H2medicine
← All indications

Fundamentals / Safety

Fundamentals and safety: studies on tolerability, dosing, pharmacokinetics and measurement methods of H₂ in humans.

Human studies on molecular hydrogen for Fundamentals / Safety. This page collects the 57 studies catalogued in this area — 8 randomized trials, 13 pilot/observational studies and 17 reviews. Listed newest first.

2026 Review / Meta-analysis InhalationSaline / IVDrinking (HRW)

2026 · Nguyen — Advances in hydrogen delivery strategies for therapeutic applications

Advanced drug delivery reviews
2026 Review / Meta-analysis Inhalation

2026 · Pan — Stimuli-Responsive Hydrogen Production from Nanomaterials: Design, Regulation and Biomedical Applications

Advanced healthcare materials
2025 Review / Meta-analysis Unspecified

2025 · Xie — Mechanisms and Protective Strategies for Astronaut Skin Injury in Deep Space Environments

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
2025 Review / Meta-analysis Drinking (HRW)

2025 · Bilski — Antioxidant Therapies as Emerging Adjuncts in Rheumatoid Arthritis: Targeting Oxidative Stress to Enhance Treatment Outcomes

International journal of molecular sciences
2025 Review / Meta-analysis Unspecified

2025 · Neykhonji — Exploring the Potential of H₂ Therapy in Reducing Surgical Complications: A Review on Anti-inflammatory, Antioxidant, and Anti-fibrotic Mechanisms

Current pharmaceutical design
2025 Review / Meta-analysis Inhalation

2025 · Li — Application Trends of Hydrogen-generating Nanomaterials for the Treatment of ROS-related Diseases

Biomaterials science
2024 Review / Meta-analysis Unspecified

2024 · Khiji — The Therapeutic Application of Hydrogen in Cancer: The Potential and Challenges

Current pharmaceutical design
2022 Review / Meta-analysis Unspecified

2022 · Ahmad et al. — Narrative on Hydrogen Therapy and its Clinical Applications: Safety and Efficacy

Current pharmaceutical design
2021 Review / Meta-analysis Unspecified

2021 · Hirano — Molecular Hydrogen as a Novel Antitumor Agent: Possible Mechanisms Underlying Gene Expression.

International journal of molecular sciences
2021 Review / Meta-analysis Inhalation

2021 · Magliocca et al. — Inhaled gases as novel neuroprotective therapies in the postcardiac arrest period.

Current opinion in critical care
2021 Review / Meta-analysis Unspecified

2021 · Shi et al. — Hydrogen treatment: a novel option in liver diseases.

Clinical medicine (London, England)
2021 Review / Meta-analysis Inhalation

2021 · Li et al. — Hydrogen Commonly Applicable from Medicine to Agriculture: From Molecular Mechanisms to the Field.

Current pharmaceutical design
2021 Review / Meta-analysis Unspecified

2021 · Domoki — Hydrogen-induced Neuroprotection in Neonatal Hypoxic-ischemic Encephalopathy.

Current pharmaceutical design
2021 Review / Meta-analysis Unspecified

2021 · Chen et al. — Neuroprotective Effects of Molecular Hydrogen: A Critical Review.

Neuroscience bulletin
2021 Review / Meta-analysis Inhalation

2021 · Htun et al. — Hydrogen and Therapeutic Gases for Neonatal Hypoxic-Ischemic Encephalopathy: Potential Neuroprotective Adjuncts in Translational Research

Pediatric research
2019 Review / Meta-analysis Inhalation

2019 · Wu — Hydrogen Gas from Inflammation Treatment to Cancer Therapy

ACS nano
2013 Review / Meta-analysis Inhalation

2013 · Zheng — Equol: a metabolite of soy isoflavones by intestinal microflora — a review

Wei sheng wu xue bao = Acta microbiologica Sinica
2025 RCT Human H₂ therapy Unspecified

2025 · Shogenova — Efficiency and Safety of the Combined Use of Thermal Heliox, Nitric Oxide and Molecular Hydrogen in COPD Exacerbation with Respiratory Failure and Pulmonary Hypertension in the Post-COVID Period

Terapevticheskii arkhiv
2019 RCT Human H₂ therapy Drinking (HRW)

2019 · Korovljev et al. — Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial.

Clinics and research in hepatology and gastroenterology
2018 RCT Human H₂ therapy Saline / IVBath / Topical

2018 · Jin — Clinical Study of Hydrogen-Rich Saline in the Treatment of Moderate to Severe Allergic Rhinitis

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery
2018 RCT Human H₂ therapy Drinking (HRW)

2018 · Korovljev — Molecular Hydrogen Affects Body Composition, Metabolic Profiles, and Mitochondrial Function in Middle-Aged Overweight Women

Irish journal of medical science
2017 RCT Human H₂ therapy Inhalation

2017 · Tamura — Efficacy of Inhaled Hydrogen on Neurological Outcome Following Brain Ischemia During Post-Cardiac Arrest Care (HYBRID II Trial): Study Protocol for a Randomized Controlled Trial

Trials
2017 RCT Human H₂ therapy InhalationSaline / IV

2017 · Ono et al. — Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
2014 RCT Human H₂ therapy Saline / IV

2014 · Takeuchi et al. — Effects of intravenous hydrogen-rich fluid combined with intra-cisternal magnesium sulfate in severe aneurysmal subarachnoid hemorrhage: study protocol for a randomized controlled trial.

BMC neurology
2014 RCT Human H₂ therapy Saline / IV

2014 · Ishibashi et al. — Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study.

International immunopharmacology
2025 Pilot / Observational Human H₂ therapy Inhalation

2025 · Habet et al. — Hydrogen-FAST: Study Protocol for Inhaled Hydrogen Gas as Adjunctive Therapy in Refractory Cardiac Arrest (ECPR)

Trials
2025 Pilot / Observational Human H₂ therapy Drinking (HRW)

2025 · Tu et al. — Immunomodulatory Effects of Molecular Hydrogen Therapy in Systemic Lupus Erythematosus With Pericarditis and Pleuritis: A Case Report

In vivo (Athens, Greece)
2024 Pilot / Observational Human H₂ therapy InhalationDrinking (HRW)

2024 · Lin — Early Hydrogen-Oxygen Gas Mixture Inhalation in Patients with Aneurysmal Subarachnoid Hemorrhage (HOMA): study protocol for a randomized controlled trial.

Trials
2024 Pilot / Observational Human H₂ therapy Inhalation

2024 · Liu — The Benefit of Hydrogen Gas as an Adjunctive Therapy for Chronic Obstructive Pulmonary Disease.

Medicina (Kaunas, Lithuania)
2023 Pilot / Observational Human H₂ therapy TabletsDrinking (HRW)

2023 · Sumbalová — The Effect of Adjuvant Therapy with Molecular Hydrogen on Endogenous Coenzyme Q10 Levels and Platelet Mitochondrial Bioenergetics in Patients with Non-Alcoholic Fatty Liver Disease.

International journal of molecular sciences
2022 Pilot / Observational Human H₂ therapy Bath / Topical

2022 · Tanaka — Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity and inflammation levels in human serum

Medical gas research
2021 Pilot / Observational

2021 · Sugaya — Association of Breath Hydrogen Concentration with Oral Intake and Urinary Diseases

Nihon Hinyokika Gakkai zasshi. The japanese journal of urology
2020 Pilot / Observational Human H₂ therapy Drinking (HRW)

2020 · Asada et al. — Effects of hydrogen-rich water prepared by alternating-current-electrolysis on antioxidant activity, DNA oxidative injuries, and diabetes-related markers.

Medical gas research
2019 Pilot / Observational Human H₂ therapy TabletsDrinking (HRW)

2019 · Javorac et al. — Case Report: Buccal administration of hydrogen-producing blend after a mild traumatic brain injury in a professional athlete.

F1000Research
2019 Pilot / Observational Human H₂ therapy Bath / TopicalDrinking (HRW)

2019 · Asada et al. — Effects of hydrogen-rich water bath on visceral fat and skin blotch, with boiling-resistant hydrogen bubbles.

Medical gas research
2016 Pilot / Observational Human H₂ therapy Inhalation

2016 · Tamura et al. — Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome — First-in-Human Pilot Study.

Circulation journal : official journal of the Japanese Circulation Society
2004 Pilot / Observational

2004 · Nakamura et al. — Bioavailability of Cellobiose by Tolerance Test and Breath Hydrogen Excretion in Humans

Nutrition (Burbank, Los Angeles County, Calif.)
1985 Pilot / Observational

1985 · Solomons et al. — Intestinal Metabolism of a Random-Bonded Polyglucose Bulking Agent in Humans: In Vitro and In Vivo Studies of Hydrogen Evolution

The Journal of laboratory and clinical medicine
2026 Mechanism / Preclinical Drinking (HRW)

2026 · Yang — Molecular hydrogen suppresses gut inflammation and pyroptosis in ulcerative colitis through promoting PKM2 lactylation to block NLRP3 inflammasome activation.

International immunopharmacology
2026 Mechanism / Preclinical Drinking (HRW)

2026 · Yano — Electrolyzed Hydrogen Water Improves Chemosensitivity to Anticancer Drugs by Potently Suppressing Autophagy

Journal of cellular and molecular medicine
2026 Mechanism / Preclinical Unspecified

2026 · Jiao — Therapeutic Potential of Magnesium Diboride Nanosheets in PAH-Associated Right Heart Failure: Integrated Multi-Omics Analysis Reveals Ferroptosis Suppression via LC3/ATG5/NCOA4/FTH1 Pathway

Free radical biology & medicine
2025 Mechanism / Preclinical Drinking (HRW)

2025 · Qiu — 3D printing combined with pH-induced 4D printed iron(III)-oxidized starch gels for controlled iron delivery and enhanced iron supplementation.

Carbohydrate polymers
2025 Mechanism / Preclinical Unspecified

2025 · Chen — A Sustained H₂/Fluorouracil-Releasing Suppository for High-efficacy and Low-Toxicity Hydrogenochemotherapy of Colon Cancer.

Advanced healthcare materials
2025 Mechanism / Preclinical Inhalation

2025 · Zhang — Living Therapeutics for Synergistic Hydrogen-Photothermal Cancer Treatment by Photosynthetic Bacteria.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2023 Mechanism / Preclinical Inhalation

2023 · Son — PdO-Nanoparticle-Embedded Carbon Nanotube Yarns for Wearable Hydrogen Gas Sensing Platforms with Fast and Sensitive Responses

ACS sensors
2023 Mechanism / Preclinical Unspecified

2023 · Zhu — Two-Dimensional Mg₂Si Nanosheet-Enabled Sustained Hydrogen Generation for Improved Repair and Regeneration of Deeply Burned Skin

Advanced healthcare materials
2022 Mechanism / Preclinical Unspecified

2022 · Xiao et al. — Red Tide Short-Time Prediction Using GRU Network Model Based on Multi-Feature Factors: A Case Study in Xiamen Sea Area

Marine environmental research
2022 Mechanism / Preclinical Saline / IV

2022 · Li — Local Treatment of Hydrogen-Rich Saline Promotes Wound Healing In Vivo by Inhibiting Oxidative Stress via Nrf-2/HO-1 Pathway

Oxidative medicine and cellular longevity
2022 Mechanism / Preclinical InhalationSaline / IV

2022 · Ge — Microbial hydrogen economy alleviates colitis by reprogramming colonocyte metabolism and reinforcing intestinal barrier

Gut microbes
2021 Mechanism / Preclinical Unspecified

2021 · Bai et al. — A PdMo Bimetallene with Precise Wavelength Adjustment and Catalysis for Synergistic Photothermal Ablation and Hydrogen Therapy of Cancer at Different Depths

Journal of materials chemistry. B
2021 Mechanism / Preclinical Inhalation

2021 · van Gelder et al. — Safety of Electrooxidation for Urea Removal in a Wearable Artificial Kidney Is Compromised by Formation of Glucose Degradation Products

Artificial organs
2020 Mechanism / Preclinical Unspecified

2020 · Wang — NIR-Driven Water Splitting H₂ Production Nanoplatform for H₂-Mediated Cascade-Amplifying Synergetic Cancer Therapy

ACS applied materials & interfaces
2019 Mechanism / Preclinical Saline / IV

2019 · Kou et al. — Acid-responsive H₂-releasing Fe nanoparticles for safe and effective cancer therapy.

Journal of materials chemistry. B
2019 Mechanism / Preclinical Inhalation

2019 · Kobayashi — Organ Preservation Solution Containing Dissolved Hydrogen Gas from a Hydrogen-Absorbing Alloy Canister Improves Function of Transplanted Ischemic Kidneys in Miniature Pigs

PloS one
2018 Mechanism / Preclinical Unspecified

2018 · Tamaki — Hydrogen Flush After Cold Storage as a New End-Ischemic Ex Vivo Treatment for Liver Grafts Against Ischemia/Reperfusion Injury

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
2018 Mechanism / Preclinical InhalationSaline / IV

2018 · Wan — An In Situ Depot for Continuous Evolution of Gaseous H₂ Mediated by a Magnesium Passivation/Activation Cycle for Treating Osteoarthritis

Angewandte Chemie (International ed. in English)
2016 Mechanism / Preclinical Unspecified

2016 · Davoren — Design and Optimization of Selective Azaindole Amide M1 Positive Allosteric Modulators

Bioorganic & medicinal chemistry letters