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Sports & Exercise

Research on exertion, recovery and performance — H₂ is tested for possible effects on fatigue, muscle soreness and post-exercise inflammation.

Human studies on molecular hydrogen for Sports & Exercise. This page collects the 162 studies catalogued in this area — 30 randomized trials, 30 pilot/observational studies and 37 reviews. Listed newest first.

2025 Review / Meta-analysis Unspecified

2025 · Zajac — Molecular Hydrogen in the Treatment of Respiratory Diseases

International journal of molecular sciences
2025 Review / Meta-analysis Drinking (HRW)

2025 · Alaqel — Aging, vascular dysfunction, and the blood-brain barrier: unveiling the pathophysiology of stroke in older adults

Biogerontology
2024 Review / Meta-analysis Drinking (HRW)

2024 · Dhillon — Hydrogen Water: Extra Healthy or a Hoax?—A Systematic Review

International Journal of Molecular Sciences
2024 Review / Meta-analysis Unspecified

2024 · Slezák — New Possibilities of the Prevention and Treatment of Cardiovascular Pathologies: The Potential of Molecular Hydrogen in the Reduction of Oxidative Stress

Physiological research
2021 Review / Meta-analysis Unspecified

2021 · Oren — Amyloid β structural polymorphism, associated toxicity and therapeutic strategies.

Cellular and molecular life sciences : CMLS
2021 Review / Meta-analysis InhalationDrinking (HRW)

2021 · Bragina — Intestinal microbiota of athletes.

Voprosy pitaniia
2021 Review / Meta-analysis Unspecified

2021 · Shi et al. — Hydrogen treatment: a novel option in liver diseases.

Clinical medicine (London, England)
2021 Review / Meta-analysis InhalationSaline / IV

2021 · Sano et al. — Hydrogen Gas Therapy: From Preclinical Studies to Clinical Trials.

Current pharmaceutical design
2021 Review / Meta-analysis Unspecified

2021 · Nogueira et al. — Recent Advances in Molecular Hydrogen Research Reducing Exercise-Induced Oxidative Stress and Inflammation.

Current pharmaceutical design
2021 Review / Meta-analysis Unspecified

2021 · Bajgai et al. — Role of Molecular Hydrogen in Skin Diseases and its Impact in Beauty.

Current pharmaceutical design
2021 Review / Meta-analysis Unspecified

2021 · Lucas — Molecular hydrogen (H₂) as a potential treatment for acute and chronic fatigue

Archiv der Pharmazie
2021 Review / Meta-analysis InhalationSaline / IVDrinking (HRW)

2021 · Ostojic — Hydrogen Gas as an Exotic Performance-Enhancing Agent: Challenges and Opportunities

Current pharmaceutical design
2021 Review / Meta-analysis Unspecified

2021 · Slezak et al. — Oxidative Stress and Pathways of Molecular Hydrogen Effects in Medicine

Current pharmaceutical design
2020 Review / Meta-analysis Inhalation

2020 · Hirano et al. — A „philosophical molecule,” hydrogen may overcome senescence and intractable diseases

Medical gas research
2020 Review / Meta-analysis InhalationBath / TopicalDrinking (HRW)

2020 · Kawamura et al. — Application of Molecular Hydrogen as a Novel Antioxidant in Sports Science

Oxidative medicine and cellular longevity
2020 Review / Meta-analysis Drinking (HRW)

2020 · Benoit — Molecular Hydrogen Metabolism: a Widespread Trait of Pathogenic Bacteria and Protists

Microbiology and molecular biology reviews : MMBR
2019 Review / Meta-analysis Unspecified

2019 · Morris — Myalgic encephalomyelitis/chronic fatigue syndrome: From pathophysiological insights to novel therapeutic opportunities.

Pharmacological research
2019 Review / Meta-analysis Drinking (HRW)

2019 · Noda et al. — Circulating messenger for neuroprotection induced by molecular hydrogen.

Canadian journal of physiology and pharmacology
2019 Review / Meta-analysis InhalationDrinking (HRW)

2019 · LeBaron et al. — Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes.

Canadian journal of physiology and pharmacology
2019 Review / Meta-analysis Saline / IV

2019 · Wang et al. — Neonatal hypoxic-ischemic encephalopathy: emerging therapeutic strategies based on pathophysiologic phases of the injury.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2018 Review / Meta-analysis Unspecified

2018 · Ye — Recent Advances in the Electro-Oxidation of Urea for Direct Urea Fuel Cell and Urea Electrolysis.

Topics in current chemistry (Cham)
2018 Review / Meta-analysis Unspecified

2018 · Zhang — Hydrogen Therapy in Cardiovascular and Metabolic Diseases: from Bench to Bedside

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
2018 Review / Meta-analysis Unspecified

2018 · Morris — The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders

Sleep medicine reviews
2018 Review / Meta-analysis Inhalation

2018 · Hylemon — Metabolism of hydrogen gases and bile acids in the gut microbiome

FEBS letters
2016 Review / Meta-analysis Unspecified

2016 · Zheng — Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis

Oxidative medicine and cellular longevity
2016 Review / Meta-analysis Unspecified

2016 · Verghese — Complementary therapies for bladder pain syndrome: a systematic review

International urogynecology journal
2015 Review / Meta-analysis Unspecified

2015 · Dubé — Direct Interspecies Electron Transfer in Anaerobic Digestion: A Review

Advances in biochemical engineering/biotechnology
2015 Review / Meta-analysis Unspecified

2015 · Ostojic — Targeting molecular hydrogen to mitochondria: barriers and gateways.

Pharmacological research
2015 Review / Meta-analysis Unspecified

2015 · Ostojic — Molecular hydrogen in sports medicine: new therapeutic perspectives.

International journal of sports medicine
2015 Review / Meta-analysis InhalationDrinking (HRW)

2015 · Osonoi — [Alpha-glucosidase inhibitor]. (Nihon Rinsho)

Nihon rinsho. Japanese journal of clinical medicine
2013 Review / Meta-analysis Inhalation

2013 · Lucas — Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway

Molecular neurobiology
2011 Review / Meta-analysis Drinking (HRW)

2011 · Acuña Castroviejo — Melatonin-Mitochondria Interplay in Health and Disease

Current topics in medicinal chemistry
2010 Review / Meta-analysis Unspecified

2010 · Otzen — Amyloid formation in surfactants and alcohols: membrane mimetics or structural switchers?

Current protein & peptide science
2009 Review / Meta-analysis InhalationDrinking (HRW)

2009 · Mahlen — Oral abscess caused by Campylobacter rectus: case report and literature review.

Journal of clinical microbiology
2004 Review / Meta-analysis InhalationDrinking (HRW)

2004 · Züttel — Hydrogen storage methods

Die Naturwissenschaften
2002 Review / Meta-analysis Drinking (HRW)

2002 · Acuña Castroviejo et al. — Melatonin, mitochondrial homeostasis and mitochondrial-related diseases

Current topics in medicinal chemistry
1996 Review / Meta-analysis Unspecified

1996 · Mehta — Magnetization Transfer Magnetic Resonance Imaging: A Clinical Review

Topics in magnetic resonance imaging : TMRI
2026 RCT Human H₂ therapy Drinking (HRW)

2026 · Stolecka-Warzecha — Redox Water Consumption Attenuates Exercise-Induced Inflammation and Oxidative Stress in Physically Active Adults: A Randomized Controlled Trial

Nutrients
2025 RCT Human H₂ therapy TabletsDrinking (HRW)

2025 · Ogannisyan — Hydrogen-Rich Water Decreases Muscle Damage and Improves Power Endurance in Elite Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial

Journal of Lifestyle Medicine
2025 RCT Human H₂ therapy Drinking (HRW)

2025 · Kuzmanovic — The effects of drinking hydrogen-rich water for six weeks on exercise-related biomarkers in exercise-naïve men and women over 50 years following resistance training program: a randomized controlled pilot trial

Research in Sports Medicine
2025 RCT Human H₂ therapy Drinking (HRW)

2025 · Khlifi — Pre-Exercise Ingestion of Hydrogen-Rich Cold Water Enhances Endurance Performance and Lactate Response in Heat

Medicina (Kaunas)
2025 RCT Human H₂ therapy Unspecified

2025 · Korchazhkina — Effectiveness of Non-Drug Technologies to Increase Stress Resistance in Persons with Extreme Work Profiles and Susceptibility for Professional Burnout

Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury
2025 RCT Human H₂ therapy Unspecified

2025 · Shogenova — Efficiency and Safety of the Combined Use of Thermal Heliox, Nitric Oxide and Molecular Hydrogen in COPD Exacerbation with Respiratory Failure and Pulmonary Hypertension in the Post-COVID Period

Terapevticheskii arkhiv
2024 RCT Human H₂ therapy InhalationDrinking (HRW)

2024 · Zhao — Hydrogen gas inhalation prior to high-intensity training reduces attenuation of nitric oxide bioavailability in male rugby players

PeerJ
2024 RCT Human H₂ therapy Inhalation

2024 · Dong — Inhalation of Hydrogen-Rich Gas before Acute Exercise Alleviates Exercise Fatigue: A Randomized Crossover Study

International journal of sports medicine
2024 RCT Human H₂ therapy Drinking (HRW)

2024 · Tan — The Effect of 14-Day Consumption of Hydrogen-Rich Water Alleviates Fatigue but Does Not Ameliorate Dyspnea in Long-COVID Patients: A Pilot, Single-Blind, and Randomized, Controlled Trial

Nutrients
2022 RCT Human H₂ therapy Drinking (HRW)

2022 · Botek — Hydrogen Rich Water Consumption Positively Affects Muscle Performance, Lactate Response, and Alleviates Delayed Onset of Muscle Soreness After Resistance Training

Journal of Strength and Conditioning Research
2022 RCT Human H₂ therapy Inhalation

2022 · Botek — Molecular Hydrogen Positively Affects Physical and Respiratory Function in Acute Post-COVID-19 Patients: A New Perspective in Rehabilitation

International Journal of Environmental Research and Public Health
2022 RCT Human H₂ therapy Drinking (HRW)

2022 · Botek — Molecular Hydrogen Mitigates Performance Decrement during Repeated Sprints in Professional Soccer Players

Nutrients
2022 RCT Human H₂ therapy Drinking (HRW)

2022 · Valenta — Acute pre-exercise hydrogen rich water intake does not improve running performance at maximal aerobic speed in trained track and field runners: A randomized, double-blind, placebo-controlled crossover study

PLoS ONE
2022 RCT Human H₂ therapy Drinking (HRW)

2022 · Alharbi — The Acute Effects of a Single Dose of Molecular Hydrogen Supplements on Responses to Ergogenic Adjustments during High-Intensity Intermittent Exercise in Humans

Nutrients
2022 RCT

2022 · Eda — Effects of Intestinal Bacterial Hydrogen Gas Production on Muscle Recovery following Intense Exercise in Adult Men: A Pilot Study

Nutrients
2021 RCT Human H₂ therapy Bath / TopicalDrinking (HRW)

2021 · Javorac — Hydrotherapy with hydrogen-rich water compared with RICE protocol following acute ankle sprain in professional athletes: a randomized non-inferiority pilot trial

Research in Sports Medicine
2021 RCT Human H₂ therapy Drinking (HRW)

2021 · Alharbi — Application of Molecular Hydrogen as an Antioxidant in Responses to Ventilatory and Ergogenic Adjustments during Incremental Exercise in Humans

Nutrients
2021 RCT Human H₂ therapy Saline / IV

2021 · Takeuchi — Intravenous Hydrogen Therapy With Intracisternal Magnesium Sulfate Infusion in Severe Aneurysmal Subarachnoid Hemorrhage

Stroke
2020 RCT Human H₂ therapy Drinking (HRW)

2020 · Ooi — Acute ingestion of hydrogen-rich water does not improve incremental treadmill running performance in endurance-trained athletes

Applied Physiology, Nutrition, and Metabolism
2020 RCT Human H₂ therapy InhalationBath / Topical

2020 · Shibayama — Impact of hydrogen-rich gas mixture inhalation through nasal cannula during post-exercise recovery period on subsequent oxidative stress, muscle damage, and exercise performances in men

Medical Gas Research
2020 RCT Human H₂ therapy Drinking (HRW)

2020 · Hori — Two-week continuous supplementation of hydrogen-rich water increases peak oxygen uptake during an incremental cycling exercise test in healthy humans: a randomized, single-blinded, placebo-controlled study

Medical Gas Research
2020 RCT Human H₂ therapy Drinking (HRW)

2020 · Dobashi et al. — Hydrogen-rich water suppresses the reduction in blood total antioxidant capacity induced by 3 consecutive days of severe exercise in physically active males.

Medical gas research
2019 RCT Human H₂ therapy Drinking (HRW)

2019 · Mikami — Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study

Canadian Journal of Physiology and Pharmacology
2019 RCT Human H₂ therapy Drinking (HRW)

2019 · Botek — Hydrogen Rich Water Improved Ventilatory, Perceptual and Lactate Responses to Exercise

International Journal of Sports Medicine
2017 RCT Human H₂ therapy Inhalation

2017 · Tamura — Efficacy of Inhaled Hydrogen on Neurological Outcome Following Brain Ischemia During Post-Cardiac Arrest Care (HYBRID II Trial): Study Protocol for a Randomized Controlled Trial

Trials
2017 RCT Human H₂ therapy InhalationSaline / IV

2017 · Ono et al. — Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
2014 RCT Human H₂ therapy TabletsBath / TopicalDrinking (HRW)

2014 · Ostojic et al. — Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries.

Postgraduate medicine
2014 RCT Human H₂ therapy Drinking (HRW)

2014 · Ostojic et al. — Hydrogen-rich water affected blood alkalinity in physically active men.

Research in sports medicine (Print)
1999 RCT

1999 · Cole — Consequences of incomplete carbohydrate absorption from fruit juice consumption in infants.

Archives of pediatrics & adolescent medicine
1998 RCT

1998 · Poppitt et al. — Energy expenditure and net substrate utilization in men ingesting usual and high amounts of nonstarch polysaccharides

The American journal of clinical nutrition
2026 Pilot / Observational Human H₂ therapy Drinking (HRW)

2026 · Li — Adjunctive Molecular Hydrogen Capsule Therapy in Empyema Complicated by Chronic Inflammatory Demyelinating Polyneuropathy: A Case Report

In vivo (Athens, Greece)
2026 Pilot / Observational Human H₂ therapy InhalationBath / Topical

2025 · Moriya et al. — Hydrogen Inhalation Is Associated With a Transient Rightward Shift in Prefrontal Oxyhemoglobin Asymmetry and Autonomic Modulation

Scientific reports
2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Kotenko et al. — Biochemical Markers of Stress in Medical Workers With Occupational Burnout Syndrome and Their Dynamics Under Physiotherapeutic Factors

Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury
2025 Pilot / Observational Human H₂ therapy Drinking (HRW)

2025 · Ren et al. — A Case Report of Adjuvant Molecular Hydrogen Therapy in Refractory Rheumatoid Arthritis With Atlantoaxial Subluxation

In vivo (Athens, Greece)
2025 Pilot / Observational Human H₂ therapy Drinking (HRW)

2025 · Hruby et al. — Hydrogen-Rich Water Consumption for Acute and Residual Fatigue After Simulated Football Matches: Protocol for a Randomized, Double-Blinded, Placebo-Controlled, Parallel Trial

JMIR research protocols
2025 Pilot / Observational Human H₂ therapy Drinking (HRW)

2025 · Lui et al. — Predicting Therapeutic Response to Molecular Hydrogen in Autoimmune Diseases via Immunophenotyping

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Tsai et al. — Molecular Hydrogen as an Adjuvant Therapy in Comorbid Sjögren's Syndrome, SLE, and ILD: A Case Report on Immune Modulation and Fatigue Reduction

In vivo (Athens, Greece)
2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Lin et al. — Molecular Hydrogen Capsule Therapy for Primary Biliary Cholangitis With Elevated IgG4: A Case Report on Immune Marker Normalization

In vivo (Athens, Greece)
2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Hsu et al. — Molecular Hydrogen Therapy Enhances Immune Markers in Treg, Plasma, Tr1 Cells, and KLRG1 Expression on Tc Cells: A Case of Acute SDH With Midline Shift and Uncal Herniation Post-decompressive Craniectomy

In vivo (Athens, Greece)
2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Lin et al. — Molecular Hydrogen as an Adjuvant Therapy in Severe Lupus Serositis With Heart Failure: A Case Report on Immune Modulation and Fatigue Reduction

In vivo (Athens, Greece)
2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Nakayama et al. — Hemodialysis Employing Molecular Hydrogen (H₂) Enriched Dialysis Solution May Improve Dialysis-Related Fatigue Through Impact on Energy Metabolism

Scientific reports
2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Lin et al. — Molecular Hydrogen as a Potential Adjunctive Therapy to Improve Renal Function and Reduce Fatigue in an Elderly Patient With Chronic Comorbidities: A Case Report

In vivo (Athens, Greece)
2024 Pilot / Observational Human H₂ therapy Inhalation

2024 · Dong — Hydrogen-Rich Gas Enhanced Sprint-Interval Performance: Metabolomic Insights into Underlying Mechanisms

Nutrients
2024 Pilot / Observational Human H₂ therapy Inhalation

2024 · Hirano — Successful treatment of myalgic encephalomyelitis/chronic fatigue syndrome using hydrogen gas: four case reports.

Medical gas research
2023 Pilot / Observational Human H₂ therapy TabletsDrinking (HRW)

2023 · Sumbalová — The Effect of Adjuvant Therapy with Molecular Hydrogen on Endogenous Coenzyme Q10 Levels and Platelet Mitochondrial Bioenergetics in Patients with Non-Alcoholic Fatty Liver Disease.

International journal of molecular sciences
2023 Pilot / Observational Human H₂ therapy InhalationDrinking (HRW)

2023 · Wang — Effects of molecular hydrogen intervention on the gut microbiome in methamphetamine abusers with mental disorder.

Brain research bulletin
2022 Pilot / Observational Human H₂ therapy Drinking (HRW)

2022 · Dong — Short-Term Consumption of Hydrogen-Rich Water Enhances Power Performance and Heart Rate Recovery in Dragon Boat Athletes

International journal of environmental research and public health
2021 Pilot / Observational Human H₂ therapy Inhalation

2021 · Kaibori — Effect of hydrogen gas inhalation on patient QOL after hepatectomy: protocol for a randomised controlled trial

Trials
2020 Pilot / Observational Human H₂ therapy Inhalation

2020 · Hori et al. — Inhalation of molecular hydrogen increases breath acetone excretion during submaximal exercise: a randomized, single-blinded, placebo-controlled study.

Medical gas research
2020 Pilot / Observational Human H₂ therapy Drinking (HRW)

2020 · Javorac et al. — Case Report: Acute hydrotherapy with super-saturated hydrogen-rich water for ankle sprain in a professional athlete.

F1000Research
2019 Pilot / Observational Human H₂ therapy TabletsDrinking (HRW)

2019 · Javorac et al. — Case Report: Buccal administration of hydrogen-producing blend after a mild traumatic brain injury in a professional athlete.

F1000Research
2019 Pilot / Observational Human H₂ therapy Inhalation

2019 · Chen et al. — „Real world survey“ of hydrogen-controlled cancer: a follow-up report of 82 advanced cancer patients.

Medical gas research
2018 Pilot / Observational Human H₂ therapy Drinking (HRW)

2018 · Da Ponte — Effects of Hydrogen-Rich Water on Prolonged Intermittent Exercise

The Journal of sports medicine and physical fitness
2017 Pilot / Observational Human H₂ therapy Unspecified

2017 · Nakayama et al. — Possible clinical effects of molecular hydrogen (H₂) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation.

PloS one
2003 Pilot / Observational Human H₂ therapy Drinking (HRW)

2003 · Huang — Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water.

Kidney international
1998 Pilot / Observational

1998 · Ditto et al. — A one-hour active coping stressor reduces small bowel transit time in healthy young adults

Psychosomatic medicine
1990 Pilot / Observational

1990 · Makino — Measurement of Hepatic Blood Flow by the Hydrogen Gas Clearance Method: Experimental and Clinical Observations

Nihon Ika Daigaku zasshi
1985 Pilot / Observational

1985 · Mobassaleh et al. — Development of Carbohydrate Absorption in the Fetus and Neonate

Pediatrics
1984 Pilot / Observational

1984 · Read et al. — Is Raised Breath Hydrogen Related to the Pathogenesis of Pneumatosis Coli?

Gut
1984 Pilot / Observational

1984 · Sakiyama — The Cervical Blood Flow Using Hydrogen Gas Clearance Method

Nihon Sanka Fujinka Gakkai zasshi
2026 Mechanism / Preclinical Unspecified

2026 · Lei — Synergistic Stretching-Annealing and Salting-Out Enabling Ultrastrong, Ultratough Anisotropic Bacterial Cellulose Conductive Hydrogels for Bioelectric Sensors

Carbohydrate polymers
2025 Mechanism / Preclinical Unspecified

2025 · Negishi — The Rieske Iron-sulfur Protein Is a Primary Target of Molecular Hydrogen

Redox biology
2025 Mechanism / Preclinical Inhalation

2025 · Maier — Biomechanical Analysis of Biodegradable Magnesium, Zinc, and Polylactide Pins for Fixation of Radial Head Fractures

Journal of orthopaedic surgery and research
2025 Mechanism / Preclinical Drinking (HRW)

2025 · Seya — Hydrogen-rich Gas Enhances Mitochondrial Membrane Potential and Respiratory Function Recovery in Caco-2 Cells Post-ischemia-reperfusion Injury

Biochemical and biophysical research communications
2025 Mechanism / Preclinical Inhalation

2025 · Zhang — Hydrogen attenuates the senescence of adipose-derived stem cells and enhances their myogenic differentiation via modulation of the PRDX6/SIRT1/PGC-1α signaling pathway.

Human & experimental toxicology
2025 Mechanism / Preclinical Drinking (HRW)

2025 · Qiu — 3D printing combined with pH-induced 4D printed iron(III)-oxidized starch gels for controlled iron delivery and enhanced iron supplementation.

Carbohydrate polymers
2025 Mechanism / Preclinical Inhalation

2025 · Mancebo — Performance of Unmodified Mechanical Ventilators With 2% Hydrogen Gas Mixtures.

Respiratory care
2025 Mechanism / Preclinical Inhalation

2025 · Ji — Hydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis.

Advanced materials (Deerfield Beach, Fla.)
2024 Mechanism / Preclinical Unspecified

2024 · Benoit — d-aspartate, an amino-acid important for human health, supports anaerobic respiration in several Campylobacter species.

Research in microbiology
2024 Mechanism / Preclinical Drinking (HRW)

2024 · Lu et al. — Decoupling the Mutual Promotion of Inflammation and Oxidative Stress Mitigates Cognitive Decline and Depression-Like Behavior in rmTBI Mice by Promoting Myelin Renewal and Neuronal Survival

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
2023 Mechanism / Preclinical InhalationSaline / IV

2023 · Aokage — Attenuation of pulmonary damage in aged lipopolysaccharide-induced inflammation mice through continuous 2 % hydrogen gas inhalation: A potential therapeutic strategy for geriatric inflammation and survival

Experimental gerontology
2023 Mechanism / Preclinical Inhalation

2023 · Son — PdO-Nanoparticle-Embedded Carbon Nanotube Yarns for Wearable Hydrogen Gas Sensing Platforms with Fast and Sensitive Responses

ACS sensors
2023 Mechanism / Preclinical Inhalation

2023 · Iketani — H₂-induced transient upregulation of phospholipids with suppression of energy metabolism

Medical gas research
2023 Mechanism / Preclinical Bath / Topical

2023 · Sahoo — Hydrogen-producing Photocatalyst at Sunscreen for Athletes in Preventing and Healing Muscle-nerve-skin Injuries

Current topics in medicinal chemistry
2023 Mechanism / Preclinical Inhalation

2023 · Kopp — Long-term in vivo observations show biocompatibility and performance of ZX00 magnesium screws surface-modified by plasma-electrolytic oxidation in Göttingen miniature pigs

Acta biomaterialia
2023 Mechanism / Preclinical Unspecified

2023 · Yang — Molecular Hydrogen Promotes Adipose-derived Stem Cell Myogenic Differentiation via Regulation of Mitochondria

Current stem cell research & therapy
2022 Mechanism / Preclinical Unspecified

2022 · Di et al. — A Bio-Inspired, Ultra-Tough, High-Sensitivity, and Anti-Swelling Conductive Hydrogel Strain Sensor for Motion Detection and Information Transmission

Materials horizons
2022 Mechanism / Preclinical Unspecified

2022 · Sebastiampillai et al. — Using a High-Throughput, Whole-Cell Hydrogenase Assay to Identify Potential Small Molecule Inhibitors of [NiFe]-Hydrogenase

Metallomics : integrated biometal science
2022 Mechanism / Preclinical Drinking (HRW)

2022 · Asiain-Mira et al. — Hydrogen Production from Urea in Human Urine Using Segregated Systems

Water research
2022 Mechanism / Preclinical Inhalation

2022 · Catlett — Metabolic Synergy between Human Symbionts Bacteroides and Methanobrevibacter

Microbiology spectrum
2022 Mechanism / Preclinical InhalationSaline / IV

2022 · Ge — Microbial hydrogen economy alleviates colitis by reprogramming colonocyte metabolism and reinforcing intestinal barrier

Gut microbes
2022 Mechanism / Preclinical InhalationDrinking (HRW)

2022 · An — Gender-based differences in neuroprotective effects of hydrogen gas against intracerebral hemorrhage-induced depression

Neurochemistry international
2022 Mechanism / Preclinical Inhalation

2022 · Liu — In vivo microelectrode monitoring of real-time hydrogen concentration in different tissues of rats after inhaling hydrogen gas

Medical gas research
2021 Mechanism / Preclinical InhalationDrinking (HRW)

2021 · Yin et al. — Hydrogen Gas with Extracorporeal Cardiopulmonary Resuscitation Improves Survival after Prolonged Cardiac Arrest in Rats

Journal of translational medicine
2021 Mechanism / Preclinical Drinking (HRW)

2021 · LeBaron et al. — An H₂-Infused, Nitric Oxide-Producing Functional Beverage as a Neuroprotective Agent for TBIs and Concussions

Journal of integrative neuroscience
2021 Mechanism / Preclinical Drinking (HRW)

2021 · Ohta et al. — Reply to „Discussion: Drinking Hydrogen Water Enhances Endurance and Relieves Psychometric Fatigue: A Randomized, Double-Blind, Placebo-Controlled Study”

Canadian journal of physiology and pharmacology
2021 Mechanism / Preclinical Drinking (HRW)

2021 · Falster et al. — Discussion: Drinking Hydrogen Water Enhances Endurance and Relieves Psychometric Fatigue: A Randomized, Double-Blind, Placebo-Controlled Study

Canadian journal of physiology and pharmacology
2021 Mechanism / Preclinical Inhalation

2021 · Spanoghe et al. — Microbial Food from Light, Carbon Dioxide and Hydrogen Gas: Kinetic, Stoichiometric and Nutritional Potential of Three Purple Bacteria

Bioresource technology
2020 Mechanism / Preclinical Drinking (HRW)

2020 · Kwon — Antioxidant Activity of Hydrogen Water Mask Pack Composed of Gel-Type Emulsion and Hydrogen Generation Powder

International journal of molecular sciences
2020 Mechanism / Preclinical Inhalation

2020 · De Paepe — Bio-electrochemical COD Removal for Energy-efficient, Maximum and Robust Nitrogen Recovery from Urine through Membrane Aerated Nitrification

Water research
2020 Mechanism / Preclinical Inhalation

2020 · Sun — Photoactivated H₂ Nanogenerator for Enhanced Chemotherapy of Bladder Cancer

ACS nano
2020 Mechanism / Preclinical InhalationDrinking (HRW)

2020 · Ruaud — Syntrophy via Interspecies H₂ Transfer between Christensenella and Methanobrevibacter Underlies Their Global Cooccurrence in the Human Gut.

mBio
2020 Mechanism / Preclinical Unspecified

2020 · Ishihara — Molecular hydrogen suppresses superoxide generation in the mitochondrial complex I and reduced mitochondrial membrane potential.

Biochemical and biophysical research communications
2019 Mechanism / Preclinical Saline / IV

2019 · Kou et al. — Acid-responsive H₂-releasing Fe nanoparticles for safe and effective cancer therapy.

Journal of materials chemistry. B
2019 Mechanism / Preclinical Inhalation

2019 · Chen et al. — Inhaling Hydrogen Ameliorates Early Postresuscitation EEG Characteristics in an Asphyxial Cardiac Arrest Rat Model.

BioMed research international
2019 Mechanism / Preclinical Inhalation

2019 · Zhang — Hydrogen Gas Improves Photothermal Therapy of Tumor and Restrains the Relapse of Distant Dormant Tumor

Biomaterials
2019 Mechanism / Preclinical Unspecified

2019 · Amberg — Effect of Physical Cues of Altered Extract Media from Biodegradable Magnesium Implants on Human Gingival Fibroblasts

Acta biomaterialia
2019 Mechanism / Preclinical Unspecified

2019 · Kröninger — Energy Conservation in the Gut Microbe Methanomassiliicoccus luminyensis Is Based on Membrane-Bound Ferredoxin Oxidation Coupled to Heterodisulfide Reduction

The FEBS journal
2019 Mechanism / Preclinical Saline / IVDrinking (HRW)

2019 · Fan — Acid-Responsive H₂-Releasing 2D MgB₂ Nanosheet for Therapeutic Synergy and Side Effect Attenuation of Gastric Cancer Chemotherapy.

Advanced healthcare materials
2019 Mechanism / Preclinical Unspecified

2019 · Htun — Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model.

Scientific reports
2019 Mechanism / Preclinical Inhalation

2019 · Liu — In vitro and in vivo studies of Mg-30Sc alloys with different phase structure for potential usage within bone.

Acta biomaterialia
2018 Mechanism / Preclinical Inhalation

2018 · Perisin — Human gut microbe co-cultures have greater potential than monocultures for food waste remediation to commodity chemicals

Scientific reports
2018 Mechanism / Preclinical Unspecified

2018 · Kadnikov — Lignite coal burning seam in the remote Altai Mountains harbors a hydrogen-driven thermophilic microbial community

Scientific reports
2017 Mechanism / Preclinical InhalationSaline / IV

2017 · Watanabe — Protective Effect of Hydrogen Gas Inhalation on Muscular Damage Using a Mouse Hindlimb Ischaemia-Reperfusion Injury Model

Plastic and reconstructive surgery
2017 Mechanism / Preclinical Drinking (HRW)

2017 · Xing — Hydrogen Rich Water Attenuates Renal Injury and Fibrosis by Regulation of TGF-β-Induced Sirt1

Biological & pharmaceutical bulletin
2016 Mechanism / Preclinical Inhalation

2016 · Wang — Hydrogen Metabolism in Helicobacter pylori Plays a Role in Gastric Carcinogenesis through Facilitating CagA Translocation

mBio
2016 Mechanism / Preclinical Unspecified

2016 · Wolf — H₂ metabolism is widespread and diverse among human colonic microbes

Gut microbes
2015 Mechanism / Preclinical Unspecified

2015 · Chikan et al. — Atomic Insight into the Altered O6-Methylguanine-DNA Methyltransferase Protein Architecture in Gastric Cancer.

PloS one
2015 Mechanism / Preclinical Drinking (HRW)

2015 · Nkamga et al. — Diversity of human-associated Methanobrevibacter smithii isolates revealed by multispacer sequence typing.

Current microbiology
2013 Mechanism / Preclinical Inhalation

2013 · Wang et al. — A surface-eroding poly(1,3-trimethylene carbonate) coating for fully biodegradable magnesium-based stent applications.

Acta biomaterialia
2012 Mechanism / Preclinical Drinking (HRW)

2012 · Sun et al. — Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats.

Cardiovascular research
2010 Mechanism / Preclinical Inhalation

2010 · Wong — A biodegradable polymer-based coating to control the performance of magnesium alloy orthopaedic implants.

Biomaterials
2009 Mechanism / Preclinical Inhalation

2009 · Gray-Munro — The mechanism of deposition of calcium phosphate coatings from solution onto magnesium alloy AZ31.

Journal of biomedical materials research. Part A
2008 Mechanism / Preclinical Inhalation

2008 · Song — A role for IOP1 in mammalian cytosolic iron-sulfur protein biogenesis.

The Journal of biological chemistry
2008 Mechanism / Preclinical Unspecified

2008 · da Silva — Hydrogen as an energy source for the human pathogen Bilophila wadsworthia.

Antonie van Leeuwenhoek
2007 Mechanism / Preclinical Unspecified

2007 · Tovar et al. — A mitosome purification protocol based on percoll density gradients and its use in validating the mitosomal nature of Entamoeba histolytica mitochondrial Hsp70

Methods in molecular biology (Clifton, N.J.)
2002 Mechanism / Preclinical Inhalation

2002 · Happe — Hydrogenases in green algae: do they save the algae's life and solve our energy problems?

Trends in plant science
2002 Mechanism / Preclinical Unspecified

2002 · van der Giezen — Conserved properties of hydrogenosomal and mitochondrial ADP/ATP carriers: a common origin for both organelles.

The EMBO journal
2001 Mechanism / Preclinical Unspecified

2001 · Benchimol — Hydrogenosome morphological variation induced by fibronectin and other drugs in Trichomonas vaginalis and Tritrichomonas foetus.

Parasitology research
1999 Mechanism / Preclinical Inhalation

1999 · Tomita — Oxygen and hydrogen gas transport through living C6 cell suspensions is faster than that in dead cells.

Advances in experimental medicine and biology
1999 Mechanism / Preclinical Unspecified

1999 · Schneider — Anaerobic transformation of quercetin-3-glucoside by bacteria from the human intestinal tract.

Archives of microbiology
1994 Mechanism / Preclinical Inhalation

1994 · Florin — A Possible Role for Bile Acid in the Control of Methanogenesis and the Accumulation of Hydrogen Gas in the Human Colon

Journal of gastroenterology and hepatology
1993 Mechanism / Preclinical Inhalation

1993 · Scrimgeour — A Simplified Method for Deuterium/Hydrogen Isotope Ratio Measurements on Water Samples of Biological Origin

Biological mass spectrometry
1989 Mechanism / Preclinical Unspecified

1989 · Hörnsten — Effects of Escherichia coli spheroplast formation on assays of H₂ and adenosine triphosphate based ampicillin susceptibility tests.

Diagnostic microbiology and infectious disease
1989 Mechanism / Preclinical Inhalation

1989 · Heizmann — GasPak Plus versus Anaerocult A — two carbon dioxide/hydrogen systems for cultivation of anaerobes.

Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology