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Kidney / Dialysis

Kidney function and dialysis — a comparatively well-studied area, where H₂ is often delivered through the dialysis water or hydrogen-rich solutions.

Human studies on molecular hydrogen for Kidney / Dialysis. This page collects the 35 studies catalogued in this area — 0 randomized trials, 9 pilot/observational studies and 7 reviews. Listed newest first.

2026 Review / Meta-analysis Unspecified

2026 · Viana — Molecular hydrogen and kidney diseases: a scoping review based on scientometry and data analytics

Medical gas research
2025 Review / Meta-analysis Unspecified

2025 · Xu — Innovations in peritoneal dialysis fluid: biocompatible formulations and expanded therapeutic applications

Renal failure
2025 Review / Meta-analysis Inhalation

2025 · Li — Application Trends of Hydrogen-generating Nanomaterials for the Treatment of ROS-related Diseases

Biomaterials science
2024 Review / Meta-analysis Unspecified

2024 · Zheng — Potential Role of Molecular Hydrogen Therapy on Oxidative Stress and Redox Signaling in Chronic Kidney Disease

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
2018 Review / Meta-analysis Saline / IVDrinking (HRW)

2018 · Chen — Research progress of hydrogen-rich saline for eye diseases.

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology
2016 Review / Meta-analysis Unspecified

2016 · Zheng — Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis

Oxidative medicine and cellular longevity
2012 Review / Meta-analysis Drinking (HRW)

2012 · Ohno et al. — Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases.

Oxidative medicine and cellular longevity
2026 Pilot / Observational Human H₂ therapy Drinking (HRW)

2026 · Pesotskaya — Hydration Bioanalyses of the Effects of Hydrogen-Rich Water (HRW)

Wiadomosci lekarskie (Warsaw, Poland : 1960)
2025 Pilot / Observational Human H₂ therapy Drinking (HRW)

2025 · Tu et al. — Molecular Hydrogen Therapy in Rheumatoid Arthritis: A Case Report on the Amelioration of Methotrexate-induced Myelosuppression and Immune Modulation

In vivo (Athens, Greece)
2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Nakayama et al. — Hemodialysis Employing Molecular Hydrogen (H₂) Enriched Dialysis Solution May Improve Dialysis-Related Fatigue Through Impact on Energy Metabolism

Scientific reports
2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Lin et al. — Molecular Hydrogen as a Potential Adjunctive Therapy to Improve Renal Function and Reduce Fatigue in an Elderly Patient With Chronic Comorbidities: A Case Report

In vivo (Athens, Greece)
2018 Pilot / Observational Human H₂ therapy Unspecified

2018 · Nakayama — Novel Haemodialysis Treatment Employing Molecular Hydrogen-Enriched Dialysis Solution Improves Prognosis of Chronic Dialysis Patients: A Prospective Observational Study

Scientific reports
2017 Pilot / Observational Human H₂ therapy Unspecified

2017 · Nakayama et al. — Possible clinical effects of molecular hydrogen (H₂) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation.

PloS one
2010 Pilot / Observational Human H₂ therapy Inhalation

2010 · Nakayama et al. — A Novel Bioactive Haemodialysis System Using Dissolved Dihydrogen (H₂) Produced by Water Electrolysis: A Clinical Trial

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
2006 Pilot / Observational Human H₂ therapy Unspecified

2006 · Huang et al. — Electrolyzed-Reduced Water Reduced Hemodialysis-Induced Erythrocyte Impairment in End-Stage Renal Disease Patients

Kidney international
2003 Pilot / Observational Human H₂ therapy Drinking (HRW)

2003 · Huang — Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water.

Kidney international
2025 Mechanism / Preclinical Inhalation

2025 · Lu — Dietary addition of magnesium hydride nanoparticles: a breakthrough in combating high-fat diet-induced chronic kidney disease.

Medical gas research
2025 Mechanism / Preclinical Inhalation

2025 · Tian — Molecular hydrogen attenuates cisplatin-induced nephrotoxicity by modulating β-hydroxybutyrate metabolism

Molecular Biology Reports
2023 Mechanism / Preclinical Saline / IV

2023 · Guo — Hydrogen suppresses oxidative stress by inhibiting the p38 MAPK signaling pathway in preeclampsia

Advances in clinical and experimental medicine : official organ Wroclaw Medical University
2022 Mechanism / Preclinical Drinking (HRW)

2022 · Mouzakis — Quantification of dissolved H₂ and continuous monitoring of hydrogen-rich water for haemodialysis applications: An experimental study

The International journal of artificial organs
2022 Mechanism / Preclinical Inhalation

2022 · Liu — In vivo microelectrode monitoring of real-time hydrogen concentration in different tissues of rats after inhaling hydrogen gas

Medical gas research
2022 Mechanism / Preclinical Drinking (HRW)

2022 · Mizutani — Hydrogen-rich water reduced oxidative stress and renal fibrosis in rats with unilateral ureteral obstruction.

Pediatric research
2021 Mechanism / Preclinical Inhalation

2021 · van Gelder et al. — Safety of Electrooxidation for Urea Removal in a Wearable Artificial Kidney Is Compromised by Formation of Glucose Degradation Products

Artificial organs
2020 Mechanism / Preclinical Saline / IV

2020 · Lu — Molecular hydrogen regulates PTEN-AKT-mTOR signaling via ROS to alleviate peritoneal dialysis-related peritoneal fibrosis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2019 Mechanism / Preclinical Inhalation

2019 · Kobayashi — Organ Preservation Solution Containing Dissolved Hydrogen Gas from a Hydrogen-Absorbing Alloy Canister Improves Function of Transplanted Ischemic Kidneys in Miniature Pigs

PloS one
2019 Mechanism / Preclinical Drinking (HRW)

2019 · Yamasaki — Effects of hydrogen-rich water in a rat model of polycystic kidney disease.

PloS one
2019 Mechanism / Preclinical Inhalation

2019 · Liu — In vitro and in vivo studies of Mg-30Sc alloys with different phase structure for potential usage within bone.

Acta biomaterialia
2019 Mechanism / Preclinical Inhalation

2019 · Guan — Hydrogen gas reduces chronic intermittent hypoxia-induced hypertension by inhibiting sympathetic nerve activity and increasing vasodilator responses via antioxidation.

Journal of cellular biochemistry
2018 Mechanism / Preclinical Saline / IV

2018 · Nakayama — Translational Research of Peritoneal Dialysis Solution with Dissolved Molecular Hydrogen

Contributions to nephrology
2017 Mechanism / Preclinical Drinking (HRW)

2017 · Xing — Hydrogen Rich Water Attenuates Renal Injury and Fibrosis by Regulation of TGF-β-Induced Sirt1

Biological & pharmaceutical bulletin
2016 Mechanism / Preclinical Saline / IV

2016 · Du — Hydrogen-Rich Saline Attenuates Acute Kidney Injury After Liver Transplantation via Activating p53-Mediated Autophagy

Transplantation
2015 Mechanism / Preclinical Inhalation

2015 · Barbu et al. — The use of hydrogen gas clearance for blood flow measurements in single endogenous and transplanted pancreatic islets.

Microvascular research
2013 Mechanism / Preclinical Saline / IV

2013 · Xu et al. — Hydrogen-rich saline ameliorates renal injury induced by unilateral ureteral obstruction in rats.

International immunopharmacology
1999 Mechanism / Preclinical InhalationSaline / IVDrinking (HRW)

1999 · Ishikawa — A preventive effect of a selective endothelin-A receptor antagonist, S-0139, on the erythropoietin-induced reduction of the renal cortical blood flow.

Urological research
1983 Mechanism / Preclinical Inhalation

1983 · Homer — Transient solutions of equations for countercurrent capillary exchange.

The American journal of physiology