{ "name": "State of H₂ human studies 2026", "version": "2026.1", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "source": "https://h2medicine.org", "description": "Curated overview of every peer-reviewed human study on molecular hydrogen (H₂), compiled from PubMed and CrossRef. Facts, freely reusable with attribution.", "count": 292, "language": "en", "other_language_url": "https://h2medizin.org", "studies": [ { "pmid": "42734448", "year": 2027, "title": "Hydrogen-rich water combined with traditional Chinese medicine compound in the treatment of kidney stones: a randomized controlled prospective clinical trial.", "authors": "Yin et al.", "journal": "Medical gas research", "doi": "10.4103/mgr.MEDGASRES-D-26-00067", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/42734448/", "doi_url": "https://doi.org/10.4103/mgr.MEDGASRES-D-26-00067", "page_url": "https://h2medicine.org/studies/study-yin-2027-chinese-medicine-kidney-stones/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Kidney / Dialysis", "indication_keys": "kidney-dialysis", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "41401441", "year": 2026, "title": "Sixty-minute inhalation of molecular hydrogen decreases blood oxygen saturation but does not alter autonomic cardiac regulation at rest in healthy females: a randomized, double-blind, placebo-controlled crossover study", "authors": "Grepl et al.", "journal": "Canadian Journal of Physiology and Pharmacology", "doi": "10.1139/cjpp-2025-0228", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/41401441/", "doi_url": "https://doi.org/10.1139/cjpp-2025-0228", "page_url": "https://h2medicine.org/studies/study-grepl-2026-60-minute-inhalation-blood-oxygen-saturation-cardiac-regulation/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Fundamentals; Cardiovascular; Women's health", "indication_keys": "fundamentals; cardiovascular; womens-health", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "41754211", "year": 2026, "title": "Redox Water Consumption Attenuates Exercise-Induced Inflammation and Oxidative Stress in Physically Active Adults: A Randomized Controlled Trial", "authors": "Stolecka-Warzecha et al.", "journal": "Nutrients", "doi": "10.3390/nu18040694", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/41754211/", "doi_url": "https://doi.org/10.3390/nu18040694", "page_url": "https://h2medicine.org/studies/study-stolecka-warzecha-2026-redox-water-exercise-inflammation-oxidative-stress/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Sports / Performance; Oxidative stress; Immune system", "indication_keys": "sports-exercise; oxidative-stress; immune-system", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "41545661", "year": 2026, "title": "Exploratory Evaluation of Hydrogen-Rich Water Therapy for Keloid Management: A Double-Blinded Randomized Pilot Trial", "authors": "Kuang et al.", "journal": "Aesthetic Plastic Surgery", "doi": "10.1007/s00266-025-05512-5", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/41545661/", "doi_url": "https://doi.org/10.1007/s00266-025-05512-5", "page_url": "https://h2medicine.org/studies/study-kuang-2026-keloid-management-pilot-trial/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Skin / Aging; Oxidative stress; Immune system", "indication_keys": "skin-aging; oxidative-stress; immune-system", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "41859790", "year": 2026, "title": "The combined use of inhaled nitric oxide and molecular hydrogen in patients with post-COVID-19 syndrome", "authors": "Pozdnyakova et al.", "journal": "Terapevticheskii arkhiv", "doi": "10.26442/00403660.2026.03.203537", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/41859790/", "doi_url": "https://doi.org/10.26442/00403660.2026.03.203537", "page_url": "https://h2medicine.org/studies/study-pozdnyakova-2026-inhaled-nitric-oxide-post-covid-19-syndrome/", "methods": "Inhalation (H₂ gas); Bath / topical", "method_keys": "inhalation; bath-topical", "indications": "Respiratory / Lung; Oxidative stress; Immune system", "indication_keys": "respiratory; oxidative-stress; immune-system", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "42139605", "year": 2026, "title": "Hydration bioanalyses of the effects of hydrogen-rich water (HRW).", "authors": "Pesotskaya et al.", "journal": "Wiadomosci lekarskie (Warsaw, Poland : 1960)", "doi": "10.36740/wlek/218738", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/42139605/", "doi_url": "https://doi.org/10.36740/wlek/218738", "page_url": "https://h2medicine.org/studies/study-pesotskaya-2026-hydration-bioanalyses-hrw/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Kidney / Dialysis", "indication_keys": "kidney-dialysis", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "42049414", "year": 2026, "title": "Adjunctive Molecular Hydrogen Capsule Therapy in Empyema Complicated by Chronic Inflammatory Demyelinating Polyneuropathy: A Case Report.", "authors": "Li et al.", "journal": "In vivo (Athens, Greece)", "doi": "10.21873/invivo.14337", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/42049414/", "doi_url": "https://doi.org/10.21873/invivo.14337", "page_url": "https://h2medicine.org/studies/study-li-2026-adjunctive-capsule-empyema-complicated/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Neurology / Brain; Respiratory / Lung; Immune system; Oxidative stress", "indication_keys": "neurology; respiratory; immune-system; oxidative-stress", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "41906653", "year": 2026, "title": "Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via Promoting Mitophagy.", "authors": "Xu et al.", "journal": "Journal of diabetes", "doi": "10.1111/1753-0407.70209", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/41906653/", "doi_url": "https://doi.org/10.1111/1753-0407.70209", "page_url": "https://h2medicine.org/studies/study-xu-2026-enriched-hyaluronic-acid-dressing/", "methods": "Saline i.v.", "method_keys": "saline-iv", "indications": "Diabetes; Cardiovascular; Skin / Aging; Immune system; Oxidative stress", "indication_keys": "diabetes; cardiovascular; skin-aging; immune-system; oxidative-stress", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "41760342", "year": 2026, "title": "Adjunctive Molecular Hydrogen Therapy Modulates T Cell Markers and Reduces Anti-Ro Antibody in Refractory Oral Ulcers of Behçet's Disease and Sjögren's Syndrome: A Case Report.", "authors": "Lin et al.", "journal": "In vivo (Athens, Greece)", "doi": "10.21873/invivo.14274", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/41760342/", "doi_url": "https://doi.org/10.21873/invivo.14274", "page_url": "https://h2medicine.org/studies/study-lin-2026-adjunctive-modulates-cell-markers/", "methods": "Saline i.v.; Hydrogen-rich water (drinking)", "method_keys": "saline-iv; drinking-hrw", "indications": "Cardiovascular; Joints / Rheumatology; Immune system; Oxidative stress", "indication_keys": "cardiovascular; joints-rheumatology; immune-system; oxidative-stress", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "41582106", "year": 2026, "title": "Hydrogen inhalation is associated with a transient rightward shift in prefrontal oxyhemoglobin asymmetry and autonomic modulation.", "authors": "Moriya et al.", "journal": "Scientific reports", "doi": "10.1038/s41598-026-36599-8", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/41582106/", "doi_url": "https://doi.org/10.1038/s41598-026-36599-8", "page_url": "https://h2medicine.org/studies/study-moriya-2026-inhalation-associated-transient-rightward/", "methods": "Inhalation (H₂ gas); Bath / topical", "method_keys": "inhalation; bath-topical", "indications": "Liver; Neurology / Brain; Cardiovascular; Immune system; Oxidative stress", "indication_keys": "liver; neurology; cardiovascular; immune-system; oxidative-stress", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "41482402", "year": 2026, "title": "Rhupus Syndrome With Multiple Drug Intolerances Managed by Reduced-dose Rituximab and Adjunctive Molecular Hydrogen Therapy: A Case Report.", "authors": "Tsai et al.", "journal": "In vivo (Athens, Greece)", "doi": "10.21873/invivo.14221", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/41482402/", "doi_url": "https://doi.org/10.21873/invivo.14221", "page_url": "https://h2medicine.org/studies/study-tsai-2026-rhupus-syndrome-multiple-drug/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Cardiovascular; Joints / Rheumatology; Immune system; Oxidative stress", "indication_keys": "cardiovascular; joints-rheumatology; immune-system; oxidative-stress", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "41482388", "year": 2026, "title": "Adjuvant Molecular Hydrogen Therapy in SLE-associated Pulmonary Arterial Hypertension: A Case Report on Immunomodulatory Effects on Regulatory and Effector Lymphocytes.", "authors": "Liu et al.", "journal": "In vivo (Athens, Greece)", "doi": "10.21873/invivo.14220", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/41482388/", "doi_url": "https://doi.org/10.21873/invivo.14220", "page_url": "https://h2medicine.org/studies/study-liu-2026-adjuvant-sle-associated-pulmonary/", "methods": "Unspecified", "method_keys": "unspecified", "indications": "Neurology / Brain; Cardiovascular; Respiratory / Lung; Immune system; Oxidative stress", "indication_keys": "neurology; cardiovascular; respiratory; immune-system; oxidative-stress", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "42453934", "year": 2026, "title": "Preliminary Effects of Hydrogen-Oxygen Inhalation on Nodule Size, IL-6, and Neutrophils in Patients with Small Pulmonary Nodules.", "authors": "Wei et al.", "journal": "Drug design, development and therapy", "doi": "10.2147/DDDT.S605134", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/42453934/", "doi_url": "https://doi.org/10.2147/DDDT.S605134", "page_url": "https://h2medicine.org/studies/study-wei-2026-inhalation-small-pulmonary-nodules/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Respiratory / Lung; Immune system", "indication_keys": "respiratory; immune-system", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "42867080", "year": 2026, "title": "Hydrogen-rich jelly exhibits a positive effect on heart rate variability during orthostatic loading in healthy adults: a randomized crossover trial.", "authors": "Muramoto et al.", "journal": "Canadian journal of physiology and pharmacology", "doi": "10.1139/cjpp-2026-0062", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/42867080/", "doi_url": "https://doi.org/10.1139/cjpp-2026-0062", "page_url": "https://h2medicine.org/studies/study-muramoto-2026-jelly-heart-rate-variability/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Cardiovascular", "indication_keys": "cardiovascular", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "42338291", "year": 2026, "title": "Effects of Hydrogen Water Gargling on Oral Mucositis and Pain in Head and Neck Cancer Patients: A Randomized Controlled Pilot Study.", "authors": "Tsai et al.", "journal": "Integrative cancer therapies", "doi": "10.1177/15347354261463550", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/42338291/", "doi_url": "https://doi.org/10.1177/15347354261463550", "page_url": "https://h2medicine.org/studies/study-tsai-2026-gargling-oral-mucositis-pain/", "methods": "Bath / topical", "method_keys": "bath-topical", "indications": "Oral health; Cancer / Oncology", "indication_keys": "oral-health; cancer", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "42436242", "year": 2026, "title": "The impact of perioperative hydrogen gas inhalation on postoperative recovery in day surgery patients: a research study.", "authors": "Ji et al.", "journal": "Scientific reports", "doi": "10.1038/s41598-026-61287-y", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/42436242/", "doi_url": "https://doi.org/10.1038/s41598-026-61287-y", "page_url": "https://h2medicine.org/studies/study-ji-2026-perioperative-inhalation-postoperative-recovery/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Surgery & Anesthesia; Immune system", "indication_keys": "surgery-anesthesia; immune-system", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "42713248", "year": 2026, "title": "Effects of Hydrogen-Rich Water Supplementation on Exercise Performance, Autonomic Nervous System Recovery, and Blood Lactate Concentration During Repeated Sprint Exercise in Male University Athletes.", "authors": "Chen et al.", "journal": "Journal of sports science & medicine", "doi": "10.52082/jssm.2026.744", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/42713248/", "doi_url": "https://doi.org/10.52082/jssm.2026.744", "page_url": "https://h2medicine.org/studies/study-chen-2026-autonomic-lactate-repeated-sprint/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Sports / Performance", "indication_keys": "sports-exercise", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "42865187", "year": 2026, "title": "Post-Ingestion Blood Hydrogen Kinetics Following Oral Hydrogen-Rich Water Intake in Healthy Adults: A Pilot Pharmacokinetic Study.", "authors": "Nedeljkovic et al.", "journal": "Current reviews in clinical and experimental pharmacology", "doi": "10.2174/0127724328507426261006065812", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/42865187/", "doi_url": "https://doi.org/10.2174/0127724328507426261006065812", "page_url": "https://h2medicine.org/studies/study-nedeljkovic-2026-blood-kinetics-oral-water/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Fundamentals / Safety", "indication_keys": "fundamentals-safety", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "41371770", "year": 2026, "title": "Does Hydrogen-Rich Water Reduce Oxidative Stress in Patients with Chronic Mountain Sickness? A Randomized, Blinded, Controlled Trial.", "authors": "Zhang et al.", "journal": "High altitude medicine & biology", "doi": "10.1177/15578682251401137", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/41371770/", "doi_url": "https://doi.org/10.1177/15578682251401137", "page_url": "https://h2medicine.org/studies/study-zhang-2026-oxidative-stress-mountain-sickness/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Oxidative stress; Respiratory / Lung", "indication_keys": "oxidative-stress; respiratory", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "41908285", "year": 2026, "title": "A randomized controlled double-blind study on the brain protection of infantile patients with epileptic spasm syndrome through atomized inhalation of hydrogen-oxygen gas.", "authors": "Chen et al.", "journal": "Frontiers in neurology", "doi": "10.3389/fneur.2026.1781738", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/41908285/", "doi_url": "https://doi.org/10.3389/fneur.2026.1781738", "page_url": "https://h2medicine.org/studies/study-chen-2026-brain-protection-epileptic-spasm/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Neurology / Brain; Fundamentals / Safety", "indication_keys": "neurology; fundamentals-safety", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "40826930", "year": 2026, "title": "Effect of hydrogen-oxygen inhalation on sleep disorders and abnormal mood: a single-blind, randomized controlled trial.", "authors": "Gao et al.", "journal": "Medical gas research", "doi": "10.4103/mgr.MEDGASRES-D-25-00020", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/40826930/", "doi_url": "https://doi.org/10.4103/mgr.MEDGASRES-D-25-00020", "page_url": "https://h2medicine.org/studies/study-gao-2026-inhalation-sleep-disorders-mood/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Neurology / Brain", "indication_keys": "neurology", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "41991147", "year": 2026, "title": "Hydrogen-Rich Water as a Performance-Enhancing Aid in National-Level Finswimmers: A Randomized, Double-Blind, Placebo-Controlled Crossover Study.", "authors": "Sládečková et al.", "journal": "International journal of sports physiology and performance", "doi": "10.1123/ijspp.2025-0492", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/41991147/", "doi_url": "https://doi.org/10.1123/ijspp.2025-0492", "page_url": "https://h2medicine.org/studies/study-sladeckova-2026-performance-enhancing-aid-finswimmers/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Sports / Performance", "indication_keys": "sports-exercise", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "42512258", "year": 2026, "title": "Metabolomic Alterations Associated with Adjunctive Hydrogen Gas Inhalation During Concurrent Chemoradiotherapy in Locally Advanced Head and Neck Cancer: A Pilot Study.", "authors": "Chitapanarux et al.", "journal": "Cancers", "doi": "10.3390/cancers18142191", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/42512258/", "doi_url": "https://doi.org/10.3390/cancers18142191", "page_url": "https://h2medicine.org/studies/study-chitapanarux-2026-metabolomic-chemoradiotherapy-head-neck/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Cancer / Oncology", "indication_keys": "cancer", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "42796391", "year": 2026, "title": "Perioperative Hydrogen Inhalation and Postoperative Pain After Endoscopic Discectomy: A Pilot Non-Randomized Clinical Study with Exploratory Murine Data.", "authors": "Sung et al.", "journal": "Medicina (Kaunas, Lithuania)", "doi": "10.3390/medicina62091785", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/42796391/", "doi_url": "https://doi.org/10.3390/medicina62091785", "page_url": "https://h2medicine.org/studies/study-sung-2026-perioperative-inhalation-pain-discectomy/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Surgery & Anesthesia; Neurology / Brain", "indication_keys": "surgery-anesthesia; neurology", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "42232098", "year": 2026, "title": "Association of Self-Selected Hydrogen-Rich Water Consumption with 6-Month Changes in Chair-Stand Performance and Gait Speed among Community-Dwelling Older Adults Attending Community Salons.", "authors": "Harada et al.", "journal": "Journal of frailty, sarcopenia and falls", "doi": "10.22540/JFSF-11-137", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/42232098/", "doi_url": "https://doi.org/10.22540/JFSF-11-137", "page_url": "https://h2medicine.org/studies/study-harada-2026-chair-stand-gait-speed/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Sports / Performance", "indication_keys": "sports-exercise", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "39923133", "year": 2025, "title": "Molecular hydrogen inhalation modulates resting metabolism in healthy females: findings from a randomized, double-blind, placebo-controlled crossover study", "authors": "Grepl et al.", "journal": "Medical Gas Research", "doi": "10.4103/mgr.medgasres-d-24-00085", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/39923133/", "doi_url": "https://doi.org/10.4103/mgr.medgasres-d-24-00085", "page_url": "https://h2medicine.org/studies/study-grepl-2025-inhalation-resting-metabolism-healthy-females/", "methods": "Inhalation (H₂ gas); Bath / topical", "method_keys": "inhalation; bath-topical", "indications": "Metabolic; Oxidative stress", "indication_keys": "metabolic; oxidative-stress", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "40376695", "year": 2025, "title": "Hydrogen-Rich Water Decreases Muscle Damage and Improves Power Endurance in Elite Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial", "authors": "Ogannisyan et al.", "journal": "Journal of Lifestyle Medicine", "doi": "10.15280/jlm.2025.15.1.8", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/40376695/", "doi_url": "https://doi.org/10.15280/jlm.2025.15.1.8", "page_url": "https://h2medicine.org/studies/study-ogannisyan-2025-hydrogen-rich-water-muscle-damage-power-endurance-elite-athletes/", "methods": "Tablets / Magnesium; Hydrogen-rich water (drinking)", "method_keys": "tablets; drinking-hrw", "indications": "Sports / Performance; Oxidative stress", "indication_keys": "sports-exercise; oxidative-stress", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "40525414", "year": 2025, "title": "The effects of drinking hydrogen-rich water for six weeks on exercise-related biomarkers in exercise-naïve men and women over 50 years following resistance training program: a randomized controlled pilot trial", "authors": "Kuzmanovic et al.", "journal": "Research in Sports Medicine", "doi": "10.1080/15438627.2025.2521474", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/40525414/", "doi_url": "https://doi.org/10.1080/15438627.2025.2521474", "page_url": "https://h2medicine.org/studies/study-kuzmanovic-2025-drinking-hrw-exercise-biomarkers-over-50-resistance/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Sports / Performance; Metabolic; Oxidative stress", "indication_keys": "sports-exercise; metabolic; oxidative-stress", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "40731803", "year": 2025, "title": "Pre-Exercise Ingestion of Hydrogen-Rich Cold Water Enhances Endurance Performance and Lactate Response in Heat", "authors": "Khlifi et al.", "journal": "Medicina (Kaunas)", "doi": "10.3390/medicina61071173", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/40731803/", "doi_url": "https://doi.org/10.3390/medicina61071173", "page_url": "https://h2medicine.org/studies/study-khlifi-2025-pre-exercise-cold-water-endurance-heat/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Sports / Performance; Oxidative stress", "indication_keys": "sports-exercise; oxidative-stress", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "40731927", "year": 2025, "title": "The Effects of 8-Week Hydrogen-Rich Water Consumption on Appetite, Body Composition, Sleep Quality, and Circulating Glucagon-like Peptide-1 in Obese Men and Women (HYDRAPPET): A Randomized Controlled Trial", "authors": "Todorovic et al.", "journal": "Medicina (Kaunas)", "doi": "10.3390/medicina61071299", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/40731927/", "doi_url": "https://doi.org/10.3390/medicina61071299", "page_url": "https://h2medicine.org/studies/study-todorovic-2025-8-week-appetite-body-composition-sleep-glp-1-obese/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Metabolic; 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Sports / Performance; Kidney / Dialysis", "indication_keys": "metabolic; sports-exercise; kidney-dialysis", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "39804806", "year": 2025, "title": "Hydrogen-Rich Saline Combined With Vacuum Sealing Drainage Promotes Wound Healing by Altering Biotin Metabolism.", "authors": "Kuang et al.", "journal": "Journal of cellular and molecular medicine", "doi": "10.1111/jcmm.70292", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/39804806/", "doi_url": "https://doi.org/10.1111/jcmm.70292", "page_url": "https://h2medicine.org/studies/study-kuang-2025-saline-combined-vacuum-sealing/", "methods": "Saline i.v.", "method_keys": "saline-iv", "indications": "Skin / Aging; Immune system; Oxidative stress", "indication_keys": "skin-aging; immune-system; oxidative-stress", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "39740897", "year": 2025, "title": "Molecular Hydrogen as a Potential Adjunctive Therapy to Improve Renal Function and Reduce Fatigue in an Elderly Patient With Chronic Comorbidities: A Case Report.", "authors": "Lin et al.", "journal": "In vivo (Athens, Greece)", "doi": "10.21873/invivo.13862", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/39740897/", "doi_url": "https://doi.org/10.21873/invivo.13862", "page_url": "https://h2medicine.org/studies/study-lin-2025-adjunctive-improve-renal-function/", "methods": "Unspecified", "method_keys": "unspecified", "indications": "Diabetes; 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Immune system", "indication_keys": "cancer; immune-system", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "40077138", "year": 2025, "title": "Efficacy of Oral Intake of Hydrogen-Rich Jelly Intake on Gingival Inflammation: A Double-Blind, Placebo-Controlled and Exploratory Randomized Clinical Trial.", "authors": "Maruyama et al.", "journal": "Healthcare (Basel, Switzerland)", "doi": "10.3390/healthcare13050577", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/40077138/", "doi_url": "https://doi.org/10.3390/healthcare13050577", "page_url": "https://h2medicine.org/studies/study-maruyama-2025-oral-jelly-gingival-inflammation/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Oral health", "indication_keys": "oral-health", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "40563361", "year": 2025, "title": "Topically Applied Molecular Hydrogen Normalizes Skin Parameters Associated with Oxidative Stress: A Pilot Study.", "authors": "Debkowska et al.", "journal": "Antioxidants (Basel, Switzerland)", "doi": "10.3390/antiox14060729", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/40563361/", "doi_url": "https://doi.org/10.3390/antiox14060729", "page_url": "https://h2medicine.org/studies/study-debkowska-2025-topically-applied-skin-parameters/", "methods": "Bath / topical", "method_keys": "bath-topical", "indications": "Skin / Aging", "indication_keys": "skin-aging", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "41657606", "year": 2025, "title": "Hydrogen water versus normal saline for post-surgical irrigation: A study on healing and complication rates after third molar extraction.", "authors": "Devi et al.", "journal": "Bioinformation", "doi": "10.6026/973206300214148", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/41657606/", "doi_url": "https://doi.org/10.6026/973206300214148", "page_url": "https://h2medicine.org/studies/study-devi-2025-irrigation-third-molar-extraction/", "methods": "Bath / topical", "method_keys": "bath-topical", "indications": "Oral health; Surgery & Anesthesia", "indication_keys": "oral-health; surgery-anesthesia", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "39436179", "year": 2025, "title": "Fatigue disappearance in hemodialysis patients by dual approach with hydrogen gas inhalation and hydrogen-enriched dialysate: two case reports.", "authors": "Nakazawa et al.", "journal": "Medical gas research", "doi": "10.4103/mgr.MEDGASRES-D-24-00024", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/39436179/", "doi_url": "https://doi.org/10.4103/mgr.MEDGASRES-D-24-00024", "page_url": "https://h2medicine.org/studies/study-nakazawa-2025-fatigue-disappearance-hemodialysis-patients/", "methods": "Inhalation (H₂ gas); Saline i.v.", "method_keys": "inhalation; saline-iv", "indications": "Kidney / Dialysis", "indication_keys": "kidney-dialysis", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "40950921", "year": 2025, "title": "Alleviation of exercise-induced injury by hydrogen inhalation via the reduction of oxidative stress and inflammation in athletes.", "authors": "Zhang et al.", "journal": "Journal of thoracic disease", "doi": "10.21037/jtd-2025-1278", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/40950921/", "doi_url": "https://doi.org/10.21037/jtd-2025-1278", "page_url": "https://h2medicine.org/studies/study-zhang-2025-alleviation-exercise-injury-inhalation/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Sports / Performance; Oxidative stress; Respiratory / Lung", "indication_keys": "sports-exercise; oxidative-stress; respiratory", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "38532373", "year": 2024, "title": "The effect of hydrogen-rich water consumption on premenstrual symptoms and quality of life: a randomized controlled trial", "authors": "Aker et al.", "journal": "BMC Women's Health", "doi": "10.1186/s12905-024-03029-8", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/38532373/", "doi_url": "https://doi.org/10.1186/s12905-024-03029-8", "page_url": "https://h2medicine.org/studies/study-aker-2024-premenstrual-symptoms-quality-of-life/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Women's health; Oxidative stress", "indication_keys": "womens-health; oxidative-stress", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "38996821", "year": 2024, "title": "The impact of hydrogen inhalation therapy on blood reactive oxygen species levels: A randomized controlled study", "authors": "Chair et al.", "journal": "Free Radical Biology & Medicine", "doi": "10.1016/j.freeradbiomed.2024.07.010", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/38996821/", "doi_url": "https://doi.org/10.1016/j.freeradbiomed.2024.07.010", "page_url": "https://h2medicine.org/studies/study-chair-2024-inhalation-reactive-oxygen-species/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Oxidative stress; 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Medicine", "doi": "10.1016/j.xcrm.2023.101363", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/38232698/", "doi_url": "https://doi.org/10.1016/j.xcrm.2023.101363", "page_url": "https://h2medicine.org/studies/study-dawson-2024-early-time-restricted-eating/", "methods": "", "method_keys": "", "indications": "Diabetes; Cardiovascular", "indication_keys": "diabetes; cardiovascular", "evidence_level": 3, "therapeutic": 0, "h2category": "breath-test" }, { "pmid": "38713041", "year": 2024, "title": "[Rehabilitation program of post-COVID-19 syndrome with the use of nitric oxide and molecular hydrogen].", "authors": "Pozdnyakova et al.", "journal": "Terapevticheskii Arkhiv", "doi": "10.26442/00403660.2024.03.202639", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/38713041/", "doi_url": "https://doi.org/10.26442/00403660.2024.03.202639", "page_url": "https://h2medicine.org/studies/study-pozdnyakova-2024-nitric-oxide-post-covid-19-rehabilitation/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Respiratory / Lung; 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Bath / topical", "method_keys": "inhalation; bath-topical", "indications": "Respiratory / Lung; Immune system; Oxidative stress", "indication_keys": "respiratory; immune-system; oxidative-stress", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "39133068", "year": 2024, "title": "Combination of Hydrogen Inhalation and Hypothermic Temperature Control After Out-of-Hospital Cardiac Arrest: A Post hoc Analysis of the Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During PostCardiac Arrest Care II Trial", "authors": "Tamura et al.", "journal": "Critical Care Medicine", "doi": "10.1097/ccm.0000000000006395", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/39133068/", "doi_url": "https://doi.org/10.1097/ccm.0000000000006395", "page_url": "https://h2medicine.org/studies/study-tamura-2024-cardiac-arrest-hypothermic-neurologic-outcome/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Neurology / Brain; Cardiovascular", "indication_keys": "neurology; cardiovascular", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "39310256", "year": 2024, "title": "Using oral molecular hydrogen supplements to combat microinflammation in humans: a pilot observational study.", "authors": "Lu et al.", "journal": "International Journal of Medical Sciences", "doi": "10.7150/ijms.101114", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/39310256/", "doi_url": "https://doi.org/10.7150/ijms.101114", "page_url": "https://h2medicine.org/studies/study-lu-2024-oral-supplements-microinflammation/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Immune system; Oxidative stress; Metabolic", "indication_keys": "immune-system; oxidative-stress; metabolic", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "39477420", "year": 2024, "title": "Molecular Hydrogen Therapy in Aneurysmal SAH With RA and Newly-diagnosed SLE, Complicated With Acute Ischemic Infarction: A Case Report of Improved Immune Markers Including Tr1 Cells, Breg Cells and TIM3 Expression on Tc Cells.", "authors": "Chen et al.", "journal": "In vivo (Athens, Greece)", "doi": "10.21873/invivo.13799", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/39477420/", "doi_url": "https://doi.org/10.21873/invivo.13799", "page_url": "https://h2medicine.org/studies/study-chen-2024-aneurysmal-sah-newly-diagnosed/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Neurology / Brain; 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Hydrogen-rich water (drinking)", "method_keys": "inhalation; drinking-hrw", "indications": "Neurology / Brain", "indication_keys": "neurology", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "36969346", "year": 2023, "title": "Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac arrest care (HYBRID II): a multi-centre, randomised, double-blind, placebo-controlled trial.", "authors": "Tamura et al.", "journal": "EClinicalMedicine", "doi": "10.1016/j.eclinm.2023.101907", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/36969346/", "doi_url": "https://doi.org/10.1016/j.eclinm.2023.101907", "page_url": "https://h2medicine.org/studies/study-tamura-2023-hybrid-ii-inhaled-hydrogen-cardiac-arrest/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Neurology / Brain; Cardiovascular", "indication_keys": "neurology; cardiovascular", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "38107500", "year": 2023, "title": "Efficacy and Safety of Hydrogen Therapy in Patients with Early-Stage Interstitial Lung Disease: A Single-Center, Randomized, Parallel-Group Controlled Trial.", "authors": "Tang et al.", "journal": "Therapeutics and clinical risk management", "doi": "10.2147/TCRM.S438044", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/38107500/", "doi_url": "https://doi.org/10.2147/TCRM.S438044", "page_url": "https://h2medicine.org/studies/study-tang-2023-early-stage-interstitial-lung-disease/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Respiratory / Lung", "indication_keys": "respiratory", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "37970554", "year": 2023, "title": "The efficacy of hydrogen/oxygen therapy favored the recovery of omicron SARS-CoV-2 variant infection: results of a multicenter, randomized, controlled trial.", "authors": "Shi et al.", "journal": "Journal of clinical biochemistry and nutrition", "doi": "10.3164/jcbn.23-32", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/37970554/", "doi_url": "https://doi.org/10.3164/jcbn.23-32", "page_url": "https://h2medicine.org/studies/study-shi-2023-oxygen-therapy-recovery-omicron/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Respiratory / Lung", "indication_keys": "respiratory", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "37371975", "year": 2023, "title": "Hydrogen-Rich Water Ameliorates Metabolic Disorder via Modifying Gut Microbiota in Impaired Fasting Glucose Patients: A Randomized Controlled Study.", "authors": "Liang et al.", "journal": "Antioxidants (Basel, Switzerland)", "doi": "10.3390/antiox12061245", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/37371975/", "doi_url": "https://doi.org/10.3390/antiox12061245", "page_url": "https://h2medicine.org/studies/study-liang-2023-metabolic-disorder-gut-microbiota/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Metabolic; Diabetes", "indication_keys": "metabolic; diabetes", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "38162831", "year": 2023, "title": "Acute effect of hydrogen-rich water on physical, perceptual and cardiac responses during aerobic and anaerobic exercises: a randomized, placebo-controlled, double-blinded cross-over trial.", "authors": "Jebabli et al.", "journal": "Frontiers in physiology", "doi": "10.3389/fphys.2023.1240871", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/38162831/", "doi_url": "https://doi.org/10.3389/fphys.2023.1240871", "page_url": "https://h2medicine.org/studies/study-jebabli-2023-acute-aerobic-anaerobic-exercises/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Sports / Performance", "indication_keys": "sports-exercise", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "37386364", "year": 2023, "title": "Effect of hydrogen/oxygen therapy for ordinary COVID-19 patients: a propensity-score matched case-control study.", "authors": "Zeng et al.", "journal": "BMC infectious diseases", "doi": "10.1186/s12879-023-08424-4", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/37386364/", "doi_url": "https://doi.org/10.1186/s12879-023-08424-4", "page_url": "https://h2medicine.org/studies/study-zeng-2023-oxygen-therapy-ordinary-covid/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Respiratory / Lung", "indication_keys": "respiratory", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "37873771", "year": 2023, "title": "Can Hydrogen Water Enhance Oxygen Saturation in Patients with Chronic Lung Disease? A Non-Randomized, Observational Pilot Study.", "authors": "Singh et al.", "journal": "Diseases (Basel, Switzerland)", "doi": "10.3390/diseases11040127", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/37873771/", "doi_url": "https://doi.org/10.3390/diseases11040127", "page_url": "https://h2medicine.org/studies/study-singh-2023-oxygen-saturation-chronic-lung/", "methods": "Hydrogen-rich water (drinking); Tablets / Magnesium", "method_keys": "drinking-hrw; tablets", "indications": "Respiratory / Lung; Oxidative stress", "indication_keys": "respiratory; oxidative-stress", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "37860576", "year": 2023, "title": "The clinical research on the effect of hydrogen-rich water on primary retinitis pigmentosa.", "authors": "Chen et al.", "journal": "Heliyon", "doi": "10.1016/j.heliyon.2023.e20671", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/37860576/", "doi_url": "https://doi.org/10.1016/j.heliyon.2023.e20671", "page_url": "https://h2medicine.org/studies/study-chen-2023-water-primary-retinitis-pigmentosa/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Eye", "indication_keys": "eye", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "37431394", "year": 2023, "title": "Real-World Effectiveness and Safety of Hydrogen Inhalation in Chinese Patients with Type 2 Diabetes: A Single-Arm, Retrospective Study.", "authors": "Ji et al.", "journal": "Diabetes, metabolic syndrome and obesity : targets and therapy", "doi": "10.2147/DMSO.S412898", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/37431394/", "doi_url": "https://doi.org/10.2147/DMSO.S412898", "page_url": "https://h2medicine.org/studies/study-ji-2023-inhalation-chinese-type-2-diabetes/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Diabetes; Metabolic", "indication_keys": "diabetes; metabolic", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "37371971", "year": 2023, "title": "Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial.", "authors": "Rahman et al.", "journal": "Antioxidants (Basel, Switzerland)", "doi": "10.3390/antiox12061241", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/37371971/", "doi_url": "https://doi.org/10.3390/antiox12061241", "page_url": "https://h2medicine.org/studies/study-rahman-2023-gas-inhalation-community-dwelling-adults/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Neurology / Brain; Oxidative stress; Fundamentals / Safety", "indication_keys": "neurology; oxidative-stress; fundamentals-safety", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "36986533", "year": 2023, "title": "Therapeutic Inhalation of Hydrogen Gas for Alzheimer's Disease Patients and Subsequent Long-Term Follow-Up as a Disease-Modifying Treatment: An Open Label Pilot Study.", "authors": "Ono et al.", "journal": "Pharmaceuticals (Basel, Switzerland)", "doi": "10.3390/ph16030434", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/36986533/", "doi_url": "https://doi.org/10.3390/ph16030434", "page_url": "https://h2medicine.org/studies/study-ono-2023-therapeutic-inhalation-alzheimers-patients/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Neurology / Brain", "indication_keys": "neurology", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "37505148", "year": 2023, "title": "Efficacy of donepezil plus hydrogen-oxygen mixture inhalation for treatment of patients with Alzheimer disease: A retrospective study.", "authors": "Dan et al.", "journal": "Medicine", "doi": "10.1097/MD.0000000000034382", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/37505148/", "doi_url": "https://doi.org/10.1097/MD.0000000000034382", "page_url": "https://h2medicine.org/studies/study-dan-2023-donepezil-oxygen-inhalation-alzheimer/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Neurology / Brain", "indication_keys": "neurology", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "33555824", "year": 2022, "title": "Hydrogen Rich Water Consumption Positively Affects Muscle Performance, Lactate Response, and Alleviates Delayed Onset of Muscle Soreness After Resistance Training", "authors": "Botek et al.", "journal": "Journal of Strength and Conditioning Research", "doi": "10.1519/jsc.0000000000003979", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/33555824/", "doi_url": "https://doi.org/10.1519/jsc.0000000000003979", "page_url": "https://h2medicine.org/studies/study-botek-2022-muscle-performance-delayed-onset-soreness-resistance-training/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Sports / Performance; Oxidative stress", "indication_keys": "sports-exercise; oxidative-stress", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "35206179", "year": 2022, "title": "Molecular Hydrogen Positively Affects Physical and Respiratory Function in Acute Post-COVID-19 Patients: A New Perspective in Rehabilitation", "authors": "Botek et al.", "journal": "International Journal of Environmental Research and Public Health", "doi": "10.3390/ijerph19041992", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/35206179/", "doi_url": "https://doi.org/10.3390/ijerph19041992", "page_url": "https://h2medicine.org/studies/study-botek-2022-post-covid-19-respiratory-rehabilitation/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Respiratory / Lung; Immune system; Oxidative stress; Sports / Performance", "indication_keys": "respiratory; immune-system; oxidative-stress; sports-exercise", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "35276867", "year": 2022, "title": "Molecular Hydrogen Mitigates Performance Decrement during Repeated Sprints in Professional Soccer Players", "authors": "Botek et al.", "journal": "Nutrients", "doi": "10.3390/nu14030508", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/35276867/", "doi_url": "https://doi.org/10.3390/nu14030508", "page_url": "https://h2medicine.org/studies/study-botek-2022-repeated-sprints-soccer-players/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Sports / Performance; Oxidative stress", "indication_keys": "sports-exercise; oxidative-stress", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "35734974", "year": 2022, "title": "A randomized, placebo-controlled clinical trial of hydrogen/oxygen inhalation for non-alcoholic fatty liver disease", "authors": "Tao et al.", "journal": "Journal of Cellular and Molecular Medicine", "doi": "10.1111/jcmm.17456", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/35734974/", "doi_url": "https://doi.org/10.1111/jcmm.17456", "page_url": "https://h2medicine.org/studies/study-tao-2022-oxygen-inhalation-nonalcoholic-fatty-liver/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Liver; Metabolic; Oxidative stress", "indication_keys": "liver; metabolic; oxidative-stress", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "36538554", "year": 2022, "title": "Acute pre-exercise hydrogen rich water intake does not improve running performance at maximal aerobic speed in trained track and field runners: A randomized, double-blind, placebo-controlled crossover study", "authors": "Valenta et al.", "journal": "PLoS ONE", "doi": "10.1371/journal.pone.0279307", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/36538554/", "doi_url": "https://doi.org/10.1371/journal.pone.0279307", "page_url": "https://h2medicine.org/studies/study-valenta-2022-pre-exercise-maximal-aerobic-speed-runners/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Sports / Performance", "indication_keys": "sports-exercise", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "36235628", "year": 2022, "title": "The Acute Effects of a Single Dose of Molecular Hydrogen Supplements on Responses to Ergogenic Adjustments during High-Intensity Intermittent Exercise in Humans", "authors": "Alharbi et al.", "journal": "Nutrients", "doi": "10.3390/nu14193974", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/36235628/", "doi_url": "https://doi.org/10.3390/nu14193974", "page_url": "https://h2medicine.org/studies/study-alharbi-2022-single-dose-ergogenic-intermittent-exercise/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Sports / Performance; Oxidative stress", "indication_keys": "sports-exercise; oxidative-stress", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "36432562", "year": 2022, "title": "Effects of Intestinal Bacterial Hydrogen Gas Production on Muscle Recovery following Intense Exercise in Adult Men: A Pilot Study", "authors": "Eda et al.", "journal": "Nutrients", "doi": "10.3390/nu14224875", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/36432562/", "doi_url": "https://doi.org/10.3390/nu14224875", "page_url": "https://h2medicine.org/studies/study-eda-2022-intestinal-bacterial-gas-muscle-recovery/", "methods": "", "method_keys": "", "indications": "Sports / Performance; Oxidative stress", "indication_keys": "sports-exercise; oxidative-stress", "evidence_level": 3, "therapeutic": 0, "h2category": "byproduct" }, { "pmid": "36743938", "year": 2022, "title": "Effectiveness and safety of hydrogen inhalation as an adjunct treatment in Chinese type 2 diabetes patients: A retrospective, observational, double-arm, real-life clinical study.", "authors": "Zhao et al.", "journal": "Frontiers in Endocrinology", "doi": "10.3389/fendo.2022.1114221", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/36743938/", "doi_url": "https://doi.org/10.3389/fendo.2022.1114221", "page_url": "https://h2medicine.org/studies/study-zhao-2022-inhalation-type-2-diabetes-adjunct/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Diabetes; Metabolic; Oxidative stress", "indication_keys": "diabetes; metabolic; oxidative-stress", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "36210415", "year": 2022, "title": "Dynamics of Metabolic and Oxidative Parameters of Erythrocytes during Treatment of Chronic Heart Failure with Molecular Hydrogen.", "authors": "Deryugina et al.", "journal": "Bulletin of experimental biology and medicine", "doi": "10.1007/s10517-022-05595-z", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/36210415/", "doi_url": "https://doi.org/10.1007/s10517-022-05595-z", "page_url": "https://h2medicine.org/studies/study-deryugina-2022-dynamics-metabolic-oxidative-parameters/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Cardiovascular; Oxidative stress", "indication_keys": "cardiovascular; oxidative-stress", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "35843727", "year": 2022, "title": "A potential clinical application of hydrogen-rich saline in patients with traumatic brain injury.", "authors": "Benjamin et al.", "journal": "Journal of pediatric surgery", "doi": "10.1016/j.jpedsurg.2022.06.007", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/35843727/", "doi_url": "https://doi.org/10.1016/j.jpedsurg.2022.06.007", "page_url": "https://h2medicine.org/studies/study-benjamin-2022-application-saline-traumatic-brain/", "methods": "Saline i.v.", "method_keys": "saline-iv", "indications": "Neurology / Brain", "indication_keys": "neurology", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "35606529", "year": 2022, "title": "Radiographic features of magnesium-based bioabsorbable screw resorption in paediatric fractures.", "authors": "Waelti et al.", "journal": "Pediatric radiology", "doi": "10.1007/s00247-022-05383-x", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/35606529/", "doi_url": "https://doi.org/10.1007/s00247-022-05383-x", "page_url": "https://h2medicine.org/studies/study-waelti-2022-radiographic-features-magnesium-bioabsorbable/", "methods": "", "method_keys": "", "indications": "Joints / Rheumatology", "indication_keys": "joints-rheumatology", "evidence_level": 2, "therapeutic": 0, "h2category": "byproduct" }, { "pmid": "35564808", "year": 2022, "title": "Short-Term Consumption of Hydrogen-Rich Water Enhances Power Performance and Heart Rate Recovery in Dragon Boat Athletes: Evidence from a Pilot Study.", "authors": "Dong et al.", "journal": "International journal of environmental research and public health", "doi": "10.3390/ijerph19095413", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/35564808/", "doi_url": "https://doi.org/10.3390/ijerph19095413", "page_url": "https://h2medicine.org/studies/study-dong-2022-short-term-consumption-enhances/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Sports / Performance; Cardiovascular; Oxidative stress", "indication_keys": "sports-exercise; cardiovascular; oxidative-stress", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "34854419", "year": 2022, "title": "Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity based on oxygen radical absorbing and inflammation levels in human serum.", "authors": "Tanaka et al.", "journal": "Medical gas research", "doi": "10.4103/2045-9912.330692", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/34854419/", "doi_url": "https://doi.org/10.4103/2045-9912.330692", "page_url": "https://h2medicine.org/studies/study-tanaka-2022-bath-nano-sized-bubbles/", "methods": "Bath / topical", "method_keys": "bath-topical", "indications": "Skin / Aging; Immune system; Oxidative stress; Fundamentals / Safety", "indication_keys": "skin-aging; immune-system; oxidative-stress; fundamentals-safety", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "36115583", "year": 2022, "title": "Molecular hydrogen has a positive impact on pregnancy maintenance through enhancement of mitochondrial function and immunomodulatory effects on T cells", "authors": "Aoki et al.", "journal": "Life Sciences", "doi": "10.1016/j.lfs.2022.120955", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/36115583/", "doi_url": "https://doi.org/10.1016/j.lfs.2022.120955", "page_url": "https://h2medicine.org/studies/study-aoki-2022-pregnancy-maintenance-mitochondrial-t-cells/", "methods": "", "method_keys": "", "indications": "Pregnancy; Women's health; Immune system; Mechanism of action", "indication_keys": "pregnancy; womens-health; immune-system; mechanism", "evidence_level": 2, "therapeutic": 0, "h2category": "breath-test" }, { "pmid": "35873384", "year": 2022, "title": "The Beneficial Effects of Hydrogen-Rich Saline Irrigation on Chronic Rhinitis: A Randomized, Double-Blind Clinical Trial.", "authors": "Jin et al.", "journal": "Journal of inflammation research", "doi": "10.2147/JIR.S365611", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/35873384/", "doi_url": "https://doi.org/10.2147/JIR.S365611", "page_url": "https://h2medicine.org/studies/study-jin-2022-saline-irrigation-chronic-rhinitis/", "methods": "Bath / topical", "method_keys": "bath-topical", "indications": "Respiratory / Lung; Allergy", "indication_keys": "respiratory; allergy", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "35059257", "year": 2022, "title": "Electrolyzed hydrogen-rich water for oxidative stress suppression and improvement of insulin resistance: a multicenter prospective double-blind randomized control trial.", "authors": "Ogawa et al.", "journal": "Diabetology international", "doi": "10.1007/s13340-021-00524-3", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/35059257/", "doi_url": "https://doi.org/10.1007/s13340-021-00524-3", "page_url": "https://h2medicine.org/studies/study-ogawa-2022-electrolyzed-water-insulin-resistance/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Diabetes; Metabolic", "indication_keys": "diabetes; metabolic", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "36278221", "year": 2022, "title": "The effect of a low dose hydrogen-oxygen mixture inhalation in midlife/older adults with hypertension: A randomized, placebo-controlled trial.", "authors": "Liu et al.", "journal": "Frontiers in pharmacology", "doi": "10.3389/fphar.2022.1025487", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/36278221/", "doi_url": "https://doi.org/10.3389/fphar.2022.1025487", "page_url": "https://h2medicine.org/studies/study-liu-2022-low-dose-inhalation-hypertension/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Cardiovascular", "indication_keys": "cardiovascular", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "36290657", "year": 2022, "title": "Biological Effects of Hydrogen Water on Subjects with NAFLD: A Randomized, Placebo-Controlled Trial.", "authors": "Kura et al.", "journal": "Antioxidants (Basel, Switzerland)", "doi": "10.3390/antiox11101935", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/36290657/", "doi_url": "https://doi.org/10.3390/antiox11101935", "page_url": "https://h2medicine.org/studies/study-kura-2022-biological-water-nafld-randomized/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Liver; Metabolic", "indication_keys": "liver; metabolic", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "36507329", "year": 2022, "title": "A double-blinded, randomized controlled clinical trial of hydrogen inhalation therapy for idiopathic sudden sensorineural hearing loss.", "authors": "Okada et al.", "journal": "Frontiers in neuroscience", "doi": "10.3389/fnins.2022.1024634", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/36507329/", "doi_url": "https://doi.org/10.3389/fnins.2022.1024634", "page_url": "https://h2medicine.org/studies/study-okada-2022-inhalation-sudden-sensorineural-hearing/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Hearing", "indication_keys": "hearing", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "35774917", "year": 2022, "title": "Effects of hydrogen water and psychological treatment in a sample of women with panic disorder: a randomized and controlled clinical trial.", "authors": "Fernández-Serrano et al.", "journal": "Health psychology research", "doi": "10.52965/001c.35468", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/35774917/", "doi_url": "https://doi.org/10.52965/001c.35468", "page_url": "https://h2medicine.org/studies/study-fernandez-serrano-2022-psychological-treatment-panic-disorder/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Neurology / Brain; 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The japanese journal of urology", "doi": "10.5980/jpnjurol.112.11", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/35046230/", "doi_url": "https://doi.org/10.5980/jpnjurol.112.11", "page_url": "https://h2medicine.org/studies/study-sugaya-2021-association-breath-concentration-oral/", "methods": "", "method_keys": "", "indications": "Skin / Aging; Fundamentals / Safety", "indication_keys": "skin-aging; fundamentals-safety", "evidence_level": 2, "therapeutic": 0, "h2category": "breath-test" }, { "pmid": "34674744", "year": 2021, "title": "Effect of hydrogen gas inhalation on patient QOL after hepatectomy: protocol for a randomized controlled trial.", "authors": "Kaibori et al.", "journal": "Trials", "doi": "10.1186/s13063-021-05697-5", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/34674744/", "doi_url": "https://doi.org/10.1186/s13063-021-05697-5", "page_url": "https://h2medicine.org/studies/study-kaibori-2021-inhalation-qol-after-hepatectomy/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Surgery & Anesthesia; Liver; Immune system; Oxidative stress", "indication_keys": "surgery-anesthesia; liver; immune-system; oxidative-stress", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "34513069", "year": 2021, "title": "Application of Molecular Hydrogen in Heart Surgery under Cardiopulmonary Bypass.", "authors": "Danilova et al.", "journal": "Sovremennye tekhnologii v meditsine", "doi": "10.17691/stm2021.13.1.09", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/34513069/", "doi_url": "https://doi.org/10.17691/stm2021.13.1.09", "page_url": "https://h2medicine.org/studies/study-danilova-2021-application-heart-surgery-under/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Surgery & Anesthesia; Metabolic; Cardiovascular; Respiratory / Lung; Oxidative stress", "indication_keys": "surgery-anesthesia; metabolic; cardiovascular; respiratory; oxidative-stress", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "33899541", "year": 2021, "title": "Effects of hydrogen as adjuvant treatment for unstable angina.", "authors": "Si et al.", "journal": "Experimental biology and medicine (Maywood, N.J.)", "doi": "10.1177/15353702211009138", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/33899541/", "doi_url": "https://doi.org/10.1177/15353702211009138", "page_url": "https://h2medicine.org/studies/study-si-2021-adjuvant-unstable-angina/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Metabolic; Cardiovascular; Immune system; Oxidative stress", "indication_keys": "metabolic; cardiovascular; immune-system; oxidative-stress", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "33642332", "year": 2021, "title": "High-flow hydrogen inhalation might suppresses the immune function of middle-aged participants: a self-controlled study.", "authors": "Chen et al.", "journal": "Medical gas research", "doi": "10.4103/2045-9912.310054", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/33642332/", "doi_url": "https://doi.org/10.4103/2045-9912.310054", "page_url": "https://h2medicine.org/studies/study-chen-2021-high-flow-inhalation-might/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Cancer / Oncology; Immune system", "indication_keys": "cancer; immune-system", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "33475845", "year": 2021, "title": "The prevalence of intestinal dysbiosis in patients referred for antireflux surgery.", "authors": "Haworth et al.", "journal": "Surgical endoscopy", "doi": "10.1007/s00464-020-08229-5", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/33475845/", "doi_url": "https://doi.org/10.1007/s00464-020-08229-5", "page_url": "https://h2medicine.org/studies/study-haworth-2021-prevalence-intestinal-dysbiosis-referred/", "methods": "", "method_keys": "", "indications": "Other", "indication_keys": "other", "evidence_level": 2, "therapeutic": 0, "h2category": "breath-test" }, { "pmid": "33985501", "year": 2021, "title": "Hydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary disease: results of a multicenter, randomized, double-blind, parallel-group controlled trial.", "authors": "Zheng et al.", "journal": "Respiratory research", "doi": "10.1186/s12931-021-01740-w", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/33985501/", "doi_url": "https://doi.org/10.1186/s12931-021-01740-w", "page_url": "https://h2medicine.org/studies/study-zheng-2021-oxygen-therapy-acute-exacerbation/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Respiratory / Lung", "indication_keys": "respiratory", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "34651133", "year": 2021, "title": "Safety of Prolonged Inhalation of Hydrogen Gas in Air in Healthy Adults.", "authors": "Cole et al.", "journal": "Critical care explorations", "doi": "10.1097/CCE.0000000000000543", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/34651133/", "doi_url": "https://doi.org/10.1097/CCE.0000000000000543", "page_url": "https://h2medicine.org/studies/study-cole-2021-prolonged-inhalation-healthy-adults/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Fundamentals / Safety", "indication_keys": "fundamentals-safety", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "34532023", "year": 2021, "title": "Hydrogen-rich water and caffeine for alertness and brain metabolism in sleep-deprived habitual coffee drinkers.", "authors": "Todorovic et al.", "journal": "Food science & nutrition", "doi": "10.1002/fsn3.2480", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/34532023/", "doi_url": "https://doi.org/10.1002/fsn3.2480", "page_url": "https://h2medicine.org/studies/study-todorovic-2021-caffeine-alertness-brain-metabolism/", "methods": 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"https://doi.org/10.1371/journal.pone.0233484", "page_url": "https://h2medicine.org/studies/study-ishibashi-2020-peripheral-endothelial-function-7ppm/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Cardiovascular; Oxidative stress", "indication_keys": "cardiovascular; oxidative-stress", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "32699287", "year": 2020, "title": "Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial", "authors": "Sim et al.", "journal": "Scientific Reports", "doi": "10.1038/s41598-020-68930-2", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/32699287/", "doi_url": "https://doi.org/10.1038/s41598-020-68930-2", "page_url": "https://h2medicine.org/studies/study-sim-2020-inflammatory-responses-apoptosis-blood-cells/", "methods": "Hydrogen-rich water (drinking)", "method_keys": 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nasal cavity].", "authors": "Jin et al.", "journal": "Lin chuang er bi yan hou tou jing wai ke za zhi (Journal of Clinical Otorhinolaryngology Head and Neck Surgery)", "doi": null, "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/32791592/", "doi_url": null, "page_url": "https://h2medicine.org/studies/study-jin-2020-allergic-rhinitis-nasal-saline-lavage/", "methods": "Saline i.v.; Bath / topical", "method_keys": "saline-iv; bath-topical", "indications": "Allergy; Respiratory / Lung", "indication_keys": "allergy; respiratory", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "33324415", "year": 2020, "title": "Hydrogen in Patients With Corticosteroid-Refractory/Dependent Chronic Graft-Versus-Host-Disease: A Single-Arm, Multicenter, Open-Label, Phase 2 Trial", "authors": "Qian et al.", "journal": "Frontiers in Immunology", "doi": "10.3389/fimmu.2020.598359", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/33324415/", "doi_url": "https://doi.org/10.3389/fimmu.2020.598359", "page_url": "https://h2medicine.org/studies/study-qian-2020-chronic-graft-versus-host-disease-phase-2-trial/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Immune system; Oxidative stress", "indication_keys": "immune-system; oxidative-stress", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "33380580", "year": 2020, "title": "Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system senescence patients with advanced non-small cell lung cancer: a self-controlled study", "authors": "Chen et al.", "journal": "Medical Gas Research", "doi": "10.4103/2045-9912.304221", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/33380580/", "doi_url": "https://doi.org/10.4103/2045-9912.304221", "page_url": "https://h2medicine.org/studies/study-chen-2020-inhalation-immune-senescence-lung-cancer/", "methods": "Inhalation (H₂ gas)", "method_keys": 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advanced non-small cell lung cancer.", "authors": "Chen et al.", "journal": "Medical gas research", "doi": "10.4103/2045-9912.285560", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/32541132/", "doi_url": "https://doi.org/10.4103/2045-9912.285560", "page_url": "https://h2medicine.org/studies/study-chen-2020-can-used-control-tumor/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Cancer / Oncology; Respiratory / Lung", "indication_keys": "cancer; respiratory", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "32407476", "year": 2020, "title": "Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients.", "authors": "Wang et al.", "journal": "QJM : monthly journal of the Association of Physicians", "doi": "10.1093/qjmed/hcaa164", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/32407476/", "doi_url": "https://doi.org/10.1093/qjmed/hcaa164", "page_url": 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"indication_keys": "sports-exercise; immune-system", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "32189665", "year": 2020, "title": "Hydrogen-rich water suppresses the reduction in blood total antioxidant capacity induced by 3 consecutive days of severe exercise in physically active males.", "authors": "Dobashi et al.", "journal": "Medical gas research", "doi": "10.4103/2045-9912.279979", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/32189665/", "doi_url": "https://doi.org/10.4103/2045-9912.279979", "page_url": "https://h2medicine.org/studies/study-dobashi-2020-suppresses-reduction-blood-total/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Sports / Performance; Immune system; Oxidative stress", "indication_keys": "sports-exercise; immune-system; oxidative-stress", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "32273740", "year": 2020, "title": "The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial.", "authors": "LeBaron et al.", "journal": "Diabetes, metabolic syndrome and obesity : targets and therapy", "doi": "10.2147/DMSO.S240122", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/32273740/", "doi_url": "https://doi.org/10.2147/DMSO.S240122", "page_url": "https://h2medicine.org/studies/study-lebaron-2020-high-concentration-metabolic-syndrome/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Metabolic; Cardiovascular", "indication_keys": "metabolic; cardiovascular", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "32642277", "year": 2020, "title": "Hydrogen/oxygen mixed gas inhalation improves disease severity and dyspnea in patients with Coronavirus disease 2019 in a recent multicenter, open-label clinical trial.", "authors": "Guan et al.", "journal": "Journal of thoracic disease", "doi": "10.21037/jtd-2020-057", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/32642277/", "doi_url": "https://doi.org/10.21037/jtd-2020-057", "page_url": "https://h2medicine.org/studies/study-guan-2020-oxygen-inhalation-dyspnea-coronavirus/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Respiratory / Lung", "indication_keys": "respiratory", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "32045879", "year": 2020, "title": "Hydrogen-Rich Water Supplementation and Up-Hill Running Performance: Effect of Athlete Performance Level.", "authors": "Botek et al.", "journal": "International journal of sports physiology and performance", "doi": "10.1123/ijspp.2019-0507", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/32045879/", "doi_url": "https://doi.org/10.1123/ijspp.2019-0507", "page_url": 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"evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "33123594", "year": 2020, "title": "The Effects of Supersaturated Hydrogen-Rich Water Bathing on Biomarkers of Muscular Damage and Soreness Perception in Young Men Subjected to High-Intensity Eccentric Exercise.", "authors": "Todorovic et al.", "journal": "Journal of sports medicine (Hindawi Publishing Corporation)", "doi": "10.1155/2020/8836070", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/33123594/", "doi_url": "https://doi.org/10.1155/2020/8836070", "page_url": "https://h2medicine.org/studies/study-todorovic-2020-supersaturated-bathing-muscular-damage/", "methods": "Bath / topical", "method_keys": "bath-topical", "indications": "Sports / Performance", "indication_keys": "sports-exercise", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "31251888", "year": 2019, "title": "Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study", "authors": "Mikami et al.", "journal": "Canadian Journal of Physiology and Pharmacology", "doi": "10.1139/cjpp-2019-0059", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/31251888/", "doi_url": "https://doi.org/10.1139/cjpp-2019-0059", "page_url": "https://h2medicine.org/studies/study-mikami-2019-endurance-psychometric-fatigue/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Sports / Performance; Oxidative stress", "indication_keys": "sports-exercise; oxidative-stress", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "31574544", "year": 2019, "title": "Hydrogen Rich Water Improved Ventilatory, Perceptual and Lactate Responses to Exercise", "authors": "Botek et al.", "journal": "International Journal of Sports Medicine", "doi": "10.1055/a-0991-0268", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/31574544/", "doi_url": "https://doi.org/10.1055/a-0991-0268", "page_url": "https://h2medicine.org/studies/study-botek-2019-ventilatory-lactate-responses-exercise/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Sports / Performance", "indication_keys": "sports-exercise", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "30982748", "year": 2019, "title": "Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial.", "authors": "Korovljev et al.", "journal": "Clinics and research in hepatology and gastroenterology", "doi": "10.1016/j.clinre.2019.03.008", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/30982748/", "doi_url": "https://doi.org/10.1016/j.clinre.2019.03.008", "page_url": "https://h2medicine.org/studies/study-korovljev-2019-reduces-liver-fat-accumulation/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Metabolic; Liver; 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"journal": "F1000Research", "doi": "10.12688/f1000research.19739.1", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/32595937/", "doi_url": "https://doi.org/10.12688/f1000research.19739.1", "page_url": "https://h2medicine.org/studies/study-javorac-2019-buccal-administration-producing-blend/", "methods": "Tablets / Magnesium; Hydrogen-rich water (drinking)", "method_keys": "tablets; drinking-hrw", "indications": "Sports / Performance; Neurology / Brain; Fundamentals / Safety", "indication_keys": "sports-exercise; neurology; fundamentals-safety", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "31552873", "year": 2019, "title": "\"Real world survey\" of hydrogen-controlled cancer: a follow-up report of 82 advanced cancer patients.", "authors": "Chen et al.", "journal": "Medical gas research", "doi": "10.4103/2045-9912.266985", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/31552873/", "doi_url": "https://doi.org/10.4103/2045-9912.266985", "page_url": 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"methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Skin / Aging; Immune system", "indication_keys": "skin-aging; immune-system", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "31249254", "year": 2019, "title": "Effects of hydrogen-rich water bath on visceral fat and skin blotch, with boiling-resistant hydrogen bubbles.", "authors": "Asada et al.", "journal": "Medical gas research", "doi": "10.4103/2045-9912.260647", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/31249254/", "doi_url": "https://doi.org/10.4103/2045-9912.260647", "page_url": "https://h2medicine.org/studies/study-asada-2019-bath-visceral-fat-skin/", "methods": "Bath / topical; Hydrogen-rich water (drinking)", "method_keys": "bath-topical; drinking-hrw", "indications": "Metabolic; Cardiovascular; Skin / Aging; Fundamentals / Safety", "indication_keys": "metabolic; cardiovascular; skin-aging; fundamentals-safety", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "31938004", "year": 2019, "title": "Short-term H2 inhalation improves running performance and torso strength in healthy adults.", "authors": "Javorac et al.", "journal": "Biology of sport", "doi": "10.5114/biolsport.2019.88756", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/31938004/", "doi_url": "https://doi.org/10.5114/biolsport.2019.88756", "page_url": "https://h2medicine.org/studies/study-javorac-2019-short-term-inhalation-running-performance/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Sports / Performance", "indication_keys": "sports-exercise", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "30918832", "year": 2019, "title": "Acute Supplementation with Molecular Hydrogen Benefits Submaximal Exercise Indices. Randomized, Double-Blinded, Placebo-Controlled Crossover Pilot Study.", "authors": "LeBaron et al.", "journal": "Journal of lifestyle medicine", "doi": "10.15280/jlm.2019.9.1.36", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/30918832/", "doi_url": "https://doi.org/10.15280/jlm.2019.9.1.36", "page_url": "https://h2medicine.org/studies/study-lebaron-2019-acute-supplementation-submaximal-exercise/", "methods": "Tablets / Magnesium", "method_keys": "tablets", "indications": "Sports / Performance", "indication_keys": "sports-exercise", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "30227423", "year": 2019, "title": "Breathing Hydrogen-Oxygen Mixture Decreases Inspiratory Effort in Patients with Tracheal Stenosis.", "authors": "Zhou et al.", "journal": "Respiration; international review of thoracic diseases", "doi": "10.1159/000492031", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/30227423/", "doi_url": "https://doi.org/10.1159/000492031", "page_url": "https://h2medicine.org/studies/study-zhou-2019-inspiratory-effort-tracheal-stenosis/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Respiratory / Lung", "indication_keys": "respiratory", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "30207619", "year": 2018, "title": "Randomized, double-blind, multicenter trial of hydrogen water for Parkinson's disease.", "authors": "Yoritaka et al.", "journal": "Movement disorders : official journal of the Movement Disorder Society", "doi": "10.1002/mds.27472", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/30207619/", "doi_url": "https://doi.org/10.1002/mds.27472", "page_url": "https://h2medicine.org/studies/study-yoritaka-2018-multicenter-parkinson-disease/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Neurology / Brain", "indication_keys": "neurology", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "29798076", "year": 2018, "title": "[Clinical study of hydrogen-rich saline in the treatment of moderate to severe allergic rhinitis].", "authors": "Jin et al.", "journal": "Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery", "doi": "10.13201/j.issn.1001-1781.2018.07.004", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/29798076/", "doi_url": "https://doi.org/10.13201/j.issn.1001-1781.2018.07.004", "page_url": "https://h2medicine.org/studies/study-jin-2018-saline-moderate-severe-allergic/", "methods": "Saline i.v.; Bath / topical", "method_keys": "saline-iv; bath-topical", "indications": "Allergy; Fundamentals / Safety", "indication_keys": "allergy; fundamentals-safety", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "29110615", "year": 2018, "title": "Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment.", "authors": "Nishimaki et al.", "journal": "Current Alzheimer research", "doi": "10.2174/1567205014666171106145017", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/29110615/", "doi_url": "https://doi.org/10.2174/1567205014666171106145017", "page_url": "https://h2medicine.org/studies/study-nishimaki-2018-assessed-animal-model-mild/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Neurology / Brain; Cardiovascular; Oxidative stress", "indication_keys": "neurology; cardiovascular; oxidative-stress", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "28560519", "year": 2018, "title": "Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women.", "authors": "Korovljev et al.", "journal": "Irish journal of medical science", "doi": "10.1007/s11845-017-1638-4", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/28560519/", "doi_url": "https://doi.org/10.1007/s11845-017-1638-4", "page_url": "https://h2medicine.org/studies/study-korovljev-2018-affects-body-composition-metabolic/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Diabetes; Metabolic; Fundamentals / Safety", "indication_keys": "diabetes; metabolic; fundamentals-safety", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "30586410", "year": 2018, "title": "Quantification of hydrogen production by intestinal bacteria that are specifically dysregulated in Parkinson's disease.", "authors": "Suzuki et al.", "journal": "PloS one", "doi": "10.1371/journal.pone.0208313", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/30586410/", "doi_url": "https://doi.org/10.1371/journal.pone.0208313", "page_url": "https://h2medicine.org/studies/study-suzuki-2018-quantification-production-intestinal-bacteria/", "methods": "", "method_keys": "", "indications": "Neurology / Brain", "indication_keys": "neurology", "evidence_level": 2, "therapeutic": 0, "h2category": "byproduct" }, { "pmid": "30382050", "year": 2018, "title": "[Immunological Effect of Hydrogen Gas-Hydrogen Gas Improves Clinical Outcomes of Cancer Patients].", "authors": "Akagi", "journal": "Gan to kagaku ryoho. Cancer & chemotherapy", "doi": null, "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/30382050/", "doi_url": null, "page_url": "https://h2medicine.org/studies/study-akagi-2018-immunological-improves-outcomes-cancer/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Cancer / Oncology", "indication_keys": "cancer", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "29795283", "year": 2018, "title": "Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques.", "authors": "Zhu et al.", "journal": "Scientific reports", "doi": "10.1038/s41598-018-26388-3", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/29795283/", "doi_url": "https://doi.org/10.1038/s41598-018-26388-3", "page_url": "https://h2medicine.org/studies/study-zhu-2018-positive-bathing-psoriasis-parapsoriasis/", "methods": "Bath / topical; Hydrogen-rich water (drinking)", "method_keys": "bath-topical; drinking-hrw", "indications": "Skin / Aging; Immune system; Oxidative stress", "indication_keys": "skin-aging; immune-system; oxidative-stress", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "29512923", "year": 2018, "title": "Modulation of the oxidative plasmatic state in gastroesophageal reflux disease with the addition of rich water molecular hydrogen: A new biological vision.", "authors": "Franceschelli et al.", "journal": "Journal of cellular and molecular medicine", "doi": "10.1111/jcmm.13569", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/29512923/", "doi_url": "https://doi.org/10.1111/jcmm.13569", "page_url": "https://h2medicine.org/studies/study-franceschelli-2018-modulation-oxidative-plasmatic-state/", "methods": "Unspecified", "method_keys": "unspecified", "indications": "Cardiovascular; Oxidative stress", "indication_keys": "cardiovascular; oxidative-stress", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "29321509", "year": 2018, "title": "Novel haemodialysis (HD) treatment employing molecular hydrogen (H2)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study.", "authors": "Nakayama et al.", "journal": "Scientific reports", "doi": "10.1038/s41598-017-18537-x", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/29321509/", "doi_url": "https://doi.org/10.1038/s41598-017-18537-x", "page_url": "https://h2medicine.org/studies/study-nakayama-2018-haemodialysis-employing-enriched-dialysis/", "methods": "Unspecified", "method_keys": "unspecified", "indications": "Liver; Cardiovascular; Kidney / Dialysis; Immune system", "indication_keys": "liver; cardiovascular; kidney-dialysis; immune-system", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "28474871", "year": 2018, "title": "Effects of hydrogen rich water on prolonged intermittent exercise.", "authors": "Da Ponte et al.", "journal": "The Journal of sports medicine and physical fitness", "doi": "10.23736/s0022-4707.17.06883-9", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/28474871/", "doi_url": "https://doi.org/10.23736/s0022-4707.17.06883-9", "page_url": "https://h2medicine.org/studies/study-daponte-2018-prolonged-intermittent-exercise/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Sports / Performance; Cardiovascular", "indication_keys": "sports-exercise; cardiovascular", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "30713666", "year": 2018, "title": "Inhalation of hydrogen gas elevates urinary 8-hydroxy-2'-deoxyguanine in Parkinson's disease.", "authors": "Hirayama et al.", "journal": "Medical gas research", "doi": "10.4103/2045-9912.248264", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/30713666/", "doi_url": "https://doi.org/10.4103/2045-9912.248264", "page_url": "https://h2medicine.org/studies/study-hirayama-2018-inhalation-elevates-urinary-parkinsons/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Neurology / Brain; Oxidative stress", "indication_keys": "neurology; oxidative-stress", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "30257503", "year": 2018, "title": "Involvement of Neutrophil Dynamics and Function in Exercise-Induced Muscle Damage and Delayed-Onset Muscle Soreness: Effect of Hydrogen Bath.", "authors": "Kawamura et al.", "journal": "Antioxidants (Basel, Switzerland)", "doi": "10.3390/antiox7100127", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/30257503/", "doi_url": "https://doi.org/10.3390/antiox7100127", "page_url": "https://h2medicine.org/studies/study-kawamura-2018-neutrophil-muscle-soreness-bath/", "methods": "Bath / topical", "method_keys": "bath-topical", "indications": "Sports / Performance; Immune system", "indication_keys": "sports-exercise; immune-system", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "30713665", "year": 2018, "title": "Effects of the long-term consumption of hydrogen-rich water on the antioxidant activity and the gut flora in female juvenile soccer players from Suzhou, China.", "authors": "Sha et al.", "journal": "Medical gas research", "doi": "10.4103/2045-9912.248263", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/30713665/", "doi_url": "https://doi.org/10.4103/2045-9912.248263", "page_url": "https://h2medicine.org/studies/study-sha-2018-consumption-antioxidant-gut-flora/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Sports / Performance; Oxidative stress; Immune system", "indication_keys": "sports-exercise; oxidative-stress; immune-system", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "29058596", "year": 2017, "title": "Efficacy of inhaled HYdrogen on neurological outcome following BRain Ischemia During post-cardiac arrest care (HYBRID II trial): study protocol for a randomized controlled trial.", "authors": "Tamura et al.", "journal": "Trials", "doi": "10.1186/s13063-017-2246-3", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/29058596/", "doi_url": "https://doi.org/10.1186/s13063-017-2246-3", "page_url": "https://h2medicine.org/studies/study-tamura-2017-inhaled-neurological-outcome-following/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Neurology / Brain; Cardiovascular; Fundamentals / Safety", "indication_keys": "neurology; cardiovascular; fundamentals-safety", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "28669654", "year": 2017, "title": "Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection.", "authors": "Ono et al.", "journal": "Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association", "doi": "10.1016/j.jstrokecerebrovasdis.2017.06.012", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/28669654/", "doi_url": "https://doi.org/10.1016/j.jstrokecerebrovasdis.2017.06.012", "page_url": "https://h2medicine.org/studies/study-ono-2017-inhalation-acute-cerebral-infarction/", "methods": "Inhalation (H₂ gas); Saline i.v.", "method_keys": "inhalation; saline-iv", "indications": "Sports / Performance; Neurology / Brain; Skin / Aging; Oxidative stress; Fundamentals / Safety", "indication_keys": "sports-exercise; neurology; skin-aging; oxidative-stress; fundamentals-safety", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "28902900", "year": 2017, "title": "Possible clinical effects of molecular hydrogen (H2) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation.", "authors": "Nakayama et al.", "journal": "PloS one", "doi": "10.1371/journal.pone.0184535", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/28902900/", "doi_url": "https://doi.org/10.1371/journal.pone.0184535", "page_url": "https://h2medicine.org/studies/study-nakayama-2017-possible-delivery-during-hemodialysis/", "methods": "Unspecified", "method_keys": "unspecified", "indications": "Liver; Sports / Performance; Cardiovascular; Kidney / Dialysis; Immune system; Oxidative stress", "indication_keys": "liver; sports-exercise; cardiovascular; kidney-dialysis; immune-system; oxidative-stress", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "28374556", "year": 2017, "title": "Therapeutic effects of hydrogen on chronic graft-versus-host disease.", "authors": "Qian et al.", "journal": "Journal of cellular and molecular medicine", "doi": "10.1111/jcmm.13155", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/28374556/", "doi_url": "https://doi.org/10.1111/jcmm.13155", "page_url": "https://h2medicine.org/studies/study-qian-2017-therapeutic-chronic-graft-versus/", "methods": "Saline i.v.", "method_keys": "saline-iv", "indications": "Skin / Aging; Immune system; Oxidative stress", "indication_keys": "skin-aging; immune-system; oxidative-stress", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "28321000", "year": 2017, "title": "The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction　- First Pilot Study in Humans.", "authors": "Katsumata et al.", "journal": "Circulation journal : official journal of the Japanese Circulation Society", "doi": "10.1253/circj.cj-17-0105", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/28321000/", "doi_url": "https://doi.org/10.1253/circj.cj-17-0105", "page_url": "https://h2medicine.org/studies/study-katsumata-2017-inhalation-adverse-left-ventricular/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Neurology / Brain; Skin / Aging", "indication_keys": "neurology; skin-aging", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "29142752", "year": 2017, "title": "Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy.", "authors": "Yang et al.", "journal": "Molecular and clinical oncology", "doi": "10.3892/mco.2017.1409", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/29142752/", "doi_url": "https://doi.org/10.3892/mco.2017.1409", "page_url": "https://h2medicine.org/studies/study-yang-2017-liver-function-colorectal-mfolfox6/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Cancer / Oncology; Liver", "indication_keys": "cancer; liver", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "29497485", "year": 2017, "title": "Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life.", "authors": "Mizuno et al.", "journal": "Medical gas research", "doi": "10.4103/2045-9912.222448", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/29497485/", "doi_url": "https://doi.org/10.4103/2045-9912.222448", "page_url": "https://h2medicine.org/studies/study-mizuno-2017-mood-anxiety-autonomic-nerve/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Neurology / Brain", "indication_keys": "neurology", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "27938540", "year": 2016, "title": "[Protective effect of hydrogen on the lung of sanitation workers exposed to haze].", "authors": "Gong et al.", "journal": "Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases", "doi": "10.3760/cma.j.issn.1001-0939.2016.12.003", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/27938540/", "doi_url": "https://doi.org/10.3760/cma.j.issn.1001-0939.2016.12.003", "page_url": "https://h2medicine.org/studies/study-gong-2016-protective-lung-sanitation-workers/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Respiratory / Lung; Immune system; Oxidative stress", "indication_keys": "respiratory; immune-system; oxidative-stress", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "27176725", "year": 2016, "title": "A randomized double-blind multi-center trial of hydrogen water for Parkinson's disease: protocol and baseline characteristics.", "authors": "Yoritaka et al.", "journal": "BMC neurology", "doi": "10.1186/s12883-016-0589-0", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/27176725/", "doi_url": "https://doi.org/10.1186/s12883-016-0589-0", "page_url": "https://h2medicine.org/studies/study-yoritaka-2016-multi-center-parkinson-disease/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Neurology / Brain", "indication_keys": "neurology", "evidence_level": 3, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "27448107", "year": 2016, "title": "Molecular hydrogen in human breath: a new strategy for selectively diagnosing peptic ulcer disease, non-ulcerous dyspepsia and Helicobacter pylori infection.", "authors": "Maity et al.", "journal": "Journal of breath research", "doi": "10.1088/1752-7155/10/3/036007", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/27448107/", "doi_url": "https://doi.org/10.1088/1752-7155/10/3/036007", "page_url": "https://h2medicine.org/studies/study-maity-2016-breath-strategy-selectively-diagnosing/", "methods": "", "method_keys": "", "indications": "Respiratory / Lung", "indication_keys": "respiratory", "evidence_level": 2, "therapeutic": 0, "h2category": "breath-test" }, { "pmid": "27334126", "year": 2016, "title": "Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome　- First-in-Human Pilot Study.", "authors": "Tamura et al.", "journal": "Circulation journal : official journal of the Japanese Circulation Society", "doi": "10.1253/circj.cj-16-0127", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/27334126/", "doi_url": "https://doi.org/10.1253/circj.cj-16-0127", "page_url": "https://h2medicine.org/studies/study-tamura-2016-feasibility-inhalation-post-cardiac/", "methods": "Inhalation (H₂ gas)", "method_keys": "inhalation", "indications": "Neurology / Brain; Fundamentals / Safety", "indication_keys": "neurology; fundamentals-safety", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "26028929", "year": 2015, "title": "Determination of rifaximin treatment period according to lactulose breath test values in nonconstipated irritable bowel syndrome subjects.", "authors": "Bae et al.", "journal": "Journal of Korean medical science", "doi": "10.3346/jkms.2015.30.6.757", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/26028929/", "doi_url": "https://doi.org/10.3346/jkms.2015.30.6.757", "page_url": "https://h2medicine.org/studies/study-bae-2015-determination-rifaximin-period-according/", "methods": "", "method_keys": "", "indications": "Other", "indication_keys": "other", "evidence_level": 2, "therapeutic": 0, "h2category": "breath-test" }, { "pmid": "25962664", "year": 2015, "title": "Hydrogen gas production is associated with reduced interleukin-1β mRNA in peripheral blood after a single dose of acarbose in Japanese type 2 diabetic patients.", "authors": "Tamasawa et al.", "journal": "European journal of pharmacology", "doi": "10.1016/j.ejphar.2015.04.051", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/25962664/", "doi_url": "https://doi.org/10.1016/j.ejphar.2015.04.051", "page_url": "https://h2medicine.org/studies/study-tamasawa-2015-production-associated-reduced-interleukin/", "methods": "", "method_keys": "", "indications": "Diabetes; Oxidative stress", "indication_keys": "diabetes; oxidative-stress", "evidence_level": 2, "therapeutic": 0, "h2category": "byproduct" }, { "pmid": "25936373", "year": 2015, "title": "Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases.", "authors": "Ishibashi et al.", "journal": "Molecular medicine reports", "doi": "10.3892/mmr.2015.3707", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/25936373/", "doi_url": "https://doi.org/10.3892/mmr.2015.3707", "page_url": "https://h2medicine.org/studies/study-ishibashi-2015-improvement-psoriasis-associated-arthritis/", "methods": "Inhalation (H₂ gas); Saline i.v.; Hydrogen-rich water (drinking)", "method_keys": "inhalation; saline-iv; drinking-hrw", "indications": "Cancer / Oncology; Skin / Aging; Joints / Rheumatology; Immune system; Oxidative stress", "indication_keys": "cancer; skin-aging; joints-rheumatology; immune-system; oxidative-stress", "evidence_level": 2, "therapeutic": 1, "h2category": "therapy" }, { "pmid": "25978109", "year": 2015, "title": "Hydrogen Activates ATP-Binding Cassette Transporter A1-Dependent Efflux Ex Vivo and Improves High-Density Lipoprotein Function in Patients With Hypercholesterolemia: A Double-Blinded, Randomized, and Placebo-Controlled Trial.", "authors": "Song et al.", "journal": "The Journal of clinical endocrinology and metabolism", "doi": "10.1210/jc.2015-1321", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/25978109/", "doi_url": "https://doi.org/10.1210/jc.2015-1321", "page_url": "https://h2medicine.org/studies/study-song-2015-efflux-lipoprotein-function-hypercholesterolemia/", "methods": "Hydrogen-rich water (drinking)", "method_keys": "drinking-hrw", "indications": "Cardiovascular; 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N. 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Respiratory / Lung", "indication_keys": "sports-exercise; respiratory", "evidence_level": 3, "therapeutic": 0, "h2category": "breath-test" }, { "pmid": "9867093", "year": 1998, "title": "Fructose-sorbitol malabsorption and symptom provocation in irritable bowel syndrome: relationship to enteric hypersensitivity and dysmotility.", "authors": "Evans et al.", "journal": "Scandinavian journal of gastroenterology", "doi": "10.1080/00365529850172502", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/9867093/", "doi_url": "https://doi.org/10.1080/00365529850172502", "page_url": "https://h2medicine.org/studies/study-evans-1998-fructose-sorbitol-malabsorption-symptom/", "methods": "", "method_keys": "", "indications": "Other", "indication_keys": "other", "evidence_level": 3, "therapeutic": 0, "h2category": "breath-test" }, { "pmid": "9771858", "year": 1998, "title": "Energy expenditure and net substrate utilization in men ingesting usual and high amounts of nonstarch polysaccharide.", "authors": "Poppitt et al.", "journal": "The American journal of clinical nutrition", "doi": "10.1093/ajcn/68.4.820", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/9771858/", "doi_url": "https://doi.org/10.1093/ajcn/68.4.820", "page_url": "https://h2medicine.org/studies/study-poppitt-1998-energy-expenditure-net-substrate/", "methods": "", "method_keys": "", "indications": "Metabolic; Sports / Performance", "indication_keys": "metabolic; sports-exercise", "evidence_level": 3, "therapeutic": 0, "h2category": "breath-test" }, { "pmid": "9492232", "year": 1998, "title": "A one-hour active coping stressor reduces small bowel transit time in healthy young adults.", "authors": "Ditto et al.", "journal": "Psychosomatic medicine", "doi": "10.1097/00006842-199801000-00002", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/9492232/", "doi_url": "https://doi.org/10.1097/00006842-199801000-00002", "page_url": "https://h2medicine.org/studies/study-ditto-1998-one-hour-active-coping/", "methods": "", "method_keys": "", "indications": "Sports / Performance", "indication_keys": "sports-exercise", "evidence_level": 2, "therapeutic": 0, "h2category": "breath-test" }, { "pmid": "8613657", "year": 1996, "title": "How much lactose is low lactose?", "authors": "Hertzler et al.", "journal": "Journal of the American Dietetic Association", "doi": "10.1016/s0002-8223(96)00074-0", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/8613657/", "doi_url": "https://doi.org/10.1016/s0002-8223(96)00074-0", "page_url": "https://h2medicine.org/studies/study-hertzler-1996-how-much-lactose-low/", "methods": "", "method_keys": "", "indications": "Other", "indication_keys": "other", "evidence_level": 3, "therapeutic": 0, "h2category": "breath-test" }, { "pmid": "7796506", "year": 1995, "title": "Assessment of left-to-right intracardiac shunting by velocity-encoded, phase-difference magnetic resonance imaging. A comparison with oximetric and indicator dilution techniques.", "authors": "Hundley et al.", "journal": "Circulation", "doi": "10.1161/01.cir.91.12.2955", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/7796506/", "doi_url": "https://doi.org/10.1161/01.cir.91.12.2955", "page_url": "https://h2medicine.org/studies/study-hundley-1995-left-right-intracardiac-shunting/", "methods": "", "method_keys": "", "indications": "Cardiovascular; Respiratory / Lung; Skin / Aging", "indication_keys": "cardiovascular; respiratory; skin-aging", "evidence_level": 2, "therapeutic": 0, "h2category": "tracer-clearance" }, { "pmid": "7723185", "year": 1994, "title": "[Experimental and clinical studies on ischemic lesions of the large intestine].", "authors": "Mizushima et al.", "journal": "Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics", "doi": "10.3143/geriatrics.31.835", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/7723185/", "doi_url": "https://doi.org/10.3143/geriatrics.31.835", "page_url": "https://h2medicine.org/studies/study-mizushima-1994-experimental-ischemic-lesions-large/", "methods": "", "method_keys": "", "indications": "Cardiovascular", "indication_keys": "cardiovascular", "evidence_level": 2, "therapeutic": 0, "h2category": "tracer-clearance" }, { "pmid": "8062196", "year": 1994, "title": "Chemotherapy-induced lactose intolerance in adults.", "authors": "Parnes et al.", "journal": "Cancer", "doi": "10.1002/1097-0142(19940901)74:5<1629::aid-cncr2820740523>3.0.co;2-l", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/8062196/", "doi_url": "https://doi.org/10.1002/1097-0142(19940901)74:5<1629::aid-cncr2820740523>3.0.co;2-l", "page_url": "https://h2medicine.org/studies/study-parnes-1994-chemotherapy-induced-lactose-intolerance/", "methods": "", "method_keys": "", "indications": "Cancer / Oncology; Respiratory / Lung", "indication_keys": "cancer; respiratory", "evidence_level": 2, "therapeutic": 0, "h2category": "breath-test" }, { "pmid": "7949764", "year": 1994, "title": "Evaluation of tracheal mucosal blood flow during an extended radical operation for esophageal carcinoma: clinical and experimental studies.", "authors": "Nakahara et al.", "journal": "Surgery today", "doi": "10.1007/bf01833720", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/7949764/", "doi_url": "https://doi.org/10.1007/bf01833720", "page_url": "https://h2medicine.org/studies/study-nakahara-1994-tracheal-mucosal-blood-flow/", "methods": "", "method_keys": "", "indications": "Cardiovascular; Cancer / Oncology; Respiratory / Lung", "indication_keys": "cardiovascular; cancer; respiratory", "evidence_level": 2, "therapeutic": 0, "h2category": "tracer-clearance" }, { "pmid": "8112709", "year": 1993, "title": "[Effect of endogenous opioids on gastric functions in man].", "authors": "Suzuki", "journal": "[Hokkaido igaku zasshi] The Hokkaido journal of medical science", "doi": null, "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/8112709/", "doi_url": null, "page_url": "https://h2medicine.org/studies/study-suzuki-1993-endogenous-opioids-gastric-functions/", "methods": "", "method_keys": "", "indications": "Neurology / Brain", "indication_keys": "neurology", "evidence_level": 2, "therapeutic": 0, "h2category": "tracer-clearance" }, { "pmid": "8249850", "year": 1993, "title": "Hydrogen inhalation for detecting intracardiac left-to-right shunting in adults.", "authors": "Glamann et al.", "journal": "The American journal of cardiology", "doi": "10.1016/0002-9149(93)90890-o", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/8249850/", "doi_url": "https://doi.org/10.1016/0002-9149(93)90890-o", "page_url": "https://h2medicine.org/studies/study-glamann-1993-inhalation-detecting-intracardiac-left/", "methods": "", "method_keys": "", "indications": "Cardiovascular; Respiratory / Lung", "indication_keys": "cardiovascular; respiratory", "evidence_level": 2, "therapeutic": 0, "h2category": "tracer-clearance" }, { "pmid": "1792946", "year": 1991, "title": "No evidence for an effect of lactase deficiency on bone mass in pre- or postmenopausal women.", "authors": "Slemenda et al.", "journal": "Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research", "doi": "10.1002/jbmr.5650061214", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/1792946/", "doi_url": "https://doi.org/10.1002/jbmr.5650061214", "page_url": "https://h2medicine.org/studies/study-slemenda-1991-evidence-lactase-deficiency-bone/", "methods": "", "method_keys": "", "indications": "Metabolic; Women's health", "indication_keys": "metabolic; womens-health", "evidence_level": 2, "therapeutic": 0, "h2category": "breath-test" }, { "pmid": "2191785", "year": 1990, "title": "Assessment of the sensitivity of hydrogen inhalation in the detection of left-to-right shunting.", "authors": "Flores et al.", "journal": "Catheterization and cardiovascular diagnosis", "doi": "10.1002/ccd.1810200206", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/2191785/", "doi_url": "https://doi.org/10.1002/ccd.1810200206", "page_url": "https://h2medicine.org/studies/study-flores-1990-sensitivity-inhalation-detection-left/", "methods": "", "method_keys": "", "indications": "Cardiovascular; Respiratory / Lung", "indication_keys": "cardiovascular; respiratory", "evidence_level": 2, "therapeutic": 0, "h2category": "tracer-clearance" }, { "pmid": "2365796", "year": 1990, "title": "[Measurement of hepatic blood flow by the hydrogen gas clearance method. Experimental and clinical observations].", "authors": "Makino", "journal": "Nihon Ika Daigaku zasshi", "doi": "10.1272/jnms1923.57.137", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/2365796/", "doi_url": "https://doi.org/10.1272/jnms1923.57.137", "page_url": "https://h2medicine.org/studies/study-makino-1990-measurement-hepatic-blood-flow/", "methods": "", "method_keys": "", "indications": "Liver; Cancer / Oncology", "indication_keys": "liver; cancer", "evidence_level": 2, "therapeutic": 0, "h2category": "tracer-clearance" }, { "pmid": "2849711", "year": 1988, "title": "Dietary fibre and health: the role of hydrogen production.", "authors": "Neale", "journal": "Medical hypotheses", "doi": "10.1016/0306-9877(88)90091-6", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/2849711/", "doi_url": "https://doi.org/10.1016/0306-9877(88)90091-6", "page_url": "https://h2medicine.org/studies/study-neale-1988-dietary-fibre-health-production/", "methods": "", "method_keys": "", "indications": "Skin / Aging; Oxidative stress", "indication_keys": "skin-aging; oxidative-stress", "evidence_level": 2, "therapeutic": 0, "h2category": "byproduct" }, { "pmid": "3132563", "year": 1988, "title": "Effect of endocrine treatment on prostatic blood flow in patients with prostatic adenocarcinoma.", "authors": "Toma et al.", "journal": "The Journal of urology", "doi": "10.1016/s0022-5347(17)41495-9", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/3132563/", "doi_url": "https://doi.org/10.1016/s0022-5347(17)41495-9", "page_url": "https://h2medicine.org/studies/study-toma-1988-endocrine-prostatic-blood-flow/", "methods": "", "method_keys": "", "indications": "Neurology / Brain; Cancer / Oncology", "indication_keys": "neurology; cancer", "evidence_level": 2, "therapeutic": 0, "h2category": "tracer-clearance" }, { "pmid": "3348155", "year": 1988, "title": "All yogurts are not created equal.", "authors": "Wytock et al.", "journal": "The American journal of clinical nutrition", "doi": "10.1093/ajcn/47.3.454", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/3348155/", "doi_url": "https://doi.org/10.1093/ajcn/47.3.454", "page_url": "https://h2medicine.org/studies/study-wytock-1988-all-yogurts-not-created/", "methods": "", "method_keys": "", "indications": "Other", "indication_keys": "other", "evidence_level": 2, "therapeutic": 0, "h2category": "breath-test" }, { "pmid": "2963569", "year": 1988, "title": "Endoscopic measurement of gastric mucosal blood flow by laser Doppler velocimetry: effect of chronic esophageal variceal sclerosis.", "authors": "Chung et al.", "journal": "The American surgeon", "doi": null, "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/2963569/", "doi_url": null, "page_url": "https://h2medicine.org/studies/study-chung-1988-endoscopic-measurement-gastric-mucosal/", "methods": "", "method_keys": "", "indications": "Cardiovascular", "indication_keys": "cardiovascular", "evidence_level": 2, "therapeutic": 0, "h2category": "tracer-clearance" }, { "pmid": "3653647", "year": 1987, "title": "Gastroduodenal mucosal hemodynamics by endoscopic reflectance spectrophotometry.", "authors": "Leung et al.", "journal": "Gastrointestinal endoscopy", "doi": "10.1016/s0016-5107(87)71599-5", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/3653647/", "doi_url": "https://doi.org/10.1016/s0016-5107(87)71599-5", "page_url": "https://h2medicine.org/studies/study-leung-1987-gastroduodenal-mucosal-hemodynamics-endoscopic/", "methods": "", "method_keys": "", "indications": "Liver; Cardiovascular", "indication_keys": "liver; cardiovascular", "evidence_level": 2, "therapeutic": 0, "h2category": "tracer-clearance" }, { "pmid": "3303890", "year": 1987, "title": "Detection of intracardiac left-to-right shunting in adults: a prospective analysis of the variability of the standard indocyanine green technique in patients without shunting.", "authors": "Niggemann et al.", "journal": "The American journal of cardiology", "doi": "10.1016/0002-9149(87)90242-6", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/3303890/", "doi_url": "https://doi.org/10.1016/0002-9149(87)90242-6", "page_url": "https://h2medicine.org/studies/study-niggemann-1987-detection-intracardiac-left-right/", "methods": "", "method_keys": "", "indications": "Cardiovascular; Respiratory / Lung", "indication_keys": "cardiovascular; respiratory", "evidence_level": 2, "therapeutic": 0, "h2category": "tracer-clearance" }, { "pmid": "3095080", "year": 1986, "title": "Comparison of oral lavage methods for preoperative colonic cleansing.", "authors": "Beck et al.", "journal": "Diseases of the colon and rectum", "doi": "10.1007/bf02555311", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/3095080/", "doi_url": "https://doi.org/10.1007/bf02555311", "page_url": "https://h2medicine.org/studies/study-beck-1986-comparison-oral-lavage-methods/", "methods": "", "method_keys": "", "indications": "Other", "indication_keys": "other", "evidence_level": 3, "therapeutic": 0, "h2category": "byproduct" }, { "pmid": "3749634", "year": 1986, "title": "[Measurement of skin blood flow using inhaled hydrogen gas clearance method].", "authors": "Nohara et al.", "journal": "Kokyu to junkan. Respiration & circulation", "doi": null, "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/3749634/", "doi_url": null, "page_url": "https://h2medicine.org/studies/study-nohara-1986-measurement-skin-blood-flow/", "methods": "", "method_keys": "", "indications": "Skin / Aging", "indication_keys": "skin-aging", "evidence_level": 2, "therapeutic": 0, "h2category": "tracer-clearance" }, { "pmid": "3485763", "year": 1986, "title": "[Etiopathogenesis of hemorrhagic gastritis after esophageal transection extended devascularization in variceal patients].", "authors": "Satani", "journal": "Nihon Geka Gakkai zasshi", "doi": null, "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/3485763/", "doi_url": null, "page_url": "https://h2medicine.org/studies/study-satani-1986-etiopathogenesis-hemorrhagic-gastritis-after/", "methods": "", "method_keys": "", "indications": "Cardiovascular", "indication_keys": "cardiovascular", "evidence_level": 2, "therapeutic": 0, "h2category": "tracer-clearance" }, { "pmid": "2990189", "year": 1985, "title": "Dietary fiber effects on passage rate and breath hydrogen.", "authors": "Hanson et al.", "journal": "The American journal of clinical nutrition", "doi": "10.1093/ajcn/42.1.44", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/2990189/", "doi_url": "https://doi.org/10.1093/ajcn/42.1.44", "page_url": "https://h2medicine.org/studies/study-hanson-1985-dietary-fiber-passage-rate/", "methods": "", "method_keys": "", "indications": "Other", "indication_keys": "other", "evidence_level": 2, "therapeutic": 0, "h2category": "breath-test" }, { "pmid": "3989351", "year": 1985, "title": "Intestinal metabolism of a random-bonded polyglucose bulking agent in humans: in vitro and in vivo studies of hydrogen evolution.", "authors": "Solomons et al.", "journal": "The Journal of laboratory and clinical medicine", "doi": null, "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/3989351/", "doi_url": null, "page_url": "https://h2medicine.org/studies/study-solomons-1985-intestinal-metabolism-random-bonded/", "methods": "", "method_keys": "", "indications": "Fundamentals / Safety", "indication_keys": "fundamentals-safety", "evidence_level": 2, "therapeutic": 0, "h2category": "breath-test" }, { "pmid": "2578223", "year": 1985, "title": "Development of carbohydrate absorption in the fetus and neonate.", "authors": "Mobassaleh et al.", "journal": "Pediatrics", "doi": null, "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/2578223/", "doi_url": null, "page_url": "https://h2medicine.org/studies/study-mobassaleh-1985-development-carbohydrate-absorption-fetus/", "methods": "", "method_keys": "", "indications": "Sports / Performance; Pregnancy", "indication_keys": "sports-exercise; pregnancy", "evidence_level": 2, "therapeutic": 0, "h2category": "breath-test" }, { "pmid": "6530800", "year": 1984, "title": "[Endoscopic measurement of gastric mucosal blood flow by hydrogen gas generated by electrolysis--comparison with H2-inhalation method].", "authors": "Nishiwaki et al.", "journal": "Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology", "doi": null, "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/6530800/", "doi_url": null, "page_url": "https://h2medicine.org/studies/study-nishiwaki-1984-endoscopic-measurement-gastric-mucosal/", "methods": "", "method_keys": "", "indications": "Other", "indication_keys": "other", "evidence_level": 2, "therapeutic": 0, "h2category": "tracer-clearance" }, { "pmid": "6745722", "year": 1984, "title": "Is raised breath hydrogen related to the pathogenesis of pneumatosis coli?", "authors": "Read et al.", "journal": "Gut", "doi": "10.1136/gut.25.8.839", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/6745722/", "doi_url": "https://doi.org/10.1136/gut.25.8.839", "page_url": "https://h2medicine.org/studies/study-read-1984-raised-breath-related-pathogenesis/", "methods": "", "method_keys": "", "indications": "Other", "indication_keys": "other", "evidence_level": 2, "therapeutic": 0, "h2category": "breath-test" }, { "pmid": "6745599", "year": 1984, "title": "Endoscopical determination of gastric mucosal blood flow by the crossed thermocouple method.", "authors": "Hiramatsu et al.", "journal": "Gastroenterologia Japonica", "doi": "10.1007/bf02779172", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/6745599/", "doi_url": "https://doi.org/10.1007/bf02779172", "page_url": "https://h2medicine.org/studies/study-hiramatsu-1984-endoscopical-determination-gastric-mucosal/", "methods": "", "method_keys": "", "indications": "Other", "indication_keys": "other", "evidence_level": 2, "therapeutic": 0, "h2category": "breath-test" }, { "pmid": "6717636", "year": 1984, "title": "[The determination of hydrogen gas in the expired air for the diagnosis of carbohydrate resorption disorders].", "authors": "Dolmans et al.", "journal": "Nederlands tijdschrift voor geneeskunde", "doi": null, "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/6717636/", "doi_url": null, "page_url": "https://h2medicine.org/studies/study-dolmans-1984-determination-expired-air-diagnosis/", "methods": "", "method_keys": "", "indications": "Other", "indication_keys": "other", "evidence_level": 2, "therapeutic": 0, "h2category": "breath-test" }, { "pmid": "6749107", "year": 1984, "title": "[Experimental and clinical studies on esophago-gastric hemodynamics before and after devascularization for esophageal varices].", "authors": "Toyama", "journal": "Nihon Geka Gakkai zasshi", "doi": null, "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/6749107/", "doi_url": null, "page_url": "https://h2medicine.org/studies/study-toyama-1984-experimental-esophago-gastric-hemodynamics/", "methods": "", "method_keys": "", "indications": "Liver; Cardiovascular", "indication_keys": "liver; cardiovascular", "evidence_level": 2, "therapeutic": 0, "h2category": "tracer-clearance" }, { "pmid": "6715939", "year": 1984, "title": "[The cervical blood flow using hydrogen gas clearance method].", "authors": "Sakiyama", "journal": "Nihon Sanka Fujinka Gakkai zasshi", "doi": null, "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/6715939/", "doi_url": null, "page_url": "https://h2medicine.org/studies/study-sakiyama-1984-cervical-blood-flow-clearance/", "methods": "", "method_keys": "", "indications": "Sports / Performance; Pregnancy", "indication_keys": "sports-exercise; pregnancy", "evidence_level": 2, "therapeutic": 0, "h2category": "tracer-clearance" }, { "pmid": "6223807", "year": 1983, "title": "Laparoscopic measurement of pancreatic blood flow.", "authors": "Ishida et al.", "journal": "Endoscopy", "doi": "10.1055/s-2007-1021480", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/6223807/", "doi_url": "https://doi.org/10.1055/s-2007-1021480", "page_url": "https://h2medicine.org/studies/study-ishida-1983-laparoscopic-measurement-pancreatic-blood/", "methods": "", "method_keys": "", "indications": "Liver", "indication_keys": "liver", "evidence_level": 2, "therapeutic": 0, "h2category": "tracer-clearance" }, { "pmid": "5009552", "year": 1972, "title": "Measurements in man of focal intracerebral blood flow around depth-electrodes with hydrogen gas.", "authors": "Sem-Jacobsen et al.", "journal": "Progress in brain research", "doi": "10.1016/s0079-6123(08)60090-4", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/5009552/", "doi_url": "https://doi.org/10.1016/s0079-6123(08)60090-4", "page_url": "https://h2medicine.org/studies/study-semjacobsen-1972-measurements-man-focal-intracerebral/", "methods": "", "method_keys": "", "indications": "Other", "indication_keys": "other", "evidence_level": 2, "therapeutic": 0, "h2category": "tracer-clearance" }, { "pmid": "5790483", "year": 1969, "title": "Production and excretion of hydrogen gas in man.", "authors": "Levitt", "journal": "The New England journal of medicine", "doi": "10.1056/nejm196907172810303", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/5790483/", "doi_url": "https://doi.org/10.1056/nejm196907172810303", "page_url": "https://h2medicine.org/studies/study-levitt-1969-production-excretion-man/", "methods": "", "method_keys": "", "indications": "Other", "indication_keys": "other", "evidence_level": 2, "therapeutic": 0, "h2category": "byproduct" }, { "pmid": "4889689", "year": 1969, "title": "[Hydrogen inhalation curves in cardiologic diagnosis of children].", "authors": "Muller et al.", "journal": "Nederlands tijdschrift voor geneeskunde", "doi": null, "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/4889689/", "doi_url": null, "page_url": "https://h2medicine.org/studies/study-muller-1969-inhalation-curves-cardiologic-diagnosis/", "methods": "", "method_keys": "", "indications": "Cardiovascular", "indication_keys": "cardiovascular", "evidence_level": 2, "therapeutic": 0, "h2category": "tracer-clearance" }, { "pmid": "5378111", "year": 1969, "title": "Measurement of human uterine cervical blood flow by local hydrogen gas clearance.", "authors": "Klingenberg et al.", "journal": "Acta obstetricia et gynecologica Scandinavica", "doi": "10.3109/00016346909156661", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/5378111/", "doi_url": "https://doi.org/10.3109/00016346909156661", "page_url": "https://h2medicine.org/studies/study-klingenberg-1969-measurement-uterine-cervical-blood/", "methods": "", "method_keys": "", "indications": "Other", "indication_keys": "other", "evidence_level": 2, "therapeutic": 0, "h2category": "tracer-clearance" }, { "pmid": "5856743", "year": 1965, "title": "The use of hydrogen inhalation in the detection of intrcardiac shunts.", "authors": "Heimann et al.", "journal": "South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde", "doi": null, "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/5856743/", "doi_url": null, "page_url": "https://h2medicine.org/studies/study-heimann-1965-use-inhalation-detection-intrcardiac/", "methods": "", "method_keys": "", "indications": "Other", "indication_keys": "other", "evidence_level": 2, "therapeutic": 0, "h2category": "tracer-clearance" }, { "pmid": "5294201", "year": 1965, "title": "[Detection of minimal left-right shunts by hydrogen inhalation].", "authors": "Cosyns et al.", "journal": "Acta cardiologica", "doi": null, "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/5294201/", "doi_url": null, "page_url": "https://h2medicine.org/studies/study-cosyns-1965-detection-minimal-left-right/", "methods": "", "method_keys": "", "indications": "Other", "indication_keys": "other", "evidence_level": 2, "therapeutic": 0, "h2category": "tracer-clearance" }, { "pmid": "14068764", "year": 1963, "title": "THE CLINICAL USEFULNESS OF HYDROGEN GAS AS AN INDICATOR OF LEFT-TO-RIGHT SHUNTS.", "authors": "HUGENHOLTZ et al.", "journal": "Circulation", "doi": "10.1161/01.cir.28.4.542", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/14068764/", "doi_url": "https://doi.org/10.1161/01.cir.28.4.542", "page_url": "https://h2medicine.org/studies/study-hugenholtz-1963-usefulness-indicator-left-right/", "methods": "", "method_keys": "", "indications": "Other", "indication_keys": "other", "evidence_level": 2, "therapeutic": 0, "h2category": "tracer-clearance" }, { "pmid": "13810467", "year": 1959, "title": "Left-to-right shunt detection by an intravascular electrode with hydrogen as an indicator.", "authors": "CLARK LC Jr et al.", "journal": "Science (New York, N.Y.)", "doi": "10.1126/science.130.3377.709", "pubmed_url": "https://pubmed.ncbi.nlm.nih.gov/13810467/", "doi_url": "https://doi.org/10.1126/science.130.3377.709", "page_url": "https://h2medicine.org/studies/study-clarklcjr-1959-left-right-shunt-detection/", "methods": "", "method_keys": "", "indications": "Cardiovascular; Respiratory / Lung", "indication_keys": "cardiovascular; respiratory", "evidence_level": 2, "therapeutic": 0, "h2category": "tracer-clearance" } ] }