      "title_de": "Mikrobielle Nahrung aus Licht, Kohlendioxid und Wasserstoffgas: Kinetisches, stöchiometrisches und ernährungsphysiologisches Potenzial dreier Purpurbakterien",
      "journal": "Bioresource technology",
      "authors": "Spanoghe et al.",
      "author_search": "spanoghe spanoghe",
      "doi": "10.1016/j.biortech.2021.125364",
      "doi_url": "https://doi.org/10.1016/j.biortech.2021.125364",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34120062/",
      "url": "https://h2medicine.org/studies/study-spanoghe-2021-microbial-food-light-carbon/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "34085924",
      "year": 2021,
      "title": "Reshaping of bacterial molecular hydrogen metabolism contributes to the outgrowth of commensal E. coli during gut inflammation.",
      "title_en": null,
      "title_de": "Die Umgestaltung des bakteriellen Stoffwechsels von molekularem Wasserstoff trägt zum Auswachsen kommensaler E. coli während einer Darmentzündung bei",
      "journal": "eLife",
      "authors": "Hughes et al.",
      "author_search": "hughes hughes",
      "doi": "10.7554/elife.58609",
      "doi_url": "https://doi.org/10.7554/elife.58609",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34085924/",
      "url": "https://h2medicine.org/studies/study-hughes-2021-reshaping-bacterial-metabolism-contributes/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "34080660",
      "year": 2021,
      "title": "Mechanism of hydrogen on cervical cancer suppression revealed by high‑throughput RNA sequencing.",
      "title_en": null,
      "title_de": "Mechanismus der Wasserstoff-vermittelten Unterdrückung von Gebärmutterhalskrebs, aufgedeckt durch Hochdurchsatz-RNA-Sequenzierung",
      "journal": "Oncology reports",
      "authors": "Chu et al.",
      "author_search": "chu chu",
      "doi": "10.3892/or.2021.8092",
      "doi_url": "https://doi.org/10.3892/or.2021.8092",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34080660/",
      "url": "https://h2medicine.org/studies/study-chu-2021-mechanism-cervical-cancer-suppression/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cancer",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "33899541",
      "year": 2021,
      "title": "Effects of hydrogen as adjuvant treatment for unstable angina.",
      "title_en": null,
      "title_de": "Wirkungen von Wasserstoff als adjuvante Behandlung bei instabiler Angina pectoris",
      "journal": "Experimental biology and medicine (Maywood, N.J.)",
      "authors": "Si et al.",
      "author_search": "si si",
      "doi": "10.1177/15353702211009138",
      "doi_url": "https://doi.org/10.1177/15353702211009138",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33899541/",
      "url": "https://h2medicine.org/studies/study-si-2021-adjuvant-unstable-angina/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "metabolic",
        "cardiovascular",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "33852061",
      "year": 2021,
      "title": "Molecular hydrogen alleviates asthma through inhibiting IL-33/ILC2 axis.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff lindert Asthma durch Hemmung der IL-33/ILC2-Achse",
      "journal": "Inflammation research : official journal of the European Histamine Research Society ... [et al.]",
      "authors": "Zhang et al.",
      "author_search": "zhang zhang",
      "doi": "10.1007/s00011-021-01459-w",
      "doi_url": "https://doi.org/10.1007/s00011-021-01459-w",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33852061/",
      "url": "https://h2medicine.org/studies/study-zhang-2021-alleviates-asthma-through-inhibiting/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "respiratory",
        "immune-system",
        "allergy"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "33783052",
      "year": 2021,
      "title": "Investigations of Dianhydro-D-glucitol adsorbed on AuNPs surface: In silico and in vitro approach based on anticancer activity studies against A549 lung cancer cell lines.",
      "title_en": null,
      "title_de": "Untersuchungen zu Dianhydro-D-glucitol, adsorbiert an der Oberfläche von AuNPs: In-silico- und In-vitro-Ansatz auf Basis von Antikrebsaktivitätsstudien gegen A549-Lungenkrebszelllinien",
      "journal": "Journal of molecular recognition : JMR",
      "authors": "V et al.",
      "author_search": "v v",
      "doi": "10.1002/jmr.2899",
      "doi_url": "https://doi.org/10.1002/jmr.2899",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33783052/",
      "url": "https://h2medicine.org/studies/study-v-2021-investigations-dianhydro-glucitol-adsorbed/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver",
        "cancer",
        "respiratory"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "33767697",
      "year": 2021,
      "title": "Hydrogen Attenuates Endotoxin-Induced Lung Injury by Activating Thioredoxin 1 and Decreasing Tissue Factor Expression.",
      "title_en": null,
      "title_de": "Wasserstoff mindert endotoxininduzierte Lungenschäden durch Aktivierung von Thioredoxin 1 und Senkung der Expression von Gewebefaktor",
      "journal": "Frontiers in immunology",
      "authors": "Li et al.",
      "author_search": "li li",
      "doi": "10.3389/fimmu.2021.625957",
      "doi_url": "https://doi.org/10.3389/fimmu.2021.625957",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33767697/",
      "url": "https://h2medicine.org/studies/study-li-2021-attenuates-endotoxin-induced-lung/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "respiratory",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "33642332",
      "year": 2021,
      "title": "High-flow hydrogen inhalation might suppresses the immune function of middle-aged participants: a self-controlled study.",
      "title_en": null,
      "title_de": "Hochfluss-Wasserstoffinhalation könnte die Immunfunktion von Teilnehmern mittleren Alters unterdrücken: eine eigenkontrollierte Studie",
      "journal": "Medical gas research",
      "authors": "Chen et al.",
      "author_search": "chen chen",
      "doi": "10.4103/2045-9912.310054",
      "doi_url": "https://doi.org/10.4103/2045-9912.310054",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33642332/",
      "url": "https://h2medicine.org/studies/study-chen-2021-high-flow-inhalation-might/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cancer",
        "immune-system"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "33639371",
      "year": 2021,
      "title": "Hydrogen Gas Therapy Attenuates Inflammatory Pathway Signaling in Septic Mice.",
      "title_en": null,
      "title_de": "Wasserstoffgas-Therapie schwächt die Signalübertragung des Entzündungswegs bei septischen Mäusen ab",
      "journal": "The Journal of surgical research",
      "authors": "Matsuura et al.",
      "author_search": "matsuura matsuura",
      "doi": "10.1016/j.jss.2021.01.022",
      "doi_url": "https://doi.org/10.1016/j.jss.2021.01.022",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33639371/",
      "url": "https://h2medicine.org/studies/study-matsuura-2021-attenuates-inflammatory-pathway-signaling/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "liver",
        "cancer",
        "respiratory",
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "33485760",
      "year": 2021,
      "title": "Hydrogen as a Potential Therapeutic in Obesity: Targeting the Brain.",
      "title_en": null,
      "title_de": "Wasserstoff als potenzielles Therapeutikum bei Adipositas: Das Gehirn als Zielstruktur",
      "journal": "Trends in endocrinology and metabolism: TEM",
      "authors": "Ostojic",
      "author_search": "ostojic ostojic",
      "doi": "10.1016/j.tem.2021.01.002",
      "doi_url": "https://doi.org/10.1016/j.tem.2021.01.002",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33485760/",
      "url": "https://h2medicine.org/studies/study-ostojic-2021-therapeutic-obesity-targeting-brain/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "metabolic",
        "neurology"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "33478090",
      "year": 2021,
      "title": "Toward Tailoring the Degradation Rate of Magnesium-Based Biomaterials for Various Medical Applications: Assessing Corrosion, Cytocompatibility and Immunological Effects.",
      "title_en": null,
      "title_de": "Auf dem Weg zur Anpassung der Abbaurate magnesiumbasierter Biomaterialien für verschiedene medizinische Anwendungen: Bewertung von Korrosion, Zytokompatibilität und immunologischen Effekten",
      "journal": "International journal of molecular sciences",
      "authors": "Hartjen et al.",
      "author_search": "hartjen hartjen",
      "doi": "10.3390/ijms22020971",
      "doi_url": "https://doi.org/10.3390/ijms22020971",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33478090/",
      "url": "https://h2medicine.org/studies/study-hartjen-2021-toward-tailoring-degradation-rate/",
      "methods": [
        "inhalation",
        "bath-topical"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "33475845",
      "year": 2021,
      "title": "The prevalence of intestinal dysbiosis in patients referred for antireflux surgery.",
      "title_en": null,
      "title_de": "Die Prävalenz der intestinalen Dysbiose bei Patienten, die zur Antireflux-Chirurgie überwiesen wurden",
      "journal": "Surgical endoscopy",
      "authors": "Haworth et al.",
      "author_search": "haworth haworth",
      "doi": "10.1007/s00464-020-08229-5",
      "doi_url": "https://doi.org/10.1007/s00464-020-08229-5",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33475845/",
      "url": "https://h2medicine.org/studies/study-haworth-2021-prevalence-intestinal-dysbiosis-referred/",
      "methods": [],
      "indications": [
        "other"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "33428716",
      "year": 2021,
      "title": "Dechloromonas and close relatives prevail during hydrogenotrophic denitrification in stimulated microcosms with oxic aquifer material.",
      "title_en": null,
      "title_de": "Dechloromonas und nahe Verwandte dominieren während der hydrogenotrophen Denitrifikation in stimulierten Mikrokosmen mit oxischem Aquifermaterial",
      "journal": "FEMS microbiology ecology",
      "authors": "Duffner et al.",
      "author_search": "duffner duffner",
      "doi": "10.1093/femsec/fiab004",
      "doi_url": "https://doi.org/10.1093/femsec/fiab004",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33428716/",
      "url": "https://h2medicine.org/studies/study-duffner-2021-dechloromonas-close-relatives-prevail/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "33387361",
      "year": 2021,
      "title": "Carcinostatic effects of alkanoyl ascorbate plus platinum nano-colloid and stabilization of the esterolytically resultant ascorbate by hydrogen.",
      "title_en": null,
      "title_de": "Karzinostatische Wirkungen von Alkanoylascorbat plus Platin-Nanokolloid und Stabilisierung des esterolytisch entstandenen Ascorbats durch Wasserstoff",
      "journal": "Human cell",
      "authors": "Kato et al.",
      "author_search": "kato kato",
      "doi": "10.1007/s13577-020-00462-3",
      "doi_url": "https://doi.org/10.1007/s13577-020-00462-3",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33387361/",
      "url": "https://h2medicine.org/studies/study-kato-2021-carcinostatic-alkanoyl-ascorbate-plus/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "cancer",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "33368699",
      "year": 2021,
      "title": "Molecular hydrogen (H2 ) as a potential treatment for acute and chronic fatigue.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff (H₂) als potenzielle Behandlung bei akuter und chronischer Erschöpfung",
      "journal": "Archiv der Pharmazie",
      "authors": "Lucas et al.",
      "author_search": "lucas lucas",
      "doi": "10.1002/ardp.202000378",
      "doi_url": "https://doi.org/10.1002/ardp.202000378",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33368699/",
      "url": "https://h2medicine.org/studies/study-lucas-2021-acute-chronic-fatigue/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise",
        "neurology",
        "respiratory",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "33246703",
      "year": 2021,
      "title": "Cobalt-modified 2D porous organic polymer for highly efficient electrocatalytic removal of toxic urea and nitrophenol.",
      "title_en": null,
      "title_de": "Kobaltmodifiziertes 2D-poröses organisches Polymer zur hocheffizienten elektrokatalytischen Entfernung von toxischem Harnstoff und Nitrophenol",
      "journal": "Chemosphere",
      "authors": "Gopi et al.",
      "author_search": "gopi gopi",
      "doi": "10.1016/j.chemosphere.2020.129052",
      "doi_url": "https://doi.org/10.1016/j.chemosphere.2020.129052",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33246703/",
      "url": "https://h2medicine.org/studies/study-gopi-2021-cobalt-modified-porous-organic/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "33231266",
      "year": 2021,
      "title": "Hydrogen-rich water attenuates the radiotoxicity induced by tritium exposure in vitro and in vivo.",
      "title_en": null,
      "title_de": "Wasserstoffreiches Wasser mindert die durch Tritiumexposition induzierte Radiotoxizität in vitro und in vivo",
      "journal": "Journal of radiation research",
      "authors": "Li et al.",
      "author_search": "li li",
      "doi": "10.1093/jrr/rraa104",
      "doi_url": "https://doi.org/10.1093/jrr/rraa104",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33231266/",
      "url": "https://h2medicine.org/studies/study-li-2021-attenuates-radiotoxicity-induced-tritium/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "metabolic",
        "neurology",
        "cancer",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "33151329",
      "year": 2021,
      "title": "Hydrogen therapy as an effective and novel adjuvant treatment against COVID-19.",
      "title_en": null,
      "title_de": "Wasserstofftherapie als wirksame und neuartige adjuvante Behandlung gegen COVID-19",
      "journal": "QJM : monthly journal of the Association of Physicians",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1093/qjmed/hcaa301",
      "doi_url": "https://doi.org/10.1093/qjmed/hcaa301",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33151329/",
      "url": "https://h2medicine.org/studies/study-wang-2021-effective-adjuvant-against-covid/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "respiratory"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "33151328",
      "year": 2021,
      "title": "Response to: Hydrogen therapy as an effective and novel adjuvant treatment against COVID-19.",
      "title_en": null,
      "title_de": "Antwort auf: Wasserstofftherapie als wirksame und neuartige adjuvante Behandlung gegen COVID-19",
      "journal": "QJM : monthly journal of the Association of Physicians",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1093/qjmed/hcaa302",
      "doi_url": "https://doi.org/10.1093/qjmed/hcaa302",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33151328/",
      "url": "https://h2medicine.org/studies/study-wang-2021-response-effective-adjuvant-against/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "respiratory"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "32962610",
      "year": 2021,
      "title": "Hydrogen Gas as an Exotic Performance-Enhancing Agent: Challenges and Opportunities.",
      "title_en": null,
      "title_de": "Wasserstoffgas als exotisches leistungssteigerndes Mittel: Herausforderungen und Chancen",
      "journal": "Current pharmaceutical design",
      "authors": "Ostojic",
      "author_search": "ostojic ostojic",
      "doi": "10.2174/1381612826666200922155242",
      "doi_url": "https://doi.org/10.2174/1381612826666200922155242",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32962610/",
      "url": "https://h2medicine.org/studies/study-ostojic-2021-exotic-performance-enhancing-agent/",
      "methods": [
        "inhalation",
        "saline-iv",
        "drinking-hrw"
      ],
      "indications": [
        "liver",
        "sports-exercise",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "32954996",
      "year": 2021,
      "title": "Oxidative Stress and Pathways of Molecular Hydrogen Effects in Medicine.",
      "title_en": null,
      "title_de": "Oxidativer Stress und Wirkmechanismen von molekularem Wasserstoff in der Medizin",
      "journal": "Current pharmaceutical design",
      "authors": "Slezak et al.",
      "author_search": "slezak slezak",
      "doi": "10.2174/1381612826666200821114016",
      "doi_url": "https://doi.org/10.2174/1381612826666200821114016",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32954996/",
      "url": "https://h2medicine.org/studies/study-slezak-2021-oxidative-stress-pathways-medicine/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "metabolic",
        "sports-exercise",
        "cancer",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "32940172",
      "year": 2021,
      "title": "Molecular Hydrogen Application in Stroke: Bench to Bedside.",
      "title_en": null,
      "title_de": "Anwendung von molekularem Wasserstoff beim Schlaganfall: Von der Forschung zur klinischen Praxis",
      "journal": "Current pharmaceutical design",
      "authors": "Huang et al.",
      "author_search": "huang huang",
      "doi": "10.2174/1381612826666200917152316",
      "doi_url": "https://doi.org/10.2174/1381612826666200917152316",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32940172/",
      "url": "https://h2medicine.org/studies/study-huang-2021-application-stroke-bench-bedside/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "neurology"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "32632247",
      "year": 2021,
      "title": "Does drinking water rich in hydrogen gas revive brain hypometabolism in neurodegeneration by SCFAs upregulation?",
      "title_en": null,
      "title_de": "Belebt das Trinken von wasserstoffgasreichem Wasser den Hypometabolismus des Gehirns bei Neurodegeneration durch Hochregulation von SCFAs?",
      "journal": "European journal of clinical nutrition",
      "authors": "Ostojic",
      "author_search": "ostojic ostojic",
      "doi": "10.1038/s41430-020-0680-x",
      "doi_url": "https://doi.org/10.1038/s41430-020-0680-x",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32632247/",
      "url": "https://h2medicine.org/studies/study-ostojic-2021-does-drinking-revive-brain/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "neurology"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "32763820",
      "year": 2020,
      "title": "Molecular hydrogen: A potential radioprotective agent",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff: Ein potenzielles Strahlenschutzmittel",
      "journal": "Biomedicine & Pharmacotherapy",
      "authors": "Hu et al.",
      "author_search": "hu hu",
      "doi": "10.1016/j.biopha.2020.110589",
      "doi_url": "https://doi.org/10.1016/j.biopha.2020.110589",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32763820/",
      "url": "https://h2medicine.org/studies/study-hu-2020-radioprotective-agent/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "oxidative-stress",
        "fundamentals",
        "cancer"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "32826628",
      "year": 2020,
      "title": "Prospects of molecular hydrogen in perioperative neuroprotection from basic research to clinical application",
      "title_en": null,
      "title_de": "Perspektiven von molekularem Wasserstoff im perioperativen Nervenschutz: von der Grundlagenforschung zur klinischen Anwendung",
      "journal": "Current Opinion in Anaesthesiology",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1097/aco.0000000000000915",
      "doi_url": "https://doi.org/10.1097/aco.0000000000000915",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32826628/",
      "url": "https://h2medicine.org/studies/study-wang-2020-perioperative-neuroprotection/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "neurology",
        "oxidative-stress",
        "fundamentals"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "33004714",
      "year": 2020,
      "title": "Proposal of next-generation medical care \"Mega-hydrogen Therapy\".",
      "title_en": null,
      "title_de": "Vorschlag einer medizinischen Versorgung der nächsten Generation: „Mega-Wasserstoff-Therapie”",
      "journal": "Medical gas research",
      "authors": "Ichikawa et al.",
      "author_search": "ichikawa ichikawa",
      "doi": "10.4103/2045-9912.296045",
      "doi_url": "https://doi.org/10.4103/2045-9912.296045",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33004714/",
      "url": "https://h2medicine.org/studies/study-ichikawa-2020-proposal-next-generation-medical/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "32729851",
      "year": 2020,
      "title": "Catalytic reductive aminations using molecular hydrogen for synthesis of different kinds of amines.",
      "title_en": null,
      "title_de": "Katalytische reduktive Aminierungen unter Verwendung von molekularem Wasserstoff zur Synthese verschiedener Arten von Aminen",
      "journal": "Chemical Society reviews",
      "authors": "Murugesan et al.",
      "author_search": "murugesan murugesan",
      "doi": "10.1039/c9cs00286c",
      "doi_url": "https://doi.org/10.1039/c9cs00286c",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32729851/",
      "url": "https://h2medicine.org/studies/study-murugesan-2020-catalytic-reductive-aminations-synthesis/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "32189669",
      "year": 2020,
      "title": "A \"philosophical molecule,\" hydrogen may overcome senescence and intractable diseases.",
      "title_en": null,
      "title_de": "Ein „philosophisches Molekül“: Wasserstoff könnte Seneszenz und hartnäckige Erkrankungen überwinden",
      "journal": "Medical gas research",
      "authors": "Hirano et al.",
      "author_search": "hirano hirano",
      "doi": "10.4103/2045-9912.279983",
      "doi_url": "https://doi.org/10.4103/2045-9912.279983",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32189669/",
      "url": "https://h2medicine.org/studies/study-hirano-2020-philosophical-molecule-may-overcome/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "sports-exercise",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "32097610",
      "year": 2020,
      "title": "The future of cryoablation: An abscopal effect.",
      "title_en": null,
      "title_de": "Die Zukunft der Kryoablation: Ein abskopaler Effekt",
      "journal": "Cryobiology",
      "authors": "Chen et al.",
      "author_search": "chen chen",
      "doi": "10.1016/j.cryobiol.2020.02.010",
      "doi_url": "https://doi.org/10.1016/j.cryobiol.2020.02.010",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32097610/",
      "url": "https://h2medicine.org/studies/study-chen-2020-future-cryoablation-abscopal/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cancer",
        "immune-system"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "32015786",
      "year": 2020,
      "title": "Application of Molecular Hydrogen as a Novel Antioxidant in Sports Science.",
      "title_en": null,
      "title_de": "Anwendung von molekularem Wasserstoff als neuartiges Antioxidans in der Sportwissenschaft",
      "journal": "Oxidative medicine and cellular longevity",
      "authors": "Kawamura et al.",
      "author_search": "kawamura kawamura",
      "doi": "10.1155/2020/2328768",
      "doi_url": "https://doi.org/10.1155/2020/2328768",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32015786/",
      "url": "https://h2medicine.org/studies/study-kawamura-2020-application-antioxidant-sports-science/",
      "methods": [
        "inhalation",
        "bath-topical",
        "drinking-hrw"
      ],
      "indications": [
        "diabetes",
        "sports-exercise",
        "neurology",
        "cancer",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "31996394",
      "year": 2020,
      "title": "Molecular Hydrogen Metabolism: a Widespread Trait of Pathogenic Bacteria and Protists.",
      "title_en": null,
      "title_de": "Stoffwechsel von molekularem Wasserstoff: ein weit verbreitetes Merkmal pathogener Bakterien und Protisten",
      "journal": "Microbiology and molecular biology reviews : MMBR",
      "authors": "Benoit et al.",
      "author_search": "benoit benoit",
      "doi": "10.1128/mmbr.00092-19",
      "doi_url": "https://doi.org/10.1128/mmbr.00092-19",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31996394/",
      "url": "https://h2medicine.org/studies/study-benoit-2020-metabolism-widespread-trait-pathogenic/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "metabolic",
        "sports-exercise",
        "respiratory",
        "womens-health"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "31675478",
      "year": 2020,
      "title": "Acute ingestion of hydrogen-rich water does not improve incremental treadmill running performance in endurance-trained athletes",
      "title_en": null,
      "title_de": "Die akute Einnahme von wasserstoffreichem Wasser verbessert die ansteigende Laufleistung auf dem Laufband bei ausdauertrainierten Athleten nicht",
      "journal": "Applied Physiology, Nutrition, and Metabolism",
      "authors": "Ooi et al.",
      "author_search": "ooi ooi",
      "doi": "10.1139/apnm-2019-0553",
      "doi_url": "https://doi.org/10.1139/apnm-2019-0553",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31675478/",
      "url": "https://h2medicine.org/studies/study-ooi-2020-treadmill-running-endurance-athletes/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "32470022",
      "year": 2020,
      "title": "Peripheral endothelial function can be improved by daily consumption of water containing over 7 ppm of dissolved hydrogen: A randomized controlled trial",
      "title_en": null,
      "title_de": "Die periphere Endothelfunktion kann durch den täglichen Konsum von Wasser mit über 7 ppm gelöstem Wasserstoff verbessert werden: Eine randomisierte kontrollierte Studie",
      "journal": "PLoS One",
      "authors": "Ishibashi et al.",
      "author_search": "ishibashi ishibashi",
      "doi": "10.1371/journal.pone.0233484",
      "doi_url": "https://doi.org/10.1371/journal.pone.0233484",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32470022/",
      "url": "https://h2medicine.org/studies/study-ishibashi-2020-peripheral-endothelial-function-7ppm/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "cardiovascular",
        "oxidative-stress"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "32699287",
      "year": 2020,
      "title": "Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial",
      "title_en": null,
      "title_de": "Wasserstoffreiches Wasser reduziert Entzündungsreaktionen und verhindert die Apoptose peripherer Blutzellen bei gesunden Erwachsenen: eine randomisierte, doppelblinde, kontrollierte Studie",
      "journal": "Scientific Reports",
      "authors": "Sim et al.",
      "author_search": "sim sim",
      "doi": "10.1038/s41598-020-68930-2",
      "doi_url": "https://doi.org/10.1038/s41598-020-68930-2",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32699287/",
      "url": "https://h2medicine.org/studies/study-sim-2020-inflammatory-responses-apoptosis-blood-cells/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "oxidative-stress",
        "fundamentals",
        "metabolic"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "33380581",
      "year": 2020,
      "title": "Impact of hydrogen-rich gas mixture inhalation through nasal cannula during post-exercise recovery period on subsequent oxidative stress, muscle damage, and exercise performances in men",
      "title_en": null,
      "title_de": "Auswirkungen der Inhalation eines wasserstoffreichen Gasgemischs über eine Nasenkanüle während der Erholungsphase nach dem Sport auf den nachfolgenden oxidativen Stress, die Muskelschädigung und die sportlichen Leistungen bei Männern",
      "journal": "Medical Gas Research",
      "authors": "Shibayama et al.",
      "author_search": "shibayama shibayama",
      "doi": "10.4103/2045-9912.304222",
      "doi_url": "https://doi.org/10.4103/2045-9912.304222",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33380581/",
      "url": "https://h2medicine.org/studies/study-shibayama-2020-nasal-cannula-post-exercise-recovery-muscle-damage/",
      "methods": [
        "inhalation",
        "bath-topical"
      ],
      "indications": [
        "sports-exercise",
        "oxidative-stress"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "33380582",
      "year": 2020,
      "title": "Two-week continuous supplementation of hydrogen-rich water increases peak oxygen uptake during an incremental cycling exercise test in healthy humans: a randomized, single-blinded, placebo-controlled study",
      "title_en": null,
      "title_de": "Eine zweiwöchige kontinuierliche Supplementierung mit wasserstoffreichem Wasser erhöht die maximale Sauerstoffaufnahme während eines ansteigenden Radergometer-Belastungstests bei gesunden Menschen: eine randomisierte, einfach-verblindete, placebokontrollierte Studie",
      "journal": "Medical Gas Research",
      "authors": "Hori et al.",
      "author_search": "hori hori",
      "doi": "10.4103/2045-9912.304223",
      "doi_url": "https://doi.org/10.4103/2045-9912.304223",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33380582/",
      "url": "https://h2medicine.org/studies/study-hori-2020-peak-oxygen-uptake-cycling-test/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "metabolic"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "32791592",
      "year": 2020,
      "title": "[Changes of nasal nitric oxide in the treatment of allergic rhinitis with hydrogen-rich saline lavage of nasal cavity].",
      "title_en": null,
      "title_de": "Veränderungen des nasalen Stickstoffmonoxids bei der Behandlung der allergischen Rhinitis mit wasserstoffreicher Nasenspülung",
      "journal": "Lin chuang er bi yan hou tou jing wai ke za zhi (Journal of Clinical Otorhinolaryngology Head and Neck Surgery)",
      "authors": "Jin et al.",
      "author_search": "jin jin",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32791592/",
      "url": "https://h2medicine.org/studies/study-jin-2020-allergic-rhinitis-nasal-saline-lavage/",
      "methods": [
        "saline-iv",
        "bath-topical"
      ],
      "indications": [
        "allergy",
        "respiratory"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "33324415",
      "year": 2020,
      "title": "Hydrogen in Patients With Corticosteroid-Refractory/Dependent Chronic Graft-Versus-Host-Disease: A Single-Arm, Multicenter, Open-Label, Phase 2 Trial",
      "title_en": null,
      "title_de": "Wasserstoff bei Patienten mit kortikosteroid-refraktärer/-abhängiger chronischer Graft-versus-Host-Erkrankung: eine einarmige, multizentrische, offene Phase-2-Studie",
      "journal": "Frontiers in Immunology",
      "authors": "Qian et al.",
      "author_search": "qian qian",
      "doi": "10.3389/fimmu.2020.598359",
      "doi_url": "https://doi.org/10.3389/fimmu.2020.598359",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33324415/",
      "url": "https://h2medicine.org/studies/study-qian-2020-chronic-graft-versus-host-disease-phase-2-trial/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "33380580",
      "year": 2020,
      "title": "Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system senescence patients with advanced non-small cell lung cancer: a self-controlled study",
      "title_en": null,
      "title_de": "Zwei Wochen Wasserstoff-Inhalation können die Alterung des adaptiven und angeborenen Immunsystems bei Patienten mit fortgeschrittenem nicht-kleinzelligem Lungenkrebs deutlich umkehren: eine selbstkontrollierte Studie",
      "journal": "Medical Gas Research",
      "authors": "Chen et al.",
      "author_search": "chen chen",
      "doi": "10.4103/2045-9912.304221",
      "doi_url": "https://doi.org/10.4103/2045-9912.304221",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33380580/",
      "url": "https://h2medicine.org/studies/study-chen-2020-inhalation-immune-senescence-lung-cancer/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cancer",
        "immune-system",
        "respiratory"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "33419292",
      "year": 2020,
      "title": "Antioxidant Activity of Hydrogen Water Mask Pack Composed of Gel-Type Emulsion and Hydrogen Generation Powder.",
      "title_en": null,
      "title_de": "Antioxidative Aktivität einer Wasserstoffwasser-Maskenpackung aus gelartiger Emulsion und wasserstofferzeugendem Pulver",
      "journal": "International journal of molecular sciences",
      "authors": "Kwon et al.",
      "author_search": "kwon kwon",
      "doi": "10.3390/ijms21249731",
      "doi_url": "https://doi.org/10.3390/ijms21249731",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33419292/",
      "url": "https://h2medicine.org/studies/study-kwon-2020-antioxidant-activity-mask-pack/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "skin-aging",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "33004708",
      "year": 2020,
      "title": "Effects of hydrogen-rich water prepared by alternating-current-electrolysis on antioxidant activity, DNA oxidative injuries, and diabetes-related markers.",
      "title_en": null,
      "title_de": "Wirkungen von wasserstoffreichem Wasser, hergestellt durch Wechselstrom-Elektrolyse, auf die antioxidative Aktivität, DNA-oxidative Schäden und diabetesbezogene Marker.",
      "journal": "Medical gas research",
      "authors": "Asada et al.",
      "author_search": "asada asada",
      "doi": "10.4103/2045-9912.296041",
      "doi_url": "https://doi.org/10.4103/2045-9912.296041",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33004708/",
      "url": "https://h2medicine.org/studies/study-asada-2020-prepared-alternating-current-electrolysis/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "diabetes",
        "skin-aging",
        "oxidative-stress",
        "fundamentals-safety"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "33004705",
      "year": 2020,
      "title": "Inhalation of molecular hydrogen increases breath acetone excretion during submaximal exercise: a randomized, single-blinded, placebo-controlled study.",
      "title_en": null,
      "title_de": "Inhalation von molekularem Wasserstoff erhöht die Aceton-Ausscheidung in der Atemluft bei submaximaler Belastung: eine randomisierte, einfachblinde, placebokontrollierte Studie.",
      "journal": "Medical gas research",
      "authors": "Hori et al.",
      "author_search": "hori hori",
      "doi": "10.4103/2045-9912.296038",
      "doi_url": "https://doi.org/10.4103/2045-9912.296038",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33004705/",
      "url": "https://h2medicine.org/studies/study-hori-2020-inhalation-increases-breath-acetone/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "metabolic",
        "liver",
        "sports-exercise",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "32865158",
      "year": 2020,
      "title": "COVID-19 and molecular hydrogen inhalation.",
      "title_en": null,
      "title_de": "COVID-19 und Inhalation von molekularem Wasserstoff",
      "journal": "Therapeutic advances in respiratory disease",
      "authors": "Ostojic",
      "author_search": "ostojic ostojic",
      "doi": "10.1177/1753466620951051",
      "doi_url": "https://doi.org/10.1177/1753466620951051",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32865158/",
      "url": "https://h2medicine.org/studies/study-ostojic-2020-covid-inhalation/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "respiratory"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "32739699",
      "year": 2020,
      "title": "Bio-electrochemical COD removal for energy-efficient, maximum and robust nitrogen recovery from urine through membrane aerated nitrification.",
      "title_en": null,
      "title_de": "Bioelektrochemische CSB-Entfernung für eine energieeffiziente, maximale und robuste Stickstoffrückgewinnung aus Urin durch membranbelüftete Nitrifikation",
      "journal": "Water research",
      "authors": "De Paepe et al.",
      "author_search": "de paepe de paepe",
      "doi": "10.1016/j.watres.2020.116223",
      "doi_url": "https://doi.org/10.1016/j.watres.2020.116223",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32739699/",
      "url": "https://h2medicine.org/studies/study-depaepe-2020-bio-electrochemical-cod-removal/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "32710259",
      "year": 2020,
      "title": "Hydrogen-bubbled platinum-colloid suppresses human esophagus- or tongue-carcinoma cells with intracellular platinum-uptake and the diminished normal-cell mortality.",
      "title_en": null,
      "title_de": "Wasserstoffbegastes Platin-Kolloid unterdrückt menschliche Speiseröhren- oder Zungenkarzinomzellen bei intrazellulärer Platin-Aufnahme und verminderter Sterblichkeit normaler Zellen",
      "journal": "Human cell",
      "authors": "Kato et al.",
      "author_search": "kato kato",
      "doi": "10.1007/s13577-020-00402-1",
      "doi_url": "https://doi.org/10.1007/s13577-020-00402-1",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32710259/",
      "url": "https://h2medicine.org/studies/study-kato-2020-bubbled-platinum-colloid-suppresses/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "32553919",
      "year": 2020,
      "title": "A lean magnesium-zinc-calcium alloy ZX00 used for bone fracture stabilization in a large growing-animal model.",
      "title_en": null,
      "title_de": "Eine schlanke Magnesium-Zink-Calcium-Legierung ZX00 zur Stabilisierung von Knochenbrüchen in einem großen, wachsenden Tiermodell",
      "journal": "Acta biomaterialia",
      "authors": "Holweg et al.",
      "author_search": "holweg holweg",
      "doi": "10.1016/j.actbio.2020.06.013",
      "doi_url": "https://doi.org/10.1016/j.actbio.2020.06.013",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32553919/",
      "url": "https://h2medicine.org/studies/study-holweg-2020-lean-magnesium-zinc-calcium/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "joints-rheumatology"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "32541132",
      "year": 2020,
      "title": "Hydrogen therapy can be used to control tumor progression and alleviate the adverse events of medications in patients with advanced non-small cell lung cancer.",
      "title_en": null,
      "title_de": "Die Wasserstofftherapie kann zur Kontrolle des Tumorfortschritts und zur Linderung unerwünschter Wirkungen von Medikamenten bei Patienten mit fortgeschrittenem nicht-kleinzelligem Lungenkarzinom eingesetzt werden.",
      "journal": "Medical gas research",
      "authors": "Chen et al.",
      "author_search": "chen chen",
      "doi": "10.4103/2045-9912.285560",
      "doi_url": "https://doi.org/10.4103/2045-9912.285560",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32541132/",
      "url": "https://h2medicine.org/studies/study-chen-2020-can-used-control-tumor/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cancer",
        "respiratory"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "32505097",
      "year": 2020,
      "title": "Interaction of different cell types with magnesium modified by plasma electrolytic oxidation.",
      "title_en": null,
      "title_de": "Interaktion verschiedener Zelltypen mit durch plasmaelektrolytische Oxidation modifiziertem Magnesium",
      "journal": "Colloids and surfaces. B, Biointerfaces",
      "authors": "Echeverry-Rendon et al.",
      "author_search": "echeverry-rendon echeverry-rendon",
      "doi": "10.1016/j.colsurfb.2020.111153",
      "doi_url": "https://doi.org/10.1016/j.colsurfb.2020.111153",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32505097/",
      "url": "https://h2medicine.org/studies/study-echeverryrendon-2020-interaction-different-cell-types/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "metabolic",
        "liver",
        "cardiovascular",
        "skin-aging",
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "32479062",
      "year": 2020,
      "title": "Photoactivated H2 Nanogenerator for Enhanced Chemotherapy of Bladder Cancer.",
      "title_en": null,
      "title_de": "Photoaktivierter H₂-Nanogenerator für eine verbesserte Chemotherapie des Blasenkarzinoms",
      "journal": "ACS nano",
      "authors": "Sun et al.",
      "author_search": "sun sun",
      "doi": "10.1021/acsnano.0c01300",
      "doi_url": "https://doi.org/10.1021/acsnano.0c01300",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32479062/",
      "url": "https://h2medicine.org/studies/study-sun-2020-photoactivated-nanogenerator-enhanced-chemotherapy/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "sports-exercise",
        "cancer",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "32407476",
      "year": 2020,
      "title": "Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients.",
      "title_en": null,
      "title_de": "Inhalation von Wasserstoffgas (XEN) verbessert die Atemwegsentzündung bei Asthma- und COPD-Patienten.",
      "journal": "QJM : monthly journal of the Association of Physicians",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1093/qjmed/hcaa164",
      "doi_url": "https://doi.org/10.1093/qjmed/hcaa164",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32407476/",
      "url": "https://h2medicine.org/studies/study-wang-2020-xen-inhalation-ameliorates-airway/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cancer",
        "respiratory",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "32399209",
      "year": 2020,
      "title": "Case Report: Acute hydrotherapy with super-saturated hydrogen-rich water for ankle sprain in a professional athlete.",
      "title_en": null,
      "title_de": "Fallbericht: Akute Hydrotherapie mit übersättigtem wasserstoffreichem Wasser bei einer Knöchelverstauchung eines professionellen Athleten.",
      "journal": "F1000Research",
      "authors": "Javorac et al.",
      "author_search": "javorac javorac",
      "doi": "10.12688/f1000research.22850.1",
      "doi_url": "https://doi.org/10.12688/f1000research.22850.1",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32399209/",
      "url": "https://h2medicine.org/studies/study-javorac-2020-acute-hydrotherapy-super-saturated/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "immune-system"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "32380825",
      "year": 2020,
      "title": "NIR-Driven Water Splitting H2 Production Nanoplatform for H2-Mediated Cascade-Amplifying Synergetic Cancer Therapy.",
      "title_en": null,
      "title_de": "NIR-getriebene Nanoplattform zur H₂-Produktion durch Wasserspaltung für eine H₂-vermittelte, kaskadenverstärkende synergistische Krebstherapie",
      "journal": "ACS applied materials & interfaces",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1021/acsami.0c03852",
      "doi_url": "https://doi.org/10.1021/acsami.0c03852",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32380825/",
      "url": "https://h2medicine.org/studies/study-wang-2020-nir-driven-splitting-production/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "fundamentals-safety"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "32376537",
      "year": 2020,
      "title": "[Hydrogen water alleviates paraquat-induced lung fibroblast injury in vitro by enhancing Nrf2 expression].",
      "title_en": null,
      "title_de": "Wasserstoffwasser lindert Paraquat-induzierte Schäden an Lungenfibroblasten in vitro durch Verstärkung der Nrf2-Expression",
      "journal": "Nan fang yi ke da xue xue bao = Journal of Southern Medical University",
      "authors": "Li et al.",
      "author_search": "li li",
      "doi": "10.12122/j.issn.1673-4254.2020.02.15",
      "doi_url": "https://doi.org/10.12122/j.issn.1673-4254.2020.02.15",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32376537/",
      "url": "https://h2medicine.org/studies/study-li-2020-alleviates-paraquat-induced-lung/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "respiratory",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "32314789",
      "year": 2020,
      "title": "Hydrogen gas represses the progression of lung cancer via down-regulating CD47.",
      "title_en": null,
      "title_de": "Wasserstoffgas unterdrückt den Verlauf von Lungenkrebs durch Herunterregulierung von CD47",
      "journal": "Bioscience reports",
      "authors": "Meng et al.",
      "author_search": "meng meng",
      "doi": "10.1042/bsr20192761",
      "doi_url": "https://doi.org/10.1042/bsr20192761",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32314789/",
      "url": "https://h2medicine.org/studies/study-meng-2020-represses-progression-lung-cancer/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cancer",
        "respiratory",
        "skin-aging"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "32302306",
      "year": 2020,
      "title": "Constitutive hydrogen inhalation prevents vascular remodeling via reduction of oxidative stress.",
      "title_en": null,
      "title_de": "Kontinuierliche Wasserstoffinhalation verhindert vaskuläres Remodeling durch Reduktion von oxidativem Stress",
      "journal": "PloS one",
      "authors": "Kiyoi et al.",
      "author_search": "kiyoi kiyoi",
      "doi": "10.1371/journal.pone.0227582",
      "doi_url": "https://doi.org/10.1371/journal.pone.0227582",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32302306/",
      "url": "https://h2medicine.org/studies/study-kiyoi-2020-constitutive-inhalation-prevents-vascular/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "cardiovascular",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "32278311",
      "year": 2020,
      "title": "Effect of aggrecan degradation on the nanomechanics of hyaluronan in extra-fibrillar matrix of annulus fibrosus: A molecular dynamics investigation.",
      "title_en": null,
      "title_de": "Wirkung des Aggrecan-Abbaus auf die Nanomechanik von Hyaluronan in der extrafibrillären Matrix des Anulus fibrosus: Eine molekulardynamische Untersuchung.",
      "journal": "Journal of the mechanical behavior of biomedical materials",
      "authors": "Bhattacharya et al.",
      "author_search": "bhattacharya bhattacharya",
      "doi": "10.1016/j.jmbbm.2020.103752",
      "doi_url": "https://doi.org/10.1016/j.jmbbm.2020.103752",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32278311/",
      "url": "https://h2medicine.org/studies/study-bhattacharya-2020-aggrecan-degradation-nanomechanics-hyaluronan/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "32236175",
      "year": 2020,
      "title": "Effect of thermal treatments on in vitro starch digestibility of sorghum dried noodles.",
      "title_en": null,
      "title_de": "Wirkung thermischer Behandlungen auf die In-vitro-Stärkeverdaulichkeit von getrockneten Sorghum-Nudeln.",
      "journal": "Food & function",
      "authors": "Liu et al.",
      "author_search": "liu liu",
      "doi": "10.1039/c9fo02765c",
      "doi_url": "https://doi.org/10.1039/c9fo02765c",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32236175/",
      "url": "https://h2medicine.org/studies/study-liu-2020-thermal-treatments-vitro-starch/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "diabetes"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "32189665",
      "year": 2020,
      "title": "Hydrogen-rich water suppresses the reduction in blood total antioxidant capacity induced by 3 consecutive days of severe exercise in physically active males.",
      "title_en": null,
      "title_de": "Wasserstoffreiches Wasser unterdrückt die durch 3 aufeinanderfolgende Tage schwerer körperlicher Belastung induzierte Senkung der gesamten antioxidativen Kapazität des Blutes bei körperlich aktiven Männern.",
      "journal": "Medical gas research",
      "authors": "Dobashi et al.",
      "author_search": "dobashi dobashi",
      "doi": "10.4103/2045-9912.279979",
      "doi_url": "https://doi.org/10.4103/2045-9912.279979",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32189665/",
      "url": "https://h2medicine.org/studies/study-dobashi-2020-suppresses-reduction-blood-total/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "32108985",
      "year": 2020,
      "title": "Hydrogen exerts neuroprotection by activation of the miR-21/PI3K/AKT/GSK-3β pathway in an in vitro model of traumatic brain injury.",
      "title_en": null,
      "title_de": "Wasserstoff übt Neuroprotektion durch Aktivierung des miR-21/PI3K/AKT/GSK-3β-Signalwegs in einem In-vitro-Modell des Schädel-Hirn-Traumas aus.",
      "journal": "Journal of cellular and molecular medicine",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1111/jcmm.15051",
      "doi_url": "https://doi.org/10.1111/jcmm.15051",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32108985/",
      "url": "https://h2medicine.org/studies/study-wang-2020-exerts-neuroprotection-activation-mir/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "neurology"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "32058932",
      "year": 2020,
      "title": "Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff mildert sepsisinduzierte Neuroinflammation durch Regulation der Mikroglia-Polarisierung über einen mTOR-Autophagie-abhängigen Signalweg.",
      "journal": "International immunopharmacology",
      "authors": "Zhuang et al.",
      "author_search": "zhuang zhuang",
      "doi": "10.1016/j.intimp.2020.106287",
      "doi_url": "https://doi.org/10.1016/j.intimp.2020.106287",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32058932/",
      "url": "https://h2medicine.org/studies/study-zhuang-2020-attenuates-sepsis-induced-neuroinflammation/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "neurology",
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "32019803",
      "year": 2020,
      "title": "Syntrophy via Interspecies H2 Transfer between Christensenella and Methanobrevibacter Underlies Their Global Cooccurrence in the Human Gut.",
      "title_en": null,
      "title_de": "Syntrophie durch H₂-Transfer zwischen den Arten Christensenella und Methanobrevibacter liegt ihrem globalen gemeinsamen Vorkommen im menschlichen Darm zugrunde.",
      "journal": "mBio",
      "authors": "Ruaud et al.",
      "author_search": "ruaud ruaud",
      "doi": "10.1128/mbio.03235-19",
      "doi_url": "https://doi.org/10.1128/mbio.03235-19",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32019803/",
      "url": "https://h2medicine.org/studies/study-ruaud-2020-syntrophy-interspecies-transfer-between/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "metabolic",
        "sports-exercise"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "31977289",
      "year": 2020,
      "title": "Untethered Soft Robotics with Fully Integrated Wireless Sensing and Actuating Systems for Somatosensory and Respiratory Functions.",
      "title_en": null,
      "title_de": "Kabellose weiche Robotik mit vollständig integrierten drahtlosen Sensor- und Aktuatorsystemen für somatosensorische und respiratorische Funktionen.",
      "journal": "Soft robotics",
      "authors": "Oh et al.",
      "author_search": "oh oh",
      "doi": "10.1089/soro.2019.0066",
      "doi_url": "https://doi.org/10.1089/soro.2019.0066",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31977289/",
      "url": "https://h2medicine.org/studies/study-oh-2020-untethered-soft-robotics-fully/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "respiratory"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "31930571",
      "year": 2020,
      "title": "Molecular hydrogen regulates PTEN-AKT-mTOR signaling via ROS to alleviate peritoneal dialysis-related peritoneal fibrosis.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff reguliert die PTEN-AKT-mTOR-Signalübertragung über ROS, um die mit der Peritonealdialyse verbundene peritoneale Fibrose zu lindern.",
      "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology",
      "authors": "Lu et al.",
      "author_search": "lu lu",
      "doi": "10.1096/fj.201901981r",
      "doi_url": "https://doi.org/10.1096/fj.201901981r",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31930571/",
      "url": "https://h2medicine.org/studies/study-lu-2020-regulates-pten-akt-mtor/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "kidney-dialysis",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "31924176",
      "year": 2020,
      "title": "Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway.",
      "title_en": null,
      "title_de": "Wasserstoff hemmt das Wachstum des Endometriumkarzinoms über einen ROS/NLRP3/Caspase-1/GSDMD-vermittelten pyroptotischen Signalweg.",
      "journal": "BMC cancer",
      "authors": "Yang et al.",
      "author_search": "yang yang",
      "doi": "10.1186/s12885-019-6491-6",
      "doi_url": "https://doi.org/10.1186/s12885-019-6491-6",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31924176/",
      "url": "https://h2medicine.org/studies/study-yang-2020-inhibits-endometrial-cancer-growth/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "cancer",
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "31810604",
      "year": 2020,
      "title": "Molecular hydrogen suppresses superoxide generation in the mitochondrial complex I and reduced mitochondrial membrane potential.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff unterdrückt die Superoxidbildung im mitochondrialen Komplex I und senkt das mitochondriale Membranpotenzial.",
      "journal": "Biochemical and biophysical research communications",
      "authors": "Ishihara et al.",
      "author_search": "ishihara ishihara",
      "doi": "10.1016/j.bbrc.2019.11.135",
      "doi_url": "https://doi.org/10.1016/j.bbrc.2019.11.135",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31810604/",
      "url": "https://h2medicine.org/studies/study-ishihara-2020-suppresses-superoxide-generation-mitochondrial/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise",
        "neurology",
        "joints-rheumatology",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "31746358",
      "year": 2020,
      "title": "Protective effects of hydrogen‑rich saline against experimental diabetic peripheral neuropathy via activation of the mitochondrial ATP‑sensitive potassium channel channels in rats.",
      "title_en": null,
      "title_de": "Schützende Wirkungen von wasserstoffreicher Kochsalzlösung gegen experimentelle diabetische periphere Neuropathie über die Aktivierung mitochondrialer ATP-sensitiver Kaliumkanäle bei Ratten.",
      "journal": "Molecular medicine reports",
      "authors": "Jiao et al.",
      "author_search": "jiao jiao",
      "doi": "10.3892/mmr.2019.10795",
      "doi_url": "https://doi.org/10.3892/mmr.2019.10795",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31746358/",
      "url": "https://h2medicine.org/studies/study-jiao-2020-protective-saline-against-experimental/",
      "methods": [
        "saline-iv",
        "drinking-hrw"
      ],
      "indications": [
        "diabetes",
        "neurology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "32029879",
      "year": 2020,
      "title": "Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch",
      "title_en": null,
      "title_de": "Wasserstoff dämpft allergische Entzündung durch Umkehr eines Umschaltens im Energiestoffwechsel",
      "journal": "Scientific Reports",
      "authors": "Niu et al.",
      "author_search": "niu niu",
      "doi": "10.1038/s41598-020-58999-0",
      "doi_url": "https://doi.org/10.1038/s41598-020-58999-0",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32029879/",
      "url": "https://h2medicine.org/studies/study-niu-2020-allergic-inflammation-energy-metabolic-pathway/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "allergy",
        "respiratory",
        "mechanism",
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "31267691",
      "year": 2019,
      "title": "Micro/Nanomaterials-Augmented Hydrogen Therapy",
      "title_en": null,
      "title_de": "Durch Mikro-/Nanomaterialien verstärkte Wasserstofftherapie",
      "journal": "Advanced Healthcare Materials",
      "authors": "Zhou et al.",
      "author_search": "zhou zhou",
      "doi": "10.1002/adhm.201900463",
      "doi_url": "https://doi.org/10.1002/adhm.201900463",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31267691/",
      "url": "https://h2medicine.org/studies/study-zhou-2019-nanomaterials-augmented-therapy/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "fundamentals",
        "oxidative-stress",
        "cancer"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "31871547",
      "year": 2019,
      "title": "Medical Application of Hydrogen in Hematological Diseases.",
      "title_en": null,
      "title_de": "Medizinische Anwendung von Wasserstoff bei hämatologischen Erkrankungen.",
      "journal": "Oxidative medicine and cellular longevity",
      "authors": "Qian et al.",
      "author_search": "qian qian",
      "doi": "10.1155/2019/3917393",
      "doi_url": "https://doi.org/10.1155/2019/3917393",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31871547/",
      "url": "https://h2medicine.org/studies/study-qian-2019-medical-application-hematological-diseases/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "diabetes",
        "cardiovascular",
        "cancer",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "31509764",
      "year": 2019,
      "title": "Myalgic encephalomyelitis/chronic fatigue syndrome: From pathophysiological insights to novel therapeutic opportunities.",
      "title_en": null,
      "title_de": "Myalgische Enzephalomyelitis/chronisches Erschöpfungssyndrom: Von pathophysiologischen Erkenntnissen zu neuartigen therapeutischen Möglichkeiten.",
      "journal": "Pharmacological research",
      "authors": "Morris et al.",
      "author_search": "morris morris",
      "doi": "10.1016/j.phrs.2019.104450",
      "doi_url": "https://doi.org/10.1016/j.phrs.2019.104450",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31509764/",
      "url": "https://h2medicine.org/studies/study-morris-2019-myalgic-encephalomyelitis-chronic-fatigue/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise",
        "neurology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "31159153",
      "year": 2019,
      "title": "A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress.",
      "title_en": null,
      "title_de": "Ein neuer Ansatz zur Prävention und Behandlung kardiovaskulärer Erkrankungen. Molekularer Wasserstoff reduziert die Auswirkungen von oxidativem Stress signifikant.",
      "journal": "Molecules (Basel, Switzerland)",
      "authors": "LeBaron et al.",
      "author_search": "lebaron le baron",
      "doi": "10.3390/molecules24112076",
      "doi_url": "https://doi.org/10.3390/molecules24112076",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31159153/",
      "url": "https://h2medicine.org/studies/study-lebaron-2019-approach-prevention-cardiovascular-disorders/",
      "methods": [
        "inhalation",
        "saline-iv",
        "drinking-hrw"
      ],
      "indications": [
        "neurology",
        "cardiovascular",
        "cancer",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "31100203",
      "year": 2019,
      "title": "Circulating messenger for neuroprotection induced by molecular hydrogen.",
      "title_en": null,
      "title_de": "Zirkulierender Botenstoff für die durch molekularen Wasserstoff induzierte Neuroprotektion.",
      "journal": "Canadian journal of physiology and pharmacology",
      "authors": "Noda et al.",
      "author_search": "noda noda",
      "doi": "10.1139/cjpp-2019-0098",
      "doi_url": "https://doi.org/10.1139/cjpp-2019-0098",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31100203/",
      "url": "https://h2medicine.org/studies/study-noda-2019-circulating-messenger-neuroprotection-induced/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "neurology",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "31057105",
      "year": 2019,
      "title": "Therapeutic Efficacy of Molecular Hydrogen: A New Mechanistic Insight.",
      "title_en": null,
      "title_de": "Therapeutische Wirksamkeit von molekularem Wasserstoff: Ein neuer mechanistischer Einblick.",
      "journal": "Current pharmaceutical design",
      "authors": "Ishibashi",
      "author_search": "ishibashi ishibashi",
      "doi": "10.2174/1381612825666190506123038",
      "doi_url": "https://doi.org/10.2174/1381612825666190506123038",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31057105/",
      "url": "https://h2medicine.org/studies/study-ishibashi-2019-therapeutic-mechanistic-insight/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "neurology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "30970215",
      "year": 2019,
      "title": "Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes 1.",
      "title_en": null,
      "title_de": "Wasserstoffgas: von der klinischen Medizin zu einem aufkommenden ergogenen Molekül für Sportler.",
      "journal": "Canadian journal of physiology and pharmacology",
      "authors": "LeBaron et al.",
      "author_search": "lebaron le baron",
      "doi": "10.1139/cjpp-2019-0067",
      "doi_url": "https://doi.org/10.1139/cjpp-2019-0067",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30970215/",
      "url": "https://h2medicine.org/studies/study-lebaron-2019-medicine-emerging-ergogenic-molecule/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "30773939",
      "year": 2019,
      "title": "The preventive and therapeutic effects of molecular hydrogen in ocular diseases and injuries where oxidative stress is involved.",
      "title_en": null,
      "title_de": "Die präventiven und therapeutischen Wirkungen von molekularem Wasserstoff bei Augenerkrankungen und -verletzungen, an denen oxidativer Stress beteiligt ist.",
      "journal": "Free radical research",
      "authors": "Cejka et al.",
      "author_search": "cejka cejka",
      "doi": "10.1080/10715762.2019.1582770",
      "doi_url": "https://doi.org/10.1080/10715762.2019.1582770",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30773939/",
      "url": "https://h2medicine.org/studies/study-cejka-2019-preventive-therapeutic-ocular-diseases/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "neurology",
        "eye",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "30543459",
      "year": 2019,
      "title": "Molecular hydrogen: potential in mitigating oxidative-stress-induced radiation injury 1.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff: Potenzial zur Minderung von durch oxidativen Stress induzierten Strahlenschäden.",
      "journal": "Canadian journal of physiology and pharmacology",
      "authors": "Kura et al.",
      "author_search": "kura kura",
      "doi": "10.1139/cjpp-2018-0604",
      "doi_url": "https://doi.org/10.1139/cjpp-2018-0604",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30543459/",
      "url": "https://h2medicine.org/studies/study-kura-2019-mitigating-oxidative-stress-induced/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "metabolic",
        "cardiovascular",
        "cancer",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "30529801",
      "year": 2019,
      "title": "Hydrogen as a complementary therapy against ischemic stroke: A review of the evidence.",
      "title_en": null,
      "title_de": "Wasserstoff als komplementäre Therapie gegen den ischämischen Schlaganfall: Eine Übersicht über die Evidenz.",
      "journal": "Journal of the neurological sciences",
      "authors": "Li et al.",
      "author_search": "li li",
      "doi": "10.1016/j.jns.2018.11.004",
      "doi_url": "https://doi.org/10.1016/j.jns.2018.11.004",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30529801/",
      "url": "https://h2medicine.org/studies/study-li-2019-complementary-against-ischemic-stroke/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "neurology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "29681183",
      "year": 2019,
      "title": "Neonatal hypoxic-ischemic encephalopathy: emerging therapeutic strategies based on pathophysiologic phases of the injury.",
      "title_en": null,
      "title_de": "Neonatale hypoxisch-ischämische Enzephalopathie: aufkommende therapeutische Strategien auf Basis der pathophysiologischen Phasen der Schädigung.",
      "journal": "The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1080/14767058.2018.1468881",
      "doi_url": "https://doi.org/10.1080/14767058.2018.1468881",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29681183/",
      "url": "https://h2medicine.org/studies/study-wang-2019-neonatal-hypoxic-ischemic-encephalopathy/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "sports-exercise",
        "neurology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "31251888",
      "year": 2019,
      "title": "Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study",
      "title_en": null,
      "title_de": "Trinken von Wasserstoffwasser steigert die Ausdauer und lindert psychometrische Ermüdung: eine randomisierte, doppelblinde, placebo-kontrollierte Studie",
      "journal": "Canadian Journal of Physiology and Pharmacology",
      "authors": "Mikami et al.",
      "author_search": "mikami mikami",
      "doi": "10.1139/cjpp-2019-0059",
      "doi_url": "https://doi.org/10.1139/cjpp-2019-0059",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31251888/",
      "url": "https://h2medicine.org/studies/study-mikami-2019-endurance-psychometric-fatigue/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "oxidative-stress"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "31574544",
      "year": 2019,
      "title": "Hydrogen Rich Water Improved Ventilatory, Perceptual and Lactate Responses to Exercise",
      "title_en": null,
      "title_de": "Wasserstoffreiches Wasser verbesserte ventilatorische, perzeptuelle und Laktat-Reaktionen auf Belastung",
      "journal": "International Journal of Sports Medicine",
      "authors": "Botek et al.",
      "author_search": "botek botek",
      "doi": "10.1055/a-0991-0268",
      "doi_url": "https://doi.org/10.1055/a-0991-0268",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31574544/",
      "url": "https://h2medicine.org/studies/study-botek-2019-ventilatory-lactate-responses-exercise/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "30982748",
      "year": 2019,
      "title": "Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial.",
      "title_en": null,
      "title_de": "Wasserstoffreiches Wasser reduziert die Fettansammlung in der Leber und verbessert die Leberenzymprofile bei Patienten mit nicht-alkoholischer Fettlebererkrankung: eine randomisierte kontrollierte Pilotstudie.",
      "journal": "Clinics and research in hepatology and gastroenterology",
      "authors": "Korovljev et al.",
      "author_search": "korovljev korovljev",
      "doi": "10.1016/j.clinre.2019.03.008",
      "doi_url": "https://doi.org/10.1016/j.clinre.2019.03.008",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30982748/",
      "url": "https://h2medicine.org/studies/study-korovljev-2019-reduces-liver-fat-accumulation/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "metabolic",
        "liver",
        "fundamentals-safety"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "30542740",
      "year": 2019,
      "title": "Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve prognosis.",
      "title_en": null,
      "title_de": "Wasserstoffgas stellt erschöpfte CD8+-T-Zellen bei Patienten mit fortgeschrittenem kolorektalem Karzinom wieder her und verbessert so die Prognose.",
      "journal": "Oncology reports",
      "authors": "Akagi et al.",
      "author_search": "akagi akagi",
      "doi": "10.3892/or.2018.6841",
      "doi_url": "https://doi.org/10.3892/or.2018.6841",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30542740/",
      "url": "https://h2medicine.org/studies/study-akagi-2019-restores-exhausted-cd8-cells/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cancer"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "32595937",
      "year": 2019,
      "title": "Case Report: Buccal administration of hydrogen-producing blend after a mild traumatic brain injury in a professional athlete.",
      "title_en": null,
      "title_de": "Fallbericht: Bukkale Verabreichung einer wasserstoffproduzierenden Mischung nach einem leichten Schädel-Hirn-Trauma bei einem professionellen Athleten.",
      "journal": "F1000Research",
      "authors": "Javorac et al.",
      "author_search": "javorac javorac",
      "doi": "10.12688/f1000research.19739.1",
      "doi_url": "https://doi.org/10.12688/f1000research.19739.1",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32595937/",
      "url": "https://h2medicine.org/studies/study-javorac-2019-buccal-administration-producing-blend/",
      "methods": [
        "tablets",
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "neurology",
        "fundamentals-safety"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "32255077",
      "year": 2019,
      "title": "Acid-responsive H2-releasing Fe nanoparticles for safe and effective cancer therapy.",
      "title_en": null,
      "title_de": "Säureempfindliche, H₂-freisetzende Fe-Nanopartikel für eine sichere und wirksame Krebstherapie.",
      "journal": "Journal of materials chemistry. B",
      "authors": "Kou et al.",
      "author_search": "kou kou",
      "doi": "10.1039/c9tb00338j",
      "doi_url": "https://doi.org/10.1039/c9tb00338j",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32255077/",
      "url": "https://h2medicine.org/studies/study-kou-2019-acid-responsive-releasing-nanoparticles/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "liver",
        "sports-exercise",
        "cancer",
        "skin-aging",
        "immune-system",
        "fundamentals-safety"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "31768722",
      "year": 2019,
      "title": "Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury.",
      "title_en": null,
      "title_de": "Wirkung von wasserstoffreichem Wasser auf den Nrf2/ARE-Signalweg bei Ratten mit myokardialem Ischämie-Reperfusionsschaden.",
      "journal": "Journal of bioenergetics and biomembranes",
      "authors": "Li et al.",
      "author_search": "li li",
      "doi": "10.1007/s10863-019-09814-7",
      "doi_url": "https://doi.org/10.1007/s10863-019-09814-7",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31768722/",
      "url": "https://h2medicine.org/studies/study-li-2019-nrf2-signaling-pathway-rats/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "cardiovascular",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "31738389",
      "year": 2019,
      "title": "Molecular hydrogen: current knowledge on mechanism in alleviating free radical damage and diseases.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff: aktueller Kenntnisstand zum Mechanismus bei der Linderung von Schäden durch freie Radikale und von Erkrankungen.",
      "journal": "Acta biochimica et biophysica Sinica",
      "authors": "Tao et al.",
      "author_search": "tao tao",
      "doi": "10.1093/abbs/gmz121",
      "doi_url": "https://doi.org/10.1093/abbs/gmz121",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31738389/",
      "url": "https://h2medicine.org/studies/study-tao-2019-current-knowledge-mechanism-alleviating/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "metabolic",
        "cancer",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "31737671",
      "year": 2019,
      "title": "Inhaling Hydrogen Ameliorates Early Postresuscitation EEG Characteristics in an Asphyxial Cardiac Arrest Rat Model.",
      "title_en": null,
      "title_de": "Die Inhalation von Wasserstoff verbessert frühe EEG-Charakteristika nach der Reanimation in einem Modell des asphyktischen Herzstillstands bei Ratten.",
      "journal": "BioMed research international",
      "authors": "Chen et al.",
      "author_search": "chen chen",
      "doi": "10.1155/2019/6410159",
      "doi_url": "https://doi.org/10.1155/2019/6410159",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31737671/",
      "url": "https://h2medicine.org/studies/study-chen-2019-inhaling-ameliorates-early-postresuscitation/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "sports-exercise",
        "neurology",
        "cardiovascular",
        "respiratory"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "31622584",
      "year": 2019,
      "title": "Staphylococcus aureus evasion proteins EapH1 and EapH2: Residue-level investigation of an alternative binding motif for human neutrophil elastase.",
      "title_en": null,
      "title_de": "Staphylococcus-aureus-Evasionsproteine EapH1 und EapH2: Untersuchung eines alternativen Bindungsmotivs für die humane neutrophile Elastase auf Residuenebene",
      "journal": "Archives of biochemistry and biophysics",
      "authors": "Herdendorf et al.",
      "author_search": "herdendorf herdendorf",
      "doi": "10.1016/j.abb.2019.108140",
      "doi_url": "https://doi.org/10.1016/j.abb.2019.108140",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31622584/",
      "url": "https://h2medicine.org/studies/study-herdendorf-2019-staphylococcus-aureus-evasion-proteins/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "31600256",
      "year": 2019,
      "title": "Positive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in an animal model of Parkinson's disease.",
      "title_en": null,
      "title_de": "Positive Wirkung von elektrolysiertem reduziertem Wasser auf die Darmpermeabilität, die fäkale Mikrobiota und die Leber in einem Tiermodell der Parkinson-Krankheit",
      "journal": "PloS one",
      "authors": "Bordoni et al.",
      "author_search": "bordoni bordoni",
      "doi": "10.1371/journal.pone.0223238",
      "doi_url": "https://doi.org/10.1371/journal.pone.0223238",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31600256/",
      "url": "https://h2medicine.org/studies/study-bordoni-2019-positive-electrolyzed-reduced-gut/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "liver",
        "neurology",
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "31574947",
      "year": 2019,
      "title": "In Vivo Simulation of Magnesium Degradability Using a New Fluid Dynamic Bench Testing Approach.",
      "title_en": null,
      "title_de": "In-vivo-Simulation der Magnesium-Abbaubarkeit mithilfe eines neuen strömungsdynamischen Prüfstandsansatzes",
      "journal": "International journal of molecular sciences",
      "authors": "Jung et al.",
      "author_search": "jung jung",
      "doi": "10.3390/ijms20194859",
      "doi_url": "https://doi.org/10.3390/ijms20194859",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31574947/",
      "url": "https://h2medicine.org/studies/study-jung-2019-vivo-simulation-magnesium-degradability/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "31574107",
      "year": 2019,
      "title": "Organ preservation solution containing dissolved hydrogen gas from a hydrogen-absorbing alloy canister improves function of transplanted ischemic kidneys in miniature pigs.",
      "title_en": null,
      "title_de": "Eine Organkonservierungslösung mit gelöstem Wasserstoffgas aus einem wasserstoffabsorbierenden Legierungsbehälter verbessert die Funktion transplantierter ischämischer Nieren bei Miniaturschweinen",
      "journal": "PloS one",
      "authors": "Kobayashi et al.",
      "author_search": "kobayashi kobayashi",
      "doi": "10.1371/journal.pone.0222863",
      "doi_url": "https://doi.org/10.1371/journal.pone.0222863",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31574107/",
      "url": "https://h2medicine.org/studies/study-kobayashi-2019-organ-preservation-solution-containing/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "kidney-dialysis",
        "fundamentals-safety"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "31552873",
      "year": 2019,
      "title": "\"Real world survey\" of hydrogen-controlled cancer: a follow-up report of 82 advanced cancer patients.",
      "title_en": null,
      "title_de": "„Real-World-Erhebung“ zur wasserstoffgesteuerten Krebsbehandlung: ein Folgebericht über 82 Patienten mit fortgeschrittenem Krebs.",
      "journal": "Medical gas research",
      "authors": "Chen et al.",
      "author_search": "chen chen",
      "doi": "10.4103/2045-9912.266985",
      "doi_url": "https://doi.org/10.4103/2045-9912.266985",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31552873/",
      "url": "https://h2medicine.org/studies/study-chen-2019-real-world-survey-cancer/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "liver",
        "sports-exercise",
        "cancer",
        "respiratory",
        "skin-aging",
        "immune-system",
        "womens-health",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "31499254",
      "year": 2019,
      "title": "Hydrogen gas improves photothermal therapy of tumor and restrains the relapse of distant dormant tumor.",
      "title_en": null,
      "title_de": "Wasserstoffgas verbessert die photothermische Therapie von Tumoren und hemmt das Wiederauftreten ruhender Ferntumoren",
      "journal": "Biomaterials",
      "authors": "Zhang et al.",
      "author_search": "zhang zhang",
      "doi": "10.1016/j.biomaterials.2019.119472",
      "doi_url": "https://doi.org/10.1016/j.biomaterials.2019.119472",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31499254/",
      "url": "https://h2medicine.org/studies/study-zhang-2019-improves-photothermal-tumor-restrains/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "sports-exercise",
        "cancer",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "31479580",
      "year": 2019,
      "title": "Lifetime of Parahydrogen in Aqueous Solutions and Human Blood.",
      "title_en": null,
      "title_de": "Lebensdauer von Parawasserstoff in wässrigen Lösungen und menschlichem Blut",
      "journal": "Chemphyschem : a European journal of chemical physics and physical chemistry",
      "authors": "Schmidt et al.",
      "author_search": "schmidt schmidt",
      "doi": "10.1002/cphc.201900670",
      "doi_url": "https://doi.org/10.1002/cphc.201900670",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31479580/",
      "url": "https://h2medicine.org/studies/study-schmidt-2019-lifetime-parahydrogen-aqueous-solutions/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "31352109",
      "year": 2019,
      "title": "Effect of physical cues of altered extract media from biodegradable magnesium implants on human gingival fibroblasts.",
      "title_en": null,
      "title_de": "Wirkung physikalischer Reize von verändertem Extraktmedium aus biologisch abbaubaren Magnesiumimplantaten auf menschliche Gingivafibroblasten",
      "journal": "Acta biomaterialia",
      "authors": "Amberg et al.",
      "author_search": "amberg amberg",
      "doi": "10.1016/j.actbio.2019.07.022",
      "doi_url": "https://doi.org/10.1016/j.actbio.2019.07.022",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31352109/",
      "url": "https://h2medicine.org/studies/study-amberg-2019-physical-cues-altered-extract/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise",
        "oral-health"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "31329427",
      "year": 2019,
      "title": "Hydrogen Gas from Inflammation Treatment to Cancer Therapy.",
      "title_en": null,
      "title_de": "Wasserstoffgas: Von der Entzündungsbehandlung zur Krebstherapie",
      "journal": "ACS nano",
      "authors": "Wu et al.",
      "author_search": "wu wu",
      "doi": "10.1021/acsnano.9b05124",
      "doi_url": "https://doi.org/10.1021/acsnano.9b05124",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31329427/",
      "url": "https://h2medicine.org/studies/study-wu-2019-inflammation-cancer/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "liver",
        "cancer",
        "immune-system",
        "fundamentals-safety"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "31323168",
      "year": 2019,
      "title": "Skin ulcers infected with conditional pathogenic strains treated with local hydrogen water packing in two pemphigus vulgaris patients: Case reports with follow-up for 2 months.",
      "title_en": null,
      "title_de": "Mit bedingt pathogenen Stämmen infizierte Hautgeschwüre, behandelt mit lokaler Wasserstoffwasser-Auflage bei zwei Patienten mit Pemphigus vulgaris: Fallberichte mit zweimonatiger Nachbeobachtung.",
      "journal": "Dermatologic therapy",
      "authors": "Yang et al.",
      "author_search": "yang yang",
      "doi": "10.1111/dth.13027",
      "doi_url": "https://doi.org/10.1111/dth.13027",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31323168/",
      "url": "https://h2medicine.org/studies/study-yang-2019-skin-ulcers-infected-conditional/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "skin-aging",
        "immune-system"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "31295412",
      "year": 2019,
      "title": "Molecular hydrogen suppresses free-radical-induced cell death by mitigating fatty acid peroxidation and mitochondrial dysfunction.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff unterdrückt den durch freie Radikale induzierten Zelltod durch Minderung der Fettsäure-Peroxidation und der mitochondrialen Dysfunktion",
      "journal": "Canadian journal of physiology and pharmacology",
      "authors": "Iuchi et al.",
      "author_search": "iuchi iuchi",
      "doi": "10.1139/cjpp-2018-0741",
      "doi_url": "https://doi.org/10.1139/cjpp-2018-0741",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31295412/",
      "url": "https://h2medicine.org/studies/study-iuchi-2019-suppresses-free-radical-induced/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "31249254",
      "year": 2019,
      "title": "Effects of hydrogen-rich water bath on visceral fat and skin blotch, with boiling-resistant hydrogen bubbles.",
      "title_en": null,
      "title_de": "Wirkungen eines Bades in wasserstoffreichem Wasser auf das viszerale Fett und Hautflecken, mit kochbeständigen Wasserstoffbläschen.",
      "journal": "Medical gas research",
      "authors": "Asada et al.",
      "author_search": "asada asada",
      "doi": "10.4103/2045-9912.260647",
      "doi_url": "https://doi.org/10.4103/2045-9912.260647",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31249254/",
      "url": "https://h2medicine.org/studies/study-asada-2019-bath-visceral-fat-skin/",
      "methods": [
        "bath-topical",
        "drinking-hrw"
      ],
      "indications": [
        "metabolic",
        "cardiovascular",
        "skin-aging",
        "fundamentals-safety"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "31162794",
      "year": 2019,
      "title": "Energy conservation in the gut microbe Methanomassiliicoccus luminyensis is based on membrane-bound ferredoxin oxidation coupled to heterodisulfide reduction.",
      "title_en": null,
      "title_de": "Energiekonservierung im Darmmikroben Methanomassiliicoccus luminyensis beruht auf membrangebundener Ferredoxin-Oxidation gekoppelt an Heterodisulfid-Reduktion",
      "journal": "The FEBS journal",
      "authors": "Kröninger et al.",
      "author_search": "kröninger kröninger",
      "doi": "10.1111/febs.14948",
      "doi_url": "https://doi.org/10.1111/febs.14948",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31162794/",
      "url": "https://h2medicine.org/studies/study-kroeninger-2019-energy-conservation-gut-microbe/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise",
        "respiratory",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "31151236",
      "year": 2019,
      "title": "Different Molecular Interaction between Collagen and α- or β-Chitin in Mechanically Improved Electrospun Composite.",
      "title_en": null,
      "title_de": "Unterschiedliche molekulare Wechselwirkung zwischen Kollagen und α- bzw. β-Chitin in mechanisch verbessertem elektrogesponnenem Komposit",
      "journal": "Marine drugs",
      "authors": "Moon et al.",
      "author_search": "moon moon",
      "doi": "10.3390/md17060318",
      "doi_url": "https://doi.org/10.3390/md17060318",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31151236/",
      "url": "https://h2medicine.org/studies/study-moon-2019-different-interaction-between-collagen/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "31113492",
      "year": 2019,
      "title": "Molecular hydrogen suppresses glioblastoma growth via inducing the glioma stem-like cell differentiation.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff unterdrückt das Glioblastom-Wachstum durch Induktion der Differenzierung gliomstammzellähnlicher Zellen",
      "journal": "Stem cell research & therapy",
      "authors": "Liu et al.",
      "author_search": "liu liu",
      "doi": "10.1186/s13287-019-1241-x",
      "doi_url": "https://doi.org/10.1186/s13287-019-1241-x",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31113492/",
      "url": "https://h2medicine.org/studies/study-liu-2019-suppresses-glioblastoma-growth-inducing/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "neurology",
        "cancer",
        "skin-aging"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "31083022",
      "year": 2019,
      "title": "Hydrogen gas protects against ovariectomy-induced osteoporosis by inhibiting NF-κB activation.",
      "title_en": null,
      "title_de": "Wasserstoffgas schützt vor ovariektomie-induzierter Osteoporose durch Hemmung der NF-κB-Aktivierung.",
      "journal": "Menopause (New York, N.Y.)",
      "authors": "Wu et al.",
      "author_search": "wu wu",
      "doi": "10.1097/gme.0000000000001310",
      "doi_url": "https://doi.org/10.1097/gme.0000000000001310",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31083022/",
      "url": "https://h2medicine.org/studies/study-wu-2019-protects-against-ovariectomy-induced/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cancer",
        "joints-rheumatology",
        "immune-system",
        "womens-health"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "31013316",
      "year": 2019,
      "title": "Effects of hydrogen-rich water in a rat model of polycystic kidney disease.",
      "title_en": null,
      "title_de": "Wirkungen von wasserstoffreichem Wasser in einem Rattenmodell der polyzystischen Nierenerkrankung.",
      "journal": "PloS one",
      "authors": "Yamasaki et al.",
      "author_search": "yamasaki yamasaki",
      "doi": "10.1371/journal.pone.0215766",
      "doi_url": "https://doi.org/10.1371/journal.pone.0215766",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31013316/",
      "url": "https://h2medicine.org/studies/study-yamasaki-2019-rat-model-polycystic-kidney/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "metabolic",
        "kidney-dialysis",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "30968583",
      "year": 2019,
      "title": "Acid-Responsive H2 -Releasing 2D MgB2 Nanosheet for Therapeutic Synergy and Side Effect Attenuation of Gastric Cancer Chemotherapy.",
      "title_en": null,
      "title_de": "Säureempfindliches H₂-freisetzendes 2D-MgB₂-Nanoblatt für therapeutische Synergie und Abschwächung von Nebenwirkungen der Magenkrebs-Chemotherapie.",
      "journal": "Advanced healthcare materials",
      "authors": "Fan et al.",
      "author_search": "fan fan",
      "doi": "10.1002/adhm.201900157",
      "doi_url": "https://doi.org/10.1002/adhm.201900157",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30968583/",
      "url": "https://h2medicine.org/studies/study-fan-2019-acid-responsive-releasing-mgb2/",
      "methods": [
        "saline-iv",
        "drinking-hrw"
      ],
      "indications": [
        "liver",
        "sports-exercise",
        "cancer"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "30877875",
      "year": 2019,
      "title": "Hydrogen gas inhalation attenuates sepsis-induced liver injury in a FUNDC1-dependent manner.",
      "title_en": null,
      "title_de": "Wasserstoffgas-Inhalation mildert die sepsis-induzierte Leberschädigung in FUNDC1-abhängiger Weise.",
      "journal": "International immunopharmacology",
      "authors": "Yan et al.",
      "author_search": "yan yan",
      "doi": "10.1016/j.intimp.2019.03.021",
      "doi_url": "https://doi.org/10.1016/j.intimp.2019.03.021",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30877875/",
      "url": "https://h2medicine.org/studies/study-yan-2019-inhalation-attenuates-sepsis-induced/",
      "methods": [
        "inhalation",
        "saline-iv"
      ],
      "indications": [
        "liver",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "30858437",
      "year": 2019,
      "title": "Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model.",
      "title_en": null,
      "title_de": "Wasserstoff-Beatmung kombiniert mit milder Hypothermie verbessert kurzfristige neurologische Ergebnisse in einem 5-Tage-Ferkelmodell der neonatalen Hypoxie-Ischämie.",
      "journal": "Scientific reports",
      "authors": "Htun et al.",
      "author_search": "htun htun",
      "doi": "10.1038/s41598-019-40674-8",
      "doi_url": "https://doi.org/10.1038/s41598-019-40674-8",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30858437/",
      "url": "https://h2medicine.org/studies/study-htun-2019-ventilation-combined-mild-hypothermia/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise",
        "neurology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "30853611",
      "year": 2019,
      "title": "In vitro and in vivo studies of Mg-30Sc alloys with different phase structure for potential usage within bone.",
      "title_en": null,
      "title_de": "In-vitro- und In-vivo-Studien zu Mg-30Sc-Legierungen mit unterschiedlicher Phasenstruktur für die mögliche Anwendung im Knochen.",
      "journal": "Acta biomaterialia",
      "authors": "Liu et al.",
      "author_search": "liu liu",
      "doi": "10.1016/j.actbio.2019.03.009",
      "doi_url": "https://doi.org/10.1016/j.actbio.2019.03.009",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30853611/",
      "url": "https://h2medicine.org/studies/study-liu-2019-vitro-vivo-30sc-alloys/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "liver",
        "sports-exercise",
        "neurology",
        "kidney-dialysis",
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "30825755",
      "year": 2019,
      "title": "Hyperoxygenated Hydrogen-Rich Solution Suppresses Lung Injury Induced by Hemorrhagic Shock in Rats.",
      "title_en": null,
      "title_de": "Hyperoxygenierte wasserstoffreiche Lösung unterdrückt die durch hämorrhagischen Schock induzierte Lungenschädigung bei Ratten.",
      "journal": "The Journal of surgical research",
      "authors": "Meng et al.",
      "author_search": "meng meng",
      "doi": "10.1016/j.jss.2019.01.050",
      "doi_url": "https://doi.org/10.1016/j.jss.2019.01.050",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30825755/",
      "url": "https://h2medicine.org/studies/study-meng-2019-hyperoxygenated-solution-suppresses-lung/",
      "methods": [
        "bath-topical"
      ],
      "indications": [
        "cardiovascular",
        "respiratory",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "30693753",
      "year": 2019,
      "title": "Mechanical Strength, Biodegradation, and in Vitro and in Vivo Biocompatibility of Zn Biomaterials.",
      "title_en": null,
      "title_de": "Mechanische Festigkeit, Bioabbaubarkeit sowie In-vitro- und In-vivo-Biokompatibilität von Zn-Biomaterialien.",
      "journal": "ACS applied materials & interfaces",
      "authors": "Zhu et al.",
      "author_search": "zhu zhu",
      "doi": "10.1021/acsami.8b20634",
      "doi_url": "https://doi.org/10.1021/acsami.8b20634",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30693753/",
      "url": "https://h2medicine.org/studies/study-zhu-2019-mechanical-strength-biodegradation-vitro/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cardiovascular",
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "30660872",
      "year": 2019,
      "title": "Hydrogen gas reduces HMGB1 release in lung tissues of septic mice in an Nrf2/HO-1-dependent pathway.",
      "title_en": null,
      "title_de": "Wasserstoffgas reduziert die HMGB1-Freisetzung im Lungengewebe septischer Mäuse über einen Nrf2/HO-1-abhängigen Signalweg.",
      "journal": "International immunopharmacology",
      "authors": "Yu et al.",
      "author_search": "yu yu",
      "doi": "10.1016/j.intimp.2019.01.022",
      "doi_url": "https://doi.org/10.1016/j.intimp.2019.01.022",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30660872/",
      "url": "https://h2medicine.org/studies/study-yu-2019-reduces-hmgb1-release-lung/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cancer",
        "respiratory",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "30259991",
      "year": 2019,
      "title": "Hydrogen gas reduces chronic intermittent hypoxia-induced hypertension by inhibiting sympathetic nerve activity and increasing vasodilator responses via the antioxidation.",
      "title_en": null,
      "title_de": "Wasserstoffgas reduziert die durch chronische intermittierende Hypoxie induzierte Hypertonie durch Hemmung der sympathischen Nervenaktivität und Steigerung vasodilatatorischer Reaktionen über die Antioxidation.",
      "journal": "Journal of cellular biochemistry",
      "authors": "Guan et al.",
      "author_search": "guan guan",
      "doi": "10.1002/jcb.27684",
      "doi_url": "https://doi.org/10.1002/jcb.27684",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30259991/",
      "url": "https://h2medicine.org/studies/study-guan-2019-reduces-chronic-intermittent-hypoxia/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cardiovascular",
        "kidney-dialysis",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "30367274",
      "year": 2018,
      "title": "Recent Advances in the Electro-Oxidation of Urea for Direct Urea Fuel Cell and Urea Electrolysis.",
      "title_en": null,
      "title_de": "Jüngste Fortschritte bei der Elektrooxidation von Harnstoff für die Direkt-Harnstoff-Brennstoffzelle und die Harnstoff-Elektrolyse.",
      "journal": "Topics in current chemistry (Cham)",
      "authors": "Ye et al.",
      "author_search": "ye ye",
      "doi": "10.1007/s41061-018-0219-y",
      "doi_url": "https://doi.org/10.1007/s41061-018-0219-y",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30367274/",
      "url": "https://h2medicine.org/studies/study-ye-2018-recent-advances-electro-oxidation/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "30107657",
      "year": 2018,
      "title": "[Research progress of hydrogen-rich saline for eye diseases].",
      "title_en": null,
      "title_de": "Forschungsfortschritt zu wasserstoffreicher Kochsalzlösung bei Augenerkrankungen.",
      "journal": "[Zhonghua yan ke za zhi] Chinese journal of ophthalmology",
      "authors": "Chen et al.",
      "author_search": "chen chen",
      "doi": "10.3760/cma.j.issn.0412-4081.2018.08.015",
      "doi_url": "https://doi.org/10.3760/cma.j.issn.0412-4081.2018.08.015",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30107657/",
      "url": "https://h2medicine.org/studies/study-chen-2018-research-progress-saline-eye/",
      "methods": [
        "saline-iv",
        "drinking-hrw"
      ],
      "indications": [
        "cardiovascular",
        "respiratory",
        "kidney-dialysis",
        "eye",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "29763888",
      "year": 2018,
      "title": "Hydrogen Therapy in Cardiovascular and Metabolic Diseases: from Bench to Bedside.",
      "title_en": null,
      "title_de": "Wasserstofftherapie bei kardiovaskulären und metabolischen Erkrankungen: vom Labor zum Krankenbett",
      "journal": "Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology",
      "authors": "Zhang et al.",
      "author_search": "zhang zhang",
      "doi": "10.1159/000489737",
      "doi_url": "https://doi.org/10.1159/000489737",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29763888/",
      "url": "https://h2medicine.org/studies/study-zhang-2018-cardiovascular-metabolic-diseases-bench/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "diabetes",
        "metabolic",
        "liver",
        "sports-exercise",
        "cardiovascular"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "29759891",
      "year": 2018,
      "title": "The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders: Focus on chronic fatigue syndrome, bipolar disorder and multiple sclerosis.",
      "title_en": null,
      "title_de": "Die mutmaßliche Rolle von oxidativem Stress und Entzündung in der Pathophysiologie von Schlafstörungen bei neuropsychiatrischen Erkrankungen",
      "journal": "Sleep medicine reviews",
      "authors": "Morris et al.",
      "author_search": "morris morris",
      "doi": "10.1016/j.smrv.2018.03.007",
      "doi_url": "https://doi.org/10.1016/j.smrv.2018.03.007",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29759891/",
      "url": "https://h2medicine.org/studies/study-morris-2018-putative-oxidative-stress-inflammation/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise",
        "neurology",
        "cancer",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "29683480",
      "year": 2018,
      "title": "Metabolism of hydrogen gases and bile acids in the gut microbiome.",
      "title_en": null,
      "title_de": "Metabolismus von Wasserstoffgasen und Gallensäuren im Darmmikrobiom",
      "journal": "FEBS letters",
      "authors": "Hylemon et al.",
      "author_search": "hylemon hylemon",
      "doi": "10.1002/1873-3468.13064",
      "doi_url": "https://doi.org/10.1002/1873-3468.13064",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29683480/",
      "url": "https://h2medicine.org/studies/study-hylemon-2018-metabolism-gases-bile-acids/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "metabolic",
        "liver",
        "sports-exercise"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "30207619",
      "year": 2018,
      "title": "Randomized, double-blind, multicenter trial of hydrogen water for Parkinson's disease.",
      "title_en": null,
      "title_de": "Randomisierte, doppelblinde, multizentrische Studie zu Wasserstoffwasser bei Morbus Parkinson",
      "journal": "Movement disorders : official journal of the Movement Disorder Society",
      "authors": "Yoritaka et al.",
      "author_search": "yoritaka yoritaka",
      "doi": "10.1002/mds.27472",
      "doi_url": "https://doi.org/10.1002/mds.27472",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30207619/",
      "url": "https://h2medicine.org/studies/study-yoritaka-2018-multicenter-parkinson-disease/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "neurology"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "29798076",
      "year": 2018,
      "title": "[Clinical study of hydrogen-rich saline in the treatment of moderate to severe allergic rhinitis].",
      "title_en": null,
      "title_de": "Klinische Studie zu wasserstoffreicher Kochsalzlösung in der Behandlung von mittelschwerer bis schwerer allergischer Rhinitis",
      "journal": "Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery",
      "authors": "Jin et al.",
      "author_search": "jin jin",
      "doi": "10.13201/j.issn.1001-1781.2018.07.004",
      "doi_url": "https://doi.org/10.13201/j.issn.1001-1781.2018.07.004",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29798076/",
      "url": "https://h2medicine.org/studies/study-jin-2018-saline-moderate-severe-allergic/",
      "methods": [
        "saline-iv",
        "bath-topical"
      ],
      "indications": [
        "allergy",
        "fundamentals-safety"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "29110615",
      "year": 2018,
      "title": "Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment.",
      "title_en": null,
      "title_de": "Wirkungen von molekularem Wasserstoff bei leichter kognitiver Beeinträchtigung, untersucht anhand eines Tiermodells und einer randomisierten klinischen Studie",
      "journal": "Current Alzheimer research",
      "authors": "Nishimaki et al.",
      "author_search": "nishimaki nishimaki",
      "doi": "10.2174/1567205014666171106145017",
      "doi_url": "https://doi.org/10.2174/1567205014666171106145017",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29110615/",
      "url": "https://h2medicine.org/studies/study-nishimaki-2018-assessed-animal-model-mild/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "neurology",
        "cardiovascular",
        "oxidative-stress"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "28560519",
      "year": 2018,
      "title": "Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff beeinflusst Körperzusammensetzung, Stoffwechselprofile und mitochondriale Funktion bei übergewichtigen Frauen mittleren Alters",
      "journal": "Irish journal of medical science",
      "authors": "Korovljev et al.",
      "author_search": "korovljev korovljev",
      "doi": "10.1007/s11845-017-1638-4",
      "doi_url": "https://doi.org/10.1007/s11845-017-1638-4",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/28560519/",
      "url": "https://h2medicine.org/studies/study-korovljev-2018-affects-body-composition-metabolic/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "diabetes",
        "metabolic",
        "fundamentals-safety"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "30586410",
      "year": 2018,
      "title": "Quantification of hydrogen production by intestinal bacteria that are specifically dysregulated in Parkinson's disease.",
      "title_en": null,
      "title_de": "Quantifizierung der Wasserstoffproduktion durch Darmbakterien, die bei Morbus Parkinson spezifisch dysreguliert sind",
      "journal": "PloS one",
      "authors": "Suzuki et al.",
      "author_search": "suzuki suzuki",
      "doi": "10.1371/journal.pone.0208313",
      "doi_url": "https://doi.org/10.1371/journal.pone.0208313",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30586410/",
      "url": "https://h2medicine.org/studies/study-suzuki-2018-quantification-production-intestinal-bacteria/",
      "methods": [],
      "indications": [
        "neurology"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "byproduct"
    },
    {
      "pmid": "30568387",
      "year": 2018,
      "title": "Effects of alkaline-electrolyzed and hydrogen-rich water, in a high-fat-diet nonalcoholic fatty liver disease mouse model.",
      "title_en": null,
      "title_de": "Wirkungen von alkalisch-elektrolysiertem und wasserstoffreichem Wasser in einem Mausmodell der nichtalkoholischen Fettlebererkrankung mit fettreicher Ernährung",
      "journal": "World journal of gastroenterology",
      "authors": "Jackson et al.",
      "author_search": "jackson jackson",
      "doi": "10.3748/wjg.v24.i45.5095",
      "doi_url": "https://doi.org/10.3748/wjg.v24.i45.5095",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30568387/",
      "url": "https://h2medicine.org/studies/study-jackson-2018-alkaline-electrolyzed-high-fat/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "metabolic",
        "liver"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "30419521",
      "year": 2018,
      "title": "Efficient discrimination of natural stereoisomers of chicoric acid, an HIV-1 integrase inhibitor.",
      "title_en": null,
      "title_de": "Effiziente Unterscheidung natürlicher Stereoisomere von Cichoriensäure, einem HIV-1-Integrase-Inhibitor",
      "journal": "Journal of photochemistry and photobiology. B, Biology",
      "authors": "Nobela et al.",
      "author_search": "nobela nobela",
      "doi": "10.1016/j.jphotobiol.2018.10.025",
      "doi_url": "https://doi.org/10.1016/j.jphotobiol.2018.10.025",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30419521/",
      "url": "https://h2medicine.org/studies/study-nobela-2018-efficient-discrimination-natural-stereoisomers/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "30396494",
      "year": 2018,
      "title": "Molecular hydrogen may enhance the production of testosterone hormone in male infertility through hormone signal modulation and redox balance.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff könnte die Testosteronproduktion bei männlicher Infertilität durch Modulation von Hormonsignalen und Redox-Gleichgewicht steigern",
      "journal": "Medical hypotheses",
      "authors": "Begum et al.",
      "author_search": "begum begum",
      "doi": "10.1016/j.mehy.2018.09.001",
      "doi_url": "https://doi.org/10.1016/j.mehy.2018.09.001",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30396494/",
      "url": "https://h2medicine.org/studies/study-begum-2018-may-enhance-production-testosterone/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "metabolic",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "30382050",
      "year": 2018,
      "title": "[Immunological Effect of Hydrogen Gas-Hydrogen Gas Improves Clinical Outcomes of Cancer Patients].",
      "title_en": null,
      "title_de": "Immunologische Wirkung von Wasserstoffgas: Wasserstoffgas verbessert die klinischen Ergebnisse von Krebspatienten",
      "journal": "Gan to kagaku ryoho. Cancer & chemotherapy",
      "authors": "Akagi",
      "author_search": "akagi akagi",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30382050/",
      "url": "https://h2medicine.org/studies/study-akagi-2018-immunological-improves-outcomes-cancer/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cancer"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "30380511",
      "year": 2018,
      "title": "Protective effects of hydrogen gas against sepsis-induced acute lung injury via regulation of mitochondrial function and dynamics.",
      "title_en": null,
      "title_de": "Schützende Wirkungen von Wasserstoffgas gegen sepsis-induzierte akute Lungenschädigung über die Regulation der mitochondrialen Funktion und Dynamik",
      "journal": "International immunopharmacology",
      "authors": "Dong et al.",
      "author_search": "dong dong",
      "doi": "10.1016/j.intimp.2018.10.012",
      "doi_url": "https://doi.org/10.1016/j.intimp.2018.10.012",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30380511/",
      "url": "https://h2medicine.org/studies/study-dong-2018-protective-against-sepsis-induced/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cancer",
        "respiratory",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "30349057",
      "year": 2018,
      "title": "Human gut microbe co-cultures have greater potential than monocultures for food waste remediation to commodity chemicals.",
      "title_en": null,
      "title_de": "Co-Kulturen menschlicher Darmmikroben haben ein größeres Potenzial als Monokulturen für die Verwertung von Lebensmittelabfällen zu Grundchemikalien",
      "journal": "Scientific reports",
      "authors": "Perisin et al.",
      "author_search": "perisin perisin",
      "doi": "10.1038/s41598-018-33733-z",
      "doi_url": "https://doi.org/10.1038/s41598-018-33733-z",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30349057/",
      "url": "https://h2medicine.org/studies/study-perisin-2018-gut-microbe-cultures-have/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "metabolic",
        "sports-exercise"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "30120877",
      "year": 2018,
      "title": "Hydrogen Flush After Cold Storage as a New End-Ischemic Ex Vivo Treatment for Liver Grafts Against Ischemia/Reperfusion Injury.",
      "title_en": null,
      "title_de": "Wasserstoff-Spülung nach Kaltlagerung als neue ischämieendständige Ex-vivo-Behandlung von Lebertransplantaten gegen Ischämie-/Reperfusionsschädigung",
      "journal": "Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society",
      "authors": "Tamaki et al.",
      "author_search": "tamaki tamaki",
      "doi": "10.1002/lt.25326",
      "doi_url": "https://doi.org/10.1002/lt.25326",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30120877/",
      "url": "https://h2medicine.org/studies/study-tamaki-2018-flush-after-cold-storage/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver",
        "cardiovascular",
        "immune-system",
        "oxidative-stress",
        "fundamentals-safety"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "30096818",
      "year": 2018,
      "title": "Reducing Humidity Response of Gas Sensors for Medical Applications: Use of Spark Discharge Synthesis of Metal Oxide Nanoparticles.",
      "title_en": null,
      "title_de": "Reduzierung der Feuchtigkeitsreaktion von Gassensoren für medizinische Anwendungen: Einsatz der Funkenentladungssynthese von Metalloxid-Nanopartikeln",
      "journal": "Sensors (Basel, Switzerland)",
      "authors": "Vasiliev et al.",
      "author_search": "vasiliev vasiliev",
      "doi": "10.3390/s18082600",
      "doi_url": "https://doi.org/10.3390/s18082600",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30096818/",
      "url": "https://h2medicine.org/studies/study-vasiliev-2018-reducing-humidity-response-sensors/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "respiratory"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "30041222",
      "year": 2018,
      "title": "Translational Research of Peritoneal Dialysis Solution with Dissolved Molecular Hydrogen.",
      "title_en": null,
      "title_de": "Translationale Forschung zu Peritonealdialyselösung mit gelöstem molekularem Wasserstoff",
      "journal": "Contributions to nephrology",
      "authors": "Nakayama et al.",
      "author_search": "nakayama nakayama",
      "doi": "10.1159/000485717",
      "doi_url": "https://doi.org/10.1159/000485717",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30041222/",
      "url": "https://h2medicine.org/studies/study-nakayama-2018-translational-research-peritoneal-dialysis/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "kidney-dialysis"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "29923670",
      "year": 2018,
      "title": "An In Situ Depot for Continuous Evolution of Gaseous H2 Mediated by a Magnesium Passivation/Activation Cycle for Treating Osteoarthritis.",
      "title_en": null,
      "title_de": "Ein In-situ-Depot zur kontinuierlichen Entwicklung von gasförmigem H₂, vermittelt durch einen Magnesium-Passivierungs-/Aktivierungszyklus, zur Behandlung von Osteoarthrose",
      "journal": "Angewandte Chemie (International ed. in English)",
      "authors": "Wan et al.",
      "author_search": "wan wan",
      "doi": "10.1002/anie.201806159",
      "doi_url": "https://doi.org/10.1002/anie.201806159",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29923670/",
      "url": "https://h2medicine.org/studies/study-wan-2018-situ-depot-continuous-evolution/",
      "methods": [
        "inhalation",
        "saline-iv"
      ],
      "indications": [
        "liver",
        "joints-rheumatology",
        "immune-system",
        "fundamentals-safety"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "29907217",
      "year": 2018,
      "title": "Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway.",
      "title_en": null,
      "title_de": "Wasserstoffreiches Wasser mildert oxidativen Stress bei Ratten mit traumatischer Hirnverletzung über den Nrf2-Signalweg",
      "journal": "The Journal of surgical research",
      "authors": "Yuan et al.",
      "author_search": "yuan yuan",
      "doi": "10.1016/j.jss.2018.03.024",
      "doi_url": "https://doi.org/10.1016/j.jss.2018.03.024",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29907217/",
      "url": "https://h2medicine.org/studies/study-yuan-2018-attenuates-oxidative-stress-rats/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "neurology",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "29901139",
      "year": 2018,
      "title": "Therapeutic efficacy of hydrogen‑rich saline alone and in combination with PI3K inhibitor in non‑small cell lung cancer.",
      "title_en": null,
      "title_de": "Therapeutische Wirksamkeit von wasserstoffreicher Kochsalzlösung allein und in Kombination mit einem PI3K-Inhibitor beim nichtkleinzelligen Lungenkarzinom",
      "journal": "Molecular medicine reports",
      "authors": "Jiang et al.",
      "author_search": "jiang jiang",
      "doi": "10.3892/mmr.2018.9168",
      "doi_url": "https://doi.org/10.3892/mmr.2018.9168",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29901139/",
      "url": "https://h2medicine.org/studies/study-jiang-2018-therapeutic-saline-alone-combination/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "cancer",
        "respiratory",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "29852353",
      "year": 2018,
      "title": "Hydrogen gas inhibits lung cancer progression through targeting SMC3.",
      "title_en": null,
      "title_de": "Wasserstoffgas hemmt das Fortschreiten von Lungenkrebs durch gezielte Beeinflussung von SMC3",
      "journal": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1016/j.biopha.2018.05.055",
      "doi_url": "https://doi.org/10.1016/j.biopha.2018.05.055",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29852353/",
      "url": "https://h2medicine.org/studies/study-wang-2018-inhibits-lung-cancer-progression/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cancer",
        "respiratory",
        "skin-aging"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "29795283",
      "year": 2018,
      "title": "Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques.",
      "title_en": null,
      "title_de": "Positive Wirkungen von Wasserstoff-Wasser-Bädern bei Patienten mit Psoriasis und Parapsoriasis en plaques",
      "journal": "Scientific reports",
      "authors": "Zhu et al.",
      "author_search": "zhu zhu",
      "doi": "10.1038/s41598-018-26388-3",
      "doi_url": "https://doi.org/10.1038/s41598-018-26388-3",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29795283/",
      "url": "https://h2medicine.org/studies/study-zhu-2018-positive-bathing-psoriasis-parapsoriasis/",
      "methods": [
        "bath-topical",
        "drinking-hrw"
      ],
      "indications": [
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "29779270",
      "year": 2018,
      "title": "[Protective effects of hydrogen-rich medium on lipopolysaccharides-induced injury in human periodontal ligament cells].",
      "title_en": null,
      "title_de": "Schützende Wirkungen von wasserstoffreichem Medium auf lipopolysaccharid-induzierte Schädigung in menschlichen Parodontalligamentzellen",
      "journal": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
      "authors": "Zhou et al.",
      "author_search": "zhou zhou",
      "doi": "10.7518/hxkq.2018.02.002",
      "doi_url": "https://doi.org/10.7518/hxkq.2018.02.002",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29779270/",
      "url": "https://h2medicine.org/studies/study-zhou-2018-protective-medium-lipopolysaccharides-induced/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "oral-health",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "29712968",
      "year": 2018,
      "title": "Lignite coal burning seam in the remote Altai Mountains harbors a hydrogen-driven thermophilic microbial community.",
      "title_en": null,
      "title_de": "Ein brennender Braunkohleflöz in den abgelegenen Altai-Bergen beherbergt eine wasserstoffgetriebene thermophile mikrobielle Gemeinschaft",
      "journal": "Scientific reports",
      "authors": "Kadnikov et al.",
      "author_search": "kadnikov kadnikov",
      "doi": "10.1038/s41598-018-25146-9",
      "doi_url": "https://doi.org/10.1038/s41598-018-25146-9",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29712968/",
      "url": "https://h2medicine.org/studies/study-kadnikov-2018-lignite-coal-burning-seam/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise",
        "cancer"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "29532858",
      "year": 2018,
      "title": "Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells.",
      "title_en": null,
      "title_de": "Wasserstoff mildert oxidativen Stress über den PI3K-Akt-Signalweg in UVB-induzierten HaCaT-Zellen",
      "journal": "International journal of molecular medicine",
      "authors": "Zhang et al.",
      "author_search": "zhang zhang",
      "doi": "10.3892/ijmm.2018.3550",
      "doi_url": "https://doi.org/10.3892/ijmm.2018.3550",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29532858/",
      "url": "https://h2medicine.org/studies/study-zhang-2018-ameliorates-oxidative-stress-pi3k/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "skin-aging",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "29532225",
      "year": 2018,
      "title": "A molecular dynamics approach to explore the structural characterization of cataract causing mutation R58H on human γD crystallin.",
      "title_en": null,
      "title_de": "Ein molekulardynamischer Ansatz zur Untersuchung der strukturellen Charakterisierung der katarakt-verursachenden Mutation R58H im menschlichen γD-Crystallin",
      "journal": "Molecular and cellular biochemistry",
      "authors": "Karunakaran et al.",
      "author_search": "karunakaran karunakaran",
      "doi": "10.1007/s11010-018-3342-8",
      "doi_url": "https://doi.org/10.1007/s11010-018-3342-8",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29532225/",
      "url": "https://h2medicine.org/studies/study-karunakaran-2018-dynamics-approach-explore-structural/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "29512923",
      "year": 2018,
      "title": "Modulation of the oxidative plasmatic state in gastroesophageal reflux disease with the addition of rich water molecular hydrogen: A new biological vision.",
      "title_en": null,
      "title_de": "Modulation des oxidativen Plasmazustands bei gastroösophagealer Refluxkrankheit durch Zusatz von molekular-wasserstoffreichem Wasser: Eine neue biologische Sichtweise",
      "journal": "Journal of cellular and molecular medicine",
      "authors": "Franceschelli et al.",
      "author_search": "franceschelli franceschelli",
      "doi": "10.1111/jcmm.13569",
      "doi_url": "https://doi.org/10.1111/jcmm.13569",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29512923/",
      "url": "https://h2medicine.org/studies/study-franceschelli-2018-modulation-oxidative-plasmatic-state/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cardiovascular",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "29478695",
      "year": 2018,
      "title": "Inadequate Production of H2 by Gut Microbiota and Parkinson Disease.",
      "title_en": null,
      "title_de": "Unzureichende Produktion von H₂ durch die Darmmikrobiota und Morbus Parkinson",
      "journal": "Trends in endocrinology and metabolism: TEM",
      "authors": "Ostojic",
      "author_search": "ostojic ostojic",
      "doi": "10.1016/j.tem.2018.02.006",
      "doi_url": "https://doi.org/10.1016/j.tem.2018.02.006",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29478695/",
      "url": "https://h2medicine.org/studies/study-ostojic-2018-inadequate-production-gut-microbiota/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "neurology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "29321509",
      "year": 2018,
      "title": "Novel haemodialysis (HD) treatment employing molecular hydrogen (H2)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study.",
      "title_en": null,
      "title_de": "Neuartige Hämodialyse-Behandlung mit einer mit molekularem Wasserstoff angereicherten Dialyselösung verbessert die Prognose chronischer Dialysepatienten: Eine prospektive Beobachtungsstudie",
      "journal": "Scientific reports",
      "authors": "Nakayama et al.",
      "author_search": "nakayama nakayama",
      "doi": "10.1038/s41598-017-18537-x",
      "doi_url": "https://doi.org/10.1038/s41598-017-18537-x",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29321509/",
      "url": "https://h2medicine.org/studies/study-nakayama-2018-haemodialysis-employing-enriched-dialysis/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver",
        "cardiovascular",
        "kidney-dialysis",
        "immune-system"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "28474871",
      "year": 2018,
      "title": "Effects of hydrogen rich water on prolonged intermittent exercise.",
      "title_en": null,
      "title_de": "Wirkungen von wasserstoffreichem Wasser auf verlängerte intermittierende Belastung",
      "journal": "The Journal of sports medicine and physical fitness",
      "authors": "Da Ponte et al.",
      "author_search": "da ponte da ponte",
      "doi": "10.23736/s0022-4707.17.06883-9",
      "doi_url": "https://doi.org/10.23736/s0022-4707.17.06883-9",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/28474871/",
      "url": "https://h2medicine.org/studies/study-daponte-2018-prolonged-intermittent-exercise/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "cardiovascular"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "27281176",
      "year": 2017,
      "title": "Molecular Hydrogen as a Neuroprotective Agent",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff als neuroprotektives Agens",
      "journal": "Current Neuropharmacology",
      "authors": "Iketani et al.",
      "author_search": "iketani iketani",
      "doi": "10.2174/1570159x14666160607205417",
      "doi_url": "https://doi.org/10.2174/1570159x14666160607205417",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27281176/",
      "url": "https://h2medicine.org/studies/study-iketani-2017-neuroprotective-agent/",
      "methods": [
        "inhalation",
        "saline-iv",
        "drinking-hrw"
      ],
      "indications": [
        "neurology",
        "fundamentals",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "29058596",
      "year": 2017,
      "title": "Efficacy of inhaled HYdrogen on neurological outcome following BRain Ischemia During post-cardiac arrest care (HYBRID II trial): study protocol for a randomized controlled trial.",
      "title_en": null,
      "title_de": "Wirksamkeit von inhaliertem Wasserstoff auf das neurologische Ergebnis nach Hirnischämie während der Versorgung nach Herzstillstand (HYBRID-II-Studie): Studienprotokoll für eine randomisierte kontrollierte Studie",
      "journal": "Trials",
      "authors": "Tamura et al.",
      "author_search": "tamura tamura",
      "doi": "10.1186/s13063-017-2246-3",
      "doi_url": "https://doi.org/10.1186/s13063-017-2246-3",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29058596/",
      "url": "https://h2medicine.org/studies/study-tamura-2017-inhaled-neurological-outcome-following/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "sports-exercise",
        "neurology",
        "fundamentals-safety"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "28669654",
      "year": 2017,
      "title": "Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection.",
      "title_en": null,
      "title_de": "Behandlung mit Wasserstoffgas-Inhalation beim akuten Hirninfarkt: Eine randomisierte kontrollierte klinische Studie zu Sicherheit und Neuroprotektion.",
      "journal": "Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association",
      "authors": "Ono et al.",
      "author_search": "ono ono",
      "doi": "10.1016/j.jstrokecerebrovasdis.2017.06.012",
      "doi_url": "https://doi.org/10.1016/j.jstrokecerebrovasdis.2017.06.012",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/28669654/",
      "url": "https://h2medicine.org/studies/study-ono-2017-inhalation-acute-cerebral-infarction/",
      "methods": [
        "inhalation",
        "saline-iv"
      ],
      "indications": [
        "sports-exercise",
        "neurology",
        "skin-aging",
        "oxidative-stress",
        "fundamentals-safety"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "30998612",
      "year": 2017,
      "title": "Protective Effect of Hydrogen Gas Inhalation on Muscular Damage Using a Mouse Hindlimb Ischemia-Reperfusion Injury Model.",
      "title_en": null,
      "title_de": "Schützende Wirkung der Wasserstoffgas-Inhalation auf Muskelschäden anhand eines Maus-Hinterlauf-Ischämie-Reperfusions-Schädigungsmodells",
      "journal": "Plastic and reconstructive surgery",
      "authors": "Watanabe et al.",
      "author_search": "watanabe watanabe",
      "doi": "10.1097/prs.0000000000003878",
      "doi_url": "https://doi.org/10.1097/prs.0000000000003878",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30998612/",
      "url": "https://h2medicine.org/studies/study-watanabe-2017-protective-inhalation-muscular-damage/",
      "methods": [
        "inhalation",
        "saline-iv"
      ],
      "indications": [
        "liver",
        "sports-exercise",
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "28902900",
      "year": 2017,
      "title": "Possible clinical effects of molecular hydrogen (H2) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation.",
      "title_en": null,
      "title_de": "Mögliche klinische Wirkungen der Zufuhr von molekularem Wasserstoff (H₂) während der Hämodialyse bei chronischen Dialysepatienten: Zwischenanalyse einer 12-monatigen Beobachtung.",
      "journal": "PloS one",
      "authors": "Nakayama et al.",
      "author_search": "nakayama nakayama",
      "doi": "10.1371/journal.pone.0184535",
      "doi_url": "https://doi.org/10.1371/journal.pone.0184535",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/28902900/",
      "url": "https://h2medicine.org/studies/study-nakayama-2017-possible-delivery-during-hemodialysis/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver",
        "sports-exercise",
        "cardiovascular",
        "kidney-dialysis",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "28856162",
      "year": 2017,
      "title": "Hydrogen-Rich Syngas Production from Gasification and Pyrolysis of Solar Dried Sewage Sludge: Experimental and Modeling Investigations.",
      "title_en": null,
      "title_de": "Produktion von wasserstoffreichem Synthesegas aus Vergasung und Pyrolyse von solar getrocknetem Klärschlamm: Experimentelle und Modellierungsuntersuchungen",
      "journal": "BioMed research international",
      "authors": "Ben Hassen Trabelsi et al.",
      "author_search": "ben hassen trabelsi ben hassen trabelsi",
      "doi": "10.1155/2017/7831470",
      "doi_url": "https://doi.org/10.1155/2017/7831470",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/28856162/",
      "url": "https://h2medicine.org/studies/study-benhassentrabelsi-2017-syngas-production-gasification-pyrolysis/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "28566655",
      "year": 2017,
      "title": "Translational Study of Hydrogen Gas Inhalation as Adjuncts to Reperfusion Therapy for Acute Myocardial Infarction.",
      "title_en": null,
      "title_de": "Translationale Studie zur Wasserstoffgas-Inhalation als Ergänzung zur Reperfusionstherapie beim akuten Myokardinfarkt",
      "journal": "Circulation journal : official journal of the Japanese Circulation Society",
      "authors": "Asanuma et al.",
      "author_search": "asanuma asanuma",
      "doi": "10.1253/circj.cj-17-0520",
      "doi_url": "https://doi.org/10.1253/circj.cj-17-0520",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/28566655/",
      "url": "https://h2medicine.org/studies/study-asanuma-2017-translational-inhalation-adjuncts-reperfusion/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "28467497",
      "year": 2017,
      "title": "Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff schützt vor durch oxidativen Stress induziertem Zelltod von SH-SY5Y-Neuroblastomzellen durch den Prozess der Mitohormesis",
      "journal": "PloS one",
      "authors": "Murakami et al.",
      "author_search": "murakami murakami",
      "doi": "10.1371/journal.pone.0176992",
      "doi_url": "https://doi.org/10.1371/journal.pone.0176992",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/28467497/",
      "url": "https://h2medicine.org/studies/study-murakami-2017-protects-against-oxidative-stress/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "neurology",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "28458345",
      "year": 2017,
      "title": "Hydrogen Rich Water Attenuates Renal Injury and Fibrosis by Regulation Transforming Growth Factor-β Induced Sirt1.",
      "title_en": null,
      "title_de": "Wasserstoffreiches Wasser mildert Nierenschädigung und -fibrose durch Regulation des durch TGF-β induzierten Sirt1",
      "journal": "Biological & pharmaceutical bulletin",
      "authors": "Xing et al.",
      "author_search": "xing xing",
      "doi": "10.1248/bpb.b16-00832",
      "doi_url": "https://doi.org/10.1248/bpb.b16-00832",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/28458345/",
      "url": "https://h2medicine.org/studies/study-xing-2017-attenuates-renal-injury-fibrosis/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "kidney-dialysis"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "28374556",
      "year": 2017,
      "title": "Therapeutic effects of hydrogen on chronic graft-versus-host disease.",
      "title_en": null,
      "title_de": "Therapeutische Wirkungen von Wasserstoff auf die chronische Graft-versus-Host-Erkrankung.",
      "journal": "Journal of cellular and molecular medicine",
      "authors": "Qian et al.",
      "author_search": "qian qian",
      "doi": "10.1111/jcmm.13155",
      "doi_url": "https://doi.org/10.1111/jcmm.13155",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/28374556/",
      "url": "https://h2medicine.org/studies/study-qian-2017-therapeutic-chronic-graft-versus/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "28321000",
      "year": 2017,
      "title": "The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction　- First Pilot Study in Humans.",
      "title_en": null,
      "title_de": "Die Wirkungen der Wasserstoffgas-Inhalation auf das ungünstige linksventrikuläre Remodeling nach perkutaner Koronarintervention bei ST-Hebungsinfarkt — erste Pilotstudie am Menschen.",
      "journal": "Circulation journal : official journal of the Japanese Circulation Society",
      "authors": "Katsumata et al.",
      "author_search": "katsumata katsumata",
      "doi": "10.1253/circj.cj-17-0105",
      "doi_url": "https://doi.org/10.1253/circj.cj-17-0105",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/28321000/",
      "url": "https://h2medicine.org/studies/study-katsumata-2017-inhalation-adverse-left-ventricular/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "neurology",
        "skin-aging"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "28215576",
      "year": 2017,
      "title": "Changes in IL-4 and IL-13 expression in allergic-rhinitis treated with hydrogen-rich saline in guinea-pig model.",
      "title_en": null,
      "title_de": "Veränderungen der IL-4- und IL-13-Expression bei allergischer Rhinitis, behandelt mit wasserstoffreicher Kochsalzlösung im Meerschweinchenmodell",
      "journal": "Allergologia et immunopathologia",
      "authors": "Zhao et al.",
      "author_search": "zhao zhao",
      "doi": "10.1016/j.aller.2016.10.007",
      "doi_url": "https://doi.org/10.1016/j.aller.2016.10.007",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/28215576/",
      "url": "https://h2medicine.org/studies/study-zhao-2017-changes-expression-allergic-rhinitis/",
      "methods": [
        "saline-iv",
        "bath-topical"
      ],
      "indications": [
        "respiratory",
        "immune-system",
        "allergy"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "28189762",
      "year": 2017,
      "title": "A comprehensive computational study on pathogenic mis-sense mutations spanning the RING2 and REP domains of Parkin protein.",
      "title_en": null,
      "title_de": "Eine umfassende computergestützte Studie zu pathogenen Missense-Mutationen in den RING2- und REP-Domänen des Parkin-Proteins",
      "journal": "Gene",
      "authors": "Biswas et al.",
      "author_search": "biswas biswas",
      "doi": "10.1016/j.gene.2017.02.008",
      "doi_url": "https://doi.org/10.1016/j.gene.2017.02.008",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/28189762/",
      "url": "https://h2medicine.org/studies/study-biswas-2017-comprehensive-computational-pathogenic-mis/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "neurology"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "28148301",
      "year": 2017,
      "title": "Protective effects of molecular hydrogen on steroid-induced osteonecrosis in rabbits via reducing oxidative stress and apoptosis.",
      "title_en": null,
      "title_de": "Schützende Wirkungen von molekularem Wasserstoff auf die steroidinduzierte Osteonekrose bei Kaninchen durch Reduktion von oxidativem Stress und Apoptose",
      "journal": "BMC musculoskeletal disorders",
      "authors": "Li et al.",
      "author_search": "li li",
      "doi": "10.1186/s12891-017-1431-6",
      "doi_url": "https://doi.org/10.1186/s12891-017-1431-6",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/28148301/",
      "url": "https://h2medicine.org/studies/study-li-2017-protective-steroid-induced-osteonecrosis/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "metabolic",
        "cardiovascular",
        "joints-rheumatology",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "28087297",
      "year": 2017,
      "title": "Inhibition of streptococcal biofilm by hydrogen water.",
      "title_en": null,
      "title_de": "Hemmung von Streptokokken-Biofilm durch Wasserstoffwasser",
      "journal": "Journal of dentistry",
      "authors": "Kim et al.",
      "author_search": "kim kim",
      "doi": "10.1016/j.jdent.2017.01.004",
      "doi_url": "https://doi.org/10.1016/j.jdent.2017.01.004",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/28087297/",
      "url": "https://h2medicine.org/studies/study-kim-2017-inhibition-streptococcal-biofilm/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "oral-health",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "27965418",
      "year": 2017,
      "title": "Non-gut microbiota as a source of bioactive hydrogen.",
      "title_en": null,
      "title_de": "Nicht-Darm-Mikrobiota als Quelle bioaktiven Wasserstoffs",
      "journal": "Postgraduate medical journal",
      "authors": "Ostojic",
      "author_search": "ostojic ostojic",
      "doi": "10.1136/postgradmedj-2016-134411",
      "doi_url": "https://doi.org/10.1136/postgradmedj-2016-134411",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27965418/",
      "url": "https://h2medicine.org/studies/study-ostojic-2017-non-gut-microbiota-source/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "27780950",
      "year": 2017,
      "title": "Hydrogen Treatment Protects against Cell Death and Senescence Induced by Oxidative Damage.",
      "title_en": null,
      "title_de": "Wasserstoffbehandlung schützt vor Zelltod und Seneszenz, die durch oxidative Schädigung induziert werden",
      "journal": "Journal of microbiology and biotechnology",
      "authors": "Han et al.",
      "author_search": "han han",
      "doi": "10.4014/jmb.1608.08011",
      "doi_url": "https://doi.org/10.4014/jmb.1608.08011",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27780950/",
      "url": "https://h2medicine.org/studies/study-han-2017-protects-against-cell-death/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "skin-aging",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "27770674",
      "year": 2017,
      "title": "Evaluation of alkaline electrolyzed water to replace traditional phosphate enhancement solutions: Effects on water holding capacity, tenderness, and sensory characteristics.",
      "title_en": null,
      "title_de": "Bewertung von alkalisch-elektrolysiertem Wasser als Ersatz für traditionelle Phosphat-Verbesserungslösungen: Wirkungen auf Wasserbindungsvermögen, Zartheit und sensorische Eigenschaften",
      "journal": "Meat science",
      "authors": "Rigdon et al.",
      "author_search": "rigdon rigdon",
      "doi": "10.1016/j.meatsci.2016.10.007",
      "doi_url": "https://doi.org/10.1016/j.meatsci.2016.10.007",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27770674/",
      "url": "https://h2medicine.org/studies/study-rigdon-2017-alkaline-electrolyzed-replace-traditional/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "27777424",
      "year": 2016,
      "title": "The Clinical Application of Hydrogen as a Medical Treatment.",
      "title_en": null,
      "title_de": "Die klinische Anwendung von Wasserstoff als medizinische Behandlung",
      "journal": "Acta medica Okayama",
      "authors": "Iida et al.",
      "author_search": "iida iida",
      "doi": "10.18926/amo/54590",
      "doi_url": "https://doi.org/10.18926/amo/54590",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27777424/",
      "url": "https://h2medicine.org/studies/study-iida-2016-application-medical/",
      "methods": [
        "saline-iv",
        "drinking-hrw"
      ],
      "indications": [
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "27643933",
      "year": 2016,
      "title": "Preventive and therapeutic application of molecular hydrogen in situations with excessive production of free radicals.",
      "title_en": null,
      "title_de": "Präventive und therapeutische Anwendung von molekularem Wasserstoff bei Situationen mit übermäßiger Produktion freier Radikale",
      "journal": "Physiological research",
      "authors": "Slezák et al.",
      "author_search": "slezák slezák",
      "doi": "10.33549/physiolres.933414",
      "doi_url": "https://doi.org/10.33549/physiolres.933414",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27643933/",
      "url": "https://h2medicine.org/studies/study-slezak-2016-preventive-therapeutic-application-situations/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "27413421",
      "year": 2016,
      "title": "Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis.",
      "title_en": null,
      "title_de": "Therapie mit molekularem Wasserstoff mildert die durch Sepsis induzierte Organschädigung",
      "journal": "Oxidative medicine and cellular longevity",
      "authors": "Zheng et al.",
      "author_search": "zheng zheng",
      "doi": "10.1155/2016/5806057",
      "doi_url": "https://doi.org/10.1155/2016/5806057",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27413421/",
      "url": "https://h2medicine.org/studies/study-zheng-2016-ameliorates-organ-damage-induced/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "diabetes",
        "metabolic",
        "liver",
        "sports-exercise",
        "neurology",
        "cancer",
        "respiratory",
        "kidney-dialysis",
        "skin-aging",
        "joints-rheumatology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "27154268",
      "year": 2016,
      "title": "Rule of five in 2015 and beyond: Target and ligand structural limitations, ligand chemistry structure and drug discovery project decisions.",
      "title_en": null,
      "title_de": "Die Fünferregel 2015 und darüber hinaus: strukturelle Beschränkungen von Zielmolekül und Ligand, Ligandchemie-Struktur und Entscheidungen in Wirkstoffentdeckungsprojekten",
      "journal": "Advanced drug delivery reviews",
      "authors": "Lipinski",
      "author_search": "lipinski lipinski",
      "doi": "10.1016/j.addr.2016.04.029",
      "doi_url": "https://doi.org/10.1016/j.addr.2016.04.029",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27154268/",
      "url": "https://h2medicine.org/studies/study-lipinski-2016-rule-five-2015-beyond/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26642800",
      "year": 2016,
      "title": "Complementary therapies for bladder pain syndrome: a systematic review.",
      "title_en": null,
      "title_de": "Komplementäre Therapien beim Blasenschmerzsyndrom: eine systematische Übersichtsarbeit",
      "journal": "International urogynecology journal",
      "authors": "Verghese et al.",
      "author_search": "verghese verghese",
      "doi": "10.1007/s00192-015-2886-3",
      "doi_url": "https://doi.org/10.1007/s00192-015-2886-3",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26642800/",
      "url": "https://h2medicine.org/studies/study-verghese-2016-complementary-therapies-bladder-pain/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "27938540",
      "year": 2016,
      "title": "[Protective effect of hydrogen on the lung of sanitation workers exposed to haze].",
      "title_en": null,
      "title_de": "Schützende Wirkung von Wasserstoff auf die Lunge von Reinigungsarbeitern, die Smog ausgesetzt sind.",
      "journal": "Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases",
      "authors": "Gong et al.",
      "author_search": "gong gong",
      "doi": "10.3760/cma.j.issn.1001-0939.2016.12.003",
      "doi_url": "https://doi.org/10.3760/cma.j.issn.1001-0939.2016.12.003",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27938540/",
      "url": "https://h2medicine.org/studies/study-gong-2016-protective-lung-sanitation-workers/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "respiratory",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "27176725",
      "year": 2016,
      "title": "A randomized double-blind multi-center trial of hydrogen water for Parkinson's disease: protocol and baseline characteristics.",
      "title_en": null,
      "title_de": "Eine randomisierte doppelblinde multizentrische Studie zu Wasserstoffwasser bei Morbus Parkinson: Protokoll und Ausgangscharakteristika.",
      "journal": "BMC neurology",
      "authors": "Yoritaka et al.",
      "author_search": "yoritaka yoritaka",
      "doi": "10.1186/s12883-016-0589-0",
      "doi_url": "https://doi.org/10.1186/s12883-016-0589-0",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27176725/",
      "url": "https://h2medicine.org/studies/study-yoritaka-2016-multi-center-parkinson-disease/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "neurology"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "27606690",
      "year": 2016,
      "title": "Hydrogen-Rich Saline as an Innovative Therapy for Cataract: A Hypothesis.",
      "title_en": null,
      "title_de": "Wasserstoffreiche Kochsalzlösung als innovative Therapie bei Katarakt: Eine Hypothese",
      "journal": "Medical science monitor : international medical journal of experimental and clinical research",
      "authors": "Qin et al.",
      "author_search": "qin qin",
      "doi": "10.12659/msm.899807",
      "doi_url": "https://doi.org/10.12659/msm.899807",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27606690/",
      "url": "https://h2medicine.org/studies/study-qin-2016-saline-innovative-cataract-hypothesis/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "metabolic",
        "eye",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "27598129",
      "year": 2016,
      "title": "New Approach in Translational Medicine: Effects of Electrolyzed Reduced Water (ERW) on NF-κB/iNOS Pathway in U937 Cell Line under Altered Redox State.",
      "title_en": null,
      "title_de": "Neuer Ansatz in der translationalen Medizin: Wirkungen von elektrolysiertem reduziertem Wasser (ERW) auf den NF-κB/iNOS-Signalweg in der U937-Zelllinie bei verändertem Redox-Zustand",
      "journal": "International journal of molecular sciences",
      "authors": "Franceschelli et al.",
      "author_search": "franceschelli franceschelli",
      "doi": "10.3390/ijms17091461",
      "doi_url": "https://doi.org/10.3390/ijms17091461",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27598129/",
      "url": "https://h2medicine.org/studies/study-franceschelli-2016-approach-translational-medicine-electrolyzed/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "27558955",
      "year": 2016,
      "title": "Molecular hydrogen suppresses activated Wnt/β-catenin signaling.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff unterdrückt aktivierte Wnt/β-Catenin-Signalübertragung",
      "journal": "Scientific reports",
      "authors": "Lin et al.",
      "author_search": "lin lin",
      "doi": "10.1038/srep31986",
      "doi_url": "https://doi.org/10.1038/srep31986",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27558955/",
      "url": "https://h2medicine.org/studies/study-lin-2016-suppresses-activated-wnt-catenin/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "joints-rheumatology"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "27531909",
      "year": 2016,
      "title": "Hydrogen Metabolism in Helicobacter pylori Plays a Role in Gastric Carcinogenesis through Facilitating CagA Translocation.",
      "title_en": null,
      "title_de": "Der Wasserstoffstoffwechsel in Helicobacter pylori spielt eine Rolle bei der Magenkarzinogenese durch Erleichterung der CagA-Translokation",
      "journal": "mBio",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1128/mbio.01022-16",
      "doi_url": "https://doi.org/10.1128/mbio.01022-16",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27531909/",
      "url": "https://h2medicine.org/studies/study-wang-2016-metabolism-helicobacter-pylori-plays/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "liver",
        "sports-exercise",
        "cancer",
        "respiratory",
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "27477846",
      "year": 2016,
      "title": "Molecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff mildert zelluläre Seneszenz in Endothelzellen",
      "journal": "Circulation journal : official journal of the Japanese Circulation Society",
      "authors": "Hara et al.",
      "author_search": "hara hara",
      "doi": "10.1253/circj.cj-16-0227",
      "doi_url": "https://doi.org/10.1253/circj.cj-16-0227",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27477846/",
      "url": "https://h2medicine.org/studies/study-hara-2016-alleviates-cellular-senescence-endothelial/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "cardiovascular",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "27448107",
      "year": 2016,
      "title": "Molecular hydrogen in human breath: a new strategy for selectively diagnosing peptic ulcer disease, non-ulcerous dyspepsia and Helicobacter pylori infection.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff in der menschlichen Atemluft: eine neue Strategie zur selektiven Diagnose von peptischem Ulkus, nicht-ulzeröser Dyspepsie und Helicobacter-pylori-Infektion.",
      "journal": "Journal of breath research",
      "authors": "Maity et al.",
      "author_search": "maity maity",
      "doi": "10.1088/1752-7155/10/3/036007",
      "doi_url": "https://doi.org/10.1088/1752-7155/10/3/036007",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27448107/",
      "url": "https://h2medicine.org/studies/study-maity-2016-breath-strategy-selectively-diagnosing/",
      "methods": [],
      "indications": [
        "respiratory"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "27344261",
      "year": 2016,
      "title": "A revision in hydrogen isotopic composition of USGS42 and USGS43 human-hair stable isotopic reference materials for forensic science.",
      "title_en": null,
      "title_de": "Eine Revision der Wasserstoff-Isotopenzusammensetzung der stabilen Isotopen-Referenzmaterialien USGS42 und USGS43 aus menschlichem Haar für die forensische Wissenschaft",
      "journal": "Forensic science international",
      "authors": "Coplen et al.",
      "author_search": "coplen coplen",
      "doi": "10.1016/j.forsciint.2016.05.029",
      "doi_url": "https://doi.org/10.1016/j.forsciint.2016.05.029",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27344261/",
      "url": "https://h2medicine.org/studies/study-coplen-2016-revision-isotopic-composition-usgs42/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "27334126",
      "year": 2016,
      "title": "Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome　- First-in-Human Pilot Study.",
      "title_en": null,
      "title_de": "Durchführbarkeit und Sicherheit der Wasserstoffgas-Inhalation beim Post-Cardiac-Arrest-Syndrom — erste Pilotstudie am Menschen.",
      "journal": "Circulation journal : official journal of the Japanese Circulation Society",
      "authors": "Tamura et al.",
      "author_search": "tamura tamura",
      "doi": "10.1253/circj.cj-16-0127",
      "doi_url": "https://doi.org/10.1253/circj.cj-16-0127",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27334126/",
      "url": "https://h2medicine.org/studies/study-tamura-2016-feasibility-inhalation-post-cardiac/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "neurology",
        "fundamentals-safety"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "27123663",
      "year": 2016,
      "title": "H2 metabolism is widespread and diverse among human colonic microbes.",
      "title_en": null,
      "title_de": "Der H₂-Metabolismus ist unter menschlichen Kolonmikroben weit verbreitet und vielfältig",
      "journal": "Gut microbes",
      "authors": "Wolf et al.",
      "author_search": "wolf wolf",
      "doi": "10.1080/19490976.2016.1182288",
      "doi_url": "https://doi.org/10.1080/19490976.2016.1182288",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27123663/",
      "url": "https://h2medicine.org/studies/study-wolf-2016-metabolism-widespread-diverse-among/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "metabolic",
        "sports-exercise",
        "eye",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26947809",
      "year": 2016,
      "title": "Dock 'n roll: folding of a silk-inspired polypeptide into an amyloid-like beta solenoid.",
      "title_en": null,
      "title_de": "Dock 'n roll: Faltung eines seiden-inspirierten Polypeptids in ein amyloidähnliches Beta-Solenoid",
      "journal": "Soft matter",
      "authors": "Zhao et al.",
      "author_search": "zhao zhao",
      "doi": "10.1039/c6sm00169f",
      "doi_url": "https://doi.org/10.1039/c6sm00169f",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26947809/",
      "url": "https://h2medicine.org/studies/study-zhao-2016-dock-roll-folding-silk/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26927488",
      "year": 2016,
      "title": "Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents.",
      "title_en": null,
      "title_de": "Entdeckung neuartiger 2-Phenyl-imidazo[1,2-a]pyridin-Analoga, die auf die Tubulin-Polymerisation als antiproliferative Wirkstoffe abzielen",
      "journal": "European journal of medicinal chemistry",
      "authors": "An et al.",
      "author_search": "an an",
      "doi": "10.1016/j.ejmech.2016.02.004",
      "doi_url": "https://doi.org/10.1016/j.ejmech.2016.02.004",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26927488/",
      "url": "https://h2medicine.org/studies/study-an-2016-discovery-phenyl-imidazo-pyridine/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "29917336",
      "year": 2016,
      "title": "[Effects of hydrogen-rich medium on lipopolysaccharide-induced intestinal epithelial barrier dysfunction of human colon carcinoma cells].",
      "title_en": null,
      "title_de": "Wirkungen von wasserstoffreichem Medium auf die lipopolysaccharid-induzierte Funktionsstörung der intestinalen Epithelbarriere menschlicher Kolonkarzinomzellen",
      "journal": "Zhonghua wei zhong bing ji jiu yi xue",
      "authors": "Yang et al.",
      "author_search": "yang yang",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29917336/",
      "url": "https://h2medicine.org/studies/study-yang-2016-medium-lipopolysaccharide-induced-intestinal/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "cancer",
        "pregnancy"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26912054",
      "year": 2016,
      "title": "Optically-Induced Cell Fusion on Cell Pairing Microstructures.",
      "title_en": null,
      "title_de": "Optisch induzierte Zellfusion auf Zellpaarungs-Mikrostrukturen",
      "journal": "Scientific reports",
      "authors": "Yang et al.",
      "author_search": "yang yang",
      "doi": "10.1038/srep22036",
      "doi_url": "https://doi.org/10.1038/srep22036",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26912054/",
      "url": "https://h2medicine.org/studies/study-yang-2016-optically-induced-cell-fusion/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26845501",
      "year": 2016,
      "title": "Hydrogen-rich water ameliorates bronchopulmonary dysplasia (BPD) in newborn rats.",
      "title_en": null,
      "title_de": "Wasserstoffreiches Wasser mildert die bronchopulmonale Dysplasie (BPD) bei neugeborenen Ratten",
      "journal": "Pediatric pulmonology",
      "authors": "Muramatsu et al.",
      "author_search": "muramatsu muramatsu",
      "doi": "10.1002/ppul.23386",
      "doi_url": "https://doi.org/10.1002/ppul.23386",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26845501/",
      "url": "https://h2medicine.org/studies/study-muramatsu-2016-ameliorates-bronchopulmonary-dysplasia-bpd/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "cancer",
        "respiratory",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26777153",
      "year": 2016,
      "title": "How the imidazole ring modulates amyloid formation of islet amyloid polypeptide: A chemical modification study.",
      "title_en": null,
      "title_de": "Wie der Imidazolring die Amyloidbildung des Inselamyloid-Polypeptids moduliert: Eine chemische Modifikationsstudie",
      "journal": "Biochimica et biophysica acta",
      "authors": "Zhang et al.",
      "author_search": "zhang zhang",
      "doi": "10.1016/j.bbagen.2016.01.008",
      "doi_url": "https://doi.org/10.1016/j.bbagen.2016.01.008",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26777153/",
      "url": "https://h2medicine.org/studies/study-zhang-2016-how-imidazole-ring-modulates/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "diabetes"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26739257",
      "year": 2016,
      "title": "Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff reguliert die Genexpression durch Modifikation der von der Radikalkettenreaktion abhängigen Erzeugung oxidierter Phospholipid-Mediatoren",
      "journal": "Scientific reports",
      "authors": "Iuchi et al.",
      "author_search": "iuchi iuchi",
      "doi": "10.1038/srep18971",
      "doi_url": "https://doi.org/10.1038/srep18971",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26739257/",
      "url": "https://h2medicine.org/studies/study-iuchi-2016-regulates-gene-expression-modifying/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "metabolic",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26714124",
      "year": 2016,
      "title": "Hydrogen-Rich Saline Attenuates Acute Kidney Injury After Liver Transplantation via Activating p53-Mediated Autophagy.",
      "title_en": null,
      "title_de": "Wasserstoffreiche Kochsalzlösung mildert akute Nierenschädigung nach Lebertransplantation durch Aktivierung der p53-vermittelten Autophagie",
      "journal": "Transplantation",
      "authors": "Du et al.",
      "author_search": "du du",
      "doi": "10.1097/tp.0000000000001052",
      "doi_url": "https://doi.org/10.1097/tp.0000000000001052",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26714124/",
      "url": "https://h2medicine.org/studies/study-du-2016-saline-attenuates-acute-kidney/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "liver",
        "kidney-dialysis",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26657415",
      "year": 2016,
      "title": "Is melanin a source of bioactive molecular hydrogen?",
      "title_en": null,
      "title_de": "Ist Melanin eine Quelle bioaktiven molekularen Wasserstoffs?",
      "journal": "Pharmacological research",
      "authors": "Ostojic et al.",
      "author_search": "ostojic ostojic",
      "doi": "10.1016/j.phrs.2015.12.002",
      "doi_url": "https://doi.org/10.1016/j.phrs.2015.12.002",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26657415/",
      "url": "https://h2medicine.org/studies/study-ostojic-2016-melanin-source-bioactive/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26631313",
      "year": 2016,
      "title": "Design and optimization of selective azaindole amide M1 positive allosteric modulators.",
      "title_en": null,
      "title_de": "Design und Optimierung selektiver Azaindolamid-M1-positiver allosterischer Modulatoren",
      "journal": "Bioorganic & medicinal chemistry letters",
      "authors": "Davoren et al.",
      "author_search": "davoren davoren",
      "doi": "10.1016/j.bmcl.2015.11.053",
      "doi_url": "https://doi.org/10.1016/j.bmcl.2015.11.053",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26631313/",
      "url": "https://h2medicine.org/studies/study-davoren-2016-design-optimization-selective-azaindole/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "neurology",
        "fundamentals-safety"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26537817",
      "year": 2016,
      "title": "Treatment with Hydrogen-Rich Saline Delays Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis.",
      "title_en": null,
      "title_de": "Behandlung mit wasserstoffreicher Kochsalzlösung verzögert das Fortschreiten der Erkrankung in einem Mausmodell der amyotrophen Lateralsklerose",
      "journal": "Neurochemical research",
      "authors": "Zhang et al.",
      "author_search": "zhang zhang",
      "doi": "10.1007/s11064-015-1750-7",
      "doi_url": "https://doi.org/10.1007/s11064-015-1750-7",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26537817/",
      "url": "https://h2medicine.org/studies/study-zhang-2016-saline-delays-disease-progression/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "neurology",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26529665",
      "year": 2016,
      "title": "HYDROGEN-RICH MEDIUM AMELIORATES LIPOPOLYSACCHARIDE-INDUCED BARRIER DYSFUNCTION VIA RHOA-MDIA1 SIGNALING IN CACO-2 CELLS.",
      "title_en": null,
      "title_de": "Wasserstoffreiches Medium mildert die lipopolysaccharid-induzierte Barrierefunktionsstörung über die RhoA-mDia1-Signalübertragung in Caco-2-Zellen",
      "journal": "Shock (Augusta, Ga.)",
      "authors": "Yang et al.",
      "author_search": "yang yang",
      "doi": "10.1097/shk.0000000000000503",
      "doi_url": "https://doi.org/10.1097/shk.0000000000000503",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26529665/",
      "url": "https://h2medicine.org/studies/study-yang-2016-medium-ameliorates-lipopolysaccharide-induced/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26012504",
      "year": 2016,
      "title": "Antioxidants and K+ channel agonists versus hydrogen therapy during ex vivo lung perfusion†.",
      "title_en": null,
      "title_de": "Antioxidantien und K⁺-Kanal-Agonisten versus Wasserstofftherapie während der Ex-vivo-Lungenperfusion",
      "journal": "European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery",
      "authors": "Mohamed",
      "author_search": "mohamed mohamed",
      "doi": "10.1093/ejcts/ezv192",
      "doi_url": "https://doi.org/10.1093/ejcts/ezv192",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26012504/",
      "url": "https://h2medicine.org/studies/study-mohamed-2016-antioxidants-channel-agonists-versus/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "respiratory",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "25671669",
      "year": 2016,
      "title": "Multi-drug resistance profile of PR20 HIV-1 protease is attributed to distorted conformational and drug binding landscape: molecular dynamics insights.",
      "title_en": null,
      "title_de": "Das Multiresistenzprofil der PR20-HIV-1-Protease wird einer verzerrten Konformations- und Wirkstoffbindungslandschaft zugeschrieben: Erkenntnisse aus der Molekulardynamik",
      "journal": "Journal of biomolecular structure & dynamics",
      "authors": "Chetty et al.",
      "author_search": "chetty chetty",
      "doi": "10.1080/07391102.2015.1018326",
      "doi_url": "https://doi.org/10.1080/07391102.2015.1018326",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25671669/",
      "url": "https://h2medicine.org/studies/study-chetty-2016-multi-drug-resistance-profile/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26571560",
      "year": 2015,
      "title": "[Initiation, development and potential of hydrogen medicine: Toward therapeutic and preventive applications of molecular hydrogen against a variety of diseases].",
      "title_en": null,
      "title_de": "Anfänge, Entwicklung und Potenzial der Wasserstoffmedizin: Auf dem Weg zu therapeutischen und präventiven Anwendungen von molekularem Wasserstoff gegen eine Vielzahl von Erkrankungen",
      "journal": "Seikagaku. The Journal of Japanese Biochemical Society",
      "authors": "Ohta",
      "author_search": "ohta ohta",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26571560/",
      "url": "https://h2medicine.org/studies/study-ohta-2015-initiation-development-medicine-toward/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "26337845",
      "year": 2015,
      "title": "Direct Interspecies Electron Transfer in Anaerobic Digestion: A Review.",
      "title_en": null,
      "title_de": "Direkter Interspezies-Elektronentransfer in der anaeroben Vergärung: Eine Übersichtsarbeit",
      "journal": "Advances in biochemical engineering/biotechnology",
      "authors": "Dubé et al.",
      "author_search": "dubé dubé",
      "doi": "10.1007/978-3-319-21993-6_4",
      "doi_url": "https://doi.org/10.1007/978-3-319-21993-6_4",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26337845/",
      "url": "https://h2medicine.org/studies/study-dube-2015-direct-interspecies-electron-transfer/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "25958185",
      "year": 2015,
      "title": "Chemical communication in the gut: Effects of microbiota-generated metabolites on gastrointestinal bacterial pathogens.",
      "title_en": null,
      "title_de": "Chemische Kommunikation im Darm: Wirkungen von mikrobiota-erzeugten Metaboliten auf gastrointestinale bakterielle Pathogene.",
      "journal": "Anaerobe",
      "authors": "Vogt et al.",
      "author_search": "vogt vogt",
      "doi": "10.1016/j.anaerobe.2015.05.002",
      "doi_url": "https://doi.org/10.1016/j.anaerobe.2015.05.002",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25958185/",
      "url": "https://h2medicine.org/studies/study-vogt-2015-chemical-communication-gut-microbiota/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "25936365",
      "year": 2015,
      "title": "Molecular hydrogen: An inert gas turns clinically effective.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff: Ein inertes Gas wird klinisch wirksam.",
      "journal": "Annals of medicine",
      "authors": "Ostojic",
      "author_search": "ostojic ostojic",
      "doi": "10.3109/07853890.2015.1034765",
      "doi_url": "https://doi.org/10.3109/07853890.2015.1034765",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25936365/",
      "url": "https://h2medicine.org/studies/study-ostojic-2015-inert-turns-clinically-effective/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "immune-system"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "25747486",
      "year": 2015,
      "title": "Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff als neuartiges Antioxidans: Überblick über die Vorteile von Wasserstoff für medizinische Anwendungen.",
      "journal": "Methods in enzymology",
      "authors": "Ohta",
      "author_search": "ohta ohta",
      "doi": "10.1016/bs.mie.2014.11.038",
      "doi_url": "https://doi.org/10.1016/bs.mie.2014.11.038",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25747486/",
      "url": "https://h2medicine.org/studies/study-ohta-2015-antioxidant-overview-advantages-medical/",
      "methods": [
        "inhalation",
        "saline-iv",
        "bath-topical",
        "drinking-hrw"
      ],
      "indications": [
        "eye",
        "immune-system",
        "allergy",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "25720951",
      "year": 2015,
      "title": "Targeting molecular hydrogen to mitochondria: barriers and gateways.",
      "title_en": null,
      "title_de": "Gezielte Ausrichtung von molekularem Wasserstoff an Mitochondrien: Barrieren und Zugangswege.",
      "journal": "Pharmacological research",
      "authors": "Ostojic",
      "author_search": "ostojic ostojic",
      "doi": "10.1016/j.phrs.2015.02.004",
      "doi_url": "https://doi.org/10.1016/j.phrs.2015.02.004",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25720951/",
      "url": "https://h2medicine.org/studies/study-ostojic-2015-targeting-mitochondria-barriers-gateways/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver",
        "sports-exercise"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "25525953",
      "year": 2015,
      "title": "Molecular hydrogen in sports medicine: new therapeutic perspectives.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff in der Sportmedizin: neue therapeutische Perspektiven.",
      "journal": "International journal of sports medicine",
      "authors": "Ostojic",
      "author_search": "ostojic ostojic",
      "doi": "10.1055/s-0034-1395509",
      "doi_url": "https://doi.org/10.1055/s-0034-1395509",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25525953/",
      "url": "https://h2medicine.org/studies/study-ostojic-2015-sports-medicine-therapeutic-perspectives/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "diabetes",
        "sports-exercise",
        "neurology",
        "joints-rheumatology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "25413928",
      "year": 2015,
      "title": "Radiation occupational health interventions offered to radiation workers in response to the complex catastrophic disaster at the Fukushima Daiichi Nuclear Power Plant.",
      "title_en": null,
      "title_de": "Strahlenschutz-arbeitsmedizinische Maßnahmen für Strahlenarbeiter als Reaktion auf die komplexe katastrophale Havarie im Kernkraftwerk Fukushima Daiichi.",
      "journal": "Journal of radiation research",
      "authors": "Shimura et al.",
      "author_search": "shimura shimura",
      "doi": "10.1093/jrr/rru110",
      "doi_url": "https://doi.org/10.1093/jrr/rru110",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25413928/",
      "url": "https://h2medicine.org/studies/study-shimura-2015-radiation-occupational-health-interventions/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cancer",
        "skin-aging"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "24754449",
      "year": 2015,
      "title": "Advances in the biotechnology of hydrogen production with the microalga Chlamydomonas reinhardtii.",
      "title_en": null,
      "title_de": "Fortschritte in der Biotechnologie der Wasserstoffproduktion mit der Mikroalge Chlamydomonas reinhardtii.",
      "journal": "Critical reviews in biotechnology",
      "authors": "Torzillo et al.",
      "author_search": "torzillo torzillo",
      "doi": "10.3109/07388551.2014.900734",
      "doi_url": "https://doi.org/10.3109/07388551.2014.900734",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/24754449/",
      "url": "https://h2medicine.org/studies/study-torzillo-2015-advances-biotechnology-production-microalga/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "26596710",
      "year": 2015,
      "title": "Discovery of novel quinoline-based mTOR inhibitors via introducing intra-molecular hydrogen bonding scaffold (iMHBS): The design, synthesis and biological evaluation.",
      "title_en": null,
      "title_de": "Entdeckung neuartiger chinolinbasierter mTOR-Inhibitoren durch Einführung eines intramolekularen Wasserstoffbrücken-Gerüsts (iMHBS): Design, Synthese und biologische Bewertung.",
      "journal": "Bioorganic & medicinal chemistry",
      "authors": "Ma et al.",
      "author_search": "ma ma",
      "doi": "10.1016/j.bmc.2015.11.003",
      "doi_url": "https://doi.org/10.1016/j.bmc.2015.11.003",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26596710/",
      "url": "https://h2medicine.org/studies/study-ma-2015-discovery-quinoline-mtor-inhibitors/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26271894",
      "year": 2015,
      "title": "Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells.",
      "title_en": null,
      "title_de": "Wasserstoffreiches Wasser mildert die durch Amyloid-β induzierte Zytotoxizität durch Hochregulation von Sirt1-FoxO3a über die Stimulation der AMP-aktivierten Proteinkinase in SK-N-MC-Zellen.",
      "journal": "Chemico-biological interactions",
      "authors": "Lin et al.",
      "author_search": "lin lin",
      "doi": "10.1016/j.cbi.2015.07.013",
      "doi_url": "https://doi.org/10.1016/j.cbi.2015.07.013",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26271894/",
      "url": "https://h2medicine.org/studies/study-lin-2015-attenuates-amyloid-induced-cytotoxicity/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "neurology",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26253656",
      "year": 2015,
      "title": "Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial dysfunction via an Nrf2/HO-1 signaling pathway.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff schützt Mäuse vor polymikrobieller Sepsis durch Milderung der Endotheldysfunktion über einen Nrf2/HO-1-Signalweg.",
      "journal": "International immunopharmacology",
      "authors": "Chen et al.",
      "author_search": "chen chen",
      "doi": "10.1016/j.intimp.2015.07.034",
      "doi_url": "https://doi.org/10.1016/j.intimp.2015.07.034",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26253656/",
      "url": "https://h2medicine.org/studies/study-chen-2015-protects-mice-against-polymicrobial/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cardiovascular",
        "cancer",
        "respiratory",
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26125821",
      "year": 2015,
      "title": "Protective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and vascular endothelial permeability through regulation of vascular endothelial cadherin.",
      "title_en": null,
      "title_de": "Schützende Wirkungen von wasserstoffreichem Medium auf die lipopolysaccharid-induzierte monozytäre Adhäsion und die Permeabilität des Gefäßendothels durch Regulation des vaskulären endothelialen Cadherins.",
      "journal": "Genetics and molecular research : GMR",
      "authors": "Yu et al.",
      "author_search": "yu yu",
      "doi": "10.4238/2015.june.9.6",
      "doi_url": "https://doi.org/10.4238/2015.june.9.6",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26125821/",
      "url": "https://h2medicine.org/studies/study-yu-2015-protective-medium-lipopolysaccharide-induced/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cardiovascular",
        "joints-rheumatology"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26117323",
      "year": 2015,
      "title": "Molecular hydrogen stabilizes atherosclerotic plaque in low-density lipoprotein receptor-knockout mice.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff stabilisiert atherosklerotische Plaque in Low-Density-Lipoprotein-Rezeptor-Knockout-Mäusen.",
      "journal": "Free radical biology & medicine",
      "authors": "Song et al.",
      "author_search": "song song",
      "doi": "10.1016/j.freeradbiomed.2015.06.018",
      "doi_url": "https://doi.org/10.1016/j.freeradbiomed.2015.06.018",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26117323/",
      "url": "https://h2medicine.org/studies/study-song-2015-stabilizes-atherosclerotic-plaque-low/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "metabolic",
        "cardiovascular",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26077945",
      "year": 2015,
      "title": "Effect of T68A/N126Y mutations on the conformational and ligand binding landscape of Coxsackievirus B3 3C protease.",
      "title_en": null,
      "title_de": "Wirkung der T68A/N126Y-Mutationen auf die Konformations- und Ligandenbindungslandschaft der Coxsackievirus-B3-3C-Protease.",
      "journal": "Molecular bioSystems",
      "authors": "Bhakat",
      "author_search": "bhakat bhakat",
      "doi": "10.1039/c5mb00262a",
      "doi_url": "https://doi.org/10.1039/c5mb00262a",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26077945/",
      "url": "https://h2medicine.org/studies/study-bhakat-2015-t68a-n126y-mutations-conformational/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26028929",
      "year": 2015,
      "title": "Determination of rifaximin treatment period according to lactulose breath test values in nonconstipated irritable bowel syndrome subjects.",
      "title_en": null,
      "title_de": "Bestimmung der Rifaximin-Behandlungsdauer anhand von Laktulose-Atemtestwerten bei nicht-obstipierten Reizdarmsyndrom-Probanden.",
      "journal": "Journal of Korean medical science",
      "authors": "Bae et al.",
      "author_search": "bae bae",
      "doi": "10.3346/jkms.2015.30.6.757",
      "doi_url": "https://doi.org/10.3346/jkms.2015.30.6.757",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26028929/",
      "url": "https://h2medicine.org/studies/study-bae-2015-determination-rifaximin-period-according/",
      "methods": [],
      "indications": [
        "other"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "26011121",
      "year": 2015,
      "title": "Atomic Insight into the Altered O6-Methylguanine-DNA Methyltransferase Protein Architecture in Gastric Cancer.",
      "title_en": null,
      "title_de": "Atomarer Einblick in die veränderte Proteinarchitektur der O6-Methylguanin-DNA-Methyltransferase bei Magenkrebs.",
      "journal": "PloS one",
      "authors": "Chikan et al.",
      "author_search": "chikan chikan",
      "doi": "10.1371/journal.pone.0127741",
      "doi_url": "https://doi.org/10.1371/journal.pone.0127741",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26011121/",
      "url": "https://h2medicine.org/studies/study-chikan-2015-atomic-insight-altered-methylguanine/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise",
        "neurology",
        "cancer"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26009165",
      "year": 2015,
      "title": "Michael acceptor in gambogic acid--Its role and application for potent antitumor agents.",
      "title_en": null,
      "title_de": "Michael-Akzeptor in Gambogasäure — seine Rolle und Anwendung für potente Antitumor-Wirkstoffe.",
      "journal": "Bioorganic & medicinal chemistry letters",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1016/j.bmcl.2015.04.100",
      "doi_url": "https://doi.org/10.1016/j.bmcl.2015.04.100",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26009165/",
      "url": "https://h2medicine.org/studies/study-wang-2015-michael-acceptor-gambogic-acid/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "25962664",
      "year": 2015,
      "title": "Hydrogen gas production is associated with reduced interleukin-1β mRNA in peripheral blood after a single dose of acarbose in Japanese type 2 diabetic patients.",
      "title_en": null,
      "title_de": "Die Wasserstoffgasproduktion ist mit reduzierter Interleukin-1β-mRNA im peripheren Blut nach einer Einzeldosis Acarbose bei japanischen Typ-2-Diabetespatienten assoziiert.",
      "journal": "European journal of pharmacology",
      "authors": "Tamasawa et al.",
      "author_search": "tamasawa tamasawa",
      "doi": "10.1016/j.ejphar.2015.04.051",
      "doi_url": "https://doi.org/10.1016/j.ejphar.2015.04.051",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25962664/",
      "url": "https://h2medicine.org/studies/study-tamasawa-2015-production-associated-reduced-interleukin/",
      "methods": [],
      "indications": [
        "diabetes",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "byproduct"
    },
    {
      "pmid": "25947958",
      "year": 2015,
      "title": "Maternal molecular hydrogen treatment attenuates lipopolysaccharide-induced rat fetal lung injury.",
      "title_en": null,
      "title_de": "Mütterliche Behandlung mit molekularem Wasserstoff mildert die lipopolysaccharid-induzierte fetale Lungenschädigung bei Ratten.",
      "journal": "Free radical research",
      "authors": "Hattori et al.",
      "author_search": "hattori hattori",
      "doi": "10.3109/10715762.2015.1038257",
      "doi_url": "https://doi.org/10.3109/10715762.2015.1038257",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25947958/",
      "url": "https://h2medicine.org/studies/study-hattori-2015-maternal-attenuates-lipopolysaccharide-induced/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "cardiovascular",
        "respiratory",
        "immune-system",
        "pregnancy",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "25936373",
      "year": 2015,
      "title": "Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases.",
      "title_en": null,
      "title_de": "Verbesserung der psoriasis-assoziierten Arthritis und Hautläsionen durch Behandlung mit molekularem Wasserstoff: Ein Bericht über drei Fälle.",
      "journal": "Molecular medicine reports",
      "authors": "Ishibashi et al.",
      "author_search": "ishibashi ishibashi",
      "doi": "10.3892/mmr.2015.3707",
      "doi_url": "https://doi.org/10.3892/mmr.2015.3707",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25936373/",
      "url": "https://h2medicine.org/studies/study-ishibashi-2015-improvement-psoriasis-associated-arthritis/",
      "methods": [
        "inhalation",
        "saline-iv",
        "drinking-hrw"
      ],
      "indications": [
        "cancer",
        "skin-aging",
        "joints-rheumatology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "25920542",
      "year": 2015,
      "title": "Eumelanin-driven production of molecular hydrogen: A novel element of skin defense?",
      "title_en": null,
      "title_de": "Eumelanin-gesteuerte Produktion von molekularem Wasserstoff: ein neues Element der Hautabwehr?",
      "journal": "Medical hypotheses",
      "authors": "Ostojic",
      "author_search": "ostojic ostojic",
      "doi": "10.1016/j.mehy.2015.04.014",
      "doi_url": "https://doi.org/10.1016/j.mehy.2015.04.014",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25920542/",
      "url": "https://h2medicine.org/studies/study-ostojic-2015-eumelanin-driven-production-element/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "skin-aging",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "25895142",
      "year": 2015,
      "title": "Hydrogen-Rich Medium Attenuated Lipopolysaccharide-Induced Monocyte-Endothelial Cell Adhesion and Vascular Endothelial Permeability via Rho-Associated Coiled-Coil Protein Kinase.",
      "title_en": null,
      "title_de": "Wasserstoffreiches Medium schwächte die Lipopolysaccharid-induzierte Monozyten-Endothelzell-Adhäsion und die vaskuläre Endothelpermeabilität über die Rho-assoziierte Coiled-Coil-Proteinkinase ab.",
      "journal": "Shock (Augusta, Ga.)",
      "authors": "Xie et al.",
      "author_search": "xie xie",
      "doi": "10.1097/shk.0000000000000365",
      "doi_url": "https://doi.org/10.1097/shk.0000000000000365",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25895142/",
      "url": "https://h2medicine.org/studies/study-xie-2015-medium-attenuated-lipopolysaccharide-induced/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cardiovascular",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "25812363",
      "year": 2015,
      "title": "[Alpha-glucosidase inhibitor].",
      "title_en": null,
      "title_de": "[Alpha-Glucosidase-Hemmer]. (Nihon Rinsho)",
      "journal": "Nihon rinsho. Japanese journal of clinical medicine",
      "authors": "Osonoi",
      "author_search": "osonoi osonoi",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25812363/",
      "url": "https://h2medicine.org/studies/study-osonoi-2015-alpha-glucosidase-inhibitor/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "cardiovascular"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "25800452",
      "year": 2015,
      "title": "Hydrogen Therapy Reduces Oxidative Stress-associated Risks Following Acute and Chronic Exposure to High-altitude Environment.",
      "title_en": null,
      "title_de": "Wasserstofftherapie reduziert mit oxidativem Stress assoziierte Risiken nach akuter und chronischer Exposition gegenüber einer Höhenumgebung.",
      "journal": "Biomedical and environmental sciences : BES",
      "authors": "Shi et al.",
      "author_search": "shi shi",
      "doi": "10.3967/bes2015.034",
      "doi_url": "https://doi.org/10.3967/bes2015.034",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25800452/",
      "url": "https://h2medicine.org/studies/study-shi-2015-reduces-oxidative-stress-associated/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "cancer",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "25767993",
      "year": 2015,
      "title": "Synthesis, spectral characterization, thermal behaviour, antibacterial activity and DFT calculation on N'-[bis(methylsulfanyl) methylene]-2-hydroxybenzohydrazide and N'-(4-methoxy benzoyl)-hydrazinecarbodithioic acid ethyl ester.",
      "title_en": null,
      "title_de": "Synthese, spektrale Charakterisierung, thermisches Verhalten, antibakterielle Aktivität und DFT-Berechnung an N'-[Bis(methylsulfanyl)methylen]-2-hydroxybenzohydrazid und N'-(4-Methoxybenzoyl)-hydrazincarbodithionsäure-ethylester.",
      "journal": "Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy",
      "authors": "Bharty et al.",
      "author_search": "bharty bharty",
      "doi": "10.1016/j.saa.2015.02.055",
      "doi_url": "https://doi.org/10.1016/j.saa.2015.02.055",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25767993/",
      "url": "https://h2medicine.org/studies/study-bharty-2015-synthesis-spectral-characterization-thermal/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "25758062",
      "year": 2015,
      "title": "Prediction of binding modes between protein L-isoaspartyl (D-aspartyl) O-methyltransferase and peptide substrates including isomerized aspartic acid residues using in silico analytic methods for the substrate screening.",
      "title_en": null,
      "title_de": "Vorhersage der Bindungsmodi zwischen Protein-L-Isoaspartyl-(D-Aspartyl)-O-Methyltransferase und Peptidsubstraten mit isomerisierten Asparaginsäureresten unter Verwendung von In-silico-Analysemethoden für das Substrat-Screening.",
      "journal": "Journal of pharmaceutical and biomedical analysis",
      "authors": "Oda et al.",
      "author_search": "oda oda",
      "doi": "10.1016/j.jpba.2015.02.030",
      "doi_url": "https://doi.org/10.1016/j.jpba.2015.02.030",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25758062/",
      "url": "https://h2medicine.org/studies/study-oda-2015-prediction-binding-modes-between/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "25708582",
      "year": 2015,
      "title": "Diversity of human-associated Methanobrevibacter smithii isolates revealed by multispacer sequence typing.",
      "title_en": null,
      "title_de": "Diversität von mit dem Menschen assoziierten Methanobrevibacter-smithii-Isolaten, aufgedeckt durch Multispacer-Sequenztypisierung.",
      "journal": "Current microbiology",
      "authors": "Nkamga et al.",
      "author_search": "nkamga nkamga",
      "doi": "10.1007/s00284-015-0787-9",
      "doi_url": "https://doi.org/10.1007/s00284-015-0787-9",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25708582/",
      "url": "https://h2medicine.org/studies/study-nkamga-2015-diversity-associated-methanobrevibacter-smithii/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "25681223",
      "year": 2015,
      "title": "Effects of vitamin C, vitamin E, and molecular hydrogen on the placental function in trophoblast cells.",
      "title_en": null,
      "title_de": "Wirkungen von Vitamin C, Vitamin E und molekularem Wasserstoff auf die Plazentafunktion in Trophoblastenzellen.",
      "journal": "Archives of gynecology and obstetrics",
      "authors": "Guan et al.",
      "author_search": "guan guan",
      "doi": "10.1007/s00404-015-3647-8",
      "doi_url": "https://doi.org/10.1007/s00404-015-3647-8",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25681223/",
      "url": "https://h2medicine.org/studies/study-guan-2015-vitamin-vitamin-placental-function/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "pregnancy",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "25468479",
      "year": 2015,
      "title": "Can an innocent toy become dangerous? The hydrogen gas balloon burn.",
      "title_en": null,
      "title_de": "Kann ein harmloses Spielzeug gefährlich werden? Die Wasserstoffgasballon-Verbrennung.",
      "journal": "Burns : journal of the International Society for Burn Injuries",
      "authors": "Keles et al.",
      "author_search": "keles keles",
      "doi": "10.1016/j.burns.2014.10.011",
      "doi_url": "https://doi.org/10.1016/j.burns.2014.10.011",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25468479/",
      "url": "https://h2medicine.org/studies/study-keles-2015-can-innocent-toy-become/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "25446368",
      "year": 2015,
      "title": "The use of hydrogen gas clearance for blood flow measurements in single endogenous and transplanted pancreatic islets.",
      "title_en": null,
      "title_de": "Die Verwendung der Wasserstoffgas-Clearance zur Messung des Blutflusses in einzelnen endogenen und transplantierten Pankreasinseln.",
      "journal": "Microvascular research",
      "authors": "Barbu et al.",
      "author_search": "barbu barbu",
      "doi": "10.1016/j.mvr.2014.10.002",
      "doi_url": "https://doi.org/10.1016/j.mvr.2014.10.002",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25446368/",
      "url": "https://h2medicine.org/studies/study-barbu-2015-use-clearance-blood-flow/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cardiovascular",
        "kidney-dialysis"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "25411171",
      "year": 2015,
      "title": "Campylobacter concisus pseudo-outbreak caused by improved culture conditions.",
      "title_en": null,
      "title_de": "Campylobacter-concisus-Pseudoausbruch verursacht durch verbesserte Kulturbedingungen.",
      "journal": "Journal of clinical microbiology",
      "authors": "Casanova et al.",
      "author_search": "casanova casanova",
      "doi": "10.1128/jcm.02608-14",
      "doi_url": "https://doi.org/10.1128/jcm.02608-14",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25411171/",
      "url": "https://h2medicine.org/studies/study-casanova-2015-campylobacter-concisus-pseudo-outbreak/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "24829918",
      "year": 2014,
      "title": "Hydrogen gas presents a promising therapeutic strategy for sepsis.",
      "title_en": null,
      "title_de": "Wasserstoffgas stellt eine vielversprechende therapeutische Strategie für Sepsis dar.",
      "journal": "BioMed research international",
      "authors": "Xie et al.",
      "author_search": "xie xie",
      "doi": "10.1155/2014/807635",
      "doi_url": "https://doi.org/10.1155/2014/807635",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/24829918/",
      "url": "https://h2medicine.org/studies/study-xie-2014-presents-promising-therapeutic-strategy/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "24769081",
      "year": 2014,
      "title": "Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff als präventives und therapeutisches medizinisches Gas: Beginn, Entwicklung und Potenzial der Wasserstoffmedizin.",
      "journal": "Pharmacology & therapeutics",
      "authors": "Ohta",
      "author_search": "ohta ohta",
      "doi": "10.1016/j.pharmthera.2014.04.006",
      "doi_url": "https://doi.org/10.1016/j.pharmthera.2014.04.006",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/24769081/",
      "url": "https://h2medicine.org/studies/study-ohta-2014-preventive-therapeutic-medical-initiation/",
      "methods": [
        "inhalation",
        "saline-iv",
        "bath-topical",
        "drinking-hrw"
      ],
      "indications": [
        "eye",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "24532027",
      "year": 2014,
      "title": "Novel therapeutic strategies for traumatic brain injury: acute antioxidant reinforcement.",
      "title_en": null,
      "title_de": "Neuartige therapeutische Strategien für das Schädel-Hirn-Trauma: akute antioxidative Verstärkung.",
      "journal": "CNS drugs",
      "authors": "Fernández-Gajardo et al.",
      "author_search": "fernández-gajardo fernández-gajardo",
      "doi": "10.1007/s40263-013-0138-y",
      "doi_url": "https://doi.org/10.1007/s40263-013-0138-y",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/24532027/",
      "url": "https://h2medicine.org/studies/study-fernandezgajardo-2014-therapeutic-strategies-traumatic-brain/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "neurology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "25378931",
      "year": 2014,
      "title": "Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function.",
      "title_en": null,
      "title_de": "Der Konsum von Wasser mit mehr als 3,5 mg gelöstem Wasserstoff könnte die vaskuläre Endothelfunktion verbessern.",
      "journal": "Vascular health and risk management",
      "authors": "Sakai et al.",
      "author_search": "sakai sakai",
      "doi": "10.2147/vhrm.s68844",
      "doi_url": "https://doi.org/10.2147/vhrm.s68844",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25378931/",
      "url": "https://h2medicine.org/studies/study-sakai-2014-consumption-containing-over-dissolved/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "cardiovascular",
        "oxidative-stress"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "25295663",
      "year": 2014,
      "title": "Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries.",
      "title_en": null,
      "title_de": "Wirksamkeit von oralem und topischem Wasserstoff bei sportbedingten Weichteilverletzungen.",
      "journal": "Postgraduate medicine",
      "authors": "Ostojic et al.",
      "author_search": "ostojic ostojic",
      "doi": "10.3810/pgm.2014.09.2813",
      "doi_url": "https://doi.org/10.3810/pgm.2014.09.2813",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25295663/",
      "url": "https://h2medicine.org/studies/study-ostojic-2014-oral-topical-sports-related/",
      "methods": [
        "tablets",
        "bath-topical",
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "joints-rheumatology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "25201463",
      "year": 2014,
      "title": "Effects of intravenous infusion of hydrogen-rich fluid combined with intra-cisternal infusion of magnesium sulfate in severe aneurysmal subarachnoid hemorrhage: study protocol for a randomized controlled trial.",
      "title_en": null,
      "title_de": "Wirkungen der intravenösen Infusion von wasserstoffreicher Flüssigkeit kombiniert mit intrazisternaler Infusion von Magnesiumsulfat bei schwerer aneurysmatischer Subarachnoidalblutung: Studienprotokoll für eine randomisierte kontrollierte Studie.",
      "journal": "BMC neurology",
      "authors": "Takeuchi et al.",
      "author_search": "takeuchi takeuchi",
      "doi": "10.1186/s12883-014-0176-1",
      "doi_url": "https://doi.org/10.1186/s12883-014-0176-1",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25201463/",
      "url": "https://h2medicine.org/studies/study-takeuchi-2014-intravenous-infusion-fluid-combined/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "neurology",
        "cardiovascular",
        "fundamentals-safety"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "24929023",
      "year": 2014,
      "title": "Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study.",
      "title_en": null,
      "title_de": "Therapeutische Wirksamkeit von in Kochsalzlösung infundiertem molekularem Wasserstoff bei rheumatoider Arthritis: eine randomisierte, doppelblinde, placebokontrollierte Pilotstudie.",
      "journal": "International immunopharmacology",
      "authors": "Ishibashi et al.",
      "author_search": "ishibashi ishibashi",
      "doi": "10.1016/j.intimp.2014.06.001",
      "doi_url": "https://doi.org/10.1016/j.intimp.2014.06.001",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/24929023/",
      "url": "https://h2medicine.org/studies/study-ishibashi-2014-therapeutic-infused-saline-rheumatoid/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "cancer",
        "joints-rheumatology",
        "immune-system",
        "oxidative-stress",
        "fundamentals-safety"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "25942929",
      "year": 2014,
      "title": "Polymer encapsulation of magnesium to control biodegradability and biocompatibility.",
      "title_en": null,
      "title_de": "Polymerverkapselung von Magnesium zur Steuerung von Biologisch-Abbaubarkeit und Biokompatibilität.",
      "journal": "Journal of nanoscience and nanotechnology",
      "authors": "Bazaka et al.",
      "author_search": "bazaka bazaka",
      "doi": "10.1166/jnn.2014.9409",
      "doi_url": "https://doi.org/10.1166/jnn.2014.9409",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25942929/",
      "url": "https://h2medicine.org/studies/study-bazaka-2014-polymer-encapsulation-magnesium-control/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "24890090",
      "year": 2014,
      "title": "Thiazolidine-2,4-diones derivatives as PPAR-γ agonists: synthesis, molecular docking, in vitro and in vivo antidiabetic activity with hepatotoxicity risk evaluation and effect on PPAR-γ gene expression.",
      "title_en": null,
      "title_de": "Thiazolidin-2,4-dion-Derivate als PPAR-γ-Agonisten: Synthese, molekulares Docking, antidiabetische Aktivität in vitro und in vivo mit Bewertung des Hepatotoxizitätsrisikos.",
      "journal": "Bioorganic & medicinal chemistry letters",
      "authors": "Nazreen et al.",
      "author_search": "nazreen nazreen",
      "doi": "10.1016/j.bmcl.2014.05.034",
      "doi_url": "https://doi.org/10.1016/j.bmcl.2014.05.034",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/24890090/",
      "url": "https://h2medicine.org/studies/study-nazreen-2014-thiazolidine-diones-derivatives-ppar/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "diabetes",
        "liver"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "24793096",
      "year": 2014,
      "title": "Effect of hydrogen-rich water on acute peritonitis of rat models.",
      "title_en": null,
      "title_de": "Wirkung von wasserstoffreichem Wasser auf akute Peritonitis in Rattenmodellen.",
      "journal": "International immunopharmacology",
      "authors": "Zhang et al.",
      "author_search": "zhang zhang",
      "doi": "10.1016/j.intimp.2014.04.011",
      "doi_url": "https://doi.org/10.1016/j.intimp.2014.04.011",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/24793096/",
      "url": "https://h2medicine.org/studies/study-zhang-2014-acute-peritonitis-rat-models/",
      "methods": [
        "saline-iv",
        "drinking-hrw"
      ],
      "indications": [
        "cancer",
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "24694477",
      "year": 2014,
      "title": "Do alpha-glucosidase inhibitors have the potential to induce portal venous gas? -Two clinical case reports.",
      "title_en": null,
      "title_de": "Können Alpha-Glucosidase-Hemmer portalvenöses Gas induzieren? – Zwei klinische Fallberichte.",
      "journal": "Internal medicine (Tokyo, Japan)",
      "authors": "Makiyama et al.",
      "author_search": "makiyama makiyama",
      "doi": "10.2169/internalmedicine.53.1789",
      "doi_url": "https://doi.org/10.2169/internalmedicine.53.1789",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/24694477/",
      "url": "https://h2medicine.org/studies/study-makiyama-2014-alpha-glucosidase-inhibitors-have/",
      "methods": [],
      "indications": [
        "diabetes"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "byproduct"
    },
    {
      "pmid": "24529916",
      "year": 2014,
      "title": "Parkinson's disease may be due to failure of melanin in the Substantia Nigra to produce molecular hydrogen from dissociation of water, to protect the brain from oxidative stress.",
      "title_en": null,
      "title_de": "Die Parkinson-Krankheit könnte auf das Versagen von Melanin in der Substantia nigra zurückzuführen sein, molekularen Wasserstoff aus der Dissoziation von Wasser zu produzieren.",
      "journal": "Medical hypotheses",
      "authors": "Brenner",
      "author_search": "brenner brenner",
      "doi": "10.1016/j.mehy.2014.01.013",
      "doi_url": "https://doi.org/10.1016/j.mehy.2014.01.013",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/24529916/",
      "url": "https://h2medicine.org/studies/study-brenner-2014-parkinson-disease-may-due/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "neurology",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "24509162",
      "year": 2014,
      "title": "Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion.",
      "title_en": null,
      "title_de": "Mütterliche Verabreichung von molekularem Wasserstoff lindert den durch intrauterine Ischämie-Reperfusion verursachten Schaden am fetalen Hippocampus der Ratte.",
      "journal": "Free radical biology & medicine",
      "authors": "Mano et al.",
      "author_search": "mano mano",
      "doi": "10.1016/j.freeradbiomed.2014.01.037",
      "doi_url": "https://doi.org/10.1016/j.freeradbiomed.2014.01.037",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/24509162/",
      "url": "https://h2medicine.org/studies/study-mano-2014-maternal-administration-ameliorates-rat/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "liver",
        "neurology",
        "cardiovascular",
        "womens-health",
        "pregnancy",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "24491676",
      "year": 2014,
      "title": "Clusianone, a naturally occurring nemorosone regioisomer, uncouples rat liver mitochondria and induces HepG2 cell death.",
      "title_en": null,
      "title_de": "Clusianon, ein natürlich vorkommendes Nemoroson-Regioisomer, entkoppelt Rattenleber-Mitochondrien und induziert den Zelltod von HepG2-Zellen.",
      "journal": "Chemico-biological interactions",
      "authors": "Reis et al.",
      "author_search": "reis reis",
      "doi": "10.1016/j.cbi.2014.01.015",
      "doi_url": "https://doi.org/10.1016/j.cbi.2014.01.015",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/24491676/",
      "url": "https://h2medicine.org/studies/study-reis-2014-clusianone-naturally-occurring-nemorosone/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver",
        "cancer"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "24392771",
      "year": 2014,
      "title": "Hydrogen-rich water affected blood alkalinity in physically active men.",
      "title_en": null,
      "title_de": "Wasserstoffreiches Wasser beeinflusste die Blutalkalität bei körperlich aktiven Männern.",
      "journal": "Research in sports medicine (Print)",
      "authors": "Ostojic et al.",
      "author_search": "ostojic ostojic",
      "doi": "10.1080/15438627.2013.852092",
      "doi_url": "https://doi.org/10.1080/15438627.2013.852092",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/24392771/",
      "url": "https://h2medicine.org/studies/study-ostojic-2014-affected-blood-alkalinity-physically/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "cardiovascular"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "24291328",
      "year": 2014,
      "title": "Controlling initial biodegradation of magnesium by a biocompatible strontium phosphate conversion coating.",
      "title_en": null,
      "title_de": "Steuerung der initialen Biodegradation von Magnesium durch eine biokompatible Strontiumphosphat-Konversionsbeschichtung",
      "journal": "Acta biomaterialia",
      "authors": "Chen et al.",
      "author_search": "chen chen",
      "doi": "10.1016/j.actbio.2013.11.016",
      "doi_url": "https://doi.org/10.1016/j.actbio.2013.11.016",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/24291328/",
      "url": "https://h2medicine.org/studies/study-chen-2014-controlling-initial-biodegradation-magnesium/",
      "methods": [
        "inhalation",
        "bath-topical"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "24068473",
      "year": 2014,
      "title": "DNA-binding studies and antitumor evaluation of novel water soluble organic pip and hpip analogs.",
      "title_en": null,
      "title_de": "DNA-Bindungsstudien und Antitumor-Bewertung neuartiger wasserlöslicher organischer pip- und hpip-Analoga",
      "journal": "Applied biochemistry and biotechnology",
      "authors": "Coban et al.",
      "author_search": "coban coban",
      "doi": "10.1007/s12010-013-0513-7",
      "doi_url": "https://doi.org/10.1007/s12010-013-0513-7",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/24068473/",
      "url": "https://h2medicine.org/studies/study-coban-2014-dna-binding-antitumor-soluble/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "24697097",
      "year": 2013,
      "title": "[Equol: a metabolite of soy isoflavones by intestinal microflora--a review].",
      "title_en": null,
      "title_de": "Equol: ein Metabolit von Soja-Isoflavonen durch die Darmflora — eine Übersichtsarbeit",
      "journal": "Wei sheng wu xue bao = Acta microbiologica Sinica",
      "authors": "Zheng et al.",
      "author_search": "zheng zheng",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/24697097/",
      "url": "https://h2medicine.org/studies/study-zheng-2013-equol-metabolite-soy-isoflavones/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "fundamentals-safety"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "24358804",
      "year": 2013,
      "title": "[Introspection of oxidant/antioxidant imbalance in the inner ear].",
      "title_en": null,
      "title_de": "Betrachtung des Oxidantien-/Antioxidantien-Ungleichgewichts im Innenohr",
      "journal": "Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/24358804/",
      "url": "https://h2medicine.org/studies/study-wang-2013-introspection-oxidant-antioxidant-imbalance/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "skin-aging",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "24155664",
      "year": 2013,
      "title": "Hydrogen as a new class of radioprotective agent.",
      "title_en": null,
      "title_de": "Wasserstoff als eine neue Klasse von Radioprotektoren",
      "journal": "International journal of biological sciences",
      "authors": "Qian et al.",
      "author_search": "qian qian",
      "doi": "10.7150/ijbs.7220",
      "doi_url": "https://doi.org/10.7150/ijbs.7220",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/24155664/",
      "url": "https://h2medicine.org/studies/study-qian-2013-class-radioprotective-agent/",
      "methods": [
        "saline-iv",
        "drinking-hrw"
      ],
      "indications": [
        "cancer",
        "skin-aging",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "24132155",
      "year": 2013,
      "title": "Multiple hits, including oxidative stress, as pathogenesis and treatment target in non-alcoholic steatohepatitis (NASH).",
      "title_en": null,
      "title_de": "Multiple Schädigungen, einschließlich oxidativem Stress, als Pathogenese und Behandlungsziel bei der nichtalkoholischen Steatohepatitis (NASH)",
      "journal": "International journal of molecular sciences",
      "authors": "Takaki et al.",
      "author_search": "takaki takaki",
      "doi": "10.3390/ijms141020704",
      "doi_url": "https://doi.org/10.3390/ijms141020704",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/24132155/",
      "url": "https://h2medicine.org/studies/study-takaki-2013-multiple-hits-including-oxidative/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "diabetes",
        "liver",
        "cardiovascular",
        "cancer",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "23921897",
      "year": 2013,
      "title": "Why does brain metabolism not favor burning of fatty acids to provide energy? Reflections on disadvantages of the use of free fatty acids as fuel for brain.",
      "title_en": null,
      "title_de": "Warum bevorzugt der Gehirnstoffwechsel nicht die Verbrennung von Fettsäuren zur Energiegewinnung? Überlegungen zu den Nachteilen der Verwendung freier Fettsäuren als Brennstoff für das Gehirn",
      "journal": "Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism",
      "authors": "Schönfeld et al.",
      "author_search": "schönfeld schönfeld",
      "doi": "10.1038/jcbfm.2013.128",
      "doi_url": "https://doi.org/10.1038/jcbfm.2013.128",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/23921897/",
      "url": "https://h2medicine.org/studies/study-schoenfeld-2013-why-does-brain-metabolism/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "metabolic",
        "neurology",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "23859555",
      "year": 2013,
      "title": "Molecular hydrogen: new antioxidant and anti-inflammatory therapy for rheumatoid arthritis and related diseases.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff: neue antioxidative und antiinflammatorische Therapie für rheumatoide Arthritis und verwandte Erkrankungen",
      "journal": "Current pharmaceutical design",
      "authors": "Ishibashi",
      "author_search": "ishibashi ishibashi",
      "doi": "10.2174/13816128113199990507",
      "doi_url": "https://doi.org/10.2174/13816128113199990507",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/23859555/",
      "url": "https://h2medicine.org/studies/study-ishibashi-2013-antioxidant-anti-inflammatory-rheumatoid/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cardiovascular",
        "joints-rheumatology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "23436141",
      "year": 2013,
      "title": "Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway.",
      "title_en": null,
      "title_de": "Rolle des Toll-Like-Rezeptor-(TLR-)Radikalzyklus bei chronischer Entzündung: mögliche Behandlungen mit Zielrichtung auf den TLR4-Signalweg",
      "journal": "Molecular neurobiology",
      "authors": "Lucas et al.",
      "author_search": "lucas lucas",
      "doi": "10.1007/s12035-013-8425-7",
      "doi_url": "https://doi.org/10.1007/s12035-013-8425-7",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/23436141/",
      "url": "https://h2medicine.org/studies/study-lucas-2013-toll-like-receptor-tlr/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "diabetes",
        "metabolic",
        "sports-exercise",
        "neurology",
        "cardiovascular",
        "cancer",
        "respiratory",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "24127924",
      "year": 2013,
      "title": "Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B.",
      "title_en": null,
      "title_de": "Wirkung von wasserstoffreichem Wasser auf oxidativen Stress, Leberfunktion und Viruslast bei Patienten mit chronischer Hepatitis B.",
      "journal": "Clinical and translational science",
      "authors": "Xia et al.",
      "author_search": "xia xia",
      "doi": "10.1111/cts.12076",
      "doi_url": "https://doi.org/10.1111/cts.12076",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/24127924/",
      "url": "https://h2medicine.org/studies/study-xia-2013-oxidative-stress-liver-function/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "liver",
        "oxidative-stress"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "23400965",
      "year": 2013,
      "title": "Pilot study of H₂ therapy in Parkinson's disease: a randomized double-blind placebo-controlled trial.",
      "title_en": null,
      "title_de": "Pilotstudie zur H₂-Therapie bei der Parkinson-Krankheit: eine randomisierte, doppelblinde, placebokontrollierte Studie.",
      "journal": "Movement disorders : official journal of the Movement Disorder Society",
      "authors": "Yoritaka et al.",
      "author_search": "yoritaka yoritaka",
      "doi": "10.1002/mds.25375",
      "doi_url": "https://doi.org/10.1002/mds.25375",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/23400965/",
      "url": "https://h2medicine.org/studies/study-yoritaka-2013-parkinson-disease/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "neurology",
        "oxidative-stress"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "23374763",
      "year": 2013,
      "title": "Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful bladder syndrome.",
      "title_en": null,
      "title_de": "Wirkung der Supplementierung mit wasserstoffreichem Wasser bei Patienten mit interstitieller Zystitis/Blasenschmerzsyndrom.",
      "journal": "Urology",
      "authors": "Matsumoto et al.",
      "author_search": "matsumoto matsumoto",
      "doi": "10.1016/j.urology.2012.10.026",
      "doi_url": "https://doi.org/10.1016/j.urology.2012.10.026",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/23374763/",
      "url": "https://h2medicine.org/studies/study-matsumoto-2013-supplementation-interstitial-cystitis-painful/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "24423914",
      "year": 2013,
      "title": "[Regulative effects of hydrogen-rich medium on monocytic adhesion and vascular endothelial permeability].",
      "title_en": null,
      "title_de": "Regulierende Wirkungen von wasserstoffreichem Medium auf die monozytäre Adhäsion und die vaskuläre Endothelpermeabilität",
      "journal": "Zhonghua yi xue za zhi",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/24423914/",
      "url": "https://h2medicine.org/studies/study-wang-2013-regulative-medium-monocytic-adhesion/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cardiovascular"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "24001618",
      "year": 2013,
      "title": "A non-aqueous reduction process for purifying ¹⁵³Gd produced in natural europium targets.",
      "title_en": null,
      "title_de": "Ein nichtwässriges Reduktionsverfahren zur Aufreinigung von ¹⁵³Gd, das in natürlichen Europium-Targets erzeugt wird",
      "journal": "Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine",
      "authors": "Johnsen et al.",
      "author_search": "johnsen johnsen",
      "doi": "10.1016/j.apradiso.2013.07.025",
      "doi_url": "https://doi.org/10.1016/j.apradiso.2013.07.025",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/24001618/",
      "url": "https://h2medicine.org/studies/study-johnsen-2013-non-aqueous-reduction-process/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "skin-aging"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "23967088",
      "year": 2013,
      "title": "An in silico analysis of troponin I mutations in hypertrophic cardiomyopathy of Indian origin.",
      "title_en": null,
      "title_de": "Eine In-silico-Analyse von Troponin-I-Mutationen bei hypertropher Kardiomyopathie indischer Herkunft",
      "journal": "PloS one",
      "authors": "Ramachandran et al.",
      "author_search": "ramachandran ramachandran",
      "doi": "10.1371/journal.pone.0070704",
      "doi_url": "https://doi.org/10.1371/journal.pone.0070704",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/23967088/",
      "url": "https://h2medicine.org/studies/study-ramachandran-2013-silico-analysis-troponin-mutations/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cardiovascular"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "23871246",
      "year": 2013,
      "title": "Hydrogen-rich saline ameliorates renal injury induced by unilateral ureteral obstruction in rats.",
      "title_en": null,
      "title_de": "Wasserstoffreiche Kochsalzlösung lindert die durch einseitige Ureterobstruktion induzierte Nierenschädigung bei Ratten.",
      "journal": "International immunopharmacology",
      "authors": "Xu et al.",
      "author_search": "xu xu",
      "doi": "10.1016/j.intimp.2013.06.033",
      "doi_url": "https://doi.org/10.1016/j.intimp.2013.06.033",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/23871246/",
      "url": "https://h2medicine.org/studies/study-xu-2013-saline-ameliorates-renal-injury/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "kidney-dialysis",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "23852510",
      "year": 2013,
      "title": "Molecular hydrogen consumption in the human body during the inhalation of hydrogen gas.",
      "title_en": null,
      "title_de": "Verbrauch von molekularem Wasserstoff im menschlichen Körper während der Inhalation von Wasserstoffgas.",
      "journal": "Advances in experimental medicine and biology",
      "authors": "Shimouchi et al.",
      "author_search": "shimouchi shimouchi",
      "doi": "10.1007/978-1-4614-7411-1_42",
      "doi_url": "https://doi.org/10.1007/978-1-4614-7411-1_42",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/23852510/",
      "url": "https://h2medicine.org/studies/study-shimouchi-2013-consumption-body-during-inhalation/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "23786587",
      "year": 2013,
      "title": "Molecular hydrogen protects human lymphocyte AHH-1 cells against 12C6+ heavy ion radiation.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff schützt menschliche AHH-1-Lymphozytenzellen vor ¹²C⁶⁺-Schwerionenstrahlung.",
      "journal": "International journal of radiation biology",
      "authors": "Yang et al.",
      "author_search": "yang yang",
      "doi": "10.3109/09553002.2013.817704",
      "doi_url": "https://doi.org/10.3109/09553002.2013.817704",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/23786587/",
      "url": "https://h2medicine.org/studies/study-yang-2013-protects-lymphocyte-ahh-cells/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "23610159",
      "year": 2013,
      "title": "Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome.",
      "title_en": null,
      "title_de": "Wasserstoffreiches Wasser senkt die Serum-LDL-Cholesterinspiegel und verbessert die HDL-Funktion bei Patienten mit potenziellem metabolischem Syndrom.",
      "journal": "Journal of lipid research",
      "authors": "Song et al.",
      "author_search": "song song",
      "doi": "10.1194/jlr.m036640",
      "doi_url": "https://doi.org/10.1194/jlr.m036640",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/23610159/",
      "url": "https://h2medicine.org/studies/study-song-2013-decreases-serum-ldl-cholesterol/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "metabolic",
        "cardiovascular",
        "cancer",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "23467041",
      "year": 2013,
      "title": "A surface-eroding poly(1,3-trimethylene carbonate) coating for fully biodegradable magnesium-based stent applications: toward better biofunction, biodegradation and biocompatibility.",
      "title_en": null,
      "title_de": "Oberflächenerodierende PTMC-Beschichtung für vollständig biologisch abbaubare magnesiumbasierte Stent-Anwendungen.",
      "journal": "Acta biomaterialia",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1016/j.actbio.2013.02.041",
      "doi_url": "https://doi.org/10.1016/j.actbio.2013.02.041",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/23467041/",
      "url": "https://h2medicine.org/studies/study-wang-2013-surface-eroding-poly-trimethylene/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "sports-exercise",
        "cardiovascular",
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "23457571",
      "year": 2013,
      "title": "Amide proton solvent protection in amylin fibrils probed by quenched hydrogen exchange NMR.",
      "title_en": null,
      "title_de": "Lösungsmittelschutz von Amidprotonen in Amylin-Fibrillen, untersucht mittels gequenchter Wasserstoffaustausch-NMR.",
      "journal": "PloS one",
      "authors": "Alexandrescu",
      "author_search": "alexandrescu alexandrescu",
      "doi": "10.1371/journal.pone.0056467",
      "doi_url": "https://doi.org/10.1371/journal.pone.0056467",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/23457571/",
      "url": "https://h2medicine.org/studies/study-alexandrescu-2013-amide-proton-solvent-protection/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "diabetes"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "22537465",
      "year": 2012,
      "title": "Molecular hydrogen and radiation protection",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff und Strahlenschutz",
      "journal": "Free Radical Research",
      "authors": "Chuai et al.",
      "author_search": "chuai chuai",
      "doi": "10.3109/10715762.2012.689429",
      "doi_url": "https://doi.org/10.3109/10715762.2012.689429",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/22537465/",
      "url": "https://h2medicine.org/studies/study-chuai-2012-radiation-protection/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "cancer",
        "oxidative-stress",
        "liver",
        "fundamentals"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "22965001",
      "year": 2012,
      "title": "Proton reduction to hydrogen in biological and chemical systems.",
      "title_en": null,
      "title_de": "Protonenreduktion zu Wasserstoff in biologischen und chemischen Systemen.",
      "journal": "Physical chemistry chemical physics : PCCP",
      "authors": "Tran et al.",
      "author_search": "tran tran",
      "doi": "10.1039/c2cp42413d",
      "doi_url": "https://doi.org/10.1039/c2cp42413d",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/22965001/",
      "url": "https://h2medicine.org/studies/study-tran-2012-proton-reduction-biological-chemical/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "22720117",
      "year": 2012,
      "title": "Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff als aufkommendes therapeutisches medizinisches Gas für neurodegenerative und andere Erkrankungen.",
      "journal": "Oxidative medicine and cellular longevity",
      "authors": "Ohno et al.",
      "author_search": "ohno ohno",
      "doi": "10.1155/2012/353152",
      "doi_url": "https://doi.org/10.1155/2012/353152",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/22720117/",
      "url": "https://h2medicine.org/studies/study-ohno-2012-emerging-therapeutic-medical-neurodegenerative/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "diabetes",
        "metabolic",
        "liver",
        "neurology",
        "cardiovascular",
        "cancer",
        "respiratory",
        "kidney-dialysis",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "22585131",
      "year": 2012,
      "title": "Contributions of the microbial hydrogen economy to colonic homeostasis.",
      "title_en": null,
      "title_de": "Beiträge des mikrobiellen Wasserstoffhaushalts zur kolischen Homöostase.",
      "journal": "Nature reviews. Gastroenterology & hepatology",
      "authors": "Carbonero et al.",
      "author_search": "carbonero carbonero",
      "doi": "10.1038/nrgastro.2012.85",
      "doi_url": "https://doi.org/10.1038/nrgastro.2012.85",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/22585131/",
      "url": "https://h2medicine.org/studies/study-carbonero-2012-contributions-microbial-economy-colonic/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cancer",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "21621588",
      "year": 2012,
      "title": "Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases.",
      "title_en": null,
      "title_de": "Molekularer Wasserstoff ist ein neuartiges Antioxidans zur effizienten Reduktion von oxidativem Stress mit Potenzial für die Verbesserung mitochondrialer Erkrankungen.",
      "journal": "Biochimica et biophysica acta",
      "authors": "Ohta",
      "author_search": "ohta ohta",
      "doi": "10.1016/j.bbagen.2011.05.006",
      "doi_url": "https://doi.org/10.1016/j.bbagen.2011.05.006",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/21621588/",
      "url": "https://h2medicine.org/studies/study-ohta-2012-antioxidant-efficiently-reduce-oxidative/",
      "methods": [
        "inhalation",
        "saline-iv",
        "bath-topical",
        "drinking-hrw"
      ],
      "indications": [
        "cancer",
        "skin-aging",
        "eye",
        "immune-system",
        "allergy",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "23079742",
      "year": 2012,
      "title": "Binding hot-spots in an antibody-ssDNA interface: a molecular dynamics study.",
      "title_en": null,
      "title_de": "Bindungs-Hotspots in einer Antikörper-ssDNA-Grenzfläche: eine molekulardynamische Studie.",
      "journal": "Molecular bioSystems",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1039/c2mb25250c",
      "doi_url": "https://doi.org/10.1039/c2mb25250c",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/23079742/",
      "url": "https://h2medicine.org/studies/study-wang-2012-binding-hot-spots-antibody/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "23014490",
      "year": 2012,
      "title": "A hydrogen gas-water equilibration method produces accurate and precise stable hydrogen isotope ratio measurements in nutrition studies.",
      "title_en": null,
      "title_de": "Eine Wasserstoffgas-Wasser-Äquilibrierungsmethode liefert genaue und präzise Messungen stabiler Wasserstoff-Isotopenverhältnisse in Ernährungsstudien.",
      "journal": "The Journal of nutrition",
      "authors": "Wong et al.",
      "author_search": "wong wong",
      "doi": "10.3945/jn.112.167957",
      "doi_url": "https://doi.org/10.3945/jn.112.167957",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/23014490/",
      "url": "https://h2medicine.org/studies/study-wong-2012-equilibration-method-produces-accurate/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "metabolic",
        "neurology"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "22797884",
      "year": 2012,
      "title": "Evidence for the preservation of native inter- and intra-molecular hydrogen bonds in the desolvated FK-binding protein·FK506 complex produced by electrospray ionization.",
      "title_en": null,
      "title_de": "Nachweis der Erhaltung nativer inter- und intramolekularer Wasserstoffbrückenbindungen im desolvatisierten FK-Bindungsprotein·FK506-Komplex, erzeugt durch Elektrospray-Ionisation.",
      "journal": "Journal of the American Society for Mass Spectrometry",
      "authors": "Hopper et al.",
      "author_search": "hopper hopper",
      "doi": "10.1007/s13361-012-0430-y",
      "doi_url": "https://doi.org/10.1007/s13361-012-0430-y",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/22797884/",
      "url": "https://h2medicine.org/studies/study-hopper-2012-evidence-preservation-native-inter/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "22687834",
      "year": 2012,
      "title": "Hydrogen may inhibit collagen-induced platelet aggregation: an ex vivo and in vivo study.",
      "title_en": null,
      "title_de": "Wasserstoff könnte die kollageninduzierte Thrombozytenaggregation hemmen: eine Ex-vivo- und In-vivo-Studie.",
      "journal": "Internal medicine (Tokyo, Japan)",
      "authors": "Takeuchi et al.",
      "author_search": "takeuchi takeuchi",
      "doi": "10.2169/internalmedicine.51.7161",
      "doi_url": "https://doi.org/10.2169/internalmedicine.51.7161",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/22687834/",
      "url": "https://h2medicine.org/studies/study-takeuchi-2012-may-inhibit-collagen-induced/",
      "methods": [
        "inhalation",
        "saline-iv"
      ],
      "indications": [
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "22648259",
      "year": 2012,
      "title": "Hydrogen therapy may be an effective and specific novel treatment for aplastic anemia.",
      "title_en": null,
      "title_de": "Die Wasserstofftherapie könnte eine wirksame und spezifische neuartige Behandlung für aplastische Anämie sein.",
      "journal": "Medical science monitor : international medical journal of experimental and clinical research",
      "authors": "Qian et al.",
      "author_search": "qian qian",
      "doi": "10.12659/msm.882886",
      "doi_url": "https://doi.org/10.12659/msm.882886",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/22648259/",
      "url": "https://h2medicine.org/studies/study-qian-2012-may-effective-specific-aplastic/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "22560529",
      "year": 2012,
      "title": "Serum alkalinization and hydrogen-rich water in healthy men.",
      "title_en": null,
      "title_de": "Serumalkalisierung und wasserstoffreiches Wasser bei gesunden Männern.",
      "journal": "Mayo Clinic proceedings",
      "authors": "Ostojic",
      "author_search": "ostojic ostojic",
      "doi": "10.1016/j.mayocp.2012.02.008",
      "doi_url": "https://doi.org/10.1016/j.mayocp.2012.02.008",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/22560529/",
      "url": "https://h2medicine.org/studies/study-ostojic-2012-serum-alkalinization-healthy-men/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "22460088",
      "year": 2012,
      "title": "Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis.",
      "title_en": null,
      "title_de": "Wasserstoffreiche Kochsalzlösung schützt Immunzellen vor strahlungsinduzierter Apoptose.",
      "journal": "Medical science monitor : international medical journal of experimental and clinical research",
      "authors": "Yang et al.",
      "author_search": "yang yang",
      "doi": "10.12659/msm.882616",
      "doi_url": "https://doi.org/10.12659/msm.882616",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/22460088/",
      "url": "https://h2medicine.org/studies/study-yang-2012-saline-protects-immunocytes-radiation/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "cancer",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "22431222",
      "year": 2012,
      "title": "Charge-site-dependent dissociation of hydrogen-rich radical peptide cations upon vacuum UV photoexcitation.",
      "title_en": null,
      "title_de": "Ladungsstellenabhängige Dissoziation wasserstoffreicher Radikal-Peptidkationen bei Vakuum-UV-Photoanregung.",
      "journal": "Chemistry (Weinheim an der Bergstrasse, Germany)",
      "authors": "Madsen et al.",
      "author_search": "madsen madsen",
      "doi": "10.1002/chem.201103534",
      "doi_url": "https://doi.org/10.1002/chem.201103534",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/22431222/",
      "url": "https://h2medicine.org/studies/study-madsen-2012-charge-site-dependent-dissociation/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "skin-aging"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "22425564",
      "year": 2012,
      "title": "Inhibition of hepatitis C virus NS5A by fluoro-olefin based γ-turn mimetics.",
      "title_en": null,
      "title_de": "Hemmung des NS5A-Proteins des Hepatitis-C-Virus durch Fluor-Olefin-basierte γ-Turn-Mimetika.",
      "journal": "Bioorganic & medicinal chemistry letters",
      "authors": "Chang et al.",
      "author_search": "chang chang",
      "doi": "10.1016/j.bmcl.2012.02.051",
      "doi_url": "https://doi.org/10.1016/j.bmcl.2012.02.051",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/22425564/",
      "url": "https://h2medicine.org/studies/study-chang-2012-inhibition-hepatitis-virus-ns5a/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "22390199",
      "year": 2012,
      "title": "Hydrogenase: the next antibiotic target?",
      "title_en": null,
      "title_de": "Hydrogenase: das nächste Antibiotika-Ziel?",
      "journal": "Clinical science (London, England : 1979)",
      "authors": "Nie et al.",
      "author_search": "nie nie",
      "doi": "10.1042/cs20110396",
      "doi_url": "https://doi.org/10.1042/cs20110396",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/22390199/",
      "url": "https://h2medicine.org/studies/study-nie-2012-hydrogenase-next-antibiotic-target/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "22339382",
      "year": 2012,
      "title": "Evaluation of outgassing, tear strength, and detail reproduction in alginate substitute materials.",
      "title_en": null,
      "title_de": "Bewertung von Ausgasung, Reißfestigkeit und Detailwiedergabe in Alginat-Ersatzmaterialien.",
      "journal": "Operative dentistry",
      "authors": "Baxter et al.",
      "author_search": "baxter baxter",
      "doi": "10.2341/11-365-l",
      "doi_url": "https://doi.org/10.2341/11-365-l",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/22339382/",
      "url": "https://h2medicine.org/studies/study-baxter-2012-outgassing-tear-strength-detail/",
      "methods": [
        "inhalation",
        "bath-topical"
      ],
      "indications": [
        "oral-health"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "22287575",
      "year": 2012,
      "title": "Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats.",
      "title_en": null,
      "title_de": "Die orale Aufnahme von wasserstoffreichem Wasser hemmt die Intimahyperplasie in arterialisierten Venentransplantaten bei Ratten.",
      "journal": "Cardiovascular research",
      "authors": "Sun et al.",
      "author_search": "sun sun",
      "doi": "10.1093/cvr/cvs024",
      "doi_url": "https://doi.org/10.1093/cvr/cvs024",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/22287575/",
      "url": "https://h2medicine.org/studies/study-sun-2012-oral-intake-inhibits-intimal/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "cardiovascular",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "22259109",
      "year": 2012,
      "title": "Estimation of molecular hydrogen consumption in the human whole body after the ingestion of hydrogen-rich water.",
      "title_en": null,
      "title_de": "Schätzung des Verbrauchs von molekularem Wasserstoff im gesamten menschlichen Körper nach der Aufnahme von wasserstoffreichem Wasser",
      "journal": "Advances in experimental medicine and biology",
      "authors": "Shimouchi et al.",
      "author_search": "shimouchi shimouchi",
      "doi": "10.1007/978-1-4614-1566-4_36",
      "doi_url": "https://doi.org/10.1007/978-1-4614-1566-4_36",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/22259109/",
      "url": "https://h2medicine.org/studies/study-shimouchi-2012-estimation-consumption-whole-body/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "22070900",
      "year": 2012,
      "title": "Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes.",
      "title_en": null,
      "title_de": "Wasserstoffreiches elektrolysiertes warmes Wasser unterdrückt die Faltenbildung gegen UVA-Strahlen zusammen mit der Typ-I-Kollagenproduktion und der Verringerung von oxidativem Stress in Fibroblasten sowie der Verhinderung von Zellschäden in Keratinozyten.",
      "journal": "Journal of photochemistry and photobiology. B, Biology",
      "authors": "Kato et al.",
      "author_search": "kato kato",
      "doi": "10.1016/j.jphotobiol.2011.09.006",
      "doi_url": "https://doi.org/10.1016/j.jphotobiol.2011.09.006",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/22070900/",
      "url": "https://h2medicine.org/studies/study-kato-2012-electrolyzed-warm-represses-wrinkle/",
      "methods": [
        "bath-topical"
      ],
      "indications": [
        "cancer",
        "skin-aging",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "21736547",
      "year": 2011,
      "title": "Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications.",
      "title_en": null,
      "title_de": "Jüngste Fortschritte in Richtung Wasserstoffmedizin: Potenzial von molekularem Wasserstoff für präventive und therapeutische Anwendungen.",
      "journal": "Current pharmaceutical design",
      "authors": "Ohta",
      "author_search": "ohta ohta",
      "doi": "10.2174/138161211797052664",
      "doi_url": "https://doi.org/10.2174/138161211797052664",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/21736547/",
      "url": "https://h2medicine.org/studies/study-ohta-2011-recent-progress-toward-medicine/",
      "methods": [
        "inhalation",
        "saline-iv",
        "bath-topical",
        "drinking-hrw"
      ],
      "indications": [
        "cancer",
        "skin-aging",
        "eye",
        "immune-system",
        "allergy",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "21736540",
      "year": 2011,
      "title": "The principle and the potential approach to ROS-dependent cytotoxicity by non-pharmaceutical therapies: optimal use of medical gases with antioxidant properties.",
      "title_en": null,
      "title_de": "Das Prinzip und der mögliche Ansatz zur ROS-abhängigen Zytotoxizität durch nichtpharmazeutische Therapien: optimale Nutzung medizinischer Gase mit antioxidativen Eigenschaften.",
      "journal": "Current pharmaceutical design",
      "authors": "Noda et al.",
      "author_search": "noda noda",
      "doi": "10.2174/138161211797052600",
      "doi_url": "https://doi.org/10.2174/138161211797052600",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/21736540/",
      "url": "https://h2medicine.org/studies/study-noda-2011-principle-approach-ros-dependent/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "diabetes",
        "neurology",
        "cancer",
        "eye",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "21573992",
      "year": 2011,
      "title": "Defective protein folding and aggregation as the basis of neurodegenerative diseases: the darker aspect of proteins.",
      "title_en": null,
      "title_de": "Fehlerhafte Proteinfaltung und Aggregation als Grundlage neurodegenerativer Erkrankungen: der dunklere Aspekt von Proteinen.",
      "journal": "Cell biochemistry and biophysics",
      "authors": "Naeem et al.",
      "author_search": "naeem naeem",
      "doi": "10.1007/s12013-011-9200-x",
      "doi_url": "https://doi.org/10.1007/s12013-011-9200-x",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/21573992/",
      "url": "https://h2medicine.org/studies/study-naeem-2011-defective-protein-folding-aggregation/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "neurology",
        "cancer"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "21562446",
      "year": 2011,
      "title": "Feasibility of measuring human pancreatic perfusion in vivo using imaging techniques.",
      "title_en": null,
      "title_de": "Machbarkeit der Messung der menschlichen Pankreasperfusion in vivo mittels bildgebender Verfahren",
      "journal": "Pancreas",
      "authors": "Tsushima et al.",
      "author_search": "tsushima tsushima",
      "doi": "10.1097/mpa.0b013e318215ac22",
      "doi_url": "https://doi.org/10.1097/mpa.0b013e318215ac22",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/21562446/",
      "url": "https://h2medicine.org/studies/study-tsushima-2011-feasibility-measuring-pancreatic-perfusion/",
      "methods": [],
      "indications": [
        "skin-aging"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "21251046",
      "year": 2011,
      "title": "Hydrogen resuscitation, a new cytoprotective approach.",
      "title_en": null,
      "title_de": "Wasserstoff-Reanimation, ein neuer zytoprotektiver Ansatz.",
      "journal": "Clinical and experimental pharmacology & physiology",
      "authors": "Zheng et al.",
      "author_search": "zheng zheng",
      "doi": "10.1111/j.1440-1681.2011.05479.x",
      "doi_url": "https://doi.org/10.1111/j.1440-1681.2011.05479.x",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/21251046/",
      "url": "https://h2medicine.org/studies/study-zheng-2011-resuscitation-cytoprotective-approach/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "liver",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "21244359",
      "year": 2011,
      "title": "Melatonin-mitochondria interplay in health and disease.",
      "title_en": null,
      "title_de": "Melatonin-Mitochondrien-Wechselspiel in Gesundheit und Krankheit",
      "journal": "Current topics in medicinal chemistry",
      "authors": "Acuña Castroviejo et al.",
      "author_search": "acuña castroviejo acuña castroviejo",
      "doi": "10.2174/156802611794863517",
      "doi_url": "https://doi.org/10.2174/156802611794863517",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/21244359/",
      "url": "https://h2medicine.org/studies/study-acunacastroviejo-2011-melatonin-mitochondria-interplay-health/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "neurology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "22417501",
      "year": 2011,
      "title": "Digestibility, fermentability, and energy value of highly cross-linked phosphate tapioca starch in men.",
      "title_en": null,
      "title_de": "Verdaulichkeit, Fermentierbarkeit und Energiewert von hochgradig quervernetzter Phosphat-Tapiokastärke bei Männern",
      "journal": "Journal of food science",
      "authors": "Tachibe et al.",
      "author_search": "tachibe tachibe",
      "doi": "10.1111/j.1750-3841.2011.02247.x",
      "doi_url": "https://doi.org/10.1111/j.1750-3841.2011.02247.x",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/22417501/",
      "url": "https://h2medicine.org/studies/study-tachibe-2011-digestibility-fermentability-energy-value/",
      "methods": [],
      "indications": [
        "diabetes"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "22079833",
      "year": 2011,
      "title": "The Trichomonas vaginalis hydrogenosome proteome is highly reduced relative to mitochondria, yet complex compared with mitosomes.",
      "title_en": null,
      "title_de": "Das Hydrogenosom-Proteom von Trichomonas vaginalis ist im Vergleich zu Mitochondrien stark reduziert, jedoch komplex im Vergleich zu Mitosomen",
      "journal": "International journal for parasitology",
      "authors": "Schneider et al.",
      "author_search": "schneider schneider",
      "doi": "10.1016/j.ijpara.2011.10.001",
      "doi_url": "https://doi.org/10.1016/j.ijpara.2011.10.001",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/22079833/",
      "url": "https://h2medicine.org/studies/study-schneider-2011-trichomonas-vaginalis-hydrogenosome-proteome/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "21859325",
      "year": 2011,
      "title": "Variation in lunar neutron dose estimates.",
      "title_en": null,
      "title_de": "Variation in den Schätzungen der lunaren Neutronendosis",
      "journal": "Radiation research",
      "authors": "Slaba et al.",
      "author_search": "slaba slaba",
      "doi": "10.1667/rr2616.1",
      "doi_url": "https://doi.org/10.1667/rr2616.1",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/21859325/",
      "url": "https://h2medicine.org/studies/study-slaba-2011-variation-lunar-neutron-dose/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "21764987",
      "year": 2011,
      "title": "Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress.",
      "title_en": null,
      "title_de": "Die Wasserstofftherapie mildert strahlungsinduzierte Lungenschäden durch Reduktion von oxidativem Stress",
      "journal": "American journal of physiology. Lung cellular and molecular physiology",
      "authors": "Terasaki et al.",
      "author_search": "terasaki terasaki",
      "doi": "10.1152/ajplung.00008.2011",
      "doi_url": "https://doi.org/10.1152/ajplung.00008.2011",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/21764987/",
      "url": "https://h2medicine.org/studies/study-terasaki-2011-attenuates-irradiation-induced-lung/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cancer",
        "respiratory",
        "skin-aging",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "21656033",
      "year": 2011,
      "title": "Fabrication and characterization of bioactive composite coatings on Mg-Zn-Ca alloy by MAO/sol-gel.",
      "title_en": null,
      "title_de": "Herstellung und Charakterisierung bioaktiver Verbundbeschichtungen auf einer Mg-Zn-Ca-Legierung durch MAO/Sol-Gel",
      "journal": "Journal of materials science. Materials in medicine",
      "authors": "Gao et al.",
      "author_search": "gao gao",
      "doi": "10.1007/s10856-011-4349-9",
      "doi_url": "https://doi.org/10.1007/s10856-011-4349-9",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/21656033/",
      "url": "https://h2medicine.org/studies/study-gao-2011-fabrication-characterization-bioactive-composite/",
      "methods": [
        "inhalation",
        "bath-topical"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "21596020",
      "year": 2011,
      "title": "Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage.",
      "title_en": null,
      "title_de": "Wasserstoffreiches Medium schützt menschliche Hautfibroblasten vor durch hohe Glukose oder Mannitol induzierten oxidativen Schäden",
      "journal": "Biochemical and biophysical research communications",
      "authors": "Yu et al.",
      "author_search": "yu yu",
      "doi": "10.1016/j.bbrc.2011.05.024",
      "doi_url": "https://doi.org/10.1016/j.bbrc.2011.05.024",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/21596020/",
      "url": "https://h2medicine.org/studies/study-yu-2011-medium-protects-skin-fibroblasts/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "diabetes",
        "skin-aging",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "21455114",
      "year": 2011,
      "title": "A possible prevention strategy of radiation pneumonitis: combine radiotherapy with aerosol inhalation of hydrogen-rich solution.",
      "title_en": null,
      "title_de": "Eine mögliche Präventionsstrategie für Strahlenpneumonitis: Kombination von Strahlentherapie mit Aerosol-Inhalation einer wasserstoffreichen Lösung",
      "journal": "Medical science monitor : international medical journal of experimental and clinical research",
      "authors": "Chuai et al.",
      "author_search": "chuai chuai",
      "doi": "10.12659/msm.881698",
      "doi_url": "https://doi.org/10.12659/msm.881698",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/21455114/",
      "url": "https://h2medicine.org/studies/study-chuai-2011-possible-prevention-strategy-radiation/",
      "methods": [
        "inhalation",
        "saline-iv"
      ],
      "indications": [
        "cancer"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "21335650",
      "year": 2011,
      "title": "Production of clinically useful positron emitter beams during carbon ion deceleration.",
      "title_en": null,
      "title_de": "Erzeugung klinisch nutzbarer Positronenstrahler-Strahlen während der Abbremsung von Kohlenstoffionen",
      "journal": "Physics in medicine and biology",
      "authors": "Lazzeroni et al.",
      "author_search": "lazzeroni lazzeroni",
      "doi": "10.1088/0031-9155/56/6/005",
      "doi_url": "https://doi.org/10.1088/0031-9155/56/6/005",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/21335650/",
      "url": "https://h2medicine.org/studies/study-lazzeroni-2011-production-clinically-useful-positron/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver",
        "cancer",
        "skin-aging"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "21269826",
      "year": 2011,
      "title": "Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors.",
      "title_en": null,
      "title_de": "Chinazoline mit intramolekularem Wasserstoffbrücken-Gerüst (iMHBS) als duale PI3K/mTOR-Inhibitoren",
      "journal": "Bioorganic & medicinal chemistry letters",
      "authors": "Liu et al.",
      "author_search": "liu liu",
      "doi": "10.1016/j.bmcl.2010.12.026",
      "doi_url": "https://doi.org/10.1016/j.bmcl.2010.12.026",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/21269826/",
      "url": "https://h2medicine.org/studies/study-liu-2011-quinazolines-intra-bonding-scaffold/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "21215337",
      "year": 2011,
      "title": "Perfusion electrodeposition of calcium phosphate on additive manufactured titanium scaffolds for bone engineering.",
      "title_en": null,
      "title_de": "Perfusions-Elektrodeposition von Calciumphosphat auf additiv gefertigten Titangerüsten für das Knochen-Engineering",
      "journal": "Acta biomaterialia",
      "authors": "Chai et al.",
      "author_search": "chai chai",
      "doi": "10.1016/j.actbio.2010.12.032",
      "doi_url": "https://doi.org/10.1016/j.actbio.2010.12.032",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/21215337/",
      "url": "https://h2medicine.org/studies/study-chai-2011-perfusion-electrodeposition-calcium-phosphate/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "20851533",
      "year": 2011,
      "title": "Hydrogen therapy may reduce the risks related to radiation-induced oxidative stress in space flight.",
      "title_en": null,
      "title_de": "Die Wasserstofftherapie könnte die mit strahlungsinduziertem oxidativem Stress verbundenen Risiken bei der Raumfahrt reduzieren",
      "journal": "Medical hypotheses",
      "authors": "Schoenfeld et al.",
      "author_search": "schoenfeld schoenfeld",
      "doi": "10.1016/j.mehy.2010.08.046",
      "doi_url": "https://doi.org/10.1016/j.mehy.2010.08.046",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/20851533/",
      "url": "https://h2medicine.org/studies/study-schoenfeld-2011-may-reduce-risks-related/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "metabolic",
        "cancer",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "21166060",
      "year": 2010,
      "title": "[Research advances on hydrogen therapy in nervous system diseases].",
      "title_en": null,
      "title_de": "Forschungsfortschritte zur Wasserstofftherapie bei Erkrankungen des Nervensystems",
      "journal": "Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences",
      "authors": "Hong et al.",
      "author_search": "hong hong",
      "doi": "10.3785/j.issn.1008-9292.2010.06.015",
      "doi_url": "https://doi.org/10.3785/j.issn.1008-9292.2010.06.015",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/21166060/",
      "url": "https://h2medicine.org/studies/study-hong-2010-research-advances-nervous-system/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "neurology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "20708922",
      "year": 2010,
      "title": "Computational glycoscience: characterizing the spatial and temporal properties of glycans and glycan-protein complexes.",
      "title_en": null,
      "title_de": "Computergestützte Glykowissenschaft: Charakterisierung der räumlichen und zeitlichen Eigenschaften von Glykanen und Glykan-Protein-Komplexen.",
      "journal": "Current opinion in structural biology",
      "authors": "Woods et al.",
      "author_search": "woods woods",
      "doi": "10.1016/j.sbi.2010.07.005",
      "doi_url": "https://doi.org/10.1016/j.sbi.2010.07.005",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/20708922/",
      "url": "https://h2medicine.org/studies/study-woods-2010-computational-glycoscience-characterizing-spatial/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "20423296",
      "year": 2010,
      "title": "Amyloid formation in surfactants and alcohols: membrane mimetics or structural switchers?",
      "title_en": null,
      "title_de": "Amyloidbildung in Tensiden und Alkoholen: Membranmimetika oder strukturelle Umschalter?",
      "journal": "Current protein & peptide science",
      "authors": "Otzen",
      "author_search": "otzen otzen",
      "doi": "10.2174/138920310791330622",
      "doi_url": "https://doi.org/10.2174/138920310791330622",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/20423296/",
      "url": "https://h2medicine.org/studies/study-otzen-2010-amyloid-formation-surfactants-alcohols/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "20347528",
      "year": 2010,
      "title": "Hydrogen as a novel and effective treatment of acute carbon monoxide poisoning.",
      "title_en": null,
      "title_de": "Wasserstoff als neuartige und wirksame Behandlung der akuten Kohlenmonoxidvergiftung.",
      "journal": "Medical hypotheses",
      "authors": "Shen et al.",
      "author_search": "shen shen",
      "doi": "10.1016/j.mehy.2010.02.029",
      "doi_url": "https://doi.org/10.1016/j.mehy.2010.02.029",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/20347528/",
      "url": "https://h2medicine.org/studies/study-shen-2010-effective-acute-carbon-monoxide/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "neurology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "20216947",
      "year": 2010,
      "title": "Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome - an open label pilot study",
      "title_en": null,
      "title_de": "Wirksamkeit von wasserstoffreichem Wasser auf den Antioxidans-Status von Personen mit potenziellem metabolischem Syndrom — eine offene Pilotstudie",
      "journal": "Journal of Clinical Biochemistry and Nutrition",
      "authors": "Nakao et al.",
      "author_search": "nakao nakao",
      "doi": "10.3164/jcbn.09-100",
      "doi_url": "https://doi.org/10.3164/jcbn.09-100",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/20216947/",
      "url": "https://h2medicine.org/studies/study-nakao-2010-hydrogen-rich-water-metabolic-syndrome-antioxidant/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "metabolic",
        "cardiovascular",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "21275114",
      "year": 2010,
      "title": "The hypothesis of an effective safe and novel radioprotective agent: hydrogen-rich solution.",
      "title_en": null,
      "title_de": "Die Hypothese eines wirksamen, sicheren und neuartigen Radioprotektors: wasserstoffreiche Lösung.",
      "journal": "The West Indian medical journal",
      "authors": "Qian et al.",
      "author_search": "qian qian",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/21275114/",
      "url": "https://h2medicine.org/studies/study-qian-2010-hypothesis-effective-safe-radioprotective/",
      "methods": [
        "saline-iv"
      ],
      "indications": [
        "neurology",
        "cancer",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "21042740",
      "year": 2010,
      "title": "Antitumor effects of nano-bubble hydrogen-dissolved water are enhanced by coexistent platinum colloid and the combined hyperthermia with apoptosis-like cell death.",
      "title_en": null,
      "title_de": "Antitumorwirkungen von Wasser mit gelöstem Nanobläschen-Wasserstoff werden durch koexistierendes Platin-Kolloid und die kombinierte Hyperthermie mit apoptoseähnlichem Zelltod verstärkt.",
      "journal": "Oncology reports",
      "authors": "Asada et al.",
      "author_search": "asada asada",
      "doi": "10.3892/or_00001006",
      "doi_url": "https://doi.org/10.3892/or_00001006",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/21042740/",
      "url": "https://h2medicine.org/studies/study-asada-2010-antitumor-nano-bubble-dissolved/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "cancer",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "20858206",
      "year": 2010,
      "title": "Spontaneous adjustment mechanism in an RNA-binding protein: cooperation between energetic stabilization and target search enhancement.",
      "title_en": null,
      "title_de": "Spontaner Anpassungsmechanismus in einem RNA-bindenden Protein: Zusammenwirken von energetischer Stabilisierung und Verbesserung der Zielsuche.",
      "journal": "Protein and peptide letters",
      "authors": "Kurisaki et al.",
      "author_search": "kurisaki kurisaki",
      "doi": "10.2174/0929866511009011547",
      "doi_url": "https://doi.org/10.2174/0929866511009011547",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/20858206/",
      "url": "https://h2medicine.org/studies/study-kurisaki-2010-spontaneous-adjustment-mechanism-rna/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "neurology",
        "cancer"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "20801581",
      "year": 2010,
      "title": "Oral administration of mannitol may be an effective treatment for ischemia-reperfusion injury.",
      "title_en": null,
      "title_de": "Die orale Verabreichung von Mannitol könnte eine wirksame Behandlung des Ischämie-Reperfusions-Schadens sein.",
      "journal": "Medical hypotheses",
      "authors": "Liu et al.",
      "author_search": "liu liu",
      "doi": "10.1016/j.mehy.2010.07.048",
      "doi_url": "https://doi.org/10.1016/j.mehy.2010.07.048",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/20801581/",
      "url": "https://h2medicine.org/studies/study-liu-2010-oral-administration-mannitol-may/",
      "methods": [
        "inhalation",
        "saline-iv",
        "drinking-hrw"
      ],
      "indications": [
        "liver",
        "neurology",
        "cardiovascular",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "20570654",
      "year": 2010,
      "title": "Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving differentiation and paracrine potentials.",
      "title_en": null,
      "title_de": "Die Behandlung mit Wasserstoffgas verlängert die replikative Lebensspanne multipotenter Knochenmark-Stromazellen in vitro unter Erhaltung des Differenzierungs- und parakrinen Potenzials.",
      "journal": "Biochemical and biophysical research communications",
      "authors": "Kawasaki et al.",
      "author_search": "kawasaki kawasaki",
      "doi": "10.1016/j.bbrc.2010.06.009",
      "doi_url": "https://doi.org/10.1016/j.bbrc.2010.06.009",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/20570654/",
      "url": "https://h2medicine.org/studies/study-kawasaki-2010-prolongs-replicative-lifespan-bone/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "20388631",
      "year": 2010,
      "title": "A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical trial.",
      "title_en": null,
      "title_de": "Ein neuartiges bioaktives Hämodialysesystem unter Verwendung von gelöstem Diwasserstoff (H₂), erzeugt durch Wasserelektrolyse: eine klinische Studie",
      "journal": "Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association",
      "authors": "Nakayama et al.",
      "author_search": "nakayama nakayama",
      "doi": "10.1093/ndt/gfq196",
      "doi_url": "https://doi.org/10.1093/ndt/gfq196",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/20388631/",
      "url": "https://h2medicine.org/studies/study-nakayama-2010-bioactive-haemodialysis-system-dissolved/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cardiovascular",
        "cancer",
        "kidney-dialysis",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "20298796",
      "year": 2010,
      "title": "Microbial equol production attenuates colonic methanogenesis and sulphidogenesis in vitro.",
      "title_en": null,
      "title_de": "Mikrobielle Equol-Produktion mildert kolische Methanogenese und Sulfidogenese in vitro.",
      "journal": "Anaerobe",
      "authors": "Bolca et al.",
      "author_search": "bolca bolca",
      "doi": "10.1016/j.anaerobe.2010.03.002",
      "doi_url": "https://doi.org/10.1016/j.anaerobe.2010.03.002",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/20298796/",
      "url": "https://h2medicine.org/studies/study-bolca-2010-microbial-equol-production-attenuates/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "20031201",
      "year": 2010,
      "title": "A biodegradable polymer-based coating to control the performance of magnesium alloy orthopaedic implants.",
      "title_en": null,
      "title_de": "Eine biologisch abbaubare polymerbasierte Beschichtung zur Steuerung der Leistung von orthopädischen Implantaten aus Magnesiumlegierung.",
      "journal": "Biomaterials",
      "authors": "Wong et al.",
      "author_search": "wong wong",
      "doi": "10.1016/j.biomaterials.2009.11.111",
      "doi_url": "https://doi.org/10.1016/j.biomaterials.2009.11.111",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/20031201/",
      "url": "https://h2medicine.org/studies/study-wong-2010-biodegradable-polymer-coating-control/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "sports-exercise",
        "joints-rheumatology",
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "19765780",
      "year": 2010,
      "title": "Failure of d-psicose absorbed in the small intestine to metabolize into energy and its low large intestinal fermentability in humans.",
      "title_en": null,
      "title_de": "Versagen von im Dünndarm absorbierter D-Psicose, in Energie verstoffwechselt zu werden, und ihre geringe Fermentierbarkeit im Dickdarm beim Menschen",
      "journal": "Metabolism: clinical and experimental",
      "authors": "Iida et al.",
      "author_search": "iida iida",
      "doi": "10.1016/j.metabol.2009.07.018",
      "doi_url": "https://doi.org/10.1016/j.metabol.2009.07.018",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/19765780/",
      "url": "https://h2medicine.org/studies/study-iida-2010-failure-psicose-absorbed-small/",
      "methods": [],
      "indications": [
        "metabolic"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "19725814",
      "year": 2010,
      "title": "Use of laser speckle flowgraphy in ocular blood flow research.",
      "title_en": null,
      "title_de": "Verwendung der Laser-Speckle-Flowgraphie in der Forschung zum okulären Blutfluss.",
      "journal": "Acta ophthalmologica",
      "authors": "Sugiyama et al.",
      "author_search": "sugiyama sugiyama",
      "doi": "10.1111/j.1755-3768.2009.01586.x",
      "doi_url": "https://doi.org/10.1111/j.1755-3768.2009.01586.x",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/19725814/",
      "url": "https://h2medicine.org/studies/study-sugiyama-2010-use-laser-speckle-flowgraphy/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "eye"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "19664884",
      "year": 2010,
      "title": "Hydrogen therapy may be an effective and specific novel treatment for acute radiation syndrome.",
      "title_en": null,
      "title_de": "Die Wasserstofftherapie könnte eine wirksame und spezifische neuartige Behandlung für das akute Strahlensyndrom sein.",
      "journal": "Medical hypotheses",
      "authors": "Liu et al.",
      "author_search": "liu liu",
      "doi": "10.1016/j.mehy.2009.07.017",
      "doi_url": "https://doi.org/10.1016/j.mehy.2009.07.017",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/19664884/",
      "url": "https://h2medicine.org/studies/study-liu-2010-may-effective-specific-acute/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "neurology",
        "cancer",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "19505462",
      "year": 2009,
      "title": "Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?",
      "title_en": null,
      "title_de": "Stehen die Wirkungen von Alpha-Glucosidase-Hemmern auf kardiovaskuläre Ereignisse im Zusammenhang mit erhöhten Wasserstoffgasspiegeln im Magen-Darm-Trakt?",
      "journal": "FEBS letters",
      "authors": "Suzuki et al.",
      "author_search": "suzuki suzuki",
      "doi": "10.1016/j.febslet.2009.05.052",
      "doi_url": "https://doi.org/10.1016/j.febslet.2009.05.052",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/19505462/",
      "url": "https://h2medicine.org/studies/study-suzuki-2009-alpha-glucosidase-inhibitors-cardiovascular/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "cardiovascular",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "19486890",
      "year": 2009,
      "title": "Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate.",
      "title_en": null,
      "title_de": "Wasserstoff vermittelt die Unterdrückung der durch Dextran-Natriumsulfat induzierten Kolonentzündung.",
      "journal": "Biochemical and biophysical research communications",
      "authors": "Kajiya et al.",
      "author_search": "kajiya kajiya",
      "doi": "10.1016/j.bbrc.2009.05.117",
      "doi_url": "https://doi.org/10.1016/j.bbrc.2009.05.117",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/19486890/",
      "url": "https://h2medicine.org/studies/study-kajiya-2009-mediates-suppression-colon-inflammation/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "metabolic",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "19377306",
      "year": 2009,
      "title": "A novel antibody fragment targeting HAb18G/CD147 with cytotoxicity and decreased immunogenicity.",
      "title_en": null,
      "title_de": "Ein neuartiges Antikörperfragment, das auf HAb18G/CD147 abzielt, mit Zytotoxizität und verringerter Immunogenität.",
      "journal": "Cancer biology & therapy",
      "authors": "Zhu et al.",
      "author_search": "zhu zhu",
      "doi": "10.4161/cbt.8.11.8531",
      "doi_url": "https://doi.org/10.4161/cbt.8.11.8531",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/19377306/",
      "url": "https://h2medicine.org/studies/study-zhu-2009-antibody-fragment-targeting-hab18g/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver",
        "cancer"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "19237201",
      "year": 2009,
      "title": "Organotin meclofenamic complexes: Synthesis, crystal structures and antiproliferative activity of the first complexes of meclofenamic acid - novel anti-tuberculosis agents.",
      "title_en": null,
      "title_de": "Organozinn-Meclofenaminsäure-Komplexe: Synthese, Kristallstrukturen und antiproliferative Aktivität der ersten Komplexe der Meclofenaminsäure – neuartige Antituberkulose-Wirkstoffe.",
      "journal": "Journal of inorganic biochemistry",
      "authors": "Kovala-Demertzi et al.",
      "author_search": "kovala-demertzi kovala-demertzi",
      "doi": "10.1016/j.jinorgbio.2009.01.014",
      "doi_url": "https://doi.org/10.1016/j.jinorgbio.2009.01.014",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/19237201/",
      "url": "https://h2medicine.org/studies/study-kovalademertzi-2009-organotin-meclofenamic-complexes-synthesis/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "respiratory"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "19202298",
      "year": 2009,
      "title": "Enhanced induction of mitochondrial damage and apoptosis in human leukemia HL-60 cells due to electrolyzed-reduced water and glutathione.",
      "title_en": null,
      "title_de": "Verstärkte Induktion mitochondrialer Schäden und Apoptose in menschlichen Leukämie-HL-60-Zellen durch elektrolysiert-reduziertes Wasser und Glutathion.",
      "journal": "Bioscience, biotechnology, and biochemistry",
      "authors": "Tsai et al.",
      "author_search": "tsai tsai",
      "doi": "10.1271/bbb.80413",
      "doi_url": "https://doi.org/10.1271/bbb.80413",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/19202298/",
      "url": "https://h2medicine.org/studies/study-tsai-2009-enhanced-induction-mitochondrial-damage/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "19109480",
      "year": 2009,
      "title": "Oral abscess caused by Campylobacter rectus: case report and literature review.",
      "title_en": null,
      "title_de": "Oraler Abszess verursacht durch Campylobacter rectus: Fallbericht und Literaturübersicht.",
      "journal": "Journal of clinical microbiology",
      "authors": "Mahlen et al.",
      "author_search": "mahlen mahlen",
      "doi": "10.1128/jcm.01590-08",
      "doi_url": "https://doi.org/10.1128/jcm.01590-08",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/19109480/",
      "url": "https://h2medicine.org/studies/study-mahlen-2009-oral-abscess-caused-campylobacter/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "cancer",
        "oral-health"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "18508354",
      "year": 2009,
      "title": "The mechanism of deposition of calcium phosphate coatings from solution onto magnesium alloy AZ31.",
      "title_en": null,
      "title_de": "Der Mechanismus der Abscheidung von Calciumphosphat-Beschichtungen aus Lösung auf der Magnesiumlegierung AZ31.",
      "journal": "Journal of biomedical materials research. Part A",
      "authors": "Gray-Munro et al.",
      "author_search": "gray-munro gray-munro",
      "doi": "10.1002/jbm.a.32107",
      "doi_url": "https://doi.org/10.1002/jbm.a.32107",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/18508354/",
      "url": "https://h2medicine.org/studies/study-graymunro-2009-mechanism-deposition-calcium-phosphate/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "19083400",
      "year": 2008,
      "title": "Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance",
      "title_en": null,
      "title_de": "Supplementierung mit wasserstoffreichem Wasser verbessert den Fett- und Glukosestoffwechsel bei Patienten mit Typ-2-Diabetes oder gestörter Glukosetoleranz",
      "journal": "Nutrition Research",
      "authors": "Kajiyama et al.",
      "author_search": "kajiyama kajiyama",
      "doi": "10.1016/j.nutres.2008.01.008",
      "doi_url": "https://doi.org/10.1016/j.nutres.2008.01.008",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/19083400/",
      "url": "https://h2medicine.org/studies/study-kajiyama-2008-hydrogen-rich-water-type-2-diabetes-glucose-metabolism/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "diabetes",
        "metabolic",
        "cardiovascular"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "19102360",
      "year": 2008,
      "title": "Extensive atrophic gastritis linked to increased levels of intraluminal hydrogen gas.",
      "title_en": null,
      "title_de": "Ausgedehnte atrophische Gastritis in Verbindung mit erhöhten Spiegeln von intraluminalem Wasserstoffgas",
      "journal": "Hepato-gastroenterology",
      "authors": "Urita et al.",
      "author_search": "urita urita",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/19102360/",
      "url": "https://h2medicine.org/studies/study-urita-2008-extensive-atrophic-gastritis-linked/",
      "methods": [],
      "indications": [
        "other"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "18473836",
      "year": 2008,
      "title": "The hydrogenosome as a drug target.",
      "title_en": null,
      "title_de": "Das Hydrogenosom als Wirkstoffziel.",
      "journal": "Current pharmaceutical design",
      "authors": "Benchimol",
      "author_search": "benchimol benchimol",
      "doi": "10.2174/138161208784041114",
      "doi_url": "https://doi.org/10.2174/138161208784041114",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/18473836/",
      "url": "https://h2medicine.org/studies/study-benchimol-2008-hydrogenosome-drug-target/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cardiovascular",
        "respiratory",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "18270200",
      "year": 2008,
      "title": "A role for IOP1 in mammalian cytosolic iron-sulfur protein biogenesis.",
      "title_en": null,
      "title_de": "Eine Rolle von IOP1 in der Biogenese zytosolischer Eisen-Schwefel-Proteine bei Säugetieren.",
      "journal": "The Journal of biological chemistry",
      "authors": "Song et al.",
      "author_search": "song song",
      "doi": "10.1074/jbc.m708077200",
      "doi_url": "https://doi.org/10.1074/jbc.m708077200",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/18270200/",
      "url": "https://h2medicine.org/studies/study-song-2008-iop1-mammalian-cytosolic-iron/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "sports-exercise",
        "neurology"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "18175936",
      "year": 2008,
      "title": "Inhibitory effect of electrolyzed reduced water on tumor angiogenesis.",
      "title_en": null,
      "title_de": "Hemmende Wirkung von elektrolysiert-reduziertem Wasser auf die Tumorangiogenese.",
      "journal": "Biological & pharmaceutical bulletin",
      "authors": "Ye et al.",
      "author_search": "ye ye",
      "doi": "10.1248/bpb.31.19",
      "doi_url": "https://doi.org/10.1248/bpb.31.19",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/18175936/",
      "url": "https://h2medicine.org/studies/study-ye-2008-inhibitory-electrolyzed-reduced-tumor/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "cardiovascular",
        "cancer",
        "respiratory",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "18066702",
      "year": 2008,
      "title": "Hydrogen as an energy source for the human pathogen Bilophila wadsworthia.",
      "title_en": null,
      "title_de": "Wasserstoff als Energiequelle für den humanpathogenen Erreger Bilophila wadsworthia.",
      "journal": "Antonie van Leeuwenhoek",
      "authors": "da Silva et al.",
      "author_search": "da silva da silva",
      "doi": "10.1007/s10482-007-9215-x",
      "doi_url": "https://doi.org/10.1007/s10482-007-9215-x",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/18066702/",
      "url": "https://h2medicine.org/studies/study-dasilva-2008-energy-source-pathogen-bilophila/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "17853416",
      "year": 2008,
      "title": "Preliminary tribological evaluation of nanostructured diamond coatings against ultra-high molecular weight polyethylene.",
      "title_en": null,
      "title_de": "Vorläufige tribologische Bewertung nanostrukturierter Diamantbeschichtungen gegen ultrahochmolekulares Polyethylen.",
      "journal": "Journal of biomedical materials research. Part B, Applied biomaterials",
      "authors": "Hill et al.",
      "author_search": "hill hill",
      "doi": "10.1002/jbm.b.30926",
      "doi_url": "https://doi.org/10.1002/jbm.b.30926",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/17853416/",
      "url": "https://h2medicine.org/studies/study-hill-2008-preliminary-tribological-nanostructured-diamond/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "joints-rheumatology"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "17683943",
      "year": 2008,
      "title": "Practical experiences with the synthesis of [11C]CH3I through gas phase iodination reaction using a TRACERlabFXC synthesis module.",
      "title_en": null,
      "title_de": "Praktische Erfahrungen mit der Synthese von [¹¹C]CH₃I durch eine Gasphasen-Iodierungsreaktion unter Verwendung eines TRACERlabFXC-Synthesemoduls",
      "journal": "Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine",
      "authors": "Kniess et al.",
      "author_search": "kniess kniess",
      "doi": "10.1016/j.apradiso.2007.06.005",
      "doi_url": "https://doi.org/10.1016/j.apradiso.2007.06.005",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/17683943/",
      "url": "https://h2medicine.org/studies/study-kniess-2008-practical-experiences-synthesis-11c/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "17951687",
      "year": 2007,
      "title": "A mitosome purification protocol based on percoll density gradients and its use in validating the mitosomal nature of Entamoeba histolytica mitochondrial Hsp70.",
      "title_en": null,
      "title_de": "Ein Mitosom-Aufreinigungsprotokoll auf Basis von Percoll-Dichtegradienten und seine Verwendung zur Validierung der mitosomalen Natur des mitochondrialen Hsp70 von Entamoeba histolytica",
      "journal": "Methods in molecular biology (Clifton, N.J.)",
      "authors": "Tovar et al.",
      "author_search": "tovar tovar",
      "doi": "10.1007/978-1-59745-466-7_11",
      "doi_url": "https://doi.org/10.1007/978-1-59745-466-7_11",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/17951687/",
      "url": "https://h2medicine.org/studies/study-tovar-2007-mitosome-purification-protocol-percoll/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "17926473",
      "year": 2007,
      "title": "[Blood flow and morphofunctional status of gastroduodenal mucosa in different phases of peptic ulcer].",
      "title_en": null,
      "title_de": "Blutfluss und morphofunktioneller Status der gastroduodenalen Schleimhaut in verschiedenen Phasen des peptischen Ulkus",
      "journal": "Terapevticheskii arkhiv",
      "authors": "Maev et al.",
      "author_search": "maev maev",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/17926473/",
      "url": "https://h2medicine.org/studies/study-maev-2007-blood-flow-morphofunctional-status/",
      "methods": [],
      "indications": [
        "immune-system"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "17486089",
      "year": 2007,
      "title": "Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals",
      "title_en": null,
      "title_de": "Wasserstoff wirkt als therapeutisches Antioxidans, indem er selektiv zytotoxische Sauerstoffradikale reduziert",
      "journal": "Nature Medicine",
      "authors": "Ohsawa et al.",
      "author_search": "ohsawa ohsawa",
      "doi": "10.1038/nm1577",
      "doi_url": "https://doi.org/10.1038/nm1577",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/17486089/",
      "url": "https://h2medicine.org/studies/study-ohsawa-2007-therapeutic-antioxidant-cytotoxic-oxygen-radicals/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "fundamentals",
        "mechanism",
        "neurology",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "17159237",
      "year": 2006,
      "title": "Electrolyzed-reduced water protects against oxidative damage to DNA, RNA, and protein.",
      "title_en": null,
      "title_de": "Elektrolysiert-reduziertes Wasser schützt vor oxidativen Schäden an DNA, RNA und Protein",
      "journal": "Applied biochemistry and biotechnology",
      "authors": "Lee et al.",
      "author_search": "lee lee",
      "doi": "10.1385/abab:135:2:133",
      "doi_url": "https://doi.org/10.1385/abab:135:2:133",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/17159237/",
      "url": "https://h2medicine.org/studies/study-lee-2006-electrolyzed-reduced-protects-against/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "17125074",
      "year": 2006,
      "title": "[Temporary clipping and cerebral blood flow in patients with cerebral aneurysms].",
      "title_en": null,
      "title_de": "Temporäres Clipping und zerebraler Blutfluss bei Patienten mit zerebralen Aneurysmen",
      "journal": "Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko",
      "authors": "Asaturian et al.",
      "author_search": "asaturian asaturian",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/17125074/",
      "url": "https://h2medicine.org/studies/study-asaturian-2006-temporary-clipping-cerebral-blood/",
      "methods": [],
      "indications": [
        "neurology",
        "cardiovascular"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "16894148",
      "year": 2006,
      "title": "Interstellar chemistry.",
      "title_en": null,
      "title_de": "Interstellare Chemie",
      "journal": "Proceedings of the National Academy of Sciences of the United States of America",
      "authors": "Klemperer",
      "author_search": "klemperer klemperer",
      "doi": "10.1073/pnas.0605352103",
      "doi_url": "https://doi.org/10.1073/pnas.0605352103",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/16894148/",
      "url": "https://h2medicine.org/studies/study-klemperer-2006-interstellar-chemistry/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "16760903",
      "year": 2006,
      "title": "Electrolyzed-reduced water reduced hemodialysis-induced erythrocyte impairment in end-stage renal disease patients.",
      "title_en": null,
      "title_de": "Elektrolytisch reduziertes Wasser verringerte die hämodialyseinduzierte Erythrozytenschädigung bei Patienten mit terminaler Niereninsuffizienz",
      "journal": "Kidney international",
      "authors": "Huang et al.",
      "author_search": "huang huang",
      "doi": "10.1038/sj.ki.5001576",
      "doi_url": "https://doi.org/10.1038/sj.ki.5001576",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/16760903/",
      "url": "https://h2medicine.org/studies/study-huang-2006-electrolyzed-reduced-reduced-hemodialysis/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "metabolic",
        "kidney-dialysis",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "15679729",
      "year": 2005,
      "title": "Birth-related increase in intracolonic hydrogen gas and nitric oxide as indicator of host-microbial interactions.",
      "title_en": null,
      "title_de": "Geburtsbedingter Anstieg von intrakolonischem Wasserstoffgas und Stickstoffmonoxid als Indikator für Wirt-Mikroben-Interaktionen",
      "journal": "Allergy",
      "authors": "Sobko et al.",
      "author_search": "sobko sobko",
      "doi": "10.1111/j.1398-9995.2005.00737.x",
      "doi_url": "https://doi.org/10.1111/j.1398-9995.2005.00737.x",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/15679729/",
      "url": "https://h2medicine.org/studies/study-sobko-2005-birth-related-increase-intracolonic/",
      "methods": [],
      "indications": [
        "liver",
        "immune-system",
        "allergy"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "byproduct"
    },
    {
      "pmid": "15667272",
      "year": 2005,
      "title": "Use of molecular hydrogen as an energy substrate by human pathogenic bacteria.",
      "title_en": null,
      "title_de": "Nutzung von molekularem Wasserstoff als Energiesubstrat durch humanpathogene Bakterien",
      "journal": "Biochemical Society transactions",
      "authors": "Maier",
      "author_search": "maier maier",
      "doi": "10.1042/bst0330083",
      "doi_url": "https://doi.org/10.1042/bst0330083",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/15667272/",
      "url": "https://h2medicine.org/studies/study-maier-2005-use-energy-substrate-pathogenic/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver",
        "respiratory",
        "womens-health"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "15578160",
      "year": 2005,
      "title": "Isolation and characterisation of an equol-producing mixed microbial culture from a human faecal sample and its activity under gastrointestinal conditions.",
      "title_en": null,
      "title_de": "Isolierung und Charakterisierung einer equolproduzierenden gemischten mikrobiellen Kultur aus einer menschlichen Stuhlprobe und ihre Aktivität unter gastrointestinalen Bedingungen",
      "journal": "Archives of microbiology",
      "authors": "Decroos et al.",
      "author_search": "decroos decroos",
      "doi": "10.1007/s00203-004-0747-4",
      "doi_url": "https://doi.org/10.1007/s00203-004-0747-4",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/15578160/",
      "url": "https://h2medicine.org/studies/study-decroos-2005-isolation-characterisation-equol-producing/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "15085273",
      "year": 2004,
      "title": "Hydrogen storage methods.",
      "title_en": null,
      "title_de": "Methoden zur Wasserstoffspeicherung",
      "journal": "Die Naturwissenschaften",
      "authors": "Züttel",
      "author_search": "züttel züttel",
      "doi": "10.1007/s00114-004-0516-x",
      "doi_url": "https://doi.org/10.1007/s00114-004-0516-x",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/15085273/",
      "url": "https://h2medicine.org/studies/study-zuettel-2004-storage-methods/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "15762476",
      "year": 2004,
      "title": "[Studies on human breast cancer tissues with Raman microspectroscopy].",
      "title_en": null,
      "title_de": "Untersuchungen an menschlichem Brustkrebsgewebe mittels Raman-Mikrospektroskopie",
      "journal": "Guang pu xue yu guang pu fen xi = Guang pu",
      "authors": "Yu et al.",
      "author_search": "yu yu",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/15762476/",
      "url": "https://h2medicine.org/studies/study-yu-2004-breast-cancer-tissues-raman/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "metabolic",
        "cancer"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "15561487",
      "year": 2004,
      "title": "Bioavailability of cellobiose by tolerance test and breath hydrogen excretion in humans.",
      "title_en": null,
      "title_de": "Bioverfügbarkeit von Cellobiose mittels Toleranztest und Atemwasserstoffausscheidung beim Menschen",
      "journal": "Nutrition (Burbank, Los Angeles County, Calif.)",
      "authors": "Nakamura et al.",
      "author_search": "nakamura nakamura",
      "doi": "10.1016/j.nut.2004.08.005",
      "doi_url": "https://doi.org/10.1016/j.nut.2004.08.005",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/15561487/",
      "url": "https://h2medicine.org/studies/study-nakamura-2004-bioavailability-cellobiose-tolerance-test/",
      "methods": [],
      "indications": [
        "fundamentals-safety"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "14554258",
      "year": 2003,
      "title": "Availability and use of molecular hydrogen as an energy substrate for Helicobacter species.",
      "title_en": null,
      "title_de": "Verfügbarkeit und Nutzung von molekularem Wasserstoff als Energiesubstrat für Helicobacter-Arten",
      "journal": "Microbes and infection",
      "authors": "Maier",
      "author_search": "maier maier",
      "doi": "10.1016/j.micinf.2003.08.002",
      "doi_url": "https://doi.org/10.1016/j.micinf.2003.08.002",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/14554258/",
      "url": "https://h2medicine.org/studies/study-maier-2003-availability-use-energy-substrate/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver",
        "respiratory"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "14698375",
      "year": 2003,
      "title": "Detection of flatus using a portable hydrogen gas analyzer.",
      "title_en": null,
      "title_de": "Nachweis von Darmgas mit einem tragbaren Wasserstoffgas-Analysator.",
      "journal": "Journal of clinical anesthesia",
      "authors": "Terai et al.",
      "author_search": "terai terai",
      "doi": "10.1016/j.jclinane.2003.03.001",
      "doi_url": "https://doi.org/10.1016/j.jclinane.2003.03.001",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/14698375/",
      "url": "https://h2medicine.org/studies/study-terai-2003-detection-flatus-portable-analyzer/",
      "methods": [],
      "indications": [
        "other"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "12947435",
      "year": 2003,
      "title": "Comparison of digestibility and breath hydrogen gas excretion of fructo-oligosaccharide, galactosyl-sucrose, and isomalto-oligosaccharide in healthy human subjects.",
      "title_en": null,
      "title_de": "Vergleich der Verdaulichkeit und Atemwasserstoff-Ausscheidung von Fructo-Oligosacchariden, Galactosyl-Saccharose und Isomalto-Oligosacchariden bei gesunden menschlichen Probanden.",
      "journal": "European journal of clinical nutrition",
      "authors": "Oku et al.",
      "author_search": "oku oku",
      "doi": "10.1038/sj.ejcn.1601666",
      "doi_url": "https://doi.org/10.1038/sj.ejcn.1601666",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/12947435/",
      "url": "https://h2medicine.org/studies/study-oku-2003-comparison-digestibility-breath-excretion/",
      "methods": [],
      "indications": [
        "other"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "12846769",
      "year": 2003,
      "title": "Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water.",
      "title_en": null,
      "title_de": "Verringerter hämodialyseinduzierter oxidativer Stress bei Patienten mit terminaler Niereninsuffizienz durch elektrolytisch reduziertes Wasser.",
      "journal": "Kidney international",
      "authors": "Huang et al.",
      "author_search": "huang huang",
      "doi": "10.1046/j.1523-1755.2003.00118.x",
      "doi_url": "https://doi.org/10.1046/j.1523-1755.2003.00118.x",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/12846769/",
      "url": "https://h2medicine.org/studies/study-huang-2003-reduced-hemodialysis-induced-oxidative/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "metabolic",
        "sports-exercise",
        "cardiovascular",
        "kidney-dialysis",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "12121756",
      "year": 2002,
      "title": "Fe-only hydrogenases: structure, function and evolution.",
      "title_en": null,
      "title_de": "Fe-only-Hydrogenasen: Struktur, Funktion und Evolution",
      "journal": "Journal of inorganic biochemistry",
      "authors": "Nicolet et al.",
      "author_search": "nicolet nicolet",
      "doi": "10.1016/s0162-0134(02)00392-6",
      "doi_url": "https://doi.org/10.1016/s0162-0134(02)00392-6",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/12121756/",
      "url": "https://h2medicine.org/studies/study-nicolet-2002-only-hydrogenases-structure-function/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "11899097",
      "year": 2002,
      "title": "Melatonin, mitochondrial homeostasis and mitochondrial-related diseases.",
      "title_en": null,
      "title_de": "Melatonin, mitochondriale Homöostase und mitochondrienbedingte Erkrankungen",
      "journal": "Current topics in medicinal chemistry",
      "authors": "Acuña Castroviejo et al.",
      "author_search": "acuña castroviejo acuña castroviejo",
      "doi": "10.2174/1568026023394344",
      "doi_url": "https://doi.org/10.2174/1568026023394344",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/11899097/",
      "url": "https://h2medicine.org/studies/study-acunacastroviejo-2002-melatonin-mitochondrial-homeostasis-mitochondrial/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "sports-exercise",
        "neurology",
        "oxidative-stress"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "12228253",
      "year": 2002,
      "title": "Crystal structure of human sex hormone-binding globulin in complex with 2-methoxyestradiol reveals the molecular basis for high affinity interactions with C-2 derivatives of estradiol.",
      "title_en": null,
      "title_de": "Kristallstruktur des humanen sexualhormonbindenden Globulins im Komplex mit 2-Methoxyestradiol offenbart die molekulare Grundlage für hochaffine Interaktionen mit C-2-Derivaten von Estradiol",
      "journal": "The Journal of biological chemistry",
      "authors": "Avvakumov et al.",
      "author_search": "avvakumov avvakumov",
      "doi": "10.1074/jbc.m207762200",
      "doi_url": "https://doi.org/10.1074/jbc.m207762200",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/12228253/",
      "url": "https://h2medicine.org/studies/study-avvakumov-2002-crystal-structure-sex-hormone/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "12049920",
      "year": 2002,
      "title": "Hydrogenases in green algae: do they save the algae's life and solve our energy problems?",
      "title_en": null,
      "title_de": "Hydrogenasen in Grünalgen: Retten sie das Leben der Algen und lösen sie unsere Energieprobleme?",
      "journal": "Trends in plant science",
      "authors": "Happe et al.",
      "author_search": "happe happe",
      "doi": "10.1016/s1360-1385(02)02274-4",
      "doi_url": "https://doi.org/10.1016/s1360-1385(02)02274-4",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/12049920/",
      "url": "https://h2medicine.org/studies/study-happe-2002-hydrogenases-green-algae-they/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "sports-exercise",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "11847105",
      "year": 2002,
      "title": "Conserved properties of hydrogenosomal and mitochondrial ADP/ATP carriers: a common origin for both organelles.",
      "title_en": null,
      "title_de": "Konservierte Eigenschaften hydrogenosomaler und mitochondrialer ADP/ATP-Carrier: ein gemeinsamer Ursprung für beide Organellen.",
      "journal": "The EMBO journal",
      "authors": "van der Giezen et al.",
      "author_search": "van der giezen van der giezen",
      "doi": "10.1093/emboj/21.4.572",
      "doi_url": "https://doi.org/10.1093/emboj/21.4.572",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/11847105/",
      "url": "https://h2medicine.org/studies/study-vandergiezen-2002-conserved-properties-hydrogenosomal-mitochondrial/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "11797894",
      "year": 2002,
      "title": "Tritium doses from chronic atmospheric releases: a new approach proposed for regulatory compliance.",
      "title_en": null,
      "title_de": "Tritium-Dosen aus chronischen atmosphärischen Freisetzungen: ein neuer Ansatz zur Einhaltung regulatorischer Vorgaben.",
      "journal": "Health physics",
      "authors": "Peterson et al.",
      "author_search": "peterson peterson",
      "doi": "10.1097/00004032-200202000-00006",
      "doi_url": "https://doi.org/10.1097/00004032-200202000-00006",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/11797894/",
      "url": "https://h2medicine.org/studies/study-peterson-2002-tritium-doses-chronic-atmospheric/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "11713968",
      "year": 2001,
      "title": "Lactulose-induced pneumatosis intestinalis and pneumoperitoneum.",
      "title_en": null,
      "title_de": "Lactulose-induzierte Pneumatosis intestinalis und Pneumoperitoneum.",
      "journal": "Digestive diseases and sciences",
      "authors": "Goodman et al.",
      "author_search": "goodman goodman",
      "doi": "10.1023/a:1012308911096",
      "doi_url": "https://doi.org/10.1023/a:1012308911096",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/11713968/",
      "url": "https://h2medicine.org/studies/study-goodman-2001-lactulose-induced-pneumatosis-intestinalis/",
      "methods": [],
      "indications": [
        "other"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "byproduct"
    },
    {
      "pmid": "11293569",
      "year": 2001,
      "title": "Hydrogenosome morphological variation induced by fibronectin and other drugs in Trichomonas vaginalis and Tritrichomonas foetus.",
      "title_en": null,
      "title_de": "Morphologische Variation der Hydrogenosomen induziert durch Fibronektin und andere Wirkstoffe bei Trichomonas vaginalis und Tritrichomonas foetus.",
      "journal": "Parasitology research",
      "authors": "Benchimol",
      "author_search": "benchimol benchimol",
      "doi": "10.1007/s004360000329",
      "doi_url": "https://doi.org/10.1007/s004360000329",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/11293569/",
      "url": "https://h2medicine.org/studies/study-benchimol-2001-hydrogenosome-morphological-variation-induced/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "10944388",
      "year": 2000,
      "title": "Crystal structure of bovine duodenase, a serine protease, with dual trypsin and chymotrypsin-like specificities.",
      "title_en": null,
      "title_de": "Kristallstruktur der bovinen Duodenase, einer Serinprotease, mit dualer trypsin- und chymotrypsinähnlicher Spezifität.",
      "journal": "Proteins",
      "authors": "Pletnev et al.",
      "author_search": "pletnev pletnev",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/10944388/",
      "url": "https://h2medicine.org/studies/study-pletnev-2000-crystal-structure-bovine-duodenase/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "10812376",
      "year": 2000,
      "title": "Improved lactose digestion and intolerance among African-American adolescent girls fed a dairy-rich diet.",
      "title_en": null,
      "title_de": "Verbesserte Lactoseverdauung und -intoleranz bei afroamerikanischen heranwachsenden Mädchen unter milchreicher Ernährung.",
      "journal": "Journal of the American Dietetic Association",
      "authors": "Pribila et al.",
      "author_search": "pribila pribila",
      "doi": "10.1016/s0002-8223(00)00162-0",
      "doi_url": "https://doi.org/10.1016/s0002-8223(00)00162-0",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/10812376/",
      "url": "https://h2medicine.org/studies/study-pribila-2000-improved-lactose-digestion-intolerance/",
      "methods": [],
      "indications": [
        "skin-aging"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "10650267",
      "year": 2000,
      "title": "Endoscopic measurement of pancreatic tissue perfusion in patients with chronic pancreatitis and control patients.",
      "title_en": null,
      "title_de": "Endoskopische Messung der pankreatischen Gewebeperfusion bei Patienten mit chronischer Pankreatitis und Kontrollpatienten.",
      "journal": "Gastrointestinal endoscopy",
      "authors": "Lewis et al.",
      "author_search": "lewis lewis",
      "doi": "10.1016/s0016-5107(00)70417-2",
      "doi_url": "https://doi.org/10.1016/s0016-5107(00)70417-2",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/10650267/",
      "url": "https://h2medicine.org/studies/study-lewis-2000-endoscopic-measurement-pancreatic-tissue/",
      "methods": [],
      "indications": [
        "cardiovascular"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "10193122",
      "year": 1999,
      "title": "[Lactose intolerance in children. An analysis of hydrogen gas in exhaled air simplifies and improves diagnosis].",
      "title_en": null,
      "title_de": "Lactoseintoleranz bei Kindern. Eine Analyse von Wasserstoffgas in der Ausatemluft vereinfacht und verbessert die Diagnose.",
      "journal": "Lakartidningen",
      "authors": "Särnblad et al.",
      "author_search": "särnblad särnblad",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/10193122/",
      "url": "https://h2medicine.org/studies/study-saernblad-1999-lactose-intolerance-children-analysis/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "10520620",
      "year": 1999,
      "title": "Consequences of incomplete carbohydrate absorption from fruit juice consumption in infants.",
      "title_en": null,
      "title_de": "Folgen der unvollständigen Kohlenhydratabsorption beim Konsum von Fruchtsaft bei Säuglingen.",
      "journal": "Archives of pediatrics & adolescent medicine",
      "authors": "Cole et al.",
      "author_search": "cole cole",
      "doi": "10.1001/archpedi.153.10.1098",
      "doi_url": "https://doi.org/10.1001/archpedi.153.10.1098",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/10520620/",
      "url": "https://h2medicine.org/studies/study-cole-1999-consequences-incomplete-carbohydrate-absorption/",
      "methods": [],
      "indications": [
        "sports-exercise",
        "respiratory"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "10659209",
      "year": 1999,
      "title": "Oxygen and hydrogen gas transport through living C6 cell suspensions is faster than that in dead cells.",
      "title_en": null,
      "title_de": "Der Transport von Sauerstoff- und Wasserstoffgas durch lebende C6-Zellsuspensionen ist schneller als der in toten Zellen.",
      "journal": "Advances in experimental medicine and biology",
      "authors": "Tomita et al.",
      "author_search": "tomita tomita",
      "doi": "10.1007/978-1-4615-4717-4_85",
      "doi_url": "https://doi.org/10.1007/978-1-4615-4717-4_85",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/10659209/",
      "url": "https://h2medicine.org/studies/study-tomita-1999-oxygen-transport-through-living/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "10550517",
      "year": 1999,
      "title": "A preventive effect of a selective endothelin-A receptor antagonist, S-0139, on the erythropoietin-induced reduction of the renal cortical blood flow.",
      "title_en": null,
      "title_de": "Eine präventive Wirkung eines selektiven Endothelin-A-Rezeptor-Antagonisten, S-0139, auf die erythropoetininduzierte Verminderung des renalen kortikalen Blutflusses.",
      "journal": "Urological research",
      "authors": "Ishikawa et al.",
      "author_search": "ishikawa ishikawa",
      "doi": "10.1007/s002400050156",
      "doi_url": "https://doi.org/10.1007/s002400050156",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/10550517/",
      "url": "https://h2medicine.org/studies/study-ishikawa-1999-preventive-selective-endothelin-receptor/",
      "methods": [
        "inhalation",
        "saline-iv",
        "drinking-hrw"
      ],
      "indications": [
        "metabolic",
        "cardiovascular",
        "kidney-dialysis"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "10513557",
      "year": 1999,
      "title": "Role of calcitonin gene-related peptide and capsaicin-sensitive afferents in central thyrotropin-releasing hormone-induced hepatic hyperemia.",
      "title_en": null,
      "title_de": "Rolle des Calcitonin Gene-Related Peptide und capsaicinsensitiver Afferenzen bei der zentral durch Thyrotropin-Releasing-Hormon induzierten hepatischen Hyperämie.",
      "journal": "European journal of pharmacology",
      "authors": "Tamori et al.",
      "author_search": "tamori tamori",
      "doi": "10.1016/s0014-2999(99)00527-0",
      "doi_url": "https://doi.org/10.1016/s0014-2999(99)00527-0",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/10513557/",
      "url": "https://h2medicine.org/studies/study-tamori-1999-calcitonin-gene-related-peptide/",
      "methods": [
        "inhalation",
        "saline-iv"
      ],
      "indications": [
        "liver",
        "neurology"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "10217412",
      "year": 1999,
      "title": "CTAB-mediated enrichment for active forms of novel dimeric maxizymes.",
      "title_en": null,
      "title_de": "CTAB-vermittelte Anreicherung aktiver Formen neuartiger dimerer Maxizyme.",
      "journal": "FEBS letters",
      "authors": "Nakayama et al.",
      "author_search": "nakayama nakayama",
      "doi": "10.1016/s0014-5793(99)00325-7",
      "doi_url": "https://doi.org/10.1016/s0014-5793(99)00325-7",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/10217412/",
      "url": "https://h2medicine.org/studies/study-nakayama-1999-ctab-mediated-enrichment-active/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "9914304",
      "year": 1999,
      "title": "Anaerobic transformation of quercetin-3-glucoside by bacteria from the human intestinal tract.",
      "title_en": null,
      "title_de": "Anaerobe Transformation von Quercetin-3-glucosid durch Bakterien aus dem menschlichen Darmtrakt.",
      "journal": "Archives of microbiology",
      "authors": "Schneider et al.",
      "author_search": "schneider schneider",
      "doi": "10.1007/s002030050682",
      "doi_url": "https://doi.org/10.1007/s002030050682",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/9914304/",
      "url": "https://h2medicine.org/studies/study-schneider-1999-anaerobic-transformation-quercetin-glucoside/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "9515746",
      "year": 1998,
      "title": "13C breath test in gastroenterological practice.",
      "title_en": null,
      "title_de": "¹³C-Atemtest in der gastroenterologischen Praxis.",
      "journal": "Scandinavian journal of gastroenterology. Supplement",
      "authors": "Swart et al.",
      "author_search": "swart swart",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/9515746/",
      "url": "https://h2medicine.org/studies/study-swart-1998-13c-breath-test-gastroenterological/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "liver"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "9867093",
      "year": 1998,
      "title": "Fructose-sorbitol malabsorption and symptom provocation in irritable bowel syndrome: relationship to enteric hypersensitivity and dysmotility.",
      "title_en": null,
      "title_de": "Fructose-Sorbit-Malabsorption und Symptomprovokation beim Reizdarmsyndrom: Beziehung zu enteraler Hypersensitivität und Dysmotilität.",
      "journal": "Scandinavian journal of gastroenterology",
      "authors": "Evans et al.",
      "author_search": "evans evans",
      "doi": "10.1080/00365529850172502",
      "doi_url": "https://doi.org/10.1080/00365529850172502",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/9867093/",
      "url": "https://h2medicine.org/studies/study-evans-1998-fructose-sorbitol-malabsorption-symptom/",
      "methods": [],
      "indications": [
        "other"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "9771858",
      "year": 1998,
      "title": "Energy expenditure and net substrate utilization in men ingesting usual and high amounts of nonstarch polysaccharide.",
      "title_en": null,
      "title_de": "Energieumsatz und Netto-Substratverwertung bei Männern, die übliche und hohe Mengen an Nicht-Stärke-Polysacchariden zu sich nehmen",
      "journal": "The American journal of clinical nutrition",
      "authors": "Poppitt et al.",
      "author_search": "poppitt poppitt",
      "doi": "10.1093/ajcn/68.4.820",
      "doi_url": "https://doi.org/10.1093/ajcn/68.4.820",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/9771858/",
      "url": "https://h2medicine.org/studies/study-poppitt-1998-energy-expenditure-net-substrate/",
      "methods": [],
      "indications": [
        "metabolic",
        "sports-exercise"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "9492232",
      "year": 1998,
      "title": "A one-hour active coping stressor reduces small bowel transit time in healthy young adults.",
      "title_en": null,
      "title_de": "Ein einstündiger aktiver Bewältigungsstressor verkürzt die Dünndarmpassagezeit bei gesunden jungen Erwachsenen",
      "journal": "Psychosomatic medicine",
      "authors": "Ditto et al.",
      "author_search": "ditto ditto",
      "doi": "10.1097/00006842-199801000-00002",
      "doi_url": "https://doi.org/10.1097/00006842-199801000-00002",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/9492232/",
      "url": "https://h2medicine.org/studies/study-ditto-1998-one-hour-active-coping/",
      "methods": [],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "8870180",
      "year": 1996,
      "title": "Magnetization transfer magnetic resonance imaging: a clinical review.",
      "title_en": null,
      "title_de": "Magnetisierungstransfer-Magnetresonanztomographie: eine klinische Übersichtsarbeit",
      "journal": "Topics in magnetic resonance imaging : TMRI",
      "authors": "Mehta et al.",
      "author_search": "mehta mehta",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/8870180/",
      "url": "https://h2medicine.org/studies/study-mehta-1996-magnetization-transfer-magnetic-resonance/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "metabolic",
        "sports-exercise",
        "neurology",
        "cancer",
        "skin-aging"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "8613657",
      "year": 1996,
      "title": "How much lactose is low lactose?",
      "title_en": null,
      "title_de": "Wie viel Lactose ist wenig Lactose?",
      "journal": "Journal of the American Dietetic Association",
      "authors": "Hertzler et al.",
      "author_search": "hertzler hertzler",
      "doi": "10.1016/s0002-8223(96)00074-0",
      "doi_url": "https://doi.org/10.1016/s0002-8223(96)00074-0",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/8613657/",
      "url": "https://h2medicine.org/studies/study-hertzler-1996-how-much-lactose-low/",
      "methods": [],
      "indications": [
        "other"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "9127504",
      "year": 1996,
      "title": "Radiotoxicity of tritiated water and tritiated hydrogen.",
      "title_en": null,
      "title_de": "Radiotoxizität von tritiiertem Wasser und tritiiertem Wasserstoff",
      "journal": "Arhiv za higijenu rada i toksikologiju",
      "authors": "Franić",
      "author_search": "franić franić",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/9127504/",
      "url": "https://h2medicine.org/studies/study-franic-1996-radiotoxicity-tritiated-tritiated/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cancer",
        "respiratory"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "7796506",
      "year": 1995,
      "title": "Assessment of left-to-right intracardiac shunting by velocity-encoded, phase-difference magnetic resonance imaging. A comparison with oximetric and indicator dilution techniques.",
      "title_en": null,
      "title_de": "Beurteilung des intrakardialen Links-Rechts-Shunts mittels geschwindigkeitskodierter Phasenkontrast-Magnetresonanztomographie",
      "journal": "Circulation",
      "authors": "Hundley et al.",
      "author_search": "hundley hundley",
      "doi": "10.1161/01.cir.91.12.2955",
      "doi_url": "https://doi.org/10.1161/01.cir.91.12.2955",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/7796506/",
      "url": "https://h2medicine.org/studies/study-hundley-1995-left-right-intracardiac-shunting/",
      "methods": [],
      "indications": [
        "cardiovascular",
        "respiratory",
        "skin-aging"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "7548544",
      "year": 1995,
      "title": "Energetics of molecular hydrogen oxidation in the oral pathogen Campylobacter rectus.",
      "title_en": null,
      "title_de": "Energetik der Oxidation von molekularem Wasserstoff im oralen Pathogen Campylobacter rectus",
      "journal": "Clinical infectious diseases : an official publication of the Infectious Diseases Society of America",
      "authors": "Gillespie et al.",
      "author_search": "gillespie gillespie",
      "doi": "10.1093/clinids/20.supplement_2.s172",
      "doi_url": "https://doi.org/10.1093/clinids/20.supplement_2.s172",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/7548544/",
      "url": "https://h2medicine.org/studies/study-gillespie-1995-energetics-oxidation-oral-pathogen/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "7919894",
      "year": 1994,
      "title": "[Breath tests--a clarification of the topic].",
      "title_en": null,
      "title_de": "Atemtests: eine Klärung des Themas",
      "journal": "Bildgebung = Imaging",
      "authors": "Beglinger",
      "author_search": "beglinger beglinger",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/7919894/",
      "url": "https://h2medicine.org/studies/study-beglinger-1994-breath-tests-clarification-topic/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "7723185",
      "year": 1994,
      "title": "[Experimental and clinical studies on ischemic lesions of the large intestine].",
      "title_en": null,
      "title_de": "Experimentelle und klinische Studien zu ischämischen Läsionen des Dickdarms",
      "journal": "Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics",
      "authors": "Mizushima et al.",
      "author_search": "mizushima mizushima",
      "doi": "10.3143/geriatrics.31.835",
      "doi_url": "https://doi.org/10.3143/geriatrics.31.835",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/7723185/",
      "url": "https://h2medicine.org/studies/study-mizushima-1994-experimental-ischemic-lesions-large/",
      "methods": [],
      "indications": [
        "cardiovascular"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "7932756",
      "year": 1994,
      "title": "Drug-protein interactions. Refined structures of three sulfonamide drug complexes of human carbonic anhydrase I enzyme.",
      "title_en": null,
      "title_de": "Arzneistoff–Protein-Interaktionen: Verfeinerte Strukturen dreier Sulfonamid-Arzneistoffkomplexe des humanen Carboanhydrase-I-Enzyms",
      "journal": "Journal of molecular biology",
      "authors": "Chakravarty et al.",
      "author_search": "chakravarty chakravarty",
      "doi": "10.1006/jmbi.1994.1655",
      "doi_url": "https://doi.org/10.1006/jmbi.1994.1655",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/7932756/",
      "url": "https://h2medicine.org/studies/study-chakravarty-1994-drug-protein-interactions-refined/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "8062196",
      "year": 1994,
      "title": "Chemotherapy-induced lactose intolerance in adults.",
      "title_en": null,
      "title_de": "Chemotherapieinduzierte Lactoseintoleranz bei Erwachsenen",
      "journal": "Cancer",
      "authors": "Parnes et al.",
      "author_search": "parnes parnes",
      "doi": "10.1002/1097-0142(19940901)74:5<1629::aid-cncr2820740523>3.0.co;2-l",
      "doi_url": "https://doi.org/10.1002/1097-0142(19940901)74:5<1629::aid-cncr2820740523>3.0.co;2-l",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/8062196/",
      "url": "https://h2medicine.org/studies/study-parnes-1994-chemotherapy-induced-lactose-intolerance/",
      "methods": [],
      "indications": [
        "cancer",
        "respiratory"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "8003641",
      "year": 1994,
      "title": "A possible role for bile acid in the control of methanogenesis and the accumulation of hydrogen gas in the human colon.",
      "title_en": null,
      "title_de": "Eine mögliche Rolle von Gallensäure bei der Kontrolle der Methanogenese und der Akkumulation von Wasserstoffgas im menschlichen Kolon",
      "journal": "Journal of gastroenterology and hepatology",
      "authors": "Florin et al.",
      "author_search": "florin florin",
      "doi": "10.1111/j.1440-1746.1994.tb01228.x",
      "doi_url": "https://doi.org/10.1111/j.1440-1746.1994.tb01228.x",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/8003641/",
      "url": "https://h2medicine.org/studies/study-florin-1994-possible-bile-acid-control/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "8041275",
      "year": 1994,
      "title": "Regeneration of functional hemoglobin from partially oxidized hemoglobin in the presence of molecular hydrogen and a multicomponent redox catalyst.",
      "title_en": null,
      "title_de": "Regeneration von funktionellem Hämoglobin aus teilweise oxidiertem Hämoglobin in Gegenwart von molekularem Wasserstoff und einem Mehrkomponenten-Redoxkatalysator",
      "journal": "Methods in enzymology",
      "authors": "McGown et al.",
      "author_search": "mcgown mc gown",
      "doi": "10.1016/0076-6879(94)31037-8",
      "doi_url": "https://doi.org/10.1016/0076-6879(94)31037-8",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/8041275/",
      "url": "https://h2medicine.org/studies/study-mcgown-1994-regeneration-functional-hemoglobin-partially/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "7949764",
      "year": 1994,
      "title": "Evaluation of tracheal mucosal blood flow during an extended radical operation for esophageal carcinoma: clinical and experimental studies.",
      "title_en": null,
      "title_de": "Beurteilung des trachealen Mukosa-Blutflusses während einer erweiterten Radikaloperation bei Ösophaguskarzinom",
      "journal": "Surgery today",
      "authors": "Nakahara et al.",
      "author_search": "nakahara nakahara",
      "doi": "10.1007/bf01833720",
      "doi_url": "https://doi.org/10.1007/bf01833720",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/7949764/",
      "url": "https://h2medicine.org/studies/study-nakahara-1994-tracheal-mucosal-blood-flow/",
      "methods": [],
      "indications": [
        "cardiovascular",
        "cancer",
        "respiratory"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "8112709",
      "year": 1993,
      "title": "[Effect of endogenous opioids on gastric functions in man].",
      "title_en": null,
      "title_de": "Wirkung endogener Opioide auf die Magenfunktionen beim Menschen",
      "journal": "[Hokkaido igaku zasshi] The Hokkaido journal of medical science",
      "authors": "Suzuki",
      "author_search": "suzuki suzuki",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/8112709/",
      "url": "https://h2medicine.org/studies/study-suzuki-1993-endogenous-opioids-gastric-functions/",
      "methods": [],
      "indications": [
        "neurology"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "8249850",
      "year": 1993,
      "title": "Hydrogen inhalation for detecting intracardiac left-to-right shunting in adults.",
      "title_en": null,
      "title_de": "Wasserstoffinhalation zum Nachweis intrakardialer Links-Rechts-Shunts bei Erwachsenen",
      "journal": "The American journal of cardiology",
      "authors": "Glamann et al.",
      "author_search": "glamann glamann",
      "doi": "10.1016/0002-9149(93)90890-o",
      "doi_url": "https://doi.org/10.1016/0002-9149(93)90890-o",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/8249850/",
      "url": "https://h2medicine.org/studies/study-glamann-1993-inhalation-detecting-intracardiac-left/",
      "methods": [],
      "indications": [
        "cardiovascular",
        "respiratory"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "8357854",
      "year": 1993,
      "title": "A simplified method for deuterium/hydrogen isotope ratio measurements on water samples of biological origin.",
      "title_en": null,
      "title_de": "Eine vereinfachte Methode zur Messung des Deuterium/Wasserstoff-Isotopenverhältnisses an Wasserproben biologischen Ursprungs",
      "journal": "Biological mass spectrometry",
      "authors": "Scrimgeour et al.",
      "author_search": "scrimgeour scrimgeour",
      "doi": "10.1002/bms.1200220704",
      "doi_url": "https://doi.org/10.1002/bms.1200220704",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/8357854/",
      "url": "https://h2medicine.org/studies/study-scrimgeour-1993-simplified-method-deuterium-isotope/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "1489103",
      "year": 1992,
      "title": "Regeneration of functional hemoglobin from iron(III) hemoglobin by reduction with hydrogen and a heterogeneous catalyst.",
      "title_en": null,
      "title_de": "Regeneration von funktionellem Hämoglobin aus Eisen(III)-Hämoglobin durch Reduktion mit Wasserstoff und einem heterogenen Katalysator",
      "journal": "Analytical biochemistry",
      "authors": "McGown et al.",
      "author_search": "mcgown mc gown",
      "doi": "10.1016/0003-2697(92)90505-2",
      "doi_url": "https://doi.org/10.1016/0003-2697(92)90505-2",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/1489103/",
      "url": "https://h2medicine.org/studies/study-mcgown-1992-regeneration-functional-hemoglobin-iron/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "1318087",
      "year": 1992,
      "title": "Crystallographic changes in calcium phosphates during plasma-spraying.",
      "title_en": null,
      "title_de": "Kristallographische Veränderungen in Calciumphosphaten während des Plasmaspritzens",
      "journal": "Biomaterials",
      "authors": "Ellies et al.",
      "author_search": "ellies ellies",
      "doi": "10.1016/0142-9612(92)90055-s",
      "doi_url": "https://doi.org/10.1016/0142-9612(92)90055-s",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/1318087/",
      "url": "https://h2medicine.org/studies/study-ellies-1992-crystallographic-changes-calcium-phosphates/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "1313759",
      "year": 1992,
      "title": "A new zinc product for the reduction of water in physiological fluids to hydrogen gas for 2H/1H isotope ratio measurements.",
      "title_en": null,
      "title_de": "Ein neues Zinkprodukt zur Reduktion von Wasser in physiologischen Flüssigkeiten zu Wasserstoffgas für ²H/¹H-Isotopenverhältnis-Messungen",
      "journal": "European journal of clinical nutrition",
      "authors": "Wong et al.",
      "author_search": "wong wong",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/1313759/",
      "url": "https://h2medicine.org/studies/study-wong-1992-zinc-product-reduction-physiological/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "1792946",
      "year": 1991,
      "title": "No evidence for an effect of lactase deficiency on bone mass in pre- or postmenopausal women.",
      "title_en": null,
      "title_de": "Kein Hinweis auf einen Effekt eines Lactasemangels auf die Knochenmasse bei prä- oder postmenopausalen Frauen",
      "journal": "Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research",
      "authors": "Slemenda et al.",
      "author_search": "slemenda slemenda",
      "doi": "10.1002/jbmr.5650061214",
      "doi_url": "https://doi.org/10.1002/jbmr.5650061214",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/1792946/",
      "url": "https://h2medicine.org/studies/study-slemenda-1991-evidence-lactase-deficiency-bone/",
      "methods": [],
      "indications": [
        "metabolic",
        "womens-health"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "1651893",
      "year": 1991,
      "title": "[Protective effect of rebamipide (OPC-12759) on the gastric mucosa in rats and humans].",
      "title_en": null,
      "title_de": "Schützende Wirkung von Rebamipid (OPC-12759) auf die Magenschleimhaut bei Ratten und Menschen",
      "journal": "Nihon yakurigaku zasshi. Folia pharmacologica Japonica",
      "authors": "Kawano et al.",
      "author_search": "kawano kawano",
      "doi": "10.1254/fpj.97.6_371",
      "doi_url": "https://doi.org/10.1254/fpj.97.6_371",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/1651893/",
      "url": "https://h2medicine.org/studies/study-kawano-1991-protective-rebamipide-opc-12759/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "2379871",
      "year": 1990,
      "title": "Alternative pathways for hydrogen disposal during fermentation in the human colon.",
      "title_en": null,
      "title_de": "Alternative Wege zur Wasserstoffbeseitigung während der Fermentation im menschlichen Kolon.",
      "journal": "Gut",
      "authors": "Gibson et al.",
      "author_search": "gibson gibson",
      "doi": "10.1136/gut.31.6.679",
      "doi_url": "https://doi.org/10.1136/gut.31.6.679",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/2379871/",
      "url": "https://h2medicine.org/studies/study-gibson-1990-alternative-pathways-disposal-during/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "2191785",
      "year": 1990,
      "title": "Assessment of the sensitivity of hydrogen inhalation in the detection of left-to-right shunting.",
      "title_en": null,
      "title_de": "Beurteilung der Sensitivität der Wasserstoffinhalation beim Nachweis von Links-Rechts-Shunts",
      "journal": "Catheterization and cardiovascular diagnosis",
      "authors": "Flores et al.",
      "author_search": "flores flores",
      "doi": "10.1002/ccd.1810200206",
      "doi_url": "https://doi.org/10.1002/ccd.1810200206",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/2191785/",
      "url": "https://h2medicine.org/studies/study-flores-1990-sensitivity-inhalation-detection-left/",
      "methods": [],
      "indications": [
        "cardiovascular",
        "respiratory"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "2365796",
      "year": 1990,
      "title": "[Measurement of hepatic blood flow by the hydrogen gas clearance method. Experimental and clinical observations].",
      "title_en": null,
      "title_de": "Messung des hepatischen Blutflusses mittels Wasserstoffgas-Clearance-Methode: Experimentelle und klinische Beobachtungen",
      "journal": "Nihon Ika Daigaku zasshi",
      "authors": "Makino",
      "author_search": "makino makino",
      "doi": "10.1272/jnms1923.57.137",
      "doi_url": "https://doi.org/10.1272/jnms1923.57.137",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/2365796/",
      "url": "https://h2medicine.org/studies/study-makino-1990-measurement-hepatic-blood-flow/",
      "methods": [],
      "indications": [
        "liver",
        "sports-exercise",
        "cancer"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "2314375",
      "year": 1990,
      "title": "[Correlation between gastric microcirculation and mucosal injury after surgical therapy of esophageal varices].",
      "title_en": null,
      "title_de": "Korrelation zwischen gastraler Mikrozirkulation und Mukosaschädigung nach chirurgischer Therapie von Ösophagusvarizen.",
      "journal": "Nihon Geka Gakkai zasshi",
      "authors": "Mitarai et al.",
      "author_search": "mitarai mitarai",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/2314375/",
      "url": "https://h2medicine.org/studies/study-mitarai-1990-correlation-between-gastric-microcirculation/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cardiovascular"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "2666015",
      "year": 1989,
      "title": "Effects of Escherichia coli spheroplast formation on assays of H2 and adenosine triphosphate based ampicillin susceptibility tests.",
      "title_en": null,
      "title_de": "Auswirkungen der Sphäroplastenbildung von Escherichia coli auf H₂- und Adenosintriphosphat-basierte Ampicillin-Empfindlichkeitstests.",
      "journal": "Diagnostic microbiology and infectious disease",
      "authors": "Hörnsten et al.",
      "author_search": "hörnsten hörnsten",
      "doi": "10.1016/0732-8893(89)90009-6",
      "doi_url": "https://doi.org/10.1016/0732-8893(89)90009-6",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/2666015/",
      "url": "https://h2medicine.org/studies/study-hoernsten-1989-escherichia-coli-spheroplast-formation/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "2496538",
      "year": 1989,
      "title": "GasPak Plus versus Anaerocult A--two carbon dioxide/hydrogen systems for cultivation of anaerobes.",
      "title_en": null,
      "title_de": "GasPak Plus versus Anaerocult A – zwei Kohlendioxid/Wasserstoff-Systeme zur Kultivierung von Anaerobiern.",
      "journal": "Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology",
      "authors": "Heizmann et al.",
      "author_search": "heizmann heizmann",
      "doi": "10.1016/s0176-6724(89)80022-7",
      "doi_url": "https://doi.org/10.1016/s0176-6724(89)80022-7",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/2496538/",
      "url": "https://h2medicine.org/studies/study-heizmann-1989-gaspak-plus-versus-anaerocult/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "metabolic",
        "sports-exercise",
        "neurology",
        "cardiovascular"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "3140651",
      "year": 1988,
      "title": "The acceptability of milk and milk products in populations with a high prevalence of lactose intolerance.",
      "title_en": null,
      "title_de": "Die Akzeptanz von Milch und Milchprodukten in Bevölkerungsgruppen mit hoher Prävalenz von Lactoseintoleranz.",
      "journal": "The American journal of clinical nutrition",
      "authors": "Scrimshaw et al.",
      "author_search": "scrimshaw scrimshaw",
      "doi": "10.1093/ajcn/48.4.1142",
      "doi_url": "https://doi.org/10.1093/ajcn/48.4.1142",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/3140651/",
      "url": "https://h2medicine.org/studies/study-scrimshaw-1988-acceptability-milk-milk-products/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "2831734",
      "year": 1988,
      "title": "Role of blood flow in gastric acid secretion.",
      "title_en": null,
      "title_de": "Rolle des Blutflusses bei der Magensäuresekretion.",
      "journal": "The American journal of physiology",
      "authors": "Holm et al.",
      "author_search": "holm holm",
      "doi": "10.1152/ajpgi.1988.254.3.g281",
      "doi_url": "https://doi.org/10.1152/ajpgi.1988.254.3.g281",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/2831734/",
      "url": "https://h2medicine.org/studies/study-holm-1988-blood-flow-gastric-acid/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "2849711",
      "year": 1988,
      "title": "Dietary fibre and health: the role of hydrogen production.",
      "title_en": null,
      "title_de": "Ballaststoffe und Gesundheit: die Rolle der Wasserstoffproduktion",
      "journal": "Medical hypotheses",
      "authors": "Neale",
      "author_search": "neale neale",
      "doi": "10.1016/0306-9877(88)90091-6",
      "doi_url": "https://doi.org/10.1016/0306-9877(88)90091-6",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/2849711/",
      "url": "https://h2medicine.org/studies/study-neale-1988-dietary-fibre-health-production/",
      "methods": [],
      "indications": [
        "skin-aging",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "byproduct"
    },
    {
      "pmid": "3132563",
      "year": 1988,
      "title": "Effect of endocrine treatment on prostatic blood flow in patients with prostatic adenocarcinoma.",
      "title_en": null,
      "title_de": "Wirkung einer endokrinen Behandlung auf den prostatischen Blutfluss bei Patienten mit prostatischem Adenokarzinom",
      "journal": "The Journal of urology",
      "authors": "Toma et al.",
      "author_search": "toma toma",
      "doi": "10.1016/s0022-5347(17)41495-9",
      "doi_url": "https://doi.org/10.1016/s0022-5347(17)41495-9",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/3132563/",
      "url": "https://h2medicine.org/studies/study-toma-1988-endocrine-prostatic-blood-flow/",
      "methods": [],
      "indications": [
        "neurology",
        "cancer"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "3348155",
      "year": 1988,
      "title": "All yogurts are not created equal.",
      "title_en": null,
      "title_de": "Nicht alle Joghurts sind gleich",
      "journal": "The American journal of clinical nutrition",
      "authors": "Wytock et al.",
      "author_search": "wytock wytock",
      "doi": "10.1093/ajcn/47.3.454",
      "doi_url": "https://doi.org/10.1093/ajcn/47.3.454",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/3348155/",
      "url": "https://h2medicine.org/studies/study-wytock-1988-all-yogurts-not-created/",
      "methods": [],
      "indications": [
        "other"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "2963569",
      "year": 1988,
      "title": "Endoscopic measurement of gastric mucosal blood flow by laser Doppler velocimetry: effect of chronic esophageal variceal sclerosis.",
      "title_en": null,
      "title_de": "Endoskopische Messung des Magenmukosa-Blutflusses mittels Laser-Doppler-Velocimetrie: Wirkung der chronischen Ösophagusvarizen-Sklerosierung",
      "journal": "The American surgeon",
      "authors": "Chung et al.",
      "author_search": "chung chung",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/2963569/",
      "url": "https://h2medicine.org/studies/study-chung-1988-endoscopic-measurement-gastric-mucosal/",
      "methods": [],
      "indications": [
        "cardiovascular"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "3653647",
      "year": 1987,
      "title": "Gastroduodenal mucosal hemodynamics by endoscopic reflectance spectrophotometry.",
      "title_en": null,
      "title_de": "Gastroduodenale Mukosa-Hämodynamik mittels endoskopischer Reflexionsspektrophotometrie",
      "journal": "Gastrointestinal endoscopy",
      "authors": "Leung et al.",
      "author_search": "leung leung",
      "doi": "10.1016/s0016-5107(87)71599-5",
      "doi_url": "https://doi.org/10.1016/s0016-5107(87)71599-5",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/3653647/",
      "url": "https://h2medicine.org/studies/study-leung-1987-gastroduodenal-mucosal-hemodynamics-endoscopic/",
      "methods": [],
      "indications": [
        "liver",
        "cardiovascular"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "3303890",
      "year": 1987,
      "title": "Detection of intracardiac left-to-right shunting in adults: a prospective analysis of the variability of the standard indocyanine green technique in patients without shunting.",
      "title_en": null,
      "title_de": "Nachweis intrakardialer Links-Rechts-Shunts bei Erwachsenen: eine prospektive Analyse der Variabilität der Standard-Indocyaningrün-Technik",
      "journal": "The American journal of cardiology",
      "authors": "Niggemann et al.",
      "author_search": "niggemann niggemann",
      "doi": "10.1016/0002-9149(87)90242-6",
      "doi_url": "https://doi.org/10.1016/0002-9149(87)90242-6",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/3303890/",
      "url": "https://h2medicine.org/studies/study-niggemann-1987-detection-intracardiac-left-right/",
      "methods": [],
      "indications": [
        "cardiovascular",
        "respiratory"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "3578092",
      "year": 1987,
      "title": "Deuterium and oxygen-18 measurements on microliter samples of urine, plasma, saliva, and human milk.",
      "title_en": null,
      "title_de": "Deuterium- und Sauerstoff-18-Messungen an Mikroliterproben von Urin, Plasma, Speichel und Muttermilch.",
      "journal": "The American journal of clinical nutrition",
      "authors": "Wong et al.",
      "author_search": "wong wong",
      "doi": "10.1093/ajcn/45.5.905",
      "doi_url": "https://doi.org/10.1093/ajcn/45.5.905",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/3578092/",
      "url": "https://h2medicine.org/studies/study-wong-1987-deuterium-oxygen-measurements-microliter/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "metabolic"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "3095080",
      "year": 1986,
      "title": "Comparison of oral lavage methods for preoperative colonic cleansing.",
      "title_en": null,
      "title_de": "Vergleich oraler Lavage-Methoden zur präoperativen Darmreinigung",
      "journal": "Diseases of the colon and rectum",
      "authors": "Beck et al.",
      "author_search": "beck beck",
      "doi": "10.1007/bf02555311",
      "doi_url": "https://doi.org/10.1007/bf02555311",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/3095080/",
      "url": "https://h2medicine.org/studies/study-beck-1986-comparison-oral-lavage-methods/",
      "methods": [],
      "indications": [
        "other"
      ],
      "evidence_level": 3,
      "human": true,
      "therapeutic": false,
      "h2category": "byproduct"
    },
    {
      "pmid": "3749634",
      "year": 1986,
      "title": "[Measurement of skin blood flow using inhaled hydrogen gas clearance method].",
      "title_en": null,
      "title_de": "Messung des Haut-Blutflusses mittels inhalierter Wasserstoffgas-Clearance-Methode",
      "journal": "Kokyu to junkan. Respiration & circulation",
      "authors": "Nohara et al.",
      "author_search": "nohara nohara",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/3749634/",
      "url": "https://h2medicine.org/studies/study-nohara-1986-measurement-skin-blood-flow/",
      "methods": [],
      "indications": [
        "skin-aging"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "3943456",
      "year": 1986,
      "title": "Hemodynamics of the gastric mucosa and gastric ulceration in rats and in patients with gastric ulcer.",
      "title_en": null,
      "title_de": "Hämodynamik der Magenmukosa und Magenulzeration bei Ratten und bei Patienten mit Magenulkus.",
      "journal": "Digestive diseases and sciences",
      "authors": "Sato et al.",
      "author_search": "sato sato",
      "doi": "10.1007/bf01309321",
      "doi_url": "https://doi.org/10.1007/bf01309321",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/3943456/",
      "url": "https://h2medicine.org/studies/study-sato-1986-hemodynamics-gastric-mucosa-gastric/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "3485763",
      "year": 1986,
      "title": "[Etiopathogenesis of hemorrhagic gastritis after esophageal transection extended devascularization in variceal patients].",
      "title_en": null,
      "title_de": "Ätiopathogenese der hämorrhagischen Gastritis nach Ösophagustransektion mit erweiterter Devaskularisation bei Varizenpatienten",
      "journal": "Nihon Geka Gakkai zasshi",
      "authors": "Satani",
      "author_search": "satani satani",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/3485763/",
      "url": "https://h2medicine.org/studies/study-satani-1986-etiopathogenesis-hemorrhagic-gastritis-after/",
      "methods": [],
      "indications": [
        "cardiovascular"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "2990189",
      "year": 1985,
      "title": "Dietary fiber effects on passage rate and breath hydrogen.",
      "title_en": null,
      "title_de": "Auswirkungen von Ballaststoffen auf die Passagerate und den Atemwasserstoff",
      "journal": "The American journal of clinical nutrition",
      "authors": "Hanson et al.",
      "author_search": "hanson hanson",
      "doi": "10.1093/ajcn/42.1.44",
      "doi_url": "https://doi.org/10.1093/ajcn/42.1.44",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/2990189/",
      "url": "https://h2medicine.org/studies/study-hanson-1985-dietary-fiber-passage-rate/",
      "methods": [],
      "indications": [
        "other"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "3989351",
      "year": 1985,
      "title": "Intestinal metabolism of a random-bonded polyglucose bulking agent in humans: in vitro and in vivo studies of hydrogen evolution.",
      "title_en": null,
      "title_de": "Intestinaler Stoffwechsel eines zufallsverknüpften Polyglucose-Füllstoffs beim Menschen: In-vitro- und In-vivo-Studien zur Wasserstoffentwicklung",
      "journal": "The Journal of laboratory and clinical medicine",
      "authors": "Solomons et al.",
      "author_search": "solomons solomons",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/3989351/",
      "url": "https://h2medicine.org/studies/study-solomons-1985-intestinal-metabolism-random-bonded/",
      "methods": [],
      "indications": [
        "fundamentals-safety"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "2578223",
      "year": 1985,
      "title": "Development of carbohydrate absorption in the fetus and neonate.",
      "title_en": null,
      "title_de": "Entwicklung der Kohlenhydratabsorption beim Fetus und Neugeborenen",
      "journal": "Pediatrics",
      "authors": "Mobassaleh et al.",
      "author_search": "mobassaleh mobassaleh",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/2578223/",
      "url": "https://h2medicine.org/studies/study-mobassaleh-1985-development-carbohydrate-absorption-fetus/",
      "methods": [],
      "indications": [
        "sports-exercise",
        "pregnancy"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "6530800",
      "year": 1984,
      "title": "[Endoscopic measurement of gastric mucosal blood flow by hydrogen gas generated by electrolysis--comparison with H2-inhalation method].",
      "title_en": null,
      "title_de": "Endoskopische Messung des Magenmukosa-Blutflusses mittels durch Elektrolyse erzeugtem Wasserstoffgas – Vergleich mit der H₂-Inhalationsmethode",
      "journal": "Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology",
      "authors": "Nishiwaki et al.",
      "author_search": "nishiwaki nishiwaki",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/6530800/",
      "url": "https://h2medicine.org/studies/study-nishiwaki-1984-endoscopic-measurement-gastric-mucosal/",
      "methods": [],
      "indications": [
        "other"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "6745722",
      "year": 1984,
      "title": "Is raised breath hydrogen related to the pathogenesis of pneumatosis coli?",
      "title_en": null,
      "title_de": "Steht erhöhter Atemwasserstoff im Zusammenhang mit der Pathogenese der Pneumatosis coli?",
      "journal": "Gut",
      "authors": "Read et al.",
      "author_search": "read read",
      "doi": "10.1136/gut.25.8.839",
      "doi_url": "https://doi.org/10.1136/gut.25.8.839",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/6745722/",
      "url": "https://h2medicine.org/studies/study-read-1984-raised-breath-related-pathogenesis/",
      "methods": [],
      "indications": [
        "sports-exercise"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "6745599",
      "year": 1984,
      "title": "Endoscopical determination of gastric mucosal blood flow by the crossed thermocouple method.",
      "title_en": null,
      "title_de": "Endoskopische Bestimmung des Magenmukosa-Blutflusses mittels der gekreuzten Thermoelement-Methode",
      "journal": "Gastroenterologia Japonica",
      "authors": "Hiramatsu et al.",
      "author_search": "hiramatsu hiramatsu",
      "doi": "10.1007/bf02779172",
      "doi_url": "https://doi.org/10.1007/bf02779172",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/6745599/",
      "url": "https://h2medicine.org/studies/study-hiramatsu-1984-endoscopical-determination-gastric-mucosal/",
      "methods": [],
      "indications": [
        "other"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "6717636",
      "year": 1984,
      "title": "[The determination of hydrogen gas in the expired air for the diagnosis of carbohydrate resorption disorders].",
      "title_en": null,
      "title_de": "Die Bestimmung von Wasserstoffgas in der Ausatemluft zur Diagnose von Kohlenhydratresorptionsstörungen",
      "journal": "Nederlands tijdschrift voor geneeskunde",
      "authors": "Dolmans et al.",
      "author_search": "dolmans dolmans",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/6717636/",
      "url": "https://h2medicine.org/studies/study-dolmans-1984-determination-expired-air-diagnosis/",
      "methods": [],
      "indications": [
        "other"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "6749107",
      "year": 1984,
      "title": "[Experimental and clinical studies on esophago-gastric hemodynamics before and after devascularization for esophageal varices].",
      "title_en": null,
      "title_de": "Experimentelle und klinische Studien zur ösophago-gastralen Hämodynamik vor und nach Devaskularisation bei Ösophagusvarizen",
      "journal": "Nihon Geka Gakkai zasshi",
      "authors": "Toyama",
      "author_search": "toyama toyama",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/6749107/",
      "url": "https://h2medicine.org/studies/study-toyama-1984-experimental-esophago-gastric-hemodynamics/",
      "methods": [],
      "indications": [
        "liver",
        "cardiovascular"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "6715939",
      "year": 1984,
      "title": "[The cervical blood flow using hydrogen gas clearance method].",
      "title_en": null,
      "title_de": "Der zervikale Blutfluss mittels Wasserstoffgas-Clearance-Methode",
      "journal": "Nihon Sanka Fujinka Gakkai zasshi",
      "authors": "Sakiyama",
      "author_search": "sakiyama sakiyama",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/6715939/",
      "url": "https://h2medicine.org/studies/study-sakiyama-1984-cervical-blood-flow-clearance/",
      "methods": [],
      "indications": [
        "sports-exercise",
        "pregnancy"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "6624949",
      "year": 1983,
      "title": "Transient solutions of equations for countercurrent capillary exchange.",
      "title_en": null,
      "title_de": "Transiente Lösungen von Gleichungen für den Gegenstrom-Kapillaraustausch.",
      "journal": "The American journal of physiology",
      "authors": "Homer et al.",
      "author_search": "homer homer",
      "doi": "10.1152/ajpregu.1983.245.4.r534",
      "doi_url": "https://doi.org/10.1152/ajpregu.1983.245.4.r534",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/6624949/",
      "url": "https://h2medicine.org/studies/study-homer-1983-transient-solutions-equations-countercurrent/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cardiovascular",
        "kidney-dialysis"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "6223807",
      "year": 1983,
      "title": "Laparoscopic measurement of pancreatic blood flow.",
      "title_en": null,
      "title_de": "Laparoskopische Messung des pankreatischen Blutflusses.",
      "journal": "Endoscopy",
      "authors": "Ishida et al.",
      "author_search": "ishida ishida",
      "doi": "10.1055/s-2007-1021480",
      "doi_url": "https://doi.org/10.1055/s-2007-1021480",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/6223807/",
      "url": "https://h2medicine.org/studies/study-ishida-1983-laparoscopic-measurement-pancreatic-blood/",
      "methods": [],
      "indications": [
        "liver"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "6855267",
      "year": 1983,
      "title": "The fatty acyl chain composition of human normal and leukaemic lymphocytes and its modulation by specialised hydrogenation.",
      "title_en": null,
      "title_de": "Die Fettsäure-Acylketten-Zusammensetzung normaler und leukämischer menschlicher Lymphozyten und ihre Modulation durch spezialisierte Hydrierung.",
      "journal": "Leukemia research",
      "authors": "Peel et al.",
      "author_search": "peel peel",
      "doi": "10.1016/0145-2126(83)90009-7",
      "doi_url": "https://doi.org/10.1016/0145-2126(83)90009-7",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/6855267/",
      "url": "https://h2medicine.org/studies/study-peel-1983-fatty-acyl-chain-composition/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "cancer"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "6620060",
      "year": 1983,
      "title": "Breath hydrogen analysis: a review of the methodologies and clinical applications.",
      "title_en": null,
      "title_de": "Atemwasserstoff-Analyse: eine Übersichtsarbeit zu den Methodiken und klinischen Anwendungen.",
      "journal": "Journal of pediatric gastroenterology and nutrition",
      "authors": "Ostrander et al.",
      "author_search": "ostrander ostrander",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/6620060/",
      "url": "https://h2medicine.org/studies/study-ostrander-1983-breath-analysis-review-methodologies/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "7054042",
      "year": 1982,
      "title": "Contact electrode method in hydrogen gas clearance technique: a new method for determination of regional gastric mucosal blood flow in animals and humans.",
      "title_en": null,
      "title_de": "Kontaktelektroden-Methode in der Wasserstoffgas-Clearance-Technik: eine neue Methode zur Bestimmung des regionalen Magenmukosa-Blutflusses bei Tieren und Menschen.",
      "journal": "Gastroenterology",
      "authors": "Murakami et al.",
      "author_search": "murakami murakami",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/7054042/",
      "url": "https://h2medicine.org/studies/study-murakami-1982-contact-electrode-method-clearance/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "10317",
      "year": 1976,
      "title": "Characterization of bacteroides melaninogenicus.",
      "title_en": null,
      "title_de": "Charakterisierung von Bacteroides melaninogenicus.",
      "journal": "Journal of clinical microbiology",
      "authors": "Harding et al.",
      "author_search": "harding harding",
      "doi": "10.1128/jcm.4.4.354-359.1976",
      "doi_url": "https://doi.org/10.1128/jcm.4.4.354-359.1976",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/10317/",
      "url": "https://h2medicine.org/studies/study-harding-1976-characterization-bacteroides-melaninogenicus/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "5009552",
      "year": 1972,
      "title": "Measurements in man of focal intracerebral blood flow around depth-electrodes with hydrogen gas.",
      "title_en": null,
      "title_de": "Messungen des fokalen intrazerebralen Blutflusses um Tiefenelektroden beim Menschen mit Wasserstoffgas.",
      "journal": "Progress in brain research",
      "authors": "Sem-Jacobsen et al.",
      "author_search": "sem-jacobsen sem-jacobsen",
      "doi": "10.1016/s0079-6123(08)60090-4",
      "doi_url": "https://doi.org/10.1016/s0079-6123(08)60090-4",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/5009552/",
      "url": "https://h2medicine.org/studies/study-semjacobsen-1972-measurements-man-focal-intracerebral/",
      "methods": [],
      "indications": [
        "other"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "5790483",
      "year": 1969,
      "title": "Production and excretion of hydrogen gas in man.",
      "title_en": null,
      "title_de": "Produktion und Ausscheidung von Wasserstoffgas beim Menschen.",
      "journal": "The New England journal of medicine",
      "authors": "Levitt",
      "author_search": "levitt levitt",
      "doi": "10.1056/nejm196907172810303",
      "doi_url": "https://doi.org/10.1056/nejm196907172810303",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/5790483/",
      "url": "https://h2medicine.org/studies/study-levitt-1969-production-excretion-man/",
      "methods": [],
      "indications": [
        "other"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "byproduct"
    },
    {
      "pmid": "4889689",
      "year": 1969,
      "title": "[Hydrogen inhalation curves in cardiologic diagnosis of children].",
      "title_en": null,
      "title_de": "Wasserstoffinhalationskurven in der kardiologischen Diagnostik bei Kindern.",
      "journal": "Nederlands tijdschrift voor geneeskunde",
      "authors": "Muller et al.",
      "author_search": "muller muller",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/4889689/",
      "url": "https://h2medicine.org/studies/study-muller-1969-inhalation-curves-cardiologic-diagnosis/",
      "methods": [],
      "indications": [
        "cardiovascular"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "5378111",
      "year": 1969,
      "title": "Measurement of human uterine cervical blood flow by local hydrogen gas clearance.",
      "title_en": null,
      "title_de": "Messung des Blutflusses der menschlichen Cervix uteri mittels lokaler Wasserstoffgas-Clearance.",
      "journal": "Acta obstetricia et gynecologica Scandinavica",
      "authors": "Klingenberg et al.",
      "author_search": "klingenberg klingenberg",
      "doi": "10.3109/00016346909156661",
      "doi_url": "https://doi.org/10.3109/00016346909156661",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/5378111/",
      "url": "https://h2medicine.org/studies/study-klingenberg-1969-measurement-uterine-cervical-blood/",
      "methods": [],
      "indications": [
        "other"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "5856743",
      "year": 1965,
      "title": "The use of hydrogen inhalation in the detection of intrcardiac shunts.",
      "title_en": null,
      "title_de": "Die Anwendung der Wasserstoffinhalation beim Nachweis intrakardialer Shunts.",
      "journal": "South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde",
      "authors": "Heimann et al.",
      "author_search": "heimann heimann",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/5856743/",
      "url": "https://h2medicine.org/studies/study-heimann-1965-use-inhalation-detection-intrcardiac/",
      "methods": [],
      "indications": [
        "other"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "5294201",
      "year": 1965,
      "title": "[Detection of minimal left-right shunts by hydrogen inhalation].",
      "title_en": null,
      "title_de": "Nachweis minimaler Links-Rechts-Shunts durch Wasserstoffinhalation.",
      "journal": "Acta cardiologica",
      "authors": "Cosyns et al.",
      "author_search": "cosyns cosyns",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/5294201/",
      "url": "https://h2medicine.org/studies/study-cosyns-1965-detection-minimal-left-right/",
      "methods": [],
      "indications": [
        "other"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "14068764",
      "year": 1963,
      "title": "THE CLINICAL USEFULNESS OF HYDROGEN GAS AS AN INDICATOR OF LEFT-TO-RIGHT SHUNTS.",
      "title_en": null,
      "title_de": "Der klinische Nutzen von Wasserstoffgas als Indikator für Links-Rechts-Shunts.",
      "journal": "Circulation",
      "authors": "HUGENHOLTZ et al.",
      "author_search": "hugenholtz hugenholtz",
      "doi": "10.1161/01.cir.28.4.542",
      "doi_url": "https://doi.org/10.1161/01.cir.28.4.542",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/14068764/",
      "url": "https://h2medicine.org/studies/study-hugenholtz-1963-usefulness-indicator-left-right/",
      "methods": [],
      "indications": [
        "other"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "13810467",
      "year": 1959,
      "title": "Left-to-right shunt detection by an intravascular electrode with hydrogen as an indicator.",
      "title_en": null,
      "title_de": "Nachweis von Links-Rechts-Shunts mittels einer intravaskulären Elektrode mit Wasserstoff als Indikator.",
      "journal": "Science (New York, N.Y.)",
      "authors": "CLARK LC Jr et al.",
      "author_search": "clark lc jr clark lc jr",
      "doi": "10.1126/science.130.3377.709",
      "doi_url": "https://doi.org/10.1126/science.130.3377.709",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/13810467/",
      "url": "https://h2medicine.org/studies/study-clarklcjr-1959-left-right-shunt-detection/",
      "methods": [],
      "indications": [
        "cardiovascular",
        "respiratory"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "20287912",
      "year": 1947,
      "title": "On the activation of molecular hydrogen by Proteus vulgaris.",
      "title_en": null,
      "title_de": "Über die Aktivierung von molekularem Wasserstoff durch Proteus vulgaris.",
      "journal": "The Journal of biological chemistry",
      "authors": "FARKAS et al.",
      "author_search": "farkas farkas",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/20287912/",
      "url": "https://h2medicine.org/studies/study-farkas-1947-activation-proteus-vulgaris/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    }
  ]
}
