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Unspecified

Studies where the source did not state how H₂ was administered — the delivery route is unknown or unreported. Collected here so nothing is dropped from the overview.

Human studies on molecular hydrogen given by Unspecified. This page collects the 234 studies using this route — 2 randomized trials, 17 pilot/observational studies and 83 reviews. Listed newest first.

2026 Review / Meta-analysis Unspecified

2026 · Dumbuya — The protective effects of molecular hydrogen in sepsis-associated encephalopathy: current status.

European journal of pharmacology

2026 Review / Meta-analysis Unspecified

2026 · Shi — New progress in hydrogen-synergistic diagnostic and therapeutic nanoplatforms for tumor treatment.

Biomaterials science

2026 Review / Meta-analysis Unspecified

2026 · Ostojic — Revisiting molecular hydrogen signaling in mitochondria: Is the Rieske protein the entry point or a downstream sentinel?

Redox biology

2026 Review / Meta-analysis Unspecified

2026 · Paparella — Medical Gases as Emerging Regulators of Paediatric Endocrine and Neurodevelopmental Pathways: A Mini-Review

Acta paediatrica (Oslo, Norway : 1992)

2026 Review / Meta-analysis Unspecified

2026 · Viana — Molecular hydrogen and kidney diseases: a scoping review based on scientometry and data analytics

Medical gas research

2025 Review / Meta-analysis Unspecified

2025 · Xie — Mechanisms and Protective Strategies for Astronaut Skin Injury in Deep Space Environments

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

2025 Review / Meta-analysis Unspecified

2025 · Kornieieva — Exploring the Potential of Molecular Hydrogen in Different Heart Failure Models: A Review

International journal of molecular sciences

2025 Review / Meta-analysis Unspecified

2025 · Xu — Innovations in peritoneal dialysis fluid: biocompatible formulations and expanded therapeutic applications

Renal failure

2025 Review / Meta-analysis Unspecified

2025 · Zhu — Molecular mechanisms associated with effects of hydrogen molecule in liver diseases: the review of current evidence

European journal of medical research

2025 Review / Meta-analysis Unspecified

2025 · Li — Delivery of Molecular Hydrogen for Precision Immunomodulation: Mechanisms, Detection Methods, and Applications

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2025 Review / Meta-analysis Unspecified

2025 · Brandi — Molecular hydrogen therapy: A „democratic” emerging strategy against aging and age-related diseases

Ageing research reviews

2025 Review / Meta-analysis Unspecified

2025 · Zajac — Molecular Hydrogen in the Treatment of Respiratory Diseases

International journal of molecular sciences

2025 Review / Meta-analysis Unspecified

2025 · Sahu — Activation, interaction and intimation of Nrf2 pathway and their mutational studies causing Nrf2 associated cancer

Biochimica et biophysica acta. Molecular basis of disease

2025 Review / Meta-analysis Unspecified

2025 · Ying — Molecular hydrogen: Mechanism against oxidative stress and application in periodontitis: A review

Medicine

2025 Review / Meta-analysis Unspecified

2025 · Neykhonji — Exploring the Potential of H₂ Therapy in Reducing Surgical Complications: A Review on Anti-inflammatory, Antioxidant, and Anti-fibrotic Mechanisms

Current pharmaceutical design

2025 Review / Meta-analysis Unspecified

2025 · Todorović — Hydrogen as an Innovative Nootropic in Health and Disease

Nutrition and health

2024 Review / Meta-analysis Unspecified

2024 · Slezák — New Possibilities of the Prevention and Treatment of Cardiovascular Pathologies: The Potential of Molecular Hydrogen in the Reduction of Oxidative Stress

Physiological research

2024 Review / Meta-analysis Unspecified

2024 · Wu — Evolution of Therapeutic Strategy Based on Oxidant-Antioxidant Balance for Fuchs Endothelial Corneal Dystrophy

The ocular surface

2024 Review / Meta-analysis Unspecified

2024 · Kura — The Protective Role of Molecular Hydrogen in Ischemia/Reperfusion Injury

International journal of molecular sciences

2024 Review / Meta-analysis Unspecified

2024 · Zheng — Potential Role of Molecular Hydrogen Therapy on Oxidative Stress and Redox Signaling in Chronic Kidney Disease

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024 Review / Meta-analysis Unspecified

2024 · Hu — The Molecular Biological Mechanism of Hydrogen Therapy and Its Application in Spinal Cord Injury

Drug design, development and therapy

2024 Review / Meta-analysis Unspecified

2024 · Khiji — The Therapeutic Application of Hydrogen in Cancer: The Potential and Challenges

Current pharmaceutical design

2024 Review / Meta-analysis Unspecified

2024 · Chen — The Role of Hydrogen in the Prevention and Treatment of Coronary Atherosclerotic Heart Disease

European journal of pharmacology

2023 Review / Meta-analysis Unspecified

2023 · Mohd Noor — A Systematic Review of Molecular Hydrogen Therapy in Cancer Management

Asian Pacific Journal of Cancer Prevention

2023 Review / Meta-analysis Unspecified

2023 · Artamonov — Molecular Hydrogen: From Molecular Effects to Stem Cells Management and Tissue Regeneration

Antioxidants (Basel)

2023 Review / Meta-analysis Unspecified

2023 · He et al. — The Role of Hydrogen Therapy in Alzheimer's Disease Management: Insights into Mechanisms, Administration Routes, and Future Challenges

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Review / Meta-analysis Unspecified

2023 · Bellucci et al. — Novel Therapeutic Approaches Based on the Pathological Role of Gut Dysbiosis on the Link Between Non-Alcoholic Fatty Liver Disease and Insulin Resistance

European review for medical and pharmacological sciences

2023 Review / Meta-analysis Unspecified

2023 · Ichikawa et al. — The Overlooked Benefits of Hydrogen-Producing Bacteria

Medical gas research

2023 Review / Meta-analysis Unspecified

2023 · Wu et al. — Molecular Hydrogen: An Emerging Therapeutic Medical Gas for Brain Disorders

Molecular neurobiology

2022 Review / Meta-analysis Unspecified

2022 · Fu — Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases

Oxidative medicine and cellular longevity

2022 Review / Meta-analysis Unspecified

2022 · Zhang et al. — Molecular Hydrogen Is a Potential Protective Agent in the Management of Acute Lung Injury

Molecular medicine (Cambridge, Mass.)

2022 Review / Meta-analysis Unspecified

2022 · Ahmad et al. — Narrative on Hydrogen Therapy and its Clinical Applications: Safety and Efficacy

Current pharmaceutical design

2022 Review / Meta-analysis Unspecified

2022 · Fu — Molecular hydrogen is a promising therapeutic agent for pulmonary disease

Journal of Zhejiang University. Science. B

2021 Review / Meta-analysis Unspecified

2021 · Qi — Perspective of Molecular Hydrogen in the Treatment of Sepsis

Current Pharmaceutical Design

2021 Review / Meta-analysis Unspecified

2021 · Tallima — Cell surface sphingomyelin: key role in cancer initiation, progression, and immune evasion.

Lipids in health and disease

2021 Review / Meta-analysis Unspecified

2021 · Alwazeer — Combating Oxidative Stress and Inflammation in COVID-19 by Molecular Hydrogen Therapy: Mechanisms and Perspectives.

Oxidative medicine and cellular longevity

2021 Review / Meta-analysis Unspecified

2021 · Oren — Amyloid β structural polymorphism, associated toxicity and therapeutic strategies.

Cellular and molecular life sciences : CMLS

2021 Review / Meta-analysis Unspecified

2021 · Hirano — Molecular Hydrogen as a Novel Antitumor Agent: Possible Mechanisms Underlying Gene Expression.

International journal of molecular sciences

2021 Review / Meta-analysis Unspecified

2021 · Yamamoto — Molecular Hydrogen as a Novel Protective Agent against Pre-Symptomatic Diseases.

International journal of molecular sciences

2021 Review / Meta-analysis Unspecified

2021 · Schönfeld — How the brain fights fatty acids' toxicity.

Neurochemistry international

2021 Review / Meta-analysis Unspecified

2021 · Hirano — Molecular Hydrogen as a Potential Clinically Applicable Radioprotective Agent.

International journal of molecular sciences

2021 Review / Meta-analysis Unspecified

2021 · Hirano — Potential Therapeutic Applications of Hydrogen in Chronic Inflammatory Diseases: Possible Inhibiting Role on Mitochondrial Stress.

International journal of molecular sciences

2021 Review / Meta-analysis Unspecified

2021 · Shi et al. — Hydrogen treatment: a novel option in liver diseases.

Clinical medicine (London, England)

2021 Review / Meta-analysis Unspecified

2021 · Domoki — Hydrogen-induced Neuroprotection in Neonatal Hypoxic-ischemic Encephalopathy.

Current pharmaceutical design

2021 Review / Meta-analysis Unspecified

2021 · Nogueira et al. — Recent Advances in Molecular Hydrogen Research Reducing Exercise-Induced Oxidative Stress and Inflammation.

Current pharmaceutical design

2021 Review / Meta-analysis Unspecified

2021 · Shaik et al. — An Overview of Ovarian Cancer: Molecular Processes Involved and Development of Target-based Chemotherapeutics.

Current topics in medicinal chemistry

2021 Review / Meta-analysis Unspecified

2021 · Li et al. — Recent advances in studies of molecular hydrogen in the treatment of pancreatitis.

Life sciences

2021 Review / Meta-analysis Unspecified

2021 · Chen et al. — Neuroprotective Effects of Molecular Hydrogen: A Critical Review.

Neuroscience bulletin

2021 Review / Meta-analysis Unspecified

2021 · Bajgai et al. — Role of Molecular Hydrogen in Skin Diseases and its Impact in Beauty.

Current pharmaceutical design

2021 Review / Meta-analysis Unspecified

2021 · Ohta — Direct Targets and Subsequent Pathways for Molecular Hydrogen to Exert Multiple Functions: Focusing on Interventions in Radical Reactions

Current pharmaceutical design

2021 Review / Meta-analysis Unspecified

2021 · Lucas — Molecular hydrogen (H₂) as a potential treatment for acute and chronic fatigue

Archiv der Pharmazie

2021 Review / Meta-analysis Unspecified

2021 · Slezak et al. — Oxidative Stress and Pathways of Molecular Hydrogen Effects in Medicine

Current pharmaceutical design

2021 Review / Meta-analysis Unspecified

2021 · Huang et al. — Molecular Hydrogen Application in Stroke: Bench to Bedside

Current pharmaceutical design

2020 Review / Meta-analysis Unspecified

2020 · Hu — Molecular hydrogen: A potential radioprotective agent

Biomedicine & Pharmacotherapy

2020 Review / Meta-analysis Unspecified

2020 · Wang — Prospects of molecular hydrogen in perioperative neuroprotection from basic research to clinical application

Current Opinion in Anaesthesiology

2019 Review / Meta-analysis Unspecified

2019 · Morris — Myalgic encephalomyelitis/chronic fatigue syndrome: From pathophysiological insights to novel therapeutic opportunities.

Pharmacological research

2019 Review / Meta-analysis Unspecified

2019 · Cejka et al. — The preventive and therapeutic effects of molecular hydrogen in ocular diseases and injuries where oxidative stress is involved.

Free radical research

2019 Review / Meta-analysis Unspecified

2019 · Kura et al. — Molecular hydrogen: potential in mitigating oxidative-stress-induced radiation injury.

Canadian journal of physiology and pharmacology

2019 Review / Meta-analysis Unspecified

2019 · Tao et al. — Molecular hydrogen: current knowledge on mechanism in alleviating free radical damage and diseases.

Acta biochimica et biophysica Sinica

2018 Review / Meta-analysis Unspecified

2018 · Ye — Recent Advances in the Electro-Oxidation of Urea for Direct Urea Fuel Cell and Urea Electrolysis.

Topics in current chemistry (Cham)

2018 Review / Meta-analysis Unspecified

2018 · Zhang — Hydrogen Therapy in Cardiovascular and Metabolic Diseases: from Bench to Bedside

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

2018 Review / Meta-analysis Unspecified

2018 · Morris — The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders

Sleep medicine reviews

2016 Review / Meta-analysis Unspecified

2016 · Slezák — Preventive and Therapeutic Application of Molecular Hydrogen in Situations with Excessive Production of Free Radicals

Physiological research

2016 Review / Meta-analysis Unspecified

2016 · Zheng — Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis

Oxidative medicine and cellular longevity

2016 Review / Meta-analysis Unspecified

2016 · Verghese — Complementary therapies for bladder pain syndrome: a systematic review

International urogynecology journal

2015 Review / Meta-analysis Unspecified

2015 · Ohta — Initiation, Development and Potential of Hydrogen Medicine: Toward Therapeutic and Preventive Applications of Molecular Hydrogen Against a Variety of Diseases

Seikagaku. The Journal of Japanese Biochemical Society

2015 Review / Meta-analysis Unspecified

2015 · Dubé — Direct Interspecies Electron Transfer in Anaerobic Digestion: A Review

Advances in biochemical engineering/biotechnology

2015 Review / Meta-analysis Unspecified

2015 · Vogt et al. — Chemical communication in the gut: Effects of microbiota-generated metabolites on gastrointestinal bacterial pathogens.

Anaerobe

2015 Review / Meta-analysis Unspecified

2015 · Ostojic — Molecular hydrogen: An inert gas turns clinically effective.

Annals of medicine

2015 Review / Meta-analysis Unspecified

2015 · Ostojic — Targeting molecular hydrogen to mitochondria: barriers and gateways.

Pharmacological research

2015 Review / Meta-analysis Unspecified

2015 · Ostojic — Molecular hydrogen in sports medicine: new therapeutic perspectives.

International journal of sports medicine

2013 Review / Meta-analysis Unspecified

2013 · Wang — Introspection of oxidant/antioxidant imbalance in the inner ear

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery

2013 Review / Meta-analysis Unspecified

2013 · Schönfeld — Why does brain metabolism not favor burning of fatty acids to provide energy? Reflections on disadvantages of the use of free fatty acids as fuel for brain

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

2013 Review / Meta-analysis Unspecified

2013 · Ishibashi — Molecular hydrogen: new antioxidant and anti-inflammatory therapy for rheumatoid arthritis and related diseases

Current pharmaceutical design

2012 Review / Meta-analysis Unspecified

2012 · Tran et al. — Proton reduction to hydrogen in biological and chemical systems.

Physical chemistry chemical physics : PCCP

2011 Review / Meta-analysis Unspecified

2011 · Noda et al. — The principle and the potential approach to ROS-dependent cytotoxicity by non-pharmaceutical therapies: optimal use of medical gases with antioxidant properties.

Current pharmaceutical design

2011 Review / Meta-analysis Unspecified

2011 · Naeem et al. — Defective protein folding and aggregation as the basis of neurodegenerative diseases: the darker aspect of proteins.

Cell biochemistry and biophysics

2010 Review / Meta-analysis Unspecified

2010 · Hong — Research Advances on Hydrogen Therapy in Nervous System Diseases

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences

2010 Review / Meta-analysis Unspecified

2010 · Otzen — Amyloid formation in surfactants and alcohols: membrane mimetics or structural switchers?

Current protein & peptide science

2006 Review / Meta-analysis Unspecified

2006 · Klemperer — Interstellar chemistry

Proceedings of the National Academy of Sciences of the United States of America

2003 Review / Meta-analysis Unspecified

2003 · Maier — Availability and use of molecular hydrogen as an energy substrate for Helicobacter species

Microbes and infection

2002 Review / Meta-analysis Unspecified

2002 · Nicolet et al. — Fe-only hydrogenases: structure, function and evolution

Journal of inorganic biochemistry

1996 Review / Meta-analysis Unspecified

1996 · Mehta — Magnetization Transfer Magnetic Resonance Imaging: A Clinical Review

Topics in magnetic resonance imaging : TMRI

2025 RCT Human H₂ therapy Unspecified

2025 · Korchazhkina — Effectiveness of Non-Drug Technologies to Increase Stress Resistance in Persons with Extreme Work Profiles and Susceptibility for Professional Burnout

Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury

2025 RCT Human H₂ therapy Unspecified

2025 · Shogenova — Efficiency and Safety of the Combined Use of Thermal Heliox, Nitric Oxide and Molecular Hydrogen in COPD Exacerbation with Respiratory Failure and Pulmonary Hypertension in the Post-COVID Period

Terapevticheskii arkhiv

2026 Pilot / Observational Human H₂ therapy Unspecified

2026 · Liu et al. — Adjuvant Molecular Hydrogen Therapy in SLE-associated Pulmonary Arterial Hypertension: A Case Report on Immunomodulatory Effects on Regulatory and Effector Lymphocytes

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Kotenko et al. — Biochemical Markers of Stress in Medical Workers With Occupational Burnout Syndrome and Their Dynamics Under Physiotherapeutic Factors

Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury

2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Liu et al. — Dynamic Immunomodulation by Hydrogen Capsule Therapy in SLE-associated Pulmonary Arterial Hypertension: A Case Report

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Tsai et al. — Molecular Hydrogen as an Adjuvant Therapy in Comorbid Sjögren's Syndrome, SLE, and ILD: A Case Report on Immune Modulation and Fatigue Reduction

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Lin et al. — Molecular Hydrogen Capsule Therapy for Primary Biliary Cholangitis With Elevated IgG4: A Case Report on Immune Marker Normalization

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Hsu et al. — Molecular Hydrogen Therapy Enhances Immune Markers in Treg, Plasma, Tr1 Cells, and KLRG1 Expression on Tc Cells: A Case of Acute SDH With Midline Shift and Uncal Herniation Post-decompressive Craniectomy

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Tu et al. — Molecular Hydrogen Therapy for SLE-PAH: Case Report on Immune Marker Modulation

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Lin et al. — Molecular Hydrogen as an Adjuvant Therapy in Severe Lupus Serositis With Heart Failure: A Case Report on Immune Modulation and Fatigue Reduction

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Nakayama et al. — Hemodialysis Employing Molecular Hydrogen (H₂) Enriched Dialysis Solution May Improve Dialysis-Related Fatigue Through Impact on Energy Metabolism

Scientific reports

2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Lin et al. — Molecular Hydrogen as a Potential Adjunctive Therapy to Improve Renal Function and Reduce Fatigue in an Elderly Patient With Chronic Comorbidities: A Case Report

In vivo (Athens, Greece)

2024 Pilot / Observational Human H₂ therapy Unspecified

2024 · Lin — Molecular Hydrogen Therapy in Sjögren's Syndrome With Pulmonary Arterial Hypertension and Right-sided Heart Failure: A Case Report of Improved Immune Markers Including Treg, B Cells and Plasma Cell.

In vivo (Athens, Greece)

2024 Pilot / Observational Human H₂ therapy Unspecified

2024 · Xie — A novel intervention of molecular hydrogen on the unbalance of the gut microbiome in opioid addiction: Experimental and human studies.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024 Pilot / Observational Human H₂ therapy Unspecified

2024 · Lui — Molecular Hydrogen as a Promising Therapy Could Be Linked With Increased Resting Treg Cells or Decreased Fas+ T Cell Subsets in a IgG4-PF-ILD Patient: A Case Report.

In vivo (Athens, Greece)

2018 Pilot / Observational Human H₂ therapy Unspecified

2018 · Franceschelli — Modulation of the Oxidative Plasmatic State in Gastroesophageal Reflux Disease with the Addition of Hydrogen-Rich Water: A New Biological Vision

Journal of cellular and molecular medicine

2018 Pilot / Observational Human H₂ therapy Unspecified

2018 · Nakayama — Novel Haemodialysis Treatment Employing Molecular Hydrogen-Enriched Dialysis Solution Improves Prognosis of Chronic Dialysis Patients: A Prospective Observational Study

Scientific reports

2017 Pilot / Observational Human H₂ therapy Unspecified

2017 · Nakayama et al. — Possible clinical effects of molecular hydrogen (H₂) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation.

PloS one

2006 Pilot / Observational Human H₂ therapy Unspecified

2006 · Huang et al. — Electrolyzed-Reduced Water Reduced Hemodialysis-Induced Erythrocyte Impairment in End-Stage Renal Disease Patients

Kidney international

2026 Mechanism / Preclinical Unspecified

2026 · Zhu — Self-Adaptive Hydrogen Nano-Delivery System in Glaucoma Management: Synergistic Antioxidation and Anti-inflammation Therapeutic Strategy

ACS nano

2026 Mechanism / Preclinical Unspecified

2026 · Němec — The Far Side of Carboranes: Anticancer Active Monocations and Ambiently Stable Dications

Angewandte Chemie (International ed. in English)

2026 Mechanism / Preclinical Unspecified

2026 · Bordoni — Ru-Based NSAIDs as Potential Anticancer Therapeutics

Molecules (Basel, Switzerland)

2026 Mechanism / Preclinical Unspecified

2026 · Zhang — Sub-nano Molybdenum Oxide Nanorings as Amplified Atomic Efficiency Sonosensitizers for Highly Efficient Sonodynamic Tumor Ablation

Nanoscale

2026 Mechanism / Preclinical Unspecified

2026 · Jiao — Therapeutic Potential of Magnesium Diboride Nanosheets in PAH-Associated Right Heart Failure: Integrated Multi-Omics Analysis Reveals Ferroptosis Suppression via LC3/ATG5/NCOA4/FTH1 Pathway

Free radical biology & medicine

2026 Mechanism / Preclinical Unspecified

2026 · Lei — Synergistic Stretching-Annealing and Salting-Out Enabling Ultrastrong, Ultratough Anisotropic Bacterial Cellulose Conductive Hydrogels for Bioelectric Sensors

Carbohydrate polymers

2025 Mechanism / Preclinical Unspecified

2025 · Negishi — The Rieske Iron-sulfur Protein Is a Primary Target of Molecular Hydrogen

Redox biology

2025 Mechanism / Preclinical Unspecified

2025 · Chu — Hydrogen Enhanced Photothermal Therapy for Redox-regulated Tumor Apoptosis and Immune Reprogramming

Acta biomaterialia

2025 Mechanism / Preclinical Unspecified

2025 · Liu — Local Delivery of Molecular Hydrogen by Fluorinated Zeolitic Imidazole Framework Nanosheets Boosts Cancer Immunotherapy.

ACS applied materials & interfaces

2025 Mechanism / Preclinical Unspecified

2025 · Valizadeh — Integrating QSAR modeling, ADMET screening, molecular docking, and molecular dynamics simulations to identify potential MCF-7 inhibitors.

Computers in biology and medicine

2025 Mechanism / Preclinical Unspecified

2025 · Li — Hydrogen promoted mitochondrial autophagy and alleviated CIH-induced vascular endothelial cell senescence by regulating oxidative stress.

European journal of pharmacology

2025 Mechanism / Preclinical Unspecified

2025 · Huang — Magnesium hydride-induced hydrogen therapy for enhanced sonodynamic therapy.

Materials horizons

2025 Mechanism / Preclinical Unspecified

2025 · Zhang — Ternary Schottky Junction for Sonocatalytic Water Splitting in Gas-Immunotherapy-Mediated Cancer Treatment.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2025 Mechanism / Preclinical Unspecified

2025 · Chen — A Sustained H₂/Fluorouracil-Releasing Suppository for High-efficacy and Low-Toxicity Hydrogenochemotherapy of Colon Cancer.

Advanced healthcare materials

2025 Mechanism / Preclinical Unspecified

2025 · Yu — Protective Effects of Hydrogen Treatment Against High Glucose-Induced Oxidative Stress and Apoptosis via Inhibition of the AGEs/RAGE/NF-κB Signaling Pathway in Skin Cells.

Endocrine, metabolic & immune disorders drug targets

2025 Mechanism / Preclinical Unspecified

2025 · Su — Multifaceted Immunomodulatory Nanocomplexes Target Neutrophilic-ROS Inflammation in Acute Lung Injury.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2025 Mechanism / Preclinical Unspecified

2025 · Jiang — Engineering probiotic biohydrogen micro-factories to initiate reductive stress for boosting tumor vulnerability.

Biomaterials

2024 Mechanism / Preclinical Unspecified

2024 · Li — Modulating the Electronic Structure of MnNi₂S₃ Nanoelectrodes to Activate Pyroptosis for Electrocatalytic Hydrogen-Immunotherapy.

Advanced materials (Deerfield Beach, Fla.)

2024 Mechanism / Preclinical Unspecified

2024 · Haribabu — Multifaceted exploration of acylthiourea compounds: In vitro cytotoxicity, DFT calculations, molecular docking and dynamics simulation studies.

International journal of biological macromolecules

2024 Mechanism / Preclinical Unspecified

2024 · Benoit — d-aspartate, an amino-acid important for human health, supports anaerobic respiration in several Campylobacter species.

Research in microbiology

2024 Mechanism / Preclinical Unspecified

2024 · Xu — Poly(ionic liquid)-Flocculated Chlorella Loading Bactericidal and Antioxidant Hydrogel as a Biological Hydrogen Therapy for Diabetic Wound Dressing.

ACS applied materials & interfaces

2024 Mechanism / Preclinical Unspecified

2024 · Lin — Hydrogen-treated CoCrMo alloy: a novel approach to enhance biocompatibility and mitigate inflammation in orthopedic implants.

Journal of materials chemistry. B

2024 Mechanism / Preclinical Unspecified

2024 · Meng — Hydrogen Therapy Reverses Cancer-Associated Fibroblasts Phenotypes and Remodels Stromal Microenvironment to Stimulate Systematic Anti-Tumor Immunity.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2024 Mechanism / Preclinical Unspecified

2024 · Yano et al. — Charge Neutralization and β-Elimination Cleavage Mechanism of Family 42 L-Rhamnose-α-1,4-D-Glucuronate Lyase Revealed Using Neutron Crystallography

The Journal of biological chemistry

2023 Mechanism / Preclinical Unspecified

2023 · Agar — The Inhibition Mechanism of Pancreatic Ductal Adenocarcinoma via LXR Receptors: A Multifaceted Approach Integrating Molecular Docking, Molecular Dynamics and Post-MD Inter-Molecular Contact Analysis

Asian Pacific journal of cancer prevention : APJCP

2023 Mechanism / Preclinical Unspecified

2023 · Wang — pH-Responsive Delivery of H₂ through Ammonia Borane-Loaded Hollow Polydopamine for Intervertebral Disc Degeneration Therapy

Oxidative medicine and cellular longevity

2023 Mechanism / Preclinical Unspecified

2023 · Antonenko — Biological Activity of Novel Organotin Compounds with a Schiff Base Containing an Antioxidant Fragment

International journal of molecular sciences

2023 Mechanism / Preclinical Unspecified

2023 · Zhu — Two-Dimensional Mg₂Si Nanosheet-Enabled Sustained Hydrogen Generation for Improved Repair and Regeneration of Deeply Burned Skin

Advanced healthcare materials

2023 Mechanism / Preclinical Unspecified

2023 · Yang — Molecular Hydrogen Promotes Adipose-derived Stem Cell Myogenic Differentiation via Regulation of Mitochondria

Current stem cell research & therapy

2022 Mechanism / Preclinical Unspecified

2022 · Xiao et al. — Red Tide Short-Time Prediction Using GRU Network Model Based on Multi-Feature Factors: A Case Study in Xiamen Sea Area

Marine environmental research

2022 Mechanism / Preclinical Unspecified

2022 · Di et al. — A Bio-Inspired, Ultra-Tough, High-Sensitivity, and Anti-Swelling Conductive Hydrogel Strain Sensor for Motion Detection and Information Transmission

Materials horizons

2022 Mechanism / Preclinical Unspecified

2022 · Sebastiampillai et al. — Using a High-Throughput, Whole-Cell Hydrogenase Assay to Identify Potential Small Molecule Inhibitors of [NiFe]-Hydrogenase

Metallomics : integrated biometal science

2022 Mechanism / Preclinical Unspecified

2022 · González et al. — Dehydrochlorination of PCDDs on SWCN-Supported Ni₁₀ and Ni₁₃ Clusters: A DFT Study

Molecules (Basel, Switzerland)

2022 Mechanism / Preclinical Unspecified

2022 · Yan et al. — Microbial Hydrogen „Manufactory” for Enhanced Gas Therapy and Self-Activated Immunotherapy via Reduced Immune Escape

Journal of nanobiotechnology

2022 Mechanism / Preclinical Unspecified

2022 · Geng et al. — Hydrogen Helps to Ameliorate Staphylococcus aureus-Induced Mastitis in Mice

International immunopharmacology

2022 Mechanism / Preclinical Unspecified

2022 · Yang — Magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer growth

Nature communications

2022 Mechanism / Preclinical Unspecified

2022 · Zhang — Metal-Organic-Framework-Based Hydrogen-Release Platform for Multieffective Helicobacter Pylori Targeting Therapy and Intestinal Flora Protective Capabilities

Advanced materials (Deerfield Beach, Fla.)

2022 Mechanism / Preclinical Unspecified

2022 · Wang — Regulation of chlorothalonil degradation by molecular hydrogen

Journal of hazardous materials

2022 Mechanism / Preclinical Unspecified

2022 · Saitoh — Molecular hydrogen suppresses Porphyromonas gingivalis lipopolysaccharide-induced increases in interleukin-1 alpha and interleukin-6 secretion in human gingival cells.

Molecular and cellular biochemistry

2021 Mechanism / Preclinical Unspecified

2021 · Marzullo et al. — Ammonium Formate-Pd/C as a New Reducing System for 1,2,4-Oxadiazoles: Synthesis of Guanidine Derivatives and Reductive Rearrangement to Quinazolin-4-Ones with Potential Anti-Diabetic Activity

International journal of molecular sciences

2021 Mechanism / Preclinical Unspecified

2021 · Patterson et al. — H₂ in Antarctic Firn Air: Atmospheric Reconstructions and Implications for Anthropogenic Emissions

Proceedings of the National Academy of Sciences of the United States of America

2021 Mechanism / Preclinical Unspecified

2021 · Bai et al. — A PdMo Bimetallene with Precise Wavelength Adjustment and Catalysis for Synergistic Photothermal Ablation and Hydrogen Therapy of Cancer at Different Depths

Journal of materials chemistry. B

2021 Mechanism / Preclinical Unspecified

2021 · Hughes — Reshaping of bacterial molecular hydrogen metabolism contributes to the outgrowth of commensal E. coli during gut inflammation

eLife

2021 Mechanism / Preclinical Unspecified

2021 · V — Investigations of Dianhydro-D-glucitol adsorbed on AuNPs surface: In silico and in vitro approach based on anticancer activity studies against A549 lung cancer cell lines

Journal of molecular recognition : JMR

2021 Mechanism / Preclinical Unspecified

2021 · Wang et al. — Hydrogen therapy as an effective and novel adjuvant treatment against COVID-19

QJM : monthly journal of the Association of Physicians

2021 Mechanism / Preclinical Unspecified

2021 · Wang et al. — Response to: Hydrogen therapy as an effective and novel adjuvant treatment against COVID-19

QJM : monthly journal of the Association of Physicians

2020 Mechanism / Preclinical Unspecified

2020 · Ichikawa et al. — Proposal of next-generation medical care „Mega-hydrogen Therapy”

Medical gas research

2020 Mechanism / Preclinical Unspecified

2020 · Murugesan et al. — Catalytic reductive aminations using molecular hydrogen for synthesis of different kinds of amines

Chemical Society reviews

2020 Mechanism / Preclinical Unspecified

2020 · Kato — Hydrogen-bubbled Platinum-colloid Suppresses Human Esophagus- or Tongue-carcinoma Cells with Intracellular Platinum-uptake and the Diminished Normal-cell Mortality

Human cell

2020 Mechanism / Preclinical Unspecified

2020 · Holweg — A Lean Magnesium-Zinc-Calcium Alloy ZX00 Used for Bone Fracture Stabilization in a Large Growing-Animal Model

Acta biomaterialia

2020 Mechanism / Preclinical Unspecified

2020 · Wang — NIR-Driven Water Splitting H₂ Production Nanoplatform for H₂-Mediated Cascade-Amplifying Synergetic Cancer Therapy

ACS applied materials & interfaces

2020 Mechanism / Preclinical Unspecified

2020 · Bhattacharya — Effect of aggrecan degradation on the nanomechanics of hyaluronan in extra-fibrillar matrix of annulus fibrosus: A molecular dynamics investigation.

Journal of the mechanical behavior of biomedical materials

2020 Mechanism / Preclinical Unspecified

2020 · Liu — Effect of thermal treatments on in vitro starch digestibility of sorghum dried noodles.

Food & function

2020 Mechanism / Preclinical Unspecified

2020 · Wang — Hydrogen exerts neuroprotection by activation of the miR-21/PI3K/AKT/GSK-3β pathway in an in vitro model of traumatic brain injury.

Journal of cellular and molecular medicine

2020 Mechanism / Preclinical Unspecified

2020 · Ishihara — Molecular hydrogen suppresses superoxide generation in the mitochondrial complex I and reduced mitochondrial membrane potential.

Biochemical and biophysical research communications

2020 Mechanism / Preclinical Unspecified

2020 · Niu — Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch

Scientific Reports

2019 Mechanism / Preclinical Unspecified

2019 · Herdendorf — Staphylococcus aureus Evasion Proteins EapH1 and EapH2: Residue-Level Investigation of an Alternative Binding Motif for Human Neutrophil Elastase

Archives of biochemistry and biophysics

2019 Mechanism / Preclinical Unspecified

2019 · Schmidt — Lifetime of Parahydrogen in Aqueous Solutions and Human Blood

Chemphyschem : a European journal of chemical physics and physical chemistry

2019 Mechanism / Preclinical Unspecified

2019 · Amberg — Effect of Physical Cues of Altered Extract Media from Biodegradable Magnesium Implants on Human Gingival Fibroblasts

Acta biomaterialia

2019 Mechanism / Preclinical Unspecified

2019 · Iuchi — Molecular Hydrogen Suppresses Free-Radical-Induced Cell Death by Mitigating Fatty Acid Peroxidation and Mitochondrial Dysfunction

Canadian journal of physiology and pharmacology

2019 Mechanism / Preclinical Unspecified

2019 · Kröninger — Energy Conservation in the Gut Microbe Methanomassiliicoccus luminyensis Is Based on Membrane-Bound Ferredoxin Oxidation Coupled to Heterodisulfide Reduction

The FEBS journal

2019 Mechanism / Preclinical Unspecified

2019 · Moon — Different Molecular Interaction between Collagen and α- or β-Chitin in Mechanically Improved Electrospun Composite

Marine drugs

2019 Mechanism / Preclinical Unspecified

2019 · Htun — Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model.

Scientific reports

2018 Mechanism / Preclinical Unspecified

2018 · Nobela — Efficient discrimination of natural stereoisomers of chicoric acid, an HIV-1 integrase inhibitor

Journal of photochemistry and photobiology. B, Biology

2018 Mechanism / Preclinical Unspecified

2018 · Begum — Molecular hydrogen may enhance the production of testosterone hormone in male infertility through hormone signal modulation and redox balance

Medical hypotheses

2018 Mechanism / Preclinical Unspecified

2018 · Tamaki — Hydrogen Flush After Cold Storage as a New End-Ischemic Ex Vivo Treatment for Liver Grafts Against Ischemia/Reperfusion Injury

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

2018 Mechanism / Preclinical Unspecified