Neurology

Studies on the brain and nervous system (for example after oxygen deprivation or on cognitive questions), where H₂ is examined as a possible protective factor.

Human studies on molecular hydrogen for Neurology. This page collects the 140 studies catalogued in this area — 12 randomized trials, 24 pilot/observational studies and 57 reviews. Listed newest first.

2026 Review / Meta-analysis Inhalation

2026 · Seneff — The essential role of hydrogen gas recycling by gut microbes in reducing deuterium load in host mitochondria: is trimethylamine oxide a deuterium sensor?

Metabolomics : Official journal of the Metabolomic Society

2026 Review / Meta-analysis Unspecified

2026 · Dumbuya — The protective effects of molecular hydrogen in sepsis-associated encephalopathy: current status.

European journal of pharmacology

2026 Review / Meta-analysis Unspecified

2026 · Paparella — Medical Gases as Emerging Regulators of Paediatric Endocrine and Neurodevelopmental Pathways: A Mini-Review

Acta paediatrica (Oslo, Norway : 1992)

2026 Review / Meta-analysis Inhalation

2026 · Nguyen Puente — Emerging Clinical Applications for Molecular Hydrogen

Respiratory care

2026 Review / Meta-analysis Inhalation

2026 · Merigo — Gas Therapies for Neuro-Protection

Critical care clinics

2026 Review / Meta-analysis Inhalation

2026 · Pan — Stimuli-Responsive Hydrogen Production from Nanomaterials: Design, Regulation and Biomedical Applications

Advanced healthcare materials

2025 Review / Meta-analysis Drinking (HRW)

2025 · Ye — Molecular hydrogen as a novel regulator of cellular pyroptosis: mechanistic insights and therapeutic implications

Molecular biology reports

2025 Review / Meta-analysis Unspecified

2025 · Brandi — Molecular hydrogen therapy: A „democratic” emerging strategy against aging and age-related diseases

Ageing research reviews

2025 Review / Meta-analysis Drinking (HRW)

2025 · Alaqel — Aging, vascular dysfunction, and the blood-brain barrier: unveiling the pathophysiology of stroke in older adults

Biogerontology

2025 Review / Meta-analysis Inhalation

2025 · Zamanian — The Roles of Neuroinflammation in l-DOPA-Induced Dyskinesia: Dissecting the Roles of NF-κB and TNF-α for Novel Pharmacological Therapeutic Approaches

The European journal of neuroscience

2025 Review / Meta-analysis Inhalation

2025 · Li — Application Trends of Hydrogen-generating Nanomaterials for the Treatment of ROS-related Diseases

Biomaterials science

2025 Review / Meta-analysis Unspecified

2025 · Todorović — Hydrogen as an Innovative Nootropic in Health and Disease

Nutrition and health

2024 Review / Meta-analysis Drinking (HRW)

2024 · Dhillon — Hydrogen Water: Extra Healthy or a Hoax?—A Systematic Review

International Journal of Molecular Sciences

2024 Review / Meta-analysis Unspecified

2024 · Slezák — New Possibilities of the Prevention and Treatment of Cardiovascular Pathologies: The Potential of Molecular Hydrogen in the Reduction of Oxidative Stress

Physiological research

2024 Review / Meta-analysis Unspecified

2024 · Kura — The Protective Role of Molecular Hydrogen in Ischemia/Reperfusion Injury

International journal of molecular sciences

2024 Review / Meta-analysis Inhalation

2024 · Tsuzuki — Idiopathic Sudden Sensorineural Hearing Loss: A Review Focused on the Contribution of Vascular Pathologies

Auris, nasus, larynx

2023 Review / Meta-analysis Inhalation Saline / IV Drinking (HRW)

2023 · Kuo — Molecular Hydrogen: Emerging Treatment for Stroke Management

Chemical Research in Toxicology

2023 Review / Meta-analysis Unspecified

2023 · He et al. — The Role of Hydrogen Therapy in Alzheimer's Disease Management: Insights into Mechanisms, Administration Routes, and Future Challenges

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Review / Meta-analysis Unspecified

2023 · Wu et al. — Molecular Hydrogen: An Emerging Therapeutic Medical Gas for Brain Disorders

Molecular neurobiology

2022 Review / Meta-analysis Inhalation

2022 · Biswas — Electrocoagulation and electrooxidation technologies for pesticide removal from water or wastewater: A review

Chemosphere

2022 Review / Meta-analysis Unspecified

2022 · Fu — Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases

Oxidative medicine and cellular longevity

2022 Review / Meta-analysis Unspecified

2022 · Ahmad et al. — Narrative on Hydrogen Therapy and its Clinical Applications: Safety and Efficacy

Current pharmaceutical design

2021 Review / Meta-analysis Inhalation Drinking (HRW)

2021 · Noda — Neuroprotective and Preventative Effects of Molecular Hydrogen

Current Pharmaceutical Design

2021 Review / Meta-analysis Unspecified

2021 · Oren — Amyloid β structural polymorphism, associated toxicity and therapeutic strategies.

Cellular and molecular life sciences : CMLS

2021 Review / Meta-analysis Unspecified

2021 · Schönfeld — How the brain fights fatty acids' toxicity.

Neurochemistry international

2021 Review / Meta-analysis Inhalation

2021 · Magliocca et al. — Inhaled gases as novel neuroprotective therapies in the postcardiac arrest period.

Current opinion in critical care

2021 Review / Meta-analysis Unspecified

2021 · Domoki — Hydrogen-induced Neuroprotection in Neonatal Hypoxic-ischemic Encephalopathy.

Current pharmaceutical design

2021 Review / Meta-analysis Unspecified

2021 · Chen et al. — Neuroprotective Effects of Molecular Hydrogen: A Critical Review.

Neuroscience bulletin

2021 Review / Meta-analysis Unspecified

2021 · Ohta — Direct Targets and Subsequent Pathways for Molecular Hydrogen to Exert Multiple Functions: Focusing on Interventions in Radical Reactions

Current pharmaceutical design

2021 Review / Meta-analysis Inhalation

2021 · Htun et al. — Hydrogen and Therapeutic Gases for Neonatal Hypoxic-Ischemic Encephalopathy: Potential Neuroprotective Adjuncts in Translational Research

Pediatric research

2021 Review / Meta-analysis Inhalation

2021 · Ostojic — Hydrogen as a Potential Therapeutic in Obesity: Targeting the Brain

Trends in endocrinology and metabolism: TEM

2021 Review / Meta-analysis Unspecified

2021 · Lucas — Molecular hydrogen (H₂) as a potential treatment for acute and chronic fatigue

Archiv der Pharmazie

2021 Review / Meta-analysis Unspecified

2021 · Huang et al. — Molecular Hydrogen Application in Stroke: Bench to Bedside

Current pharmaceutical design

2020 Review / Meta-analysis Unspecified

2020 · Wang — Prospects of molecular hydrogen in perioperative neuroprotection from basic research to clinical application

Current Opinion in Anaesthesiology

2020 Review / Meta-analysis Inhalation Bath / Topical Drinking (HRW)

2020 · Kawamura et al. — Application of Molecular Hydrogen as a Novel Antioxidant in Sports Science

Oxidative medicine and cellular longevity

2019 Review / Meta-analysis Unspecified

2019 · Morris — Myalgic encephalomyelitis/chronic fatigue syndrome: From pathophysiological insights to novel therapeutic opportunities.

Pharmacological research

2019 Review / Meta-analysis Inhalation Saline / IV Drinking (HRW)

2019 · LeBaron et al. — A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress.

Molecules (Basel, Switzerland)

2019 Review / Meta-analysis Drinking (HRW)

2019 · Noda et al. — Circulating messenger for neuroprotection induced by molecular hydrogen.

Canadian journal of physiology and pharmacology

2019 Review / Meta-analysis Drinking (HRW)

2019 · Ishibashi — Therapeutic Efficacy of Molecular Hydrogen: A New Mechanistic Insight.

Current pharmaceutical design

2019 Review / Meta-analysis Unspecified

2019 · Cejka et al. — The preventive and therapeutic effects of molecular hydrogen in ocular diseases and injuries where oxidative stress is involved.

Free radical research

2019 Review / Meta-analysis Inhalation

2019 · Li et al. — Hydrogen as a complementary therapy against ischemic stroke: A review of the evidence.

Journal of the neurological sciences

2019 Review / Meta-analysis Saline / IV

2019 · Wang et al. — Neonatal hypoxic-ischemic encephalopathy: emerging therapeutic strategies based on pathophysiologic phases of the injury.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2018 Review / Meta-analysis Unspecified

2018 · Morris — The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders

Sleep medicine reviews

2017 Review / Meta-analysis Inhalation Saline / IV Drinking (HRW)

2017 · Iketani — Molecular Hydrogen as a Neuroprotective Agent

Current Neuropharmacology

2016 Review / Meta-analysis Unspecified

2016 · Zheng — Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis

Oxidative medicine and cellular longevity

2015 Review / Meta-analysis Unspecified

2015 · Ostojic — Molecular hydrogen in sports medicine: new therapeutic perspectives.

International journal of sports medicine

2014 Review / Meta-analysis Saline / IV

2014 · Fernández-Gajardo et al. — Novel therapeutic strategies for traumatic brain injury: acute antioxidant reinforcement.

CNS drugs

2013 Review / Meta-analysis Unspecified

2013 · Schönfeld — Why does brain metabolism not favor burning of fatty acids to provide energy? Reflections on disadvantages of the use of free fatty acids as fuel for brain

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

2013 Review / Meta-analysis Inhalation

2013 · Lucas — Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway

Molecular neurobiology

2012 Review / Meta-analysis Drinking (HRW)

2012 · Ohno et al. — Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases.

Oxidative medicine and cellular longevity

2011 Review / Meta-analysis Unspecified

2011 · Noda et al. — The principle and the potential approach to ROS-dependent cytotoxicity by non-pharmaceutical therapies: optimal use of medical gases with antioxidant properties.

Current pharmaceutical design

2011 Review / Meta-analysis Unspecified

2011 · Naeem et al. — Defective protein folding and aggregation as the basis of neurodegenerative diseases: the darker aspect of proteins.

Cell biochemistry and biophysics

2011 Review / Meta-analysis Drinking (HRW)

2011 · Acuña Castroviejo — Melatonin-Mitochondria Interplay in Health and Disease

Current topics in medicinal chemistry

2010 Review / Meta-analysis Unspecified

2010 · Hong — Research Advances on Hydrogen Therapy in Nervous System Diseases

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences

2010 Review / Meta-analysis Inhalation

2010 · Shen — Hydrogen as a novel and effective treatment of acute carbon monoxide poisoning.

Medical hypotheses

2002 Review / Meta-analysis Drinking (HRW)

2002 · Acuña Castroviejo et al. — Melatonin, mitochondrial homeostasis and mitochondrial-related diseases

Current topics in medicinal chemistry

1996 Review / Meta-analysis Unspecified

1996 · Mehta — Magnetization Transfer Magnetic Resonance Imaging: A Clinical Review

Topics in magnetic resonance imaging : TMRI

2025 RCT Human H₂ therapy Drinking (HRW)

2025 · Todorovic — The Effects of 8-Week Hydrogen-Rich Water Consumption on Appetite, Body Composition, Sleep Quality, and Circulating Glucagon-like Peptide-1 in Obese Men and Women (HYDRAPPET): A Randomized Controlled Trial

Medicina (Kaunas)

2023 RCT Human H₂ therapy Inhalation

2023 · Lin — Hydrogen Gas Treatment Improves Postoperative Delirium and Cognitive Dysfunction in Elderly Noncardiac Patients

Journal of Personalized Medicine

2021 RCT Human H₂ therapy Inhalation

2021 · Yoritaka — Randomized double-blind placebo-controlled trial of hydrogen inhalation for Parkinson's disease: a pilot study

Neurological Sciences

2021 RCT Human H₂ therapy Saline / IV

2021 · Takeuchi — Intravenous Hydrogen Therapy With Intracisternal Magnesium Sulfate Infusion in Severe Aneurysmal Subarachnoid Hemorrhage

Stroke

2021 RCT Human H₂ therapy Drinking (HRW)

2021 · Zanini — The effects of 6-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in older adults aged 70 years and over: A randomized controlled pilot trial

Experimental Gerontology

2018 RCT Human H₂ therapy Drinking (HRW)

2018 · Yoritaka — Randomized, Double-Blind, Multicenter Trial of Hydrogen Water for Parkinson's Disease

Movement disorders : official journal of the Movement Disorder Society

2018 RCT Human H₂ therapy Drinking (HRW)

2018 · Nishimaki — Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment

Current Alzheimer research

2017 RCT Human H₂ therapy Inhalation

2017 · Tamura — Efficacy of Inhaled Hydrogen on Neurological Outcome Following Brain Ischemia During Post-Cardiac Arrest Care (HYBRID II Trial): Study Protocol for a Randomized Controlled Trial

Trials

2017 RCT Human H₂ therapy Inhalation Saline / IV

2017 · Ono et al. — Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

2016 RCT Human H₂ therapy Drinking (HRW)

2016 · Yoritaka et al. — A randomized double-blind multi-center trial of hydrogen water for Parkinson's disease: protocol and baseline characteristics.

BMC neurology

2014 RCT Human H₂ therapy Saline / IV

2014 · Takeuchi et al. — Effects of intravenous hydrogen-rich fluid combined with intra-cisternal magnesium sulfate in severe aneurysmal subarachnoid hemorrhage: study protocol for a randomized controlled trial.

BMC neurology

2013 RCT Human H₂ therapy Drinking (HRW)

2013 · Yoritaka et al. — Pilot study of H₂ therapy in Parkinson's disease: a randomized double-blind placebo-controlled trial.

Movement disorders : official journal of the Movement Disorder Society

2026 Pilot / Observational Human H₂ therapy Drinking (HRW)

2026 · Li — Adjunctive Molecular Hydrogen Capsule Therapy in Empyema Complicated by Chronic Inflammatory Demyelinating Polyneuropathy: A Case Report

In vivo (Athens, Greece)

2026 Pilot / Observational Human H₂ therapy Inhalation Bath / Topical

2025 · Moriya et al. — Hydrogen Inhalation Is Associated With a Transient Rightward Shift in Prefrontal Oxyhemoglobin Asymmetry and Autonomic Modulation

Scientific reports

2026 Pilot / Observational Human H₂ therapy Unspecified

2026 · Liu et al. — Adjuvant Molecular Hydrogen Therapy in SLE-associated Pulmonary Arterial Hypertension: A Case Report on Immunomodulatory Effects on Regulatory and Effector Lymphocytes

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Inhalation

2025 · Habet et al. — Hydrogen-FAST: Study Protocol for Inhaled Hydrogen Gas as Adjunctive Therapy in Refractory Cardiac Arrest (ECPR)

Trials

2025 Pilot / Observational Human H₂ therapy Drinking (HRW)

2025 · Ren et al. — A Case Report of Adjuvant Molecular Hydrogen Therapy in Refractory Rheumatoid Arthritis With Atlantoaxial Subluxation

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Drinking (HRW)

2025 · Hruby et al. — Hydrogen-Rich Water Consumption for Acute and Residual Fatigue After Simulated Football Matches: Protocol for a Randomized, Double-Blinded, Placebo-Controlled, Parallel Trial

JMIR research protocols

2025 Pilot / Observational Human H₂ therapy Drinking (HRW)

2025 · Tu et al. — Molecular Hydrogen Therapy in Rheumatoid Arthritis: A Case Report on the Amelioration of Methotrexate-induced Myelosuppression and Immune Modulation

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Hsu et al. — Molecular Hydrogen Therapy Enhances Immune Markers in Treg, Plasma, Tr1 Cells, and KLRG1 Expression on Tc Cells: A Case of Acute SDH With Midline Shift and Uncal Herniation Post-decompressive Craniectomy

In vivo (Athens, Greece)

2024 Pilot / Observational Human H₂ therapy Inhalation

2024 · Tamura — Combination of Hydrogen Inhalation and Hypothermic Temperature Control After Out-of-Hospital Cardiac Arrest: A Post hoc Analysis of the Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During PostCardiac Arrest Care II Trial

Critical Care Medicine

2024 Pilot / Observational Human H₂ therapy Drinking (HRW)

2024 · Chen — Molecular Hydrogen Therapy in Aneurysmal SAH With RA and Newly-diagnosed SLE, Complicated With Acute Ischemic Infarction: A Case Report of Improved Immune Markers Including Tr1 Cells, Breg Cells and TIM3 Expression on Tc Cells.

In vivo (Athens, Greece)

2024 Pilot / Observational Human H₂ therapy Unspecified

2024 · Xie — A novel intervention of molecular hydrogen on the unbalance of the gut microbiome in opioid addiction: Experimental and human studies.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024 Pilot / Observational Human H₂ therapy Inhalation

2024 · Ichikawa — Realizing brain therapy with „smart medicine“: mechanism and case report of molecular hydrogen inhalation for Parkinson's disease.

Medical gas research

2024 Pilot / Observational Human H₂ therapy Inhalation Drinking (HRW)

2024 · Lin — Early Hydrogen-Oxygen Gas Mixture Inhalation in Patients with Aneurysmal Subarachnoid Hemorrhage (HOMA): study protocol for a randomized controlled trial.

Trials

2024 Pilot / Observational Human H₂ therapy Inhalation

2024 · Liu — The Benefit of Hydrogen Gas as an Adjunctive Therapy for Chronic Obstructive Pulmonary Disease.

Medicina (Kaunas, Lithuania)

2023 Pilot / Observational Human H₂ therapy Inhalation Drinking (HRW)

2023 · Wang — Effects of molecular hydrogen intervention on the gut microbiome in methamphetamine abusers with mental disorder.

Brain research bulletin

2022 Pilot / Observational Human H₂ therapy Saline / IV

2022 · Benjamin — A potential clinical application of hydrogen-rich saline in patients with traumatic brain injury.

Journal of pediatric surgery

2021 Pilot / Observational Human H₂ therapy Drinking (HRW)

2021 · Hong — Effects of concomitant use of hydrogen water and photobiomodulation on Parkinson disease: A pilot study

Medicine

2019 Pilot / Observational Human H₂ therapy Tablets Drinking (HRW)

2019 · Javorac et al. — Case Report: Buccal administration of hydrogen-producing blend after a mild traumatic brain injury in a professional athlete.

F1000Research

2018 Pilot / Observational

2018 · Suzuki — Quantification of Hydrogen Production by Intestinal Bacteria That Are Specifically Dysregulated in Parkinson's Disease

PloS one

2017 Pilot / Observational Human H₂ therapy Inhalation

2017 · Katsumata et al. — The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction — First Pilot Study in Humans.

Circulation journal : official journal of the Japanese Circulation Society

2016 Pilot / Observational Human H₂ therapy Inhalation

2016 · Tamura et al. — Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome — First-in-Human Pilot Study.

Circulation journal : official journal of the Japanese Circulation Society

2006 Pilot / Observational

2006 · Asaturian et al. — Temporary Clipping and Cerebral Blood Flow in Patients with Cerebral Aneurysms

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko

1993 Pilot / Observational

1993 · Suzuki — Effect of endogenous opioids on gastric functions in man

[Hokkaido igaku zasshi] The Hokkaido journal of medical science

1988 Pilot / Observational

1988 · Toma et al. — Effect of Endocrine Treatment on Prostatic Blood Flow in Patients with Prostatic Adenocarcinoma

The Journal of urology

2026 Mechanism / Preclinical Inhalation

2026 · Wang — Hydrogen gas inhalation alleviated cerebral ischemia/reperfusion injury by regulating mitophagy in SH-SY5Y cells and mice via PTEN-induced kinase 1/Parkin pathway.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

2026 Mechanism / Preclinical Inhalation

2026 · Zhao — Molecular hydrogen triggers TRPC4-TRPC4AP-dependent reversible calcium transients via extracellular influx

Theranostics

2025 Mechanism / Preclinical Unspecified

2025 · Chu — Hydrogen Enhanced Photothermal Therapy for Redox-regulated Tumor Apoptosis and Immune Reprogramming

Acta biomaterialia

2025 Mechanism / Preclinical Unspecified

2025 · Li — Hydrogen promoted mitochondrial autophagy and alleviated CIH-induced vascular endothelial cell senescence by regulating oxidative stress.

European journal of pharmacology

2025 Mechanism / Preclinical Inhalation

2025 · Zhang — RNA-Seq Reveals the Mechanism of Synergistic Hydrogen-Chemotherapy Based on Active Magnesium Micromotors for Inhibiting Glioblastoma Recurrence by Modulating Tumor Microenvironment.

Small (Weinheim an der Bergstrasse, Germany)

2024 Mechanism / Preclinical Unspecified

2024 · Benoit — d-aspartate, an amino-acid important for human health, supports anaerobic respiration in several Campylobacter species.

Research in microbiology

2024 Mechanism / Preclinical Saline / IV Drinking (HRW)

2024 · Chen — Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway.

World journal of gastroenterology

2024 Mechanism / Preclinical Inhalation

2024 · McCurry — Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas.

Cell

2024 Mechanism / Preclinical Drinking (HRW)

2024 · Lu et al. — Decoupling the Mutual Promotion of Inflammation and Oxidative Stress Mitigates Cognitive Decline and Depression-Like Behavior in rmTBI Mice by Promoting Myelin Renewal and Neuronal Survival

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024 Mechanism / Preclinical Inhalation

2024 · Cui — High-concentration hydrogen inhalation mitigates sepsis-associated encephalopathy in mice by improving mitochondrial dynamics

CNS Neuroscience & Therapeutics

2023 Mechanism / Preclinical Saline / IV

2023 · Dumbuya — Hydrogen-rich saline regulates NLRP3 inflammasome activation in sepsis-associated encephalopathy rat model

International immunopharmacology

2023 Mechanism / Preclinical Inhalation

2023 · Iketani — H₂-induced transient upregulation of phospholipids with suppression of energy metabolism

Medical gas research

2023 Mechanism / Preclinical Bath / Topical

2023 · Sahoo — Hydrogen-producing Photocatalyst at Sunscreen for Athletes in Preventing and Healing Muscle-nerve-skin Injuries

Current topics in medicinal chemistry

2022 Mechanism / Preclinical Inhalation Drinking (HRW)

2022 · An — Gender-based differences in neuroprotective effects of hydrogen gas against intracerebral hemorrhage-induced depression

Neurochemistry international

2022 Mechanism / Preclinical Inhalation

2022 · Liu — In vivo microelectrode monitoring of real-time hydrogen concentration in different tissues of rats after inhaling hydrogen gas

Medical gas research

2021 Mechanism / Preclinical Inhalation Drinking (HRW)

2021 · Yin et al. — Hydrogen Gas with Extracorporeal Cardiopulmonary Resuscitation Improves Survival after Prolonged Cardiac Arrest in Rats

Journal of translational medicine

2021 Mechanism / Preclinical Drinking (HRW)

2021 · LeBaron et al. — An H₂-Infused, Nitric Oxide-Producing Functional Beverage as a Neuroprotective Agent for TBIs and Concussions

Journal of integrative neuroscience

2021 Mechanism / Preclinical Drinking (HRW)

2021 · Li et al. — Hydrogen-rich water attenuates the radiotoxicity induced by tritium exposure in vitro and in vivo

Journal of radiation research

2021 Mechanism / Preclinical Inhalation Drinking (HRW)

2021 · Ostojic — Does drinking water rich in hydrogen gas revive brain hypometabolism in neurodegeneration by SCFAs upregulation?

European journal of clinical nutrition

2020 Mechanism / Preclinical Unspecified

2020 · Wang — Hydrogen exerts neuroprotection by activation of the miR-21/PI3K/AKT/GSK-3β pathway in an in vitro model of traumatic brain injury.

Journal of cellular and molecular medicine

2020 Mechanism / Preclinical Inhalation

2020 · Zhuang — Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway.

International immunopharmacology

2020 Mechanism / Preclinical Unspecified

2020 · Ishihara — Molecular hydrogen suppresses superoxide generation in the mitochondrial complex I and reduced mitochondrial membrane potential.

Biochemical and biophysical research communications

2020 Mechanism / Preclinical Saline / IV Drinking (HRW)

2020 · Jiao — Protective effects of hydrogen-rich saline against experimental diabetic peripheral neuropathy via activation of the mitochondrial ATP-sensitive potassium channel in rats.

Molecular medicine reports

2019 Mechanism / Preclinical Inhalation

2019 · Chen et al. — Inhaling Hydrogen Ameliorates Early Postresuscitation EEG Characteristics in an Asphyxial Cardiac Arrest Rat Model.

BioMed research international

2019 Mechanism / Preclinical Drinking (HRW)

2019 · Bordoni — Positive Effect of an Electrolyzed Reduced Water on Gut Permeability, Fecal Microbiota and Liver in an Animal Model of Parkinson's Disease

PloS one

2019 Mechanism / Preclinical Inhalation

2019 · Liu — Molecular Hydrogen Suppresses Glioblastoma Growth via Inducing the Glioma Stem-Like Cell Differentiation

Stem cell research & therapy

2019 Mechanism / Preclinical Unspecified

2019 · Htun — Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model.

Scientific reports

2019 Mechanism / Preclinical Inhalation

2019 · Liu — In vitro and in vivo studies of Mg-30Sc alloys with different phase structure for potential usage within bone.

Acta biomaterialia

2018 Mechanism / Preclinical Drinking (HRW)

2018 · Yuan — Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway

The Journal of surgical research

2018 Mechanism / Preclinical Drinking (HRW)

2018 · Ostojic — Inadequate Production of H₂ by Gut Microbiota and Parkinson Disease

Trends in endocrinology and metabolism: TEM

2017 Mechanism / Preclinical Inhalation Drinking (HRW)

2017 · Murakami — Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis

PloS one

2017 Mechanism / Preclinical Unspecified

2017 · Biswas — A Comprehensive Computational Study on Pathogenic Missense Mutations Spanning the RING2 and REP Domains of Parkin Protein

Gene

2016 Mechanism / Preclinical Unspecified

2016 · Davoren — Design and Optimization of Selective Azaindole Amide M1 Positive Allosteric Modulators

Bioorganic & medicinal chemistry letters

2016 Mechanism / Preclinical Saline / IV

2016 · Zhang — Treatment with Hydrogen-Rich Saline Delays Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis

Neurochemical research

2015 Mechanism / Preclinical Drinking (HRW)

2015 · Lin et al. — Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells.

Chemico-biological interactions

2015 Mechanism / Preclinical Unspecified

2015 · Chikan et al. — Atomic Insight into the Altered O6-Methylguanine-DNA Methyltransferase Protein Architecture in Gastric Cancer.

PloS one

2014 Mechanism / Preclinical Drinking (HRW)

2014 · Brenner — Parkinson's disease may be due to failure of melanin in the Substantia Nigra to produce molecular hydrogen from dissociation of water.

Medical hypotheses

2014 Mechanism / Preclinical Drinking (HRW)

2014 · Mano et al. — Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion.

Free radical biology & medicine

2012 Mechanism / Preclinical Inhalation

2012 · Wong et al. — A hydrogen gas-water equilibration method produces accurate and precise stable hydrogen isotope ratio measurements in nutrition studies.

The Journal of nutrition

2010 Mechanism / Preclinical Saline / IV

2010 · Qian — The hypothesis of an effective safe and novel radioprotective agent: hydrogen-rich solution.

The West Indian medical journal

2010 Mechanism / Preclinical Unspecified

2010 · Kurisaki — Spontaneous adjustment mechanism in an RNA-binding protein: cooperation between energetic stabilization and target search enhancement.

Protein and peptide letters

2010 Mechanism / Preclinical Inhalation Saline / IV Drinking (HRW)

1999 · Tamori — Role of calcitonin gene-related peptide and capsaicin-sensitive afferents in central thyrotropin-releasing hormone-induced hepatic hyperemia.

European journal of pharmacology

1989 Mechanism / Preclinical Inhalation

1989 · Heizmann — GasPak Plus versus Anaerocult A — two carbon dioxide/hydrogen systems for cultivation of anaerobes.

Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology