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Diabetes

Studies on blood sugar, insulin sensitivity and diabetic complications.

Human studies on molecular hydrogen for Diabetes. This page collects the 36 studies catalogued in this area — 3 randomized trials, 8 pilot/observational studies and 14 reviews. Listed newest first.

2026 Review / Meta-analysis Inhalation

2026 · Seneff — The essential role of hydrogen gas recycling by gut microbes in reducing deuterium load in host mitochondria: is trimethylamine oxide a deuterium sensor?

Metabolomics : Official journal of the Metabolomic Society
2025 Review / Meta-analysis Drinking (HRW)

2025 · Bjørklund — Advanced Glycation End Products and Skin Autoimmune Disorders: Pathogenic Insights into Vitiligo, Bullous Pemphigoid, and Type 1 Diabetes Mellitus

Current medicinal chemistry
2024 Review / Meta-analysis Inhalation

2024 · Tsuzuki — Idiopathic Sudden Sensorineural Hearing Loss: A Review Focused on the Contribution of Vascular Pathologies

Auris, nasus, larynx
2023 Review / Meta-analysis Unspecified

2023 · Bellucci et al. — Novel Therapeutic Approaches Based on the Pathological Role of Gut Dysbiosis on the Link Between Non-Alcoholic Fatty Liver Disease and Insulin Resistance

European review for medical and pharmacological sciences
2022 Review / Meta-analysis Unspecified

2022 · Fu — Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases

Oxidative medicine and cellular longevity
2020 Review / Meta-analysis InhalationBath / TopicalDrinking (HRW)

2020 · Kawamura et al. — Application of Molecular Hydrogen as a Novel Antioxidant in Sports Science

Oxidative medicine and cellular longevity
2019 Review / Meta-analysis Inhalation

2019 · Qian — Medical Application of Hydrogen in Hematological Diseases.

Oxidative medicine and cellular longevity
2018 Review / Meta-analysis Unspecified

2018 · Zhang — Hydrogen Therapy in Cardiovascular and Metabolic Diseases: from Bench to Bedside

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
2016 Review / Meta-analysis Unspecified

2016 · Zheng — Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis

Oxidative medicine and cellular longevity
2015 Review / Meta-analysis Unspecified

2015 · Ostojic — Molecular hydrogen in sports medicine: new therapeutic perspectives.

International journal of sports medicine
2013 Review / Meta-analysis Drinking (HRW)

2013 · Takaki — Multiple hits, including oxidative stress, as pathogenesis and treatment target in non-alcoholic steatohepatitis (NASH)

International journal of molecular sciences
2013 Review / Meta-analysis Inhalation

2013 · Lucas — Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway

Molecular neurobiology
2012 Review / Meta-analysis Drinking (HRW)

2012 · Ohno et al. — Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases.

Oxidative medicine and cellular longevity
2011 Review / Meta-analysis Unspecified

2011 · Noda et al. — The principle and the potential approach to ROS-dependent cytotoxicity by non-pharmaceutical therapies: optimal use of medical gases with antioxidant properties.

Current pharmaceutical design
2024 RCT

2024 · Dawson — Early time-restricted eating improves markers of cardiometabolic health but has no impact on intestinal nutrient absorption in healthy adults.

Cell reports. Medicine
2018 RCT Human H₂ therapy Drinking (HRW)

2018 · Korovljev — Molecular Hydrogen Affects Body Composition, Metabolic Profiles, and Mitochondrial Function in Middle-Aged Overweight Women

Irish journal of medical science
2008 RCT Human H₂ therapy Drinking (HRW)

2008 · Kajiyama — Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance

Nutrition Research
2026 Pilot / Observational Human H₂ therapy Saline / IV

2026 · Xu et al. — Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via Promoting Mitophagy

Journal of diabetes
2025 Pilot / Observational

2025 · Misnikova et al. — Hydrogen and Methane Detection in Breath in Response to Two Different Types of Dietary Fiber and Its Relationship to Postprandial Glucose Concentration in Obese Patients with Type 2 Diabetes and Normoglycemic Subjects

Nutrients
2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Lin et al. — Molecular Hydrogen as a Potential Adjunctive Therapy to Improve Renal Function and Reduce Fatigue in an Elderly Patient With Chronic Comorbidities: A Case Report

In vivo (Athens, Greece)
2022 Pilot / Observational Human H₂ therapy Inhalation

2022 · Zhao — Effectiveness and safety of hydrogen inhalation as an adjunct treatment in Chinese type 2 diabetes patients: A retrospective, observational, double-arm, real-life clinical study

Frontiers in Endocrinology
2020 Pilot / Observational Human H₂ therapy Drinking (HRW)

2020 · Asada et al. — Effects of hydrogen-rich water prepared by alternating-current-electrolysis on antioxidant activity, DNA oxidative injuries, and diabetes-related markers.

Medical gas research
2015 Pilot / Observational

2015 · Tamasawa et al. — Hydrogen gas production is associated with reduced interleukin-1β mRNA in peripheral blood after a single dose of acarbose in Japanese type 2 diabetic patients.

European journal of pharmacology
2014 Pilot / Observational

2014 · Makiyama et al. — Do alpha-glucosidase inhibitors have the potential to induce portal venous gas? — Two clinical case reports.

Internal medicine (Tokyo, Japan)
2011 Pilot / Observational

2011 · Tachibe et al. — Digestibility, Fermentability, and Energy Value of Highly Cross-Linked Phosphate Tapioca Starch in Men

Journal of food science
2025 Mechanism / Preclinical Inhalation

2025 · Wang — Hierarchical ROS-scavenging platform breaks vicious cycle of stem cell senescence, angiogenesis arrest, and immune dysregulation in diabetic wounds.

Journal of controlled release : official journal of the Controlled Release Society
2025 Mechanism / Preclinical Unspecified

2025 · Yu — Protective Effects of Hydrogen Treatment Against High Glucose-Induced Oxidative Stress and Apoptosis via Inhibition of the AGEs/RAGE/NF-κB Signaling Pathway in Skin Cells.

Endocrine, metabolic & immune disorders drug targets
2024 Mechanism / Preclinical Unspecified

2024 · Xu — Poly(ionic liquid)-Flocculated Chlorella Loading Bactericidal and Antioxidant Hydrogel as a Biological Hydrogen Therapy for Diabetic Wound Dressing.

ACS applied materials & interfaces
2022 Mechanism / Preclinical Bath / TopicalDrinking (HRW)

2022 · Chen et al. — Photocatalytic Glucose Depletion and Hydrogen Generation for Diabetic Wound Healing

Nature communications
2021 Mechanism / Preclinical Unspecified

2021 · Marzullo et al. — Ammonium Formate-Pd/C as a New Reducing System for 1,2,4-Oxadiazoles: Synthesis of Guanidine Derivatives and Reductive Rearrangement to Quinazolin-4-Ones with Potential Anti-Diabetic Activity

International journal of molecular sciences
2020 Mechanism / Preclinical Unspecified

2020 · Liu — Effect of thermal treatments on in vitro starch digestibility of sorghum dried noodles.

Food & function
2020 Mechanism / Preclinical Saline / IVDrinking (HRW)

2020 · Jiao — Protective effects of hydrogen-rich saline against experimental diabetic peripheral neuropathy via activation of the mitochondrial ATP-sensitive potassium channel in rats.

Molecular medicine reports
2016 Mechanism / Preclinical Unspecified

2016 · Zhang — How the Imidazole Ring Modulates Amyloid Formation of Islet Amyloid Polypeptide: A Chemical Modification Study

Biochimica et biophysica acta
2014 Mechanism / Preclinical Inhalation

2014 · Nazreen et al. — Thiazolidine-2,4-diones derivatives as PPAR-γ agonists: synthesis, molecular docking, in vitro and in vivo antidiabetic activity with hepatotoxicity risk evaluation.

Bioorganic & medicinal chemistry letters
2013 Mechanism / Preclinical Unspecified

2013 · Alexandrescu — Amide proton solvent protection in amylin fibrils probed by quenched hydrogen exchange NMR.

PloS one
2011 Mechanism / Preclinical Unspecified

2011 · Yu — Hydrogen-Rich Medium Protects Human Skin Fibroblasts from High Glucose or Mannitol Induced Oxidative Damage

Biochemical and biophysical research communications