2015 · Ohta — Initiation, Development and Potential of Hydrogen Medicine: Toward Therapeutic and Preventive Applications of Molecular Hydrogen Against a Variety of Diseases
Super-Abstract
This review by Shigeo Ohta — one of the field's founding scientists — traces the history of hydrogen medicine from its 2007 origins, surveys the mechanistic and clinical evidence across multiple disease areas, and outlines future research directions. As a review article, it synthesizes existing literature rather than presenting new experimental data. (Seikagaku / Journal of the Japanese Biochemical Society, 2015.)
Commentary
Shigeo Ohta co-authored the landmark 2007 Nature Medicine paper that launched modern hydrogen medicine by showing inhaled H₂ gas protected against ischemia-reperfusion brain injury in rats. In this 2015 review, Ohta takes stock of nearly a decade of follow-up research. The abstract is not available in this database record (empty abstract field), which limits the ability to fully summarize the paper's specific arguments and findings. Based on the title and Ohta's known work, the review likely covers: the original antioxidant mechanism (selective •OH and ONOO⁻ scavenging), subsequent discoveries of signal modulation and gene expression effects, preclinical findings across oxidative-stress-related diseases (metabolic, neurological, oncological, cardiovascular), early clinical and human data, and a forward-looking assessment of the field's potential. As a Japanese-language journal article (Seikagaku), the full text may require access through the publisher.
Key quotes
- „Initiation, development and potential of hydrogen medicine: Toward therapeutic and preventive applications of molecular hydrogen against a variety of diseases.“ — the paper's scope as stated in the title — full abstract not available in this record
Our assessment
This is a narrative review by one of the founders of hydrogen medicine — not a new experimental study. As a review, it summarizes and interprets existing literature; findings should be understood as the author's synthesis and perspective rather than independent new evidence. The abstract is absent from this database record, making complete evaluation here impossible. As a review, it does not constitute direct clinical evidence, but can provide useful orientation within the field. Readers should access the full text via the journal or DOI for complete arguments.
Study design
- Type: narrative review · Scope: history and development of hydrogen medicine, mechanistic basis, preclinical and clinical evidence across multiple disease areas · H₂ angle: molecular hydrogen as therapeutic and preventive agent
- Result: synthesis of field — specific findings not evaluable without full abstract; review does not present new experimental data
Source & links
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