H2medicine
← All indications

Cancer (adjunct)

This category is strictly about H₂ as a possible complementary measure alongside standard cancer treatment — for example for quality of life or tolerability. H₂ is not a cancer treatment, and the evidence is early and limited.

Human studies on molecular hydrogen for Cancer (adjunct). This page collects the 169 studies catalogued in this area — 1 randomized trials, 15 pilot/observational studies and 55 reviews. Listed newest first.

2026 Review / Meta-analysis Inhalation

2026 · Seneff — The essential role of hydrogen gas recycling by gut microbes in reducing deuterium load in host mitochondria: is trimethylamine oxide a deuterium sensor?

Metabolomics : Official journal of the Metabolomic Society
2026 Review / Meta-analysis Unspecified

2026 · Shi — New progress in hydrogen-synergistic diagnostic and therapeutic nanoplatforms for tumor treatment.

Biomaterials science
2026 Review / Meta-analysis Inhalation

2026 · Nguyen Puente — Emerging Clinical Applications for Molecular Hydrogen

Respiratory care
2026 Review / Meta-analysis InhalationSaline / IVDrinking (HRW)

2026 · Nguyen — Advances in hydrogen delivery strategies for therapeutic applications

Advanced drug delivery reviews
2026 Review / Meta-analysis Inhalation

2026 · Pan — Stimuli-Responsive Hydrogen Production from Nanomaterials: Design, Regulation and Biomedical Applications

Advanced healthcare materials
2025 Review / Meta-analysis Unspecified

2025 · Xie — Mechanisms and Protective Strategies for Astronaut Skin Injury in Deep Space Environments

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
2025 Review / Meta-analysis Unspecified

2025 · Zhu — Molecular mechanisms associated with effects of hydrogen molecule in liver diseases: the review of current evidence

European journal of medical research
2025 Review / Meta-analysis Drinking (HRW)

2025 · Ye — Molecular hydrogen as a novel regulator of cellular pyroptosis: mechanistic insights and therapeutic implications

Molecular biology reports
2025 Review / Meta-analysis Unspecified

2025 · Brandi — Molecular hydrogen therapy: A „democratic” emerging strategy against aging and age-related diseases

Ageing research reviews
2025 Review / Meta-analysis Unspecified

2025 · Zajac — Molecular Hydrogen in the Treatment of Respiratory Diseases

International journal of molecular sciences
2025 Review / Meta-analysis Unspecified

2025 · Sahu — Activation, interaction and intimation of Nrf2 pathway and their mutational studies causing Nrf2 associated cancer

Biochimica et biophysica acta. Molecular basis of disease
2025 Review / Meta-analysis Inhalation

2025 · Li — Application Trends of Hydrogen-generating Nanomaterials for the Treatment of ROS-related Diseases

Biomaterials science
2025 Review / Meta-analysis Unspecified

2025 · Todorović — Hydrogen as an Innovative Nootropic in Health and Disease

Nutrition and health
2024 Review / Meta-analysis Unspecified

2024 · Khiji — The Therapeutic Application of Hydrogen in Cancer: The Potential and Challenges

Current pharmaceutical design
2023 Review / Meta-analysis Unspecified

2023 · Mohd Noor — A Systematic Review of Molecular Hydrogen Therapy in Cancer Management

Asian Pacific Journal of Cancer Prevention
2023 Review / Meta-analysis Inhalation

2023 · Johnsen et al. — Molecular Hydrogen Therapy — A Review on Clinical Studies and Outcomes

Molecules (Basel, Switzerland)
2023 Review / Meta-analysis InhalationSaline / IVBath / TopicalDrinking (HRW)

2023 · Saengsin et al. — Hydrogen Therapy as a Potential Therapeutic Intervention in Heart Disease: From the Past Evidence to Future Application

Cellular and molecular life sciences : CMLS
2022 Review / Meta-analysis Inhalation

2022 · Biswas — Electrocoagulation and electrooxidation technologies for pesticide removal from water or wastewater: A review

Chemosphere
2022 Review / Meta-analysis Unspecified

2022 · Fu — Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases

Oxidative medicine and cellular longevity
2022 Review / Meta-analysis Unspecified

2022 · Fu — Molecular hydrogen is a promising therapeutic agent for pulmonary disease

Journal of Zhejiang University. Science. B
2021 Review / Meta-analysis Unspecified

2021 · Tallima — Cell surface sphingomyelin: key role in cancer initiation, progression, and immune evasion.

Lipids in health and disease
2021 Review / Meta-analysis Unspecified

2021 · Hirano — Molecular Hydrogen as a Novel Antitumor Agent: Possible Mechanisms Underlying Gene Expression.

International journal of molecular sciences
2021 Review / Meta-analysis Unspecified

2021 · Hirano — Molecular Hydrogen as a Potential Clinically Applicable Radioprotective Agent.

International journal of molecular sciences
2021 Review / Meta-analysis Unspecified

2021 · Shi et al. — Hydrogen treatment: a novel option in liver diseases.

Clinical medicine (London, England)
2021 Review / Meta-analysis InhalationBath / Topical

2021 · Zhang et al. — Hydrogen Gas: A Novel Type of Antioxidant in Modulating Sexual Organs Homeostasis.

Oxidative medicine and cellular longevity
2021 Review / Meta-analysis InhalationSaline / IV

2021 · Sano et al. — Hydrogen Gas Therapy: From Preclinical Studies to Clinical Trials.

Current pharmaceutical design
2021 Review / Meta-analysis Unspecified

2021 · Shaik et al. — An Overview of Ovarian Cancer: Molecular Processes Involved and Development of Target-based Chemotherapeutics.

Current topics in medicinal chemistry
2021 Review / Meta-analysis Unspecified

2021 · Li et al. — Recent advances in studies of molecular hydrogen in the treatment of pancreatitis.

Life sciences
2021 Review / Meta-analysis Unspecified

2021 · Ohta — Direct Targets and Subsequent Pathways for Molecular Hydrogen to Exert Multiple Functions: Focusing on Interventions in Radical Reactions

Current pharmaceutical design
2021 Review / Meta-analysis Unspecified

2021 · Slezak et al. — Oxidative Stress and Pathways of Molecular Hydrogen Effects in Medicine

Current pharmaceutical design
2020 Review / Meta-analysis Unspecified

2020 · Hu — Molecular hydrogen: A potential radioprotective agent

Biomedicine & Pharmacotherapy
2020 Review / Meta-analysis Inhalation

2020 · Chen et al. — The future of cryoablation: An abscopal effect

Cryobiology
2020 Review / Meta-analysis InhalationBath / TopicalDrinking (HRW)

2020 · Kawamura et al. — Application of Molecular Hydrogen as a Novel Antioxidant in Sports Science

Oxidative medicine and cellular longevity
2019 Review / Meta-analysis Inhalation

2019 · Zhou — Micro/Nanomaterials-Augmented Hydrogen Therapy

Advanced Healthcare Materials
2019 Review / Meta-analysis Inhalation

2019 · Qian — Medical Application of Hydrogen in Hematological Diseases.

Oxidative medicine and cellular longevity
2019 Review / Meta-analysis InhalationSaline / IVDrinking (HRW)

2019 · LeBaron et al. — A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress.

Molecules (Basel, Switzerland)
2019 Review / Meta-analysis Unspecified

2019 · Kura et al. — Molecular hydrogen: potential in mitigating oxidative-stress-induced radiation injury.

Canadian journal of physiology and pharmacology
2019 Review / Meta-analysis Unspecified

2019 · Tao et al. — Molecular hydrogen: current knowledge on mechanism in alleviating free radical damage and diseases.

Acta biochimica et biophysica Sinica
2019 Review / Meta-analysis Inhalation

2019 · Wu — Hydrogen Gas from Inflammation Treatment to Cancer Therapy

ACS nano
2018 Review / Meta-analysis Unspecified

2018 · Morris — The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders

Sleep medicine reviews
2016 Review / Meta-analysis Unspecified

2016 · Zheng — Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis

Oxidative medicine and cellular longevity
2015 Review / Meta-analysis Unspecified

2015 · Ostojic — Molecular hydrogen: An inert gas turns clinically effective.

Annals of medicine
2015 Review / Meta-analysis Inhalation

2015 · Shimura et al. — Radiation occupational health interventions offered to radiation workers in response to the complex catastrophic disaster at the Fukushima Daiichi Nuclear Power Plant.

Journal of radiation research
2013 Review / Meta-analysis Saline / IVDrinking (HRW)

2013 · Qian — Hydrogen as a new class of radioprotective agent

International journal of biological sciences
2013 Review / Meta-analysis Drinking (HRW)

2013 · Takaki — Multiple hits, including oxidative stress, as pathogenesis and treatment target in non-alcoholic steatohepatitis (NASH)

International journal of molecular sciences
2013 Review / Meta-analysis Inhalation

2013 · Lucas — Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway

Molecular neurobiology
2012 Review / Meta-analysis Drinking (HRW)

2012 · Chuai — Molecular hydrogen and radiation protection

Free Radical Research
2012 Review / Meta-analysis Drinking (HRW)

2012 · Ohno et al. — Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases.

Oxidative medicine and cellular longevity
2012 Review / Meta-analysis Inhalation

2012 · Carbonero et al. — Contributions of the microbial hydrogen economy to colonic homeostasis.

Nature reviews. Gastroenterology & hepatology
2012 Review / Meta-analysis InhalationSaline / IVBath / TopicalDrinking (HRW)

2012 · Ohta — Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases.

Biochimica et biophysica acta
2011 Review / Meta-analysis InhalationSaline / IVBath / TopicalDrinking (HRW)

2011 · Ohta — Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications.

Current pharmaceutical design
2011 Review / Meta-analysis Unspecified

2011 · Noda et al. — The principle and the potential approach to ROS-dependent cytotoxicity by non-pharmaceutical therapies: optimal use of medical gases with antioxidant properties.

Current pharmaceutical design
2011 Review / Meta-analysis Unspecified

2011 · Naeem et al. — Defective protein folding and aggregation as the basis of neurodegenerative diseases: the darker aspect of proteins.

Cell biochemistry and biophysics
2009 Review / Meta-analysis InhalationDrinking (HRW)

2009 · Mahlen — Oral abscess caused by Campylobacter rectus: case report and literature review.

Journal of clinical microbiology
1996 Review / Meta-analysis Unspecified

1996 · Mehta — Magnetization Transfer Magnetic Resonance Imaging: A Clinical Review

Topics in magnetic resonance imaging : TMRI
2014 RCT Human H₂ therapy Saline / IV

2014 · Ishibashi et al. — Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study.

International immunopharmacology
2021 Pilot / Observational Human H₂ therapy Inhalation

2021 · Hirano — Protective effects of hydrogen gas inhalation on radiation-induced bone marrow damage in cancer patients: a retrospective observational study

Medical Gas Research
2021 Pilot / Observational Human H₂ therapy Inhalation

2021 · Chen — High-flow hydrogen inhalation might suppress the immune function of middle-aged participants: a self-controlled study

Medical gas research
2020 Pilot / Observational Human H₂ therapy Inhalation

2020 · Chen — Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system senescence in patients with advanced non-small cell lung cancer: a self-controlled study

Medical Gas Research
2020 Pilot / Observational Human H₂ therapy Inhalation

2020 · Chen et al. — Hydrogen therapy can be used to control tumor progression and alleviate the adverse events of medications in patients with advanced non-small cell lung cancer.

Medical gas research
2020 Pilot / Observational Human H₂ therapy Inhalation

2020 · Wang et al. — Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients.

QJM : monthly journal of the Association of Physicians
2019 Pilot / Observational Human H₂ therapy Inhalation

2019 · Akagi et al. — Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve prognosis.

Oncology reports
2019 Pilot / Observational Human H₂ therapy Inhalation

2019 · Chen et al. — „Real world survey“ of hydrogen-controlled cancer: a follow-up report of 82 advanced cancer patients.

Medical gas research
2018 Pilot / Observational Human H₂ therapy Inhalation

2018 · Akagi — Immunological Effect of Hydrogen Gas: Hydrogen Gas Improves Clinical Outcomes of Cancer Patients

Gan to kagaku ryoho. Cancer & chemotherapy
2015 Pilot / Observational Human H₂ therapy InhalationSaline / IVDrinking (HRW)

2015 · Ishibashi et al. — Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases.

Molecular medicine reports
2013 Pilot / Observational Human H₂ therapy Drinking (HRW)

2013 · Song et al. — Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome.

Journal of lipid research
2010 Pilot / Observational Human H₂ therapy Inhalation

2010 · Nakayama et al. — A Novel Bioactive Haemodialysis System Using Dissolved Dihydrogen (H₂) Produced by Water Electrolysis: A Clinical Trial

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
1994 Pilot / Observational

1994 · Parnes et al. — Chemotherapy-induced lactose intolerance in adults

Cancer
1994 Pilot / Observational

1994 · Nakahara et al. — Evaluation of tracheal mucosal blood flow during an extended radical operation for esophageal carcinoma

Surgery today
1990 Pilot / Observational

1990 · Makino — Measurement of Hepatic Blood Flow by the Hydrogen Gas Clearance Method: Experimental and Clinical Observations

Nihon Ika Daigaku zasshi
1988 Pilot / Observational

1988 · Toma et al. — Effect of Endocrine Treatment on Prostatic Blood Flow in Patients with Prostatic Adenocarcinoma

The Journal of urology
2026 Mechanism / Preclinical Inhalation

2026 · Sato — Optimization of lens size and ion source parameters for gas chromatography/mass spectrometry-based metabolomics using hydrogen as a carrier gas

Journal of chromatography. A
2026 Mechanism / Preclinical Unspecified

2026 · Němec — The Far Side of Carboranes: Anticancer Active Monocations and Ambiently Stable Dications

Angewandte Chemie (International ed. in English)
2026 Mechanism / Preclinical Unspecified

2026 · Bordoni — Ru-Based NSAIDs as Potential Anticancer Therapeutics

Molecules (Basel, Switzerland)
2026 Mechanism / Preclinical Inhalation

2026 · Li — MXene-Engineered MgB₂ Nanoprodrugs with Acid-Responsive Hydrogen Evolution for Cooperative Photothermal Cancer Ablation

ACS applied materials & interfaces
2026 Mechanism / Preclinical Drinking (HRW)

2026 · Yano — Electrolyzed Hydrogen Water Improves Chemosensitivity to Anticancer Drugs by Potently Suppressing Autophagy

Journal of cellular and molecular medicine
2026 Mechanism / Preclinical Unspecified

2026 · Zhang — Sub-nano Molybdenum Oxide Nanorings as Amplified Atomic Efficiency Sonosensitizers for Highly Efficient Sonodynamic Tumor Ablation

Nanoscale
2026 Mechanism / Preclinical InhalationDrinking (HRW)

2026 · Cao — A Hydrogen Generator Enhances Immunogenic Transarterial Chemoembolization in Hepatocellular Carcinoma

Journal of controlled release : official journal of the Controlled Release Society
2026 Mechanism / Preclinical Inhalation

2026 · Liang — Synergistic Calcium Overload and Hydrogen Release Potentiate Robust Antitumor Immunity

Advanced healthcare materials
2026 Mechanism / Preclinical InhalationDrinking (HRW)

2026 · Qin — Tumor Microenvironment-Responsive Hydrogen-Generating Zn-Doped ReZIF-8 Nanoplatform for Enhanced Tumor Suppression

Advanced healthcare materials
2025 Mechanism / Preclinical Saline / IVDrinking (HRW)

2025 · Jingxuan — Four-dimensional Data Independent Acquisition Proteomics and Metabolomics Reveal Mechanisms of Hydrogen-rich Water at Zusanli (ST36) Point against Triple-negative Breast Cancer in Mice

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
2025 Mechanism / Preclinical Unspecified

2025 · Chu — Hydrogen Enhanced Photothermal Therapy for Redox-regulated Tumor Apoptosis and Immune Reprogramming

Acta biomaterialia
2025 Mechanism / Preclinical Inhalation

2025 · Yin — Research on the Inhibitory Effect of Hydrogen Gas on Ovarian Cancer and Potential Mechanisms

European journal of medical research
2025 Mechanism / Preclinical Drinking (HRW)

2025 · Cao — Nanobiocatalyst-Driven Spatiotemporal Hydrogen Delivery Induces Dormancy Potentiated Catalytic Tumor Therapy.

ACS nano
2025 Mechanism / Preclinical Unspecified

2025 · Liu — Local Delivery of Molecular Hydrogen by Fluorinated Zeolitic Imidazole Framework Nanosheets Boosts Cancer Immunotherapy.

ACS applied materials & interfaces
2025 Mechanism / Preclinical Unspecified

2025 · Valizadeh — Integrating QSAR modeling, ADMET screening, molecular docking, and molecular dynamics simulations to identify potential MCF-7 inhibitors.

Computers in biology and medicine
2025 Mechanism / Preclinical Unspecified

2025 · Huang — Magnesium hydride-induced hydrogen therapy for enhanced sonodynamic therapy.

Materials horizons
2025 Mechanism / Preclinical Inhalation

2025 · Zhang — RNA-Seq Reveals the Mechanism of Synergistic Hydrogen-Chemotherapy Based on Active Magnesium Micromotors for Inhibiting Glioblastoma Recurrence by Modulating Tumor Microenvironment.

Small (Weinheim an der Bergstrasse, Germany)
2025 Mechanism / Preclinical Inhalation

2025 · Lin — Galvanic Cell Bipolar Microneedle Patches for Reversing Photoaging Wrinkles.

Advanced materials (Deerfield Beach, Fla.)
2025 Mechanism / Preclinical Unspecified

2025 · Zhang — Ternary Schottky Junction for Sonocatalytic Water Splitting in Gas-Immunotherapy-Mediated Cancer Treatment.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2025 Mechanism / Preclinical Unspecified

2025 · Chen — A Sustained H₂/Fluorouracil-Releasing Suppository for High-efficacy and Low-Toxicity Hydrogenochemotherapy of Colon Cancer.

Advanced healthcare materials
2025 Mechanism / Preclinical Inhalation

2025 · Yang — Manganese Galvanic Cells Intervene in Tumor Metabolism to Reinforce cGAS-STING Activation for Bidirectional Synergistic Hydrogen-Immunotherapy.

Advanced materials (Deerfield Beach, Fla.)
2025 Mechanism / Preclinical Inhalation

2025 · Hu — Hydrogen-Generating Magnesium Alloy Seed Strand Sensitizes Solid Tumors to Iodine-125 Brachytherapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2025 Mechanism / Preclinical Inhalation

2025 · Zhang — Living Therapeutics for Synergistic Hydrogen-Photothermal Cancer Treatment by Photosynthetic Bacteria.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2025 Mechanism / Preclinical Unspecified

2025 · Jiang — Engineering probiotic biohydrogen micro-factories to initiate reductive stress for boosting tumor vulnerability.

Biomaterials
2025 Mechanism / Preclinical Inhalation

2025 · Tian — Molecular hydrogen attenuates cisplatin-induced nephrotoxicity by modulating β-hydroxybutyrate metabolism

Molecular Biology Reports
2024 Mechanism / Preclinical Unspecified

2024 · Li — Modulating the Electronic Structure of MnNi₂S₃ Nanoelectrodes to Activate Pyroptosis for Electrocatalytic Hydrogen-Immunotherapy.

Advanced materials (Deerfield Beach, Fla.)
2024 Mechanism / Preclinical Unspecified

2024 · Meng — Hydrogen Therapy Reverses Cancer-Associated Fibroblasts Phenotypes and Remodels Stromal Microenvironment to Stimulate Systematic Anti-Tumor Immunity.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2023 Mechanism / Preclinical Unspecified

2023 · Agar — The Inhibition Mechanism of Pancreatic Ductal Adenocarcinoma via LXR Receptors: A Multifaceted Approach Integrating Molecular Docking, Molecular Dynamics and Post-MD Inter-Molecular Contact Analysis

Asian Pacific journal of cancer prevention : APJCP
2023 Mechanism / Preclinical Drinking (HRW)

2023 · Wu — Ultrasound-Driven Piezoelectrocatalytic Immunoactivation of Deep Tumor

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2023 Mechanism / Preclinical InhalationSaline / IV

2023 · Aokage — Attenuation of pulmonary damage in aged lipopolysaccharide-induced inflammation mice through continuous 2 % hydrogen gas inhalation: A potential therapeutic strategy for geriatric inflammation and survival

Experimental gerontology
2023 Mechanism / Preclinical Inhalation

2023 · Kiyoi — Intermittent environmental exposure to hydrogen prevents skin photoaging through reduction of oxidative stress

Geriatrics & gerontology international
2023 Mechanism / Preclinical Unspecified

2023 · Antonenko — Biological Activity of Novel Organotin Compounds with a Schiff Base Containing an Antioxidant Fragment

International journal of molecular sciences
2023 Mechanism / Preclinical Unspecified

2023 · Zhu — Two-Dimensional Mg₂Si Nanosheet-Enabled Sustained Hydrogen Generation for Improved Repair and Regeneration of Deeply Burned Skin

Advanced healthcare materials
2023 Mechanism / Preclinical Bath / Topical

2023 · Sahoo — Hydrogen-producing Photocatalyst at Sunscreen for Athletes in Preventing and Healing Muscle-nerve-skin Injuries

Current topics in medicinal chemistry
2023 Mechanism / Preclinical Saline / IV

2023 · Guo — Hydrogen suppresses oxidative stress by inhibiting the p38 MAPK signaling pathway in preeclampsia

Advances in clinical and experimental medicine : official organ Wroclaw Medical University
2022 Mechanism / Preclinical Unspecified

2022 · Yan et al. — Microbial Hydrogen „Manufactory” for Enhanced Gas Therapy and Self-Activated Immunotherapy via Reduced Immune Escape

Journal of nanobiotechnology
2022 Mechanism / Preclinical Unspecified

2022 · Geng et al. — Hydrogen Helps to Ameliorate Staphylococcus aureus-Induced Mastitis in Mice

International immunopharmacology
2022 Mechanism / Preclinical Unspecified

2022 · Yang — Magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer growth

Nature communications
2022 Mechanism / Preclinical Saline / IV

2022 · Li — Local Treatment of Hydrogen-Rich Saline Promotes Wound Healing In Vivo by Inhibiting Oxidative Stress via Nrf-2/HO-1 Pathway

Oxidative medicine and cellular longevity
2022 Mechanism / Preclinical Unspecified

2022 · Zhang — Metal-Organic-Framework-Based Hydrogen-Release Platform for Multieffective Helicobacter Pylori Targeting Therapy and Intestinal Flora Protective Capabilities

Advanced materials (Deerfield Beach, Fla.)
2021 Mechanism / Preclinical InhalationDrinking (HRW)

2021 · Yin et al. — Hydrogen Gas with Extracorporeal Cardiopulmonary Resuscitation Improves Survival after Prolonged Cardiac Arrest in Rats

Journal of translational medicine
2021 Mechanism / Preclinical Inhalation

2021 · Yuan et al. — In Situ Hydrogen Nanogenerator for Bimodal Imaging Guided Synergistic Photothermal/Hydrogen Therapies

Nanoscale
2021 Mechanism / Preclinical Unspecified

2021 · Bai et al. — A PdMo Bimetallene with Precise Wavelength Adjustment and Catalysis for Synergistic Photothermal Ablation and Hydrogen Therapy of Cancer at Different Depths

Journal of materials chemistry. B
2021 Mechanism / Preclinical Inhalation

2021 · Chu — Mechanism of hydrogen on cervical cancer suppression revealed by high-throughput RNA sequencing

Oncology reports
2021 Mechanism / Preclinical Unspecified

2021 · V — Investigations of Dianhydro-D-glucitol adsorbed on AuNPs surface: In silico and in vitro approach based on anticancer activity studies against A549 lung cancer cell lines

Journal of molecular recognition : JMR
2021 Mechanism / Preclinical Inhalation

2021 · Matsuura — Hydrogen Gas Therapy Attenuates Inflammatory Pathway Signaling in Septic Mice

The Journal of surgical research
2021 Mechanism / Preclinical Drinking (HRW)

2021 · Kato — Carcinostatic effects of alkanoyl ascorbate plus platinum nano-colloid and stabilization of the esterolytically resultant ascorbate by hydrogen

Human cell
2021 Mechanism / Preclinical Drinking (HRW)

2021 · Li et al. — Hydrogen-rich water attenuates the radiotoxicity induced by tritium exposure in vitro and in vivo

Journal of radiation research
2020 Mechanism / Preclinical Unspecified

2020 · Kato — Hydrogen-bubbled Platinum-colloid Suppresses Human Esophagus- or Tongue-carcinoma Cells with Intracellular Platinum-uptake and the Diminished Normal-cell Mortality

Human cell
2020 Mechanism / Preclinical Inhalation

2020 · Sun — Photoactivated H₂ Nanogenerator for Enhanced Chemotherapy of Bladder Cancer

ACS nano
2020 Mechanism / Preclinical Unspecified

2020 · Wang — NIR-Driven Water Splitting H₂ Production Nanoplatform for H₂-Mediated Cascade-Amplifying Synergetic Cancer Therapy

ACS applied materials & interfaces
2020 Mechanism / Preclinical Inhalation

2020 · Meng — Hydrogen Gas Represses the Progression of Lung Cancer via Down-regulating CD47

Bioscience reports
2020 Mechanism / Preclinical Unspecified

2020 · Bhattacharya — Effect of aggrecan degradation on the nanomechanics of hyaluronan in extra-fibrillar matrix of annulus fibrosus: A molecular dynamics investigation.

Journal of the mechanical behavior of biomedical materials
2020 Mechanism / Preclinical Drinking (HRW)

2020 · Yang — Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway.

BMC cancer
2019 Mechanism / Preclinical Saline / IV

2019 · Kou et al. — Acid-responsive H₂-releasing Fe nanoparticles for safe and effective cancer therapy.

Journal of materials chemistry. B
2019 Mechanism / Preclinical Inhalation

2019 · Zhang — Hydrogen Gas Improves Photothermal Therapy of Tumor and Restrains the Relapse of Distant Dormant Tumor

Biomaterials
2019 Mechanism / Preclinical Inhalation

2019 · Liu — Molecular Hydrogen Suppresses Glioblastoma Growth via Inducing the Glioma Stem-Like Cell Differentiation

Stem cell research & therapy
2019 Mechanism / Preclinical Inhalation

2019 · Wu — Hydrogen gas protects against ovariectomy-induced osteoporosis by inhibiting NF-κB activation.

Menopause (New York, N.Y.)
2019 Mechanism / Preclinical Saline / IVDrinking (HRW)

2019 · Fan — Acid-Responsive H₂-Releasing 2D MgB₂ Nanosheet for Therapeutic Synergy and Side Effect Attenuation of Gastric Cancer Chemotherapy.

Advanced healthcare materials
2019 Mechanism / Preclinical Inhalation

2019 · Yu — Hydrogen gas reduces HMGB1 release in lung tissues of septic mice in an Nrf2/HO-1-dependent pathway.

International immunopharmacology
2018 Mechanism / Preclinical Unspecified

2018 · Nobela — Efficient discrimination of natural stereoisomers of chicoric acid, an HIV-1 integrase inhibitor

Journal of photochemistry and photobiology. B, Biology
2018 Mechanism / Preclinical Inhalation

2018 · Dong — Protective effects of hydrogen gas against sepsis-induced acute lung injury via regulation of mitochondrial function and dynamics

International immunopharmacology
2018 Mechanism / Preclinical Unspecified

2018 · Vasiliev — Reducing Humidity Response of Gas Sensors for Medical Applications: Use of Spark Discharge Synthesis of Metal Oxide Nanoparticles

Sensors (Basel, Switzerland)
2018 Mechanism / Preclinical Saline / IV

2018 · Jiang — Therapeutic efficacy of hydrogen-rich saline alone and in combination with PI3K inhibitor in non-small cell lung cancer

Molecular medicine reports
2018 Mechanism / Preclinical Inhalation

2018 · Wang — Hydrogen gas inhibits lung cancer progression through targeting SMC3

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
2018 Mechanism / Preclinical Unspecified

2018 · Kadnikov — Lignite coal burning seam in the remote Altai Mountains harbors a hydrogen-driven thermophilic microbial community

Scientific reports
2018 Mechanism / Preclinical Unspecified

2018 · Zhang — Hydrogen ameliorates oxidative stress via PI3K-Akt signalling pathway in UVB-induced HaCaT cells

International journal of molecular medicine
2016 Mechanism / Preclinical Inhalation

2016 · Wang — Hydrogen Metabolism in Helicobacter pylori Plays a Role in Gastric Carcinogenesis through Facilitating CagA Translocation

mBio
2016 Mechanism / Preclinical Unspecified

2016 · An — Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents

European journal of medicinal chemistry
2016 Mechanism / Preclinical Saline / IV

2016 · Yang — Effects of hydrogen-rich medium on lipopolysaccharide-induced intestinal epithelial barrier dysfunction of human colon carcinoma cells

Zhonghua wei zhong bing ji jiu yi xue
2016 Mechanism / Preclinical Unspecified

2016 · Yang — Optically-Induced Cell Fusion on Cell Pairing Microstructures

Scientific reports
2016 Mechanism / Preclinical InhalationDrinking (HRW)

2016 · Muramatsu — Hydrogen-Rich Water Ameliorates Bronchopulmonary Dysplasia (BPD) in Newborn Rats

Pediatric pulmonology
2015 Mechanism / Preclinical Unspecified

2015 · Chen et al. — Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial dysfunction via an Nrf2/HO-1 signaling pathway.

International immunopharmacology
2015 Mechanism / Preclinical Unspecified

2015 · Chikan et al. — Atomic Insight into the Altered O6-Methylguanine-DNA Methyltransferase Protein Architecture in Gastric Cancer.

PloS one
2015 Mechanism / Preclinical Unspecified

2015 · Wang et al. — Michael acceptor in gambogic acid — Its role and application for potent antitumor agents.

Bioorganic & medicinal chemistry letters
2015 Mechanism / Preclinical InhalationDrinking (HRW)

2015 · Shi et al. — Hydrogen Therapy Reduces Oxidative Stress-associated Risks Following Acute and Chronic Exposure to High-altitude Environment.

Biomedical and environmental sciences : BES
2015 Mechanism / Preclinical Unspecified

2015 · Guan et al. — Effects of vitamin C, vitamin E, and molecular hydrogen on the placental function in trophoblast cells.

Archives of gynecology and obstetrics
2014 Mechanism / Preclinical Saline / IVDrinking (HRW)

2014 · Zhang et al. — Effect of hydrogen-rich water on acute peritonitis of rat models.

International immunopharmacology
2014 Mechanism / Preclinical Unspecified

2014 · Reis et al. — Clusianone, a naturally occurring nemorosone regioisomer, uncouples rat liver mitochondria and induces HepG2 cell death.

Chemico-biological interactions
2014 Mechanism / Preclinical Unspecified

2014 · Coban — DNA-binding studies and antitumor evaluation of novel water soluble organic pip and hpip analogs

Applied biochemistry and biotechnology
2013 Mechanism / Preclinical Unspecified

2013 · Yang et al. — Molecular hydrogen protects human lymphocyte AHH-1 cells against 12C6+ heavy ion radiation.

International journal of radiation biology
2012 Mechanism / Preclinical Saline / IV

2012 · Yang et al. — Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis.

Medical science monitor : international medical journal of experimental and clinical research
2012 Mechanism / Preclinical Bath / Topical

2012 · Kato et al. — Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes.

Journal of photochemistry and photobiology. B, Biology
2011 Mechanism / Preclinical Unspecified

2011 · Slaba — Variation in Lunar Neutron Dose Estimates

Radiation research
2011 Mechanism / Preclinical Inhalation

2011 · Terasaki — Hydrogen Therapy Attenuates Irradiation-Induced Lung Damage by Reducing Oxidative Stress

American journal of physiology. Lung cellular and molecular physiology
2011 Mechanism / Preclinical InhalationSaline / IV

2011 · Chuai — A Possible Prevention Strategy of Radiation Pneumonitis: Combine Radiotherapy with Aerosol Inhalation of Hydrogen-Rich Solution

Medical science monitor : international medical journal of experimental and clinical research
2011 Mechanism / Preclinical Unspecified

2011 · Lazzeroni — Production of Clinically Useful Positron Emitter Beams During Carbon Ion Deceleration

Physics in medicine and biology
2011 Mechanism / Preclinical InhalationDrinking (HRW)

2011 · Schoenfeld — Hydrogen Therapy May Reduce the Risks Related to Radiation-Induced Oxidative Stress in Space Flight

Medical hypotheses
2010 Mechanism / Preclinical Saline / IV

2010 · Qian — The hypothesis of an effective safe and novel radioprotective agent: hydrogen-rich solution.

The West Indian medical journal
2010 Mechanism / Preclinical Drinking (HRW)

2010 · Asada — Antitumor effects of nano-bubble hydrogen-dissolved water are enhanced by coexistent platinum colloid and the combined hyperthermia with apoptosis-like cell death.

Oncology reports
2010 Mechanism / Preclinical Unspecified

2010 · Kurisaki — Spontaneous adjustment mechanism in an RNA-binding protein: cooperation between energetic stabilization and target search enhancement.

Protein and peptide letters
2010 Mechanism / Preclinical Inhalation

2010 · Liu — Hydrogen therapy may be an effective and specific novel treatment for acute radiation syndrome.

Medical hypotheses
2009 Mechanism / Preclinical Unspecified

2009 · Zhu — A novel antibody fragment targeting HAb18G/CD147 with cytotoxicity and decreased immunogenicity.

Cancer biology & therapy
2009 Mechanism / Preclinical Unspecified

2009 · Kovala-Demertzi — Organotin meclofenamic complexes: Synthesis, crystal structures and antiproliferative activity of the first complexes of meclofenamic acid — novel anti-tuberculosis agents.

Journal of inorganic biochemistry
2008 Mechanism / Preclinical Drinking (HRW)

2008 · Ye — Inhibitory effect of electrolyzed reduced water on tumor angiogenesis.

Biological & pharmaceutical bulletin
2004 Mechanism / Preclinical Unspecified

2004 · Yu et al. — Studies on human breast cancer tissues with Raman microspectroscopy

Guang pu xue yu guang pu fen xi = Guang pu
1996 Mechanism / Preclinical Inhalation

1996 · Franić — Radiotoxicity of Tritiated Water and Tritiated Hydrogen

Arhiv za higijenu rada i toksikologiju
1983 Mechanism / Preclinical Inhalation

1983 · Peel — The fatty acyl chain composition of human normal and leukaemic lymphocytes and its modulation by specialised hydrogenation.

Leukemia research