← All indications

Joints / Rheumatology

Joints and inflammatory rheumatic conditions, assessed through inflammation and pain markers.

Human studies on molecular hydrogen for Joints / Rheumatology. This page collects the 37 studies catalogued in this area — 3 randomized trials, 8 pilot/observational studies and 5 reviews. Listed newest first.

2026 Review / Meta-analysis Unspecified

2026 · Paparella — Medical Gases as Emerging Regulators of Paediatric Endocrine and Neurodevelopmental Pathways: A Mini-Review

Acta paediatrica (Oslo, Norway : 1992)

2025 Review / Meta-analysis Drinking (HRW)

2025 · Bilski — Antioxidant Therapies as Emerging Adjuncts in Rheumatoid Arthritis: Targeting Oxidative Stress to Enhance Treatment Outcomes

International journal of molecular sciences

2016 Review / Meta-analysis Unspecified

2016 · Zheng — Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis

Oxidative medicine and cellular longevity

2015 Review / Meta-analysis Unspecified

2015 · Ostojic — Molecular hydrogen in sports medicine: new therapeutic perspectives.

International journal of sports medicine

2013 Review / Meta-analysis Unspecified

2013 · Ishibashi — Molecular hydrogen: new antioxidant and anti-inflammatory therapy for rheumatoid arthritis and related diseases

Current pharmaceutical design

2021 RCT Human H₂ therapy Bath / Topical Drinking (HRW)

2021 · Javorac — Hydrotherapy with hydrogen-rich water compared with RICE protocol following acute ankle sprain in professional athletes: a randomized non-inferiority pilot trial

Research in Sports Medicine

2014 RCT Human H₂ therapy Tablets Bath / Topical Drinking (HRW)

2014 · Ostojic et al. — Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries.

Postgraduate medicine

2014 RCT Human H₂ therapy Saline / IV

2014 · Ishibashi et al. — Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study.

International immunopharmacology

2026 Pilot / Observational Human H₂ therapy Saline / IV Drinking (HRW)

2026 · Lin et al. — Adjunctive Molecular Hydrogen Therapy Modulates T Cell Markers and Reduces Anti-Ro Antibody in Refractory Oral Ulcers of Behçet's Disease and Sjögren's Syndrome: A Case Report

In vivo (Athens, Greece)

2026 Pilot / Observational Human H₂ therapy Drinking (HRW)

2026 · Tsai et al. — Rhupus Syndrome With Multiple Drug Intolerances Managed by Reduced-dose Rituximab and Adjunctive Molecular Hydrogen Therapy: A Case Report

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Drinking (HRW)

2025 · Ren et al. — A Case Report of Adjuvant Molecular Hydrogen Therapy in Refractory Rheumatoid Arthritis With Atlantoaxial Subluxation

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Drinking (HRW)

2025 · Lui et al. — Predicting Therapeutic Response to Molecular Hydrogen in Autoimmune Diseases via Immunophenotyping

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

2025 Pilot / Observational Human H₂ therapy Drinking (HRW)

2025 · Tu et al. — Molecular Hydrogen Therapy in Rheumatoid Arthritis: A Case Report on the Amelioration of Methotrexate-induced Myelosuppression and Immune Modulation

In vivo (Athens, Greece)

2024 Pilot / Observational Human H₂ therapy Drinking (HRW)

2024 · Chen — Molecular Hydrogen Therapy in Aneurysmal SAH With RA and Newly-diagnosed SLE, Complicated With Acute Ischemic Infarction: A Case Report of Improved Immune Markers Including Tr1 Cells, Breg Cells and TIM3 Expression on Tc Cells.

In vivo (Athens, Greece)

2022 Pilot / Observational

2022 · Waelti — Radiographic features of magnesium-based bioabsorbable screw resorption in paediatric fractures

Pediatric radiology

2015 Pilot / Observational Human H₂ therapy Inhalation Saline / IV Drinking (HRW)

2015 · Ishibashi et al. — Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases.

Molecular medicine reports

2026 Mechanism / Preclinical Inhalation

2026 · Zhang — Pearl-Like Bioinspired Coating Enables Regulation of Mg Degradation for Osteoporotic Bone Repair

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2025 Mechanism / Preclinical Saline / IV Drinking (HRW)

2025 · Jingxuan — Four-dimensional Data Independent Acquisition Proteomics and Metabolomics Reveal Mechanisms of Hydrogen-rich Water at Zusanli (ST36) Point against Triple-negative Breast Cancer in Mice

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

2025 Mechanism / Preclinical Inhalation

2025 · Wang — Spontaneous Hydrogen-releasing Nanoenzyme Alleviates Osteoarthritis via Oxidative Stress Reduction and Mitochondrial Dysfunction Reversal

Journal of nanobiotechnology

2025 Mechanism / Preclinical Inhalation

2025 · Maier — Biomechanical Analysis of Biodegradable Magnesium, Zinc, and Polylactide Pins for Fixation of Radial Head Fractures

Journal of orthopaedic surgery and research

2025 Mechanism / Preclinical Inhalation

2025 · Lu — Pyroptosis-responsive microspheres modulate the inflammatory microenvironment to retard osteoporosis in female mice.

Nature communications

2025 Mechanism / Preclinical Inhalation

2025 · Ji — Hydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis.

Advanced materials (Deerfield Beach, Fla.)

2025 Mechanism / Preclinical Drinking (HRW)

2025 · An — Hydrogen activates ACOD1-itaconate pathway to ameliorate steroid-associated osteonecrosis

Biomaterials

2024 Mechanism / Preclinical Unspecified

2024 · Lin — Hydrogen-treated CoCrMo alloy: a novel approach to enhance biocompatibility and mitigate inflammation in orthopedic implants.

Journal of materials chemistry. B

2024 Mechanism / Preclinical Inhalation

2024 · Chen et al. — Endogenous Melanin and Hydrogen-Based Specific Activated Theranostics Nanoagents: A Novel Multi-Treatment Paradigm for Rheumatoid Arthritis

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2024 Mechanism / Preclinical Unspecified

2024 · Yano et al. — Charge Neutralization and β-Elimination Cleavage Mechanism of Family 42 L-Rhamnose-α-1,4-D-Glucuronate Lyase Revealed Using Neutron Crystallography

The Journal of biological chemistry

2023 Mechanism / Preclinical Inhalation

2023 · Son — PdO-Nanoparticle-Embedded Carbon Nanotube Yarns for Wearable Hydrogen Gas Sensing Platforms with Fast and Sensitive Responses

ACS sensors

2022 Mechanism / Preclinical Bath / Topical Drinking (HRW)

2022 · Chen et al. — Photocatalytic Glucose Depletion and Hydrogen Generation for Diabetic Wound Healing

Nature communications

2020 Mechanism / Preclinical Unspecified

2020 · Holweg — A Lean Magnesium-Zinc-Calcium Alloy ZX00 Used for Bone Fracture Stabilization in a Large Growing-Animal Model

Acta biomaterialia

2020 Mechanism / Preclinical Unspecified

2020 · Ishihara — Molecular hydrogen suppresses superoxide generation in the mitochondrial complex I and reduced mitochondrial membrane potential.

Biochemical and biophysical research communications

2019 Mechanism / Preclinical Inhalation

2019 · Wu — Hydrogen gas protects against ovariectomy-induced osteoporosis by inhibiting NF-κB activation.

Menopause (New York, N.Y.)

2018 Mechanism / Preclinical Inhalation Saline / IV

2018 · Wan — An In Situ Depot for Continuous Evolution of Gaseous H₂ Mediated by a Magnesium Passivation/Activation Cycle for Treating Osteoarthritis

Angewandte Chemie (International ed. in English)

2017 Mechanism / Preclinical Saline / IV

2017 · Li — Protective Effects of Molecular Hydrogen on Steroid-Induced Osteonecrosis in Rabbits via Reducing Oxidative Stress and Apoptosis

BMC musculoskeletal disorders

2016 Mechanism / Preclinical Drinking (HRW)

2016 · Lin — Molecular Hydrogen Suppresses Activated Wnt/β-catenin Signaling

Scientific reports

2015 Mechanism / Preclinical Unspecified

2015 · Yu et al. — Protective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and vascular endothelial permeability through regulation of vascular endothelial cadherin.

Genetics and molecular research : GMR

2010 Mechanism / Preclinical Inhalation

2010 · Wong — A biodegradable polymer-based coating to control the performance of magnesium alloy orthopaedic implants.

Biomaterials

2008 Mechanism / Preclinical Inhalation

2008 · Hill — Preliminary tribological evaluation of nanostructured diamond coatings against ultra-high molecular weight polyethylene.

Journal of biomedical materials research. Part B, Applied biomaterials