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Skin & Aging

Skin, wound healing and ageing, where H₂ is studied mainly through oxidative stress.

Human studies on molecular hydrogen for Skin & Aging. This page collects the 102 studies catalogued in this area — 3 randomized trials, 30 pilot/observational studies and 26 reviews. Listed newest first.

2026 Review / Meta-analysis Inhalation

2026 · Nguyen Puente — Emerging Clinical Applications for Molecular Hydrogen

Respiratory care
2026 Review / Meta-analysis InhalationSaline / IVDrinking (HRW)

2026 · Nguyen — Advances in hydrogen delivery strategies for therapeutic applications

Advanced drug delivery reviews
2026 Review / Meta-analysis Inhalation

2026 · Pan — Stimuli-Responsive Hydrogen Production from Nanomaterials: Design, Regulation and Biomedical Applications

Advanced healthcare materials
2025 Review / Meta-analysis Unspecified

2025 · Xie — Mechanisms and Protective Strategies for Astronaut Skin Injury in Deep Space Environments

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
2025 Review / Meta-analysis Unspecified

2025 · Li — Delivery of Molecular Hydrogen for Precision Immunomodulation: Mechanisms, Detection Methods, and Applications

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2025 Review / Meta-analysis Unspecified

2025 · Brandi — Molecular hydrogen therapy: A „democratic” emerging strategy against aging and age-related diseases

Ageing research reviews
2025 Review / Meta-analysis Drinking (HRW)

2025 · Bjørklund — Advanced Glycation End Products and Skin Autoimmune Disorders: Pathogenic Insights into Vitiligo, Bullous Pemphigoid, and Type 1 Diabetes Mellitus

Current medicinal chemistry
2025 Review / Meta-analysis Unspecified

2025 · Sahu — Activation, interaction and intimation of Nrf2 pathway and their mutational studies causing Nrf2 associated cancer

Biochimica et biophysica acta. Molecular basis of disease
2025 Review / Meta-analysis Drinking (HRW)

2025 · Alaqel — Aging, vascular dysfunction, and the blood-brain barrier: unveiling the pathophysiology of stroke in older adults

Biogerontology
2025 Review / Meta-analysis Inhalation

2025 · Zamanian — The Roles of Neuroinflammation in l-DOPA-Induced Dyskinesia: Dissecting the Roles of NF-κB and TNF-α for Novel Pharmacological Therapeutic Approaches

The European journal of neuroscience
2025 Review / Meta-analysis Inhalation

2025 · Li — Application Trends of Hydrogen-generating Nanomaterials for the Treatment of ROS-related Diseases

Biomaterials science
2024 Review / Meta-analysis Drinking (HRW)

2024 · Dhillon — Hydrogen Water: Extra Healthy or a Hoax?—A Systematic Review

International Journal of Molecular Sciences
2024 Review / Meta-analysis Unspecified

2024 · Slezák — New Possibilities of the Prevention and Treatment of Cardiovascular Pathologies: The Potential of Molecular Hydrogen in the Reduction of Oxidative Stress

Physiological research
2024 Review / Meta-analysis Unspecified

2024 · Zheng — Potential Role of Molecular Hydrogen Therapy on Oxidative Stress and Redox Signaling in Chronic Kidney Disease

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
2024 Review / Meta-analysis Inhalation

2024 · Afkhami — Exploring Approaches to Pulp Vitality Assessment: A Scoping Review of Nontraditional Methods

International endodontic journal
2022 Review / Meta-analysis Drinking (HRW)

2022 · Lippi — Impact of nutraceuticals and dietary supplements on mitochondria modifications in healthy aging: a systematic review of randomized controlled trials

Aging clinical and experimental research
2022 Review / Meta-analysis Unspecified

2022 · Fu — Molecular hydrogen is a promising therapeutic agent for pulmonary disease

Journal of Zhejiang University. Science. B
2021 Review / Meta-analysis Unspecified

2021 · Bajgai et al. — Role of Molecular Hydrogen in Skin Diseases and its Impact in Beauty.

Current pharmaceutical design
2021 Review / Meta-analysis Unspecified

2021 · Slezak et al. — Oxidative Stress and Pathways of Molecular Hydrogen Effects in Medicine

Current pharmaceutical design
2016 Review / Meta-analysis Unspecified

2016 · Zheng — Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis

Oxidative medicine and cellular longevity
2015 Review / Meta-analysis Inhalation

2015 · Shimura et al. — Radiation occupational health interventions offered to radiation workers in response to the complex catastrophic disaster at the Fukushima Daiichi Nuclear Power Plant.

Journal of radiation research
2013 Review / Meta-analysis Unspecified

2013 · Wang — Introspection of oxidant/antioxidant imbalance in the inner ear

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery
2013 Review / Meta-analysis Saline / IVDrinking (HRW)

2013 · Qian — Hydrogen as a new class of radioprotective agent

International journal of biological sciences
2012 Review / Meta-analysis InhalationSaline / IVBath / TopicalDrinking (HRW)

2012 · Ohta — Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases.

Biochimica et biophysica acta
2011 Review / Meta-analysis InhalationSaline / IVBath / TopicalDrinking (HRW)

2011 · Ohta — Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications.

Current pharmaceutical design
1996 Review / Meta-analysis Unspecified

1996 · Mehta — Magnetization Transfer Magnetic Resonance Imaging: A Clinical Review

Topics in magnetic resonance imaging : TMRI
2026 RCT Human H₂ therapy Drinking (HRW)

2026 · Kuang — Exploratory Evaluation of Hydrogen-Rich Water Therapy for Keloid Management: A Double-Blinded Randomized Pilot Trial

Aesthetic Plastic Surgery
2021 RCT Human H₂ therapy Drinking (HRW)

2021 · Zanini — The effects of 6-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in older adults aged 70 years and over: A randomized controlled pilot trial

Experimental Gerontology
2017 RCT Human H₂ therapy InhalationSaline / IV

2017 · Ono et al. — Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
2026 Pilot / Observational Human H₂ therapy Saline / IV

2026 · Xu et al. — Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via Promoting Mitophagy

Journal of diabetes
2025 Pilot / Observational Human H₂ therapy Drinking (HRW)

2025 · Ren et al. — A Case Report of Adjuvant Molecular Hydrogen Therapy in Refractory Rheumatoid Arthritis With Atlantoaxial Subluxation

In vivo (Athens, Greece)
2025 Pilot / Observational Human H₂ therapy Drinking (HRW)

2025 · Wong et al. — Nano-Bubble Hydrogen Water in Wet-Wrap Dressing Improves the Severity of Pediatric Patients With Atopic Dermatitis

Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners
2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Tsai et al. — Molecular Hydrogen as an Adjuvant Therapy in Comorbid Sjögren's Syndrome, SLE, and ILD: A Case Report on Immune Modulation and Fatigue Reduction

In vivo (Athens, Greece)
2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Lin et al. — Molecular Hydrogen Capsule Therapy for Primary Biliary Cholangitis With Elevated IgG4: A Case Report on Immune Marker Normalization

In vivo (Athens, Greece)
2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Hsu et al. — Molecular Hydrogen Therapy Enhances Immune Markers in Treg, Plasma, Tr1 Cells, and KLRG1 Expression on Tc Cells: A Case of Acute SDH With Midline Shift and Uncal Herniation Post-decompressive Craniectomy

In vivo (Athens, Greece)
2025 Pilot / Observational Human H₂ therapy Saline / IV

2025 · Kuang et al. — Hydrogen-Rich Saline Combined With Vacuum Sealing Drainage Promotes Wound Healing by Altering Biotin Metabolism

Journal of cellular and molecular medicine
2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Lin et al. — Molecular Hydrogen as a Potential Adjunctive Therapy to Improve Renal Function and Reduce Fatigue in an Elderly Patient With Chronic Comorbidities: A Case Report

In vivo (Athens, Greece)
2024 Pilot / Observational Human H₂ therapy Drinking (HRW)

2024 · Chen — Molecular Hydrogen Therapy in Aneurysmal SAH With RA and Newly-diagnosed SLE, Complicated With Acute Ischemic Infarction: A Case Report of Improved Immune Markers Including Tr1 Cells, Breg Cells and TIM3 Expression on Tc Cells.

In vivo (Athens, Greece)
2024 Pilot / Observational Human H₂ therapy Unspecified

2024 · Lin — Molecular Hydrogen Therapy in Sjögren's Syndrome With Pulmonary Arterial Hypertension and Right-sided Heart Failure: A Case Report of Improved Immune Markers Including Treg, B Cells and Plasma Cell.

In vivo (Athens, Greece)
2024 Pilot / Observational Human H₂ therapy InhalationDrinking (HRW)

2024 · Lin — Early Hydrogen-Oxygen Gas Mixture Inhalation in Patients with Aneurysmal Subarachnoid Hemorrhage (HOMA): study protocol for a randomized controlled trial.

Trials
2024 Pilot / Observational Human H₂ therapy Unspecified

2024 · Lui — Molecular Hydrogen as a Promising Therapy Could Be Linked With Increased Resting Treg Cells or Decreased Fas+ T Cell Subsets in a IgG4-PF-ILD Patient: A Case Report.

In vivo (Athens, Greece)
2024 Pilot / Observational Human H₂ therapy Drinking (HRW)

2024 · Guan — Successful treatment of Behçet's disease ulcers and skin lesions with hydrogen water.

International journal of dermatology
2022 Pilot / Observational Human H₂ therapy Bath / Topical

2022 · Tanaka — Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity and inflammation levels in human serum

Medical gas research
2021 Pilot / Observational Human H₂ therapy Bath / TopicalDrinking (HRW)

2021 · Kato — Heat-retention effects of hydrogen-rich water bath assessed by thermography for humans

Journal of Thermal Biology
2021 Pilot / Observational Human H₂ therapy Drinking (HRW)

2021 · Kubota — Randomized, crossover clinical efficacy trial in humans and mice on tear secretion promotion and lacrimal gland protection by molecular hydrogen

Scientific Reports
2021 Pilot / Observational

2021 · Sugaya — Association of Breath Hydrogen Concentration with Oral Intake and Urinary Diseases

Nihon Hinyokika Gakkai zasshi. The japanese journal of urology
2020 Pilot / Observational Human H₂ therapy Drinking (HRW)

2020 · Asada et al. — Effects of hydrogen-rich water prepared by alternating-current-electrolysis on antioxidant activity, DNA oxidative injuries, and diabetes-related markers.

Medical gas research
2019 Pilot / Observational Human H₂ therapy Inhalation

2019 · Chen et al. — „Real world survey“ of hydrogen-controlled cancer: a follow-up report of 82 advanced cancer patients.

Medical gas research
2019 Pilot / Observational Human H₂ therapy Drinking (HRW)

2019 · Yang et al. — Skin ulcers infected with conditional pathogenic strains treated with local hydrogen water packing in two pemphigus vulgaris patients: Case reports with follow-up for 2 months.

Dermatologic therapy
2019 Pilot / Observational Human H₂ therapy Bath / TopicalDrinking (HRW)

2019 · Asada et al. — Effects of hydrogen-rich water bath on visceral fat and skin blotch, with boiling-resistant hydrogen bubbles.

Medical gas research
2018 Pilot / Observational Human H₂ therapy Bath / TopicalDrinking (HRW)

2018 · Zhu — Positive Effects of Hydrogen-Water Bathing in Patients of Psoriasis and Parapsoriasis en Plaques

Scientific reports
2017 Pilot / Observational Human H₂ therapy Saline / IV

2017 · Qian et al. — Therapeutic effects of hydrogen on chronic graft-versus-host disease.

Journal of cellular and molecular medicine
2017 Pilot / Observational Human H₂ therapy Inhalation

2017 · Katsumata et al. — The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction — First Pilot Study in Humans.

Circulation journal : official journal of the Japanese Circulation Society
2015 Pilot / Observational Human H₂ therapy InhalationSaline / IVDrinking (HRW)

2015 · Ishibashi et al. — Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases.

Molecular medicine reports
2011 Pilot / Observational

2011 · Tsushima et al. — Feasibility of Measuring Human Pancreatic Perfusion In Vivo Using Imaging Techniques

Pancreas
2000 Pilot / Observational

2000 · Pribila — Improved lactose digestion and intolerance among African-American adolescent girls fed a dairy-rich diet.

Journal of the American Dietetic Association
1995 Pilot / Observational

1995 · Hundley et al. — Assessment of left-to-right intracardiac shunting by velocity-encoded, phase-difference magnetic resonance imaging

Circulation
1988 Pilot / Observational

1988 · Neale — Dietary Fibre and Health: The Role of Hydrogen Production

Medical hypotheses
1986 Pilot / Observational

1986 · Nohara et al. — Measurement of Skin Blood Flow Using Inhaled Hydrogen Gas Clearance Method

Kokyu to junkan. Respiration & circulation
2026 Mechanism / Preclinical Inhalation

2026 · Zhao — Molecular hydrogen triggers TRPC4-TRPC4AP-dependent reversible calcium transients via extracellular influx

Theranostics
2026 Mechanism / Preclinical Inhalation

2026 · Kiyoi — Transcriptome-Based Evaluation of Hydrogen Gas Effects for Preventing UVA-Induced Photoaging Using an Artificial Skin Model

Geriatrics & gerontology international
2026 Mechanism / Preclinical Inhalation

2026 · Li — MXene-Engineered MgB₂ Nanoprodrugs with Acid-Responsive Hydrogen Evolution for Cooperative Photothermal Cancer Ablation

ACS applied materials & interfaces
2026 Mechanism / Preclinical Drinking (HRW)

2026 · Wu — Hydrogen Ameliorates Psoriasis-Like Skin Inflammation via Inhibiting the cGAS-STING Pathway

Clinical and experimental immunology
2025 Mechanism / Preclinical Bath / Topical

2025 · Zhu — Transdermal Hydrogen Therapy for Psoriasis Using Cavity-embedded Double-conical Microneedles

Journal of controlled release : official journal of the Controlled Release Society
2025 Mechanism / Preclinical Inhalation

2025 · Wang — Spontaneous Hydrogen-releasing Nanoenzyme Alleviates Osteoarthritis via Oxidative Stress Reduction and Mitochondrial Dysfunction Reversal

Journal of nanobiotechnology
2025 Mechanism / Preclinical Inhalation

2025 · Wang — Hierarchical ROS-scavenging platform breaks vicious cycle of stem cell senescence, angiogenesis arrest, and immune dysregulation in diabetic wounds.

Journal of controlled release : official journal of the Controlled Release Society
2025 Mechanism / Preclinical Inhalation

2025 · Zhang — Hydrogen attenuates the senescence of adipose-derived stem cells and enhances their myogenic differentiation via modulation of the PRDX6/SIRT1/PGC-1α signaling pathway.

Human & experimental toxicology
2025 Mechanism / Preclinical Unspecified

2025 · Li — Hydrogen promoted mitochondrial autophagy and alleviated CIH-induced vascular endothelial cell senescence by regulating oxidative stress.

European journal of pharmacology
2025 Mechanism / Preclinical Inhalation

2025 · Lin — Galvanic Cell Bipolar Microneedle Patches for Reversing Photoaging Wrinkles.

Advanced materials (Deerfield Beach, Fla.)
2025 Mechanism / Preclinical Unspecified

2025 · Yu — Protective Effects of Hydrogen Treatment Against High Glucose-Induced Oxidative Stress and Apoptosis via Inhibition of the AGEs/RAGE/NF-κB Signaling Pathway in Skin Cells.

Endocrine, metabolic & immune disorders drug targets
2024 Mechanism / Preclinical Inhalation

2024 · Tumurbaatar — The effect of hydrogen gas on the oxidative stress response in adipose tissue.

Scientific reports
2024 Mechanism / Preclinical Unspecified

2024 · Xu — Poly(ionic liquid)-Flocculated Chlorella Loading Bactericidal and Antioxidant Hydrogel as a Biological Hydrogen Therapy for Diabetic Wound Dressing.

ACS applied materials & interfaces
2024 Mechanism / Preclinical Drinking (HRW)

2024 · Wang — Combined use of hydrogen-rich water and enzyme-digested edible bird's nest improves PMA/LPS-impaired wound healing in human inflammatory gingival tissue equivalents.

Human cell
2024 Mechanism / Preclinical Inhalation

2024 · Chen et al. — Endogenous Melanin and Hydrogen-Based Specific Activated Theranostics Nanoagents: A Novel Multi-Treatment Paradigm for Rheumatoid Arthritis

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2023 Mechanism / Preclinical Unspecified

2023 · Agar — The Inhibition Mechanism of Pancreatic Ductal Adenocarcinoma via LXR Receptors: A Multifaceted Approach Integrating Molecular Docking, Molecular Dynamics and Post-MD Inter-Molecular Contact Analysis

Asian Pacific journal of cancer prevention : APJCP
2023 Mechanism / Preclinical InhalationSaline / IV

2023 · Aokage — Attenuation of pulmonary damage in aged lipopolysaccharide-induced inflammation mice through continuous 2 % hydrogen gas inhalation: A potential therapeutic strategy for geriatric inflammation and survival

Experimental gerontology
2023 Mechanism / Preclinical Inhalation

2023 · Kiyoi — Intermittent environmental exposure to hydrogen prevents skin photoaging through reduction of oxidative stress

Geriatrics & gerontology international
2023 Mechanism / Preclinical Unspecified

2023 · Wang — pH-Responsive Delivery of H₂ through Ammonia Borane-Loaded Hollow Polydopamine for Intervertebral Disc Degeneration Therapy

Oxidative medicine and cellular longevity
2023 Mechanism / Preclinical Unspecified

2023 · Zhu — Two-Dimensional Mg₂Si Nanosheet-Enabled Sustained Hydrogen Generation for Improved Repair and Regeneration of Deeply Burned Skin

Advanced healthcare materials
2023 Mechanism / Preclinical Bath / Topical

2023 · Sahoo — Hydrogen-producing Photocatalyst at Sunscreen for Athletes in Preventing and Healing Muscle-nerve-skin Injuries

Current topics in medicinal chemistry
2023 Mechanism / Preclinical Unspecified

2023 · Yang — Molecular Hydrogen Promotes Adipose-derived Stem Cell Myogenic Differentiation via Regulation of Mitochondria

Current stem cell research & therapy
2022 Mechanism / Preclinical Bath / TopicalDrinking (HRW)

2022 · Chen et al. — Photocatalytic Glucose Depletion and Hydrogen Generation for Diabetic Wound Healing

Nature communications
2022 Mechanism / Preclinical Saline / IV

2022 · Li — Local Treatment of Hydrogen-Rich Saline Promotes Wound Healing In Vivo by Inhibiting Oxidative Stress via Nrf-2/HO-1 Pathway

Oxidative medicine and cellular longevity
2022 Mechanism / Preclinical Drinking (HRW)

2022 · Mizutani — Hydrogen-rich water reduced oxidative stress and renal fibrosis in rats with unilateral ureteral obstruction.

Pediatric research
2021 Mechanism / Preclinical Inhalation

2021 · Yuan et al. — In Situ Hydrogen Nanogenerator for Bimodal Imaging Guided Synergistic Photothermal/Hydrogen Therapies

Nanoscale
2020 Mechanism / Preclinical Drinking (HRW)

2020 · Kwon — Antioxidant Activity of Hydrogen Water Mask Pack Composed of Gel-Type Emulsion and Hydrogen Generation Powder

International journal of molecular sciences
2020 Mechanism / Preclinical Inhalation

2020 · Echeverry-Rendon — Interaction of Different Cell Types with Magnesium Modified by Plasma Electrolytic Oxidation

Colloids and surfaces. B, Biointerfaces
2020 Mechanism / Preclinical Inhalation

2020 · Meng — Hydrogen Gas Represses the Progression of Lung Cancer via Down-regulating CD47

Bioscience reports
2019 Mechanism / Preclinical Saline / IV

2019 · Kou et al. — Acid-responsive H₂-releasing Fe nanoparticles for safe and effective cancer therapy.

Journal of materials chemistry. B
2019 Mechanism / Preclinical Inhalation

2019 · Liu — Molecular Hydrogen Suppresses Glioblastoma Growth via Inducing the Glioma Stem-Like Cell Differentiation

Stem cell research & therapy
2018 Mechanism / Preclinical Inhalation

2018 · Wang — Hydrogen gas inhibits lung cancer progression through targeting SMC3

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
2018 Mechanism / Preclinical Unspecified

2018 · Zhang — Hydrogen ameliorates oxidative stress via PI3K-Akt signalling pathway in UVB-induced HaCaT cells

International journal of molecular medicine
2017 Mechanism / Preclinical Drinking (HRW)

2017 · Han — Hydrogen Treatment Protects against Cell Death and Senescence Induced by Oxidative Damage

Journal of microbiology and biotechnology
2016 Mechanism / Preclinical InhalationDrinking (HRW)

2016 · Hara — Molecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells

Circulation journal : official journal of the Japanese Circulation Society
2015 Mechanism / Preclinical Unspecified

2015 · Ostojic — Eumelanin-driven production of molecular hydrogen: A novel element of skin defense?

Medical hypotheses
2015 Mechanism / Preclinical InhalationDrinking (HRW)

2015 · Shi et al. — Hydrogen Therapy Reduces Oxidative Stress-associated Risks Following Acute and Chronic Exposure to High-altitude Environment.

Biomedical and environmental sciences : BES
2013 Mechanism / Preclinical Inhalation

2013 · Johnsen — A non-aqueous reduction process for purifying ¹⁵³Gd produced in natural europium targets

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
2012 Mechanism / Preclinical Unspecified

2012 · Madsen et al. — Charge-site-dependent dissociation of hydrogen-rich radical peptide cations upon vacuum UV photoexcitation.

Chemistry (Weinheim an der Bergstrasse, Germany)
2012 Mechanism / Preclinical Bath / Topical

2012 · Kato et al. — Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes.

Journal of photochemistry and photobiology. B, Biology
2011 Mechanism / Preclinical Inhalation

2011 · Terasaki — Hydrogen Therapy Attenuates Irradiation-Induced Lung Damage by Reducing Oxidative Stress

American journal of physiology. Lung cellular and molecular physiology
2011 Mechanism / Preclinical Unspecified

2011 · Yu — Hydrogen-Rich Medium Protects Human Skin Fibroblasts from High Glucose or Mannitol Induced Oxidative Damage

Biochemical and biophysical research communications
2011 Mechanism / Preclinical Unspecified

2011 · Lazzeroni — Production of Clinically Useful Positron Emitter Beams During Carbon Ion Deceleration

Physics in medicine and biology