Cancer (adjunct)
This category is strictly about H₂ as a possible complementary measure alongside standard oncological treatment — for example for quality of life or tolerability. H₂ is not a cancer treatment, and the evidence is early and limited. While around 169 papers touch on this topic, by far the largest part are mechanistic and preclinical investigations in cell and animal models as well as reviews. Robust human evidence is scarce: only a single randomized controlled trial and a few pilot and observational studies.
These human studies examine H₂ — mostly as inhalation or as hydrogen-rich water — not as a tumor therapy but as a supportive measure: they assessed, for example, quality of life, fatigue, side effects of chemotherapy or radiotherapy and individual immune markers.
Initial reports suggest a possible improvement in tolerability, but participant numbers are small, control groups are often missing and follow-up is short. A benefit is therefore not established. Molecular hydrogen is no substitute for oncological treatment and should be considered only in consultation with the treating medical team.
Human studies on molecular hydrogen for Cancer (adjunct). This page collects the 169 studies catalogued in this area — 1 randomized trials, 15 pilot/observational studies and 55 reviews. Listed newest first.
2026 · Seneff — The essential role of hydrogen gas recycling by gut microbes in reducing deuterium load in host mitochondria: is trimethylamine oxide a deuterium sensor?
This hypothesis paper proposes that the gut microbiome's recycling of molecular hydrogen plays a role in keeping mitochondria supplied with deuterium-depleted water — and that TMAO (a gut-derived metabolite elevated in many chronic diseases) may function as a marker for impaired deuterium management.
2026 · Shi — New progress in hydrogen-synergistic diagnostic and therapeutic nanoplatforms for tumor treatment.
This review maps the emerging field of hydrogen-synergistic diagnostic and therapeutic nanoplatforms (HSDT-NPs): engineered nanomaterials that combine H₂ therapy with other cancer treatment strategies to increase specificity and effectiveness at the tumor site.
2026 · Nguyen Puente — Emerging Clinical Applications for Molecular Hydrogen
Inhaled molecular hydrogen (H₂) has accumulated a growing body of encouraging clinical findings across neurological, cardiovascular, oncological and respiratory conditions — yet the evidence base remains constrained by small study sizes, inconsistent methodology, and a lack of standardised delivery systems.
2026 · Nguyen — Advances in hydrogen delivery strategies for therapeutic applications
Molecular hydrogen (H₂) has selective antioxidant, anti-inflammatory and anticancer properties — but getting it reliably to target tissues remains the central challenge limiting clinical use.
2026 · Pan — Stimuli-Responsive Hydrogen Production from Nanomaterials: Design, Regulation and Biomedical Applications
H₂ gas has broad therapeutic potential, but its low solubility and lack of targeted delivery limit clinical use — nanotechnology offers a solution through stimuli-responsive nanomaterials that produce H₂ on demand at disease sites.
2025 · Xie — Mechanisms and Protective Strategies for Astronaut Skin Injury in Deep Space Environments
This review summarises the current understanding of how deep space conditions — microgravity, ionising radiation, lunar dust, and microbiome disruption — damage astronaut skin, and what engineering and biomedical strategies are being developed to protect it.
2025 · Zhu — Molecular mechanisms associated with effects of hydrogen molecule in liver diseases: the review of current evidence
Oxidative stress and inflammation drive liver disease progression from inflammation to fibrosis and cancer — this review summarises how molecular hydrogen selectively neutralises harmful free radicals and modulates inflammatory signalling to potentially slow this cascade.
2025 · Brandi — Molecular hydrogen therapy: A „democratic” emerging strategy against aging and age-related diseases
Aging is the primary risk factor for cardiovascular disease, neurodegeneration, metabolic conditions, and cancer — this review proposes that molecular hydrogen, owing to its antioxidant, anti-inflammatory, and senescence-regulating properties, may offer a widely accessible strategy for slowing age-related processes.
2025 · Zajac — Molecular Hydrogen in the Treatment of Respiratory Diseases
This review compiles twenty years of research on molecular hydrogen in respiratory medicine, covering allergies, asthma, COPD, pulmonary fibrosis, lung injury, respiratory infections, and lung cancer.
2025 · Sahu — Activation, interaction and intimation of Nrf2 pathway and their mutational studies causing Nrf2 associated cancer
The Nrf2 transcription factor is the cell's master antioxidant switch — when Nrf2 functions correctly, it defends against cancer-driving oxidative damage; when mutated, it can paradoxically protect tumour cells from therapy.
2025 · Li — Application Trends of Hydrogen-generating Nanomaterials for the Treatment of ROS-related Diseases
Hydrogen-producing nanomaterials allow targeted, sustained delivery of H₂ directly to sites of disease — this review surveys how combining H₂ gas therapy with nanomedicine advances treatment of cancers, neurodegeneration, cardiovascular, liver, kidney, and skin diseases driven by excess reactive oxygen species (ROS).
2025 · Todorović — Hydrogen as an Innovative Nootropic in Health and Disease
Molecular hydrogen may improve executive function, alertness, and memory — this review surveys current evidence for H₂ as a nootropic (cognitive enhancer) in healthy individuals and in patients with neurodegenerative disorders, circadian disruption, and cancer.
2024 · Khiji — The Therapeutic Application of Hydrogen in Cancer: The Potential and Challenges
Cancer is frequently associated with oxidative stress and chronic inflammation, and this review examines molecular hydrogen (H₂) as a candidate supportive therapy that could help prevent cancer recurrence and reduce treatment side effects.
2023 · Mohd Noor — A Systematic Review of Molecular Hydrogen Therapy in Cancer Management
A systematic review of 27 studies classifies molecular hydrogen as a promising adjunctive cancer therapy.
2023 · Johnsen et al. — Molecular Hydrogen Therapy — A Review on Clinical Studies and Outcomes
This comprehensive review in Molecules analysed 81 identified clinical trials and 64 scientific publications on human studies of molecular hydrogen (H₂) therapy across a broad range of disease areas.
2023 · Saengsin et al. — Hydrogen Therapy as a Potential Therapeutic Intervention in Heart Disease: From the Past Evidence to Future Application
This comprehensive review in Cellular and Molecular Life Sciences synthesises in-vitro, animal, and clinical evidence for molecular hydrogen's protective effects in cardiovascular disease, covering its antioxidant, anti-inflammatory, and anti-apoptotic mechanisms.
2022 · Biswas — Electrocoagulation and electrooxidation technologies for pesticide removal from water or wastewater: A review
This review covers electrochemical methods — electrocoagulation and electrooxidation — for removing pesticides from water, and notes that H₂ gas is generated as a byproduct at the cathode during electrocoagulation.
2022 · Fu — Molecular hydrogen is a promising therapeutic agent for pulmonary disease
This review summarizes the growing body of evidence suggesting that molecular hydrogen can protect the lungs from a range of diseases — including acute lung injury, COPD, asthma, lung cancer, pulmonary hypertension, and pulmonary fibrosis — through its antioxidant, anti-inflammatory, and anti-apoptotic properties.
2021 · Tallima — Cell surface sphingomyelin: key role in cancer initiation, progression, and immune evasion.
This review examines how excess sphingomyelin (SM) on the outer surface of cancer cells enables tumors to evade the immune system, resist apoptosis, and ignore growth-suppressor signals.
2021 · Hirano — Molecular Hydrogen as a Novel Antitumor Agent: Possible Mechanisms Underlying Gene Expression.
This review surveys the growing evidence that molecular hydrogen (H₂) may act as an antitumor agent — not only by directly scavenging the most damaging reactive oxygen species (hydroxyl radicals), but also by regulating gene expression through indirect biological defense mechanisms.
2021 · Hirano — Molecular Hydrogen as a Potential Clinically Applicable Radioprotective Agent.
This review compiles animal and early clinical evidence showing that molecular hydrogen (H₂) can protect against radiation-induced damage — both in diagnostic and therapeutic radiation contexts — primarily by selectively scavenging the hydroxyl radicals (·OH) generated when ionizing radiation hits water molecules.
2021 · Shi et al. — Hydrogen treatment: a novel option in liver diseases.
Hydrogen therapy shows promise in a range of liver conditions — from fatty liver disease to hepatitis B and chemotherapy-induced liver dysfunction — acting through antioxidant, anti-inflammatory, and anti-apoptotic mechanisms.
2021 · Zhang et al. — Hydrogen Gas: A Novel Type of Antioxidant in Modulating Sexual Organs Homeostasis.
Molecular hydrogen (H₂) appears to benefit reproductive health in both males and females — from improving sperm motility and erectile function to protecting ovarian function and reducing uterine inflammation — acting primarily through antioxidant and anti-inflammatory mechanisms.
2021 · Sano et al. — Hydrogen Gas Therapy: From Preclinical Studies to Clinical Trials.
Hydrogen gas (H₂) has demonstrated broad therapeutic potential in preclinical and early clinical studies — from ischaemia-reperfusion injury to organ transplantation and emergency medicine — and appears safe, inexpensive, and easy to administer.
2021 · Shaik et al. — An Overview of Ovarian Cancer: Molecular Processes Involved and Development of Target-based Chemotherapeutics.
Ovarian cancer remains one of the deadliest gynaecological cancers, with most patients diagnosed at an advanced stage; this review surveys the molecular processes driving the disease and the development of targeted chemotherapeutics to address them.
2021 · Li et al. — Recent advances in studies of molecular hydrogen in the treatment of pancreatitis.
Pancreatitis — a serious inflammatory disease of the pancreas with high mortality — has recently attracted interest in molecular hydrogen (H₂) as a potential treatment, acting through antioxidant, anti-inflammatory, anti-apoptotic, and immune-modulatory mechanisms.
2021 · Ohta — Direct Targets and Subsequent Pathways for Molecular Hydrogen to Exert Multiple Functions: Focusing on Interventions in Radical Reactions
Molecular hydrogen (H₂) is not simply a passive antioxidant — it actively intervenes in radical chain reactions, modifying lipid peroxides and downstream signaling cascades.
2021 · Slezak et al. — Oxidative Stress and Pathways of Molecular Hydrogen Effects in Medicine
This review explains why molecular hydrogen (H₂) has unique advantages over conventional antioxidants: it selectively neutralises the most damaging reactive oxygen species while leaving beneficial ones intact.
2020 · Hu — Molecular hydrogen: A potential radioprotective agent
H₂ as a radioprotective agent: Most radiation damage arises from hydroxyl radicals (•OH) from the radiolysis of water — exactly the radical that H₂ selectively neutralizes.
2020 · Chen et al. — The future of cryoablation: An abscopal effect
This review on cryoablation for cancer treatment briefly mentions molecular hydrogen (H₂) as a potential combination partner — specifically because H₂ may rescue exhausted CD8+ T cells and thereby amplify the immune response triggered by tumour ablation.
2020 · Kawamura et al. — Application of Molecular Hydrogen as a Novel Antioxidant in Sports Science
This review surveys the evidence on molecular hydrogen (H₂) intake and exercise, covering all administration routes and focusing on exercise-induced oxidative stress.
2019 · Zhou — Micro/Nanomaterials-Augmented Hydrogen Therapy
Nanomedicine for hydrogen: H₂ works in oxidative-inflammatory diseases, but diffuses without direction and dissolves poorly in water.
2019 · Qian — Medical Application of Hydrogen in Hematological Diseases.
This review article surveys the clinical and basic research on molecular hydrogen in haematological diseases, including graft-versus-host disease (GvHD) after stem cell transplantation, and summarises H₂'s established antioxidant, anti-inflammatory, and anti-apoptotic properties.
2019 · LeBaron et al. — A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress.
Molecular hydrogen (H₂) has been studied in preclinical and clinical settings for a wide range of cardiovascular conditions linked to oxidative stress and inflammation.
2019 · Kura et al. — Molecular hydrogen: potential in mitigating oxidative-stress-induced radiation injury.
Molecular hydrogen (H₂) may help protect against radiation-induced oxidative damage by activating the body's own antioxidant defence systems — particularly the Nrf2 pathway — and reducing lipid peroxidation.
2019 · Tao et al. — Molecular hydrogen: current knowledge on mechanism in alleviating free radical damage and diseases.
Since molecular hydrogen was identified as a hydroxyl radical scavenger in 2007, beneficial effects have been documented in over 170 disease models and human conditions.
2019 · Wu — Hydrogen Gas from Inflammation Treatment to Cancer Therapy
This review surveys the emerging field of molecular hydrogen (H₂) therapy, from its anti-inflammatory mechanisms to its potential role in cancer treatment, with special focus on how nanomaterials can deliver H₂ more precisely to target sites.
2018 · Morris — The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders
This review proposes that oxidative stress, neuroinflammation, and mitochondrial dysfunction are shared drivers of sleep disturbances in chronic fatigue syndrome, bipolar disorder, and multiple sclerosis.
2016 · Zheng — Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis
This review summarises animal-based evidence suggesting that molecular hydrogen can reduce inflammatory cytokine release, oxidative stress, and organ damage in sepsis models, improving survival rates across brain, lung, liver, kidney, and intestinal tissues.
2015 · Ostojic — Molecular hydrogen: An inert gas turns clinically effective.
For decades considered biologically inert, molecular hydrogen (H₂) has in recent years accumulated clinical evidence — from metabolic diseases to chronic inflammation and cancer.
2015 · Shimura et al. — Radiation occupational health interventions offered to radiation workers in response to the complex catastrophic disaster at the Fukushima Daiichi Nuclear Power Plant.
Following the 2011 Fukushima nuclear disaster, a comprehensive set of occupational health measures protected emergency workers from radiation overexposure — fewer than 1% received doses above 100 mSv, and no deaths from radiation were reported.
2013 · Qian — Hydrogen as a new class of radioprotective agent
Molecular hydrogen (H₂) reduces radiation-induced oxidative damage by selectively neutralizing hydroxyl radicals — the main cause of ionizing radiation injury.
2013 · Takaki — Multiple hits, including oxidative stress, as pathogenesis and treatment target in non-alcoholic steatohepatitis (NASH)
Non-alcoholic steatohepatitis (NASH) progresses through multiple simultaneous pathways — including insulin resistance, gut microbiota, and oxidative stress — and conventional antioxidants have failed in long-term trials because they act non-selectively.
2013 · Lucas — Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway
Activation of the Toll-like receptor 4 (TLR4) pathway — triggered by environmental factors such as ozone, particulate matter, ionizing radiation, and LPS from bacteria — may underlie a wide spectrum of chronic inflammatory and neuropsychiatric diseases.
2012 · Chuai — Molecular hydrogen and radiation protection
Hydrogen (H₂) as radiation protection: ionizing radiation damages cells mainly via the hydroxyl radical (•OH) — exactly the radical H₂ selectively scavenges.
2012 · Ohno et al. — Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases.
This review surveys the research on molecular hydrogen (H₂) across 63 disease models and human diseases documented in the four and a half years after the landmark 2007 Nature Medicine paper.
2012 · Ohta — Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases.
This review by Shigeo Ohta — one of the founders of modern H₂ medicine — surveys the biological effects of molecular hydrogen across more than 38 diseases, physiological states, and clinical tests documented in the years following the 2007 Nature Medicine paper.
2011 · Ohta — Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications.
Since the landmark 2007 Nature Medicine paper demonstrating that molecular hydrogen (H₂) selectively neutralizes toxic hydroxyl radicals, the field of hydrogen medicine has grown rapidly.
2011 · Noda et al. — The principle and the potential approach to ROS-dependent cytotoxicity by non-pharmaceutical therapies: optimal use of medical gases with antioxidant properties.
Oxidative stress and reactive oxygen species (ROS) are implicated in many major diseases including inflammation, diabetes, glaucoma, cancer, ischemia, and neurodegeneration.
2011 · Naeem et al. — Defective protein folding and aggregation as the basis of neurodegenerative diseases: the darker aspect of proteins.
When proteins fail to fold correctly, they can form toxic aggregates — a process central to Alzheimer's, Parkinson's, Huntington's, ALS, and other neurodegenerative diseases.
2009 · Mahlen — Oral abscess caused by Campylobacter rectus: case report and literature review.
This case report and literature review describes the first documented case of a palate abscess caused by Campylobacter rectus in a patient with gastroesophageal adenocarcinoma.
1996 · Mehta — Magnetization Transfer Magnetic Resonance Imaging: A Clinical Review
Magnetization transfer (MT) is a magnetic resonance imaging technique that exploits the interaction between free water protons and protons bound to macromolecules — providing tissue contrast that reveals structural integrity beyond conventional T1, T2, and proton-density images.
2014 · Ishibashi et al. — Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study.
In 24 patients with rheumatoid arthritis (RA), intravenous infusion of H₂-enriched saline (500 mL/day, 5 days) significantly reduced disease activity scores (DAS28), lowered IL-6 and the oxidative damage marker 8-OHdG, and reduced MMP-3 — a marker of joint destruction — after 4 weeks.
2021 · Hirano — Protective effects of hydrogen gas inhalation on radiation-induced bone marrow damage in cancer patients: a retrospective observational study
Hydrogen inhalation mitigated bone marrow damage from irradiation — without weakening the tumor effect.
2021 · Chen — High-flow hydrogen inhalation might suppress the immune function of middle-aged participants: a self-controlled study
Twenty healthy adults who inhaled hydrogen at high flow rates for 2–4 hours daily over two weeks showed significant decreases in several immune cell populations, including T helper cells, NK cells, and gamma delta T cells.
2020 · Chen — Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system senescence in patients with advanced non-small cell lung cancer: a self-controlled study
Two weeks of hydrogen inhalation normalized aging-typical changes of the immune system in patients with advanced lung cancer.
2020 · Wang et al. — Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients.
A single 45-minute inhalation of hydrogen-containing steam (2.4 % H₂) reduced key inflammatory cytokines in airways of 10 asthma and 10 COPD patients — including monocyte chemotactic protein 1 in both groups and IL-8 in asthma.
2018 · Akagi — Immunological Effect of Hydrogen Gas: Hydrogen Gas Improves Clinical Outcomes of Cancer Patients
In a cohort of 55 Stage IV colorectal cancer patients, hydrogen gas inhalation reduced the proportion of exhausted immune cells (terminal PD-1⁺ CD8⁺ T cells) in 63.6% of patients, and patients who combined H₂ inhalation with nivolumab immunotherapy showed significantly longer overall survival than nivolumab alone.
2015 · Ishibashi et al. — Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases.
In three patients with psoriasis-associated arthritis and skin lesions, H₂ treatment (via saline infusion, inhalation, and/or high-concentration drinking water) reduced DAS28 and PASI scores, caused near-complete clearing of skin lesions, and lowered inflammatory cytokines (IL-6, IL-17, TNFα) in at least one patient.
2010 · Nakayama et al. — A Novel Bioactive Haemodialysis System Using Dissolved Dihydrogen (H₂) Produced by Water Electrolysis: A Clinical Trial
Adding dissolved molecular hydrogen to dialysis solution significantly reduced blood pressure and inflammatory markers in hemodialysis patients.
1994 · Parnes et al. — Chemotherapy-induced lactose intolerance in adults
Chemotherapy caused measurable lactose malabsorption in 30% of cancer patients, but symptomatic lactose intolerance developed in only 11%.
1994 · Nakahara et al. — Evaluation of tracheal mucosal blood flow during an extended radical operation for esophageal carcinoma
Extended radical surgery for esophageal cancer significantly reduced tracheal mucosal blood flow, from 40 to 13 ml/100 g per minute, while preserving the right bronchial artery appeared protective.
1990 · Makino — Measurement of Hepatic Blood Flow by the Hydrogen Gas Clearance Method: Experimental and Clinical Observations
Inhaled hydrogen gas serves as a highly accurate and minimally invasive tool for measuring liver blood flow in real time.
1988 · Toma et al. — Effect of Endocrine Treatment on Prostatic Blood Flow in Patients with Prostatic Adenocarcinoma
In 19 patients with prostatic adenocarcinoma, hydrogen gas clearance measurements showed that endocrine (hormone) therapy significantly increased blood flow to the prostate while reducing tumour volume — a finding suggesting that enhanced perfusion accompanies tumour cell deterioration under hormonal treatment.
2026 · Sato — Optimization of lens size and ion source parameters for gas chromatography/mass spectrometry-based metabolomics using hydrogen as a carrier gas
Global helium shortages are pushing analytical chemistry laboratories to adopt hydrogen gas as an alternative carrier gas for GC/MS metabolomics — but hydrogen causes unwanted ion-source reactions that alter fragmentation patterns.
2026 · Němec — The Far Side of Carboranes: Anticancer Active Monocations and Ambiently Stable Dications
Polyhedral carboranes — a class of boron-carbon cage molecules — are biologically stable and normally non-toxic; this in-vitro study shows that positively charged (cationic) carborane variants can display significant anticancer activity against human cancer cell lines, surpassing doxorubicin and cisplatin in potency.
2026 · Bordoni — Ru-Based NSAIDs as Potential Anticancer Therapeutics
Combining anti-inflammatory drugs (NSAIDs) with ruthenium metal centres creates novel compounds with promising anticancer activity in cell culture — and molecular hydrogen (H₂) is produced as a byproduct during synthesis, not as a therapeutic agent.
2026 · Li — MXene-Engineered MgB₂ Nanoprodrugs with Acid-Responsive Hydrogen Evolution for Cooperative Photothermal Cancer Ablation
Researchers engineered a nanoparticle system (MgB₂-Ti₃C₂Tₓ@PEG) that releases hydrogen gas specifically within the acidic tumor microenvironment and simultaneously converts near-infrared laser light into heat — combining hydrogen gas therapy with photothermal tumor ablation.
2026 · Yano — Electrolyzed Hydrogen Water Improves Chemosensitivity to Anticancer Drugs by Potently Suppressing Autophagy
Electrolyzed hydrogen water (EHW) suppressed autophagy — a recycling process cancer cells exploit to survive chemotherapy — and when combined with standard anticancer drugs (5-fluorouracil or paclitaxel), significantly reduced the viability of cervical and colorectal cancer cells in laboratory experiments.
2026 · Zhang — Sub-nano Molybdenum Oxide Nanorings as Amplified Atomic Efficiency Sonosensitizers for Highly Efficient Sonodynamic Tumor Ablation
Sub-nanometer molybdenum oxide nanorings (MoOx-S NRs) were designed as a dual-function nanosystem that generates both reactive oxygen species and hydrogen gas under ultrasound stimulation, aiming to kill cancer cells and modulate the tumor microenvironment.
2026 · Cao — A Hydrogen Generator Enhances Immunogenic Transarterial Chemoembolization in Hepatocellular Carcinoma
Adding a hydrogen-releasing material (nano-CaH₂) to the standard TACE (transarterial chemoembolization) procedure for liver cancer enabled local H₂ release that reduced tumor hypoxia, enhanced drug effectiveness, and activated anti-tumor immune responses — all demonstrated in animal models.
2026 · Liang — Synergistic Calcium Overload and Hydrogen Release Potentiate Robust Antitumor Immunity
A nanoplatform called Ca@CMPN combines calcium hydride and curcumin to simultaneously flood cancer cells with calcium ions (triggering immunogenic cell death) and release H₂ to reduce oxidative stress and reshape the immunosuppressive tumor microenvironment.
2025 · Jingxuan — Four-dimensional Data Independent Acquisition Proteomics and Metabolomics Reveal Mechanisms of Hydrogen-rich Water at Zusanli (ST36) Point against Triple-negative Breast Cancer in Mice
Injecting hydrogen-rich water into the Zusanli acupuncture point (ST36) significantly inhibited tumour growth and enhanced cancer-cell apoptosis in a mouse model of triple-negative breast cancer, according to this animal study combining proteomics and metabolomics.
2025 · Chu — Hydrogen Enhanced Photothermal Therapy for Redox-regulated Tumor Apoptosis and Immune Reprogramming
A novel nanomaterial platform combines hydrogen release with near-infrared photothermal heating to simultaneously destroy tumour cells and protect immune cells — demonstrating, for the first time, that H₂ can act as both a pro-oxidant in cancer cells and an antioxidant protector in immune cells within the same tumour environment.
2025 · Yin — Research on the Inhibitory Effect of Hydrogen Gas on Ovarian Cancer and Potential Mechanisms
Hydrogen gas inhibited ovarian cancer cell viability, migration, and invasion, promoted apoptosis, and reduced tumour size in both cell and animal experiments by modulating oxidative stress markers and suppressing key oncogenic proteins (HIF-1α, NF-κB p65).
2025 · Cao — Nanobiocatalyst-Driven Spatiotemporal Hydrogen Delivery Induces Dormancy Potentiated Catalytic Tumor Therapy.
Colorectal cancer cells can be pushed into a dormant, non-dividing state by molecular hydrogen (H₂) — and this dormancy makes them far more vulnerable to oxidative attack.
2025 · Liu — Local Delivery of Molecular Hydrogen by Fluorinated Zeolitic Imidazole Framework Nanosheets Boosts Cancer Immunotherapy.
A newly engineered nanomaterial can carry and locally release large amounts of molecular hydrogen (H₂) inside a tumour, while also amplifying the effect of immune checkpoint therapy.
2025 · Valizadeh — Integrating QSAR modeling, ADMET screening, molecular docking, and molecular dynamics simulations to identify potential MCF-7 inhibitors.
This computational study used mathematical models to predict which of 2,435 naphthoquinone chemical compounds might inhibit breast cancer cells — and used hydrogen-suppressed molecular graphs as part of the mathematical descriptor framework.
2025 · Huang — Magnesium hydride-induced hydrogen therapy for enhanced sonodynamic therapy.
Combining molecular hydrogen (H₂) released from magnesium hydride with ultrasound-activated cancer therapy (sonodynamic therapy, SDT) significantly improves anti-tumour efficacy and enhances the response to immune checkpoint inhibitors in mice.
2025 · Zhang — RNA-Seq Reveals the Mechanism of Synergistic Hydrogen-Chemotherapy Based on Active Magnesium Micromotors for Inhibiting Glioblastoma Recurrence by Modulating Tumor Microenvironment.
Glioblastoma (GBM) almost always returns after surgery — and a new approach using self-propelled magnesium micromotors that generate hydrogen gas locally and simultaneously deliver chemotherapy drug doxorubicin may significantly inhibit this recurrence.
2025 · Lin — Galvanic Cell Bipolar Microneedle Patches for Reversing Photoaging Wrinkles.
A microneedle patch containing magnesium-based bipolar electrodes generates microcurrents and releases hydrogen gas and magnesium ions directly in the skin via a galvanic cell reaction.
2025 · Zhang — Ternary Schottky Junction for Sonocatalytic Water Splitting in Gas-Immunotherapy-Mediated Cancer Treatment.
A specially designed nanoparticle catalyst (BPM) splits water inside tumours using ultrasound, generating both hydrogen and oxygen in situ.
2025 · Chen — A Sustained H₂/Fluorouracil-Releasing Suppository for High-efficacy and Low-Toxicity Hydrogenochemotherapy of Colon Cancer.
Combining hydrogen gas with the standard chemotherapy drug 5-fluorouracil in a rectal suppository achieved complete tumour eradication in a mouse colon-cancer model — while simultaneously protecting the intestinal tissue from chemotherapy-induced damage.
2025 · Yang — Manganese Galvanic Cells Intervene in Tumor Metabolism to Reinforce cGAS-STING Activation for Bidirectional Synergistic Hydrogen-Immunotherapy.
Manganese galvanic-cell nanostructures (MnG) generate hydrogen and manganese ions inside tumours by reacting with water, simultaneously activating a key innate-immunity pathway (cGAS-STING) and disrupting tumour glucose metabolism.
2025 · Hu — Hydrogen-Generating Magnesium Alloy Seed Strand Sensitizes Solid Tumors to Iodine-125 Brachytherapy.
An AZ31 magnesium-alloy brachytherapy seed strand (AMASS) implanted directly into tumours releases hydrogen gas alongside radioactive iodine-125 radiation, significantly enhancing tumour cell killing compared to radiation alone.
2025 · Zhang — Living Therapeutics for Synergistic Hydrogen-Photothermal Cancer Treatment by Photosynthetic Bacteria.
Living photosynthetic bacteria (Rhodobacter sphaeroides) were used as a self-powered, targeted platform that simultaneously generates hydrogen gas and converts near-infrared light into heat inside tumours.
2025 · Jiang — Engineering probiotic biohydrogen micro-factories to initiate reductive stress for boosting tumor vulnerability.
Probiotic bacteria (Enterobacter aerogenes) engineered into gel-based microcapsules produced continuous hydrogen inside tumours, inducing a state of „reductive stress“ — the opposite of oxidative stress — that disrupted cancer-cell metabolism and suppressed tumour growth.
2024 · Li — Modulating the Electronic Structure of MnNi₂S₃ Nanoelectrodes to Activate Pyroptosis for Electrocatalytic Hydrogen-Immunotherapy.
Specially engineered nanoelectrodes deliver molecular hydrogen directly to tumor cells via electrolysis, triggering a cell-death pathway called pyroptosis that also activates the immune system to fight cancer.
2024 · Meng — Hydrogen Therapy Reverses Cancer-Associated Fibroblasts Phenotypes and Remodels Stromal Microenvironment to Stimulate Systematic Anti-Tumor Immunity.
In cell and animal cancer models, a magnesium-based H₂-releasing implant reversed the immune-suppressive behaviour of cancer-associated fibroblasts, turning „cold“ tumors that resist the immune system into „hot“ ones that attract cancer-fighting T cells.
2023 · Agar — The Inhibition Mechanism of Pancreatic Ductal Adenocarcinoma via LXR Receptors: A Multifaceted Approach Integrating Molecular Docking, Molecular Dynamics and Post-MD Inter-Molecular Contact Analysis
A computational in-silico study investigated how natural compounds — Baicalein, Beta-Sitosterol, and Polydatin — might inhibit Liver X receptors (LXR), which play a role in the progression of pancreatic ductal adenocarcinoma (PDAC).
2023 · Wu — Ultrasound-Driven Piezoelectrocatalytic Immunoactivation of Deep Tumor
A novel nanotechnology platform uses ultrasound to drive piezoelectric tin disulfide nanosheets (SSN) to generate H₂ locally inside tumors and simultaneously deplete lactic acid — a dual strategy designed to reactivate immune cells against deep liver tumors in mice.
2023 · Aokage — Attenuation of pulmonary damage in aged lipopolysaccharide-induced inflammation mice through continuous 2 % hydrogen gas inhalation: A potential therapeutic strategy for geriatric inflammation and survival
In aged mice (21–23 months) with LPS-induced systemic inflammation, continuous inhalation of 2 % hydrogen gas for 24 hours reduced lung inflammation, lowered senescence-related markers, and improved survival — while having no measurable effect on LPS-induced liver injury.
2023 · Kiyoi — Intermittent environmental exposure to hydrogen prevents skin photoaging through reduction of oxidative stress
In a mouse model, nightly exposure to 1.3 % hydrogen gas for 6 weeks reduced UVA-induced skin aging: fewer senescent cells, less epidermal thickening, reduced melanogenesis, and less collagen degradation in the dermis.
2023 · Antonenko — Biological Activity of Novel Organotin Compounds with a Schiff Base Containing an Antioxidant Fragment
Researchers synthesised five new organotin(IV) complexes containing an antioxidant Schiff-base ligand and tested them for antioxidant activity and anti-cancer cell proliferation in vitro.
2023 · Zhu — Two-Dimensional Mg₂Si Nanosheet-Enabled Sustained Hydrogen Generation for Improved Repair and Regeneration of Deeply Burned Skin
A hydrogel dressing embedded with magnesium silicide nanosheets can continuously release molecular H₂ for about one week — and in animal and cell experiments, this sustained H₂ supply significantly accelerated healing of deep burn wounds without visible scarring.
2023 · Sahoo — Hydrogen-producing Photocatalyst at Sunscreen for Athletes in Preventing and Healing Muscle-nerve-skin Injuries
A theoretical concept paper proposes embedding a UV-absorbing photocatalyst into a hydrogel sunscreen that would continuously split sweat into H₂ — allowing athletes to absorb H₂ through the skin during sun exposure.
2023 · Guo — Hydrogen suppresses oxidative stress by inhibiting the p38 MAPK signaling pathway in preeclampsia
In a rat model of preeclampsia, hydrogen-rich saline significantly reduced inflammation markers, oxidative stress, and blood pressure-related damage — and the protective effect appears to work via inhibiting the p38 MAPK signaling pathway.
2022 · Yan et al. — Microbial Hydrogen „Manufactory” for Enhanced Gas Therapy and Self-Activated Immunotherapy via Reduced Immune Escape
Researchers used live photosynthetic bacteria (PSB) as a biological H₂ „factory” to release sustained amounts of hydrogen at tumour sites, selectively disrupting the reactive oxygen species balance in cancer cells while simultaneously stimulating an anti-tumour immune response.
2022 · Geng et al. — Hydrogen Helps to Ameliorate Staphylococcus aureus-Induced Mastitis in Mice
In a mouse model of bacterial mastitis, hydrogen-rich vitamin E glycerin (HR-VEG) applied topically to the mammary gland reduced tissue damage, inflammatory cytokines (TNF-α, IL-1β, IL-6), and bacterial load more effectively than regular vitamin E glycerin — by inhibiting the TLR2/Nod2-NF-κB/MAPK signalling cascade.
2022 · Yang — Magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer growth
Researchers implanted a magnesium-platinum galvanic rod directly into tumors in animal models; the resulting continuous hydrogen production suppressed tumor growth by disrupting mitochondrial function and neutralizing the acidic tumor environment.
2022 · Li — Local Treatment of Hydrogen-Rich Saline Promotes Wound Healing In Vivo by Inhibiting Oxidative Stress via Nrf-2/HO-1 Pathway
Applying hydrogen-rich saline directly to skin wounds in mice accelerated wound closure and reduced inflammation compared to regular saline, with the Nrf-2/HO-1 antioxidant pathway identified as the key mechanism.
2022 · Zhang — Metal-Organic-Framework-Based Hydrogen-Release Platform for Multieffective Helicobacter Pylori Targeting Therapy and Intestinal Flora Protective Capabilities
Researchers developed a pH-responsive nanoparticle system (palladium-hydrogen loaded into a zinc-based metal-organic framework, coated with an anti-inflammatory hydrogel) that, in both cell and animal experiments, selectively targets stomach inflammation sites, releases hydrogen to kill H.
2021 · Yin et al. — Hydrogen Gas with Extracorporeal Cardiopulmonary Resuscitation Improves Survival after Prolonged Cardiac Arrest in Rats
In a rat model of prolonged cardiac arrest, adding hydrogen gas (H₂) to extracorporeal cardiopulmonary resuscitation (ECPR) dramatically improved 4-hour survival: 78% with H₂ versus 22% without.
2021 · Yuan et al. — In Situ Hydrogen Nanogenerator for Bimodal Imaging Guided Synergistic Photothermal/Hydrogen Therapies
This nanotechnology study developed a nanoparticle system that generates hydrogen gas locally within tumors, combining hydrogen therapy with photothermal therapy (heat-based cancer treatment) to kill cancer cells.
2021 · Bai et al. — A PdMo Bimetallene with Precise Wavelength Adjustment and Catalysis for Synergistic Photothermal Ablation and Hydrogen Therapy of Cancer at Different Depths
This nanotechnology study synthesized a novel palladium-molybdenum (PdMo) bimetallene nanomaterial that simultaneously generates hydrogen gas and produces heat under near-infrared light, enabling combined anti-tumor therapy in mouse models.
2021 · Chu — Mechanism of hydrogen on cervical cancer suppression revealed by high-throughput RNA sequencing
H₂ inhalation suppressed the growth of cervical cancer cells in the laboratory and in a mouse xenograft model, apparently by switching off two key cancer-promoting proteins — HIF-1α and NF-κB p65.
2021 · V — Investigations of Dianhydro-D-glucitol adsorbed on AuNPs surface: In silico and in vitro approach based on anticancer activity studies against A549 lung cancer cell lines
This in-vitro and computational chemistry study examined how attaching a lung-cancer drug (Dianhydro-D-glucitol) to gold nanoparticles affects its anticancer behaviour against A549 lung cancer cells.
2021 · Matsuura — Hydrogen Gas Therapy Attenuates Inflammatory Pathway Signaling in Septic Mice
In a mouse cecal ligation and puncture (CLP) sepsis model, continuous H₂ inhalation improved 7-day survival from 40% to 75% and suppressed systemic and organ-level inflammatory signalling.
2021 · Kato — Carcinostatic effects of alkanoyl ascorbate plus platinum nano-colloid and stabilization of the esterolytically resultant ascorbate by hydrogen
This in-vitro chemistry study found that a combination of a fatty-acid ascorbate ester (Asc6Palm) plus platinum nanoparticles suppressed human oesophageal cancer cell viability.
2021 · Li et al. — Hydrogen-rich water attenuates the radiotoxicity induced by tritium exposure in vitro and in vivo
Hydrogen-rich water (HRW) reduces radioactive damage caused by tritiated water (HTO) — both in cultured human blood cells and in mice.
2020 · Kato — Hydrogen-bubbled Platinum-colloid Suppresses Human Esophagus- or Tongue-carcinoma Cells with Intracellular Platinum-uptake and the Diminished Normal-cell Mortality
In cell culture experiments, a combination of hydrogen nano-bubbles and platinum-polyvinylpyrrolidone colloid (PVP-Pt) more strongly suppressed the growth of human esophageal and tongue cancer cells than either agent alone — while showing comparatively less harm to non-malignant epithelial cells.
2020 · Sun — Photoactivated H₂ Nanogenerator for Enhanced Chemotherapy of Bladder Cancer
Researchers designed nanoparticles that generate H₂ gas inside cancer cells when activated by a 660 nm laser, finding in cell culture and mouse models that H₂ produced in this way significantly enhanced the efficacy of the chemotherapy drug gemcitabine against bladder cancer.
2020 · Wang — NIR-Driven Water Splitting H₂ Production Nanoplatform for H₂-Mediated Cascade-Amplifying Synergetic Cancer Therapy
This in-vitro and animal study presents a complex nanoparticle system that generates H₂ gas inside tumour cells via near-infrared (NIR) laser-driven water splitting, combining hydrogen gas therapy with photodynamic therapy, photothermal therapy, and chemodynamic therapy in a cascade approach against cancer.
2020 · Meng — Hydrogen Gas Represses the Progression of Lung Cancer via Down-regulating CD47
In lung cancer cell lines and a mouse tumour model, hydrogen gas treatment reduced the expression of CD47 — a „don't eat me“ signal that cancer cells use to evade immune destruction — and thereby inhibited cancer cell growth, invasion, migration, and promoted macrophage-mediated tumour cell clearance.
2020 · Bhattacharya — Effect of aggrecan degradation on the nanomechanics of hyaluronan in extra-fibrillar matrix of annulus fibrosus: A molecular dynamics investigation.
This computational study uses molecular dynamics simulations to examine how hydration — linked to aggrecan degradation — affects the nanoscale mechanical behaviour of hyaluronan in the outer ring of intervertebral discs.
2020 · Yang — Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway.
In endometrial cancer cell lines and a xenograft mouse model, hydrogen-rich water increased reactive oxygen species (ROS) in cancer cells, activated the NLRP3 inflammasome/GSDMD pyroptosis pathway, and suppressed tumour growth.
2019 · Kou et al. — Acid-responsive H₂-releasing Fe nanoparticles for safe and effective cancer therapy.
This preclinical study describes an ingenious drug-delivery strategy: iron nanoparticles coated with carboxymethyl cellulose that release molecular hydrogen (H₂) selectively inside the acidic tumour microenvironment, enabling targeted, imaging-guided cancer therapy in mice.
2019 · Zhang — Hydrogen Gas Improves Photothermal Therapy of Tumor and Restrains the Relapse of Distant Dormant Tumor
A biomimetic nanoparticle (mPDAB) that releases molecular hydrogen (H₂) locally in the tumor was combined with photothermal therapy (PTT) in a mouse breast cancer model, leading to complete elimination of primary tumors and suppression of distant dormant tumor regrowth.
2019 · Liu — Molecular Hydrogen Suppresses Glioblastoma Growth via Inducing the Glioma Stem-Like Cell Differentiation
In rat and mouse glioblastoma (GBM) models, daily inhalation of 67% hydrogen gas suppressed tumor growth, prolonged survival, and induced differentiation of cancer stem-like cells — reducing their self-renewal, proliferation, and invasive capacity.
2019 · Wu — Hydrogen gas protects against ovariectomy-induced osteoporosis by inhibiting NF-κB activation.
In mice with surgically induced estrogen deficiency (ovariectomy model of postmenopausal osteoporosis), inhalation of 60 % molecular hydrogen (H₂) markedly reduced bone loss.
2019 · Fan — Acid-Responsive H₂-Releasing 2D MgB₂ Nanosheet for Therapeutic Synergy and Side Effect Attenuation of Gastric Cancer Chemotherapy.
Researchers engineered a magnesium boride (MgB₂) nanosheet that releases molecular hydrogen in acidic environments (such as the stomach) and combined it with the chemotherapy drug doxorubicin in a gastric-tumor mouse model.
2019 · Yu — Hydrogen gas reduces HMGB1 release in lung tissues of septic mice in an Nrf2/HO-1-dependent pathway.
In septic mice (CLP model), 2 % hydrogen (H₂) gas inhalation reduced lung injury, improved survival, and decreased the release of HMGB1 — a late-phase danger signal in sepsis — through a pathway requiring the Nrf2 transcription factor and the enzyme HO-1.
2018 · Nobela — Efficient discrimination of natural stereoisomers of chicoric acid, an HIV-1 integrase inhibitor
This in-vitro chemistry study identifies and distinguishes two stereoisomers of chicoric acid — a plant-derived HIV-1 integrase inhibitor — using LC-MS, UV isomerisation, molecular dynamics, and quantum-chemical calculations.
2018 · Dong — Protective effects of hydrogen gas against sepsis-induced acute lung injury via regulation of mitochondrial function and dynamics
In a mouse model of sepsis-induced acute lung injury (ALI), inhaling 2% hydrogen gas improved lung oxygenation, preserved mitochondrial membrane potential and ATP production, and reduced tissue damage compared to untreated septic animals.
2018 · Vasiliev — Reducing Humidity Response of Gas Sensors for Medical Applications: Use of Spark Discharge Synthesis of Metal Oxide Nanoparticles
This engineering study develops improved tin dioxide (SnO₂) nanoparticle gas sensors that are less sensitive to humidity and can detect hydrogen gas, lactate vapour, and ammonia — biomarkers respectively of gut infections, stomach cancer, and H.
2018 · Jiang — Therapeutic efficacy of hydrogen-rich saline alone and in combination with PI3K inhibitor in non-small cell lung cancer
In cultured human lung cancer cells (A549 line), hydrogen-rich saline reduced proliferation and promoted apoptosis; combining it with the PI3K inhibitor LY294002 enhanced these effects further by suppressing the PI3K/Akt signalling pathway.
2018 · Wang — Hydrogen gas inhibits lung cancer progression through targeting SMC3
In lung cancer cell lines and a mouse xenograft model, hydrogen gas (H₂) inhibited cell viability, migration, and invasion while promoting apoptosis — apparently by downregulating SMC3, a chromosome condensation regulator.
2018 · Kadnikov — Lignite coal burning seam in the remote Altai Mountains harbors a hydrogen-driven thermophilic microbial community
In an underground coal fire site in the Altai Mountains, researchers identified thermophilic bacteria that survive by oxidising molecular hydrogen produced during coal combustion.
2018 · Zhang — Hydrogen ameliorates oxidative stress via PI3K-Akt signalling pathway in UVB-induced HaCaT cells
In human keratinocyte cells (HaCaT line) irradiated with UVB, hydrogen treatment reduced reactive oxygen species and oxidative damage markers while activating the PI3K/Akt/Nrf2/HO-1 protective cascade.
2016 · Wang — Hydrogen Metabolism in Helicobacter pylori Plays a Role in Gastric Carcinogenesis through Facilitating CagA Translocation
This animal and cell study shows that the bacterium Helicobacter pylori uses molecular hydrogen — produced by the gut microbiome — as an energy source to power delivery of its cancer-causing toxin CagA into stomach cells, promoting gastric cancer development in a gerbil model.
2016 · An — Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents
This medicinal chemistry study reports the synthesis and cancer-cell testing of new imidazo-pyridine compounds that inhibit tubulin polymerization — an approach to blocking cancer cell division.
2016 · Yang — Effects of hydrogen-rich medium on lipopolysaccharide-induced intestinal epithelial barrier dysfunction of human colon carcinoma cells
In a cell culture model of the intestinal epithelial barrier, hydrogen-rich medium protected Caco2 cells from lipopolysaccharide (LPS)-induced barrier disruption by improving cell viability, reducing cell injury, and partially restoring the expression and structure of tight-junction proteins claudin-1 and occludin.
2016 · Yang — Optically-Induced Cell Fusion on Cell Pairing Microstructures
This bioengineering paper reports a new technique called optically-induced cell fusion (OICF) that uses light-patterned virtual electrodes on a photoconductive film to selectively fuse paired cells with high efficiency.
2016 · Muramatsu — Hydrogen-Rich Water Ameliorates Bronchopulmonary Dysplasia (BPD) in Newborn Rats
Hydrogen-rich water given to pregnant and nursing rats reduced lung damage caused by a bacterial toxin in newborn animals.
2015 · Chen et al. — Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial dysfunction via an Nrf2/HO-1 signaling pathway.
In a mouse sepsis model, molecular hydrogen suppressed the inflammatory cascade and endothelial injury — both in cell culture and in live animals — by activating the Nrf2/HO-1 antioxidant pathway.
2015 · Chikan et al. — Atomic Insight into the Altered O6-Methylguanine-DNA Methyltransferase Protein Architecture in Gastric Cancer.
A missense mutation at codon 151 of the DNA-repair protein MGMT — found in nearly 40 % of tested gastric-cancer tissue samples — causes major structural disruption of the protein's active site, as shown by molecular dynamics simulation.
2015 · Wang et al. — Michael acceptor in gambogic acid — Its role and application for potent antitumor agents.
Gambogic acid (GA), a natural compound with broad anti-cancer activity, contains a highly reactive Michael acceptor at its C-10 position that limits clinical use by reacting non-selectively with biological nucleophiles.
2015 · Shi et al. — Hydrogen Therapy Reduces Oxidative Stress-associated Risks Following Acute and Chronic Exposure to High-altitude Environment.
This theoretical paper proposes that inhaling low-dose H₂ gas or drinking hydrogen-saturated water could prevent and treat mountain sickness by counteracting the oxidative stress caused by high-altitude low-oxygen and high-UV conditions.
2015 · Guan et al. — Effects of vitamin C, vitamin E, and molecular hydrogen on the placental function in trophoblast cells.
In cultured trophoblast cell lines, high doses of vitamins C and E reduced cell viability and increased the pro-inflammatory cytokine TNF-α — whereas molecular hydrogen (H₂) at equivalent concentrations did neither, suggesting a more favourable safety profile for H₂ as an antioxidant in placental biology.
2014 · Zhang et al. — Effect of hydrogen-rich water on acute peritonitis of rat models.
This animal study tested hydrogen-rich water (HRW) in three different rat models of acute peritonitis and found consistent protective effects: lower inflammatory markers, reduced oxidative damage, and decreased NF-κB expression in peritoneal tissue.
2014 · Reis et al. — Clusianone, a naturally occurring nemorosone regioisomer, uncouples rat liver mitochondria and induces HepG2 cell death.
This in-vitro and animal study characterised clusianone — a natural plant compound — as a mitochondrial uncoupler and anticancer agent, where hydrogen appears only as a structural feature of the molecule (an intramolecular hydrogen bond), not as a therapeutic substance.
2014 · Coban — DNA-binding studies and antitumor evaluation of novel water soluble organic pip and hpip analogs
Two newly synthesized water-soluble organic compounds (pip and hpip analogs) were tested for DNA-binding and antitumor activity in cell culture.
2013 · Yang et al. — Molecular hydrogen protects human lymphocyte AHH-1 cells against 12C6+ heavy ion radiation.
In a cell culture experiment, molecular hydrogen (H₂) reduced reactive oxygen species (ROS), attenuated apoptosis, and alleviated cell cycle arrest in human lymphocyte cells exposed to heavy-ion radiation — a type of ionising radiation used in cancer radiotherapy and relevant to space travel.
2012 · Yang et al. — Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis.
Ionizing radiation depletes the immune system by triggering apoptosis (programmed cell death) in immune cells — a major problem in radiation therapy and radiological accidents.
2012 · Kato et al. — Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes.
UVA radiation from sunlight damages skin cells, promotes wrinkle formation, and reduces collagen production — primarily via oxidative stress from reactive oxygen species.
2011 · Slaba — Variation in Lunar Neutron Dose Estimates
This theoretical physics study calculates how much albedo neutrons — reflected cosmic rays — contribute to radiation exposure on the lunar surface, and shows that hydrogen-rich shielding materials such as polyethylene can reduce that exposure.
2011 · Terasaki — Hydrogen Therapy Attenuates Irradiation-Induced Lung Damage by Reducing Oxidative Stress
In irradiated human lung cells and in mice given whole-thorax irradiation, molecular hydrogen (H₂) — delivered as H₂-rich PBS, H₂-enriched drinking water, or 3% H₂ inhalation — significantly reduced oxidative stress markers, apoptosis, and lung fibrosis.
2011 · Chuai — A Possible Prevention Strategy of Radiation Pneumonitis: Combine Radiotherapy with Aerosol Inhalation of Hydrogen-Rich Solution
This theoretical paper proposes that combining radiotherapy with aerosol inhalation of hydrogen-rich physiological saline could reduce radiation pneumonitis — a serious complication of lung cancer radiotherapy — by exploiting H₂'s ability to scavenge the hydroxyl radicals that cause most radiation-induced cell damage.
2011 · Lazzeroni — Production of Clinically Useful Positron Emitter Beams During Carbon Ion Deceleration
This radiation physics study models how to produce high-energy carbon-11 (¹¹C) fragments from a primary ¹²C beam for simultaneous cancer treatment and PET imaging — and finds that hydrogen-rich materials such as liquid hydrogen and polyethylene are the most efficient decelerators for this process.
2011 · Schoenfeld — Hydrogen Therapy May Reduce the Risks Related to Radiation-Induced Oxidative Stress in Space Flight
This hypothesis paper proposes that astronauts exposed to cosmic radiation during space missions could benefit from H₂ therapy — via inhalation or hydrogen-rich drinking water — to counteract the oxidative and DNA damage caused by cosmic radiation.
2010 · Qian — The hypothesis of an effective safe and novel radioprotective agent: hydrogen-rich solution.
This theory paper proposes that hydrogen-rich saline could serve as a safe radioprotective agent — protecting cells from ionising radiation damage by selectively scavenging hydroxyl radicals.
2010 · Asada — Antitumor effects of nano-bubble hydrogen-dissolved water are enhanced by coexistent platinum colloid and the combined hyperthermia with apoptosis-like cell death.
This laboratory (in-vitro/animal) study tested whether hydrogen-dissolved water — especially in combination with platinum colloid and mild heat (42 °C) — could inhibit the growth of tumour cells.
2010 · Kurisaki — Spontaneous adjustment mechanism in an RNA-binding protein: cooperation between energetic stabilization and target search enhancement.
This computational biology study used molecular dynamics simulation to analyse structural changes in an RNA-binding protein (NOVA) after it dissociates from its RNA target.
2010 · Liu — Hydrogen therapy may be an effective and specific novel treatment for acute radiation syndrome.
This hypothesis paper proposes that inhaled molecular hydrogen (H₂) could be an effective treatment for acute radiation syndrome (ARS) — the life-threatening condition caused by high-dose whole-body irradiation.
2009 · Zhu — A novel antibody fragment targeting HAb18G/CD147 with cytotoxicity and decreased immunogenicity.
This in-vitro study describes the engineering of a humanized antibody fragment targeting CD147, a protein overexpressed on hepatocellular carcinoma cells, to reduce immunogenicity while maintaining cytotoxic activity.
2009 · Kovala-Demertzi — Organotin meclofenamic complexes: Synthesis, crystal structures and antiproliferative activity of the first complexes of meclofenamic acid — novel anti-tuberculosis agents.
This in-vitro chemistry study synthesized and characterized organotin complexes of meclofenamic acid and tested them against cancer cell lines and Mycobacterium tuberculosis.
2008 · Ye — Inhibitory effect of electrolyzed reduced water on tumor angiogenesis.
This in-vitro study found that electrolyzed reduced water (ERW) reduced VEGF (vascular endothelial growth factor) gene expression and protein secretion in a human lung adenocarcinoma cell line, and inhibited in vitro formation of vascular tubules.
2004 · Yu et al. — Studies on human breast cancer tissues with Raman microspectroscopy
This in-vitro spectroscopy study uses Raman microspectroscopy to identify molecular differences between normal and malignant human breast tissue samples, finding changes in nucleic acids, proteins, and lipids in cancer tissue.
1996 · Franić — Radiotoxicity of Tritiated Water and Tritiated Hydrogen
Tritiated water (HTO) is far more radiotoxic than tritiated hydrogen gas (HT): inhaling tritiated H₂ gas leads to partial oxidation into HTO in the lungs, meaning the effective dose is higher than previously assumed — and the official toxicity ratio of 1:25,000 (HT vs.
1983 · Peel — The fatty acyl chain composition of human normal and leukaemic lymphocytes and its modulation by specialised hydrogenation.
The fatty acid profiles of lymphocytes from chronic lymphocytic leukaemia (CLL) patients show a characteristic pattern — higher oleic acid, lower arachidonic acid — consistent with other cancer cell types.