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Inhalation

Inhalation of hydrogen gas: breathing a low-concentration H₂ (often H₂/O₂) mixture, typically through a nasal cannula. Concentration and duration vary considerably from study to study.

Human studies on molecular hydrogen given by Inhalation. This page collects the 248 studies using this route — 14 randomized trials, 31 pilot/observational studies and 62 reviews. Listed newest first.

2026 Review / Meta-analysis Inhalation

2026 · Seneff — The essential role of hydrogen gas recycling by gut microbes in reducing deuterium load in host mitochondria: is trimethylamine oxide a deuterium sensor?

Metabolomics : Official journal of the Metabolomic Society

2026 Review / Meta-analysis Inhalation

2026 · Nguyen Puente — Emerging Clinical Applications for Molecular Hydrogen

Respiratory care

2026 Review / Meta-analysis Inhalation

2026 · Merigo — Gas Therapies for Neuro-Protection

Critical care clinics

2026 Review / Meta-analysis Inhalation Saline / IV Drinking (HRW)

2026 · Nguyen — Advances in hydrogen delivery strategies for therapeutic applications

Advanced drug delivery reviews

2026 Review / Meta-analysis Inhalation

2026 · Pan — Stimuli-Responsive Hydrogen Production from Nanomaterials: Design, Regulation and Biomedical Applications

Advanced healthcare materials

2025 Review / Meta-analysis Inhalation

2025 · Zamanian — The Roles of Neuroinflammation in l-DOPA-Induced Dyskinesia: Dissecting the Roles of NF-κB and TNF-α for Novel Pharmacological Therapeutic Approaches

The European journal of neuroscience

2025 Review / Meta-analysis Inhalation

2025 · Li — Application Trends of Hydrogen-generating Nanomaterials for the Treatment of ROS-related Diseases

Biomaterials science

2024 Review / Meta-analysis Inhalation

2024 · Xu — The Landscape of Smart Biomaterial-Based Hydrogen Therapy

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2024 Review / Meta-analysis Inhalation

2024 · Tsuzuki — Idiopathic Sudden Sensorineural Hearing Loss: A Review Focused on the Contribution of Vascular Pathologies

Auris, nasus, larynx

2024 Review / Meta-analysis Inhalation

2024 · Afkhami — Exploring Approaches to Pulp Vitality Assessment: A Scoping Review of Nontraditional Methods

International endodontic journal

2024 Review / Meta-analysis Inhalation

2024 · Khan — Catalytic innovations: Improving wastewater treatment and hydrogen generation technologies.

Journal of environmental management

2024 Review / Meta-analysis Inhalation

2024 · James et al. — The Synergistic Potential of Hydrogen Inhalation and Hyperbaric Oxygen Therapy

Journal of vascular surgery

2024 Review / Meta-analysis Inhalation

2024 · Takefuji — Hydrogen Inhalation Therapy for Inflammation and Eye Diseases: A Review of the Literature

Eye (London, England)

2023 Review / Meta-analysis Inhalation Saline / IV Drinking (HRW)

2023 · Kuo — Molecular Hydrogen: Emerging Treatment for Stroke Management

Chemical Research in Toxicology

2023 Review / Meta-analysis Inhalation

2023 · Johnsen et al. — Molecular Hydrogen Therapy — A Review on Clinical Studies and Outcomes

Molecules (Basel, Switzerland)

2023 Review / Meta-analysis Inhalation Saline / IV Bath / Topical Drinking (HRW)

2023 · Saengsin et al. — Hydrogen Therapy as a Potential Therapeutic Intervention in Heart Disease: From the Past Evidence to Future Application

Cellular and molecular life sciences : CMLS

2023 Review / Meta-analysis Inhalation Drinking (HRW)

2023 · Li — Trend of research on the medical use of molecular hydrogen: a bibliometric analysis

Medical gas research

2022 Review / Meta-analysis Inhalation

2022 · Biswas — Electrocoagulation and electrooxidation technologies for pesticide removal from water or wastewater: A review

Chemosphere

2021 Review / Meta-analysis Inhalation Drinking (HRW)

2021 · Noda — Neuroprotective and Preventative Effects of Molecular Hydrogen

Current Pharmaceutical Design

2021 Review / Meta-analysis Inhalation Drinking (HRW)

2021 · Bragina — Intestinal microbiota of athletes.

Voprosy pitaniia

2021 Review / Meta-analysis Inhalation Saline / IV Bath / Topical Drinking (HRW)

2021 · Quan — Protective effects of molecular hydrogen on lung injury from lung transplantation.

Experimental biology and medicine (Maywood, N.J.)

2021 Review / Meta-analysis Inhalation

2021 · Magliocca et al. — Inhaled gases as novel neuroprotective therapies in the postcardiac arrest period.

Current opinion in critical care

2021 Review / Meta-analysis Inhalation

2021 · Chen et al. — Chemical and Biochemical Aspects of Molecular Hydrogen in Treating Kawasaki Disease and COVID-19.

Chemical research in toxicology

2021 Review / Meta-analysis Inhalation Bath / Topical

2021 · Zhang et al. — Hydrogen Gas: A Novel Type of Antioxidant in Modulating Sexual Organs Homeostasis.

Oxidative medicine and cellular longevity

2021 Review / Meta-analysis Inhalation Saline / IV

2021 · Sano et al. — Hydrogen Gas Therapy: From Preclinical Studies to Clinical Trials.

Current pharmaceutical design

2021 Review / Meta-analysis Inhalation

2021 · Li et al. — Hydrogen Commonly Applicable from Medicine to Agriculture: From Molecular Mechanisms to the Field.

Current pharmaceutical design

2021 Review / Meta-analysis Inhalation

2021 · Htun et al. — Hydrogen and Therapeutic Gases for Neonatal Hypoxic-Ischemic Encephalopathy: Potential Neuroprotective Adjuncts in Translational Research

Pediatric research

2021 Review / Meta-analysis Inhalation

2021 · Ostojic — Hydrogen as a Potential Therapeutic in Obesity: Targeting the Brain

Trends in endocrinology and metabolism: TEM

2021 Review / Meta-analysis Inhalation Saline / IV Drinking (HRW)

2021 · Ostojic — Hydrogen Gas as an Exotic Performance-Enhancing Agent: Challenges and Opportunities

Current pharmaceutical design

2020 Review / Meta-analysis Inhalation

2020 · Hirano et al. — A „philosophical molecule,” hydrogen may overcome senescence and intractable diseases

Medical gas research

2020 Review / Meta-analysis Inhalation

2020 · Chen et al. — The future of cryoablation: An abscopal effect

Cryobiology

2020 Review / Meta-analysis Inhalation Bath / Topical Drinking (HRW)

2020 · Kawamura et al. — Application of Molecular Hydrogen as a Novel Antioxidant in Sports Science

Oxidative medicine and cellular longevity

2019 Review / Meta-analysis Inhalation

2019 · Zhou — Micro/Nanomaterials-Augmented Hydrogen Therapy

Advanced Healthcare Materials

2019 Review / Meta-analysis Inhalation

2019 · Qian — Medical Application of Hydrogen in Hematological Diseases.

Oxidative medicine and cellular longevity

2019 Review / Meta-analysis Inhalation Saline / IV Drinking (HRW)

2019 · LeBaron et al. — A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress.

Molecules (Basel, Switzerland)

2019 Review / Meta-analysis Inhalation Drinking (HRW)

2019 · LeBaron et al. — Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes.

Canadian journal of physiology and pharmacology

2019 Review / Meta-analysis Inhalation

2019 · Li et al. — Hydrogen as a complementary therapy against ischemic stroke: A review of the evidence.

Journal of the neurological sciences

2019 Review / Meta-analysis Inhalation

2019 · Wu — Hydrogen Gas from Inflammation Treatment to Cancer Therapy

ACS nano

2018 Review / Meta-analysis Inhalation

2018 · Hylemon — Metabolism of hydrogen gases and bile acids in the gut microbiome

FEBS letters

2017 Review / Meta-analysis Inhalation Saline / IV Drinking (HRW)

2017 · Iketani — Molecular Hydrogen as a Neuroprotective Agent

Current Neuropharmacology

2015 Review / Meta-analysis Inhalation Saline / IV Bath / Topical Drinking (HRW)

2015 · Ohta — Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications.

Methods in enzymology

2015 Review / Meta-analysis Inhalation

2015 · Shimura et al. — Radiation occupational health interventions offered to radiation workers in response to the complex catastrophic disaster at the Fukushima Daiichi Nuclear Power Plant.

Journal of radiation research

2015 Review / Meta-analysis Inhalation

2015 · Torzillo et al. — Advances in the biotechnology of hydrogen production with the microalga Chlamydomonas reinhardtii.

Critical reviews in biotechnology

2015 Review / Meta-analysis Inhalation Drinking (HRW)

2015 · Osonoi — [Alpha-glucosidase inhibitor]. (Nihon Rinsho)

Nihon rinsho. Japanese journal of clinical medicine

2014 Review / Meta-analysis Inhalation

2014 · Xie et al. — Hydrogen gas presents a promising therapeutic strategy for sepsis.

BioMed research international

2014 Review / Meta-analysis Inhalation Saline / IV Bath / Topical Drinking (HRW)

2014 · Ohta — Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine.

Pharmacology & therapeutics

2013 Review / Meta-analysis Inhalation

2013 · Zheng — Equol: a metabolite of soy isoflavones by intestinal microflora — a review

Wei sheng wu xue bao = Acta microbiologica Sinica

2013 Review / Meta-analysis Inhalation

2013 · Lucas — Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway

Molecular neurobiology

2012 Review / Meta-analysis Inhalation

2012 · Carbonero et al. — Contributions of the microbial hydrogen economy to colonic homeostasis.

Nature reviews. Gastroenterology & hepatology

2012 Review / Meta-analysis Inhalation Saline / IV Bath / Topical Drinking (HRW)

2012 · Ohta — Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases.

Biochimica et biophysica acta

2012 Review / Meta-analysis Inhalation

2012 · Nie et al. — Hydrogenase: the next antibiotic target?

Clinical science (London, England : 1979)

2011 Review / Meta-analysis Inhalation Saline / IV Bath / Topical Drinking (HRW)

2011 · Ohta — Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications.

Current pharmaceutical design

2011 Review / Meta-analysis Inhalation

2011 · Zheng et al. — Hydrogen resuscitation, a new cytoprotective approach.

Clinical and experimental pharmacology & physiology

2010 Review / Meta-analysis Inhalation

2010 · Shen — Hydrogen as a novel and effective treatment of acute carbon monoxide poisoning.

Medical hypotheses

2009 Review / Meta-analysis Inhalation Drinking (HRW)

2009 · Mahlen — Oral abscess caused by Campylobacter rectus: case report and literature review.

Journal of clinical microbiology

2004 Review / Meta-analysis Inhalation Drinking (HRW)

2004 · Züttel — Hydrogen storage methods

Die Naturwissenschaften

1999 Review / Meta-analysis Inhalation

1999 · Särnblad — Lactose intolerance in children. An analysis of hydrogen gas in exhaled air simplifies and improves diagnosis.

Lakartidningen

1998 Review / Meta-analysis Inhalation

1998 · Swart — ¹³C breath test in gastroenterological practice.

Scandinavian journal of gastroenterology. Supplement

1994 Review / Meta-analysis Inhalation

1994 · Beglinger — Breath Tests: A Clarification of the Topic

Bildgebung = Imaging

1988 Review / Meta-analysis Inhalation Drinking (HRW)

1988 · Scrimshaw — The acceptability of milk and milk products in populations with a high prevalence of lactose intolerance.

The American journal of clinical nutrition

1988 Review / Meta-analysis Inhalation Drinking (HRW)

1988 · Holm — Role of blood flow in gastric acid secretion.

The American journal of physiology

1983 Review / Meta-analysis Inhalation

1983 · Ostrander — Breath hydrogen analysis: a review of the methodologies and clinical applications.

Journal of pediatric gastroenterology and nutrition

2026 RCT Human H₂ therapy Inhalation

2026 · Grepl — Sixty-minute inhalation of molecular hydrogen decreases blood oxygen saturation but does not alter autonomic cardiac regulation at rest in healthy females: a randomized, double-blind, placebo-controlled crossover study

Canadian Journal of Physiology and Pharmacology

2025 RCT Human H₂ therapy Inhalation Bath / Topical

2025 · Grepl — Molecular hydrogen inhalation modulates resting metabolism in healthy females: findings from a randomized, double-blind, placebo-controlled crossover study

Medical Gas Research

2024 RCT Human H₂ therapy Inhalation

2024 · Chair — The impact of hydrogen inhalation therapy on blood reactive oxygen species levels: A randomized controlled study

Free Radical Biology & Medicine

2024 RCT Human H₂ therapy Inhalation Drinking (HRW)

2024 · Zhao — Hydrogen gas inhalation prior to high-intensity training reduces attenuation of nitric oxide bioavailability in male rugby players

PeerJ

2024 RCT Human H₂ therapy Inhalation

2024 · Dong — Inhalation of Hydrogen-Rich Gas before Acute Exercise Alleviates Exercise Fatigue: A Randomized Crossover Study

International journal of sports medicine

2023 RCT Human H₂ therapy Inhalation

2023 · Deryugina — Molecular hydrogen exposure improves functional state of red blood cells in the early postoperative period: a randomized clinical study

Medical Gas Research

2023 RCT Human H₂ therapy Inhalation

2023 · Lin — Hydrogen Gas Treatment Improves Postoperative Delirium and Cognitive Dysfunction in Elderly Noncardiac Patients

Journal of Personalized Medicine

2022 RCT Human H₂ therapy Inhalation

2022 · Botek — Molecular Hydrogen Positively Affects Physical and Respiratory Function in Acute Post-COVID-19 Patients: A New Perspective in Rehabilitation

International Journal of Environmental Research and Public Health

2022 RCT Human H₂ therapy Inhalation

2022 · Tao — A randomized, placebo-controlled clinical trial of hydrogen/oxygen inhalation for non-alcoholic fatty liver disease

Journal of Cellular and Molecular Medicine

2021 RCT Human H₂ therapy Inhalation

2021 · Yoritaka — Randomized double-blind placebo-controlled trial of hydrogen inhalation for Parkinson's disease: a pilot study

Neurological Sciences

2020 RCT Human H₂ therapy Inhalation Bath / Topical

2020 · Shibayama — Impact of hydrogen-rich gas mixture inhalation through nasal cannula during post-exercise recovery period on subsequent oxidative stress, muscle damage, and exercise performances in men

Medical Gas Research

2017 RCT Human H₂ therapy Inhalation

2017 · Tamura — Efficacy of Inhaled Hydrogen on Neurological Outcome Following Brain Ischemia During Post-Cardiac Arrest Care (HYBRID II Trial): Study Protocol for a Randomized Controlled Trial

Trials

2017 RCT Human H₂ therapy Inhalation Saline / IV

2017 · Ono et al. — Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

2016 RCT Human H₂ therapy Inhalation

2016 · Gong et al. — Protective effect of hydrogen on the lung of sanitation workers exposed to haze.

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases

2026 Pilot / Observational Human H₂ therapy Inhalation Bath / Topical

2026 · Pozdnyakova — The combined use of inhaled nitric oxide and molecular hydrogen in patients with post-COVID-19 syndrome

Terapevticheskii arkhiv

2026 Pilot / Observational Human H₂ therapy Inhalation Bath / Topical

2025 · Moriya et al. — Hydrogen Inhalation Is Associated With a Transient Rightward Shift in Prefrontal Oxyhemoglobin Asymmetry and Autonomic Modulation

Scientific reports

2025 Pilot / Observational Human H₂ therapy Inhalation

2025 · Habet et al. — Hydrogen-FAST: Study Protocol for Inhaled Hydrogen Gas as Adjunctive Therapy in Refractory Cardiac Arrest (ECPR)

Trials

2024 Pilot / Observational Human H₂ therapy Inhalation

2024 · Dong — Hydrogen-Rich Gas Enhanced Sprint-Interval Performance: Metabolomic Insights into Underlying Mechanisms

Nutrients

2024 Pilot / Observational Human H₂ therapy Inhalation

2024 · Pozdnyakova — Rehabilitation program of post-COVID-19 syndrome with the use of nitric oxide and molecular hydrogen

Terapevticheskii Arkhiv

2024 Pilot / Observational Human H₂ therapy Inhalation Bath / Topical

2024 · Salomez-Ihl — H2 inhalation therapy in patients with moderate COVID-19 (H2COVID): a prospective ascending-dose phase I clinical trial

Antimicrobial Agents and Chemotherapy

2024 Pilot / Observational Human H₂ therapy Inhalation

2024 · Tamura — Combination of Hydrogen Inhalation and Hypothermic Temperature Control After Out-of-Hospital Cardiac Arrest: A Post hoc Analysis of the Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During PostCardiac Arrest Care II Trial

Critical Care Medicine

2024 Pilot / Observational Human H₂ therapy Inhalation Saline / IV

2024 · Mu — Hydrogen regulated pyroptosis through NLRP3-GSDMD pathway to improve airway mucosal oxidative stress injury induced by endotracheal tube cuff compression.

Free radical biology & medicine

2024 Pilot / Observational Human H₂ therapy Inhalation

2024 · Ichikawa — Realizing brain therapy with „smart medicine“: mechanism and case report of molecular hydrogen inhalation for Parkinson's disease.

Medical gas research

2024 Pilot / Observational Human H₂ therapy Inhalation Drinking (HRW)

2024 · Lin — Early Hydrogen-Oxygen Gas Mixture Inhalation in Patients with Aneurysmal Subarachnoid Hemorrhage (HOMA): study protocol for a randomized controlled trial.

Trials

2024 Pilot / Observational Human H₂ therapy Inhalation

2024 · Liu — The Benefit of Hydrogen Gas as an Adjunctive Therapy for Chronic Obstructive Pulmonary Disease.

Medicina (Kaunas, Lithuania)

2024 Pilot / Observational Human H₂ therapy Inhalation

2024 · Hirano — Successful treatment of myalgic encephalomyelitis/chronic fatigue syndrome using hydrogen gas: four case reports.

Medical gas research

2023 Pilot / Observational Human H₂ therapy Inhalation Drinking (HRW)

2023 · Wang — Effects of molecular hydrogen intervention on the gut microbiome in methamphetamine abusers with mental disorder.

Brain research bulletin

2022 Pilot / Observational Human H₂ therapy Inhalation

2022 · Zhao — Effectiveness and safety of hydrogen inhalation as an adjunct treatment in Chinese type 2 diabetes patients: A retrospective, observational, double-arm, real-life clinical study

Frontiers in Endocrinology

2022 Pilot / Observational Human H₂ therapy Inhalation

2022 · Deryugina — Dynamics of Metabolic and Oxidative Parameters of Erythrocytes during Treatment of Chronic Heart Failure with Molecular Hydrogen.

Bulletin of experimental biology and medicine

2021 Pilot / Observational Human H₂ therapy Inhalation

2021 · Hirano — Protective effects of hydrogen gas inhalation on radiation-induced bone marrow damage in cancer patients: a retrospective observational study

Medical Gas Research

2021 Pilot / Observational Human H₂ therapy Inhalation

2021 · Kaibori — Effect of hydrogen gas inhalation on patient QOL after hepatectomy: protocol for a randomised controlled trial

Trials

2021 Pilot / Observational Human H₂ therapy Inhalation

2021 · Danilova — Application of Molecular Hydrogen in Heart Surgery under Cardiopulmonary Bypass

Sovremennye tekhnologii v meditsine

2021 Pilot / Observational Human H₂ therapy Inhalation

2021 · Chen — High-flow hydrogen inhalation might suppress the immune function of middle-aged participants: a self-controlled study

Medical gas research

2020 Pilot / Observational Human H₂ therapy Inhalation

2020 · Chen — Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system senescence in patients with advanced non-small cell lung cancer: a self-controlled study

Medical Gas Research

2020 Pilot / Observational Human H₂ therapy Inhalation

2020 · Hori et al. — Inhalation of molecular hydrogen increases breath acetone excretion during submaximal exercise: a randomized, single-blinded, placebo-controlled study.

Medical gas research

2020 Pilot / Observational Human H₂ therapy Inhalation

2020 · Chen et al. — Hydrogen therapy can be used to control tumor progression and alleviate the adverse events of medications in patients with advanced non-small cell lung cancer.

Medical gas research

2020 Pilot / Observational Human H₂ therapy Inhalation

2020 · Wang et al. — Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients.

QJM : monthly journal of the Association of Physicians

2019 Pilot / Observational Human H₂ therapy Inhalation

2019 · Akagi et al. — Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve prognosis.

Oncology reports

2019 Pilot / Observational Human H₂ therapy Inhalation

2019 · Chen et al. — „Real world survey“ of hydrogen-controlled cancer: a follow-up report of 82 advanced cancer patients.

Medical gas research

2018 Pilot / Observational Human H₂ therapy Inhalation

2018 · Akagi — Immunological Effect of Hydrogen Gas: Hydrogen Gas Improves Clinical Outcomes of Cancer Patients

Gan to kagaku ryoho. Cancer & chemotherapy

2017 Pilot / Observational Human H₂ therapy Inhalation

2017 · Katsumata et al. — The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction — First Pilot Study in Humans.

Circulation journal : official journal of the Japanese Circulation Society

2016 Pilot / Observational Human H₂ therapy Inhalation

2016 · Tamura et al. — Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome — First-in-Human Pilot Study.

Circulation journal : official journal of the Japanese Circulation Society

2015 Pilot / Observational Human H₂ therapy Inhalation Saline / IV Drinking (HRW)

2015 · Ishibashi et al. — Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases.

Molecular medicine reports

2013 Pilot / Observational Human H₂ therapy Inhalation Drinking (HRW)

2013 · Shimouchi et al. — Molecular hydrogen consumption in the human body during the inhalation of hydrogen gas.

Advances in experimental medicine and biology

2010 Pilot / Observational Human H₂ therapy Inhalation

2010 · Nakayama et al. — A Novel Bioactive Haemodialysis System Using Dissolved Dihydrogen (H₂) Produced by Water Electrolysis: A Clinical Trial

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2026 Mechanism / Preclinical Inhalation

2026 · Wang — Hydrogen gas inhalation alleviated cerebral ischemia/reperfusion injury by regulating mitophagy in SH-SY5Y cells and mice via PTEN-induced kinase 1/Parkin pathway.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

2026 Mechanism / Preclinical Inhalation

2026 · Sato — Optimization of lens size and ion source parameters for gas chromatography/mass spectrometry-based metabolomics using hydrogen as a carrier gas

Journal of chromatography. A

2026 Mechanism / Preclinical Inhalation

2026 · Zhao — Molecular hydrogen triggers TRPC4-TRPC4AP-dependent reversible calcium transients via extracellular influx

Theranostics

2026 Mechanism / Preclinical Inhalation

2026 · Kiyoi — Transcriptome-Based Evaluation of Hydrogen Gas Effects for Preventing UVA-Induced Photoaging Using an Artificial Skin Model

Geriatrics & gerontology international

2026 Mechanism / Preclinical Inhalation

2026 · Li — MXene-Engineered MgB₂ Nanoprodrugs with Acid-Responsive Hydrogen Evolution for Cooperative Photothermal Cancer Ablation

ACS applied materials & interfaces

2026 Mechanism / Preclinical Inhalation Drinking (HRW)

2026 · Cao — A Hydrogen Generator Enhances Immunogenic Transarterial Chemoembolization in Hepatocellular Carcinoma

Journal of controlled release : official journal of the Controlled Release Society

2026 Mechanism / Preclinical Inhalation

2026 · Liang — Synergistic Calcium Overload and Hydrogen Release Potentiate Robust Antitumor Immunity

Advanced healthcare materials

2026 Mechanism / Preclinical Inhalation

2026 · Zhang — Pearl-Like Bioinspired Coating Enables Regulation of Mg Degradation for Osteoporotic Bone Repair

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2026 Mechanism / Preclinical Inhalation Drinking (HRW)

2026 · Qin — Tumor Microenvironment-Responsive Hydrogen-Generating Zn-Doped ReZIF-8 Nanoplatform for Enhanced Tumor Suppression

Advanced healthcare materials

2025 Mechanism / Preclinical Inhalation

2025 · Wang — Spontaneous Hydrogen-releasing Nanoenzyme Alleviates Osteoarthritis via Oxidative Stress Reduction and Mitochondrial Dysfunction Reversal

Journal of nanobiotechnology

2025 Mechanism / Preclinical Inhalation

2025 · Maier — Biomechanical Analysis of Biodegradable Magnesium, Zinc, and Polylactide Pins for Fixation of Radial Head Fractures

Journal of orthopaedic surgery and research

2025 Mechanism / Preclinical Inhalation

2025 · Yin — Research on the Inhibitory Effect of Hydrogen Gas on Ovarian Cancer and Potential Mechanisms

European journal of medical research

2025 Mechanism / Preclinical Inhalation

2025 · Wang — Hierarchical ROS-scavenging platform breaks vicious cycle of stem cell senescence, angiogenesis arrest, and immune dysregulation in diabetic wounds.

Journal of controlled release : official journal of the Controlled Release Society

2025 Mechanism / Preclinical Inhalation

2025 · Lu — Pyroptosis-responsive microspheres modulate the inflammatory microenvironment to retard osteoporosis in female mice.

Nature communications

2025 Mechanism / Preclinical Inhalation

2025 · Zhang — Hydrogen attenuates the senescence of adipose-derived stem cells and enhances their myogenic differentiation via modulation of the PRDX6/SIRT1/PGC-1α signaling pathway.

Human & experimental toxicology

2025 Mechanism / Preclinical Inhalation

2025 · Zhang — RNA-Seq Reveals the Mechanism of Synergistic Hydrogen-Chemotherapy Based on Active Magnesium Micromotors for Inhibiting Glioblastoma Recurrence by Modulating Tumor Microenvironment.

Small (Weinheim an der Bergstrasse, Germany)

2025 Mechanism / Preclinical Inhalation

2025 · Lu — Dietary addition of magnesium hydride nanoparticles: a breakthrough in combating high-fat diet-induced chronic kidney disease.

Medical gas research

2025 Mechanism / Preclinical Inhalation Drinking (HRW)

2025 · Liu — Hydrogen-induced disruption of the airway mucus barrier enhances nebulized RNA delivery to reverse pulmonary fibrosis.

Science advances

2025 Mechanism / Preclinical Inhalation

2025 · Du — A partially degradable composite consisting of Ti-Zr-Cu-Pd-Sn metallic glass and Fe-Mg alloy for orthopedic applications.

Acta biomaterialia

2025 Mechanism / Preclinical Inhalation

2025 · Lin — Galvanic Cell Bipolar Microneedle Patches for Reversing Photoaging Wrinkles.

Advanced materials (Deerfield Beach, Fla.)

2025 Mechanism / Preclinical Inhalation

2025 · Mancebo — Performance of Unmodified Mechanical Ventilators With 2% Hydrogen Gas Mixtures.

Respiratory care

2025 Mechanism / Preclinical Inhalation

2025 · Yang — Manganese Galvanic Cells Intervene in Tumor Metabolism to Reinforce cGAS-STING Activation for Bidirectional Synergistic Hydrogen-Immunotherapy.

Advanced materials (Deerfield Beach, Fla.)

2025 Mechanism / Preclinical Inhalation

2025 · Ji — Hydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis.

Advanced materials (Deerfield Beach, Fla.)

2025 Mechanism / Preclinical Inhalation

2025 · Hu — Hydrogen-Generating Magnesium Alloy Seed Strand Sensitizes Solid Tumors to Iodine-125 Brachytherapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2025 Mechanism / Preclinical Inhalation

2025 · Zhang — Living Therapeutics for Synergistic Hydrogen-Photothermal Cancer Treatment by Photosynthetic Bacteria.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2025 Mechanism / Preclinical Inhalation

2025 · Ji — Mitochondrial 'Birth-Death' Coordinator: An Intelligent Hydrogen Nanogenerator to Enhance Intervertebral Disc Regeneration

Biomaterials

2025 Mechanism / Preclinical Inhalation

2025 · Tian — Molecular hydrogen attenuates cisplatin-induced nephrotoxicity by modulating β-hydroxybutyrate metabolism

Molecular Biology Reports

2024 Mechanism / Preclinical Inhalation

2024 · Tumurbaatar — The effect of hydrogen gas on the oxidative stress response in adipose tissue.

Scientific reports

2024 Mechanism / Preclinical Inhalation

2024 · McCurry — Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas.

Cell

2024 Mechanism / Preclinical Inhalation

2024 · Chen et al. — Endogenous Melanin and Hydrogen-Based Specific Activated Theranostics Nanoagents: A Novel Multi-Treatment Paradigm for Rheumatoid Arthritis

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2024 Mechanism / Preclinical Inhalation Saline / IV

2024 · Cui et al. — Molecular Hydrogen Attenuates Sepsis-Induced Cardiomyopathy in Mice by Promoting Autophagy

BMC anesthesiology

2024 Mechanism / Preclinical Inhalation

2024 · Cui — High-concentration hydrogen inhalation mitigates sepsis-associated encephalopathy in mice by improving mitochondrial dynamics

CNS Neuroscience & Therapeutics

2024 Mechanism / Preclinical Inhalation

2024 · Wang — Natural hydrogen gas and engineered microalgae prevent acute lung injury in sepsis

Materials Today Bio

2023 Mechanism / Preclinical Inhalation Saline / IV

2023 · Aokage — Attenuation of pulmonary damage in aged lipopolysaccharide-induced inflammation mice through continuous 2 % hydrogen gas inhalation: A potential therapeutic strategy for geriatric inflammation and survival

Experimental gerontology

2023 Mechanism / Preclinical Inhalation

2023 · Liu — Hydrogen gas ameliorates acute alcoholic liver injury via anti-inflammatory and antioxidant effects and regulation of intestinal microbiota

International immunopharmacology

2023 Mechanism / Preclinical Inhalation

2023 · Kiyoi — Intermittent environmental exposure to hydrogen prevents skin photoaging through reduction of oxidative stress

Geriatrics & gerontology international

2023 Mechanism / Preclinical Inhalation

2023 · Son — PdO-Nanoparticle-Embedded Carbon Nanotube Yarns for Wearable Hydrogen Gas Sensing Platforms with Fast and Sensitive Responses

ACS sensors

2023 Mechanism / Preclinical Inhalation

2023 · Iketani — H₂-induced transient upregulation of phospholipids with suppression of energy metabolism

Medical gas research

2023 Mechanism / Preclinical Inhalation

2023 · Kopp — Long-term in vivo observations show biocompatibility and performance of ZX00 magnesium screws surface-modified by plasma-electrolytic oxidation in Göttingen miniature pigs

Acta biomaterialia

2023 Mechanism / Preclinical Inhalation

2023 · Videhult Pierre — Hydrogen Gas Inhalation Attenuates Acute Impulse Noise Trauma: A Preclinical In Vivo Study

The Annals of otology, rhinology, and laryngology

2022 Mechanism / Preclinical Inhalation Bath / Topical

2022 · Yamamoto et al. — Development of a Model System for Gas Cavity Formation Behavior of Magnesium Alloy Implantation

ACS biomaterials science & engineering

2022 Mechanism / Preclinical Inhalation

2022 · Catlett — Metabolic Synergy between Human Symbionts Bacteroides and Methanobrevibacter

Microbiology spectrum

2022 Mechanism / Preclinical Inhalation Drinking (HRW)

2022 · Adzavon — Long-term and daily use of molecular hydrogen induces reprogramming of liver metabolism in rats by modulating NADP/NADPH redox pathways

Scientific reports

2022 Mechanism / Preclinical Inhalation Saline / IV

2022 · Ge — Microbial hydrogen economy alleviates colitis by reprogramming colonocyte metabolism and reinforcing intestinal barrier

Gut microbes

2022 Mechanism / Preclinical Inhalation Drinking (HRW)

2022 · An — Gender-based differences in neuroprotective effects of hydrogen gas against intracerebral hemorrhage-induced depression

Neurochemistry international

2022 Mechanism / Preclinical Inhalation

2022 · Liu — In vivo microelectrode monitoring of real-time hydrogen concentration in different tissues of rats after inhaling hydrogen gas

Medical gas research

2021 Mechanism / Preclinical Inhalation Drinking (HRW)

2021 · Yin et al. — Hydrogen Gas with Extracorporeal Cardiopulmonary Resuscitation Improves Survival after Prolonged Cardiac Arrest in Rats

Journal of translational medicine

2021 Mechanism / Preclinical Inhalation

2021 · Yuan et al. — In Situ Hydrogen Nanogenerator for Bimodal Imaging Guided Synergistic Photothermal/Hydrogen Therapies

Nanoscale

2021 Mechanism / Preclinical Inhalation

2021 · van Gelder et al. — Safety of Electrooxidation for Urea Removal in a Wearable Artificial Kidney Is Compromised by Formation of Glucose Degradation Products

Artificial organs

2021 Mechanism / Preclinical Inhalation

2021 · Spanoghe et al. — Microbial Food from Light, Carbon Dioxide and Hydrogen Gas: Kinetic, Stoichiometric and Nutritional Potential of Three Purple Bacteria

Bioresource technology

2021 Mechanism / Preclinical Inhalation

2021 · Chu — Mechanism of hydrogen on cervical cancer suppression revealed by high-throughput RNA sequencing

Oncology reports

2021 Mechanism / Preclinical Inhalation

2021 · Zhang — Molecular hydrogen alleviates asthma through inhibiting IL-33/ILC2 axis

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

2021 Mechanism / Preclinical Inhalation

2021 · Li — Hydrogen Attenuates Endotoxin-Induced Lung Injury by Activating Thioredoxin 1 and Decreasing Tissue Factor Expression

Frontiers in immunology

2021 Mechanism / Preclinical Inhalation

2021 · Matsuura — Hydrogen Gas Therapy Attenuates Inflammatory Pathway Signaling in Septic Mice

The Journal of surgical research

2021 Mechanism / Preclinical Inhalation Bath / Topical

2021 · Hartjen — Toward Tailoring the Degradation Rate of Magnesium-Based Biomaterials for Various Medical Applications: Assessing Corrosion, Cytocompatibility and Immunological Effects

International journal of molecular sciences

2021 Mechanism / Preclinical Inhalation

2021 · Duffner — Dechloromonas and close relatives prevail during hydrogenotrophic denitrification in stimulated microcosms with oxic aquifer material

FEMS microbiology ecology

2021 Mechanism / Preclinical Inhalation

2021 · Gopi — Cobalt-modified 2D porous organic polymer for highly efficient electrocatalytic removal of toxic urea and nitrophenol

Chemosphere

2021 Mechanism / Preclinical Inhalation Drinking (HRW)

2021 · Ostojic — Does drinking water rich in hydrogen gas revive brain hypometabolism in neurodegeneration by SCFAs upregulation?

European journal of clinical nutrition

2020 Mechanism / Preclinical Inhalation

2020 · Ostojic — COVID-19 and Molecular Hydrogen Inhalation

Therapeutic advances in respiratory disease

2020 Mechanism / Preclinical Inhalation

2020 · De Paepe — Bio-electrochemical COD Removal for Energy-efficient, Maximum and Robust Nitrogen Recovery from Urine through Membrane Aerated Nitrification

Water research

2020 Mechanism / Preclinical Inhalation

2020 · Echeverry-Rendon — Interaction of Different Cell Types with Magnesium Modified by Plasma Electrolytic Oxidation

Colloids and surfaces. B, Biointerfaces

2020 Mechanism / Preclinical Inhalation

2020 · Sun — Photoactivated H₂ Nanogenerator for Enhanced Chemotherapy of Bladder Cancer

ACS nano

2020 Mechanism / Preclinical Inhalation

2020 · Meng — Hydrogen Gas Represses the Progression of Lung Cancer via Down-regulating CD47

Bioscience reports

2020 Mechanism / Preclinical Inhalation Drinking (HRW)

2020 · Kiyoi — Constitutive Hydrogen Inhalation Prevents Vascular Remodeling via Reduction of Oxidative Stress

PloS one

2020 Mechanism / Preclinical Inhalation

2020 · Zhuang — Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway.

International immunopharmacology

2020 Mechanism / Preclinical Inhalation Drinking (HRW)

2020 · Ruaud — Syntrophy via Interspecies H₂ Transfer between Christensenella and Methanobrevibacter Underlies Their Global Cooccurrence in the Human Gut.

mBio

2020 Mechanism / Preclinical Inhalation

2020 · Oh — Untethered Soft Robotics with Fully Integrated Wireless Sensing and Actuating Systems for Somatosensory and Respiratory Functions.

Soft robotics

2019 Mechanism / Preclinical Inhalation

2019 · Chen et al. — Inhaling Hydrogen Ameliorates Early Postresuscitation EEG Characteristics in an Asphyxial Cardiac Arrest Rat Model.

BioMed research international

2019 Mechanism / Preclinical Inhalation

2019 · Jung — In Vivo Simulation of Magnesium Degradability Using a New Fluid Dynamic Bench Testing Approach

International journal of molecular sciences

2019 Mechanism / Preclinical Inhalation

2019 · Kobayashi — Organ Preservation Solution Containing Dissolved Hydrogen Gas from a Hydrogen-Absorbing Alloy Canister Improves Function of Transplanted Ischemic Kidneys in Miniature Pigs

PloS one

2019 Mechanism / Preclinical Inhalation

2019 · Zhang — Hydrogen Gas Improves Photothermal Therapy of Tumor and Restrains the Relapse of Distant Dormant Tumor

Biomaterials

2019 Mechanism / Preclinical Inhalation

2019 · Liu — Molecular Hydrogen Suppresses Glioblastoma Growth via Inducing the Glioma Stem-Like Cell Differentiation

Stem cell research & therapy

2019 Mechanism / Preclinical Inhalation

2019 · Wu — Hydrogen gas protects against ovariectomy-induced osteoporosis by inhibiting NF-κB activation.

Menopause (New York, N.Y.)

2019 Mechanism / Preclinical Inhalation Saline / IV

2019 · Yan — Hydrogen gas inhalation attenuates sepsis-induced liver injury in a FUNDC1-dependent manner.

International immunopharmacology

2019 Mechanism / Preclinical Inhalation

2019 · Liu — In vitro and in vivo studies of Mg-30Sc alloys with different phase structure for potential usage within bone.

Acta biomaterialia

2019 Mechanism / Preclinical Inhalation

2019 · Zhu — Mechanical Strength, Biodegradation, and in Vitro and in Vivo Biocompatibility of Zn Biomaterials.

ACS applied materials & interfaces

2019 Mechanism / Preclinical Inhalation

2019 · Yu — Hydrogen gas reduces HMGB1 release in lung tissues of septic mice in an Nrf2/HO-1-dependent pathway.

International immunopharmacology

2019 Mechanism / Preclinical Inhalation

2019 · Guan — Hydrogen gas reduces chronic intermittent hypoxia-induced hypertension by inhibiting sympathetic nerve activity and increasing vasodilator responses via antioxidation.

Journal of cellular biochemistry

2018 Mechanism / Preclinical Inhalation

2018 · Dong — Protective effects of hydrogen gas against sepsis-induced acute lung injury via regulation of mitochondrial function and dynamics

International immunopharmacology

2018 Mechanism / Preclinical Inhalation

2018 · Perisin — Human gut microbe co-cultures have greater potential than monocultures for food waste remediation to commodity chemicals

Scientific reports

2018 Mechanism / Preclinical Inhalation Saline / IV

2018 · Wan — An In Situ Depot for Continuous Evolution of Gaseous H₂ Mediated by a Magnesium Passivation/Activation Cycle for Treating Osteoarthritis

Angewandte Chemie (International ed. in English)

2018 Mechanism / Preclinical Inhalation

2018 · Wang — Hydrogen gas inhibits lung cancer progression through targeting SMC3

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2017 Mechanism / Preclinical Inhalation Saline / IV

2017 · Watanabe — Protective Effect of Hydrogen Gas Inhalation on Muscular Damage Using a Mouse Hindlimb Ischaemia-Reperfusion Injury Model

Plastic and reconstructive surgery

2017 Mechanism / Preclinical Inhalation

2017 · Asanuma — Translational Study of Hydrogen Gas Inhalation as Adjuncts to Reperfusion Therapy for Acute Myocardial Infarction

Circulation journal : official journal of the Japanese Circulation Society

2017 Mechanism / Preclinical Inhalation Drinking (HRW)

2017 · Murakami — Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis

PloS one

2016 Mechanism / Preclinical Inhalation

2016 · Wang — Hydrogen Metabolism in Helicobacter pylori Plays a Role in Gastric Carcinogenesis through Facilitating CagA Translocation

mBio

2016 Mechanism / Preclinical Inhalation Drinking (HRW)

2016 · Hara — Molecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells

Circulation journal : official journal of the Japanese Circulation Society

2016 Mechanism / Preclinical Inhalation Drinking (HRW)

2016 · Muramatsu — Hydrogen-Rich Water Ameliorates Bronchopulmonary Dysplasia (BPD) in Newborn Rats

Pediatric pulmonology

2016 Mechanism / Preclinical Inhalation

2016 · Iuchi — Molecular Hydrogen Regulates Gene Expression by Modifying the Free Radical Chain Reaction-Dependent Generation of Oxidized Phospholipid Mediators

Scientific reports

2016 Mechanism / Preclinical Inhalation

2016 · Yang — Hydrogen-Rich Medium Ameliorates Lipopolysaccharide-Induced Barrier Dysfunction via RhoA-mDia1 Signaling in Caco-2 Cells

Shock (Augusta, Ga.)

2015 Mechanism / Preclinical Inhalation Drinking (HRW)

2015 · Shi et al. — Hydrogen Therapy Reduces Oxidative Stress-associated Risks Following Acute and Chronic Exposure to High-altitude Environment.

Biomedical and environmental sciences : BES

2015 Mechanism / Preclinical Inhalation

2015 · Keles et al. — Can an innocent toy become dangerous? The hydrogen gas balloon burn.

Burns : journal of the International Society for Burn Injuries

2015 Mechanism / Preclinical Inhalation

2015 · Barbu et al. — The use of hydrogen gas clearance for blood flow measurements in single endogenous and transplanted pancreatic islets.

Microvascular research

2014 Mechanism / Preclinical Inhalation

2014 · Bazaka et al. — Polymer encapsulation of magnesium to control biodegradability and biocompatibility.

Journal of nanoscience and nanotechnology

2014 Mechanism / Preclinical Inhalation

2014 · Nazreen et al. — Thiazolidine-2,4-diones derivatives as PPAR-γ agonists: synthesis, molecular docking, in vitro and in vivo antidiabetic activity with hepatotoxicity risk evaluation.

Bioorganic & medicinal chemistry letters

2014 Mechanism / Preclinical Inhalation Bath / Topical

2014 · Chen — Controlling initial biodegradation of magnesium by a biocompatible strontium phosphate conversion coating

Acta biomaterialia

2013 Mechanism / Preclinical Inhalation

2013 · Johnsen — A non-aqueous reduction process for purifying ¹⁵³Gd produced in natural europium targets

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

2013 Mechanism / Preclinical Inhalation

2013 · Wang et al. — A surface-eroding poly(1,3-trimethylene carbonate) coating for fully biodegradable magnesium-based stent applications.

Acta biomaterialia

2012 Mechanism / Preclinical Inhalation

2012 · Wong et al. — A hydrogen gas-water equilibration method produces accurate and precise stable hydrogen isotope ratio measurements in nutrition studies.

The Journal of nutrition

2012 Mechanism / Preclinical Inhalation Saline / IV

2012 · Takeuchi et al. — Hydrogen may inhibit collagen-induced platelet aggregation: an ex vivo and in vivo study.

Internal medicine (Tokyo, Japan)

2012 Mechanism / Preclinical Inhalation

2012 · Qian et al. — Hydrogen therapy may be an effective and specific novel treatment for aplastic anemia.

Medical science monitor : international medical journal of experimental and clinical research

2012 Mechanism / Preclinical Inhalation Bath / Topical

2012 · Baxter et al. — Evaluation of outgassing, tear strength, and detail reproduction in alginate substitute materials.

Operative dentistry

2011 Mechanism / Preclinical Inhalation

2011 · Terasaki — Hydrogen Therapy Attenuates Irradiation-Induced Lung Damage by Reducing Oxidative Stress

American journal of physiology. Lung cellular and molecular physiology

2011 Mechanism / Preclinical Inhalation Bath / Topical

2011 · Gao — Fabrication and Characterization of Bioactive Composite Coatings on Mg-Zn-Ca Alloy by MAO/Sol-Gel

Journal of materials science. Materials in medicine

2011 Mechanism / Preclinical Inhalation Saline / IV

2011 · Chuai — A Possible Prevention Strategy of Radiation Pneumonitis: Combine Radiotherapy with Aerosol Inhalation of Hydrogen-Rich Solution

Medical science monitor : international medical journal of experimental and clinical research

2011 Mechanism / Preclinical Inhalation

2011 · Chai — Perfusion Electrodeposition of Calcium Phosphate on Additive Manufactured Titanium Scaffolds for Bone Engineering

Acta biomaterialia

2011 Mechanism / Preclinical Inhalation Drinking (HRW)

2011 · Schoenfeld — Hydrogen Therapy May Reduce the Risks Related to Radiation-Induced Oxidative Stress in Space Flight

Medical hypotheses

2010 Mechanism / Preclinical Inhalation Saline / IV Drinking (HRW)

2010 · Liu — Oral administration of mannitol may be an effective treatment for ischemia-reperfusion injury.

Medical hypotheses

2010 Mechanism / Preclinical Inhalation

2010 · Kawasaki — Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving differentiation and paracrine potentials.

Biochemical and biophysical research communications

2010 Mechanism / Preclinical Inhalation Drinking (HRW)

2010 · Bolca — Microbial equol production attenuates colonic methanogenesis and sulphidogenesis in vitro.

Anaerobe

2010 Mechanism / Preclinical Inhalation

2010 · Wong — A biodegradable polymer-based coating to control the performance of magnesium alloy orthopaedic implants.

Biomaterials

2010 Mechanism / Preclinical Inhalation

2010 · Sugiyama — Use of laser speckle flowgraphy in ocular blood flow research.

Acta ophthalmologica

2010 Mechanism / Preclinical Inhalation

2010 · Liu — Hydrogen therapy may be an effective and specific novel treatment for acute radiation syndrome.

Medical hypotheses

2009 Mechanism / Preclinical Inhalation Drinking (HRW)

2009 · Suzuki — Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?

FEBS letters

2009 Mechanism / Preclinical Inhalation

2009 · Kajiya — Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate.

Biochemical and biophysical research communications

2009 Mechanism / Preclinical Inhalation

2009 · Gray-Munro — The mechanism of deposition of calcium phosphate coatings from solution onto magnesium alloy AZ31.

Journal of biomedical materials research. Part A

2008 Mechanism / Preclinical Inhalation

2008 · Song — A role for IOP1 in mammalian cytosolic iron-sulfur protein biogenesis.

The Journal of biological chemistry

2008 Mechanism / Preclinical Inhalation

2008 · Hill — Preliminary tribological evaluation of nanostructured diamond coatings against ultra-high molecular weight polyethylene.

Journal of biomedical materials research. Part B, Applied biomaterials

2008 Mechanism / Preclinical Inhalation

2008 · Kniess et al. — Practical experiences with the synthesis of [¹¹C]CH₃I through gas phase iodination using a TRACERlabFXC synthesis module

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

2007 Mechanism / Preclinical Inhalation

2007 · Ohsawa — Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

Nature Medicine

2005 Mechanism / Preclinical Inhalation

2005 · Decroos et al. — Isolation and characterisation of an equol-producing mixed microbial culture from a human faecal sample and its activity under gastrointestinal conditions

Archives of microbiology

2002 Mechanism / Preclinical Inhalation

2002 · Happe — Hydrogenases in green algae: do they save the algae's life and solve our energy problems?

Trends in plant science

2002 Mechanism / Preclinical Inhalation Drinking (HRW)

2002 · Peterson — Tritium doses from chronic atmospheric releases: a new approach proposed for regulatory compliance.

Health physics

1999 Mechanism / Preclinical Inhalation

1999 · Tomita — Oxygen and hydrogen gas transport through living C6 cell suspensions is faster than that in dead cells.

Advances in experimental medicine and biology

1999 Mechanism / Preclinical Inhalation Saline / IV Drinking (HRW)

1999 · Ishikawa — A preventive effect of a selective endothelin-A receptor antagonist, S-0139, on the erythropoietin-induced reduction of the renal cortical blood flow.

Urological research

1999 Mechanism / Preclinical Inhalation Saline / IV

1999 · Tamori — Role of calcitonin gene-related peptide and capsaicin-sensitive afferents in central thyrotropin-releasing hormone-induced hepatic hyperemia.

European journal of pharmacology

1996 Mechanism / Preclinical Inhalation

1996 · Franić — Radiotoxicity of Tritiated Water and Tritiated Hydrogen

Arhiv za higijenu rada i toksikologiju

1994 Mechanism / Preclinical Inhalation

1994 · Florin — A Possible Role for Bile Acid in the Control of Methanogenesis and the Accumulation of Hydrogen Gas in the Human Colon

Journal of gastroenterology and hepatology

1993 Mechanism / Preclinical Inhalation

1993 · Scrimgeour — A Simplified Method for Deuterium/Hydrogen Isotope Ratio Measurements on Water Samples of Biological Origin

Biological mass spectrometry

1992 Mechanism / Preclinical Inhalation

1992 · Ellies — Crystallographic Changes in Calcium Phosphates During Plasma-Spraying

Biomaterials

1992 Mechanism / Preclinical Inhalation

1992 · Wong — A New Zinc Product for the Reduction of Water in Physiological Fluids to Hydrogen Gas for ²H/¹H Isotope Ratio Measurements

European journal of clinical nutrition

1991 Mechanism / Preclinical Inhalation Drinking (HRW)

1991 · Kawano — Protective Effect of Rebamipide (OPC-12759) on the Gastric Mucosa in Rats and Humans

Nihon yakurigaku zasshi. Folia pharmacologica Japonica

1990 Mechanism / Preclinical Inhalation

1990 · Gibson — Alternative pathways for hydrogen disposal during fermentation in the human colon.

Gut

1990 Mechanism / Preclinical Inhalation

1990 · Mitarai — Correlation between gastric microcirculation and mucosal injury after surgical therapy of esophageal varices.

Nihon Geka Gakkai zasshi

1989 Mechanism / Preclinical Inhalation

1989 · Heizmann — GasPak Plus versus Anaerocult A — two carbon dioxide/hydrogen systems for cultivation of anaerobes.

Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology

1987 Mechanism / Preclinical Inhalation

1987 · Wong — Deuterium and oxygen-18 measurements on microliter samples of urine, plasma, saliva, and human milk.

The American journal of clinical nutrition

1986 Mechanism / Preclinical Inhalation

1986 · Sato — Hemodynamics of the gastric mucosa and gastric ulceration in rats and in patients with gastric ulcer.

Digestive diseases and sciences

1983 Mechanism / Preclinical Inhalation

1983 · Homer — Transient solutions of equations for countercurrent capillary exchange.

The American journal of physiology

1983 Mechanism / Preclinical Inhalation

1983 · Peel — The fatty acyl chain composition of human normal and leukaemic lymphocytes and its modulation by specialised hydrogenation.

Leukemia research

1982 Mechanism / Preclinical Inhalation

1982 · Murakami — Contact electrode method in hydrogen gas clearance technique: a new method for determination of regional gastric mucosal blood flow in animals and humans.

Gastroenterology

1976 Mechanism / Preclinical Inhalation

1976 · Harding — Characterization of Bacteroides melaninogenicus.

Journal of clinical microbiology