Immune / Inflammation

2025 · Xie — Mechanisms and Protective Strategies for Astronaut Skin Injury in Deep Space Environments

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

2025 · Kornieieva — Exploring the Potential of Molecular Hydrogen in Different Heart Failure Models: A Review

International journal of molecular sciences

2025 · Zhu — Molecular mechanisms associated with effects of hydrogen molecule in liver diseases: the review of current evidence

European journal of medical research

2025 · Li — Delivery of Molecular Hydrogen for Precision Immunomodulation: Mechanisms, Detection Methods, and Applications

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2025 · Ye — Molecular hydrogen as a novel regulator of cellular pyroptosis: mechanistic insights and therapeutic implications

Molecular biology reports

2025 · Brandi — Molecular hydrogen therapy: A „democratic” emerging strategy against aging and age-related diseases

Ageing research reviews

2025 · Zajac — Molecular Hydrogen in the Treatment of Respiratory Diseases

International journal of molecular sciences

2025 · Bjørklund — Advanced Glycation End Products and Skin Autoimmune Disorders: Pathogenic Insights into Vitiligo, Bullous Pemphigoid, and Type 1 Diabetes Mellitus

Current medicinal chemistry

2025 · Bilski — Antioxidant Therapies as Emerging Adjuncts in Rheumatoid Arthritis: Targeting Oxidative Stress to Enhance Treatment Outcomes

International journal of molecular sciences

2025 · Sahu — Activation, interaction and intimation of Nrf2 pathway and their mutational studies causing Nrf2 associated cancer

Biochimica et biophysica acta. Molecular basis of disease

2025 · Alaqel — Aging, vascular dysfunction, and the blood-brain barrier: unveiling the pathophysiology of stroke in older adults

Biogerontology

2025 Review / Meta-analysis Inhalation

2025 · Zamanian — The Roles of Neuroinflammation in l-DOPA-Induced Dyskinesia: Dissecting the Roles of NF-κB and TNF-α for Novel Pharmacological Therapeutic Approaches

The European journal of neuroscience

2025 · Neykhonji — Exploring the Potential of H₂ Therapy in Reducing Surgical Complications: A Review on Anti-inflammatory, Antioxidant, and Anti-fibrotic Mechanisms

Current pharmaceutical design

2025 · Meng — Oral Administration of Hydrogen-rich Water: Biomedical Activities, Potential Mechanisms, and Clinical Applications

Current pharmaceutical design

2025 Review / Meta-analysis Inhalation

2025 · Li — Application Trends of Hydrogen-generating Nanomaterials for the Treatment of ROS-related Diseases

Biomaterials science

2025 · Todorović — Hydrogen as an Innovative Nootropic in Health and Disease

Nutrition and health

2024 · Slezák — New Possibilities of the Prevention and Treatment of Cardiovascular Pathologies: The Potential of Molecular Hydrogen in the Reduction of Oxidative Stress

Physiological research

2024 Review / Meta-analysis Inhalation

2024 · Xu — The Landscape of Smart Biomaterial-Based Hydrogen Therapy

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2024 · Kura — The Protective Role of Molecular Hydrogen in Ischemia/Reperfusion Injury

International journal of molecular sciences

2024 · Zheng — Potential Role of Molecular Hydrogen Therapy on Oxidative Stress and Redox Signaling in Chronic Kidney Disease

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024 · Hu — The Molecular Biological Mechanism of Hydrogen Therapy and Its Application in Spinal Cord Injury

Drug design, development and therapy

2024 · Khiji — The Therapeutic Application of Hydrogen in Cancer: The Potential and Challenges

Current pharmaceutical design

2024 · Chen — The Role of Hydrogen in the Prevention and Treatment of Coronary Atherosclerotic Heart Disease

European journal of pharmacology

2024 Review / Meta-analysis Inhalation

2024 · Takefuji — Hydrogen Inhalation Therapy for Inflammation and Eye Diseases: A Review of the Literature

Eye (London, England)

2023 · Mohd Noor — A Systematic Review of Molecular Hydrogen Therapy in Cancer Management

Asian Pacific Journal of Cancer Prevention

2023 Review / Meta-analysis Inhalation Saline / IV Bath / Topical Drinking (HRW)

2023 · He et al. — The Role of Hydrogen Therapy in Alzheimer's Disease Management: Insights into Mechanisms, Administration Routes, and Future Challenges

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 · Saengsin et al. — Hydrogen Therapy as a Potential Therapeutic Intervention in Heart Disease: From the Past Evidence to Future Application

Cellular and molecular life sciences : CMLS

2023 · Bellucci et al. — Novel Therapeutic Approaches Based on the Pathological Role of Gut Dysbiosis on the Link Between Non-Alcoholic Fatty Liver Disease and Insulin Resistance

European review for medical and pharmacological sciences

2023 · Wu et al. — Molecular Hydrogen: An Emerging Therapeutic Medical Gas for Brain Disorders

Molecular neurobiology

2023 Review / Meta-analysis Inhalation Drinking (HRW)

2023 · Li — Trend of research on the medical use of molecular hydrogen: a bibliometric analysis

Medical gas research

2022 · Fu — Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases

Oxidative medicine and cellular longevity

2022 · Zhang et al. — Molecular Hydrogen Is a Potential Protective Agent in the Management of Acute Lung Injury

Molecular medicine (Cambridge, Mass.)

2022 · Ahmad et al. — Narrative on Hydrogen Therapy and its Clinical Applications: Safety and Efficacy

Current pharmaceutical design

2022 · Fu — Molecular hydrogen is a promising therapeutic agent for pulmonary disease

Journal of Zhejiang University. Science. B

2021 · Tallima — Cell surface sphingomyelin: key role in cancer initiation, progression, and immune evasion.

Lipids in health and disease

2021 · Alwazeer — Combating Oxidative Stress and Inflammation in COVID-19 by Molecular Hydrogen Therapy: Mechanisms and Perspectives.

Oxidative medicine and cellular longevity

2021 · Hirano — Molecular Hydrogen as a Novel Antitumor Agent: Possible Mechanisms Underlying Gene Expression.

International journal of molecular sciences

2021 · Yamamoto — Molecular Hydrogen as a Novel Protective Agent against Pre-Symptomatic Diseases.

International journal of molecular sciences

2021 Review / Meta-analysis Inhalation Saline / IV Bath / Topical Drinking (HRW)

2021 · Hirano — Molecular Hydrogen as a Potential Clinically Applicable Radioprotective Agent.

International journal of molecular sciences

2021 · Quan — Protective effects of molecular hydrogen on lung injury from lung transplantation.

Experimental biology and medicine (Maywood, N.J.)

2021 · Hirano — Potential Therapeutic Applications of Hydrogen in Chronic Inflammatory Diseases: Possible Inhibiting Role on Mitochondrial Stress.

International journal of molecular sciences

2021 · Shi et al. — Hydrogen treatment: a novel option in liver diseases.

Clinical medicine (London, England)

2021 Review / Meta-analysis Inhalation

2021 · Chen et al. — Chemical and Biochemical Aspects of Molecular Hydrogen in Treating Kawasaki Disease and COVID-19.

Chemical research in toxicology

2021 Review / Meta-analysis Inhalation Bath / Topical

2021 · Zhang et al. — Hydrogen Gas: A Novel Type of Antioxidant in Modulating Sexual Organs Homeostasis.

Oxidative medicine and cellular longevity

2021 Review / Meta-analysis Inhalation Saline / IV

2021 · Sano et al. — Hydrogen Gas Therapy: From Preclinical Studies to Clinical Trials.

Current pharmaceutical design

2021 · Domoki — Hydrogen-induced Neuroprotection in Neonatal Hypoxic-ischemic Encephalopathy.

Current pharmaceutical design

2021 · Nogueira et al. — Recent Advances in Molecular Hydrogen Research Reducing Exercise-Induced Oxidative Stress and Inflammation.

Current pharmaceutical design

2021 · Li et al. — Recent advances in studies of molecular hydrogen in the treatment of pancreatitis.

Life sciences

2021 · Chen et al. — Neuroprotective Effects of Molecular Hydrogen: A Critical Review.

Neuroscience bulletin

2021 · Bajgai et al. — Role of Molecular Hydrogen in Skin Diseases and its Impact in Beauty.

Current pharmaceutical design

2021 · Ohta — Direct Targets and Subsequent Pathways for Molecular Hydrogen to Exert Multiple Functions: Focusing on Interventions in Radical Reactions

Current pharmaceutical design

2021 Review / Meta-analysis Inhalation Saline / IV Drinking (HRW)

2021 · Ostojic — Hydrogen Gas as an Exotic Performance-Enhancing Agent: Challenges and Opportunities

Current pharmaceutical design

2021 · Slezak et al. — Oxidative Stress and Pathways of Molecular Hydrogen Effects in Medicine

Current pharmaceutical design

2020 Review / Meta-analysis Inhalation

2020 · Chen et al. — The future of cryoablation: An abscopal effect

Cryobiology

2019 Review / Meta-analysis Inhalation

2019 · Qian — Medical Application of Hydrogen in Hematological Diseases.

Oxidative medicine and cellular longevity

2019 · Morris — Myalgic encephalomyelitis/chronic fatigue syndrome: From pathophysiological insights to novel therapeutic opportunities.

Pharmacological research

2019 Review / Meta-analysis Inhalation Saline / IV Drinking (HRW)

2019 · LeBaron et al. — A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress.

Molecules (Basel, Switzerland)

2019 Review / Meta-analysis Drinking (HRW)

2019 · Ishibashi — Therapeutic Efficacy of Molecular Hydrogen: A New Mechanistic Insight.

Current pharmaceutical design

2019 Review / Meta-analysis Inhalation Drinking (HRW)

2019 · LeBaron et al. — Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes.

Canadian journal of physiology and pharmacology

2019 · Cejka et al. — The preventive and therapeutic effects of molecular hydrogen in ocular diseases and injuries where oxidative stress is involved.

Free radical research

2019 · Kura et al. — Molecular hydrogen: potential in mitigating oxidative-stress-induced radiation injury.

Canadian journal of physiology and pharmacology

2019 Review / Meta-analysis Inhalation

2019 · Li et al. — Hydrogen as a complementary therapy against ischemic stroke: A review of the evidence.

Journal of the neurological sciences

2019 Review / Meta-analysis Saline / IV

2019 · Wang et al. — Neonatal hypoxic-ischemic encephalopathy: emerging therapeutic strategies based on pathophysiologic phases of the injury.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2015 Review / Meta-analysis Inhalation Saline / IV Bath / Topical Drinking (HRW)

2019 · Tao et al. — Molecular hydrogen: current knowledge on mechanism in alleviating free radical damage and diseases.

Acta biochimica et biophysica Sinica

2019 Review / Meta-analysis Inhalation

2019 · Wu — Hydrogen Gas from Inflammation Treatment to Cancer Therapy

ACS nano

2018 Review / Meta-analysis Unspecified

2018 · Morris — The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders

Sleep medicine reviews

2016 Review / Meta-analysis Unspecified

2016 · Slezák — Preventive and Therapeutic Application of Molecular Hydrogen in Situations with Excessive Production of Free Radicals

Physiological research

2016 Review / Meta-analysis Unspecified

2016 · Zheng — Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis

Oxidative medicine and cellular longevity

2015 Review / Meta-analysis Unspecified

2015 · Ostojic — Molecular hydrogen: An inert gas turns clinically effective.

Annals of medicine

2015 · Ohta — Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications.

Methods in enzymology

2015 Review / Meta-analysis Unspecified

2015 · Ostojic — Molecular hydrogen in sports medicine: new therapeutic perspectives.

International journal of sports medicine

2014 Review / Meta-analysis Inhalation

2014 · Xie et al. — Hydrogen gas presents a promising therapeutic strategy for sepsis.

BioMed research international

2014 Review / Meta-analysis Inhalation Saline / IV Bath / Topical Drinking (HRW)

2014 · Ohta — Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine.

Pharmacology & therapeutics

2014 Review / Meta-analysis Saline / IV

2014 · Fernández-Gajardo et al. — Novel therapeutic strategies for traumatic brain injury: acute antioxidant reinforcement.

CNS drugs

2013 Review / Meta-analysis Drinking (HRW)

2013 · Takaki — Multiple hits, including oxidative stress, as pathogenesis and treatment target in non-alcoholic steatohepatitis (NASH)

International journal of molecular sciences

2013 Review / Meta-analysis Unspecified

2013 · Ishibashi — Molecular hydrogen: new antioxidant and anti-inflammatory therapy for rheumatoid arthritis and related diseases

Current pharmaceutical design

2013 Review / Meta-analysis Inhalation

2013 · Lucas — Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway

Molecular neurobiology

2012 Review / Meta-analysis Drinking (HRW)

2012 · Ohno et al. — Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases.

Oxidative medicine and cellular longevity

2012 Review / Meta-analysis Inhalation

2012 · Carbonero et al. — Contributions of the microbial hydrogen economy to colonic homeostasis.

Nature reviews. Gastroenterology & hepatology

2012 Review / Meta-analysis Inhalation Saline / IV Bath / Topical Drinking (HRW)

2012 · Ohta — Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases.

Biochimica et biophysica acta

2011 Review / Meta-analysis Inhalation Saline / IV Bath / Topical Drinking (HRW)

2011 · Ohta — Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications.

Current pharmaceutical design

2011 Review / Meta-analysis Unspecified

2011 · Noda et al. — The principle and the potential approach to ROS-dependent cytotoxicity by non-pharmaceutical therapies: optimal use of medical gases with antioxidant properties.

Current pharmaceutical design

2011 Review / Meta-analysis Inhalation

2011 · Zheng et al. — Hydrogen resuscitation, a new cytoprotective approach.

Clinical and experimental pharmacology & physiology

2011 Review / Meta-analysis Drinking (HRW)

2011 · Acuña Castroviejo — Melatonin-Mitochondria Interplay in Health and Disease

Current topics in medicinal chemistry

2010 Review / Meta-analysis Unspecified

2010 · Hong — Research Advances on Hydrogen Therapy in Nervous System Diseases

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences

2010 Review / Meta-analysis Inhalation

2010 · Shen — Hydrogen as a novel and effective treatment of acute carbon monoxide poisoning.

Medical hypotheses

2026 RCT Human H₂ therapy Drinking (HRW)

2026 · Stolecka-Warzecha — Redox Water Consumption Attenuates Exercise-Induced Inflammation and Oxidative Stress in Physically Active Adults: A Randomized Controlled Trial

Nutrients

2026 RCT Human H₂ therapy Drinking (HRW)

2026 · Kuang — Exploratory Evaluation of Hydrogen-Rich Water Therapy for Keloid Management: A Double-Blinded Randomized Pilot Trial

Aesthetic Plastic Surgery

2025 RCT Human H₂ therapy Drinking (HRW)

2025 · Zhang — Hydrogen-rich water supplementation attenuates oxidative stress and inflammation in chronic high-altitude disease patients: A double-blind randomized placebo-controlled study

Food Research International

2024 RCT Human H₂ therapy Drinking (HRW)

2024 · Tan — The Effect of 14-Day Consumption of Hydrogen-Rich Water Alleviates Fatigue but Does Not Ameliorate Dyspnea in Long-COVID Patients: A Pilot, Single-Blind, and Randomized, Controlled Trial

Nutrients

2022 RCT Human H₂ therapy Inhalation

2022 · Botek — Molecular Hydrogen Positively Affects Physical and Respiratory Function in Acute Post-COVID-19 Patients: A New Perspective in Rehabilitation

International Journal of Environmental Research and Public Health

2020 RCT Human H₂ therapy Drinking (HRW)

2020 · Dobashi et al. — Hydrogen-rich water suppresses the reduction in blood total antioxidant capacity induced by 3 consecutive days of severe exercise in physically active males.

Medical gas research

2016 RCT Human H₂ therapy Inhalation

2016 · Gong et al. — Protective effect of hydrogen on the lung of sanitation workers exposed to haze.

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases

2014 RCT Human H₂ therapy Tablets Bath / Topical Drinking (HRW)

2014 · Ostojic et al. — Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries.

Postgraduate medicine

2014 RCT Human H₂ therapy Saline / IV

2014 · Ishibashi et al. — Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study.

International immunopharmacology

2026 Pilot / Observational Human H₂ therapy Inhalation Bath / Topical

2026 · Pozdnyakova — The combined use of inhaled nitric oxide and molecular hydrogen in patients with post-COVID-19 syndrome

Terapevticheskii arkhiv

2026 Pilot / Observational Human H₂ therapy Drinking (HRW)

2026 · Li — Adjunctive Molecular Hydrogen Capsule Therapy in Empyema Complicated by Chronic Inflammatory Demyelinating Polyneuropathy: A Case Report

In vivo (Athens, Greece)

2026 Pilot / Observational Human H₂ therapy Saline / IV

2026 · Xu et al. — Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via Promoting Mitophagy

Journal of diabetes

2026 Pilot / Observational Human H₂ therapy Saline / IV Drinking (HRW)

2026 · Lin et al. — Adjunctive Molecular Hydrogen Therapy Modulates T Cell Markers and Reduces Anti-Ro Antibody in Refractory Oral Ulcers of Behçet's Disease and Sjögren's Syndrome: A Case Report

In vivo (Athens, Greece)

2026 Pilot / Observational Human H₂ therapy Inhalation Bath / Topical

2025 · Moriya et al. — Hydrogen Inhalation Is Associated With a Transient Rightward Shift in Prefrontal Oxyhemoglobin Asymmetry and Autonomic Modulation

Scientific reports

2026 Pilot / Observational Human H₂ therapy Drinking (HRW)

2026 · Tsai et al. — Rhupus Syndrome With Multiple Drug Intolerances Managed by Reduced-dose Rituximab and Adjunctive Molecular Hydrogen Therapy: A Case Report

In vivo (Athens, Greece)

2026 Pilot / Observational Human H₂ therapy Unspecified

2026 · Liu et al. — Adjuvant Molecular Hydrogen Therapy in SLE-associated Pulmonary Arterial Hypertension: A Case Report on Immunomodulatory Effects on Regulatory and Effector Lymphocytes

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Drinking (HRW)

2025 · Ren et al. — A Case Report of Adjuvant Molecular Hydrogen Therapy in Refractory Rheumatoid Arthritis With Atlantoaxial Subluxation

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Liu et al. — Dynamic Immunomodulation by Hydrogen Capsule Therapy in SLE-associated Pulmonary Arterial Hypertension: A Case Report

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Drinking (HRW)

2025 · Tu et al. — Immunomodulatory Effects of Molecular Hydrogen Therapy in Systemic Lupus Erythematosus With Pericarditis and Pleuritis: A Case Report

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Drinking (HRW)

2025 · Wong et al. — Nano-Bubble Hydrogen Water in Wet-Wrap Dressing Improves the Severity of Pediatric Patients With Atopic Dermatitis

Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners

2025 Pilot / Observational Human H₂ therapy Drinking (HRW)

2025 · Lui et al. — Predicting Therapeutic Response to Molecular Hydrogen in Autoimmune Diseases via Immunophenotyping

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

2025 Pilot / Observational Human H₂ therapy Drinking (HRW)

2025 · Tu et al. — Molecular Hydrogen Therapy in Rheumatoid Arthritis: A Case Report on the Amelioration of Methotrexate-induced Myelosuppression and Immune Modulation

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Tsai et al. — Molecular Hydrogen as an Adjuvant Therapy in Comorbid Sjögren's Syndrome, SLE, and ILD: A Case Report on Immune Modulation and Fatigue Reduction

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Lin et al. — Molecular Hydrogen Capsule Therapy for Primary Biliary Cholangitis With Elevated IgG4: A Case Report on Immune Marker Normalization

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Hsu et al. — Molecular Hydrogen Therapy Enhances Immune Markers in Treg, Plasma, Tr1 Cells, and KLRG1 Expression on Tc Cells: A Case of Acute SDH With Midline Shift and Uncal Herniation Post-decompressive Craniectomy

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Tu et al. — Molecular Hydrogen Therapy for SLE-PAH: Case Report on Immune Marker Modulation

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Lin et al. — Molecular Hydrogen as an Adjuvant Therapy in Severe Lupus Serositis With Heart Failure: A Case Report on Immune Modulation and Fatigue Reduction

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Saline / IV

2025 · Kuang et al. — Hydrogen-Rich Saline Combined With Vacuum Sealing Drainage Promotes Wound Healing by Altering Biotin Metabolism

Journal of cellular and molecular medicine

2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Lin et al. — Molecular Hydrogen as a Potential Adjunctive Therapy to Improve Renal Function and Reduce Fatigue in an Elderly Patient With Chronic Comorbidities: A Case Report

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Saline / IV

2025 · Lin et al. — Precision Assessment of Anti-NMDA Receptor Encephalitis: A Case Report on Integrating Clinical Course, Immunophenotyping, and Comprehensive Symptomatology in a Pediatric Patient With Adjunctive Hydrogen Therapy

In vivo (Athens, Greece)

2024 Pilot / Observational Human H₂ therapy Inhalation Bath / Topical

2024 · Salomez-Ihl — H2 inhalation therapy in patients with moderate COVID-19 (H2COVID): a prospective ascending-dose phase I clinical trial

Antimicrobial Agents and Chemotherapy

2024 Pilot / Observational Human H₂ therapy Drinking (HRW)

2024 · Lu — Using oral molecular hydrogen supplements to combat microinflammation in humans: a pilot observational study

International Journal of Medical Sciences

2024 Pilot / Observational Human H₂ therapy Drinking (HRW)

2024 · Chen — Molecular Hydrogen Therapy in Aneurysmal SAH With RA and Newly-diagnosed SLE, Complicated With Acute Ischemic Infarction: A Case Report of Improved Immune Markers Including Tr1 Cells, Breg Cells and TIM3 Expression on Tc Cells.

In vivo (Athens, Greece)

2024 Pilot / Observational Human H₂ therapy Unspecified

2024 · Lin — Molecular Hydrogen Therapy in Sjögren's Syndrome With Pulmonary Arterial Hypertension and Right-sided Heart Failure: A Case Report of Improved Immune Markers Including Treg, B Cells and Plasma Cell.

In vivo (Athens, Greece)

2024 Pilot / Observational Human H₂ therapy Unspecified

2024 · Lui — Molecular Hydrogen as a Promising Therapy Could Be Linked With Increased Resting Treg Cells or Decreased Fas+ T Cell Subsets in a IgG4-PF-ILD Patient: A Case Report.

In vivo (Athens, Greece)

2024 Pilot / Observational Human H₂ therapy Inhalation

2024 · Liu — The Benefit of Hydrogen Gas as an Adjunctive Therapy for Chronic Obstructive Pulmonary Disease.

Medicina (Kaunas, Lithuania)

2023 Pilot / Observational Human H₂ therapy Tablets Drinking (HRW)

2023 · Sumbalová — The Effect of Adjuvant Therapy with Molecular Hydrogen on Endogenous Coenzyme Q10 Levels and Platelet Mitochondrial Bioenergetics in Patients with Non-Alcoholic Fatty Liver Disease.

International journal of molecular sciences

2023 Pilot / Observational

2023 · Campbell — H2 generated by fermentation in the human gut microbiome influences metabolism and competitive fitness of gut butyrate producers.

Microbiome

2022 Pilot / Observational Human H₂ therapy Bath / Topical

2022 · Tanaka — Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity and inflammation levels in human serum

Medical gas research

2022 Pilot / Observational

2022 · Aoki — Molecular hydrogen has a positive impact on pregnancy maintenance through enhancement of mitochondrial function and immunomodulatory effects on T cells

Life Sciences

2021 Pilot / Observational Human H₂ therapy Inhalation

2021 · Hirano — Protective effects of hydrogen gas inhalation on radiation-induced bone marrow damage in cancer patients: a retrospective observational study

Medical Gas Research

2021 Pilot / Observational Human H₂ therapy Inhalation

2021 · Kaibori — Effect of hydrogen gas inhalation on patient QOL after hepatectomy: protocol for a randomised controlled trial

Trials

2021 Pilot / Observational Human H₂ therapy Drinking (HRW)

2021 · Si — Effects of hydrogen as adjuvant treatment for unstable angina

Experimental biology and medicine (Maywood, N.J.)

2021 Pilot / Observational Human H₂ therapy Inhalation

2021 · Chen — High-flow hydrogen inhalation might suppress the immune function of middle-aged participants: a self-controlled study

Medical gas research

2020 Pilot / Observational Human H₂ therapy Drinking (HRW)

2020 · Qian — Hydrogen in Patients With Corticosteroid-Refractory/Dependent Chronic Graft-Versus-Host-Disease: A Single-Arm, Multicenter, Open-Label, Phase 2 Trial

Frontiers in Immunology

2020 Pilot / Observational Human H₂ therapy Inhalation

2020 · Chen — Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system senescence in patients with advanced non-small cell lung cancer: a self-controlled study

Medical Gas Research

2020 Pilot / Observational Human H₂ therapy Inhalation

2020 · Wang et al. — Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients.

QJM : monthly journal of the Association of Physicians

2020 Pilot / Observational Human H₂ therapy Drinking (HRW)

2020 · Javorac et al. — Case Report: Acute hydrotherapy with super-saturated hydrogen-rich water for ankle sprain in a professional athlete.

F1000Research

2019 Pilot / Observational Human H₂ therapy Inhalation

2019 · Chen et al. — „Real world survey“ of hydrogen-controlled cancer: a follow-up report of 82 advanced cancer patients.

Medical gas research

2019 Pilot / Observational Human H₂ therapy Drinking (HRW)

2019 · Yang et al. — Skin ulcers infected with conditional pathogenic strains treated with local hydrogen water packing in two pemphigus vulgaris patients: Case reports with follow-up for 2 months.

Dermatologic therapy

2018 Pilot / Observational Human H₂ therapy Bath / Topical Drinking (HRW)

2018 · Zhu — Positive Effects of Hydrogen-Water Bathing in Patients of Psoriasis and Parapsoriasis en Plaques

Scientific reports

2018 Pilot / Observational Human H₂ therapy Unspecified

2018 · Nakayama — Novel Haemodialysis Treatment Employing Molecular Hydrogen-Enriched Dialysis Solution Improves Prognosis of Chronic Dialysis Patients: A Prospective Observational Study

Scientific reports

2017 Pilot / Observational Human H₂ therapy Unspecified

2017 · Nakayama et al. — Possible clinical effects of molecular hydrogen (H₂) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation.

PloS one

2017 Pilot / Observational Human H₂ therapy Saline / IV

2017 · Qian et al. — Therapeutic effects of hydrogen on chronic graft-versus-host disease.

Journal of cellular and molecular medicine

2015 Pilot / Observational Human H₂ therapy Inhalation Saline / IV Drinking (HRW)

2015 · Ishibashi et al. — Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases.

Molecular medicine reports

2010 Pilot / Observational Human H₂ therapy Inhalation

2010 · Nakayama et al. — A Novel Bioactive Haemodialysis System Using Dissolved Dihydrogen (H₂) Produced by Water Electrolysis: A Clinical Trial

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2007 Pilot / Observational

2007 · Maev et al. — Blood Flow and Morphofunctional Status of Gastroduodenal Mucosa in Different Phases of Peptic Ulcer

Terapevticheskii arkhiv

2006 Pilot / Observational Human H₂ therapy Unspecified

2006 · Huang et al. — Electrolyzed-Reduced Water Reduced Hemodialysis-Induced Erythrocyte Impairment in End-Stage Renal Disease Patients

Kidney international

2005 Pilot / Observational

2005 · Sobko et al. — Birth-Related Increase in Intracolonic Hydrogen Gas and Nitric Oxide as Indicator of Host-Microbial Interactions

Allergy

2003 Pilot / Observational Human H₂ therapy Drinking (HRW)

2003 · Huang — Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water.

Kidney international

2026 Mechanism / Preclinical Inhalation

2026 · Wang — Hydrogen gas inhalation alleviated cerebral ischemia/reperfusion injury by regulating mitophagy in SH-SY5Y cells and mice via PTEN-induced kinase 1/Parkin pathway.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

2026 Mechanism / Preclinical Drinking (HRW)

2026 · Yang — Molecular hydrogen suppresses gut inflammation and pyroptosis in ulcerative colitis through promoting PKM2 lactylation to block NLRP3 inflammasome activation.

International immunopharmacology

2026 Mechanism / Preclinical Unspecified

2026 · Zhu — Self-Adaptive Hydrogen Nano-Delivery System in Glaucoma Management: Synergistic Antioxidation and Anti-inflammation Therapeutic Strategy

ACS nano

2026 Mechanism / Preclinical Unspecified

2026 · Bordoni — Ru-Based NSAIDs as Potential Anticancer Therapeutics

Molecules (Basel, Switzerland)

2026 Mechanism / Preclinical Unspecified

2026 · Zhang — Sub-nano Molybdenum Oxide Nanorings as Amplified Atomic Efficiency Sonosensitizers for Highly Efficient Sonodynamic Tumor Ablation

Nanoscale

2026 Mechanism / Preclinical Inhalation Drinking (HRW)

2026 · Jiao — Therapeutic Potential of Magnesium Diboride Nanosheets in PAH-Associated Right Heart Failure: Integrated Multi-Omics Analysis Reveals Ferroptosis Suppression via LC3/ATG5/NCOA4/FTH1 Pathway

Free radical biology & medicine

2026 Mechanism / Preclinical Inhalation Drinking (HRW)

2026 · Qin — Tumor Microenvironment-Responsive Hydrogen-Generating Zn-Doped ReZIF-8 Nanoplatform for Enhanced Tumor Suppression

Advanced healthcare materials

2025 · Chu — Hydrogen Enhanced Photothermal Therapy for Redox-regulated Tumor Apoptosis and Immune Reprogramming

Acta biomaterialia

2025 Mechanism / Preclinical Bath / Topical

2025 · Zhu — Transdermal Hydrogen Therapy for Psoriasis Using Cavity-embedded Double-conical Microneedles

Journal of controlled release : official journal of the Controlled Release Society

2025 · Wang — Spontaneous Hydrogen-releasing Nanoenzyme Alleviates Osteoarthritis via Oxidative Stress Reduction and Mitochondrial Dysfunction Reversal

Journal of nanobiotechnology

2025 · Wang — Hierarchical ROS-scavenging platform breaks vicious cycle of stem cell senescence, angiogenesis arrest, and immune dysregulation in diabetic wounds.

Journal of controlled release : official journal of the Controlled Release Society

2025 Mechanism / Preclinical Drinking (HRW)

2025 · Cao — Nanobiocatalyst-Driven Spatiotemporal Hydrogen Delivery Induces Dormancy Potentiated Catalytic Tumor Therapy.

ACS nano

2025 · Lu — Pyroptosis-responsive microspheres modulate the inflammatory microenvironment to retard osteoporosis in female mice.

Nature communications

2025 · Liu — Local Delivery of Molecular Hydrogen by Fluorinated Zeolitic Imidazole Framework Nanosheets Boosts Cancer Immunotherapy.

ACS applied materials & interfaces

2025 · Huang — Magnesium hydride-induced hydrogen therapy for enhanced sonodynamic therapy.

Materials horizons

2025 · Zhang — RNA-Seq Reveals the Mechanism of Synergistic Hydrogen-Chemotherapy Based on Active Magnesium Micromotors for Inhibiting Glioblastoma Recurrence by Modulating Tumor Microenvironment.

Small (Weinheim an der Bergstrasse, Germany)

2025 · Lu — Dietary addition of magnesium hydride nanoparticles: a breakthrough in combating high-fat diet-induced chronic kidney disease.

Medical gas research

2025 · Lin — Galvanic Cell Bipolar Microneedle Patches for Reversing Photoaging Wrinkles.

Advanced materials (Deerfield Beach, Fla.)

2025 · Mancebo — Performance of Unmodified Mechanical Ventilators With 2% Hydrogen Gas Mixtures.

Respiratory care

2025 · Zhang — Ternary Schottky Junction for Sonocatalytic Water Splitting in Gas-Immunotherapy-Mediated Cancer Treatment.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2025 · Yu — Protective Effects of Hydrogen Treatment Against High Glucose-Induced Oxidative Stress and Apoptosis via Inhibition of the AGEs/RAGE/NF-κB Signaling Pathway in Skin Cells.

Endocrine, metabolic & immune disorders drug targets

2025 · Yang — Manganese Galvanic Cells Intervene in Tumor Metabolism to Reinforce cGAS-STING Activation for Bidirectional Synergistic Hydrogen-Immunotherapy.

Advanced materials (Deerfield Beach, Fla.)

2024 · Li — Hydrogen-rich water alleviates asthma airway inflammation by modulating tryptophan metabolism and activating aryl hydrocarbon receptor via gut microbiota regulation.

Free radical biology & medicine

2024 Mechanism / Preclinical Unspecified

2024 · Xu — Poly(ionic liquid)-Flocculated Chlorella Loading Bactericidal and Antioxidant Hydrogel as a Biological Hydrogen Therapy for Diabetic Wound Dressing.

ACS applied materials & interfaces

2024 Mechanism / Preclinical Unspecified

2024 · Lin — Hydrogen-treated CoCrMo alloy: a novel approach to enhance biocompatibility and mitigate inflammation in orthopedic implants.

Journal of materials chemistry. B

2024 Mechanism / Preclinical Unspecified

2024 · Meng — Hydrogen Therapy Reverses Cancer-Associated Fibroblasts Phenotypes and Remodels Stromal Microenvironment to Stimulate Systematic Anti-Tumor Immunity.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2024 Mechanism / Preclinical Drinking (HRW)

2024 · Wang — Combined use of hydrogen-rich water and enzyme-digested edible bird's nest improves PMA/LPS-impaired wound healing in human inflammatory gingival tissue equivalents.

Human cell

2024 Mechanism / Preclinical Inhalation

2024 · Chen et al. — Endogenous Melanin and Hydrogen-Based Specific Activated Theranostics Nanoagents: A Novel Multi-Treatment Paradigm for Rheumatoid Arthritis

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2024 Mechanism / Preclinical Drinking (HRW)

2024 · Lu et al. — Decoupling the Mutual Promotion of Inflammation and Oxidative Stress Mitigates Cognitive Decline and Depression-Like Behavior in rmTBI Mice by Promoting Myelin Renewal and Neuronal Survival

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024 Mechanism / Preclinical Inhalation Saline / IV

2024 · Cui et al. — Molecular Hydrogen Attenuates Sepsis-Induced Cardiomyopathy in Mice by Promoting Autophagy

BMC anesthesiology

2023 · Agar — The Inhibition Mechanism of Pancreatic Ductal Adenocarcinoma via LXR Receptors: A Multifaceted Approach Integrating Molecular Docking, Molecular Dynamics and Post-MD Inter-Molecular Contact Analysis

Asian Pacific journal of cancer prevention : APJCP

2023 Mechanism / Preclinical Inhalation Saline / IV

2023 · Aokage — Attenuation of pulmonary damage in aged lipopolysaccharide-induced inflammation mice through continuous 2 % hydrogen gas inhalation: A potential therapeutic strategy for geriatric inflammation and survival

Experimental gerontology

2023 Mechanism / Preclinical Saline / IV

2023 · Dumbuya — Hydrogen-rich saline regulates NLRP3 inflammasome activation in sepsis-associated encephalopathy rat model

International immunopharmacology

2023 Mechanism / Preclinical Inhalation

2023 · Liu — Hydrogen gas ameliorates acute alcoholic liver injury via anti-inflammatory and antioxidant effects and regulation of intestinal microbiota

International immunopharmacology

2023 Mechanism / Preclinical Drinking (HRW)

2023 · Zhu — Inorganic Nanosheet-Shielded Probiotics: A Self-Adaptable Oral Delivery System for Intestinal Disease Treatment

Nano letters

2023 · Wang — pH-Responsive Delivery of H₂ through Ammonia Borane-Loaded Hollow Polydopamine for Intervertebral Disc Degeneration Therapy

Oxidative medicine and cellular longevity

2023 Mechanism / Preclinical Inhalation

2023 · Iketani — H₂-induced transient upregulation of phospholipids with suppression of energy metabolism

Medical gas research

2023 · Zhu — Two-Dimensional Mg₂Si Nanosheet-Enabled Sustained Hydrogen Generation for Improved Repair and Regeneration of Deeply Burned Skin

Advanced healthcare materials

2022 Mechanism / Preclinical Bath / Topical Drinking (HRW)

2023 · Yang — Molecular Hydrogen Promotes Adipose-derived Stem Cell Myogenic Differentiation via Regulation of Mitochondria

Current stem cell research & therapy

2022 · Chen et al. — Photocatalytic Glucose Depletion and Hydrogen Generation for Diabetic Wound Healing

Nature communications

2022 · Yan et al. — Microbial Hydrogen „Manufactory” for Enhanced Gas Therapy and Self-Activated Immunotherapy via Reduced Immune Escape

Journal of nanobiotechnology

2022 · Geng et al. — Hydrogen Helps to Ameliorate Staphylococcus aureus-Induced Mastitis in Mice

International immunopharmacology

2022 Mechanism / Preclinical Saline / IV

2022 · Li — Local Treatment of Hydrogen-Rich Saline Promotes Wound Healing In Vivo by Inhibiting Oxidative Stress via Nrf-2/HO-1 Pathway

Oxidative medicine and cellular longevity

2022 Mechanism / Preclinical Inhalation Drinking (HRW)

2022 · Adzavon — Long-term and daily use of molecular hydrogen induces reprogramming of liver metabolism in rats by modulating NADP/NADPH redox pathways

Scientific reports

2022 Mechanism / Preclinical Drinking (HRW)

2022 · Mouzakis — Quantification of dissolved H₂ and continuous monitoring of hydrogen-rich water for haemodialysis applications: An experimental study

The International journal of artificial organs

2022 Mechanism / Preclinical Inhalation Saline / IV

2022 · Ge — Microbial hydrogen economy alleviates colitis by reprogramming colonocyte metabolism and reinforcing intestinal barrier

Gut microbes

2022 · Zhang — Metal-Organic-Framework-Based Hydrogen-Release Platform for Multieffective Helicobacter Pylori Targeting Therapy and Intestinal Flora Protective Capabilities

Advanced materials (Deerfield Beach, Fla.)