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2024 · Khan — Catalytic innovations: Improving wastewater treatment and hydrogen generation technologies.

Nanomaterials as catalysts can both clean wastewater of toxic organic pollutants and simultaneously generate hydrogen gas — a dual benefit reviewed here.

2024 · James et al. — The Synergistic Potential of Hydrogen Inhalation and Hyperbaric Oxygen Therapy

This review article in the Journal of Vascular Surgery examines whether combining hydrogen inhalation with hyperbaric oxygen therapy (HBOT) could produce synergistic therapeutic benefits.

2023 · Wong — A potential clinical application of hydrogen-rich saline in postoperative care

This review article discusses potential clinical uses of hydrogen-rich saline in postoperative care, but no abstract text is publicly available for this record.

2015 · Ohta — Initiation, Development and Potential of Hydrogen Medicine: Toward Therapeutic and Preventive Applications of Molecular Hydrogen Against a Variety of Diseases

This review by Shigeo Ohta — one of the field's founding scientists — traces the history of hydrogen medicine from its 2007 origins, surveys the mechanistic and clinical evidence across multiple disease areas, and outlines future research directions.

2015 · Vogt et al. — Chemical communication in the gut: Effects of microbiota-generated metabolites on gastrointestinal bacterial pathogens.

The gut microbiota does not merely occupy space — it actively shapes the chemical environment of the intestine through metabolites that can inhibit or promote bacterial pathogens.

2015 · Torzillo et al. — Advances in the biotechnology of hydrogen production with the microalga Chlamydomonas reinhardtii.

The green microalga Chlamydomonas reinhardtii can produce hydrogen gas from sunlight and water — a clean energy prospect, but one still far from industrial viability.

2012 · Tran et al. — Proton reduction to hydrogen in biological and chemical systems.

This chemistry review examines the enzymes (hydrogenases) that biological systems use to produce molecular hydrogen (H₂) from protons, and how these natural catalysts inspire the design of synthetic catalysts for solar-energy-driven H₂ production.

2010 · Woods — Computational glycoscience: characterizing the spatial and temporal properties of glycans and glycan-protein complexes.

This review surveys computational methods — molecular dynamics simulations and virtual ligand screening — for studying how sugar chains (glycans) bind to proteins.

2006 · Klemperer — Interstellar chemistry

This theoretical review discusses the molecular chemistry of the interstellar medium, including the role of molecular hydrogen (H₂) and helium ionisation in driving the rich organic chemistry observed in galaxies.

2002 · Nicolet et al. — Fe-only hydrogenases: structure, function and evolution

This biochemistry review covers the molecular structure, catalytic mechanism, and evolutionary origins of iron-only hydrogenase enzymes — proteins that catalyse the reversible conversion between molecular hydrogen (H₂) and protons/electrons.

1999 · Särnblad — Lactose intolerance in children. An analysis of hydrogen gas in exhaled air simplifies and improves diagnosis.

This review article, published in the Swedish medical journal Läkartidningen, discusses the hydrogen breath test as a diagnostic tool for lactose intolerance in children.

1994 · Beglinger — Breath Tests: A Clarification of the Topic

Breath tests measuring either hydrogen gas (H₂) or labeled carbon dioxide (¹³CO₂) in exhaled air represent a non-invasive diagnostic class for gastroenterological evaluation — this review clarifies their main indications and limitations.

1988 · Scrimshaw — The acceptability of milk and milk products in populations with a high prevalence of lactose intolerance.

Most humans lose the ability to digest lactose after infancy — and a standard lactose tolerance test is a poor predictor of whether an individual can actually consume moderate amounts of milk without symptoms.

1988 · Holm — Role of blood flow in gastric acid secretion.

The relationship between blood flow and gastric acid secretion is more complex than long assumed: most measurement methods show no simple proportional link, but there is a critical minimum blood flow below which both oxygen use and acid secretion fall together.

1983 · Ostrander — Breath hydrogen analysis: a review of the methodologies and clinical applications.

Hydrogen gas exhaled in breath — produced when gut bacteria ferment unabsorbed carbohydrates — can serve as a non-invasive clinical tool to detect carbohydrate malabsorption in adults and older children.

2013 · Matsumoto et al. — Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful bladder syndrome.

In a double-blind, placebo-controlled RCT in 30 patients with interstitial cystitis/painful bladder syndrome (IC/PBS), hydrogen-rich water did not significantly outperform placebo on any primary symptom endpoint after 8 weeks — though an exceptional responder rate (11%) was noted.

1998 · Evans — Fructose-sorbitol malabsorption and symptom provocation in irritable bowel syndrome: relationship to enteric hypersensitivity and dysmotility.

In 15 female IBS patients, fructose-sorbitol mixtures provoked symptoms and elevated breath hydrogen in those who malabsorbed the sugars — but symptom severity was not associated with the presence of jejunal hypersensitivity or dysmotility.

1996 · Hertzler et al. — How much lactose is low lactose?

Lactose-intolerant adults tolerated up to 6 g of lactose per serving without significant symptoms, even though fermentation could be detected at that dose by breath hydrogen testing.

1986 · Beck et al. — Comparison of Oral Lavage Methods for Preoperative Colonic Cleansing

A randomised comparison of two bowel preparation methods before colon surgery found that polyethylene glycol electrolyte lavage outperforms 10 % mannitol solution in cleansing quality, patient tolerance, and — critically — safety: mannitol produces combustible hydrogen gas levels in the colon, posing an electrosurgery fire risk.

2023 · Kiyama — Changes in the negative logarithm of end-tidal hydrogen partial pressure indicate the variation of electrode potential in healthy Japanese subjects.

Breath hydrogen, produced by gut bacteria and exhaled in measurable amounts, can serve as a non-invasive window into the body's redox state.

2021 · Haworth — The prevalence of intestinal dysbiosis in patients referred for antireflux surgery

In 104 patients evaluated for antireflux surgery, 60.6% had intestinal dysbiosis — with small intestinal bacterial overgrowth (SIBO) detected by hydrogen breath testing in 39.4% of cases.

2015 · Bae et al. — Determination of rifaximin treatment period according to lactulose breath test values in nonconstipated irritable bowel syndrome subjects.

This retrospective study in 102 IBS patients with confirmed SIBO used lactulose breath test (LBT) H₂ values to determine optimal rifaximin treatment duration (4, 8, or 12 weeks), finding that higher baseline breath H₂ required longer treatment and that symptomatic improvement preceded LBT normalization.

2012 · Ostojic — Serum alkalinization and hydrogen-rich water in healthy men.

This publication investigates serum alkalinization effects of hydrogen-rich water in healthy men. The full abstract was not available in the source data.

2012 · Shimouchi et al. — Estimation of Molecular Hydrogen Consumption in the Human Whole Body after Ingestion of Hydrogen-Rich Water

How much H₂ does the human body actually absorb and consume after drinking hydrogen-rich water?

2008 · Urita et al. — Extensive Atrophic Gastritis Linked to Increased Levels of Intraluminal Hydrogen Gas

This gastroenterology study measures hydrogen gas produced naturally by gut bacteria in 647 patients undergoing upper endoscopy — it is not an H₂ therapy study.

2003 · Terai — Detection of flatus using a portable hydrogen gas analyzer.

A portable hydrogen gas analyzer was used to detect and measure intestinal gas (flatus) in human subjects.

2003 · Oku — Comparison of digestibility and breath hydrogen gas excretion of fructo-oligosaccharide, galactosyl-sucrose, and isomalto-oligosaccharide in healthy human subjects.

Breath hydrogen excretion was used as a diagnostic marker to compare how well three different dietary oligosaccharides (FOS, GS, IMO) are digested in the small intestine versus fermented in the large intestine of healthy adults.

2001 · Goodman — Lactulose-induced pneumatosis intestinalis and pneumoperitoneum.

A 57-year-old patient with colonic inertia developed pneumatosis intestinalis and pneumoperitoneum after lactulose treatment, caused by a build-up of carbon dioxide and hydrogen gas from bacterial fermentation in a setting of altered gut flora.

1988 · Wytock et al. — All Yogurts Are Not Created Equal

Not all yogurt brands are equally effective at helping lactose-intolerant people digest lactose — the key variable is the lactase activity of the bacterial cultures used.

1985 · Hanson et al. — Dietary Fiber Effects on Passage Rate and Breath Hydrogen

This 1985 study measured how different types of dietary fiber affect intestinal transit and the amount of hydrogen gas produced by gut bacteria and measurable in exhaled breath.

1984 · Nishiwaki et al. — Endoscopic Measurement of Gastric Mucosal Blood Flow by Hydrogen Gas Generated by Electrolysis — Comparison with H₂ Inhalation Method

This 1984 study compared two methods for measuring gastric mucosal blood flow during endoscopy: generating H₂ locally via electrolysis versus the conventional inhaled H₂ gas clearance method.

1984 · Hiramatsu et al. — Endoscopical Determination of Gastric Mucosal Blood Flow by the Crossed Thermocouple Method

This 1984 study introduced the crossed thermocouple method as an endoscopic alternative to the hydrogen gas clearance method for measuring gastric mucosal blood flow.

1984 · Dolmans et al. — The Determination of Hydrogen Gas in Expired Air for the Diagnosis of Carbohydrate Resorption Disorders

This 1984 Dutch review article describes breath hydrogen testing as a diagnostic tool for identifying carbohydrate malabsorption disorders — the same principle underlying lactose and fructose intolerance tests used today.

1972 · Sem-Jacobsen — Measurements in man of focal intracerebral blood flow around depth-electrodes with hydrogen gas.

Using depth electrodes and inhaled hydrogen gas as a vascular tracer, researchers measured regional cerebral blood flow directly at specific brain sites in humans.

1969 · Levitt — Production and excretion of hydrogen gas in man.

This study characterised how the human body produces and eliminates hydrogen gas — almost entirely through bacterial fermentation of unabsorbed carbohydrates in the colon — and established hydrogen breath testing as a tool for studying intestinal fermentation.

1969 · Klingenberg — Measurement of human uterine cervical blood flow by local hydrogen gas clearance.

This study measured blood flow in the human uterine cervix using local hydrogen gas clearance — an early attempt to quantify perfusion in a gynaecological tissue that is difficult to assess by other means.

1965 · Heimann — The use of hydrogen inhalation in the detection of intracardiac shunts.

This study evaluated hydrogen inhalation as a diagnostic method for detecting intracardiac shunts in cardiac patients.

1965 · Cosyns — Detection of minimal left-right shunts by hydrogen inhalation.

This study assessed the sensitivity of hydrogen inhalation in detecting minimal (small) left-to-right intracardiac shunts — a clinical challenge where other methods of the era often failed.

1963 · HUGENHOLTZ — The clinical usefulness of hydrogen gas as an indicator of left-to-right shunts.

This study systematically evaluated the clinical utility of hydrogen gas inhalation as an indicator method for detecting left-to-right intracardiac shunts, comparing it with established diagnostic approaches of the era.

2025 · Du — A partially degradable composite consisting of Ti-Zr-Cu-Pd-Sn metallic glass and Fe-Mg alloy for orthopedic applications.

Researchers combined a titanium-based metallic glass with an iron-magnesium alloy into a novel partially degradable bone implant.

2022 · González et al. — Dehydrochlorination of PCDDs on SWCN-Supported Ni₁₀ and Ni₁₃ Clusters: A DFT Study

This computational chemistry study investigates how molecular hydrogen (H₂), assisted by nickel nanoclusters adsorbed on carbon nanotubes, can chemically break down polychlorinated dibenzo-p-dioxins (PCDDs) — one of the most toxic classes of environmental pollutants.

2022 · Yamamoto et al. — Development of a Model System for Gas Cavity Formation Behavior of Magnesium Alloy Implantation

This study developed an in-vitro gelatin model to simulate and measure the hydrogen gas cavities that form in tissue when biodegradable magnesium (Mg) bone screws corrode — a known clinical challenge in orthopaedic surgery.

2022 · Bulut — Hydrogen-rich water can reduce the formation of biogenic amines in butter

Washing raw butter with hydrogen-rich water — prepared either by bubbling hydrogen gas or by adding magnesium — significantly reduced the formation of biogenic amines (including histamine, tryptamine, and spermidine) during 90 days of storage.

2022 · Wang — Regulation of chlorothalonil degradation by molecular hydrogen

This in-vitro and plant study shows that molecular hydrogen accelerates the breakdown of the fungicide chlorothalonil in several crop plants — including tomato, rice, and cabbage — without reducing the pesticide's antifungal effectiveness.

2021 · Hartjen — Toward Tailoring the Degradation Rate of Magnesium-Based Biomaterials for Various Medical Applications: Assessing Corrosion, Cytocompatibility and Immunological Effects

This in-vitro materials science study tested a surface-treated magnesium alloy (WE43 with plasma electrolytic oxidation) as a degradable implant material.

2021 · Duffner — Dechloromonas and close relatives prevail during hydrogenotrophic denitrification in stimulated microcosms with oxic aquifer material

When hydrogen gas was added to groundwater microcosms contaminated with nitrate, a specific genus of bacteria (Dechloromonas) dominated the resulting nitrate-removal community.

2020 · Ichikawa et al. — Proposal of next-generation medical care „Mega-hydrogen Therapy”

This theoretical paper proposes the concept of „Mega-hydrogen Therapy” — delivering unusually high doses of molecular hydrogen (H₂) — as a next-generation medical approach.

2020 · Murugesan et al. — Catalytic reductive aminations using molecular hydrogen for synthesis of different kinds of amines

This is an organic chemistry review on industrial and pharmaceutical amine synthesis using molecular hydrogen as a reducing agent — it has no connection to hydrogen therapy or medical use of H₂ in the human body.

2019 · Herdendorf — Staphylococcus aureus Evasion Proteins EapH1 and EapH2: Residue-Level Investigation of an Alternative Binding Motif for Human Neutrophil Elastase

Two bacterial immune-evasion proteins (EapH1 and EapH2) from Staphylococcus aureus inhibit a key human immune enzyme — neutrophil elastase — but use structurally different binding strategies.

2019 · Jung — In Vivo Simulation of Magnesium Degradability Using a New Fluid Dynamic Bench Testing Approach

A new dynamic test bench was constructed to measure hydrogen gas (H₂) release during the degradation of magnesium-based implants — using H₂ evolution as a proxy for degradation rate under physiological conditions.

2019 · Schmidt — Lifetime of Parahydrogen in Aqueous Solutions and Human Blood

Parahydrogen (pH₂) — a nuclear spin isomer of molecular hydrogen — survives for unexpectedly long periods in water and even in human blood, with lifetimes of 10 to 300 minutes.

2019 · Moon — Different Molecular Interaction between Collagen and α- or β-Chitin in Mechanically Improved Electrospun Composite

Electrospun composite fibres combining collagen with β-chitin showed 41% higher tensile strength than pure collagen and 14% better than α-chitin composites, due to favourable inter-molecular hydrogen bonds between β-chitin and collagen.

2018 · Karunakaran — A molecular dynamics approach to explore the structural characterisation of cataract causing mutation R58H on human γD crystallin

Using molecular dynamics simulations, researchers modelled how the R58H mutation in γD-crystallin — a lens protein — promotes protein misfolding and aggregation, potentially causing cataract.

2017 · Ben Hassen Trabelsi — Hydrogen-Rich Syngas Production from Gasification and Pyrolysis of Solar Dried Sewage Sludge: Experimental and Modelling Investigations

Researchers converted solar-dried sewage sludge into hydrogen-rich synthesis gas (syngas) using pyrolysis and gasification, achieving H₂ contents up to 11 wt% in pyrolysis gas.

2017 · Asanuma — Translational Study of Hydrogen Gas Inhalation as Adjuncts to Reperfusion Therapy for Acute Myocardial Infarction

This translational study investigated hydrogen gas inhalation as an add-on to reperfusion therapy in acute myocardial infarction — bridging animal and early clinical research.

2017 · Ostojic — Non-Gut Microbiota as a Source of Bioactive Hydrogen

This theoretical paper proposes that hydrogen-producing microorganisms outside the gastrointestinal tract — for example in the oral cavity, skin, or urogenital system — may contribute to the body's endogenous H₂ supply.

2017 · Rigdon — Evaluation of Alkaline Electrolyzed Water to Replace Traditional Phosphate Enhancement Solutions: Effects on Water Holding Capacity, Tenderness, and Sensory Characteristics

Alkaline electrolyzed water was tested as a potential replacement for industrial phosphate-based pork enhancement solutions, and it performed worse: pork chops treated with alkaline electrolyzed water lost more moisture, and there was no improvement in tenderness or sensory qualities compared with the industry standard.

2016 · Lipinski — Rule of Five in 2015 and Beyond: Target and Ligand Structural Limitations, Ligand Chemistry Structure and Drug Discovery Project Decisions

This paper by the creator of the famous „Rule of Five“ (Ro5) re-examines the physicochemical limits of oral drug molecules and discusses how natural products — with their intramolecular hydrogen bonds — create exceptions to these rules.

2016 · Coplen — A revision in hydrogen isotopic composition of USGS42 and USGS43 human-hair stable isotopic reference materials for forensic science

This analytical chemistry paper revises the certified hydrogen isotope values of two international reference materials (USGS42 and USGS43) made from human hair, used in forensic stable isotope analysis.

2016 · Zhao — Dock 'n roll: folding of a silk-inspired polypeptide into an amyloid-like beta solenoid

This computational chemistry and molecular dynamics study analyses how a silk-inspired polypeptide folds into a stable beta-solenoid structure — a question in structural biology and materials science.

2016 · Ostojic — Is Melanin a Source of Bioactive Molecular Hydrogen?

This theoretical paper proposes that melanin — the pigment in human skin, hair, and eyes — may act as a natural biological source of molecular hydrogen (H₂) in the body.

2016 · Chetty — Multi-Drug Resistance Profile of PR20 HIV-1 Protease Is Attributed to Distorted Conformational and Drug Binding Landscape: Molecular Dynamics Insights

This computational chemistry study analyzed how 20 mutations in the HIV-1 protease (PR20 variant) distort its structure and reduce drug binding, explaining the high multi-drug resistance of this variant.

2015 · Bhakat — Effect of T68A/N126Y mutations on the conformational and ligand binding landscape of Coxsackievirus B3 3C protease.

Computational modelling reveals how two point mutations in the Coxsackievirus B3 (CVB3) 3C protease weaken the enzyme's grip on its antiviral inhibitor — a structural basis for drug resistance.

2015 · Bharty et al. — Synthesis, spectral characterization, thermal behaviour, antibacterial activity and DFT calculation on N'-[bis(methylsulfanyl)methylene]-2-hydroxybenzohydrazide and N'-(4-methoxybenzoyl)-hydrazinecarbodithioic acid ethyl ester.

Two new synthetic compounds based on hydrazone scaffolds were characterised by X-ray crystallography, NMR, IR, and thermal analysis; both showed antibacterial activity and nonlinear optical (NLO) properties superior to urea.

2015 · Oda et al. — Prediction of binding modes between protein L-isoaspartyl (D-aspartyl) O-methyltransferase and peptide substrates including isomerized aspartic acid residues using in silico analytic methods for the substrate screening.

Computational docking and molecular dynamics simulation successfully predicted how the DNA-repair enzyme PIMT recognises isomerised aspartic acid variants in peptide substrates — distinguishing true substrates from non-substrates purely in silico.

2015 · Keles et al. — Can an innocent toy become dangerous? The hydrogen gas balloon burn.

Hydrogen gas, used to fill balloons, can ignite and cause severe burns — a safety risk that is rarely discussed.

2015 · Casanova et al. — Campylobacter concisus pseudo-outbreak caused by improved culture conditions.

A hospital in Bern noticed a sudden rise in Campylobacter concisus detections — but it turned out to be a pseudo-outbreak caused by switching to a hydrogen-enriched atmosphere in the lab, which made the bacterium grow far better.

2014 · Chen — Controlling initial biodegradation of magnesium by a biocompatible strontium phosphate conversion coating

Magnesium implants dissolve too quickly after implantation — a strontium phosphate (SrP) coating developed in this in-vitro study significantly slows this degradation.

2012 · Wang et al. — Binding hot-spots in an antibody-ssDNA interface: a molecular dynamics study.

This computational biology study used molecular dynamics simulations to identify key amino acid residues that stabilise the interaction between a lupus-associated antibody and single-stranded DNA (ssDNA).

2012 · Hopper et al. — Evidence for the preservation of native inter- and intra-molecular hydrogen bonds in the desolvated FK-binding protein·FK506 complex produced by electrospray ionization.

This biophysical study used mass spectrometry and ion mobility spectrometry to investigate whether protein-ligand hydrogen bonds are preserved when protein complexes are transferred from solution into the gas phase by electrospray ionisation.

2011 · Schneider — The Trichomonas vaginalis Hydrogenosome Proteome Is Highly Reduced Relative to Mitochondria, Yet Complex Compared with Mitosomes

This cell-biology study maps the full protein inventory of the hydrogenosome — a molecular-hydrogen-producing organelle in the human parasite Trichomonas vaginalis — revealing 569 proteins, far fewer than mitochondria but far more than the most stripped-down mitochondria-related organelles.

2011 · Gao — Fabrication and Characterization of Bioactive Composite Coatings on Mg-Zn-Ca Alloy by MAO/Sol-Gel

This in-vitro materials science study develops a two-layer protective coating for magnesium alloy implants that dramatically reduces corrosion and supports cell adhesion — addressing one of the main obstacles to using biodegradable magnesium in medical implants, namely the rapid release of hydrogen gas during degradation.

2011 · Liu — Quinazolines with Intra-Molecular Hydrogen Bonding Scaffold (iMHBS) as PI3K/mTOR Dual Inhibitors

This medicinal chemistry study designs and synthesises a series of quinazoline molecules that use intra-molecular hydrogen bonding to form a pseudo-ring structure, acting as potent dual inhibitors of PI3K and mTOR — two kinases central to cancer cell proliferation and survival.

2011 · Chai — Perfusion Electrodeposition of Calcium Phosphate on Additive Manufactured Titanium Scaffolds for Bone Engineering

This biomaterials engineering study develops a perfusion-based electrodeposition system to uniformly coat 3D-printed titanium bone scaffolds with hydroxyapatite — a calcium phosphate mineral that promotes bone cell adhesion and growth — while addressing hydrogen gas removal as a technical process challenge.

2010 · Bolca — Microbial equol production attenuates colonic methanogenesis and sulphidogenesis in vitro.

This in-vitro gut microbiology study showed that equol-producing bacteria — which consume H₂ gas as part of converting the soy isoflavone daidzein into equol — competitively reduce methane and hydrogen sulphide production in the colon.

2008 · Kniess et al. — Practical experiences with the synthesis of [¹¹C]CH₃I through gas phase iodination using a TRACERlabFXC synthesis module

This in-vitro chemistry study optimises the synthesis of the radiotracer [¹¹C]CH₃I — a carbon-11-labelled compound used in PET imaging — by testing several nickel catalysts for the intermediate hydrogen-reduction step.

2005 · Decroos et al. — Isolation and characterisation of an equol-producing mixed microbial culture from a human faecal sample and its activity under gastrointestinal conditions

This in-vitro gut microbiome study shows that hydrogen gas produced during gut fermentation stimulates equol production by a mixed bacterial culture derived from human stool.

2002 · Avvakumov et al. — Crystal structure of human sex hormone-binding globulin in complex with 2-methoxyestradiol reveals the molecular basis for high affinity interactions with C-2 derivatives of estradiol

This in-vitro structural biology study resolves the crystal structure of human sex hormone-binding globulin (SHBG) bound to 2-methoxyestradiol, explaining at the atomic level why certain estradiol derivatives bind with high or low affinity.

2002 · Peterson — Tritium doses from chronic atmospheric releases: a new approach proposed for regulatory compliance.

This theoretical modelling study proposes an improved regulatory model (NEWTRIT) for calculating human doses from atmospheric tritium releases — including tritiated hydrogen gas (HT) and organically bound tritium in food.

2000 · Pletnev — Crystal structure of bovine duodenase, a serine protease, with dual trypsin and chymotrypsin-like specificities.

This in-vitro structural study resolves the three-dimensional crystal structure of duodenase, a serine protease from bovine duodenum, at 2.4 Å resolution.

1999 · Nakayama — CTAB-mediated enrichment for active forms of novel dimeric maxizymes.

This in-vitro study shows that the cationic detergent CTAB dramatically enhances the activity of dimeric ribozymes called maxizymes, by promoting the conversion of inactive conformations into active forms.

1995 · Gillespie — Energetics of Molecular Hydrogen Oxidation in the Oral Pathogen Campylobacter rectus

This in-vitro study examined how the oral pathogen Campylobacter rectus oxidizes molecular hydrogen (H₂) as an energy source — a fundamental microbiology question about bacterial hydrogen metabolism in the oral cavity.

1994 · Chakravarty — Drug–Protein Interactions: Refined Structures of Three Sulfonamide Drug Complexes of Human Carbonic Anhydrase I Enzyme

This in-vitro crystallography study resolved the atomic structures of three sulfonamide drugs bound to human carbonic anhydrase I (HCAI) at 2 Å resolution, revealing how hydrogen bonds within the enzyme's active site determine inhibitor orientation and potency.

1992 · McGown — Regeneration of Functional Hemoglobin from Iron(III) Hemoglobin by Reduction with Hydrogen and a Heterogeneous Catalyst

1992 · Ellies — Crystallographic Changes in Calcium Phosphates During Plasma-Spraying

This in-vitro materials science study examined how plasma-spraying calcium phosphate powders — using hydrogen gas as part of the plasma torch process — causes crystallographic transformations, converting some hydroxyapatite (HA) to more-resorbable beta-tricalcium phosphate (β-TCP) and calcium oxide.

1992 · Wong — A New Zinc Product for the Reduction of Water in Physiological Fluids to Hydrogen Gas for ²H/¹H Isotope Ratio Measurements

This methodological study describes a new zinc-based reagent for converting water in physiological fluids to hydrogen gas for deuterium/hydrogen (²H/¹H) isotope ratio analysis — enabling accurate, convenient measurement of total body water and metabolic turnover rates in nutritional research.

1991 · Kawano — Protective Effect of Rebamipide (OPC-12759) on the Gastric Mucosa in Rats and Humans

This combined animal and small human study showed that rebamipide — a gastric mucosal protective drug — prevents HCl-ethanol-induced gastric lesions in rats dose-dependently and significantly inhibits mucosal damage in healthy human volunteers, partly by improving mucosal microcirculation as measured by hydrogen gas clearance.

1990 · Gibson — Alternative pathways for hydrogen disposal during fermentation in the human colon.

When gut bacteria ferment carbohydrates, they produce hydrogen gas that must be disposed of — and the colon has several competing routes for doing so.

1986 · Sato — Hemodynamics of the gastric mucosa and gastric ulceration in rats and in patients with gastric ulcer.

A spectrophotometric method for non-invasive assessment of gastric mucosal oxygen supply was validated against hydrogen gas clearance and other blood flow techniques, and applied to study how microcirculation affects ulcer formation in rat stress models and ulcer healing in human patients.

1982 · Murakami — Contact electrode method in hydrogen gas clearance technique: a new method for determination of regional gastric mucosal blood flow in animals and humans.

A new contact electrode method for hydrogen gas clearance was developed to measure regional gastric mucosal blood flow non-destructively, tested in both animal models and human subjects.

1976 · Harding — Characterization of Bacteroides melaninogenicus.

Fifty-eight human isolates of Bacteroides melaninogenicus were systematically classified into three subspecies using seven biochemical characteristics.

1947 · FARKAS — On the activation of molecular hydrogen by Proteus vulgaris.

This 1947 paper investigated how the bacterium Proteus vulgaris activates molecular hydrogen (H₂) — an early study in microbial hydrogen metabolism. No abstract is available for this historical publication.