2024 · Glevicka — Perspective Targeted Diagnosis and Therapy of Mitochondrial Bioenergetics Across Different Diagnoses
Super-Abstract
This review explores innovative ways to diagnose and treat mitochondrial dysfunction — a root cause shared across many diseases — using high-resolution respirometry (HRR) of blood platelets as a minimally invasive diagnostic tool. Among the therapeutic strategies discussed, molecular hydrogen is listed alongside coenzyme Q10, mitochondrial transplantation, and platelet-rich plasma as an approach to reduce oxidative stress and improve mitochondrial function. This is a literature review; no new experimental data are presented.
Commentary
Mitochondrial dysfunction underpins a wide spectrum of conditions, yet clinical diagnosis has remained imprecise. This review promotes high-resolution respirometry (HRR) of peripheral blood platelets as a sensitive, early-detection method — capable of catching subtle bioenergetic changes before clinical symptoms fully develop. Molecular hydrogen (H₂) appears as one of several therapeutic options noted to ameliorate mitochondrial function and oxidative stress, alongside coenzyme Q10, mitochondrial transplantation, and platelet-rich plasma. H₂'s mention here is within a broad multi-strategy context rather than as the central focus; the depth of coverage on H₂ specifically is limited compared to a dedicated H₂ review. The paper is primarily a clinical diagnostics and therapeutic strategy overview.
Key quotes
- „Supplementing with coenzyme Q10, applying molecular hydrogen, transplanting mitochondria, and applying platelet-rich plasma (PRP) are some of the therapeutic strategies utilized to enhance mitochondrial function and reduce oxidative stress.“ — H₂ listed among mitochondria-targeted therapeutic strategies
- „High-resolution respirometry (HRR), is a minimally invasive technique that enables the analysis of mitochondrial function in platelets taken from peripheral blood.“ — the diagnostic innovation proposed — measuring mitochondrial function in blood platelets
- „Determining mitochondrial function and endogenous levels of CoQ10 in platelets can aid in the early detection of pathobiochemical changes in mitochondria and assessment of treatment efficacy.“ — clinical utility of the proposed HRR approach
Our assessment
This is a review article surveying diagnostic and therapeutic approaches to mitochondrial dysfunction. H₂ is one among several listed strategies and is not systematically evaluated here in isolation. The paper adds useful clinical context — framing H₂ as part of a broader mitochondrial-medicine toolkit — but does not provide independent evidence for H₂ efficacy. Readers seeking quantitative evidence for H₂ specifically should consult dedicated H₂ reviews or clinical trials.
Study design
- Type: narrative review · n: n/a (literature analysis) · H₂ delivery: drinking hydrogen-rich water (mentioned as one modality)
- Result: no pooled effect sizes; H₂ identified as one of several mitochondria-targeting strategies alongside CoQ10, mitochondrial transplantation, and PRP; HRR of platelets proposed as diagnostic monitoring tool
Abstract
Important metabolic variables that lead to the development of many diseases, including "mitochondrial diseases," include increased oxidative stress and mitochondrial malfunction. Given that the clinical picture and metabolic alterations in individuals suspected of having mitochondrial illnesses lack distinct characteristics, the development of sensitive and specific diagnostic techniques to detect alterations in mitochondrial bioenergetics is imperative. High-resolution respirometry (HRR), is a minimally invasive technique that enables the analysis of mitochondrial function in platelets taken from peripheral blood. This method allows for the detection of even the most subtle changes prior to disease development. HRR can identify minute variations in mitochondrial bioenergetics. Determining mitochondrial function and endogenous levels of CoQ10 in platelets can aid in the early detection of pathobiochemical changes in mitochondria and assessment of treatment efficacy. When combined with the measurement of endogenous coenzyme Q10 levels, HRR may be an effective approach for early identification of compromised mitochondrial function along with monitoring the therapeutic outcomes. Supplementing with coenzyme Q10, applying molecular hydrogen, transplanting mitochondria, and applying platelet-rich plasma (PRP) are some of the therapeutic strategies utilized to enhance mitochondrial function and reduce oxidative stress (Tab. 1, Fig. 1, Ref. 62). Text in PDF www.elis.sk Keywords: mitochondrial dysfunction, oxidative stress, mitochondrial bioenergetics, high-resolution respirometry, therapeutic approaches.
Source & links
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