Molecular Hydrogen and Oral Health: Human Studies
Oral and dental health (for example periodontitis), assessed through inflammation markers.
Human studies on molecular hydrogen for Oral health. This page collects the 14 studies catalogued in this area — 3 randomized trials, 1 pilot/observational studies and 4 reviews. Listed newest first.
Human studies (4)
2026 · Tsai et al. — Effects of Hydrogen Water Gargling on Oral Mucositis and Pain in Head and Neck Cancer Patients: A Randomized Controlled Pilot Study
In a randomised pilot trial in head and neck cancer patients receiving radiotherapy or chemoradiotherapy, the group gargling with hydrogen water showed significant improvement in oral mucositis at day 7 (p = 0.04) and day 14 (p = 0.002).
2025 · Maruyama et al. — Efficacy of Oral Intake of Hydrogen-Rich Jelly Intake on Gingival Inflammation: A Double-Blind, Placebo-Controlled and Exploratory Randomized Clinical Trial
In people with gingivitis, eating hydrogen-rich jelly three times a day for 14 days showed no statistically significant difference from placebo jelly in the percentage of sites that bled on probing, the primary endpoint (p > 0.05).
2015 · Azuma et al. — Drinking Hydrogen-Rich Water Has Additive Effects on Non-Surgical Periodontal Treatment of Improving Periodontitis: A Pilot Study
In 13 patients with periodontitis, drinking hydrogen-rich water for eight weeks alongside non-surgical periodontal treatment gave greater improvements in probing pocket depth and clinical attachment level than treatment alone at two, four and eight weeks (p < 0.05).
2025 · Devi et al. — Hydrogen Water Versus Normal Saline for Post-Surgical Irrigation: A Study on Healing and Complication Rates After Third Molar Extraction
In 30 patients having impacted lower wisdom teeth removed, irrigating the surgical site with hydrogen water instead of normal saline was reported to give greater improvement in pain, swelling and restricted mouth opening and less dry socket from the second day after surgery.
Reviews (4)
2024 · Afkhami — Exploring Approaches to Pulp Vitality Assessment: A Scoping Review of Nontraditional Methods
Accurate assessment of dental pulp vitality is critical in endodontics — yet current clinical tests are imprecise.
2022 · Bai et al. — Effects of Hydrogen Rich Water and Pure Water on Periodontal Inflammatory Factor Level, Oxidative Stress Level and Oral Flora: A Systematic Review and Meta-Analysis
This meta-analysis of 17 studies found lower levels of the inflammatory markers IL-1β, TNF-α and IL-6 and of two oxidative stress markers with hydrogen-rich water than with pure water, along with less activity of oral pathogenic bacteria.
2009 · Mahlen — Oral abscess caused by Campylobacter rectus: case report and literature review.
This case report and literature review describes the first documented case of a palate abscess caused by Campylobacter rectus in a patient with gastroesophageal adenocarcinoma.
Preclinical (6)
2024 · Wang — Combined use of hydrogen-rich water and enzyme-digested edible bird's nest improves PMA/LPS-impaired wound healing in human inflammatory gingival tissue equivalents.
In a laboratory model of inflamed human gum tissue, the combination of hydrogen-rich water and a processed form of edible bird's nest significantly counteracted the wound-healing damage caused by an inflammatory stimulus.
2022 · Saitoh — Molecular hydrogen suppresses Porphyromonas gingivalis lipopolysaccharide-induced increases in interleukin-1 alpha and interleukin-6 secretion in human gingival cells.
In a laboratory cell model of periodontitis, molecular hydrogen (H₂) significantly reduced the secretion of two key inflammatory cytokines — IL-1α and IL-6 — triggered by a major periodontal pathogen.
2019 · Amberg — Effect of Physical Cues of Altered Extract Media from Biodegradable Magnesium Implants on Human Gingival Fibroblasts
As biodegradable magnesium (Mg) implants corrode, they alter the surrounding medium with elevated Mg²⁺, reduced Ca²⁺, increased osmolality, and dissolved molecular hydrogen (H₂) — all of which affect the migration rate of human gingival fibroblasts.
2018 · Zhou — Protective effects of hydrogen-rich medium on lipopolysaccharide-induced injury in human periodontal ligament cells
In cultured human periodontal ligament cells (hPDLCs) exposed to lipopolysaccharide (LPS) to simulate bacterial inflammation, hydrogen-rich medium improved cell proliferation, reduced apoptosis, and lowered oxidative stress markers.
2017 · Kim — Inhibition of Streptococcal Biofilm by Hydrogen Water
Electrolyzed hydrogen-rich water significantly inhibited streptococcal biofilm formation in laboratory cultures, reduced the expression of key biofilm-related genes, and — in a small oral-rinse trial — reduced the number of salivary streptococci compared with tap water.
2012 · Baxter et al. — Evaluation of outgassing, tear strength, and detail reproduction in alginate substitute materials.
This study compares dental impression materials (alginate substitutes) to traditional alginate for three performance properties: the release of hydrogen gas (outgassing), tear strength, and detail reproduction quality.