Oxidative stress

Oxidative stress is an imbalance between reactive oxygen species and the antioxidant systems that keep them in check. Here H₂ is studied as a possible selective radical scavenger; many papers measure markers such as d-ROMs or malondialdehyde.

Human studies on molecular hydrogen for Oxidative stress. This page collects the 356 studies catalogued in this area — 36 randomized trials, 56 pilot/observational studies and 115 reviews. Listed newest first.

2026 Review / Meta-analysis Inhalation

2026 · Seneff — The essential role of hydrogen gas recycling by gut microbes in reducing deuterium load in host mitochondria: is trimethylamine oxide a deuterium sensor?

Metabolomics : Official journal of the Metabolomic Society

2026 Review / Meta-analysis Unspecified

2026 · Dumbuya — The protective effects of molecular hydrogen in sepsis-associated encephalopathy: current status.

European journal of pharmacology

2026 Review / Meta-analysis Unspecified

2026 · Ostojic — Revisiting molecular hydrogen signaling in mitochondria: Is the Rieske protein the entry point or a downstream sentinel?

Redox biology

2026 Review / Meta-analysis Unspecified

2026 · Paparella — Medical Gases as Emerging Regulators of Paediatric Endocrine and Neurodevelopmental Pathways: A Mini-Review

Acta paediatrica (Oslo, Norway : 1992)

2026 Review / Meta-analysis Inhalation

2026 · Nguyen Puente — Emerging Clinical Applications for Molecular Hydrogen

Respiratory care

2026 Review / Meta-analysis Inhalation

2026 · Merigo — Gas Therapies for Neuro-Protection

Critical care clinics

2026 Review / Meta-analysis Inhalation Saline / IV Drinking (HRW)

2026 · Nguyen — Advances in hydrogen delivery strategies for therapeutic applications

Advanced drug delivery reviews

2026 Review / Meta-analysis Unspecified

2026 · Viana — Molecular hydrogen and kidney diseases: a scoping review based on scientometry and data analytics

Medical gas research

2025 Review / Meta-analysis Unspecified

2025 · Xie — Mechanisms and Protective Strategies for Astronaut Skin Injury in Deep Space Environments

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

2025 Review / Meta-analysis Unspecified

2025 · Kornieieva — Exploring the Potential of Molecular Hydrogen in Different Heart Failure Models: A Review

International journal of molecular sciences

2025 Review / Meta-analysis Unspecified

2025 · Zhu — Molecular mechanisms associated with effects of hydrogen molecule in liver diseases: the review of current evidence

European journal of medical research

2025 Review / Meta-analysis Unspecified

2025 · Li — Delivery of Molecular Hydrogen for Precision Immunomodulation: Mechanisms, Detection Methods, and Applications

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2025 Review / Meta-analysis Drinking (HRW)

2025 · Ye — Molecular hydrogen as a novel regulator of cellular pyroptosis: mechanistic insights and therapeutic implications

Molecular biology reports

2025 Review / Meta-analysis Unspecified

2025 · Brandi — Molecular hydrogen therapy: A „democratic” emerging strategy against aging and age-related diseases

Ageing research reviews

2025 Review / Meta-analysis Unspecified

2025 · Zajac — Molecular Hydrogen in the Treatment of Respiratory Diseases

International journal of molecular sciences

2025 Review / Meta-analysis Drinking (HRW)

2025 · Bjørklund — Advanced Glycation End Products and Skin Autoimmune Disorders: Pathogenic Insights into Vitiligo, Bullous Pemphigoid, and Type 1 Diabetes Mellitus

Current medicinal chemistry

2025 Review / Meta-analysis Drinking (HRW)

2025 · Bilski — Antioxidant Therapies as Emerging Adjuncts in Rheumatoid Arthritis: Targeting Oxidative Stress to Enhance Treatment Outcomes

International journal of molecular sciences

2025 Review / Meta-analysis Unspecified

2025 · Sahu — Activation, interaction and intimation of Nrf2 pathway and their mutational studies causing Nrf2 associated cancer

Biochimica et biophysica acta. Molecular basis of disease

2025 Review / Meta-analysis Unspecified

2025 · Ying — Molecular hydrogen: Mechanism against oxidative stress and application in periodontitis: A review

Medicine

2025 Review / Meta-analysis Drinking (HRW)

2025 · Alaqel — Aging, vascular dysfunction, and the blood-brain barrier: unveiling the pathophysiology of stroke in older adults

Biogerontology

2025 Review / Meta-analysis Unspecified

2025 · Neykhonji — Exploring the Potential of H₂ Therapy in Reducing Surgical Complications: A Review on Anti-inflammatory, Antioxidant, and Anti-fibrotic Mechanisms

Current pharmaceutical design

2025 Review / Meta-analysis Drinking (HRW)

2025 · Meng — Oral Administration of Hydrogen-rich Water: Biomedical Activities, Potential Mechanisms, and Clinical Applications

Current pharmaceutical design

2025 Review / Meta-analysis Inhalation

2025 · Li — Application Trends of Hydrogen-generating Nanomaterials for the Treatment of ROS-related Diseases

Biomaterials science

2025 Review / Meta-analysis Unspecified

2025 · Todorović — Hydrogen as an Innovative Nootropic in Health and Disease

Nutrition and health

2024 Review / Meta-analysis Drinking (HRW)

2024 · Dhillon — Hydrogen Water: Extra Healthy or a Hoax?—A Systematic Review

International Journal of Molecular Sciences

2024 Review / Meta-analysis Unspecified

2024 · Slezák — New Possibilities of the Prevention and Treatment of Cardiovascular Pathologies: The Potential of Molecular Hydrogen in the Reduction of Oxidative Stress

Physiological research

2024 Review / Meta-analysis Drinking (HRW)

2024 · Glevicka — Perspective Targeted Diagnosis and Therapy of Mitochondrial Bioenergetics Across Different Diagnoses

Bratislavske lekarske listy

2024 Review / Meta-analysis Inhalation

2024 · Xu — The Landscape of Smart Biomaterial-Based Hydrogen Therapy

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2024 Review / Meta-analysis Unspecified

2024 · Wu — Evolution of Therapeutic Strategy Based on Oxidant-Antioxidant Balance for Fuchs Endothelial Corneal Dystrophy

The ocular surface

2024 Review / Meta-analysis Unspecified

2024 · Kura — The Protective Role of Molecular Hydrogen in Ischemia/Reperfusion Injury

International journal of molecular sciences

2024 Review / Meta-analysis Unspecified

2024 · Zheng — Potential Role of Molecular Hydrogen Therapy on Oxidative Stress and Redox Signaling in Chronic Kidney Disease

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024 Review / Meta-analysis Unspecified

2024 · Hu — The Molecular Biological Mechanism of Hydrogen Therapy and Its Application in Spinal Cord Injury

Drug design, development and therapy

2024 Review / Meta-analysis Unspecified

2024 · Khiji — The Therapeutic Application of Hydrogen in Cancer: The Potential and Challenges

Current pharmaceutical design

2024 Review / Meta-analysis Unspecified

2024 · Chen — The Role of Hydrogen in the Prevention and Treatment of Coronary Atherosclerotic Heart Disease

European journal of pharmacology

2023 Review / Meta-analysis Unspecified

2023 · Mohd Noor — A Systematic Review of Molecular Hydrogen Therapy in Cancer Management

Asian Pacific Journal of Cancer Prevention

2023 Review / Meta-analysis Unspecified

2023 · Artamonov — Molecular Hydrogen: From Molecular Effects to Stem Cells Management and Tissue Regeneration

Antioxidants (Basel)

2023 Review / Meta-analysis Inhalation Saline / IV Drinking (HRW)

2023 · Kuo — Molecular Hydrogen: Emerging Treatment for Stroke Management

Chemical Research in Toxicology

2023 Review / Meta-analysis Inhalation

2023 · Johnsen et al. — Molecular Hydrogen Therapy — A Review on Clinical Studies and Outcomes

Molecules (Basel, Switzerland)

2023 Review / Meta-analysis Unspecified

2023 · He et al. — The Role of Hydrogen Therapy in Alzheimer's Disease Management: Insights into Mechanisms, Administration Routes, and Future Challenges

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Review / Meta-analysis Inhalation Saline / IV Bath / Topical Drinking (HRW)

2023 · Saengsin et al. — Hydrogen Therapy as a Potential Therapeutic Intervention in Heart Disease: From the Past Evidence to Future Application

Cellular and molecular life sciences : CMLS

2023 Review / Meta-analysis Unspecified

2023 · Ichikawa et al. — The Overlooked Benefits of Hydrogen-Producing Bacteria

Medical gas research

2023 Review / Meta-analysis Unspecified

2023 · Wu et al. — Molecular Hydrogen: An Emerging Therapeutic Medical Gas for Brain Disorders

Molecular neurobiology

2023 Review / Meta-analysis Inhalation Drinking (HRW)

2023 · Li — Trend of research on the medical use of molecular hydrogen: a bibliometric analysis

Medical gas research

2022 Review / Meta-analysis Drinking (HRW)

2022 · LeBaron — Electrolyzed-Reduced Water: Review I. Molecular Hydrogen Is the Exclusive Agent Responsible for the Therapeutic Effects

International Journal of Molecular Sciences

2022 Review / Meta-analysis Drinking (HRW)

2022 · Lippi — Impact of nutraceuticals and dietary supplements on mitochondria modifications in healthy aging: a systematic review of randomized controlled trials

Aging clinical and experimental research

2022 Review / Meta-analysis Unspecified

2022 · Fu — Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases

Oxidative medicine and cellular longevity

2022 Review / Meta-analysis Unspecified

2022 · Ahmad et al. — Narrative on Hydrogen Therapy and its Clinical Applications: Safety and Efficacy

Current pharmaceutical design

2022 Review / Meta-analysis Unspecified

2022 · Fu — Molecular hydrogen is a promising therapeutic agent for pulmonary disease

Journal of Zhejiang University. Science. B

2021 Review / Meta-analysis Unspecified

2021 · Qi — Perspective of Molecular Hydrogen in the Treatment of Sepsis

Current Pharmaceutical Design

2021 Review / Meta-analysis Inhalation Drinking (HRW)

2021 · Noda — Neuroprotective and Preventative Effects of Molecular Hydrogen

Current Pharmaceutical Design

2021 Review / Meta-analysis Unspecified

2021 · Alwazeer — Combating Oxidative Stress and Inflammation in COVID-19 by Molecular Hydrogen Therapy: Mechanisms and Perspectives.

Oxidative medicine and cellular longevity

2021 Review / Meta-analysis Unspecified

2021 · Hirano — Molecular Hydrogen as a Novel Antitumor Agent: Possible Mechanisms Underlying Gene Expression.

International journal of molecular sciences

2021 Review / Meta-analysis Unspecified

2021 · Yamamoto — Molecular Hydrogen as a Novel Protective Agent against Pre-Symptomatic Diseases.

International journal of molecular sciences

2021 Review / Meta-analysis Unspecified

2021 · Schönfeld — How the brain fights fatty acids' toxicity.

Neurochemistry international

2021 Review / Meta-analysis Unspecified

2021 · Hirano — Molecular Hydrogen as a Potential Clinically Applicable Radioprotective Agent.

International journal of molecular sciences

2021 Review / Meta-analysis Inhalation Saline / IV Bath / Topical Drinking (HRW)

2021 · Quan — Protective effects of molecular hydrogen on lung injury from lung transplantation.

Experimental biology and medicine (Maywood, N.J.)

2021 Review / Meta-analysis Unspecified

2021 · Hirano — Potential Therapeutic Applications of Hydrogen in Chronic Inflammatory Diseases: Possible Inhibiting Role on Mitochondrial Stress.

International journal of molecular sciences

2021 Review / Meta-analysis Unspecified

2021 · Shi et al. — Hydrogen treatment: a novel option in liver diseases.

Clinical medicine (London, England)

2021 Review / Meta-analysis Inhalation

2021 · Chen et al. — Chemical and Biochemical Aspects of Molecular Hydrogen in Treating Kawasaki Disease and COVID-19.

Chemical research in toxicology

2021 Review / Meta-analysis Inhalation Bath / Topical

2021 · Zhang et al. — Hydrogen Gas: A Novel Type of Antioxidant in Modulating Sexual Organs Homeostasis.

Oxidative medicine and cellular longevity

2021 Review / Meta-analysis Inhalation Saline / IV

2021 · Sano et al. — Hydrogen Gas Therapy: From Preclinical Studies to Clinical Trials.

Current pharmaceutical design

2021 Review / Meta-analysis Unspecified

2021 · Domoki — Hydrogen-induced Neuroprotection in Neonatal Hypoxic-ischemic Encephalopathy.

Current pharmaceutical design

2021 Review / Meta-analysis Unspecified

2021 · Nogueira et al. — Recent Advances in Molecular Hydrogen Research Reducing Exercise-Induced Oxidative Stress and Inflammation.

Current pharmaceutical design

2021 Review / Meta-analysis Unspecified

2021 · Li et al. — Recent advances in studies of molecular hydrogen in the treatment of pancreatitis.

Life sciences

2021 Review / Meta-analysis Unspecified

2021 · Bajgai et al. — Role of Molecular Hydrogen in Skin Diseases and its Impact in Beauty.

Current pharmaceutical design

2021 Review / Meta-analysis Unspecified

2021 · Ohta — Direct Targets and Subsequent Pathways for Molecular Hydrogen to Exert Multiple Functions: Focusing on Interventions in Radical Reactions

Current pharmaceutical design

2021 Review / Meta-analysis Inhalation

2021 · Htun et al. — Hydrogen and Therapeutic Gases for Neonatal Hypoxic-Ischemic Encephalopathy: Potential Neuroprotective Adjuncts in Translational Research

Pediatric research

2021 Review / Meta-analysis Unspecified

2021 · Lucas — Molecular hydrogen (H₂) as a potential treatment for acute and chronic fatigue

Archiv der Pharmazie

2021 Review / Meta-analysis Inhalation Saline / IV Drinking (HRW)

2021 · Ostojic — Hydrogen Gas as an Exotic Performance-Enhancing Agent: Challenges and Opportunities

Current pharmaceutical design

2021 Review / Meta-analysis Unspecified

2021 · Slezak et al. — Oxidative Stress and Pathways of Molecular Hydrogen Effects in Medicine

Current pharmaceutical design

2020 Review / Meta-analysis Unspecified

2020 · Hu — Molecular hydrogen: A potential radioprotective agent

Biomedicine & Pharmacotherapy

2020 Review / Meta-analysis Unspecified

2020 · Wang — Prospects of molecular hydrogen in perioperative neuroprotection from basic research to clinical application

Current Opinion in Anaesthesiology

2020 Review / Meta-analysis Inhalation

2020 · Hirano et al. — A „philosophical molecule,” hydrogen may overcome senescence and intractable diseases

Medical gas research

2020 Review / Meta-analysis Inhalation Bath / Topical Drinking (HRW)

2020 · Kawamura et al. — Application of Molecular Hydrogen as a Novel Antioxidant in Sports Science

Oxidative medicine and cellular longevity

2019 Review / Meta-analysis Inhalation

2019 · Zhou — Micro/Nanomaterials-Augmented Hydrogen Therapy

Advanced Healthcare Materials

2019 Review / Meta-analysis Inhalation

2019 · Qian — Medical Application of Hydrogen in Hematological Diseases.

Oxidative medicine and cellular longevity

2019 Review / Meta-analysis Unspecified

2019 · Morris — Myalgic encephalomyelitis/chronic fatigue syndrome: From pathophysiological insights to novel therapeutic opportunities.

Pharmacological research

2019 Review / Meta-analysis Inhalation Saline / IV Drinking (HRW)

2019 · LeBaron et al. — A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress.

Molecules (Basel, Switzerland)

2019 Review / Meta-analysis Drinking (HRW)

2019 · Noda et al. — Circulating messenger for neuroprotection induced by molecular hydrogen.

Canadian journal of physiology and pharmacology

2019 Review / Meta-analysis Drinking (HRW)

2019 · Ishibashi — Therapeutic Efficacy of Molecular Hydrogen: A New Mechanistic Insight.

Current pharmaceutical design

2019 Review / Meta-analysis Inhalation Drinking (HRW)

2019 · LeBaron et al. — Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes.

Canadian journal of physiology and pharmacology

2019 Review / Meta-analysis Unspecified

2019 · Cejka et al. — The preventive and therapeutic effects of molecular hydrogen in ocular diseases and injuries where oxidative stress is involved.

Free radical research

2019 Review / Meta-analysis Unspecified

2019 · Kura et al. — Molecular hydrogen: potential in mitigating oxidative-stress-induced radiation injury.

Canadian journal of physiology and pharmacology

2019 Review / Meta-analysis Inhalation

2019 · Li et al. — Hydrogen as a complementary therapy against ischemic stroke: A review of the evidence.

Journal of the neurological sciences

2019 Review / Meta-analysis Saline / IV

2019 · Wang et al. — Neonatal hypoxic-ischemic encephalopathy: emerging therapeutic strategies based on pathophysiologic phases of the injury.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2019 Review / Meta-analysis Unspecified

2019 · Tao et al. — Molecular hydrogen: current knowledge on mechanism in alleviating free radical damage and diseases.

Acta biochimica et biophysica Sinica

2018 Review / Meta-analysis Saline / IV Drinking (HRW)

2018 · Chen — Research progress of hydrogen-rich saline for eye diseases.

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology

2018 Review / Meta-analysis Unspecified

2018 · Morris — The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders

Sleep medicine reviews

2017 Review / Meta-analysis Inhalation Saline / IV Drinking (HRW)

2017 · Iketani — Molecular Hydrogen as a Neuroprotective Agent

Current Neuropharmacology

2016 Review / Meta-analysis Saline / IV Drinking (HRW)

2016 · Iida — The Clinical Application of Hydrogen as a Medical Treatment

Acta medica Okayama

2016 Review / Meta-analysis Unspecified

2016 · Slezák — Preventive and Therapeutic Application of Molecular Hydrogen in Situations with Excessive Production of Free Radicals

Physiological research

2016 Review / Meta-analysis Unspecified

2016 · Zheng — Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis

Oxidative medicine and cellular longevity

2015 Review / Meta-analysis Inhalation Saline / IV Bath / Topical Drinking (HRW)

2015 · Ohta — Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications.

Methods in enzymology

2015 Review / Meta-analysis Unspecified

2015 · Ostojic — Molecular hydrogen in sports medicine: new therapeutic perspectives.

International journal of sports medicine

2014 Review / Meta-analysis Inhalation

2014 · Xie et al. — Hydrogen gas presents a promising therapeutic strategy for sepsis.

BioMed research international

2014 Review / Meta-analysis Inhalation Saline / IV Bath / Topical Drinking (HRW)

2014 · Ohta — Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine.

Pharmacology & therapeutics

2014 Review / Meta-analysis Saline / IV

2014 · Fernández-Gajardo et al. — Novel therapeutic strategies for traumatic brain injury: acute antioxidant reinforcement.

CNS drugs

2013 Review / Meta-analysis Unspecified

2013 · Wang — Introspection of oxidant/antioxidant imbalance in the inner ear

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery

2013 Review / Meta-analysis Saline / IV Drinking (HRW)

2013 · Qian — Hydrogen as a new class of radioprotective agent

International journal of biological sciences

2013 Review / Meta-analysis Drinking (HRW)

2013 · Takaki — Multiple hits, including oxidative stress, as pathogenesis and treatment target in non-alcoholic steatohepatitis (NASH)

International journal of molecular sciences

2013 Review / Meta-analysis Unspecified

2013 · Schönfeld — Why does brain metabolism not favor burning of fatty acids to provide energy? Reflections on disadvantages of the use of free fatty acids as fuel for brain

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

2013 Review / Meta-analysis Unspecified

2013 · Ishibashi — Molecular hydrogen: new antioxidant and anti-inflammatory therapy for rheumatoid arthritis and related diseases

Current pharmaceutical design

2013 Review / Meta-analysis Inhalation

2013 · Lucas — Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway

Molecular neurobiology

2012 Review / Meta-analysis Drinking (HRW)

2012 · Chuai — Molecular hydrogen and radiation protection

Free Radical Research

2012 Review / Meta-analysis Drinking (HRW)

2012 · Ohno et al. — Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases.

Oxidative medicine and cellular longevity

2012 Review / Meta-analysis Inhalation

2012 · Carbonero et al. — Contributions of the microbial hydrogen economy to colonic homeostasis.

Nature reviews. Gastroenterology & hepatology

2012 Review / Meta-analysis Inhalation Saline / IV Bath / Topical Drinking (HRW)

2012 · Ohta — Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases.

Biochimica et biophysica acta

2012 Review / Meta-analysis Inhalation

2012 · Nie et al. — Hydrogenase: the next antibiotic target?

Clinical science (London, England : 1979)

2011 Review / Meta-analysis Inhalation Saline / IV Bath / Topical Drinking (HRW)

2011 · Ohta — Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications.

Current pharmaceutical design

2011 Review / Meta-analysis Unspecified

2011 · Noda et al. — The principle and the potential approach to ROS-dependent cytotoxicity by non-pharmaceutical therapies: optimal use of medical gases with antioxidant properties.

Current pharmaceutical design

2011 Review / Meta-analysis Inhalation

2011 · Zheng et al. — Hydrogen resuscitation, a new cytoprotective approach.

Clinical and experimental pharmacology & physiology

2011 Review / Meta-analysis Drinking (HRW)

2011 · Acuña Castroviejo — Melatonin-Mitochondria Interplay in Health and Disease

Current topics in medicinal chemistry

2010 Review / Meta-analysis Unspecified

2010 · Hong — Research Advances on Hydrogen Therapy in Nervous System Diseases

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences

2010 Review / Meta-analysis Inhalation

2010 · Shen — Hydrogen as a novel and effective treatment of acute carbon monoxide poisoning.

Medical hypotheses

2002 Review / Meta-analysis Drinking (HRW)

2002 · Acuña Castroviejo et al. — Melatonin, mitochondrial homeostasis and mitochondrial-related diseases

Current topics in medicinal chemistry

2026 RCT Human H₂ therapy Drinking (HRW)

2026 · Stolecka-Warzecha — Redox Water Consumption Attenuates Exercise-Induced Inflammation and Oxidative Stress in Physically Active Adults: A Randomized Controlled Trial

Nutrients

2026 RCT Human H₂ therapy Drinking (HRW)

2026 · Kuang — Exploratory Evaluation of Hydrogen-Rich Water Therapy for Keloid Management: A Double-Blinded Randomized Pilot Trial

Aesthetic Plastic Surgery

2025 RCT Human H₂ therapy Inhalation Bath / Topical

2025 · Grepl — Molecular hydrogen inhalation modulates resting metabolism in healthy females: findings from a randomized, double-blind, placebo-controlled crossover study

Medical Gas Research

2025 RCT Human H₂ therapy Tablets Drinking (HRW)

2025 · Ogannisyan — Hydrogen-Rich Water Decreases Muscle Damage and Improves Power Endurance in Elite Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial

Journal of Lifestyle Medicine

2025 RCT Human H₂ therapy Drinking (HRW)

2025 · Kuzmanovic — The effects of drinking hydrogen-rich water for six weeks on exercise-related biomarkers in exercise-naïve men and women over 50 years following resistance training program: a randomized controlled pilot trial

Research in Sports Medicine

2025 RCT Human H₂ therapy Drinking (HRW)

2025 · Khlifi — Pre-Exercise Ingestion of Hydrogen-Rich Cold Water Enhances Endurance Performance and Lactate Response in Heat

Medicina (Kaunas)

2025 RCT Human H₂ therapy Drinking (HRW)

2025 · Zhang — Hydrogen-rich water supplementation attenuates oxidative stress and inflammation in chronic high-altitude disease patients: A double-blind randomized placebo-controlled study

Food Research International

2024 RCT Human H₂ therapy Drinking (HRW)

2024 · Aker — The effect of hydrogen-rich water consumption on premenstrual symptoms and quality of life: a randomized controlled trial

BMC Women's Health

2024 RCT Human H₂ therapy Inhalation

2024 · Chair — The impact of hydrogen inhalation therapy on blood reactive oxygen species levels: A randomized controlled study

Free Radical Biology & Medicine

2024 RCT Human H₂ therapy Inhalation Drinking (HRW)

2024 · Zhao — Hydrogen gas inhalation prior to high-intensity training reduces attenuation of nitric oxide bioavailability in male rugby players

PeerJ

2024 RCT Human H₂ therapy Inhalation

2024 · Dong — Inhalation of Hydrogen-Rich Gas before Acute Exercise Alleviates Exercise Fatigue: A Randomized Crossover Study

International journal of sports medicine

2023 RCT Human H₂ therapy Inhalation

2023 · Deryugina — Molecular hydrogen exposure improves functional state of red blood cells in the early postoperative period: a randomized clinical study

Medical Gas Research

2023 RCT Human H₂ therapy Drinking (HRW)

2023 · Najmanová — Effect of Acute Hydrogen-Rich Water Intake on Intraocular Pressure in Healthy Subjects

Ceska a slovenska oftalmologie

2022 RCT Human H₂ therapy Drinking (HRW)

2022 · Botek — Hydrogen Rich Water Consumption Positively Affects Muscle Performance, Lactate Response, and Alleviates Delayed Onset of Muscle Soreness After Resistance Training

Journal of Strength and Conditioning Research

2022 RCT Human H₂ therapy Inhalation

2022 · Botek — Molecular Hydrogen Positively Affects Physical and Respiratory Function in Acute Post-COVID-19 Patients: A New Perspective in Rehabilitation

International Journal of Environmental Research and Public Health

2022 RCT Human H₂ therapy Drinking (HRW)

2022 · Botek — Molecular Hydrogen Mitigates Performance Decrement during Repeated Sprints in Professional Soccer Players

Nutrients

2022 RCT Human H₂ therapy Inhalation

2022 · Tao — A randomized, placebo-controlled clinical trial of hydrogen/oxygen inhalation for non-alcoholic fatty liver disease

Journal of Cellular and Molecular Medicine

2022 RCT Human H₂ therapy Drinking (HRW)

2022 · Alharbi — The Acute Effects of a Single Dose of Molecular Hydrogen Supplements on Responses to Ergogenic Adjustments during High-Intensity Intermittent Exercise in Humans

Nutrients

2022 RCT

2022 · Eda — Effects of Intestinal Bacterial Hydrogen Gas Production on Muscle Recovery following Intense Exercise in Adult Men: A Pilot Study

Nutrients

2021 RCT Human H₂ therapy Bath / Topical Drinking (HRW)

2021 · Javorac — Hydrotherapy with hydrogen-rich water compared with RICE protocol following acute ankle sprain in professional athletes: a randomized non-inferiority pilot trial

Research in Sports Medicine

2021 RCT Human H₂ therapy Drinking (HRW)

2021 · Alharbi — Application of Molecular Hydrogen as an Antioxidant in Responses to Ventilatory and Ergogenic Adjustments during Incremental Exercise in Humans

Nutrients

2021 RCT Human H₂ therapy Inhalation

2021 · Yoritaka — Randomized double-blind placebo-controlled trial of hydrogen inhalation for Parkinson's disease: a pilot study

Neurological Sciences

2021 RCT Human H₂ therapy Drinking (HRW)

2021 · Zanini — The effects of 6-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in older adults aged 70 years and over: A randomized controlled pilot trial

Experimental Gerontology

2020 RCT Human H₂ therapy Drinking (HRW)

2020 · Ishibashi — Peripheral endothelial function can be improved by daily consumption of water containing over 7 ppm of dissolved hydrogen: A randomized controlled trial

PLoS One

2020 RCT Human H₂ therapy Drinking (HRW)

2020 · Sim — Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial

Scientific Reports

2020 RCT Human H₂ therapy Inhalation Bath / Topical

2020 · Shibayama — Impact of hydrogen-rich gas mixture inhalation through nasal cannula during post-exercise recovery period on subsequent oxidative stress, muscle damage, and exercise performances in men

Medical Gas Research

2020 RCT Human H₂ therapy Drinking (HRW)

2020 · Dobashi et al. — Hydrogen-rich water suppresses the reduction in blood total antioxidant capacity induced by 3 consecutive days of severe exercise in physically active males.

Medical gas research

2019 RCT Human H₂ therapy Drinking (HRW)

2019 · Mikami — Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study

Canadian Journal of Physiology and Pharmacology

2018 RCT Human H₂ therapy Drinking (HRW)

2018 · Nishimaki — Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment

Current Alzheimer research

2017 RCT Human H₂ therapy Inhalation Saline / IV

2017 · Ono et al. — Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

2016 RCT Human H₂ therapy Inhalation

2016 · Gong et al. — Protective effect of hydrogen on the lung of sanitation workers exposed to haze.

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases

2014 RCT Human H₂ therapy Drinking (HRW)

2014 · Sakai et al. — Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function.

Vascular health and risk management

2014 RCT Human H₂ therapy Tablets Bath / Topical Drinking (HRW)

2014 · Ostojic et al. — Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries.

Postgraduate medicine

2014 RCT Human H₂ therapy Saline / IV

2014 · Ishibashi et al. — Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study.

International immunopharmacology

2013 RCT Human H₂ therapy Drinking (HRW)

2013 · Xia et al. — Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B.

Clinical and translational science

2013 RCT Human H₂ therapy Drinking (HRW)

2013 · Yoritaka et al. — Pilot study of H₂ therapy in Parkinson's disease: a randomized double-blind placebo-controlled trial.

Movement disorders : official journal of the Movement Disorder Society

2026 Pilot / Observational Human H₂ therapy Inhalation Bath / Topical

2026 · Pozdnyakova — The combined use of inhaled nitric oxide and molecular hydrogen in patients with post-COVID-19 syndrome

Terapevticheskii arkhiv

2026 Pilot / Observational Human H₂ therapy Drinking (HRW)

2026 · Li — Adjunctive Molecular Hydrogen Capsule Therapy in Empyema Complicated by Chronic Inflammatory Demyelinating Polyneuropathy: A Case Report

In vivo (Athens, Greece)

2026 Pilot / Observational Human H₂ therapy Saline / IV

2026 · Xu et al. — Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via Promoting Mitophagy

Journal of diabetes

2026 Pilot / Observational Human H₂ therapy Saline / IV Drinking (HRW)

2026 · Lin et al. — Adjunctive Molecular Hydrogen Therapy Modulates T Cell Markers and Reduces Anti-Ro Antibody in Refractory Oral Ulcers of Behçet's Disease and Sjögren's Syndrome: A Case Report

In vivo (Athens, Greece)

2026 Pilot / Observational Human H₂ therapy Inhalation Bath / Topical

2025 · Moriya et al. — Hydrogen Inhalation Is Associated With a Transient Rightward Shift in Prefrontal Oxyhemoglobin Asymmetry and Autonomic Modulation

Scientific reports

2026 Pilot / Observational Human H₂ therapy Drinking (HRW)

2026 · Tsai et al. — Rhupus Syndrome With Multiple Drug Intolerances Managed by Reduced-dose Rituximab and Adjunctive Molecular Hydrogen Therapy: A Case Report

In vivo (Athens, Greece)

2026 Pilot / Observational Human H₂ therapy Unspecified

2026 · Liu et al. — Adjuvant Molecular Hydrogen Therapy in SLE-associated Pulmonary Arterial Hypertension: A Case Report on Immunomodulatory Effects on Regulatory and Effector Lymphocytes

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Kotenko et al. — Biochemical Markers of Stress in Medical Workers With Occupational Burnout Syndrome and Their Dynamics Under Physiotherapeutic Factors

Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury

2025 Pilot / Observational Human H₂ therapy Drinking (HRW)

2025 · Ren et al. — A Case Report of Adjuvant Molecular Hydrogen Therapy in Refractory Rheumatoid Arthritis With Atlantoaxial Subluxation

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Liu et al. — Dynamic Immunomodulation by Hydrogen Capsule Therapy in SLE-associated Pulmonary Arterial Hypertension: A Case Report

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Drinking (HRW)

2025 · Tu et al. — Immunomodulatory Effects of Molecular Hydrogen Therapy in Systemic Lupus Erythematosus With Pericarditis and Pleuritis: A Case Report

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Drinking (HRW)

2025 · Wong et al. — Nano-Bubble Hydrogen Water in Wet-Wrap Dressing Improves the Severity of Pediatric Patients With Atopic Dermatitis

Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners

2025 Pilot / Observational Human H₂ therapy Drinking (HRW)

2025 · Hruby et al. — Hydrogen-Rich Water Consumption for Acute and Residual Fatigue After Simulated Football Matches: Protocol for a Randomized, Double-Blinded, Placebo-Controlled, Parallel Trial

JMIR research protocols

2025 Pilot / Observational Human H₂ therapy Drinking (HRW)

2025 · Lui et al. — Predicting Therapeutic Response to Molecular Hydrogen in Autoimmune Diseases via Immunophenotyping

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

2025 Pilot / Observational Human H₂ therapy Drinking (HRW)

2025 · Tu et al. — Molecular Hydrogen Therapy in Rheumatoid Arthritis: A Case Report on the Amelioration of Methotrexate-induced Myelosuppression and Immune Modulation

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Tsai et al. — Molecular Hydrogen as an Adjuvant Therapy in Comorbid Sjögren's Syndrome, SLE, and ILD: A Case Report on Immune Modulation and Fatigue Reduction

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Lin et al. — Molecular Hydrogen Capsule Therapy for Primary Biliary Cholangitis With Elevated IgG4: A Case Report on Immune Marker Normalization

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Hsu et al. — Molecular Hydrogen Therapy Enhances Immune Markers in Treg, Plasma, Tr1 Cells, and KLRG1 Expression on Tc Cells: A Case of Acute SDH With Midline Shift and Uncal Herniation Post-decompressive Craniectomy

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Lin et al. — Molecular Hydrogen as an Adjuvant Therapy in Severe Lupus Serositis With Heart Failure: A Case Report on Immune Modulation and Fatigue Reduction

In vivo (Athens, Greece)

2025 Pilot / Observational Human H₂ therapy Saline / IV

2025 · Kuang et al. — Hydrogen-Rich Saline Combined With Vacuum Sealing Drainage Promotes Wound Healing by Altering Biotin Metabolism

Journal of cellular and molecular medicine

2025 Pilot / Observational Human H₂ therapy Unspecified

2025 · Lin et al. — Molecular Hydrogen as a Potential Adjunctive Therapy to Improve Renal Function and Reduce Fatigue in an Elderly Patient With Chronic Comorbidities: A Case Report

In vivo (Athens, Greece)

2024 Pilot / Observational Human H₂ therapy Inhalation

2024 · Pozdnyakova — Rehabilitation program of post-COVID-19 syndrome with the use of nitric oxide and molecular hydrogen

Terapevticheskii Arkhiv

2024 Pilot / Observational Human H₂ therapy Inhalation Bath / Topical

2024 · Salomez-Ihl — H2 inhalation therapy in patients with moderate COVID-19 (H2COVID): a prospective ascending-dose phase I clinical trial

Antimicrobial Agents and Chemotherapy

2024 Pilot / Observational Human H₂ therapy Drinking (HRW)

2024 · Lu — Using oral molecular hydrogen supplements to combat microinflammation in humans: a pilot observational study

International Journal of Medical Sciences

2024 Pilot / Observational Human H₂ therapy Inhalation Saline / IV

2024 · Mu — Hydrogen regulated pyroptosis through NLRP3-GSDMD pathway to improve airway mucosal oxidative stress injury induced by endotracheal tube cuff compression.

Free radical biology & medicine

2024 Pilot / Observational Human H₂ therapy Unspecified

2024 · Lui — Molecular Hydrogen as a Promising Therapy Could Be Linked With Increased Resting Treg Cells or Decreased Fas+ T Cell Subsets in a IgG4-PF-ILD Patient: A Case Report.

In vivo (Athens, Greece)

2024 Pilot / Observational Human H₂ therapy Inhalation

2024 · Liu — The Benefit of Hydrogen Gas as an Adjunctive Therapy for Chronic Obstructive Pulmonary Disease.

Medicina (Kaunas, Lithuania)

2023 Pilot / Observational Human H₂ therapy Tablets Drinking (HRW)

2023 · Sumbalová — The Effect of Adjuvant Therapy with Molecular Hydrogen on Endogenous Coenzyme Q10 Levels and Platelet Mitochondrial Bioenergetics in Patients with Non-Alcoholic Fatty Liver Disease.

International journal of molecular sciences

2022 Pilot / Observational Human H₂ therapy Inhalation

2022 · Zhao — Effectiveness and safety of hydrogen inhalation as an adjunct treatment in Chinese type 2 diabetes patients: A retrospective, observational, double-arm, real-life clinical study

Frontiers in Endocrinology

2022 Pilot / Observational Human H₂ therapy Inhalation

2022 · Deryugina — Dynamics of Metabolic and Oxidative Parameters of Erythrocytes during Treatment of Chronic Heart Failure with Molecular Hydrogen.

Bulletin of experimental biology and medicine

2022 Pilot / Observational Human H₂ therapy Drinking (HRW)

2022 · Dong — Short-Term Consumption of Hydrogen-Rich Water Enhances Power Performance and Heart Rate Recovery in Dragon Boat Athletes

International journal of environmental research and public health

2022 Pilot / Observational Human H₂ therapy Bath / Topical

2022 · Tanaka — Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity and inflammation levels in human serum

Medical gas research

2021 Pilot / Observational Human H₂ therapy Drinking (HRW)

2021 · Hong — Effects of concomitant use of hydrogen water and photobiomodulation on Parkinson disease: A pilot study

Medicine

2021 Pilot / Observational Human H₂ therapy Drinking (HRW)

2021 · Kubota — Randomized, crossover clinical efficacy trial in humans and mice on tear secretion promotion and lacrimal gland protection by molecular hydrogen

Scientific Reports

2021 Pilot / Observational Human H₂ therapy Inhalation

2021 · Hirano — Protective effects of hydrogen gas inhalation on radiation-induced bone marrow damage in cancer patients: a retrospective observational study

Medical Gas Research

2021 Pilot / Observational Human H₂ therapy Inhalation

2021 · Kaibori — Effect of hydrogen gas inhalation on patient QOL after hepatectomy: protocol for a randomised controlled trial

Trials

2021 Pilot / Observational Human H₂ therapy Inhalation

2021 · Danilova — Application of Molecular Hydrogen in Heart Surgery under Cardiopulmonary Bypass

Sovremennye tekhnologii v meditsine

2021 Pilot / Observational Human H₂ therapy Drinking (HRW)

2021 · Si — Effects of hydrogen as adjuvant treatment for unstable angina

Experimental biology and medicine (Maywood, N.J.)

2020 Pilot / Observational Human H₂ therapy Drinking (HRW)

2020 · Qian — Hydrogen in Patients With Corticosteroid-Refractory/Dependent Chronic Graft-Versus-Host-Disease: A Single-Arm, Multicenter, Open-Label, Phase 2 Trial

Frontiers in Immunology

2020 Pilot / Observational Human H₂ therapy Drinking (HRW)

2020 · Asada et al. — Effects of hydrogen-rich water prepared by alternating-current-electrolysis on antioxidant activity, DNA oxidative injuries, and diabetes-related markers.

Medical gas research

2020 Pilot / Observational Human H₂ therapy Inhalation

2020 · Hori et al. — Inhalation of molecular hydrogen increases breath acetone excretion during submaximal exercise: a randomized, single-blinded, placebo-controlled study.

Medical gas research

2020 Pilot / Observational Human H₂ therapy Inhalation

2020 · Wang et al. — Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients.

QJM : monthly journal of the Association of Physicians

2019 Pilot / Observational Human H₂ therapy Inhalation

2019 · Chen et al. — „Real world survey“ of hydrogen-controlled cancer: a follow-up report of 82 advanced cancer patients.

Medical gas research

2018 Pilot / Observational Human H₂ therapy Bath / Topical Drinking (HRW)

2018 · Zhu — Positive Effects of Hydrogen-Water Bathing in Patients of Psoriasis and Parapsoriasis en Plaques

Scientific reports

2018 Pilot / Observational Human H₂ therapy Unspecified

2018 · Franceschelli — Modulation of the Oxidative Plasmatic State in Gastroesophageal Reflux Disease with the Addition of Hydrogen-Rich Water: A New Biological Vision

Journal of cellular and molecular medicine

2017 Pilot / Observational Human H₂ therapy Unspecified

2017 · Nakayama et al. — Possible clinical effects of molecular hydrogen (H₂) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation.

PloS one

2017 Pilot / Observational Human H₂ therapy Saline / IV

2017 · Qian et al. — Therapeutic effects of hydrogen on chronic graft-versus-host disease.

Journal of cellular and molecular medicine

2015 Pilot / Observational

2015 · Tamasawa et al. — Hydrogen gas production is associated with reduced interleukin-1β mRNA in peripheral blood after a single dose of acarbose in Japanese type 2 diabetic patients.

European journal of pharmacology

2015 Pilot / Observational Human H₂ therapy Inhalation Saline / IV Drinking (HRW)

2015 · Ishibashi et al. — Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases.

Molecular medicine reports

2013 Pilot / Observational Human H₂ therapy Inhalation Drinking (HRW)

2013 · Shimouchi et al. — Molecular hydrogen consumption in the human body during the inhalation of hydrogen gas.

Advances in experimental medicine and biology

2013 Pilot / Observational Human H₂ therapy Drinking (HRW)

2013 · Song et al. — Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome.

Journal of lipid research

2010 Pilot / Observational Human H₂ therapy Drinking (HRW)

2010 · Nakao — Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome - an open label pilot study

Journal of Clinical Biochemistry and Nutrition

2010 Pilot / Observational Human H₂ therapy Inhalation

2010 · Nakayama et al. — A Novel Bioactive Haemodialysis System Using Dissolved Dihydrogen (H₂) Produced by Water Electrolysis: A Clinical Trial

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2006 Pilot / Observational Human H₂ therapy Unspecified

2006 · Huang et al. — Electrolyzed-Reduced Water Reduced Hemodialysis-Induced Erythrocyte Impairment in End-Stage Renal Disease Patients

Kidney international

2003 Pilot / Observational Human H₂ therapy Drinking (HRW)

2003 · Huang — Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water.

Kidney international

1988 Pilot / Observational

1988 · Neale — Dietary Fibre and Health: The Role of Hydrogen Production

Medical hypotheses

2026 Mechanism / Preclinical Inhalation

2026 · Wang — Hydrogen gas inhalation alleviated cerebral ischemia/reperfusion injury by regulating mitophagy in SH-SY5Y cells and mice via PTEN-induced kinase 1/Parkin pathway.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

2026 Mechanism / Preclinical Unspecified

2026 · Zhu — Self-Adaptive Hydrogen Nano-Delivery System in Glaucoma Management: Synergistic Antioxidation and Anti-inflammation Therapeutic Strategy

ACS nano

2026 Mechanism / Preclinical Unspecified

2026 · Němec — The Far Side of Carboranes: Anticancer Active Monocations and Ambiently Stable Dications

Angewandte Chemie (International ed. in English)

2026 Mechanism / Preclinical Inhalation

2026 · Kiyoi — Transcriptome-Based Evaluation of Hydrogen Gas Effects for Preventing UVA-Induced Photoaging Using an Artificial Skin Model

Geriatrics & gerontology international

2026 Mechanism / Preclinical Inhalation

2026 · Li — MXene-Engineered MgB₂ Nanoprodrugs with Acid-Responsive Hydrogen Evolution for Cooperative Photothermal Cancer Ablation

ACS applied materials & interfaces

2026 Mechanism / Preclinical Unspecified

2026 · Zhang — Sub-nano Molybdenum Oxide Nanorings as Amplified Atomic Efficiency Sonosensitizers for Highly Efficient Sonodynamic Tumor Ablation

Nanoscale

2026 Mechanism / Preclinical Inhalation

2026 · Liang — Synergistic Calcium Overload and Hydrogen Release Potentiate Robust Antitumor Immunity

Advanced healthcare materials

2026 Mechanism / Preclinical Drinking (HRW)

2026 · Wu — Hydrogen Ameliorates Psoriasis-Like Skin Inflammation via Inhibiting the cGAS-STING Pathway

Clinical and experimental immunology

2026 Mechanism / Preclinical Inhalation

2026 · Zhang — Pearl-Like Bioinspired Coating Enables Regulation of Mg Degradation for Osteoporotic Bone Repair

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2026 Mechanism / Preclinical Unspecified

2026 · Jiao — Therapeutic Potential of Magnesium Diboride Nanosheets in PAH-Associated Right Heart Failure: Integrated Multi-Omics Analysis Reveals Ferroptosis Suppression via LC3/ATG5/NCOA4/FTH1 Pathway

Free radical biology & medicine

2026 Mechanism / Preclinical Inhalation Drinking (HRW)

2026 · Qin — Tumor Microenvironment-Responsive Hydrogen-Generating Zn-Doped ReZIF-8 Nanoplatform for Enhanced Tumor Suppression

Advanced healthcare materials

2025 Mechanism / Preclinical Unspecified

2025 · Chu — Hydrogen Enhanced Photothermal Therapy for Redox-regulated Tumor Apoptosis and Immune Reprogramming

Acta biomaterialia

2025 Mechanism / Preclinical Bath / Topical

2025 · Zhu — Transdermal Hydrogen Therapy for Psoriasis Using Cavity-embedded Double-conical Microneedles

Journal of controlled release : official journal of the Controlled Release Society

2025 Mechanism / Preclinical Inhalation

2025 · Wang — Spontaneous Hydrogen-releasing Nanoenzyme Alleviates Osteoarthritis via Oxidative Stress Reduction and Mitochondrial Dysfunction Reversal

Journal of nanobiotechnology

2025 Mechanism / Preclinical Drinking (HRW)

2025 · Seya — Hydrogen-rich Gas Enhances Mitochondrial Membrane Potential and Respiratory Function Recovery in Caco-2 Cells Post-ischemia-reperfusion Injury

Biochemical and biophysical research communications

2025 Mechanism / Preclinical Inhalation

2025 · Wang — Hierarchical ROS-scavenging platform breaks vicious cycle of stem cell senescence, angiogenesis arrest, and immune dysregulation in diabetic wounds.

Journal of controlled release : official journal of the Controlled Release Society

2025 Mechanism / Preclinical Drinking (HRW)

2025 · Cao — Nanobiocatalyst-Driven Spatiotemporal Hydrogen Delivery Induces Dormancy Potentiated Catalytic Tumor Therapy.

ACS nano

2025 Mechanism / Preclinical Inhalation

2025 · Lu — Pyroptosis-responsive microspheres modulate the inflammatory microenvironment to retard osteoporosis in female mice.

Nature communications

2025 Mechanism / Preclinical Inhalation

2025 · Zhang — Hydrogen attenuates the senescence of adipose-derived stem cells and enhances their myogenic differentiation via modulation of the PRDX6/SIRT1/PGC-1α signaling pathway.

Human & experimental toxicology

2025 Mechanism / Preclinical Unspecified

2025 · Li — Hydrogen promoted mitochondrial autophagy and alleviated CIH-induced vascular endothelial cell senescence by regulating oxidative stress.

European journal of pharmacology

2025 Mechanism / Preclinical Drinking (HRW)

2025 · Qiu — 3D printing combined with pH-induced 4D printed iron(III)-oxidized starch gels for controlled iron delivery and enhanced iron supplementation.

Carbohydrate polymers

2025 Mechanism / Preclinical Inhalation

2025 · Zhang — RNA-Seq Reveals the Mechanism of Synergistic Hydrogen-Chemotherapy Based on Active Magnesium Micromotors for Inhibiting Glioblastoma Recurrence by Modulating Tumor Microenvironment.

Small (Weinheim an der Bergstrasse, Germany)

2025 Mechanism / Preclinical Inhalation

2025 · Lu — Dietary addition of magnesium hydride nanoparticles: a breakthrough in combating high-fat diet-induced chronic kidney disease.

Medical gas research

2025 Mechanism / Preclinical Inhalation

2025 · Lin — Galvanic Cell Bipolar Microneedle Patches for Reversing Photoaging Wrinkles.

Advanced materials (Deerfield Beach, Fla.)

2025 Mechanism / Preclinical Inhalation

2025 · Mancebo — Performance of Unmodified Mechanical Ventilators With 2% Hydrogen Gas Mixtures.

Respiratory care

2025 Mechanism / Preclinical Unspecified

2025 · Zhang — Ternary Schottky Junction for Sonocatalytic Water Splitting in Gas-Immunotherapy-Mediated Cancer Treatment.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2025 Mechanism / Preclinical Unspecified

2025 · Chen — A Sustained H₂/Fluorouracil-Releasing Suppository for High-efficacy and Low-Toxicity Hydrogenochemotherapy of Colon Cancer.

Advanced healthcare materials

2025 Mechanism / Preclinical Unspecified

2025 · Yu — Protective Effects of Hydrogen Treatment Against High Glucose-Induced Oxidative Stress and Apoptosis via Inhibition of the AGEs/RAGE/NF-κB Signaling Pathway in Skin Cells.

Endocrine, metabolic & immune disorders drug targets

2025 Mechanism / Preclinical Unspecified

2025 · Su — Multifaceted Immunomodulatory Nanocomplexes Target Neutrophilic-ROS Inflammation in Acute Lung Injury.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2025 Mechanism / Preclinical Inhalation

2025 · Ji — Hydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis.

Advanced materials (Deerfield Beach, Fla.)

2025 Mechanism / Preclinical Inhalation

2025 · Hu — Hydrogen-Generating Magnesium Alloy Seed Strand Sensitizes Solid Tumors to Iodine-125 Brachytherapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2025 Mechanism / Preclinical Unspecified

2025 · Jiang — Engineering probiotic biohydrogen micro-factories to initiate reductive stress for boosting tumor vulnerability.

Biomaterials

2025 Mechanism / Preclinical Inhalation

2025 · Ji — Mitochondrial 'Birth-Death' Coordinator: An Intelligent Hydrogen Nanogenerator to Enhance Intervertebral Disc Regeneration

Biomaterials

2025 Mechanism / Preclinical Saline / IV

2025 · Wang — Effect of hydrogen-rich saline on melanopsin after acute blue light-induced retinal damage in rats

Photochemistry and Photobiology

2025 Mechanism / Preclinical Drinking (HRW)

2025 · An — Hydrogen activates ACOD1-itaconate pathway to ameliorate steroid-associated osteonecrosis

Biomaterials

2025 Mechanism / Preclinical Inhalation

2025 · Tian — Molecular hydrogen attenuates cisplatin-induced nephrotoxicity by modulating β-hydroxybutyrate metabolism

Molecular Biology Reports

2024 Mechanism / Preclinical Unspecified

2024 · Li — Modulating the Electronic Structure of MnNi₂S₃ Nanoelectrodes to Activate Pyroptosis for Electrocatalytic Hydrogen-Immunotherapy.

Advanced materials (Deerfield Beach, Fla.)

2024 Mechanism / Preclinical Inhalation

2024 · Tumurbaatar — The effect of hydrogen gas on the oxidative stress response in adipose tissue.

Scientific reports

2024 Mechanism / Preclinical Drinking (HRW)

2024 · Li — Hydrogen-rich water alleviates asthma airway inflammation by modulating tryptophan metabolism and activating aryl hydrocarbon receptor via gut microbiota regulation.

Free radical biology & medicine

2024 Mechanism / Preclinical Unspecified

2024 · Xu — Poly(ionic liquid)-Flocculated Chlorella Loading Bactericidal and Antioxidant Hydrogel as a Biological Hydrogen Therapy for Diabetic Wound Dressing.

ACS applied materials & interfaces

2024 Mechanism / Preclinical Unspecified

2024 · Lin — Hydrogen-treated CoCrMo alloy: a novel approach to enhance biocompatibility and mitigate inflammation in orthopedic implants.

Journal of materials chemistry. B

2024 Mechanism / Preclinical Saline / IV Drinking (HRW)

2024 · Chen — Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway.

World journal of gastroenterology

2024 Mechanism / Preclinical Unspecified

2024 · Meng — Hydrogen Therapy Reverses Cancer-Associated Fibroblasts Phenotypes and Remodels Stromal Microenvironment to Stimulate Systematic Anti-Tumor Immunity.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2024 Mechanism / Preclinical Drinking (HRW)

2024 · Wang — Combined use of hydrogen-rich water and enzyme-digested edible bird's nest improves PMA/LPS-impaired wound healing in human inflammatory gingival tissue equivalents.

Human cell

2024 Mechanism / Preclinical Inhalation

2024 · Chen et al. — Endogenous Melanin and Hydrogen-Based Specific Activated Theranostics Nanoagents: A Novel Multi-Treatment Paradigm for Rheumatoid Arthritis

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2024 Mechanism / Preclinical Drinking (HRW)

2024 · Lu et al. — Decoupling the Mutual Promotion of Inflammation and Oxidative Stress Mitigates Cognitive Decline and Depression-Like Behavior in rmTBI Mice by Promoting Myelin Renewal and Neuronal Survival

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024 Mechanism / Preclinical Inhalation

2024 · Cui — High-concentration hydrogen inhalation mitigates sepsis-associated encephalopathy in mice by improving mitochondrial dynamics

CNS Neuroscience & Therapeutics

2024 Mechanism / Preclinical Inhalation

2024 · Wang — Natural hydrogen gas and engineered microalgae prevent acute lung injury in sepsis

Materials Today Bio

2023 Mechanism / Preclinical Drinking (HRW)

2023 · Makav — The effect of hydrogen-rich water on letrozole-induced polycystic ovary syndrome in rats

Reproductive biomedicine online

2023 Mechanism / Preclinical Inhalation Saline / IV

2023 · Aokage — Attenuation of pulmonary damage in aged lipopolysaccharide-induced inflammation mice through continuous 2 % hydrogen gas inhalation: A potential therapeutic strategy for geriatric inflammation and survival

Experimental gerontology

2023 Mechanism / Preclinical Saline / IV

2023 · Dumbuya — Hydrogen-rich saline regulates NLRP3 inflammasome activation in sepsis-associated encephalopathy rat model

International immunopharmacology

2023 Mechanism / Preclinical Inhalation

2023 · Liu — Hydrogen gas ameliorates acute alcoholic liver injury via anti-inflammatory and antioxidant effects and regulation of intestinal microbiota

International immunopharmacology

2023 Mechanism / Preclinical Inhalation

2023 · Kiyoi — Intermittent environmental exposure to hydrogen prevents skin photoaging through reduction of oxidative stress

Geriatrics & gerontology international

2023 Mechanism / Preclinical Unspecified

2023 · Wang — pH-Responsive Delivery of H₂ through Ammonia Borane-Loaded Hollow Polydopamine for Intervertebral Disc Degeneration Therapy

Oxidative medicine and cellular longevity

2023 Mechanism / Preclinical Unspecified

2023 · Antonenko — Biological Activity of Novel Organotin Compounds with a Schiff Base Containing an Antioxidant Fragment

International journal of molecular sciences

2023 Mechanism / Preclinical Inhalation

2023 · Iketani — H₂-induced transient upregulation of phospholipids with suppression of energy metabolism

Medical gas research

2023 Mechanism / Preclinical Unspecified

2023 · Zhu — Two-Dimensional Mg₂Si Nanosheet-Enabled Sustained Hydrogen Generation for Improved Repair and Regeneration of Deeply Burned Skin

Advanced healthcare materials

2023 Mechanism / Preclinical Saline / IV

2023 · Guo — Hydrogen suppresses oxidative stress by inhibiting the p38 MAPK signaling pathway in preeclampsia

Advances in clinical and experimental medicine : official organ Wroclaw Medical University

2023 Mechanism / Preclinical Unspecified

2023 · Yang — Molecular Hydrogen Promotes Adipose-derived Stem Cell Myogenic Differentiation via Regulation of Mitochondria

Current stem cell research & therapy

2023 Mechanism / Preclinical Inhalation

2023 · Videhult Pierre — Hydrogen Gas Inhalation Attenuates Acute Impulse Noise Trauma: A Preclinical In Vivo Study

The Annals of otology, rhinology, and laryngology

2022 Mechanism / Preclinical Unspecified

2022 · Yan et al. — Microbial Hydrogen „Manufactory” for Enhanced Gas Therapy and Self-Activated Immunotherapy via Reduced Immune Escape

Journal of nanobiotechnology

2022 Mechanism / Preclinical Unspecified

2022 · Yang — Magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer growth

Nature communications

2022 Mechanism / Preclinical Saline / IV

2022 · Li — Local Treatment of Hydrogen-Rich Saline Promotes Wound Healing In Vivo by Inhibiting Oxidative Stress via Nrf-2/HO-1 Pathway

Oxidative medicine and cellular longevity

2022 Mechanism / Preclinical Inhalation Drinking (HRW)

2022 · Adzavon — Long-term and daily use of molecular hydrogen induces reprogramming of liver metabolism in rats by modulating NADP/NADPH redox pathways

Scientific reports

2022 Mechanism / Preclinical Drinking (HRW)

2022 · Mouzakis — Quantification of dissolved H₂ and continuous monitoring of hydrogen-rich water for haemodialysis applications: An experimental study

The International journal of artificial organs

2022 Mechanism / Preclinical Inhalation Saline / IV

2022 · Ge — Microbial hydrogen economy alleviates colitis by reprogramming colonocyte metabolism and reinforcing intestinal barrier

Gut microbes

2022 Mechanism / Preclinical Inhalation Drinking (HRW)

2022 · An — Gender-based differences in neuroprotective effects of hydrogen gas against intracerebral hemorrhage-induced depression

Neurochemistry international

2022 Mechanism / Preclinical Unspecified

2022 · Saitoh — Molecular hydrogen suppresses Porphyromonas gingivalis lipopolysaccharide-induced increases in interleukin-1 alpha and interleukin-6 secretion in human gingival cells.

Molecular and cellular biochemistry

2022 Mechanism / Preclinical Drinking (HRW)

2022 · Mizutani — Hydrogen-rich water reduced oxidative stress and renal fibrosis in rats with unilateral ureteral obstruction.

Pediatric research

2021 Mechanism / Preclinical Unspecified

2021 · Marzullo et al. — Ammonium Formate-Pd/C as a New Reducing System for 1,2,4-Oxadiazoles: Synthesis of Guanidine Derivatives and Reductive Rearrangement to Quinazolin-4-Ones with Potential Anti-Diabetic Activity

International journal of molecular sciences

2021 Mechanism / Preclinical Inhalation Drinking (HRW)

2021 · Yin et al. — Hydrogen Gas with Extracorporeal Cardiopulmonary Resuscitation Improves Survival after Prolonged Cardiac Arrest in Rats

Journal of translational medicine

2021 Mechanism / Preclinical Drinking (HRW)

2021 · LeBaron et al. — An H₂-Infused, Nitric Oxide-Producing Functional Beverage as a Neuroprotective Agent for TBIs and Concussions

Journal of integrative neuroscience

2021 Mechanism / Preclinical Inhalation

2021 · Chu — Mechanism of hydrogen on cervical cancer suppression revealed by high-throughput RNA sequencing

Oncology reports

2021 Mechanism / Preclinical Inhalation

2021 · Li — Hydrogen Attenuates Endotoxin-Induced Lung Injury by Activating Thioredoxin 1 and Decreasing Tissue Factor Expression

Frontiers in immunology

2021 Mechanism / Preclinical Drinking (HRW)

2021 · Kato — Carcinostatic effects of alkanoyl ascorbate plus platinum nano-colloid and stabilization of the esterolytically resultant ascorbate by hydrogen

Human cell

2021 Mechanism / Preclinical Inhalation

2021 · Gopi — Cobalt-modified 2D porous organic polymer for highly efficient electrocatalytic removal of toxic urea and nitrophenol

Chemosphere

2021 Mechanism / Preclinical Drinking (HRW)

2021 · Li et al. — Hydrogen-rich water attenuates the radiotoxicity induced by tritium exposure in vitro and in vivo

Journal of radiation research

2020 Mechanism / Preclinical Drinking (HRW)

2020 · Kwon — Antioxidant Activity of Hydrogen Water Mask Pack Composed of Gel-Type Emulsion and Hydrogen Generation Powder

International journal of molecular sciences

2020 Mechanism / Preclinical Inhalation

2020 · Sun — Photoactivated H₂ Nanogenerator for Enhanced Chemotherapy of Bladder Cancer

ACS nano

2020 Mechanism / Preclinical Drinking (HRW)

2020 · Li — Hydrogen Water Alleviates Paraquat-induced Lung Fibroblast Injury In Vitro by Enhancing Nrf2 Expression

Nan fang yi ke da xue xue bao = Journal of Southern Medical University

2020 Mechanism / Preclinical Inhalation Drinking (HRW)

2020 · Kiyoi — Constitutive Hydrogen Inhalation Prevents Vascular Remodeling via Reduction of Oxidative Stress

PloS one

2020 Mechanism / Preclinical Saline / IV

2020 · Lu — Molecular hydrogen regulates PTEN-AKT-mTOR signaling via ROS to alleviate peritoneal dialysis-related peritoneal fibrosis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2020 Mechanism / Preclinical Unspecified

2020 · Ishihara — Molecular hydrogen suppresses superoxide generation in the mitochondrial complex I and reduced mitochondrial membrane potential.

Biochemical and biophysical research communications

2020 Mechanism / Preclinical Saline / IV Drinking (HRW)

2020 · Jiao — Protective effects of hydrogen-rich saline against experimental diabetic peripheral neuropathy via activation of the mitochondrial ATP-sensitive potassium channel in rats.

Molecular medicine reports

2019 Mechanism / Preclinical Drinking (HRW)

2019 · Li et al. — Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury.

Journal of bioenergetics and biomembranes

2019 Mechanism / Preclinical Inhalation

2019 · Zhang — Hydrogen Gas Improves Photothermal Therapy of Tumor and Restrains the Relapse of Distant Dormant Tumor

Biomaterials

2019 Mechanism / Preclinical Unspecified

2019 · Iuchi — Molecular Hydrogen Suppresses Free-Radical-Induced Cell Death by Mitigating Fatty Acid Peroxidation and Mitochondrial Dysfunction

Canadian journal of physiology and pharmacology

2019 Mechanism / Preclinical Unspecified

2019 · Kröninger — Energy Conservation in the Gut Microbe Methanomassiliicoccus luminyensis Is Based on Membrane-Bound Ferredoxin Oxidation Coupled to Heterodisulfide Reduction

The FEBS journal

2019 Mechanism / Preclinical Drinking (HRW)

2019 · Yamasaki — Effects of hydrogen-rich water in a rat model of polycystic kidney disease.

PloS one

2019 Mechanism / Preclinical Inhalation Saline / IV

2019 · Yan — Hydrogen gas inhalation attenuates sepsis-induced liver injury in a FUNDC1-dependent manner.

International immunopharmacology

2019 Mechanism / Preclinical Unspecified

2019 · Htun — Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model.

Scientific reports

2019 Mechanism / Preclinical Bath / Topical

2019 · Meng — Hyperoxygenated Hydrogen-Rich Solution Suppresses Lung Injury Induced by Hemorrhagic Shock in Rats.

The Journal of surgical research

2019 Mechanism / Preclinical Inhalation

2019 · Yu — Hydrogen gas reduces HMGB1 release in lung tissues of septic mice in an Nrf2/HO-1-dependent pathway.

International immunopharmacology

2019 Mechanism / Preclinical Inhalation

2019 · Guan — Hydrogen gas reduces chronic intermittent hypoxia-induced hypertension by inhibiting sympathetic nerve activity and increasing vasodilator responses via antioxidation.

Journal of cellular biochemistry

2018 Mechanism / Preclinical Unspecified

2018 · Begum — Molecular hydrogen may enhance the production of testosterone hormone in male infertility through hormone signal modulation and redox balance

Medical hypotheses

2018 Mechanism / Preclinical Inhalation

2018 · Dong — Protective effects of hydrogen gas against sepsis-induced acute lung injury via regulation of mitochondrial function and dynamics

International immunopharmacology

2018 Mechanism / Preclinical Unspecified

2018 · Tamaki — Hydrogen Flush After Cold Storage as a New End-Ischemic Ex Vivo Treatment for Liver Grafts Against Ischemia/Reperfusion Injury

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

2018 Mechanism / Preclinical Drinking (HRW)